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1. Brønden LB, Nielsen SS, Toft N, Kristensen AT: Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark. Vet Rec; 2010 May 8;166(19):586-90
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  • [Title] Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark.
  • From May 15, 2005 to April 15, 2008, 1878 cases of neoplasms in dogs were reported to the web-based Danish Veterinary Cancer Registry.
  • The proportions of malignant (38 per cent) and benign (45 per cent) tumours were similar.
  • The most common malignant neoplasms were adenocarcinomas (21 per cent), mast cell tumours (19 per cent) and lymphomas (17 per cent).
  • The benign neoplasms most commonly encountered were lipomas (24 per cent), adenomas (22 per cent) and histiocytomas (14 per cent).
  • Skin (43 per cent) and the female reproductive system including mammary tissue (28 per cent) were the most common locations of neoplasia.
  • There was a distinct breed predisposition for tumour development, with a high standard morbidity ratio (indicating a higher risk of cancer) for boxers and Bernese mountain dogs.
  • [MeSH-major] Dog Diseases / epidemiology. Neoplasms / veterinary. Pedigree. Registries / statistics & numerical data

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  • (PMID = 20453236.001).
  • [ISSN] 2042-7670
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Onder M, Adişen E: A new indication of botulinum toxin: leiomyoma-related pain. J Am Acad Dermatol; 2009 Feb;60(2):325-8
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  • Cutaneous leiomyomas are benign neoplasms with smooth muscle differentiation.
  • They are painful tumors of the skin.
  • Botulinum toxin has no known systemic adverse effects, and can be combined with other treatments without concern for drug interactions.
  • Like any other medication, aside from its actual pharmacologic effect, botulinum toxin may have had a placebo effect in our patient.
  • [MeSH-major] Botulinum Toxins / therapeutic use. Leiomyomatosis / complications. Pain / drug therapy. Pain / etiology. Skin Neoplasms / complications

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  • (PMID = 19150277.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; EC 3.4.24.69 / Botulinum Toxins
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3. Akhter J, Hirachand S, Lakhey M: Role of FNAC in the diagnosis of salivary gland swellings. Kathmandu Univ Med J (KUMJ); 2008 Apr-Jun;6(2):204-8
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  • [Title] Role of FNAC in the diagnosis of salivary gland swellings.
  • RESULTS: In this series of FNAC, 16 cases (40%) were benign neoplasms, 5 cases (12.5%) malignant neoplasms, non-neoplastic cysts 3 cases (7.5%) and inflammatory lesions 16 cases (40%).Histopathology was available in 24 cases out of which 22 cases correlated with cytology.
  • CONCLUSION: FNAC is useful in the diagnosis of salivary gland swellings especially in benign conditions with a sensitivity of 90% and specificity of 100%.
  • [MeSH-major] Biopsy, Fine-Needle. Cysts / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Sialadenitis / diagnosis

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  • (PMID = 18769087.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Nepal
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4. Lott S, Lopez-Beltran A, Maclennan GT, Montironi R, Cheng L: Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential. Hum Pathol; 2007 Jun;38(6):807-23
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  • [Title] Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential.
  • Most bladder tumors arise from the urothelium.
  • These include both benign and malignant spindle cell lesions.
  • The first half of this 2-part review will describe benign myofibroblastic proliferations including inflammatory myofibroblastic tumor and postoperative spindle cell nodule; benign neoplasms including leiomyoma, hemangioma, neurofibroma, and schwannoma; and tumors of uncertain malignant potential including paraganglioma, granular cell tumor, and perivascular epithelioid cell tumor.
  • This review also describes current theories as to the pathogenesis of inflammatory myofibroblastic tumor and postoperative spindle cell nodule and details the current molecular markers identifying several of these lesions.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 17509394.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 87
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5. Adams PD, Enders GH: Wnt-signaling and senescence: A tug of war in early neoplasia? Cancer Biol Ther; 2008 Nov;7(11):1706-11
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  • [Title] Wnt-signaling and senescence: A tug of war in early neoplasia?
  • Studies of early neoplasia have revealed fundamental molecular pathways that drive tumorigenesis.
  • We envision commonality of pathways important in formation of two early benign neoplasms that are found in different tissues and which are not generally thought to be similar: dysplastic nevi of the skin and intestinal aberrant crypt foci.
  • We propose that these neoplasms result from an ongoing 'tug of war' between the tumor suppression barrier posed by cellular senescence and the tumor-promoting activity of Wnt-signaling.
  • Whether or not such neoplasms progress to malignancy or persist in a benign state for many years might be largely determined by the outcome of this tug of war and its modulation by other genetic and epigenetic alterations, such as inactivation of p16(INK4a).

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  • (PMID = 18836285.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK64758; United States / NIGMS NIH HHS / GM / R01 GM062281; United States / NIGMS NIH HHS / GM / GM062281-08; United States / NCI NIH HHS / CA / R01CA129334-01; United States / NCI NIH HHS / CA / R01 CA129334-01A1; United States / NCI NIH HHS / CA / CA129334-01A1; United States / NIA NIH HHS / AG / AG031862-010002; United States / NIA NIH HHS / AG / P01 AG031862; United States / NCI NIH HHS / CA / R01 CA129334; United States / NIDDK NIH HHS / DK / R01 DK064758; United States / NIDDK NIH HHS / DK / DK064758-06; United States / NIDDK NIH HHS / DK / R01 DK064758-06; United States / NIA NIH HHS / AG / P01 AG031862-010002; United States / NIGMS NIH HHS / GM / R01 GM062281-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Other-IDs] NLM/ NIHMS80646; NLM/ PMC2783518
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6. Fine SW, Chan TY, Epstein JI: Inverted papillomas of the prostatic urethra. Am J Surg Pathol; 2006 Aug;30(8):975-9
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  • Inverted papillomas of the genitourinary tract are uncommon benign neoplasms usually occurring in the urinary bladder and less frequently in the upper urinary tract.
  • Patients had a mean age of 65.1 years (range: 30 to 89 y), with 10/21 (47.6%) presenting with gross hematuria (n = 8) or irritative symptoms (n = 2) related to the inverted papilloma and 11/21 (52.4%) detected incidentally during work-up/treatment of prostate cancer (n = 6) or benign prostatic hypertrophy (BPH) (n = 5).
  • The remaining cases showed foci of squamous metaplasia with moderate atypia (n = 4), rare true papillary fronds in a classic inverted papilloma background (n = 2), or both (n = 1).
  • Eleven cases with prostatic tissue revealed adenocarcinoma of the prostate [n = 6; Gleason score 6 (n = 3) or 7 (n = 3)], high-grade prostatic intraepithelial neoplasia (n = 1), benign prostatic hypertrophy (n = 3), or adenosis (n = 1).
  • No patients had a prior history of either inverted papilloma or urothelial carcinoma, whereas 2 patients were diagnosed with high-grade urothelial carcinoma of the bladder synchronous with their inverted papilloma diagnosis.
  • None of the other patients had local recurrences or recurrences at other locations in the urinary tract (mean follow-up 39.9 mo; range: 3 to 120 mo).
  • Inverted papillomas of the prostatic urethra are benign lesions that are commonly detected incidentally and are not associated with a history of urothelial malignancy.
  • Although urothelial carcinoma elsewhere in the genitourinary tract may occur simultaneously, malignant transformation or recurrence as a malignant lesion has not been identified in inverted papilloma of the prostatic urethra.
  • [MeSH-major] Papilloma, Inverted / pathology. Prostate / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Humans. Incidental Findings. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Prognosis. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16861968.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Awadalla F, Rosenbaum DA, Camacho F, Fleischer AB Jr, Feldman SR: Dermatologic disease in family medicine. Fam Med; 2008 Jul-Aug;40(7):507-11
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  • The five most common skin disorders diagnosed by family physicians were dermatitis, pyoderma, tinea, benign neoplasms, and candida.
  • [MeSH-major] Family Practice / statistics & numerical data. Skin Diseases / diagnosis

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  • (PMID = 18928078.001).
  • [ISSN] 0742-3225
  • [Journal-full-title] Family medicine
  • [ISO-abbreviation] Fam Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Glucocorticoids; 0 / Histamine H1 Antagonists; 0 / Sunscreening Agents
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8. Kamate B, Traore CB, Diallo D, Foko I, Sangare F, Malle B, Coulibaly B, Mounkoro N, Bayo S: [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases]. Mali Med; 2008;23(3):36-9
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  • [Title] [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases].
  • [Transliterated title] Epidemiologie et morphologie des tumeurs benignes du sein au Mali: a propos de 186 cas.
  • BACKGROUND: Mammary tumors are frequent.
  • Benign tumors are more frequent, and are characterized by a possibility of recurrence or malignant transformation.
  • The aim of this study was to describe the epidemiological and morphological characteristics of breast benign tumors.
  • The study had concerned all benign tumors confirmed by histology.
  • FINDINGS: In total, 186 benign tumors were diagnosed over 611 mammary pathologies (30.44%).
  • Tumor sizes were variable, and the color changed through white to yellow.
  • Histological aspects were: fibroadenoma (72%), lipoma (8.6%), tubular adenoma (5.9%), papilloma (5.4%), lactating adenoma (3.8%), phyllodes tumor (3.8%), and syringomatous tumor (0.5%).
  • CONCLUSION: Benign tumors are frequent in mammary pathology.
  • The patients need a follow-up because of the recurrence or the malignant transformation of these tumors.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / pathology

