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1. Brønden LB, Nielsen SS, Toft N, Kristensen AT: Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark. Vet Rec; 2010 May 8;166(19):586-90
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  • [Title] Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark.
  • From May 15, 2005 to April 15, 2008, 1878 cases of neoplasms in dogs were reported to the web-based Danish Veterinary Cancer Registry.
  • The proportions of malignant (38 per cent) and benign (45 per cent) tumours were similar.
  • The most common malignant neoplasms were adenocarcinomas (21 per cent), mast cell tumours (19 per cent) and lymphomas (17 per cent).
  • The benign neoplasms most commonly encountered were lipomas (24 per cent), adenomas (22 per cent) and histiocytomas (14 per cent).
  • Skin (43 per cent) and the female reproductive system including mammary tissue (28 per cent) were the most common locations of neoplasia.
  • There was a distinct breed predisposition for tumour development, with a high standard morbidity ratio (indicating a higher risk of cancer) for boxers and Bernese mountain dogs.
  • [MeSH-major] Dog Diseases / epidemiology. Neoplasms / veterinary. Pedigree. Registries / statistics & numerical data

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  • (PMID = 20453236.001).
  • [ISSN] 2042-7670
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Onder M, Adişen E: A new indication of botulinum toxin: leiomyoma-related pain. J Am Acad Dermatol; 2009 Feb;60(2):325-8
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  • Cutaneous leiomyomas are benign neoplasms with smooth muscle differentiation.
  • They are painful tumors of the skin.
  • Botulinum toxin has no known systemic adverse effects, and can be combined with other treatments without concern for drug interactions.
  • Like any other medication, aside from its actual pharmacologic effect, botulinum toxin may have had a placebo effect in our patient.
  • [MeSH-major] Botulinum Toxins / therapeutic use. Leiomyomatosis / complications. Pain / drug therapy. Pain / etiology. Skin Neoplasms / complications

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  • (PMID = 19150277.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; EC 3.4.24.69 / Botulinum Toxins
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3. Akhter J, Hirachand S, Lakhey M: Role of FNAC in the diagnosis of salivary gland swellings. Kathmandu Univ Med J (KUMJ); 2008 Apr-Jun;6(2):204-8
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  • [Title] Role of FNAC in the diagnosis of salivary gland swellings.
  • RESULTS: In this series of FNAC, 16 cases (40%) were benign neoplasms, 5 cases (12.5%) malignant neoplasms, non-neoplastic cysts 3 cases (7.5%) and inflammatory lesions 16 cases (40%).Histopathology was available in 24 cases out of which 22 cases correlated with cytology.
  • CONCLUSION: FNAC is useful in the diagnosis of salivary gland swellings especially in benign conditions with a sensitivity of 90% and specificity of 100%.
  • [MeSH-major] Biopsy, Fine-Needle. Cysts / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Sialadenitis / diagnosis

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  • (PMID = 18769087.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Nepal
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4. Lott S, Lopez-Beltran A, Maclennan GT, Montironi R, Cheng L: Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential. Hum Pathol; 2007 Jun;38(6):807-23
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  • [Title] Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential.
  • Most bladder tumors arise from the urothelium.
  • These include both benign and malignant spindle cell lesions.
  • The first half of this 2-part review will describe benign myofibroblastic proliferations including inflammatory myofibroblastic tumor and postoperative spindle cell nodule; benign neoplasms including leiomyoma, hemangioma, neurofibroma, and schwannoma; and tumors of uncertain malignant potential including paraganglioma, granular cell tumor, and perivascular epithelioid cell tumor.
  • This review also describes current theories as to the pathogenesis of inflammatory myofibroblastic tumor and postoperative spindle cell nodule and details the current molecular markers identifying several of these lesions.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 17509394.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 87
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5. Adams PD, Enders GH: Wnt-signaling and senescence: A tug of war in early neoplasia? Cancer Biol Ther; 2008 Nov;7(11):1706-11
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  • [Title] Wnt-signaling and senescence: A tug of war in early neoplasia?
  • Studies of early neoplasia have revealed fundamental molecular pathways that drive tumorigenesis.
  • We envision commonality of pathways important in formation of two early benign neoplasms that are found in different tissues and which are not generally thought to be similar: dysplastic nevi of the skin and intestinal aberrant crypt foci.
  • We propose that these neoplasms result from an ongoing 'tug of war' between the tumor suppression barrier posed by cellular senescence and the tumor-promoting activity of Wnt-signaling.
  • Whether or not such neoplasms progress to malignancy or persist in a benign state for many years might be largely determined by the outcome of this tug of war and its modulation by other genetic and epigenetic alterations, such as inactivation of p16(INK4a).

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  • (PMID = 18836285.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK64758; United States / NIGMS NIH HHS / GM / R01 GM062281; United States / NIGMS NIH HHS / GM / GM062281-08; United States / NCI NIH HHS / CA / R01CA129334-01; United States / NCI NIH HHS / CA / R01 CA129334-01A1; United States / NCI NIH HHS / CA / CA129334-01A1; United States / NIA NIH HHS / AG / AG031862-010002; United States / NIA NIH HHS / AG / P01 AG031862; United States / NCI NIH HHS / CA / R01 CA129334; United States / NIDDK NIH HHS / DK / R01 DK064758; United States / NIDDK NIH HHS / DK / DK064758-06; United States / NIDDK NIH HHS / DK / R01 DK064758-06; United States / NIA NIH HHS / AG / P01 AG031862-010002; United States / NIGMS NIH HHS / GM / R01 GM062281-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Other-IDs] NLM/ NIHMS80646; NLM/ PMC2783518
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6. Fine SW, Chan TY, Epstein JI: Inverted papillomas of the prostatic urethra. Am J Surg Pathol; 2006 Aug;30(8):975-9
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  • Inverted papillomas of the genitourinary tract are uncommon benign neoplasms usually occurring in the urinary bladder and less frequently in the upper urinary tract.
  • Patients had a mean age of 65.1 years (range: 30 to 89 y), with 10/21 (47.6%) presenting with gross hematuria (n = 8) or irritative symptoms (n = 2) related to the inverted papilloma and 11/21 (52.4%) detected incidentally during work-up/treatment of prostate cancer (n = 6) or benign prostatic hypertrophy (BPH) (n = 5).
  • The remaining cases showed foci of squamous metaplasia with moderate atypia (n = 4), rare true papillary fronds in a classic inverted papilloma background (n = 2), or both (n = 1).
  • Eleven cases with prostatic tissue revealed adenocarcinoma of the prostate [n = 6; Gleason score 6 (n = 3) or 7 (n = 3)], high-grade prostatic intraepithelial neoplasia (n = 1), benign prostatic hypertrophy (n = 3), or adenosis (n = 1).
  • No patients had a prior history of either inverted papilloma or urothelial carcinoma, whereas 2 patients were diagnosed with high-grade urothelial carcinoma of the bladder synchronous with their inverted papilloma diagnosis.
  • None of the other patients had local recurrences or recurrences at other locations in the urinary tract (mean follow-up 39.9 mo; range: 3 to 120 mo).
  • Inverted papillomas of the prostatic urethra are benign lesions that are commonly detected incidentally and are not associated with a history of urothelial malignancy.
  • Although urothelial carcinoma elsewhere in the genitourinary tract may occur simultaneously, malignant transformation or recurrence as a malignant lesion has not been identified in inverted papilloma of the prostatic urethra.
  • [MeSH-major] Papilloma, Inverted / pathology. Prostate / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Humans. Incidental Findings. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Prognosis. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16861968.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Awadalla F, Rosenbaum DA, Camacho F, Fleischer AB Jr, Feldman SR: Dermatologic disease in family medicine. Fam Med; 2008 Jul-Aug;40(7):507-11
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  • The five most common skin disorders diagnosed by family physicians were dermatitis, pyoderma, tinea, benign neoplasms, and candida.
  • [MeSH-major] Family Practice / statistics & numerical data. Skin Diseases / diagnosis

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  • (PMID = 18928078.001).
  • [ISSN] 0742-3225
  • [Journal-full-title] Family medicine
  • [ISO-abbreviation] Fam Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Glucocorticoids; 0 / Histamine H1 Antagonists; 0 / Sunscreening Agents
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8. Kamate B, Traore CB, Diallo D, Foko I, Sangare F, Malle B, Coulibaly B, Mounkoro N, Bayo S: [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases]. Mali Med; 2008;23(3):36-9
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  • [Title] [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases].
  • [Transliterated title] Epidemiologie et morphologie des tumeurs benignes du sein au Mali: a propos de 186 cas.
  • BACKGROUND: Mammary tumors are frequent.
  • Benign tumors are more frequent, and are characterized by a possibility of recurrence or malignant transformation.
  • The aim of this study was to describe the epidemiological and morphological characteristics of breast benign tumors.
  • The study had concerned all benign tumors confirmed by histology.
  • FINDINGS: In total, 186 benign tumors were diagnosed over 611 mammary pathologies (30.44%).
  • Tumor sizes were variable, and the color changed through white to yellow.
  • Histological aspects were: fibroadenoma (72%), lipoma (8.6%), tubular adenoma (5.9%), papilloma (5.4%), lactating adenoma (3.8%), phyllodes tumor (3.8%), and syringomatous tumor (0.5%).
  • CONCLUSION: Benign tumors are frequent in mammary pathology.
  • The patients need a follow-up because of the recurrence or the malignant transformation of these tumors.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / pathology

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  • (PMID = 19617151.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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9. Lortscher DN, Sengelmann RD, Allen SB: Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome. Dermatol Online J; 2007;13(2):21
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  • Basal cell nevus syndrome is an autosomal dominant disorder characterized by multiple basal cell carcinomas, along with numerous other documented clinical features.
  • Acrochordons (or skin tags) are common benign neoplasms that are appropriately left untreated in most patients.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Risk Assessment

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  • (PMID = 17498440.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • Lipomas are common benign neoplasms of adipose tissue.
  • This case occurred in a 77-year-old woman who developed multiple lipomas two years after beginning treatment with pioglitazone, a PPAR gamma agonist.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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11. Figueroa-Torres Y, Martínez-Ojeda JA, Franqui-Rivera H, Martínez-Toro J: Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean. P R Health Sci J; 2008 Dec;27(4):373-6
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  • [Title] Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean.
  • INTRODUCTION: Neoplasms of the heart are extremely rare and difficult to diagnose.
  • In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms.
  • A total of 77 cases with a diagnosis of Benign Heart Neoplasm were found from 1992 to 2008 but only those with an official pathologic report (n = 43) were considered.
  • The clinical charts provided data related to age, sex, presenting symptoms, non-invasive and invasive characteristics, surgical procedures, and pathological findings.
  • RESULTS: The mean age for diagnosis was 51.49 years.
  • The most common location of the mass was the left atrium (81%) and overall, the most common heart neoplasm in this study was myxoma (83.7%).
  • CONCLUSIONS: This study of a total of 43 pathologically confirmed benign cardiac neoplasms admitted to the Cardiovascular Center of Puerto Rico and the Caribbean from 1992 to 2008 validates the fact that heart neoplasms represent a fairly rare diagnosis.
  • It is also consistent with previously published series that establish myxoma as the most common of these benign neoplasms.
  • [MeSH-major] Heart Neoplasms / diagnosis

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  • (PMID = 19069370.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
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12. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9
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  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology
  • [MeSH-minor] Adenocarcinoma / genetics. Breast Neoplasms / genetics. Endometrial Neoplasms / genetics. Female. Goiter, Nodular / genetics. Humans. Lymphangioma / etiology. Mastectomy. Middle Aged. Postoperative Complications / etiology