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  • (PMID = 19617151.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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9. Lortscher DN, Sengelmann RD, Allen SB: Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome. Dermatol Online J; 2007;13(2):21
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  • Basal cell nevus syndrome is an autosomal dominant disorder characterized by multiple basal cell carcinomas, along with numerous other documented clinical features.
  • Acrochordons (or skin tags) are common benign neoplasms that are appropriately left untreated in most patients.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Risk Assessment

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  • (PMID = 17498440.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • Lipomas are common benign neoplasms of adipose tissue.
  • This case occurred in a 77-year-old woman who developed multiple lipomas two years after beginning treatment with pioglitazone, a PPAR gamma agonist.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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11. Figueroa-Torres Y, Martínez-Ojeda JA, Franqui-Rivera H, Martínez-Toro J: Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean. P R Health Sci J; 2008 Dec;27(4):373-6
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  • [Title] Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean.
  • INTRODUCTION: Neoplasms of the heart are extremely rare and difficult to diagnose.
  • In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms.
  • A total of 77 cases with a diagnosis of Benign Heart Neoplasm were found from 1992 to 2008 but only those with an official pathologic report (n = 43) were considered.
  • The clinical charts provided data related to age, sex, presenting symptoms, non-invasive and invasive characteristics, surgical procedures, and pathological findings.
  • RESULTS: The mean age for diagnosis was 51.49 years.
  • The most common location of the mass was the left atrium (81%) and overall, the most common heart neoplasm in this study was myxoma (83.7%).
  • CONCLUSIONS: This study of a total of 43 pathologically confirmed benign cardiac neoplasms admitted to the Cardiovascular Center of Puerto Rico and the Caribbean from 1992 to 2008 validates the fact that heart neoplasms represent a fairly rare diagnosis.
  • It is also consistent with previously published series that establish myxoma as the most common of these benign neoplasms.
  • [MeSH-major] Heart Neoplasms / diagnosis

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  • (PMID = 19069370.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
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12. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9
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  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology
  • [MeSH-minor] Adenocarcinoma / genetics. Breast Neoplasms / genetics. Endometrial Neoplasms / genetics. Female. Goiter, Nodular / genetics. Humans. Lymphangioma / etiology. Mastectomy. Middle Aged. Postoperative Complications / etiology

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  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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13. Havu-Aurén K, Kiiski J, Lehtiö K, Eskola O, Kulvik M, Vuorinen V, Oikonen V, Vähätalo J, Jääskeläinen J, Minn H: Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. Eur J Nucl Med Mol Imaging; 2007 Jan;34(1):87-94
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  • Boron neutron capture therapy (BNCT) is a chemically targeted form of radiotherapy requiring increased concentration of boron-10 in tumour tissue.
  • [(18)F]FBPA uptake in tumour and brain was assessed with a three-compartmental model and graphical analysis.
  • These, together with standardised uptake values (SUVs), were used to define tumour-to-brain [(18)F]FBPA tissue activity gradients.
  • RESULTS: Model fits with three parameters K (1) (transport), k (2) (reverse transport) and k (3) (intracellular metabolism) were found to best illustrate [(18)F]FBPA uptake kinetics.
  • Maximum SUV was two- to fourfold higher in tumour as compared with normal brain and independent of NF2 status.
  • The increased uptake was due to higher transport of [(18)F]FBPA in tumour.
  • In multiple-time graphical analysis (MTGA, Gjedde-Patlak plot) the tumour-to-brain [(18)F]FBPA influx constant (K (i) -MTGA) ratios varied between 1.8 and 5.4 in NF2-associated tumours while in sporadic tumours the ratio was 1-1.4.
  • Based on our results on tumour uptake of [(18)F]FBPA, some of these benign neoplasms may be amenable to BNCT.
  • [MeSH-major] Boron Compounds / pharmacokinetics. Brain Neoplasms / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Neurilemmoma / metabolism. Neurofibromatoses / metabolism. Phenylalanine / analogs & derivatives

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  • (PMID = 16896669.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiopharmaceuticals; 133921-60-5 / 4-borono-2-fluorophenylalanine; 47E5O17Y3R / Phenylalanine
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14. Maes L, Lippens E, Kalala JP, de Ridder L: The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas. Cell Prolif; 2005 Feb;38(1):3-12
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  • [Title] The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas.
  • Meningiomas are considered as benign neoplasms affecting the coverings of the central nervous system and compromise approximately 20% of all intracranial tumours.
  • The interdependence between tumour recurrence and cell proliferation in this study is analysed by Ki-67 immunoreactivity (clone MIB-1).
  • Archival material from 29 non-recurrent and 32 recurrent tumours has been evaluated, including specimens from World Health Organization (WHO) stages I (n = 73), II (n = 2) and III (n = 12).
  • Although the tumours were categorized as benign meningiomas following the WHO classification, recurrence in 22 of 50 cases did not correlate with the tumour stage.
  • For hTERT staining, the following results were found for nucleolar and total nuclear staining, respectively: non-recurrent meningiomas, 2.9% (+/- 7.7) and 3.0% (+/- 8.0); recurrent meningiomas at first resection, 16.8% (+/- 19.7) and 31.6% (+/- 30.2).
  • Concerning the Ki-67 labelling index (LI): for the group of non-recurrent meningiomas, results were 2.1% (+/- 1.7) and for the recurrent group at first resection, 1.7% (+/- 2.0).
  • A significant difference was seen for the hTERT staining (P < 0.001) between the non-recurrent and recurrent meningiomas, whereas no statistical significance was found for Ki-67.
  • [MeSH-major] Antigens, Neoplasm. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Telomerase / biosynthesis

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  • (PMID = 15679862.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 2.7.7.49 / Telomerase
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15. Kulkarni N, Andrews SJ, Rao V, Rajagopal KV: Case report: Benign porta hepatic schwannoma. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):213-5
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  • [Title] Case report: Benign porta hepatic schwannoma.
  • Schwannoma is a myelin sheath tumor that can occur almost anywhere in the body.
  • The most common locations are the central nervous system, extremities, neck, mediastinum and retroperitoneum.
  • Benign schwannomas in the porta hepatis are extremely rare and radiologically are diagnosed as either enlarged lymph nodes or bowel masses, such as gastrointestinal stromal tumors.
  • The preoperative diagnosis can be extremely difficult.

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  • (PMID = 19881089.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766878
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16. Han MW, Lee BJ, Jang YJ, Chung YS: Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses. Otolaryngol Head Neck Surg; 2010 Sep;143(3):341-7
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  • [Title] Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses.
  • SUBJECTS AND METHODS: From January 1997 to August 2006, preoperative diagnosis was achieved using endoscopic incisional biopsy in 521 patients.
  • Cytopathologic and histologic findings were categorized as malignancy, benign neoplasm, or non-neoplastic lesion.
  • We investigated the accuracy of endoscopic incisional biopsy and preoperative imaging by comparing it with pathologic results from tumor resection as the "gold standard."
  • RESULTS: Most of the patients had unilateral nasal symptoms (e.g., nasal obstruction, unilateral epistaxis, unilateral facial pain), and the clinical symptoms were of little diagnostic value in the differentiation of tumor and inflammatory lesion.
  • The sensitivity and specificity of endoscopic incisional biopsy were 43.7 and 98.9 percent, respectively, for the diagnosis of nasal cavity malignancies, and 78.2 and 96.2 percent, respectively, for the diagnosis of benign neoplasms.
  • The sensitivity and specificity of preoperative imaging were 78.3 and 97.5 percent, respectively, for the diagnosis of nasal cavity malignancies and 66.4 and 86.3 percent, respectively, for the diagnosis of benign neoplasms.
  • CONCLUSION: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies.
  • [MeSH-major] Ambulatory Surgical Procedures. Biopsy / methods. Endoscopy. Nasal Cavity. Nose Neoplasms / pathology

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20723769.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON; 2008 Oct-Dec;13(4):581-4
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  • [Title] Glomus tumor of the stomach: a case report.
  • Glomus tumors are relatively uncommon benign neoplasms, most common in the skin and subcutaneous tissue, but can also occur in the viscera, most often in the stomach.
  • Preoperative diagnosis, when the tumor occurs in the stomach, seems difficult but is important, since glomus tumors of the stomach are essentially benign and amenable to conservative excision, contrary to aggressive gastric neoplasms.
  • We describe the case of a 75-year-old man presented to the emergency department with gastrointestinal bleeding and epigastric pain.
  • Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
  • Histological examination of the tumor confirmed the diagnosis of gastric glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19145686.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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18. Ozdamar SO, Bektaş S, Erdem Ozdamar S, Gedikoğlu G, Doğan Gün B, Bahadir B: Nuclear morphometric analysis in gastrointestinal stromal tumors: a preliminary study. Turk J Gastroenterol; 2007 Jun;18(2):71-6
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  • [Title] Nuclear morphometric analysis in gastrointestinal stromal tumors: a preliminary study.
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors are considered a specialized group of mesenchymal neoplasms.
  • In this study, the histomorphologic and immunohistochemical features of gastrointestinal stromal tumors are compared with nuclear morphometric results.
  • METHODS: Morphometric nuclear parameters such as mean area, mean roundness factor, mean form ellipse, mean length and mean perimeter were evaluated in hematoxylin and eosin stained slides of 22 gastrointestinal stromal tumors (9 benign and 13 malignant) by using a computer-assisted image analysis system.
  • Morphometric results were compared with tumor behavior and tumor size, the presence of necrosis, mitotic index, and immunohistochemical expressions of p53 and proliferating cell nuclear antigen.
  • RESULTS: We found that tumor necrosis was correlated with mean nuclear roundness factor, mean nuclear form ellipse, mean nuclear length and mean nuclear perimeter (p<0.05).
  • However, no correlation was found between morphometric features and gastrointestinal stromal tumor behavior, tumor size, or index of proliferating cell nuclear antigen and p53 expressions (p>0.05).
  • CONCLUSIONS: In this preliminary study, the relative concordance of the morphometric results and general histomorphologic data exhibited the importance of nuclear morphometric analysis in gastrointestinal stromal tumors.
  • Studies including larger series of cases investigating detailed nuclear morphometric analysis of gastrointestinal stromal tumors are needed.
  • [MeSH-major] Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology
  • [MeSH-minor] Adult. Aged. Digestive System Neoplasms / metabolism. Digestive System Neoplasms / pathology. Female. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Proliferating Cell Nuclear Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17602353.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
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19. Konstantinidis K, Theodoropoulos GE, Spanomihos G, Sambalis G, Vorias M, Georgiou M, Anastassakou K: Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):396-9
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  • [Title] Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding.
  • A 2.5 cm diameter, smooth, hypervascular tumor was easily visualized on the jejunal wall 10 cm from the ligament of Treitz.
  • The small bowel segment was laparoscopically mobilized and brought through the subumbilical trocar site, which was extended 1 cm.
  • A limited small bowel resection and a stapled anastomosis were easily performed extracorporeally.
  • Histopathologic examination diagnosed a benign gastrointestinal tumor (gastrointestinal stromal tumor, leiomyoma).
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Intestinal Neoplasms / complications. Intestinal Neoplasms / surgery. Leiomyoma / complications. Leiomyoma / surgery

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  • (PMID = 16108744.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Intussusception has been considered an operative indication in adults as a result of the risk of ischemia and the possibility of a malignant lead point.
  • Seven had,enteroenteric intussusceptions from benign neoplasms (two), adhesions (one), local inflammation (one), previous anastomosis (one), Crohn's disease (one), and idiopathic (one).
  • Of the 15 without intussusception at exploration, five had pathology related to trauma, four had nonincarcerated internal hernia after Roux-en-Y gastric bypass, four had negative explorations, one had adhesions, and one had appendicitis that did not correlate with CT findings.
  • All operative patients demonstrated gastrointestinal symptoms versus 55.3 per cent of the observation group (P < 0.006).
  • Most cases can be treated expectantly despite the presence of gastrointestinal symptoms.
  • Length and diameter of the intussusception, presence of a lead point, or bowel obstruction on CT are predictive of findings that warrant exploration.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women.
  • CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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22. Puggioni A, Delis KT, Fields CE, Viozzi CF, Kallmes DF, Gloviczki P: Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation. Perspect Vasc Surg Endovasc Ther; 2005 Mar;17(1):21-8
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  • [Title] Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation.
  • Carotid body tumors (CBT) are rare and usually benign neoplasms (60%-90%), originating from the mesoderm and neural ectoderm.
  • Despite progress in CBT imaging and surgical technique, cranial nerve deficit, stroke, and death continue to affect 10% to 40% of patients undergoing curative surgical resection, particularly in large tumors proximal to the skull base.
  • In such cases, CBT shrinkage by preoperative embolization, improved surgical access utilizing mandibular subluxation, and electroencephalographic monitoring combined with meticulous surgical technique may enable curative tumor resection, without prohibitive morbidity.
  • [MeSH-major] Carotid Body Tumor / surgery. Mandible / surgery

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  • (PMID = 15952693.001).
  • [ISSN] 1531-0035
  • [Journal-full-title] Perspectives in vascular surgery and endovascular therapy
  • [ISO-abbreviation] Perspect Vasc Surg Endovasc Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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24. Dinter DJ, Aramin N, Weiss C, Singer C, Weisser G, Schoenberg SO, Post S, Niedergethmann M: Prediction of anastomotic leakage after pancreatic head resections by dynamic magnetic resonance imaging (dMRI). J Gastrointest Surg; 2009 Apr;13(4):735-44
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  • PATIENTS AND METHODS: One hundred seven consecutive patients were identified in the departmental database and examined by means of a standardized dMRI protocol using a 1.5-T MRI system.
  • The more severe type B and C anastomotic leakages occurred only in the group of patients with SI(ratio) >or= 1.1.
  • Patients with a rapid increase had significantly better preoperative American Society of Anesthesiologists staging, lower carbohydrate antigen 19-9 values, and smaller tumor sizes.
  • Most of them had not only benign tumors but also longer postoperative hospital stay, in comparison to patients with delayed perfusion (SI(ratio) <1.1).
  • Patients with a SI(ratio) >or= 1.1 had a 7.9-fold increased risk of anastomotic leakage and a prolonged hospital stay.

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  • (PMID = 19057965.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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25. Krysiak R, Okopień B, Marek B, Szkróbka W: [Prolactinoma]. Przegl Lek; 2009;66(4):198-205
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  • Prolactin-secreting tumours (prolactinomas) are benign neoplasms constituting about 40 percent of all pituitary tumours.
  • Differential diagnosis of the disease should include the intake of various drugs, hypothyroidism, renal failure, liver cirrhosis, compression of the pituitary stalk by other pathologies, idiopathic hyperprolactinemia and other types of pituitary adenomas.
  • The aims of treatment are to restore or to achieve eugonadism through the normalisation of hyperprolactinemia and control of tumour mass.
  • The authors review the diagnosis and management of prolactinomas, including progress made in recent years.
  • [MeSH-major] Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy. Prolactinoma / diagnosis. Prolactinoma / therapy
  • [MeSH-minor] Adult. Age Distribution. Causality. Dopamine Agonists / therapeutic use. Female. Humans. Iatrogenic Disease / epidemiology. Male. Pregnancy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / epidemiology. Pregnancy Complications, Neoplastic / therapy. Prevalence. Sex Distribution. Young Adult

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  • (PMID = 19708510.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Dopamine Agonists
  • [Number-of-references] 53
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26. Muşat M, Morris DG, Korbonits M, Grossman AB: Cyclins and their related proteins in pituitary tumourigenesis. Mol Cell Endocrinol; 2010 Sep 15;326(1-2):25-9
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  • Pituitary tumours are benign neoplasms that may cause major endocrine dysfunction.
  • Nevertheless, molecular CDK inhibitors may play a role in pituitary tumour treatment in the future.
  • [MeSH-major] Cyclins / physiology. Pituitary Neoplasms / etiology
  • [MeSH-minor] Cell Cycle Proteins / metabolism. Cyclin E / metabolism. Cyclin E / physiology. Cyclin-Dependent Kinases / antagonists & inhibitors. Cyclin-Dependent Kinases / genetics. Humans. Multiple Endocrine Neoplasia Type 1 / genetics. Neoplasms. Pituitary Gland / metabolism. Pituitary Gland / pathology