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  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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13. Havu-Aurén K, Kiiski J, Lehtiö K, Eskola O, Kulvik M, Vuorinen V, Oikonen V, Vähätalo J, Jääskeläinen J, Minn H: Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. Eur J Nucl Med Mol Imaging; 2007 Jan;34(1):87-94
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  • Boron neutron capture therapy (BNCT) is a chemically targeted form of radiotherapy requiring increased concentration of boron-10 in tumour tissue.
  • [(18)F]FBPA uptake in tumour and brain was assessed with a three-compartmental model and graphical analysis.
  • These, together with standardised uptake values (SUVs), were used to define tumour-to-brain [(18)F]FBPA tissue activity gradients.
  • RESULTS: Model fits with three parameters K (1) (transport), k (2) (reverse transport) and k (3) (intracellular metabolism) were found to best illustrate [(18)F]FBPA uptake kinetics.
  • Maximum SUV was two- to fourfold higher in tumour as compared with normal brain and independent of NF2 status.
  • The increased uptake was due to higher transport of [(18)F]FBPA in tumour.
  • In multiple-time graphical analysis (MTGA, Gjedde-Patlak plot) the tumour-to-brain [(18)F]FBPA influx constant (K (i) -MTGA) ratios varied between 1.8 and 5.4 in NF2-associated tumours while in sporadic tumours the ratio was 1-1.4.
  • Based on our results on tumour uptake of [(18)F]FBPA, some of these benign neoplasms may be amenable to BNCT.
  • [MeSH-major] Boron Compounds / pharmacokinetics. Brain Neoplasms / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Neurilemmoma / metabolism. Neurofibromatoses / metabolism. Phenylalanine / analogs & derivatives

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  • (PMID = 16896669.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiopharmaceuticals; 133921-60-5 / 4-borono-2-fluorophenylalanine; 47E5O17Y3R / Phenylalanine
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14. Maes L, Lippens E, Kalala JP, de Ridder L: The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas. Cell Prolif; 2005 Feb;38(1):3-12
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  • [Title] The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas.
  • Meningiomas are considered as benign neoplasms affecting the coverings of the central nervous system and compromise approximately 20% of all intracranial tumours.
  • The interdependence between tumour recurrence and cell proliferation in this study is analysed by Ki-67 immunoreactivity (clone MIB-1).
  • Archival material from 29 non-recurrent and 32 recurrent tumours has been evaluated, including specimens from World Health Organization (WHO) stages I (n = 73), II (n = 2) and III (n = 12).
  • Although the tumours were categorized as benign meningiomas following the WHO classification, recurrence in 22 of 50 cases did not correlate with the tumour stage.
  • For hTERT staining, the following results were found for nucleolar and total nuclear staining, respectively: non-recurrent meningiomas, 2.9% (+/- 7.7) and 3.0% (+/- 8.0); recurrent meningiomas at first resection, 16.8% (+/- 19.7) and 31.6% (+/- 30.2).
  • Concerning the Ki-67 labelling index (LI): for the group of non-recurrent meningiomas, results were 2.1% (+/- 1.7) and for the recurrent group at first resection, 1.7% (+/- 2.0).
  • A significant difference was seen for the hTERT staining (P < 0.001) between the non-recurrent and recurrent meningiomas, whereas no statistical significance was found for Ki-67.
  • [MeSH-major] Antigens, Neoplasm. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Telomerase / biosynthesis

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  • (PMID = 15679862.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 2.7.7.49 / Telomerase
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15. Mennigen R, Wolters HH, Schulte B, Pelster FW: Segmental resection of the duodenum for gastrointestinal stromal tumor (GIST). World J Surg Oncol; 2008;6:105
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  • [Title] Segmental resection of the duodenum for gastrointestinal stromal tumor (GIST).
  • BACKGROUND: Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the gastrointestinal tract.
  • The biological appearance of these tumors reaches from small lesions with benign appearance to aggressive sarcomas.
  • CASE PRESENTATION: A 29-year-old man presented with an acute upper gastrointestinal bleeding from a submucosal tumor located in the proximal part III of the duodenum, 3 cm distal of the papilla of Vater.
  • After an emergency laparotomy with ligation of tumor-feeding vessels in a primary hospital, definitive surgical therapy was performed by partial resection of the duodenum with a duodenojejunostomy.
  • CONCLUSION: GISTs of the duodenum are a rare cause of upper gastrointestinal bleeding.
  • [MeSH-major] Duodenal Neoplasms / surgery. Duodenum / surgery. Gastrointestinal Stromal Tumors / surgery

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  • (PMID = 18826622.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2567321
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16. Kianmanesh R, O'toole D, Sauvanet A, Ruszniewski P, Belghiti J: [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors]. J Chir (Paris); 2005 May-Jun;142(3):132-49
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  • [Title] [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors].
  • [Transliterated title] Traitement chirurgical des tumeurs endocrines gastro-entéro-pancréatiques.
  • Endocrine tumors (ET) of the digestive tract (formerly called neuroendocrine tumors) are rare.
  • They are classified into two principal types: gastrointestinal ET's (formerly called carcinoid tumors) which are the most common, and pancreaticoduodenal ET's.
  • Functioning ET's secrete polypeptide hormones which cause characteristic hormonal syndromes.
  • The management of ET is multidisciplinary.
  • Poorly-differentiated ET's have a poor prognosis and are treated by chemotherapy.
  • Surgical excision is the only curative treatment of well-differentiated ET's.
  • The surgical goals are to: 1. prolong survival by resecting the primary tumor and any nodal or hepatic metastases, 2. control the symptoms related to hormonal secretion, 3. prevent or treat local complications.
  • The most common sites of gastrointestinal ET's ( carcinoids) are the appendix and the rectum; these are often small (<1 cm), benign, and discovered fortuitously at the time of appendectomy or colonoscopic removal.
  • Ileal ET's, even if small, are malignant, frequently multiple, and complicated in 30-50% of cases by bowel obstruction, mesenteric invasion, or bleeding.
  • More than half of the cases of pancreatic ET are non-functional.
  • They are usually malignant and of advanced stage at diagnosis presenting as a palpable or obstructing mass or as liver metastases.
  • Insulinoma and gastrinoma (cause of the Zollinger-Ellison syndrome) are the most common functional ET's. 80% are sporadic; in these cases, tumor size, location, and malignant potential determine the type of resection which may vary from a simple enucleation to a formal pancreatectomy.
  • In 10-20% of cases, pancreaticoduodenal ET presents in the setting of multiple endocrine neoplasia (NEM type I), an autosomal-dominant genetic disease with multifocal endocrine involvement of the pituitary, parathyroid, pancreas, and adrenal glands.
  • For gastrinoma with NEM-I, the benefit of surgical resection for tumors less than 2-3 cm in size is not clear.
  • [MeSH-major] Carcinoid Tumor / surgery. Carcinoma, Islet Cell / surgery. Carcinoma, Neuroendocrine / surgery. Insulinoma / surgery. Intestinal Neoplasms / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatic Neoplasms / surgery. Stomach Neoplasms / surgery. Zollinger-Ellison Syndrome / surgery
  • [MeSH-minor] Adult. Gastrinoma / diagnosis. Gastrinoma / surgery. Glucagonoma / diagnosis. Glucagonoma / surgery. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Malignant Carcinoid Syndrome / diagnosis. Malignant Carcinoid Syndrome / surgery. Multicenter Studies as Topic. Pancreatectomy. Postoperative Care. Postoperative Complications. Prognosis. Somatostatinoma / diagnosis. Somatostatinoma / surgery. Vipoma / diagnosis. Vipoma / surgery

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  • (PMID = 16142076.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 236
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17. Ioncica AM, Malos A, Crisan E, Popescu C, Saftoiu A, Ciurea T: State-of-the art endoscopic imaging in lung cancer: should specialties collide or concur? J Gastrointestin Liver Dis; 2010 Mar;19(1):93-7
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  • Transesophageal endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) represents a method which not only allows the visualization of the upper gastrointestinal tract, but also offers good visualisation of the posterior and inferior mediastinum.
  • Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) permits the assessment of the tumors in the anterior mediastinum.
  • Based on previously published literature, it is obvious that this minimally invasive procedure now offers the possibility of tissue diagnosis in mediastinal masses including primary tumours or secondary lesions from both benign and malignant diseases.
  • [MeSH-major] Biopsy, Fine-Needle. Bronchoscopy. Echocardiography, Transesophageal. Endosonography. Lung Neoplasms / diagnosis. Ultrasonography, Interventional
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 20361084.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
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18. Miettinen M, Kraszewska E, Sobin LH, Lasota J: A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer; 2008 Feb 1;112(3):645-9
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  • [Title] A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia.
  • BACKGROUND: Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling.
  • These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant.
  • None of the GIST patients had received radiotherapy or chemotherapy prior to the leukemia diagnosis.
  • All but 1 GIST case was found to have a low mitotic rate (0-1 per 50 high-power fields); however, tumor size varied from 3 to 18 cm (median, 4.5 cm).
  • Standardized incidence ratios (SIRs) and their 95% confidence intervals (95% CIs) were calculated comparing the incidences of AML/CMLs in GIST patients with those in the 2000 through 2003 U.S. population.
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Intestinal Neoplasms / epidemiology. Leukemia, Myeloid / epidemiology. Stomach Neoplasms / epidemiology


19. Vilallonga R, Espin Basany E, Armengol M: Cavernous hemangioma: unusual benign tumor of the transverse colon. Turk J Gastroenterol; 2009 Jun;20(2):146-9
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  • [Title] Cavernous hemangioma: unusual benign tumor of the transverse colon.
  • Cavernous hemangioma of the colon is an uncommon disease and a rare cause of bleeding.
  • The rectosigmoid is the most common site of this disease in the gastrointestinal tract, while colonic localization is very uncommon.
  • We report the case of a 66-year-old female with recurrent episodes of rectal bleeding.
  • This tumor can be diagnosed as solitary, multiple, or part of a more complex syndrome with cutaneous manifestations.
  • Sometimes, however, recognition of these tumors is difficult and can be a cause of failed surgical treatment and severe complications.
  • Surgical treatment is recommended, after a full diagnostic evaluation for other causes of gastrointestinal bleeding.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Hemangioma, Cavernous / diagnosis

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  • (PMID = 19530050.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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20. Han MW, Lee BJ, Jang YJ, Chung YS: Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses. Otolaryngol Head Neck Surg; 2010 Sep;143(3):341-7
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  • [Title] Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses.
  • SUBJECTS AND METHODS: From January 1997 to August 2006, preoperative diagnosis was achieved using endoscopic incisional biopsy in 521 patients.
  • Cytopathologic and histologic findings were categorized as malignancy, benign neoplasm, or non-neoplastic lesion.
  • We investigated the accuracy of endoscopic incisional biopsy and preoperative imaging by comparing it with pathologic results from tumor resection as the "gold standard."
  • RESULTS: Most of the patients had unilateral nasal symptoms (e.g., nasal obstruction, unilateral epistaxis, unilateral facial pain), and the clinical symptoms were of little diagnostic value in the differentiation of tumor and inflammatory lesion.
  • The sensitivity and specificity of endoscopic incisional biopsy were 43.7 and 98.9 percent, respectively, for the diagnosis of nasal cavity malignancies, and 78.2 and 96.2 percent, respectively, for the diagnosis of benign neoplasms.
  • The sensitivity and specificity of preoperative imaging were 78.3 and 97.5 percent, respectively, for the diagnosis of nasal cavity malignancies and 66.4 and 86.3 percent, respectively, for the diagnosis of benign neoplasms.
  • CONCLUSION: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies.
  • [MeSH-major] Ambulatory Surgical Procedures. Biopsy / methods. Endoscopy. Nasal Cavity. Nose Neoplasms / pathology

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20723769.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON; 2008 Oct-Dec;13(4):581-4
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  • [Title] Glomus tumor of the stomach: a case report.
  • Glomus tumors are relatively uncommon benign neoplasms, most common in the skin and subcutaneous tissue, but can also occur in the viscera, most often in the stomach.
  • Preoperative diagnosis, when the tumor occurs in the stomach, seems difficult but is important, since glomus tumors of the stomach are essentially benign and amenable to conservative excision, contrary to aggressive gastric neoplasms.
  • We describe the case of a 75-year-old man presented to the emergency department with gastrointestinal bleeding and epigastric pain.
  • Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
  • Histological examination of the tumor confirmed the diagnosis of gastric glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19145686.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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22. Konstantinidis K, Theodoropoulos GE, Spanomihos G, Sambalis G, Vorias M, Georgiou M, Anastassakou K: Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):396-9
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  • [Title] Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding.
  • A 2.5 cm diameter, smooth, hypervascular tumor was easily visualized on the jejunal wall 10 cm from the ligament of Treitz.
  • The small bowel segment was laparoscopically mobilized and brought through the subumbilical trocar site, which was extended 1 cm.
  • A limited small bowel resection and a stapled anastomosis were easily performed extracorporeally.
  • Histopathologic examination diagnosed a benign gastrointestinal tumor (gastrointestinal stromal tumor, leiomyoma).
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Intestinal Neoplasms / complications. Intestinal Neoplasms / surgery. Leiomyoma / complications. Leiomyoma / surgery

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  • (PMID = 16108744.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Ohta H, Fukushima N, Ozono K: Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation. Int J Hematol; 2009 Sep;90(2):127-36
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  • [Title] Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
  • Post-transplant lymphoproliferative disorder (PTLD) is a well recognized and potentially fatal complication after pediatric cardiac transplantation.
  • PTLD encompasses a wide spectrum, ranging from benign hyperplasia to more aggressive lymphoma.
  • Most cases are Epstein-Barr virus (EBV)-related B-cell tumors resulting from impaired immunity due to immunosuppressive therapy.
  • The clinical presentation of PTLD varies from isolated lymphadenopathy to systemic disease; common sites involved are gastrointestinal tract, lung or airway, and cervical lesions.
  • Timely and accurate diagnosis based on histological examination of biopsy tissue is essential for early intervention.

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  • (PMID = 19669857.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 99
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24. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Intussusception has been considered an operative indication in adults as a result of the risk of ischemia and the possibility of a malignant lead point.
  • Seven had,enteroenteric intussusceptions from benign neoplasms (two), adhesions (one), local inflammation (one), previous anastomosis (one), Crohn's disease (one), and idiopathic (one).
  • Of the 15 without intussusception at exploration, five had pathology related to trauma, four had nonincarcerated internal hernia after Roux-en-Y gastric bypass, four had negative explorations, one had adhesions, and one had appendicitis that did not correlate with CT findings.
  • All operative patients demonstrated gastrointestinal symptoms versus 55.3 per cent of the observation group (P < 0.006).
  • Most cases can be treated expectantly despite the presence of gastrointestinal symptoms.
  • Length and diameter of the intussusception, presence of a lead point, or bowel obstruction on CT are predictive of findings that warrant exploration.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women.
  • CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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26. Puggioni A, Delis KT, Fields CE, Viozzi CF, Kallmes DF, Gloviczki P: Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation. Perspect Vasc Surg Endovasc Ther; 2005 Mar;17(1):21-8
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  • [Title] Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation.
  • Carotid body tumors (CBT) are rare and usually benign neoplasms (60%-90%), originating from the mesoderm and neural ectoderm.
  • Despite progress in CBT imaging and surgical technique, cranial nerve deficit, stroke, and death continue to affect 10% to 40% of patients undergoing curative surgical resection, particularly in large tumors proximal to the skull base.
  • In such cases, CBT shrinkage by preoperative embolization, improved surgical access utilizing mandibular subluxation, and electroencephalographic monitoring combined with meticulous surgical technique may enable curative tumor resection, without prohibitive morbidity.
  • [MeSH-major] Carotid Body Tumor / surgery. Mandible / surgery

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  • (PMID = 15952693.001).
  • [ISSN] 1531-0035
  • [Journal-full-title] Perspectives in vascular surgery and endovascular therapy
  • [ISO-abbreviation] Perspect Vasc Surg Endovasc Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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28. Krysiak R, Okopień B, Marek B, Szkróbka W: [Prolactinoma]. Przegl Lek; 2009;66(4):198-205
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  • Prolactin-secreting tumours (prolactinomas) are benign neoplasms constituting about 40 percent of all pituitary tumours.
  • Differential diagnosis of the disease should include the intake of various drugs, hypothyroidism, renal failure, liver cirrhosis, compression of the pituitary stalk by other pathologies, idiopathic hyperprolactinemia and other types of pituitary adenomas.
  • The aims of treatment are to restore or to achieve eugonadism through the normalisation of hyperprolactinemia and control of tumour mass.
  • The authors review the diagnosis and management of prolactinomas, including progress made in recent years.
  • [MeSH-major] Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy. Prolactinoma / diagnosis. Prolactinoma / therapy
  • [MeSH-minor] Adult. Age Distribution. Causality. Dopamine Agonists / therapeutic use. Female. Humans. Iatrogenic Disease / epidemiology. Male. Pregnancy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / epidemiology. Pregnancy Complications, Neoplastic / therapy. Prevalence. Sex Distribution. Young Adult

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  • (PMID = 19708510.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Dopamine Agonists
  • [Number-of-references] 53
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29. Muşat M, Morris DG, Korbonits M, Grossman AB: Cyclins and their related proteins in pituitary tumourigenesis. Mol Cell Endocrinol; 2010 Sep 15;326(1-2):25-9
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  • Pituitary tumours are benign neoplasms that may cause major endocrine dysfunction.
  • Nevertheless, molecular CDK inhibitors may play a role in pituitary tumour treatment in the future.
  • [MeSH-major] Cyclins / physiology. Pituitary Neoplasms / etiology
  • [MeSH-minor] Cell Cycle Proteins / metabolism. Cyclin E / metabolism. Cyclin E / physiology. Cyclin-Dependent Kinases / antagonists & inhibitors. Cyclin-Dependent Kinases / genetics. Humans. Multiple Endocrine Neoplasia Type 1 / genetics. Neoplasms. Pituitary Gland / metabolism. Pituitary Gland / pathology

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  • [Copyright] 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20347931.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / Cyclins; EC 2.7.11.22 / Cyclin-Dependent Kinases
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30. Baderca F, Cojocaru S, Lazăr E, Lăzureanu C, Faur A, Lighezan R, Alexa A, Raica M, Vălean M, Balica N: Schwannoma of the lip: case report and review of the literature. Rom J Morphol Embryol; 2008;49(3):391-8
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  • Schwannomas of the lip are rare, benign neoplasms which vary in size.
  • The diagnosis is typically made at the time of surgery following biopsy and surgical resection is the mainstay of treatment.
  • We present one case of lip schwannoma: the patient was 25-year-old and he has presented to otorhinolaryngologist for a non-dolorous tumor on the mucosal side of his inferior lip, which was increasing in size for the last six months.
  • The tumor had a superficial ulceration and infection.
  • The tumor was radically removed, and the sections were stained with Hematoxylin-Eosin.
  • The tumor was encapsulated and showed two different pattern of growth.
  • Verocay bodies, which were presented in Antoni A areas, are whorled formations of palisading tumor cells.
  • The cells of neoplasm were monotone.
  • In addition, immunohistochemical labeling was performed for S-100 protein, vimentin, GFAP and NSE and confirmed the diagnosis.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18758646.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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31. Pasieka JL: Carcinoid tumors. Surg Clin North Am; 2009 Oct;89(5):1123-37
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  • [Title] Carcinoid tumors.
  • Carcinoid tumors, which arise from the enterochromaffin cells of the gastrointestinal tract, encompass a diverse group of neoplasms.
  • Once thought to be "carcinoma-like," these neoplasms exhibit a biologic behavior that varies from an indolent, benign course to an aggressive, rapidly progressive, and deadly disease.
  • Today the term carcinoid is reserved for neuroendocrine tumors arising from the small bowel or neuroendocrine tumors that can cause carcinoid syndrome.
  • For the general surgeon there are several "carcinoid" tumors that he or she must be familiar with because many of these lesions are encountered during emergency laparotomies or incidentally discovered during investigation for vague abdominal pain.
  • This review focuses on the gastrointestinal neuroendocrine tumors that general surgeons are likely to encounter during their career.
  • [MeSH-major] Carcinoid Tumor / surgery. Gastrointestinal Neoplasms / surgery. Neuroendocrine Tumors / surgery

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  • (PMID = 19836488.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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32. Pickhardt PJ, Kim DH, Meiners RJ, Wyatt KS, Hanson ME, Barlow DS, Cullen PA, Remtulla RA, Cash BD: Colorectal and extracolonic cancers detected at screening CT colonography in 10,286 asymptomatic adults. Radiology; 2010 Apr;255(1):83-8
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  • Benign neoplasms (including advanced colorectal adenomas), symptomatic lesions, and tumors without pathologic proof were excluded.
  • Extracolonic malignancies included renal cell carcinoma (n = 11), lung cancer (n = 8), non-Hodgkin lymphoma (n = 6), and a variety of other tumors (n = 11).
  • [MeSH-major] Colonography, Computed Tomographic. Colorectal Neoplasms / diagnostic imaging
  • [MeSH-minor] Adenoma / diagnostic imaging. Adenoma / pathology. Female. Humans. Kidney Neoplasms / diagnostic imaging. Kidney Neoplasms / pathology. Lung Neoplasms / diagnostic imaging. Lung Neoplasms / pathology. Lymphatic Metastasis. Lymphoma, Non-Hodgkin / diagnostic imaging. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Multiple Primary / pathology. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • [Copyright] RSNA, 2010
  • (PMID = 20308446.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA144835
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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33. Mohammed F, Asaria J, Payne RJ, Freeman JL: Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):340-6
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  • OBJECTIVE: To compare the trends and specific outcomes of patients treated surgically for parotid neoplasms between 1994 and 2005 with those of patients who were treated between 1985 and 1993 at Mount Sinai Hospital in Toronto and to identify preoperative indicators of malignancy.
  • Of these patients, 183 (75.6%) had benign neoplasms, 51 (21.1%) had malignant neoplasms, and 8 (3.3%) had inflammatory or lymphatic lesions.
  • Comparison of these results with the other study at our institution revealed no significant differences in patient predictors or outcomes.
  • CONCLUSIONS: These results were compared with those of a previous study conducted at the same institution between 1985 and 1993.
  • [MeSH-major] Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Facial Pain / diagnosis. Facial Pain / epidemiology. Facial Pain / etiology. Female. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Staging. Ontario / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Survival Rate / trends. Young Adult

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  • (PMID = 19128637.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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34. Kim HS, Yun KJ: Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology. Diagn Cytopathol; 2008 Apr;36(4):253-6
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  • [Title] Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.
  • Adenolipomas are rare benign neoplasms composed of mature adipose tissue and thyroid follicles.
  • A 65-year-old woman presented with a 4-month history of a thyroid nodule.
  • A FNA cytology specimen showed a few benign follicular cells with adipose tissue.
  • Microscopic findings showed a solid tumor predominantly composed of mature adipose tissue intermixed with thyroid follicles.
  • The pathological diagnosis was adenolipoma of the thyroid gland.
  • [MeSH-major] Lipoma / diagnosis. Thyroid Neoplasms / diagnosis

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335547.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • Peutz Jeghers (PJ) polyps are rare hamartomatous tumors of the gastrointestinal tract frequently associated with skin and mucosal pigmentation.
  • Despite their benign nature there is a certain increased risk of progression to malignancy in some cases, justifying a sustained follow-up of the patients.
  • We present 3 cases of Peutz Jeghers syndrome (PJS) diagnosed in our hospital on gastrointestinal specimens obtained by endoscopy and opened surgery.
  • We analyzed different degrees of dysplastic changes, epithelial intussusception, association with other types of polypoid lesions and other various aspects possibly related with disease progression.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • The other case showed diagnostic changes of PJS and also various aspects of adenomatous polyps some of them with mild and moderate dysplastic changes.
  • When a PJ polyp is diagnosed, the possibility of pseudoinvasion should be kept in mind, in order to avoid overdiagnosis of malignancy; also, due to the fact that the malignant transformation of a PJ polyp is still on debate (hamartoma-dysplasia-carcinoma sequence versus malignant transformation of an adenomatous aria of a hamartoma versus coincidental association of a digestive cancer due to genetic aberrations of PJS), all the other associated microscopic aspects of the lesion should be carefully analyzed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Intestinal Neoplasms / pathology. Intestinal Polyps / pathology. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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36. Parra-Herran CE, Garcia MT, Herrera L, Bejarano PA: Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period. JOP; 2010;11(4):358-64
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  • [Title] Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period.
  • CONTEXT: Cystic lesions of the pancreas represent an important subgroup of pancreatic tumors.
  • SETTING: Cases were subclassified in diagnostic categories and were grouped according to the nature of the lesion (non-neoplastic vs. neoplastic).
  • Among the 97 cysts, five (5.2%) were non-neoplastic and 92 (94.8%) were neoplastic (59.8% benign, 17.5% borderline, 17.5% malignant).
  • Intraductal papillary mucinous neoplasm was the most common diagnosis (n=51; 52.6%) followed by serous cystic neoplasm (n=20; 20.6%) and mucinous cystic neoplasm (n=13; 13.4%).
  • Tumor size was significantly lower in benign neoplastic lesions (P=0.045).
  • Incidental identification was more frequent in benign lesions (P=0.028), whereas malignant lesions were more frequently symptomatic (P=0.001).
  • Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining.
  • Age at presentation, gender, location and tumor size are highly variable, with the exception of solid pseudopapillary tumor.
  • [MeSH-major] Pancreatic Cyst / diagnosis. Pancreatic Cyst / pathology. Pancreatic Cyst / surgery
  • [MeSH-minor] Cystadenoma, Serous / diagnosis. Cystadenoma, Serous / pathology. Cystadenoma, Serous / surgery. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatectomy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Retrospective Studies. Time Factors