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  • [Copyright] 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20347931.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / Cyclins; EC 2.7.11.22 / Cyclin-Dependent Kinases
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27. Yang WL, Zhang XC, Yan ZQ, Zhang HM, Zhao Z, Zhang JG, Wang YJ: [Clinical analysis of primary small intestinal neoplasms in 305 cases]. Zhonghua Zhong Liu Za Zhi; 2007 Oct;29(10):781-3
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  • [Title] [Clinical analysis of primary small intestinal neoplasms in 305 cases].
  • OBJECTIVE: To summarive the experience in diagnosis and treatment of primary small intestinal neoplasm.
  • METHODS: The data of 305 patients with pathologically confirmed primary small intestinal tumor collected from 6 hospitals around the Songhua River during the past 33 years were analyzed retrospectively.
  • RESULTS: There were 42 benign and 263 malignant tumors in this series with a ratio of 1: 6.26.
  • The 263 malignant tumors in this series consisted of 135 adenocarcinomas, 57 malignant stromal tumors, 37 malignant lymphomas, 20 carcinoids, and etc.
  • Chronic occult bleeding, gradual of body weight loss and mild abdominal pain (three obscurities) were the common clinical features and alerting massage of intestinal tumor.
  • Correct preoperative diagnostic rate was only 57.0% (174/305) due to difficulty in early diagnosis, which was 67.2% (92/137) in the duodenal tumors, and 51.9% (82/168) in the jejunoileal tumors.
  • All of the 42 benign tumors were resected completely.
  • For the 263 patients with malignant tumors, radical dissection was performed in 153, palliative resection in 34, and gut by-pass or biopsy in 76.
  • The median survival of the patients who underwent radical resection of their malignant tumors was 92 months, which was significantly higher than that of the other groups.
  • CONCLUSION: Early diagnosis of primary small intestinal tumors is difficult and with a preoperative misdiagnosis rate of 43.0%.
  • Total intestinal barium swallowing, endoscopy and superior mesenteric arteriography are three critical examinations for diagnosis and location.
  • The primary small intestinal tumor should be resected as early as possible if no distant metastasis is detected.
  • [MeSH-major] Adenocarcinoma. Diagnostic Errors. Digestive System Surgical Procedures / methods. Duodenal Neoplasms
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / diagnosis. Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Female. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / secondary. Gastrointestinal Stromal Tumors / surgery. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lymphatic Metastasis. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 18396694.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Baderca F, Cojocaru S, Lazăr E, Lăzureanu C, Faur A, Lighezan R, Alexa A, Raica M, Vălean M, Balica N: Schwannoma of the lip: case report and review of the literature. Rom J Morphol Embryol; 2008;49(3):391-8
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  • Schwannomas of the lip are rare, benign neoplasms which vary in size.
  • The diagnosis is typically made at the time of surgery following biopsy and surgical resection is the mainstay of treatment.
  • We present one case of lip schwannoma: the patient was 25-year-old and he has presented to otorhinolaryngologist for a non-dolorous tumor on the mucosal side of his inferior lip, which was increasing in size for the last six months.
  • The tumor had a superficial ulceration and infection.
  • The tumor was radically removed, and the sections were stained with Hematoxylin-Eosin.
  • The tumor was encapsulated and showed two different pattern of growth.
  • Verocay bodies, which were presented in Antoni A areas, are whorled formations of palisading tumor cells.
  • The cells of neoplasm were monotone.
  • In addition, immunohistochemical labeling was performed for S-100 protein, vimentin, GFAP and NSE and confirmed the diagnosis.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18758646.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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29. Pickhardt PJ, Kim DH, Meiners RJ, Wyatt KS, Hanson ME, Barlow DS, Cullen PA, Remtulla RA, Cash BD: Colorectal and extracolonic cancers detected at screening CT colonography in 10,286 asymptomatic adults. Radiology; 2010 Apr;255(1):83-8
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  • Benign neoplasms (including advanced colorectal adenomas), symptomatic lesions, and tumors without pathologic proof were excluded.
  • Extracolonic malignancies included renal cell carcinoma (n = 11), lung cancer (n = 8), non-Hodgkin lymphoma (n = 6), and a variety of other tumors (n = 11).
  • [MeSH-major] Colonography, Computed Tomographic. Colorectal Neoplasms / diagnostic imaging
  • [MeSH-minor] Adenoma / diagnostic imaging. Adenoma / pathology. Female. Humans. Kidney Neoplasms / diagnostic imaging. Kidney Neoplasms / pathology. Lung Neoplasms / diagnostic imaging. Lung Neoplasms / pathology. Lymphatic Metastasis. Lymphoma, Non-Hodgkin / diagnostic imaging. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Multiple Primary / pathology. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • [Copyright] RSNA, 2010
  • (PMID = 20308446.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA144835
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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30. Mohammed F, Asaria J, Payne RJ, Freeman JL: Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):340-6
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  • OBJECTIVE: To compare the trends and specific outcomes of patients treated surgically for parotid neoplasms between 1994 and 2005 with those of patients who were treated between 1985 and 1993 at Mount Sinai Hospital in Toronto and to identify preoperative indicators of malignancy.
  • Of these patients, 183 (75.6%) had benign neoplasms, 51 (21.1%) had malignant neoplasms, and 8 (3.3%) had inflammatory or lymphatic lesions.
  • Comparison of these results with the other study at our institution revealed no significant differences in patient predictors or outcomes.
  • CONCLUSIONS: These results were compared with those of a previous study conducted at the same institution between 1985 and 1993.
  • [MeSH-major] Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Facial Pain / diagnosis. Facial Pain / epidemiology. Facial Pain / etiology. Female. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Staging. Ontario / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Survival Rate / trends. Young Adult

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  • (PMID = 19128637.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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31. Kim HS, Yun KJ: Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology. Diagn Cytopathol; 2008 Apr;36(4):253-6
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  • [Title] Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.
  • Adenolipomas are rare benign neoplasms composed of mature adipose tissue and thyroid follicles.
  • A 65-year-old woman presented with a 4-month history of a thyroid nodule.
  • A FNA cytology specimen showed a few benign follicular cells with adipose tissue.
  • Microscopic findings showed a solid tumor predominantly composed of mature adipose tissue intermixed with thyroid follicles.
  • The pathological diagnosis was adenolipoma of the thyroid gland.
  • [MeSH-major] Lipoma / diagnosis. Thyroid Neoplasms / diagnosis

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335547.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Parra-Herran CE, Garcia MT, Herrera L, Bejarano PA: Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period. JOP; 2010;11(4):358-64
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  • [Title] Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period.
  • CONTEXT: Cystic lesions of the pancreas represent an important subgroup of pancreatic tumors.
  • SETTING: Cases were subclassified in diagnostic categories and were grouped according to the nature of the lesion (non-neoplastic vs. neoplastic).
  • Among the 97 cysts, five (5.2%) were non-neoplastic and 92 (94.8%) were neoplastic (59.8% benign, 17.5% borderline, 17.5% malignant).
  • Intraductal papillary mucinous neoplasm was the most common diagnosis (n=51; 52.6%) followed by serous cystic neoplasm (n=20; 20.6%) and mucinous cystic neoplasm (n=13; 13.4%).
  • Tumor size was significantly lower in benign neoplastic lesions (P=0.045).
  • Incidental identification was more frequent in benign lesions (P=0.028), whereas malignant lesions were more frequently symptomatic (P=0.001).
  • Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining.
  • Age at presentation, gender, location and tumor size are highly variable, with the exception of solid pseudopapillary tumor.
  • [MeSH-major] Pancreatic Cyst / diagnosis. Pancreatic Cyst / pathology. Pancreatic Cyst / surgery
  • [MeSH-minor] Cystadenoma, Serous / diagnosis. Cystadenoma, Serous / pathology. Cystadenoma, Serous / surgery. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatectomy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Retrospective Studies. Time Factors

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  • (PMID = 20601810.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 25
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33. Salama M, Ormonde D, Quach T, Ee H, Yusoff I: Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience. J Gastroenterol Hepatol; 2010 Jan;25(1):84-9
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  • [Title] Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience.
  • BACKGROUND AND AIMS: Endoscopic resection of large colorectal neoplasms is increasingly being used as an alternative to surgery.
  • The aim of the study was to report short- and long-term outcomes from endoscopic resection of large colorectal neoplasms from a single centre and use a model to predict mortality had surgery been performed.
  • METHODS: Consecutive patients referred for endoscopic resection of large (> or = 20 mm) colorectal neoplasms from January 2001 to February 2008 were included.
  • Resection details were recorded in a prospectively maintained database.
  • RESULTS: There were 154 large neoplasms in 140 patients.
  • Mean neoplasm size was 26 mm (range 20-80 mm, 24 > or = 40 mm).
  • CONCLUSION: Endoscopic resection of large colorectal neoplasms is safe and effective even for very large benign neoplasms.
  • [MeSH-major] Colectomy. Colonoscopy. Colorectal Neoplasms / surgery