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  • (PMID = 20601810.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 25
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37. Salama M, Ormonde D, Quach T, Ee H, Yusoff I: Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience. J Gastroenterol Hepatol; 2010 Jan;25(1):84-9
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  • [Title] Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience.
  • BACKGROUND AND AIMS: Endoscopic resection of large colorectal neoplasms is increasingly being used as an alternative to surgery.
  • The aim of the study was to report short- and long-term outcomes from endoscopic resection of large colorectal neoplasms from a single centre and use a model to predict mortality had surgery been performed.
  • METHODS: Consecutive patients referred for endoscopic resection of large (> or = 20 mm) colorectal neoplasms from January 2001 to February 2008 were included.
  • Resection details were recorded in a prospectively maintained database.
  • RESULTS: There were 154 large neoplasms in 140 patients.
  • Mean neoplasm size was 26 mm (range 20-80 mm, 24 > or = 40 mm).
  • CONCLUSION: Endoscopic resection of large colorectal neoplasms is safe and effective even for very large benign neoplasms.
  • [MeSH-major] Colectomy. Colonoscopy. Colorectal Neoplasms / surgery

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  • (PMID = 19793173.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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38. Lollar KW, Pollak N, Liess BD, Miick R, Zitsch RP 3rd: Schwannoma of the hard palate. Am J Otolaryngol; 2010 Mar-Apr;31(2):139-40
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  • Schwannomas are rare, benign neoplasms that can arise from any cranial, peripheral, or autonomic nerve that contains Schwann cells.
  • We report a case of schwannoma of the hard palate, present important pathologic considerations for diagnosis, and provide a review of the literature regarding extracranial schwannomas.
  • [MeSH-major] Neurilemmoma / pathology. Palatal Neoplasms / pathology. Palate, Hard

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015725.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 6
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39. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • [Title] Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract.
  • This contrasts with other smooth muscle proteins (eg, h-caldesmon, alpha-smooth muscle actin, desmin, smooth muscle myosin), which are expressed in proliferative (early) stages of smooth muscle development and occasionally in other cell types (striated muscle, myofibroblasts, myoepithelial cells, pericytes).
  • Smoothelin expression in mesenchymal tumors of the gastrointestinal (GI) tract has not been evaluated earlier.
  • The purpose of this study was to determine whether immunostaining for smoothelin could help distinguish smooth muscle neoplasms from their morphologic mimics, particularly KIT-negative gastrointestinal stromal tumors (GISTs), desmin-positive GISTs, and desmoid fibromatosis.
  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • Cytoplasmic expression of smoothelin was present in all 24 (100%) benign smooth muscle tumors (mural leiomyomas and leiomyomas of the muscularis mucosae).
  • In contrast, only 4 (24%) GI LMS showed cytoplasmic staining for smoothelin.
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • Interestingly, 7 (41%) GI LMS and 12 (22%) GISTs (all except 2 with an epithelioid component) showed multifocal, exclusively nuclear staining for smoothelin.
  • Nuclear expression of smoothelin was not detected in any of the other tumor types examined.
  • In summary, diffuse cytoplasmic staining for smoothelin is highly sensitive and specific for benign leiomyomas of the GI tract.
  • Aberrant nuclear expression is common in GI LMS and may also be seen in GISTs, especially epithelioid and mixed-type tumors.
  • These findings suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract, and may be useful in distinguishing leiomyomas from KIT-negative and/or desmin-positive GISTs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cytoskeletal Proteins / analysis. Gastrointestinal Neoplasms / chemistry. Muscle Proteins / analysis. Smooth Muscle Tumor / chemistry
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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40. Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A: Fine needle aspiration cytology (FNAC) and neck swellings in the surgical outpatient. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):30-2
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  • Tuberculous lymphadenitis was the commonest diagnosis (36%) followed by reactive/non-specific lymphadenitis (18%).
  • Other pathologies were malignant neoplasms (14%), cysts (10%), benign neoplasms (8%) and sialadenitis (6%).
  • CONCLUSION: It is concluded that tuberculous lymphadenitis is still the commonest condition in patients presenting with neck swellings followed by non-specific lymphadenitis and malignant neoplasms especially metastatic carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Head and Neck Neoplasms / pathology. Outpatients. Salivary Gland Diseases / pathology. Tuberculosis, Lymph Node / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19610510.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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41. Bhople KS, Joshi AR, Patil SP, Tembhare PR: Microcystic adenoma of pancreas: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):334-6
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  • Microcystic adenomas of the pancreas are rare benign neoplasms that occur most frequently in elderly females.
  • Characteristically, the tumors have a spongy gross appearance and are composed of innumerable cysts lined by flat, and cuboidal cells which are rich in glycogen.
  • In this case report, we present a cystic neoplasm of pancreas in a 65-year-old lady who clinically presented with discomfort in the abdomen and hyperglycaemia.
  • Histopathological examination of surgical specimen confirmed the diagnosis of "Microcystic Adenoma ofPancreas".
  • Despite of the rarity, microcystic adenoma should kept in the mind as the differential diagnosis of cystic lesions of pancreas.
  • [MeSH-major] Adenoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Pancreatectomy

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  • (PMID = 17883062.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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42. Akbulut S, Senol A, Cakabay B, Sezgin A: Giant renal oncocytoma: a case report and review of the literature. J Med Case Rep; 2010;4:52
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  • INTRODUCTION: Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms.
  • Oncocytomas are mostly asymptomatic, and the majority of tumors are discovered incidentally.
  • In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.
  • CASE PRESENTATION: We describe a 25-year-old Turkish woman who was admitted to our hospital with abdominal pain and a 3-year palpable abdominal mass, which was found present since her second pregnancy.

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  • (PMID = 20205900.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827435
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43. Wang RC, Barber AE, Ditmyer M, Vantine P: Distal facial nerve exposure: a key to partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jun;140(6):875-9
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  • 2) Be able to incorporate other modifications of parotidectomy including preservation of the great auricular nerve, superficial musculo-aponeurotic system (SMAS), and parotid duct.
  • STUDY DESIGN: Case series with chart review of partial parotidectomy for benign neoplasms and intraparotid lymph nodes, using antegrade (Group 1) or distal (Group 2) facial nerve exposure, and those conserving the great auricular nerve, SMAS, and parotid duct (Group 3).
  • [MeSH-major] Facial Nerve / anatomy & histology. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19467407.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Modlin IM, Shapiro MD, Kidd M: An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg; 2005 Jan;29(1):92-101
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  • [Title] An analysis of rare carcinoid tumors: clarifying these clinical conundrums.
  • Carcinoid tumors are distinct neuroendocrine neoplasms with characteristic histological, clinical, and biological properties.
  • Though commonly associated with the gastrointestinal tract and bronchopulmonary system, a substantial number of these tumors originate in less common anatomical sites and can range from indolent, unrecognized entities to highly active, metastatic secretory tumors.
  • The authors reviewed 13,715 carcinoid tumors identified by three consecutive registries of the National Cancer Institute (NCI) from 1950 to 1999, focusing on the anatomic sites accounting for less than one percent of all carcinoids.
  • In addition, data from the world's literature published on carcinoid tumors within these particular anatomic locations were then analyzed with respect to incidence, clinical presentation, symptoms, diagnostic evaluation, microscopic and immunohistochemical findings, treatment strategies, and prognosis.
  • The primary organs in which carcinoids are most commonly mistaken for some of the more conspicuous endemic tumors include the esophagus, pancreas, liver, biliary tract, gallbladder, and Meckel's diverticulum, as well as within the pelvic and otolaryngeal organs and the breast.
  • In general, the highest proportion of "rare" carcinoids was identified in the gastrointestinal (GI) tract, with the ovary as the single most affected extra-GI site.
  • Tumors with the worst prognosis were those that involved the pancreas (37.5%: 5-year survival) and those in the cervix (12-33%: 3-year survival).
  • While gastrointestinal carcinoids have become a more recognized entity and thus more amenable to identification, similar lesions are often not considered in other sites and have often either been overlooked or misdiagnosed.
  • The diminution of the likelihood of inadvertently neglecting these often benign, indolent neoplasms that are well known to metastasize if unaddressed would represent an important advance.
  • Familiarity with such unusual sites of origin will facilitate appropriate recognition and characterization of such tumors, allowing for timely intervention.
  • [MeSH-major] Carcinoid Tumor / surgery
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic. Breast Neoplasms / surgery. Esophageal Neoplasms / surgery. Female. Gallbladder Neoplasms / surgery. Humans. Laryngeal Neoplasms / surgery. Liver Neoplasms / surgery. Male. Ovarian Neoplasms / surgery. Pancreatic Neoplasms / surgery. Testicular Neoplasms / surgery. Uterine Cervical Neoplasms / surgery

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  • (PMID = 15599742.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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45. Marques YM, de Lima Mde D, de Melo Alves Sde M Jr, Soares FA, de Araújo VC, Pinto Ddos S Jr, Mantesso A: Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland. Oral Oncol; 2008 Sep;44(9):903-8
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  • [Title] Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
  • In the absence of p53 mutations, p53 inactivation is possible via complex formation with other proteins, such as Mdm2.
  • The pAkt protein is closely related to Mdm2, and has not been previously reported in salivary gland tumors.
  • Overexpression of Mdm2 and pAkt was present in all the cell lines and tumors studied, whereas the expression of p53 and p21 proteins was considered absent.
  • In conclusion, the signaling pathway in benign salivary gland neoplasm showed an important participation of Mdm2 overexpression protein in tumor formation, progression through inactivation of p53 action, or both, and of pAkt overexpression through increased translocation of Mdm2 protein to cellular nuclei.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-mdm2 / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Cell Line, Tumor. Genes, p53 / genetics. Humans. Immunohistochemistry. Mutation. Signal Transduction / genetics

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  • (PMID = 18485798.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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46. Ardigo M, Zieff J, Scope A, Gill M, Spencer P, Deng L, Marghoob AA: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology; 2007;215(4):354-8
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  • BACKGROUND: Trichoepitheliomas (TE) are benign neoplasms of follicular differentiation.
  • RCM showed oval, darker-appearing tumor islands that contained brightly refractile material, consistent with keratin horn cysts at the center, as well as parallel bundles of highly refractile dermal collagen surrounding the tumor islands.
  • The RCM findings in TE of keratin-filled cysts in tumor islands and attachment of the tumor to follicular structures have not been previously observed in BCC, and thus may also be diagnostically helpful.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy / methods. Head and Neck Neoplasms / pathology. Microscopy, Confocal. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17911996.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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47. Sandoval GA, Levinton C, Blackstien-Hirsch P, Brown AD: Selecting predictors of cancer patients' overall perceptions of the quality of care received. Ann Oncol; 2006 Jan;17(1):151-6
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  • Two main subgroups were analyzed in this study: patients with malignant and benign neoplasms.

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  • (PMID = 16236755.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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48. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54
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  • [Title] Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs.
  • This paper deals with a population-based material collected during the years 1990-1998, and comprises 439 tumours and tumour-like vascular processes from 420 dogs.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • More than one half (242 of 439) occurred in the skin, and a great majority of skin processes (223 of 242) represented benign tumours or tumour-like lesions.
  • The next most common site of summarised lesions was the spleen, with 110 cases, with only 17 processes in this organ being defined as benign.
  • Most tumour-like proliferations were papillary endothelial hyperplasias.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-major] Dog Diseases / pathology. Vascular Neoplasms / veterinary

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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49. Micchelli ST, Vivekanandan P, Boitnott JK, Pawlik TM, Choti MA, Torbenson M: Malignant transformation of hepatic adenomas. Mod Pathol; 2008 Apr;21(4):491-7
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  • Hepatic adenomas are benign neoplasms of the liver that occur in several well-defined clinical settings, but principally that of excess hormone exposure.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Contraceptives, Oral, Hormonal / adverse effects. Female. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / biosynthesis. alpha-Fetoproteins / biosynthesis. beta Catenin / genetics

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  • (PMID = 18246041.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / Tumor Suppressor Protein p53; 0 / alpha-Fetoproteins; 0 / beta Catenin
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50. Goyal P: Advances in endoscopic resection of sinonasal neoplasms. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):277-84
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  • [Title] Advances in endoscopic resection of sinonasal neoplasms.
  • A wide variety of pathology can now be surgically managed with the use of endoscopes both within and beyond the sinonasal tract.
  • Endoscopic techniques allow for excellent visualization and complete tumor resection with low morbidity.
  • As experience continues to grow, endonasal endoscopic techniques are becoming the surgical procedures of choice for the management of a wide variety of benign neoplasms.

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  • (PMID = 23120725.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450232
  • [Keywords] NOTNLM ; Endoscopic surgery / Inverted papilloma / Juvenile nasopharyngeal angiofibroma / Nasal tumors / Sinonasal neoplasms
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51. Carpizo DR, Allen PJ, Brennan MF: Current management of cystic neoplasms of the pancreas. Surgeon; 2008 Oct;6(5):298-307
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  • [Title] Current management of cystic neoplasms of the pancreas.
  • The majority of these cysts represent benign neoplasms; however, a significant fraction of these are pre-malignant or malignant.
  • Because the majority of these neoplasms are benign, many reports have advocated a selective approach to surgical resection.
  • Here we review the literature that has contributed to the development of our approach to the management of these cystic neoplasms.
  • We provide an overview of the key features in diagnosis and in predicting malignancy.
  • Particular attention is given to the natural history and management of intraductal papillary mucinous neoplasms (IPMN).
  • [MeSH-major] Cystadenoma / surgery. Pancreatic Cyst / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Diagnostic Imaging. Humans

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  • (PMID = 18939378.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 51
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52. Catalano O, De Lutio di Castelguidone E, Nunziata A, De Rosa V, Siani A: Gastrointestinal stromal tumours: Pictorial review. Radiol Med; 2005 Nov-Dec;110(5-6):484-91
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  • [Title] Gastrointestinal stromal tumours: Pictorial review.
  • Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the alimentary tract.
  • GISTs are immunohistochemically identified by the expression of the c-kit protein, which is not detected in other mesenchymal tumours.
  • The role of imaging includes the detection (subjects with occult gastrointestinal bleeding, incidental recognition, etc.
  • ), characterisation, analysis of relations between mass and gastrointestinal wall, staging, prognostic assessment (recognition of signs of malignancy and unfavourable prognosis), and follow-up during specific treatment.
  • Imaging findings usually allow differentiation from gastrointestinal epithelial tumours but not from non-epithelial tumours, for which histological confirmation is necessary, in part to verify potential response to therapy.
  • Smaller lesions, which are usually benign, tend to be well-defined, relatively homogeneous, and with intraluminal growth.
  • Larger lesions normally show well-defined or ill-defined margins, inhomogeneous density both on unenhanced and on contrast-enhanced scans, with combined intraluminal/extraluminal growth and a tendency to spread to surrounding structures.
  • Signs of high-grade GIST include liver metastasis, gastrointestinal wall infiltration, large volume, irregular surface, ill-defined margins, inhomogeneous enhancement and peritoneal spread.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Neoplasm Metastasis / radiography. Tomography, X-Ray Computed

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  • (PMID = 16437034.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 19
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53. Thomas L, Uppal HS, Kaur S, David VC: Inflammatory pseudotumour of the maxillary sinus presenting as a sino-nasal malignancy. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):61-3
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  • Inflammatory pseudotumours are a rare group of benign neoplasms of unknown aetiology.
  • A report is made of a 27-year-old female who presented with a rapid-onset proptosis that clinically and radiologically mimicked an aggressive sino-nasal malignancy.
  • [MeSH-major] Granuloma, Plasma Cell / diagnostic imaging. Granuloma, Plasma Cell / pathology. Magnetic Resonance Imaging. Maxillary Sinus Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 14986022.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • This multicentre study involved 28 Italian ORL Centres responding to a questionnaire sent by us which allowed recruitment of a high large number of cases of parotid neoplasms observed over a 10-year period.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Adenoid-cystic carcinoma was observed in 15.3% and < or = 10% for all the other most frequent histological malignant neoplasms.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • Enucleoresection was limited to approximately 15% of neoplasms, enucleation to <10% of cases with only 2% of pleomorph adenoma due to the well-known anatomo-pathological characteristics which may lead to relapse.
  • For malignant neoplasms, total parotidectomy was performed in approximately 50% of cases, while in the remaining 50% an almost equal rate of superficial parotidectomy was carried out and enlarged parotidectomy, with or without sacrificing the facial nerve, which was rebuilt in 60% of cases.
  • Sentinel lymph node was observed in a limited number of centres.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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55. Cullen KA, Hall MJ, Golosinskiy A: Ambulatory surgery in the United States, 2006. Natl Health Stat Report; 2009 Jan 28;(11):1-25
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  • Females had significantly more ambulatory surgery visits (20.0 million) than males (14.7 million), and a significantly higher rate of visits (132.0 per 1000 population) compared with males (100.4 per 1000 population).
  • The leading diagnoses at ambulatory surgery visits included cataract (3.0 million); benign neoplasms (2.0 million), malignant neoplasms (1.2 million), diseases of the esophagus (1.1 million), and diverticula of the intestine (1.1 million).

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  • (PMID = 19294964.001).
  • [ISSN] 2164-8344
  • [Journal-full-title] National health statistics reports
  • [ISO-abbreviation] Natl Health Stat Report
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Koay MH, Goh YW, Iacopetta B, Grieu F, Segal A, Sterrett GF, Platten M, Spagnolo DV: Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases. Pathology; 2005 Feb;37(1):22-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases.
  • AIMS: Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established.
  • (1) appropriate morphology, (2) CD117 positivity, (3) adequacy of pathological material for study, and (4) exclusion of other tumour types on the basis of immunophenotypic and/or ultrastructural features.
  • RESULTS: There were equal numbers of males and females with a mean age at diagnosis of 60 years, followed up for a mean of 54 months.
  • Size > or = 10 cm, tumour necrosis and pure epithelioid cell morphology each were the only factors significantly associated with adverse survival (p=0.038, and p=0.047 and p=0.028, respectively).
  • Mitotic activity > or = 5/50 HPF showed a definite trend association with adverse survival, but unlike some other studies, did not achieve statistical significance (p=0.067).
  • CD117 staining of any mesenchymal lesion of the gastrointestinal tract should be mandatory for accurate classification.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 15875730.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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57. Bakker JR, Haber MM, Garcia FU: Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. Am Surg; 2005 Feb;71(2):100-5
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  • [Title] Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction.
  • NF-1 is known to be associated with gastrointestinal neoplasms in 2-25 per cent of patients.
  • We report the first case of gastric outlet obstruction with perforation caused by neurofibroma in a patient with NF-1.
  • The literature is reviewed, examining 61 previously reported cases of noncarcinoid gastrointestinal (GI) neoplasms in patients with NF-1 for symptoms, location, and types of neoplasms.
  • Neoplasms were located most often in the small intestine (72%).
  • Neurofibromas, found in 52 per cent of patients, were the most frequently diagnosed benign neoplasms followed by leiomyomas (13%), ganglioneurofibromas (9.8%), and gastrointestinal stomal tumor (GIST) (6.5%).
  • Patients with NF-1 and GI symptoms are at risk for gastrointestinal neoplasms from which symptomatic patients are likely to experience significant morbidity.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Neurofibromatosis 1 / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Granulation Tissue / pathology. Humans. Male. Peptic Ulcer Perforation / etiology. Peptic Ulcer Perforation / pathology

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  • (PMID = 16022006.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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58. Fleming DM, Cross KW, Barley MA: Recent changes in the prevalence of diseases presenting for health care. Br J Gen Pract; 2005 Aug;55(517):589-95
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  • Age-standardised prevalence rates per 10,000 registered persons and 99% confidence intervals (CIs) were calculated using the national census population for 2001 as the standard.
  • Survey differences in prevalence were identified from non-overlapping CIs.
  • Particular increases were noted for other malignant and benign neoplasms of the skin, hypothyroidism and diabetes.

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  • (PMID = 16105366.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1463227
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59. Lee EJ, Kim TD, Oh HA, Lee HC, Kim JH, Jang BI, Kim TN, Chung MK, Bae YK: [Is the invasive approach for all the upper gastrointestinal mesenchymal tumors necessary?]. Korean J Gastroenterol; 2005 Jun;45(6):387-93
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  • [Title] [Is the invasive approach for all the upper gastrointestinal mesenchymal tumors necessary?].
  • BACKGROUND/AIMS: Mesenchymal tumors are the most frequent submucosal tumors in gastrointestinal trail.
  • We reviewed the mesenchymal tumors which are confirmed by pathology to examine whether the invasive approach of all mesenchymal tumors is necessary.
  • METHODS: This study was performed on fifty-nine patients who has mesenchymal tumors confirmed by endoscopic or surgical resection from January 2000 to June 2004.
  • RESULTS: Mesenchymal tumors consisted of thirty-six gastrointestinal stromal tumors (GISTs), 20 leiomyomas and 3 schwannomas.
  • All the esophageal tumors were leiomyoma (12/12, 100%).
  • Tumors less than 1 cm in maximal diameter were leiomyoma or GISTs with very low risk of aggressive behavior.
  • 56.1% of the tumors larger than 1 cm consisted of low, intermediate or high risk GISTs.
  • CONCLUSIONS: Biopsy must be considered according to its size and anatomic location of mesenchymal tumors.
  • The invasive approach for every esophageal submucosal tumor is not necessary unless the size is very large, because most of them are benign in nature.
  • However, the gastric submucosal tumor with more than 1 cm in diameter should be carefully and regularly followed up or biopsied because it cannot be assumed to be benign for any GIST more than 1 cm in size at the present time, safely.
  • [MeSH-major] Biopsy, Needle. Gastrointestinal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology
  • [MeSH-minor] Adult. Aged. Endoscopy, Gastrointestinal. Female. Humans. Leiomyoma / pathology. Male. Middle Aged. Neurilemmoma / pathology. Upper Gastrointestinal Tract

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  • (PMID = 15973072.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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60. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C: Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg; 2007 Apr;142(4):347-54
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  • [Title] Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.
  • OBJECTIVE: To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs).
  • Insulinomas were the most common type of functional neoplasm (33.3%), followed by gastrinomas and glucagonomas; 12 patients (7.1%) had multiple endocrine neoplasia type 1.
  • Of the neoplasms, 107 (63.7%) were located in the pancreatic body or tail.
  • We classified 76.8% of neoplasms as benign; of those classified as malignant, 25.6% had liver metastases.
  • Incidentally discovered nonfunctioning neoplasms were significantly more frequent in the last 5 years (60.4% vs 40.3%; P = .007), with a trend toward smaller neoplasms (mean, 4.2 cm vs 5.6 cm; P = .19) and lesser likelihood of malignancy (21.8% vs 40.0%; P = .08).
  • Increasing numbers of PNENs are being resected, largely owing to the incidental detection of nonfunctioning neoplasms.
  • This may lead to the treatment of smaller and less malignant neoplasms.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hospitals, General. Humans. Male. Massachusetts / epidemiology. Middle Aged. Retrospective Studies. Survival Rate / trends. Treatment Outcome

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  • (PMID = 17438169.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK071329; United States / NCI NIH HHS / CA / P01 CA117969
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS519098; NLM/ PMC3979851
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61. Khanna A, Koniaris LG, Nakeeb A, Schoeniger LO: Laparoscopic spleen-preserving distal pancreatectomy. J Gastrointest Surg; 2005 May-Jun;9(5):733-8
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  • Distal pancreatectomy with spleen preservation may be the preferred procedure for certain benign tumors and cystic lesions of the pancreatic body or tail.
  • [MeSH-major] Cystadenoma, Serous / surgery. Laparoscopy / methods. Pancreatectomy / methods. Pancreatic Cyst / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Length of Stay. Pain, Postoperative / diagnosis. Risk Assessment. Spleen / surgery. Treatment Outcome