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  • (PMID = 19793173.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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34. Lollar KW, Pollak N, Liess BD, Miick R, Zitsch RP 3rd: Schwannoma of the hard palate. Am J Otolaryngol; 2010 Mar-Apr;31(2):139-40
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  • Schwannomas are rare, benign neoplasms that can arise from any cranial, peripheral, or autonomic nerve that contains Schwann cells.
  • We report a case of schwannoma of the hard palate, present important pathologic considerations for diagnosis, and provide a review of the literature regarding extracranial schwannomas.
  • [MeSH-major] Neurilemmoma / pathology. Palatal Neoplasms / pathology. Palate, Hard

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015725.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 6
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35. Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A: Fine needle aspiration cytology (FNAC) and neck swellings in the surgical outpatient. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):30-2
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  • Tuberculous lymphadenitis was the commonest diagnosis (36%) followed by reactive/non-specific lymphadenitis (18%).
  • Other pathologies were malignant neoplasms (14%), cysts (10%), benign neoplasms (8%) and sialadenitis (6%).
  • CONCLUSION: It is concluded that tuberculous lymphadenitis is still the commonest condition in patients presenting with neck swellings followed by non-specific lymphadenitis and malignant neoplasms especially metastatic carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Head and Neck Neoplasms / pathology. Outpatients. Salivary Gland Diseases / pathology. Tuberculosis, Lymph Node / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19610510.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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36. Bhople KS, Joshi AR, Patil SP, Tembhare PR: Microcystic adenoma of pancreas: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):334-6
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  • Microcystic adenomas of the pancreas are rare benign neoplasms that occur most frequently in elderly females.
  • Characteristically, the tumors have a spongy gross appearance and are composed of innumerable cysts lined by flat, and cuboidal cells which are rich in glycogen.
  • In this case report, we present a cystic neoplasm of pancreas in a 65-year-old lady who clinically presented with discomfort in the abdomen and hyperglycaemia.
  • Histopathological examination of surgical specimen confirmed the diagnosis of "Microcystic Adenoma ofPancreas".
  • Despite of the rarity, microcystic adenoma should kept in the mind as the differential diagnosis of cystic lesions of pancreas.
  • [MeSH-major] Adenoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Pancreatectomy

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  • (PMID = 17883062.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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37. Bruno M, Carucci P, Repici A, Pellicano R, Mezzabotta L, Goss M, Magnolia MR, Saracco GM, Rizzetto M, De Angelis C: The natural history of gastrointestinal subepithelial tumors arising from muscularis propria: an endoscopic ultrasound survey. J Clin Gastroenterol; 2009 Oct;43(9):821-5
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  • [Title] The natural history of gastrointestinal subepithelial tumors arising from muscularis propria: an endoscopic ultrasound survey.
  • AIM: The majority of lesions originating from muscularis propria of stomach, duodenum, and colon are gastrointestinal stromal tumors (GISTs).
  • Surgery is indicated when endosonographic criteria of malignancy are met, but little is known about the natural history of lesions with benign endosonographic features.
  • Aim of this study was to evaluate the natural course of benign-appearing lesions originating from muscularis propria in organs where GISTs significantly overcome leiomyomas.
  • MATERIALS AND METHODS: A total of 49 asymptomatic patients with hypoechoic lesions originating from the fourth layer of the gastrointestinal tract entered a follow-up program by means of endoscopic ultrasonography.
  • RESULTS: After a mean follow-up of 31+/-20.8 months and a median of 2 (range, 1 to 5) endosonographies/patient, no change in echostructure or dimensions was seen in 44 subjects whereas in 5, an increase of at least 25% in 1 diameter occurred.
  • Surgical removal was proposed to all: 1 patient refused (she is still alive and symptom-free after 4 y), 3 of the 4 lesions removed proved to be GISTs with very low or low risk of malignancy and 1 lesion was classified as a glomus tumor with no malignant appearance.
  • CONCLUSIONS: Even small and benign-appearing lesions from muscularis propria may increase in size over time but this increase cannot be considered as an index of malignancy.
  • [MeSH-major] Endosonography. Gastric Mucosa / ultrasonography. Gastrointestinal Stromal Tumors / ultrasonography. Intestinal Mucosa / ultrasonography. Intestinal Neoplasms / ultrasonography. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Digestive System Surgical Procedures. Disease Progression. Female. Humans. Male. Middle Aged. Prospective Studies. Time Factors. Treatment Refusal

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  • (PMID = 19349904.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Akbulut S, Senol A, Cakabay B, Sezgin A: Giant renal oncocytoma: a case report and review of the literature. J Med Case Rep; 2010;4:52
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  • INTRODUCTION: Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms.
  • Oncocytomas are mostly asymptomatic, and the majority of tumors are discovered incidentally.
  • In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.
  • CASE PRESENTATION: We describe a 25-year-old Turkish woman who was admitted to our hospital with abdominal pain and a 3-year palpable abdominal mass, which was found present since her second pregnancy.

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  • (PMID = 20205900.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827435
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39. Wang RC, Barber AE, Ditmyer M, Vantine P: Distal facial nerve exposure: a key to partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jun;140(6):875-9
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  • 2) Be able to incorporate other modifications of parotidectomy including preservation of the great auricular nerve, superficial musculo-aponeurotic system (SMAS), and parotid duct.
  • STUDY DESIGN: Case series with chart review of partial parotidectomy for benign neoplasms and intraparotid lymph nodes, using antegrade (Group 1) or distal (Group 2) facial nerve exposure, and those conserving the great auricular nerve, SMAS, and parotid duct (Group 3).
  • [MeSH-major] Facial Nerve / anatomy & histology. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19467407.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Marques YM, de Lima Mde D, de Melo Alves Sde M Jr, Soares FA, de Araújo VC, Pinto Ddos S Jr, Mantesso A: Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland. Oral Oncol; 2008 Sep;44(9):903-8
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  • [Title] Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
  • In the absence of p53 mutations, p53 inactivation is possible via complex formation with other proteins, such as Mdm2.
  • The pAkt protein is closely related to Mdm2, and has not been previously reported in salivary gland tumors.
  • Overexpression of Mdm2 and pAkt was present in all the cell lines and tumors studied, whereas the expression of p53 and p21 proteins was considered absent.
  • In conclusion, the signaling pathway in benign salivary gland neoplasm showed an important participation of Mdm2 overexpression protein in tumor formation, progression through inactivation of p53 action, or both, and of pAkt overexpression through increased translocation of Mdm2 protein to cellular nuclei.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-mdm2 / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Cell Line, Tumor. Genes, p53 / genetics. Humans. Immunohistochemistry. Mutation. Signal Transduction / genetics

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  • (PMID = 18485798.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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41. Ardigo M, Zieff J, Scope A, Gill M, Spencer P, Deng L, Marghoob AA: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology; 2007;215(4):354-8
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  • BACKGROUND: Trichoepitheliomas (TE) are benign neoplasms of follicular differentiation.
  • RCM showed oval, darker-appearing tumor islands that contained brightly refractile material, consistent with keratin horn cysts at the center, as well as parallel bundles of highly refractile dermal collagen surrounding the tumor islands.
  • The RCM findings in TE of keratin-filled cysts in tumor islands and attachment of the tumor to follicular structures have not been previously observed in BCC, and thus may also be diagnostically helpful.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy / methods. Head and Neck Neoplasms / pathology. Microscopy, Confocal. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17911996.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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42. Sandoval GA, Levinton C, Blackstien-Hirsch P, Brown AD: Selecting predictors of cancer patients' overall perceptions of the quality of care received. Ann Oncol; 2006 Jan;17(1):151-6
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  • Two main subgroups were analyzed in this study: patients with malignant and benign neoplasms.

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  • (PMID = 16236755.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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43. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54
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  • [Title] Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs.
  • This paper deals with a population-based material collected during the years 1990-1998, and comprises 439 tumours and tumour-like vascular processes from 420 dogs.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • More than one half (242 of 439) occurred in the skin, and a great majority of skin processes (223 of 242) represented benign tumours or tumour-like lesions.
  • The next most common site of summarised lesions was the spleen, with 110 cases, with only 17 processes in this organ being defined as benign.
  • Most tumour-like proliferations were papillary endothelial hyperplasias.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-major] Dog Diseases / pathology. Vascular Neoplasms / veterinary

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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44. Micchelli ST, Vivekanandan P, Boitnott JK, Pawlik TM, Choti MA, Torbenson M: Malignant transformation of hepatic adenomas. Mod Pathol; 2008 Apr;21(4):491-7
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  • Hepatic adenomas are benign neoplasms of the liver that occur in several well-defined clinical settings, but principally that of excess hormone exposure.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Contraceptives, Oral, Hormonal / adverse effects. Female. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / biosynthesis. alpha-Fetoproteins / biosynthesis. beta Catenin / genetics

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  • (PMID = 18246041.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / Tumor Suppressor Protein p53; 0 / alpha-Fetoproteins; 0 / beta Catenin
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45. Goyal P: Advances in endoscopic resection of sinonasal neoplasms. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):277-84
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  • [Title] Advances in endoscopic resection of sinonasal neoplasms.
  • A wide variety of pathology can now be surgically managed with the use of endoscopes both within and beyond the sinonasal tract.
  • Endoscopic techniques allow for excellent visualization and complete tumor resection with low morbidity.
  • As experience continues to grow, endonasal endoscopic techniques are becoming the surgical procedures of choice for the management of a wide variety of benign neoplasms.

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  • (PMID = 23120725.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450232
  • [Keywords] NOTNLM ; Endoscopic surgery / Inverted papilloma / Juvenile nasopharyngeal angiofibroma / Nasal tumors / Sinonasal neoplasms
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46. Carpizo DR, Allen PJ, Brennan MF: Current management of cystic neoplasms of the pancreas. Surgeon; 2008 Oct;6(5):298-307
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  • [Title] Current management of cystic neoplasms of the pancreas.
  • The majority of these cysts represent benign neoplasms; however, a significant fraction of these are pre-malignant or malignant.
  • Because the majority of these neoplasms are benign, many reports have advocated a selective approach to surgical resection.
  • Here we review the literature that has contributed to the development of our approach to the management of these cystic neoplasms.
  • We provide an overview of the key features in diagnosis and in predicting malignancy.
  • Particular attention is given to the natural history and management of intraductal papillary mucinous neoplasms (IPMN).
  • [MeSH-major] Cystadenoma / surgery. Pancreatic Cyst / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Diagnostic Imaging. Humans

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  • (PMID = 18939378.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 51
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47. Thomas L, Uppal HS, Kaur S, David VC: Inflammatory pseudotumour of the maxillary sinus presenting as a sino-nasal malignancy. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):61-3
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  • Inflammatory pseudotumours are a rare group of benign neoplasms of unknown aetiology.
  • A report is made of a 27-year-old female who presented with a rapid-onset proptosis that clinically and radiologically mimicked an aggressive sino-nasal malignancy.
  • [MeSH-major] Granuloma, Plasma Cell / diagnostic imaging. Granuloma, Plasma Cell / pathology. Magnetic Resonance Imaging. Maxillary Sinus Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 14986022.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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48. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • This multicentre study involved 28 Italian ORL Centres responding to a questionnaire sent by us which allowed recruitment of a high large number of cases of parotid neoplasms observed over a 10-year period.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Adenoid-cystic carcinoma was observed in 15.3% and < or = 10% for all the other most frequent histological malignant neoplasms.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • Enucleoresection was limited to approximately 15% of neoplasms, enucleation to <10% of cases with only 2% of pleomorph adenoma due to the well-known anatomo-pathological characteristics which may lead to relapse.
  • For malignant neoplasms, total parotidectomy was performed in approximately 50% of cases, while in the remaining 50% an almost equal rate of superficial parotidectomy was carried out and enlarged parotidectomy, with or without sacrificing the facial nerve, which was rebuilt in 60% of cases.
  • Sentinel lymph node was observed in a limited number of centres.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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49. Cullen KA, Hall MJ, Golosinskiy A: Ambulatory surgery in the United States, 2006. Natl Health Stat Report; 2009 Jan 28;(11):1-25
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  • Females had significantly more ambulatory surgery visits (20.0 million) than males (14.7 million), and a significantly higher rate of visits (132.0 per 1000 population) compared with males (100.4 per 1000 population).
  • The leading diagnoses at ambulatory surgery visits included cataract (3.0 million); benign neoplasms (2.0 million), malignant neoplasms (1.2 million), diseases of the esophagus (1.1 million), and diverticula of the intestine (1.1 million).

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  • (PMID = 19294964.001).
  • [ISSN] 2164-8344
  • [Journal-full-title] National health statistics reports
  • [ISO-abbreviation] Natl Health Stat Report
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Bakker JR, Haber MM, Garcia FU: Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. Am Surg; 2005 Feb;71(2):100-5
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  • [Title] Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction.
  • NF-1 is known to be associated with gastrointestinal neoplasms in 2-25 per cent of patients.
  • We report the first case of gastric outlet obstruction with perforation caused by neurofibroma in a patient with NF-1.
  • The literature is reviewed, examining 61 previously reported cases of noncarcinoid gastrointestinal (GI) neoplasms in patients with NF-1 for symptoms, location, and types of neoplasms.
  • Neoplasms were located most often in the small intestine (72%).
  • Neurofibromas, found in 52 per cent of patients, were the most frequently diagnosed benign neoplasms followed by leiomyomas (13%), ganglioneurofibromas (9.8%), and gastrointestinal stomal tumor (GIST) (6.5%).
  • Patients with NF-1 and GI symptoms are at risk for gastrointestinal neoplasms from which symptomatic patients are likely to experience significant morbidity.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Neurofibromatosis 1 / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Granulation Tissue / pathology. Humans. Male. Peptic Ulcer Perforation / etiology. Peptic Ulcer Perforation / pathology

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  • (PMID = 16022006.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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51. Fleming DM, Cross KW, Barley MA: Recent changes in the prevalence of diseases presenting for health care. Br J Gen Pract; 2005 Aug;55(517):589-95
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  • Age-standardised prevalence rates per 10,000 registered persons and 99% confidence intervals (CIs) were calculated using the national census population for 2001 as the standard.
  • Survey differences in prevalence were identified from non-overlapping CIs.
  • Particular increases were noted for other malignant and benign neoplasms of the skin, hypothyroidism and diabetes.

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  • (PMID = 16105366.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1463227
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52. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C: Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg; 2007 Apr;142(4):347-54
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  • [Title] Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.
  • OBJECTIVE: To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs).
  • Insulinomas were the most common type of functional neoplasm (33.3%), followed by gastrinomas and glucagonomas; 12 patients (7.1%) had multiple endocrine neoplasia type 1.
  • Of the neoplasms, 107 (63.7%) were located in the pancreatic body or tail.
  • We classified 76.8% of neoplasms as benign; of those classified as malignant, 25.6% had liver metastases.
  • Incidentally discovered nonfunctioning neoplasms were significantly more frequent in the last 5 years (60.4% vs 40.3%; P = .007), with a trend toward smaller neoplasms (mean, 4.2 cm vs 5.6 cm; P = .19) and lesser likelihood of malignancy (21.8% vs 40.0%; P = .08).
  • Increasing numbers of PNENs are being resected, largely owing to the incidental detection of nonfunctioning neoplasms.
  • This may lead to the treatment of smaller and less malignant neoplasms.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hospitals, General. Humans. Male. Massachusetts / epidemiology. Middle Aged. Retrospective Studies. Survival Rate / trends. Treatment Outcome

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  • (PMID = 17438169.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK071329; United States / NCI NIH HHS / CA / P01 CA117969
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS519098; NLM/ PMC3979851
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53. Kaza RK, Azar S, Al-Hawary MM, Francis IR: Primary and secondary neoplasms of the spleen. Cancer Imaging; 2010;10:173-82
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  • [Title] Primary and secondary neoplasms of the spleen.
  • With the exception of lymphoma involving the spleen, other primary and secondary neoplasms are rare and infrequently encountered.
  • Primary malignant neoplasms involving the spleen are lymphoma and angiosarcoma.
  • Primary benign neoplasms involving the spleen include hemangioma, lymphangioma, littoral cell angioma and splenic cyst and solid lesions such as hamartoma and inflammatory pseudotumor.
  • [MeSH-major] Diagnostic Imaging. Splenic Diseases / diagnosis
  • [MeSH-minor] Cysts / diagnosis. Granuloma, Plasma Cell / diagnosis. Hamartoma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Lymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology

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  • (PMID = 20713317.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 38
  • [Other-IDs] NLM/ PMC2943678
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54. Paulino AC, Fowler BZ: Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol; 2005 Mar;22(2):89-101
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  • [Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.
  • This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.
  • From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.
  • The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.
  • Twenty-three (5.4%) patients developed a secondary neoplasm.
  • There were 14 malignant neoplasms in 13 (3.0%) and 14 benign neoplasms in 11 patients (2.6%).
  • The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.
  • For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.
  • The 14 second malignant neoplasms (SMN) were osteosarcoma in 3, breast carcinoma in 2, melanoma in 2, malignant fibrous histiocytoma in 1, dermatofibrosarcoma in 1, leiomyosarcoma in 1, mucoepidermoid carcinoma in 1, colon cancer in 1, chronic myelogenous leukemia in 1, and basal cell carcinoma in 1.
  • The 5- and 10-year overall survival rate after diagnosis of an SMN was 69.2%; it was 70% for children with a SMN at the edge or inside the RT field and 66.7% for those outside of the RT field.
  • The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.
  • Only 5 (36%) of the 14 benign tumors occurred in the RT field, with osteochondroma being the most common.
  • More than two-thirds of children with a radiation-induced malignancy are alive 10 years after the diagnosis of a SMN.
  • [MeSH-major] Neoplasms / radiotherapy. Neoplasms, Second Primary / etiology. Radiotherapy / adverse effects