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  • (PMID = 15862272.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Kaza RK, Azar S, Al-Hawary MM, Francis IR: Primary and secondary neoplasms of the spleen. Cancer Imaging; 2010;10:173-82
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  • [Title] Primary and secondary neoplasms of the spleen.
  • With the exception of lymphoma involving the spleen, other primary and secondary neoplasms are rare and infrequently encountered.
  • Primary malignant neoplasms involving the spleen are lymphoma and angiosarcoma.
  • Primary benign neoplasms involving the spleen include hemangioma, lymphangioma, littoral cell angioma and splenic cyst and solid lesions such as hamartoma and inflammatory pseudotumor.
  • [MeSH-major] Diagnostic Imaging. Splenic Diseases / diagnosis
  • [MeSH-minor] Cysts / diagnosis. Granuloma, Plasma Cell / diagnosis. Hamartoma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Lymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology

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  • (PMID = 20713317.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 38
  • [Other-IDs] NLM/ PMC2943678
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63. Landi B, Palazzo L: The role of endosonography in submucosal tumours. Best Pract Res Clin Gastroenterol; 2009;23(5):679-701
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  • Submucosal tumours (SMTs) are relatively common findings in patients undergoing endoscopy, especially in upper gastrointestinal (GI) tract.
  • This term includes various non-neoplastic and neoplastic conditions.
  • In this review, the following issues will be addressed: the endosonographic features of SMT; the diagnostic accuracy of EUS; the ability of EUS to distinguish benign and malignant SMTs; the value of EUS-guided fine-needle aspiration (FNA); and the influence of EUS on clinical management.
  • [MeSH-major] Endoscopy, Gastrointestinal. Endosonography. Gastrointestinal Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Mucous Membrane / ultrasonography. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 19744633.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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64. Paulino AC, Fowler BZ: Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol; 2005 Mar;22(2):89-101
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  • [Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.
  • This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.
  • From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.
  • The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.
  • Twenty-three (5.4%) patients developed a secondary neoplasm.
  • There were 14 malignant neoplasms in 13 (3.0%) and 14 benign neoplasms in 11 patients (2.6%).
  • The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.
  • For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.
  • The 14 second malignant neoplasms (SMN) were osteosarcoma in 3, breast carcinoma in 2, melanoma in 2, malignant fibrous histiocytoma in 1, dermatofibrosarcoma in 1, leiomyosarcoma in 1, mucoepidermoid carcinoma in 1, colon cancer in 1, chronic myelogenous leukemia in 1, and basal cell carcinoma in 1.
  • The 5- and 10-year overall survival rate after diagnosis of an SMN was 69.2%; it was 70% for children with a SMN at the edge or inside the RT field and 66.7% for those outside of the RT field.
  • The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.
  • Only 5 (36%) of the 14 benign tumors occurred in the RT field, with osteochondroma being the most common.
  • More than two-thirds of children with a radiation-induced malignancy are alive 10 years after the diagnosis of a SMN.
  • [MeSH-major] Neoplasms / radiotherapy. Neoplasms, Second Primary / etiology. Radiotherapy / adverse effects


65. Eisenberg D, Bell R: Intraoperative endoscopy: a requisite tool for laparoscopic resection of unusual gastrointestinal lesions--a case series. J Surg Res; 2009 Aug;155(2):318-20
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  • [Title] Intraoperative endoscopy: a requisite tool for laparoscopic resection of unusual gastrointestinal lesions--a case series.
  • BACKGROUND: Laparoscopy is increasingly becoming a preferred approach to surgery of the gastrointestinal tract.
  • Proper localization of small benign tumors is essential for precise non-anatomical excisions and remains difficult with the laparoscopic approach due to the greatly diminished tactile feedback.
  • METHODS: Between July 2006 and June 2007, 4 patients underwent resection of benign small gastrointestinal lesions.
  • Gastric lesions included pancreatic heterotopia, a gastrointestinal stromal tumor, and a Dieulafoy's lesion.
  • The cecal lesion was a granular cell tumor.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Gastrointestinal Tract / pathology. Gastrointestinal Tract / surgery. Intraoperative Period. Laparoscopy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cecal Neoplasms / pathology. Cecal Neoplasms / surgery. Female. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Humans. Male

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  • (PMID = 19482295.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Lito P, Pantanowitz L, Marotti J, Aboulafia DM, Campbell V, Bower M, Dezube BJ: Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series. Am J Med Sci; 2009 Jan;337(1):1-4
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  • [Title] Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series.
  • BACKGROUND: Non-AIDS-defining cancers are an important problem in HIV-infected patients.
  • The occurrence of neuroendocrine (NE) tumors in sites other than the lung and skin has not been well characterized in the setting of concurrent HIV infection.
  • METHODS: HIV-positive patients with biopsy-confirmed NE tumors localized to the gastrointestinal tract were identified based on the personal archives of the authors.
  • RESULTS: We identified 4 adult patients, mean age 42 years (range: 37-47) infected with HIV, who developed NE tumors originating in their gastrointestinal tact.
  • A specialized diagnostic work-up was required, including serum chromogranin and urinary 5-hydroxyindoleacetic acid levels, colonoscopy, radioactive isotope scans, and the demonstration of NE differentiation in procured pathologic material.
  • The spectrum of tumors ranged from benign (typical carcinoid) to highly aggressive neoplasms (NE carcinoma).
  • CONCLUSIONS: These cases serve to broaden the spectrum of neoplasms that may be encountered in the current HIV era, and illustrate the difficulty in establishing the diagnosis of NE tumors in the context of HIV infection.
  • [MeSH-major] Gastrointestinal Neoplasms / etiology. HIV Infections / complications. Neuroendocrine Tumors / etiology. Pancreatic Neoplasms / etiology

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  • (PMID = 19155751.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Stany MP, Hamilton CA: Benign disorders of the ovary. Obstet Gynecol Clin North Am; 2008 Jun;35(2):271-84, ix
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  • [Title] Benign disorders of the ovary.
  • Most ovarian disorders are benign, with the majority being functional ovarian cysts and benign neoplasms.
  • Imaging can often aid in diagnosis and risk assessment.
  • Benign ovarian disorders are frequently incidental findings, but they may cause symptoms from hormonal overproduction, mass effects, or torsion.
  • Knowledge of the cause, presentation, and natural history of these benign ovarian disorders helps providers counsel and treat patients appropriately.
  • [MeSH-major] Ovarian Cysts. Ovarian Neoplasms. Ovary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 18486841.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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68. Restrepo CS, Martinez S, Lemos DF, Washington L, McAdams HP, Vargas D, Lemos JA, Carrillo JA, Diethelm L: Imaging appearances of the sternum and sternoclavicular joints. Radiographics; 2009 May-Jun;29(3):839-59
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  • Pectus excavatum and pectus carinatum are common congenital anomalies that are usually benign but may warrant surgical treatment if they cause compression of vital internal structures.
  • In addition, sternal malignancies (most commonly, metastases and chondrosarcoma) must be distinguished from benign neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Arthritis / radiography. Bone Neoplasms / radiography. Dislocations / radiography. Female. Fractures, Bone / radiography. Funnel Chest / radiography. Humans. Male. Middle Aged. Osteomyelitis / radiography. Postoperative Complications / radiography. Young Adult

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  • (PMID = 19448119.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 88
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69. McGraw TA, Norton SA: Military aeromedical evacuations from central and southwest Asia for ill-defined dermatologic diseases. Arch Dermatol; 2009 Feb;145(2):165-70
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  • Outside the combat zone, these individuals were examined by dermatologists who provided a diagnosis regarded as correct for the purposes of this study.
  • Data from January 1, 2003, through December 31, 2006, were obtained from aeromedical evacuation records and the military's electronic medical records system.
  • PATIENTS: A total of 170 patients evacuated from the combat zone for ill-defined dermatologic diseases, such as skin disorder, not otherwise specified (International Classification of Diseases, Ninth Revision, Clinical Modification code 709.9).
  • MAIN OUTCOME MEASURES: The postevacuation diagnosis assigned, in nearly all cases, by a board-certified dermatologist.
  • RESULTS: Dermatitis, benign melanocytic nevus, malignant neoplasms, benign neoplasms, urticaria, and a group of nonspecific diagnoses were the most common postevacuation diagnoses.

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  • (PMID = 19221261.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Cigna E, Carlesimo B, Bistoni G, Conte F, Palumbo F, Scuderi N: The value of clinical diagnosis of digital glomus tumors. Acta Chir Plast; 2008;50(2):55-8
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  • [Title] The value of clinical diagnosis of digital glomus tumors.
  • Glomus tumors are benign neoplasms that differentiate from the glomus apparatus.
  • This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold.
  • The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and most commonly by ultrasound, with or without Doppler.
  • Surgical resection of the glomus tumor is the definitive treatment with resolution of all symptoms.
  • The nine most recent cases of glomus tumor underwent surgery after clinical assessment alone.
  • In our opinion clinical examination is the most effective method to diagnose this type of tumor and in selected cases it may be sufficient to undergo surgical therapy.
  • [MeSH-major] Angiography / methods. Fingers. Glomus Tumor / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18807392.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
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71. Sigurdardottir JM, Isaksson HJ, Johannsson KB, Jonsson S, Gudbjartsson T: [Histology does not accurately predict the clinical behaviour of bronchopulmonary carcinoids - results from an Icelandic population-based study]. Laeknabladid; 2008 Feb;94(2):125-30
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  • BACKGROUND AND AIMS: Bronchopulmonary carcinoids (BPC) are rare tumors of neuroendocrine origin.
  • These tumors are histologically classified into two distinctive forms, typical and the more malignant atypical BPC.
  • ), accounting for 1.9% of all lung neoplasms in Iceland.
  • Average tumor-diameter was 2.5 cm (range 0.4-5.5), with typical histology in 54 (84%) and atypical in 10 patients (16%).
  • CONCLUSION: BPCs usually behave as benign neoplasms, with excellent long-term survival after surgical removal.
  • Therefore, histology (typical vs. atypical) can not be used with certainty to predict the clinical behaviour of these tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Iceland / epidemiology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Population Surveillance. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18310777.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Iceland
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72. Dickson BC, Srigley JR, Pollett AF, Blackstein ME, Honey JD, Juco JW: Rectal gastrointestinal stromal tumor mimicking a primary prostatic lesion. Can J Urol; 2008 Jun;15(3):4112-4
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  • [Title] Rectal gastrointestinal stromal tumor mimicking a primary prostatic lesion.
  • The interstitial cells of Cajal have been identified in locations beyond the gastrointestinal tract, including the prostate, uterus and bladder.
  • Indeed, there are reports of primary gastrointestinal stromal tumor (GIST) arising from each of these sites.
  • We report the case of a 72-year old male who presented with benign prostatic hypertrophy and was diagnosed on retropubic prostatectomy as having a GIST.
  • While the initial clinical and radiologic impression was that of a primary prostatic GIST, subsequent imaging ultimately revealed a small rectal extension as the source of the lesion.
  • The purpose of our report is to highlight the need to assiduously rule-out gastrointestinal sources of GIST prior to making the diagnosis of primary prostatic GIST.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Prostatic Neoplasms / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18570720.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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73. Tei R, Morimoto T, Miyamoto K, Aketa S, Shimokawara T, Shin Y, Hironaka Y: Intradural extramedullary ganglioneuroma associated with multiple hamartoma syndrome. Neurol Med Chir (Tokyo); 2007 Nov;47(11):513-5
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  • She underwent right suboccipital craniectomy and C1-2 hemilaminectomy to remove the tumor.
  • She also suffered from multiple facial trichilemmomas, thyroid goiter, multiple polyposis of the gastrointestinal tract, and pulmonary hamartoma indicating multiple hamartoma syndrome.
  • These benign neoplasms were treated conservatively.
  • [MeSH-major] Ganglioneuroma / pathology. Hamartoma Syndrome, Multiple / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 18037807.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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74. Daum O, Hatlova J, Mandys V, Grossmann P, Mukensnabl P, Benes Z, Michal M: Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). Virchows Arch; 2010 May;456(5):491-7
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  • [Title] Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).
  • Vanek's tumor (inflammatory fibroid polyp) is a rare benign lesion occurring throughout the digestive tract.
  • Classical Vanek's tumor contains concentric formations of proliferating spindle cells which are CD34 positive.
  • Atypical, inflammatory pseudotumor-like Vanek's tumor lacks concentric formations and is CD34 negative.
  • Recently, mutations in platelet-derived growth factor receptor alpha (PDGFRA) were reported in gastric and small intestinal Vanek's tumors.
  • In this study, KIT exons 9, 11, 13, and 17, PDGFRA exons 12, 14, and 18, and a part of exon 15 BRAF for point mutation V600E were screened in 23 cases of Vanek's tumor, both classical (n = 16) and inflammatory pseudotumor-like (n = 7).
  • Six Vanek's tumors harbored activating mutations in PDGFRA exons 12 (n = 5) and 18 (n = 1) respectively: S566_E571delinsK (n = 1), S566_E571delinsR (n = 4), and D842 del (n = 1).
  • The mutations were detected in the classical (n = 5), as well as inflammatory pseudotumor-like (n = 1) Vanek's tumors.
  • The results of this study suggest that the two morphological patterns of Vanek's tumor more probably represent only variants of one type of tumor than two different lesions.
  • Furthermore, BRAF mutations were not shown to drive growth of PDGFRA wild-type Vanek's tumors.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Exons. Female. Gastrointestinal Tract / pathology. Humans. Male. Middle Aged. Mutation. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 20393746.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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75. Hakverdi S, Kalaci A, Yaldiz M, Akansu B: Glomus tumor of the hip. An unusual location. Saudi Med J; 2009 Feb;30(2):299-301
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  • [Title] Glomus tumor of the hip. An unusual location.
  • Glomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities.
  • The histopathologic diagnosis was a glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Hip. Soft Tissue Neoplasms / pathology