55. Stany MP, Hamilton CA: Benign disorders of the ovary. Obstet Gynecol Clin North Am; 2008 Jun;35(2):271-84, ix
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  • [Title] Benign disorders of the ovary.
  • Most ovarian disorders are benign, with the majority being functional ovarian cysts and benign neoplasms.
  • Imaging can often aid in diagnosis and risk assessment.
  • Benign ovarian disorders are frequently incidental findings, but they may cause symptoms from hormonal overproduction, mass effects, or torsion.
  • Knowledge of the cause, presentation, and natural history of these benign ovarian disorders helps providers counsel and treat patients appropriately.
  • [MeSH-major] Ovarian Cysts. Ovarian Neoplasms. Ovary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 18486841.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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56. Chou JW, Feng CL, Lai HC, Tsai CC, Chen SH, Hsu CH, Cheng KS, Peng CY, Chung PK: Obscure gastrointestinal bleeding caused by small bowel lipoma. Intern Med; 2008;47(18):1601-3
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  • [Title] Obscure gastrointestinal bleeding caused by small bowel lipoma.
  • Obscure gastrointestinal bleeding is a very rare entity which accounts for less than 5% of all gastrointestinal bleeding cases.
  • Small bowel tumors are rare but a serious source of obscure gastrointestinal bleeding.
  • Lipomas are the second most common benign tumors in the small bowel and can produce many complications, including gastrointestinal bleeding.
  • Herein, we describe a case of obscure gastrointestinal bleeding caused by a small bowel tumor which was detected by capsule endoscopy and double-balloon enteroscopy preoperatively.
  • Finally, the tumor was surgically confirmed to be a lipoma.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Ileal Neoplasms / complications. Lipoma / complications
  • [MeSH-minor] Digestive System Surgical Procedures. Humans. Laparoscopy. Male. Middle Aged

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  • (PMID = 18797119.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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57. Restrepo CS, Martinez S, Lemos DF, Washington L, McAdams HP, Vargas D, Lemos JA, Carrillo JA, Diethelm L: Imaging appearances of the sternum and sternoclavicular joints. Radiographics; 2009 May-Jun;29(3):839-59
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  • Pectus excavatum and pectus carinatum are common congenital anomalies that are usually benign but may warrant surgical treatment if they cause compression of vital internal structures.
  • In addition, sternal malignancies (most commonly, metastases and chondrosarcoma) must be distinguished from benign neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Arthritis / radiography. Bone Neoplasms / radiography. Dislocations / radiography. Female. Fractures, Bone / radiography. Funnel Chest / radiography. Humans. Male. Middle Aged. Osteomyelitis / radiography. Postoperative Complications / radiography. Young Adult

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  • (PMID = 19448119.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 88
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58. McGraw TA, Norton SA: Military aeromedical evacuations from central and southwest Asia for ill-defined dermatologic diseases. Arch Dermatol; 2009 Feb;145(2):165-70
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  • Outside the combat zone, these individuals were examined by dermatologists who provided a diagnosis regarded as correct for the purposes of this study.
  • Data from January 1, 2003, through December 31, 2006, were obtained from aeromedical evacuation records and the military's electronic medical records system.
  • PATIENTS: A total of 170 patients evacuated from the combat zone for ill-defined dermatologic diseases, such as skin disorder, not otherwise specified (International Classification of Diseases, Ninth Revision, Clinical Modification code 709.9).
  • MAIN OUTCOME MEASURES: The postevacuation diagnosis assigned, in nearly all cases, by a board-certified dermatologist.
  • RESULTS: Dermatitis, benign melanocytic nevus, malignant neoplasms, benign neoplasms, urticaria, and a group of nonspecific diagnoses were the most common postevacuation diagnoses.

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  • (PMID = 19221261.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Cigna E, Carlesimo B, Bistoni G, Conte F, Palumbo F, Scuderi N: The value of clinical diagnosis of digital glomus tumors. Acta Chir Plast; 2008;50(2):55-8
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  • [Title] The value of clinical diagnosis of digital glomus tumors.
  • Glomus tumors are benign neoplasms that differentiate from the glomus apparatus.
  • This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold.
  • The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and most commonly by ultrasound, with or without Doppler.
  • Surgical resection of the glomus tumor is the definitive treatment with resolution of all symptoms.
  • The nine most recent cases of glomus tumor underwent surgery after clinical assessment alone.
  • In our opinion clinical examination is the most effective method to diagnose this type of tumor and in selected cases it may be sufficient to undergo surgical therapy.
  • [MeSH-major] Angiography / methods. Fingers. Glomus Tumor / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18807392.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
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60. Sigurdardottir JM, Isaksson HJ, Johannsson KB, Jonsson S, Gudbjartsson T: [Histology does not accurately predict the clinical behaviour of bronchopulmonary carcinoids - results from an Icelandic population-based study]. Laeknabladid; 2008 Feb;94(2):125-30
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  • BACKGROUND AND AIMS: Bronchopulmonary carcinoids (BPC) are rare tumors of neuroendocrine origin.
  • These tumors are histologically classified into two distinctive forms, typical and the more malignant atypical BPC.
  • ), accounting for 1.9% of all lung neoplasms in Iceland.
  • Average tumor-diameter was 2.5 cm (range 0.4-5.5), with typical histology in 54 (84%) and atypical in 10 patients (16%).
  • CONCLUSION: BPCs usually behave as benign neoplasms, with excellent long-term survival after surgical removal.
  • Therefore, histology (typical vs. atypical) can not be used with certainty to predict the clinical behaviour of these tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Iceland / epidemiology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Population Surveillance. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18310777.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Iceland
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61. Tei R, Morimoto T, Miyamoto K, Aketa S, Shimokawara T, Shin Y, Hironaka Y: Intradural extramedullary ganglioneuroma associated with multiple hamartoma syndrome. Neurol Med Chir (Tokyo); 2007 Nov;47(11):513-5
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  • She underwent right suboccipital craniectomy and C1-2 hemilaminectomy to remove the tumor.
  • She also suffered from multiple facial trichilemmomas, thyroid goiter, multiple polyposis of the gastrointestinal tract, and pulmonary hamartoma indicating multiple hamartoma syndrome.
  • These benign neoplasms were treated conservatively.
  • [MeSH-major] Ganglioneuroma / pathology. Hamartoma Syndrome, Multiple / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 18037807.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Hakverdi S, Kalaci A, Yaldiz M, Akansu B: Glomus tumor of the hip. An unusual location. Saudi Med J; 2009 Feb;30(2):299-301
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  • [Title] Glomus tumor of the hip. An unusual location.
  • Glomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities.
  • The histopathologic diagnosis was a glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Hip. Soft Tissue Neoplasms / pathology

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  • (PMID = 19198725.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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63. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • Immunohistochemical study showed positivity only for vimentin and factor XIIIa, whereas pan-keratins, actin, desmin, CD34, CD10, and S-100 protein were negative.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • Four tumors involved the skull base; 2 of these underwent preoperative embolization.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The average size of the tumors was 5.8 cm x 2.7 cm with all tumors at least 2.5 cm in greatest dimension by computed tomography or magnetic resonance imaging.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.
  • CONCLUSION: Large vascular neoplasms of the sinonasal cavity, such as hemangiomas and hemangiopericytomas, can be safely removed using endoscopic techniques.
  • [MeSH-major] Endoscopy / methods. Hemangioma / surgery. Hemangiopericytoma / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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65. Melichar B, Solichová D, Freedman RS: Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):240-52
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  • Malignant tumors may contribute to host response that involves both the adaptive and innate immune systems.
  • Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin.
  • In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders.
  • Elevated levels of neopterin have also been observed in the tumor microenvironment.
  • Elevated neopterin has also been connected with depressed function of peripheral blood lymphocytes and a decrease in CD4+ T-cell numbers.
  • [MeSH-major] Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / therapy. Immunotherapy / methods. Neopterin / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / analysis. Endometrial Neoplasms / immunology. Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / immunology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Uterine Cervical Neoplasms / immunology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16445639.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 670-65-5 / Neopterin
  • [Number-of-references] 134
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66. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • PATIENT: A case of a large MPNST is reported, which originated in the left temporalis muscle of a 74-year-old man who did not suffer from von Recklinghausen's disease.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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67. Calbo L, Sciglitano P, Calbo E, Niceta M, Borzì R, Sofia L, Plutino F, Gorgone S: [Carotid body tumor. An often misdiagnosed disease]. G Chir; 2009 Apr;30(4):144-7
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  • [Title] [Carotid body tumor. An often misdiagnosed disease].
  • Chemodectomas are uncommon neoplasms, born by glomic cell of extra-adrenegic system.
  • Usually, these neoplasms are benign and non functioning, but when they are more than 4 cm can induce a neuro-vascular compressive syndrome.
  • In this study the Authors propose the guidelines for diagnostic, clinical and therapeutic management, of these tumors according to their experience.
  • [MeSH-major] Carotid Body Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 19419614.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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68. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Jaw bone metastases: four cases. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Mar;16(1):21-5
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  • OBJECTIVE: Metastatic tumors make up approximately one percent of all oral malignancies.
  • Such tumors may present in the jaw bones and oral soft tissues.
  • The commonest oral site is the mandible.
  • PATIENTS AND METHODS: This is a retrospective study of four cases of metastatic tumors of the jaws seen at the Oral-Maxillofacial Department, General University Hospital of Alexandroupolis, Thrace, Greece from 1989 to 2005, representing 1% of all histologically confirmed malignant tumors at the hospital.
  • The oral symptoms were similar to odontogenic infections or to benign neoplasms.
  • CONCLUSIONS: In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
  • [MeSH-major] Adenocarcinoma / secondary. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology