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  • (PMID = 19198725.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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76. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • Immunohistochemical study showed positivity only for vimentin and factor XIIIa, whereas pan-keratins, actin, desmin, CD34, CD10, and S-100 protein were negative.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • Four tumors involved the skull base; 2 of these underwent preoperative embolization.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The average size of the tumors was 5.8 cm x 2.7 cm with all tumors at least 2.5 cm in greatest dimension by computed tomography or magnetic resonance imaging.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.
  • CONCLUSION: Large vascular neoplasms of the sinonasal cavity, such as hemangiomas and hemangiopericytomas, can be safely removed using endoscopic techniques.
  • [MeSH-major] Endoscopy / methods. Hemangioma / surgery. Hemangiopericytoma / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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78. Takahashi Y, Suzuki M, Fukusato T: Plexiform angiomyxoid myofibroblastic tumor of the stomach. World J Gastroenterol; 2010 Jun 21;16(23):2835-40
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  • [Title] Plexiform angiomyxoid myofibroblastic tumor of the stomach.
  • Plexiform angiomyxoid myofibroblastic tumor of the stomach is a unique mesenchymal tumor that we first described in 2007.
  • The tumor is very rare, and to date, only 18 cases confirmed by immunohistochemistry have been reported in the literature.
  • Representative clinical symptoms are ulceration, associated upper gastrointestinal bleeding (hematemesis), and anemia.
  • The tumors are located at the antrum in all cases, and grossly, the tumor is whitish to brownish or reddish, and forms a lobulated submucosal or transmural mass.
  • Microscopically, the tumor is characterized by a plexiform growth pattern, the proliferation of cytologically bland spindle cells, and a myxoid stroma that is rich in small vessels and positive for Alcian blue stain.
  • Immunohistochemically, the tumor cells are positive for alpha-smooth muscle actin and negative for KIT and CD34.
  • Differential diagnoses include gastrointestinal stromal tumor and other mesenchymal tumors of the gastrointestinal tract.
  • Some authors proposed that this tumor should be designated as "plexiform fibromyxoma", but this designation might cause confusion.
  • The tumor is probably benign and thus far, neither recurrence nor metastasis has been reported.
  • [MeSH-major] Fibroma / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA Mutational Analysis. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / diagnosis. Humans. Immunohistochemistry. Male. Mesenchymoma / diagnosis. Middle Aged. Young Adult

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  • (PMID = 20556828.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial; Review
  • [Publication-country] China
  • [Number-of-references] 24
  • [Other-IDs] NLM/ PMC2887578
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79. Melichar B, Solichová D, Freedman RS: Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):240-52
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  • Malignant tumors may contribute to host response that involves both the adaptive and innate immune systems.
  • Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin.
  • In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders.
  • Elevated levels of neopterin have also been observed in the tumor microenvironment.
  • Elevated neopterin has also been connected with depressed function of peripheral blood lymphocytes and a decrease in CD4+ T-cell numbers.
  • [MeSH-major] Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / therapy. Immunotherapy / methods. Neopterin / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / analysis. Endometrial Neoplasms / immunology. Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / immunology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Uterine Cervical Neoplasms / immunology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16445639.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 670-65-5 / Neopterin
  • [Number-of-references] 134
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80. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • PATIENT: A case of a large MPNST is reported, which originated in the left temporalis muscle of a 74-year-old man who did not suffer from von Recklinghausen's disease.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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81. Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology; 2010 Dec;139(6):2072-2082.e5
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  • [Title] Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
  • BACKGROUND & AIMS: CD166 (also called activated leukocyte cell adhesion molecule [ALCAM]) is a marker of colorectal cancer (CRC) stem cells; it is expressed by aggressive tumors.
  • Although the presence of CD166 at the tumor cell surface has been correlated with shortened survival, little is known about its function and expression in normal intestinal epithelia.
  • Human and mouse intestinal tumors were also analyzed.
  • CD166 was located in the cytoplasm and at the surface of cells within human CRC tumors.
  • CD166-positive cells were also detected in benign adenomas in mice; rare cells coexpressed CD166 and CD44 or epithelial-specific antigen.
  • CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20826154.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118235; United States / NIDDK NIH HHS / DK / U01 DK085525-02; United States / NHLBI NIH HHS / HL / T32 HL007781; United States / NCI NIH HHS / CA / CA106195-06A1; United States / NCI NIH HHS / CA / CA118235-05; United States / NICHD NIH HHS / HD / T32 HD049309-05; United States / NCI NIH HHS / CA / CA106195; United States / NCI NIH HHS / CA / T32 CA106195; United States / NICHD NIH HHS / HD / HD049309; United States / NICHD NIH HHS / HD / T32 HD049309; United States / NCI NIH HHS / CA / T32 CA106195-06A1; United States / NHLBI NIH HHS / HL / T32 HL007781-14; United States / NIDDK NIH HHS / DK / R01 DK068326; United States / NCI NIH HHS / CA / CA118235; United States / NIDDK NIH HHS / DK / R01 DK068326-05; United States / NIDDK NIH HHS / DK / DK068326; United States / NIDDK NIH HHS / DK / DK085525-02; United States / NICHD NIH HHS / HD / HD049309-05; United States / NHLBI NIH HHS / HL / HL007781-14; United States / NHLBI NIH HHS / HL / HL007781; United States / NIDDK NIH HHS / DK / U01 DK085525; United States / NIDDK NIH HHS / DK / DK085525; United States / NIDDK NIH HHS / DK / DK068326-05; United States / NCI NIH HHS / CA / R01 CA118235-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS234467; NLM/ PMC2997177
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82. Aminian A, Noaparast M, Mirsharifi R, Bodaghabadi M, Mardany O, Ali FA, Karimian F, Toolabi K: Ileal intussusception secondary to both lipoma and angiolipoma: a case report. Cases J; 2009;2:7099
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  • Lipoma and angiolipoma are common benign neoplasms that occur in the subcutaneous tissue and rarely in the gastrointestinal tract.
  • These tumors are usually asymptomatic but may present with abdominal pain, bleeding and obstruction.
  • Histopathological study showed that one was angiolipoma and other lesions were lipoma.
  • We have described some aspects of diagnosis and treatment of this rare cause of intestinal intussusception.

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  • (PMID = 19829910.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740257
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83. Calbo L, Sciglitano P, Calbo E, Niceta M, Borzì R, Sofia L, Plutino F, Gorgone S: [Carotid body tumor. An often misdiagnosed disease]. G Chir; 2009 Apr;30(4):144-7
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  • [Title] [Carotid body tumor. An often misdiagnosed disease].
  • Chemodectomas are uncommon neoplasms, born by glomic cell of extra-adrenegic system.
  • Usually, these neoplasms are benign and non functioning, but when they are more than 4 cm can induce a neuro-vascular compressive syndrome.
  • In this study the Authors propose the guidelines for diagnostic, clinical and therapeutic management, of these tumors according to their experience.
  • [MeSH-major] Carotid Body Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 19419614.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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84. Bordi C, D'Adda T, Azzoni C, Pizzi S, Bottarelli L, Mormandi F, Antonetti T, Luong TV, Rindi G: Criteria for malignancy in gastrointestinal endocrine tumors. Endocr Pathol; 2006;17(2):119-29
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  • [Title] Criteria for malignancy in gastrointestinal endocrine tumors.
  • In contrast with the large amount of data generated from endocrine tumors of the pancreas, sparse and mostly unconfirmed data are available on the criteria for the assessment of malignancy risk and patient outcome in endocrine tumors of the gastrointestinal tract.
  • In these conditions the 2000 WHO classification with its standardized scheme of pathologic report constitutes a framework facilitating the assessment of tumor malignancy and has been regarded as useful for clinical purposes, providing the basis for proper management of the patients and for the design of treatment protocols.
  • The classification is based on a combination of pathological and clinical features with parameters specific for each organ in which the endocrine tumors originate.
  • (1) well-differentiated endocrine tumors, further subdivided into tumors with benign and with uncertain behavior;.
  • In this review the differential tumor characteristics between the different categories are summarized.
  • Moreover, the relevance of additional features with respect to tumor prognostication, chiefly the Ki-67 proliferation index and malignancy-associated genetic changes, is discussed with emphasis on the discrepancies emerging between tumors of foregut and of midgut origin.
  • [MeSH-major] Endocrine Gland Neoplasms / classification. Endocrine Gland Neoplasms / diagnosis. Gastrointestinal Neoplasms / classification. Gastrointestinal Neoplasms / diagnosis. Neoplasm Invasiveness / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Ki-67 Antigen. Mitotic Index. Prognosis. World Health Organization

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  • (PMID = 17159244.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  • [Number-of-references] 51
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85. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Jaw bone metastases: four cases. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Mar;16(1):21-5
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  • OBJECTIVE: Metastatic tumors make up approximately one percent of all oral malignancies.
  • Such tumors may present in the jaw bones and oral soft tissues.
  • The commonest oral site is the mandible.
  • PATIENTS AND METHODS: This is a retrospective study of four cases of metastatic tumors of the jaws seen at the Oral-Maxillofacial Department, General University Hospital of Alexandroupolis, Thrace, Greece from 1989 to 2005, representing 1% of all histologically confirmed malignant tumors at the hospital.
  • The oral symptoms were similar to odontogenic infections or to benign neoplasms.
  • CONCLUSIONS: In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
  • [MeSH-major] Adenocarcinoma / secondary. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology

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  • [RetractionIn] Papadopoulos N. Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):143 [19784531.001]
  • (PMID = 17992450.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Slovenia
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86. Ponsaing LG, Kiss K, Hansen MB: Classification of submucosal tumors in the gastrointestinal tract. World J Gastroenterol; 2007 Jun 28;13(24):3311-5
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  • [Title] Classification of submucosal tumors in the gastrointestinal tract.
  • This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors.
  • Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors.
  • In the past there has been some confusion as to the classification of gastrointestinal submucosal tumors.
  • Literature searches were performed to find information related to classification of gastrointestinal submucosal tumors.
  • Based on these searches the twelve most frequent submucosal tumor types were chosen for description of their classification.
  • The factors that indicate whether tumors are benign or malignant are mainly size and number of mitotic counts.
  • Gastrointestinal stromal tumors are defined mainly by their CD117 positivity.
  • In the future, there should be no more confusion between gastrointestinal stromal tumors and other types of submucosal tumors.
  • [MeSH-major] Gastrointestinal Neoplasms / classification
  • [MeSH-minor] Antigens, CD34 / analysis. Gastric Mucosa / pathology. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Intestinal Mucosa / pathology. Proto-Oncogene Proteins c-kit / analysis

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  • (PMID = 17659669.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC4172710
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87. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4
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  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • Under a presumptive diagnosis of sialadenitis/sialolithiasis, the patient was administered multiple courses of antibiotics; however, these were not effective.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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88. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • Our current data provide a basis for continued investigation of certain mtDNA variants as predictors of the three adenomatous polyps in a larger number of clinicopathological specimens.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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89. Lopes J, Hochwald SN, Lancia N, Dixon LR, Ben-David K: Autoimmune esophagitis: IgG4-related tumors of the esophagus. J Gastrointest Surg; 2010 Jun;14(6):1031-4
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  • [Title] Autoimmune esophagitis: IgG4-related tumors of the esophagus.
  • We present a case of a 23-year-old gentleman who presented with dysphagia, weight loss, and recurrent esophageal strictures requiring multiple dilatations.
  • Fine needle aspiration suggested that the mass in the lower esophagus resembled a gastrointestinal stromal tumor.
  • After surgical resection, final pathologic analysis revealed that the tumor was comprised of benign-appearing fibroinflammatory cells with an increase and predominance of IgG4-positive plasma cells.
  • The microscopic appearance was consistent with a benign condition as a result of an IgG4-related process.
  • He did not, however, have any other symptoms indicative of systemic autoimmune disease or connective tissue disorders.
  • We present the pre-operative imaging, operative management, pathologic diagnosis, and literature review of this rare condition and the first known report of autoimmune esophagitis as part of the IgG4 spectrum of diseases.

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  • (PMID = 20195914.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin G
  • [Number-of-references] 14
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90. Ge C, Luo X, Chen X, Guo K: Enucleation of pancreatic cystadenomas. J Gastrointest Surg; 2010 Jan;14(1):141-7
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  • BACKGROUND: Optimal surgical treatment of pancreatic cystadenomas is controversial due to the rarity of the tumors and paucity of studies regarding long-term outcomes.
  • (1) the benign nature of the tumors was ascertained preoperatively and intraoperatively, (2) small tumors or larger tumors no more than 6 cm in diameter growing outwardly with small tumor beds, and (3) the main pancreatic duct was not in jeopardy of damage by enucleation.
  • The patients' demographics, tumor features, morbidity, and follow-up results were retrospectively reviewed and analyzed.
  • RESULTS: Among 11 cases, three were serous cystadenomas and eight were mucinous cystadenomas; the average size of the neoplasms was 4.8 cm (ranging from 3 to 6 cm).
  • All cases were followed up from 23 to 67 months, which revealed no neoplasm recurrence or new onset of diabetes mellitus; one patient developed a pseudocyst in the body 30 months after enucleation.
  • CONCLUSIONS: It is safe and effective to perform enucleation for well-selected benign pancreatic cystadenomas even if the tumor size is as large as 6 cm, and the endocrine or exocrine function of the pancreas is maintained as much as possible.
  • [MeSH-major] Cystadenoma, Mucinous / surgery. Cystadenoma, Serous / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 19779948.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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91. Kitajima K, Shiba H, Nojiri T, Uwagawa T, Ishida Y, Ichiba N, Yanaga K: Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor. J Gastrointest Surg; 2007 Mar;11(3):398-402
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  • Magnetic resonance images raised strong suspicion of a benign lesion, such as an inflammatory pseudotumor, while the other radiological studies were equivocal.
  • Furthermore, the high-intensity image on diffusion magnified-weighted imaging with a low B value strongly suggested a benign tumor.
  • The diagnosis of peripheral ICC rich in fibrous tissue seems to require needle biopsy for pathological examination with immunohistochemical staining because it frequently mimics other diseases, including benign tumors.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Granuloma, Plasma Cell / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17458614.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Demonte F, Moore BA, Chang DW: Skull base reconstruction in the pediatric patient. Skull Base; 2007 Feb;17(1):39-51
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  • Tumors of the skull base are rare in children and adolescents and present a complicated management problem for oncologists and surgeons alike.
  • Surgical resection is an integral component of the management of many pediatric neoplasms, especially those that are benign or, though not frankly malignant, are locally invasive.
  • The general principles of skull base reconstruction following tumor ablation are applicable to nearly all patients; the reconstructive algorithm, however, is particularly complex in the pediatric population and the potential benefits of therapy must be balanced against the cumulative impact on craniofacial growth and maturity and the donor site morbidity.
  • A retrospective analysis of all patients less than 19 years of age who underwent resection of a skull base tumor was performed.
  • Data were recorded on patient age, tumor pathology and location, prior therapies, surgical approach, extent of resection, margin status, defect components, details of reconstructive methods employed, complications, additional procedures or interventions, and the use and timing of adjuvant therapies.
  • Complications recorded included partial or total flap loss, cerebrospinal fluid leakage, meningitis, infection, abscess, hematoma or seroma formation, delayed healing, and donor site dysfunction.
  • On the basis of our experience and previous reports in the literature, we offer the following guidelines for the successful multidisciplinary care of children and adolescents undergoing skull base reconstruction after tumor resection:.

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  • (PMID = 17603643.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852573
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93. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol; 2005 Sep 7;11(33):5226-8
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  • [Title] Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report.
  • Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract.
  • Although rare, it is the most common primary tumor of the mesentery and can develop at any age.
  • We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST).
  • This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall.
  • Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16127758.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320401
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94. Brønden LB, Eriksen T, Kristensen AT: Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2010;52:6
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  • [Title] Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • BACKGROUND: The Danish Veterinary Cancer Registry (DVCR) was established in May 2005 to gather information about neoplasms in the Danish dog and cat populations.
  • The objectives of the current study were, with a special focus on mast cell tumours (MCT) to investigate the occurrence, gender distribution, biological behaviour, locations, types, the diagnostic method used and treatment of skin neoplasms in dogs based on information reported to the DVCR.
  • METHODS: From May 15th 2005 through February 29th 2008, reports on a total of 1,768 canine cases of neoplasia in the skin, subcutis or adnexa were submitted.
  • RESULTS: The majority of dogs had a benign neoplasm (66%) while 21% were cases of malignant neoplasia.
  • The most commonly encountered malignant neoplasms were MCT and soft tissue sarcomas and for benign neoplasms, lipomas and histiocytomas were the most common.
  • The location of the neoplasms were primarily in the cutis, subcutis or in the perianal region.
  • The occurrence, gender distribution, biological behaviour and location of canine skin neoplasias in Denmark were similar to earlier reports, although some national variations occurred.
  • CONCLUSIONS: Population based cancer registries like the DVCR are of importance in the collection of non-selected primary information about occurrence and distribution of neoplasms.
  • The DVCR provides detailed information on cases of skin neoplasms in dogs and may serve as a platform for the study of sub-sets of neoplastic diseases (e.g.
  • [MeSH-major] Dog Diseases / epidemiology. Mastocytosis / veterinary. Registries. Skin Neoplasms / veterinary

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  • (PMID = 20096110.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2823750
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95. Ronellenfitsch U, Staiger W, Kähler G, Ströbel P, Schwarzbach M, Hohenberger P: Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach. Diagn Ther Endosc; 2009;2009:286138
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  • [Title] Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach.
  • Background. Surgery remains the only curative treatment for gastrointestinal stromal tumour (GIST).
  • Resection needs to ensure tumour-free margins while lymphadenectomy is not required.
  • Follow-up was performed to obtain information on tumour recurrence.
  • Histology confirmed GIST in 17 cases, 4 tumours were benign neoplasms.

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  • (PMID = 19343179.001).
  • [ISSN] 1070-3608
  • [Journal-full-title] Diagnostic and therapeutic endoscopy
  • [ISO-abbreviation] Diagn Ther Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2662319
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96. Kolb A, Kleeff J, Frohlich B, Werner J, Friess H, Büchler MW: Resection of the intrapancreatic bile duct preserving the pancreas. J Hepatobiliary Pancreat Surg; 2009;16(1):31-4
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  • Benign neoplasms of the distal bile duct are rare, but pose a therapeutic challenge.
  • Here, we present a case of an intrapancreatic benign neuroendocrine tumor that was resected by performing a pancreas-preserving distal bile duct resection.
  • First, a duodenotomy was carried out and a probe was inserted into the pancreatic duct to avoid inadvertent injury.
  • The duodenal incision was closed, and reconstruction was performed by an end-to-side hepaticojejunostomy and a Roux-Y jejunojejunostomy.
  • In conclusion, pancreas-preserving distal bile duct resection might be an option for intrapancreatic benign lesions of the distal bile duct that would otherwise require a partial pancreaticoduodenectomy.
  • [MeSH-major] Carcinoma, Neuroendocrine / surgery. Pancreas / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Bile Ducts / pathology. Cholangiopancreatography, Magnetic Resonance. Digestive System Surgical Procedures. Humans. Male. Middle Aged

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  • (PMID = 19089312.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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97. Versaci A, Macrì A, Ieni A, Terranova M, Leonello G, Saladino E, Speciale G, Famulari C: [Gastrointestinal stromal tumour: our experience]. Chir Ital; 2009 Mar-Apr;61(2):161-9
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  • [Title] [Gastrointestinal stromal tumour: our experience].
  • [Transliterated title] I tumori stromali gastrointestinali (GIST): nostra esperienza.
  • Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
  • The symptoms of GIST are non-specific and depend on the size and location of the lesion.
  • Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture.
  • GISTs are classified as tumours with low- and high-risk of malignancy, depending on tumour size and mitotic count.
  • Tumour site and acute onset are also significant parameters for prognostic purposes.
  • Histological examinations documented 6 benign tumours and 9 malignancies.
  • One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively.
  • [MeSH-major] Gastrointestinal Stromal Tumors / drug therapy. Gastrointestinal Stromal Tumors / surgery. Stomach Neoplasms / drug therapy. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Benzamides. Chemotherapy, Adjuvant. Colonic Neoplasms / drug therapy. Colonic Neoplasms / surgery. Female. Follow-Up Studies. Humans. Ileal Neoplasms / drug therapy. Ileal Neoplasms / surgery. Imatinib Mesylate. Jejunal Neoplasms / drug therapy. Jejunal Neoplasms / surgery. Male. Middle Aged. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19536989.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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98. Okur E, Yildirim I, Bakariş S, Okur N, Kiliç MA: [Pilomatrixoma of the head and neck in six cases]. Kulak Burun Bogaz Ihtis Derg; 2005;14(5-6):121-6
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  • Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and neck region.
  • The lesions were located in the preauricular region in two cases, and in the periorbital region, the forehead, the neck, and in the dorsum of the nose in the other patients, respectively.
  • Histopathologic diagnosis was pilomatrixoma.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Tomography, X-Ray Computed


99. Woo VL, Angiero F, Fantasia JE: Myoepithelioma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 May;99(5):581-9
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  • Soft tissue myoepitheliomas, in contrast to salivary gland myoepitheliomas, are benign neoplasms that typically occur in the soft tissues of the extremities.
  • Both are characterized by a multilobular proliferation of polygonal to fusiform cells embedded in a variably myxoid to chondromyxoid matrix.
  • A histologically similar lesion that has a marked predilection for the anterior dorsum of the tongue has been referred to as ectomesenchymal chondromyxoid tumor.
  • The morphological and immunohistochemical resemblance of soft tissue myoepitheliomas to ectomesenchymal chondromyxoid tumors has led to the use of these designations interchangeably.
  • We present a case of myoepithelioma of the tongue and review the literature, with emphasis on the differential diagnosis and histogenesis of this lesion and pertinent nosologic considerations.
  • [MeSH-major] Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Membrane Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 15829881.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 30
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100. Alberto VO, Kelleher D, Denholm RB, Nutt M, Carney JA: A calcified lung tumour and microcytic anaemia in a young woman: partial expression of the Carney triad. Surgeon; 2008 Aug;6(4):249-51
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  • [Title] A calcified lung tumour and microcytic anaemia in a young woman: partial expression of the Carney triad.
  • The Carney triad is the non-familial addociation of gastric stromal tumours (GISTs), pulmonar chondromas and extra-adrenal paragangliomas.
  • Fewer than 100 cases of the disorder have been reported since its description in 1977.
  • The tumours tend to be multifocal in the affected organ or system.
  • Herein, we describe the case of a 27-year-old woman with multiple gastric GISTs and a pulmonary chondroma, partial expression of the Carney triad.
  • It is important to be aware of the Carney triad when one of its constituent tumours is found, particularly if the patient is a young woman, so that a search can be made for and surveillance instituted for the other components.
  • The lung chondromas are benign neoplasms and ordinarily not symptomatic.
  • If a diagnosis of the tumour can be established by biopsy, surgical resection may not be necessary.
  • [MeSH-major] Anemia / complications. Calcinosis / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Radiography, Thoracic

  • MedlinePlus Health Information. consumer health - Anemia.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
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  • (PMID = 18697369.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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