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  • [RetractionIn] Papadopoulos N. Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):143 [19784531.001]
  • (PMID = 17992450.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Slovenia
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69. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4
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  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • Under a presumptive diagnosis of sialadenitis/sialolithiasis, the patient was administered multiple courses of antibiotics; however, these were not effective.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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70. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • Our current data provide a basis for continued investigation of certain mtDNA variants as predictors of the three adenomatous polyps in a larger number of clinicopathological specimens.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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71. Demonte F, Moore BA, Chang DW: Skull base reconstruction in the pediatric patient. Skull Base; 2007 Feb;17(1):39-51
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  • Tumors of the skull base are rare in children and adolescents and present a complicated management problem for oncologists and surgeons alike.
  • Surgical resection is an integral component of the management of many pediatric neoplasms, especially those that are benign or, though not frankly malignant, are locally invasive.
  • The general principles of skull base reconstruction following tumor ablation are applicable to nearly all patients; the reconstructive algorithm, however, is particularly complex in the pediatric population and the potential benefits of therapy must be balanced against the cumulative impact on craniofacial growth and maturity and the donor site morbidity.
  • A retrospective analysis of all patients less than 19 years of age who underwent resection of a skull base tumor was performed.
  • Data were recorded on patient age, tumor pathology and location, prior therapies, surgical approach, extent of resection, margin status, defect components, details of reconstructive methods employed, complications, additional procedures or interventions, and the use and timing of adjuvant therapies.
  • Complications recorded included partial or total flap loss, cerebrospinal fluid leakage, meningitis, infection, abscess, hematoma or seroma formation, delayed healing, and donor site dysfunction.
  • On the basis of our experience and previous reports in the literature, we offer the following guidelines for the successful multidisciplinary care of children and adolescents undergoing skull base reconstruction after tumor resection:.

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  • (PMID = 17603643.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852573
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72. Brønden LB, Eriksen T, Kristensen AT: Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2010;52:6
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  • [Title] Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • BACKGROUND: The Danish Veterinary Cancer Registry (DVCR) was established in May 2005 to gather information about neoplasms in the Danish dog and cat populations.
  • The objectives of the current study were, with a special focus on mast cell tumours (MCT) to investigate the occurrence, gender distribution, biological behaviour, locations, types, the diagnostic method used and treatment of skin neoplasms in dogs based on information reported to the DVCR.
  • METHODS: From May 15th 2005 through February 29th 2008, reports on a total of 1,768 canine cases of neoplasia in the skin, subcutis or adnexa were submitted.
  • RESULTS: The majority of dogs had a benign neoplasm (66%) while 21% were cases of malignant neoplasia.
  • The most commonly encountered malignant neoplasms were MCT and soft tissue sarcomas and for benign neoplasms, lipomas and histiocytomas were the most common.
  • The location of the neoplasms were primarily in the cutis, subcutis or in the perianal region.
  • The occurrence, gender distribution, biological behaviour and location of canine skin neoplasias in Denmark were similar to earlier reports, although some national variations occurred.
  • CONCLUSIONS: Population based cancer registries like the DVCR are of importance in the collection of non-selected primary information about occurrence and distribution of neoplasms.
  • The DVCR provides detailed information on cases of skin neoplasms in dogs and may serve as a platform for the study of sub-sets of neoplastic diseases (e.g.
  • [MeSH-major] Dog Diseases / epidemiology. Mastocytosis / veterinary. Registries. Skin Neoplasms / veterinary

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  • (PMID = 20096110.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2823750
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73. Ronellenfitsch U, Staiger W, Kähler G, Ströbel P, Schwarzbach M, Hohenberger P: Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach. Diagn Ther Endosc; 2009;2009:286138
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  • [Title] Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach.
  • Background. Surgery remains the only curative treatment for gastrointestinal stromal tumour (GIST).
  • Resection needs to ensure tumour-free margins while lymphadenectomy is not required.
  • Follow-up was performed to obtain information on tumour recurrence.
  • Histology confirmed GIST in 17 cases, 4 tumours were benign neoplasms.

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  • (PMID = 19343179.001).
  • [ISSN] 1070-3608
  • [Journal-full-title] Diagnostic and therapeutic endoscopy
  • [ISO-abbreviation] Diagn Ther Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2662319
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74. Kolb A, Kleeff J, Frohlich B, Werner J, Friess H, Büchler MW: Resection of the intrapancreatic bile duct preserving the pancreas. J Hepatobiliary Pancreat Surg; 2009;16(1):31-4
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  • Benign neoplasms of the distal bile duct are rare, but pose a therapeutic challenge.
  • Here, we present a case of an intrapancreatic benign neuroendocrine tumor that was resected by performing a pancreas-preserving distal bile duct resection.
  • First, a duodenotomy was carried out and a probe was inserted into the pancreatic duct to avoid inadvertent injury.
  • The duodenal incision was closed, and reconstruction was performed by an end-to-side hepaticojejunostomy and a Roux-Y jejunojejunostomy.
  • In conclusion, pancreas-preserving distal bile duct resection might be an option for intrapancreatic benign lesions of the distal bile duct that would otherwise require a partial pancreaticoduodenectomy.
  • [MeSH-major] Carcinoma, Neuroendocrine / surgery. Pancreas / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Bile Ducts / pathology. Cholangiopancreatography, Magnetic Resonance. Digestive System Surgical Procedures. Humans. Male. Middle Aged

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  • (PMID = 19089312.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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75. Okur E, Yildirim I, Bakariş S, Okur N, Kiliç MA: [Pilomatrixoma of the head and neck in six cases]. Kulak Burun Bogaz Ihtis Derg; 2005;14(5-6):121-6
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  • Pilomatrixomas are benign neoplasms of the hair follicle, presenting as a mass in the head and neck region.
  • The lesions were located in the preauricular region in two cases, and in the periorbital region, the forehead, the neck, and in the dorsum of the nose in the other patients, respectively.
  • Histopathologic diagnosis was pilomatrixoma.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Tomography, X-Ray Computed


76. Woo VL, Angiero F, Fantasia JE: Myoepithelioma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 May;99(5):581-9
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  • Soft tissue myoepitheliomas, in contrast to salivary gland myoepitheliomas, are benign neoplasms that typically occur in the soft tissues of the extremities.
  • Both are characterized by a multilobular proliferation of polygonal to fusiform cells embedded in a variably myxoid to chondromyxoid matrix.
  • A histologically similar lesion that has a marked predilection for the anterior dorsum of the tongue has been referred to as ectomesenchymal chondromyxoid tumor.
  • The morphological and immunohistochemical resemblance of soft tissue myoepitheliomas to ectomesenchymal chondromyxoid tumors has led to the use of these designations interchangeably.
  • We present a case of myoepithelioma of the tongue and review the literature, with emphasis on the differential diagnosis and histogenesis of this lesion and pertinent nosologic considerations.
  • [MeSH-major] Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Membrane Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 15829881.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 30
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77. Alberto VO, Kelleher D, Denholm RB, Nutt M, Carney JA: A calcified lung tumour and microcytic anaemia in a young woman: partial expression of the Carney triad. Surgeon; 2008 Aug;6(4):249-51
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  • [Title] A calcified lung tumour and microcytic anaemia in a young woman: partial expression of the Carney triad.
  • The Carney triad is the non-familial addociation of gastric stromal tumours (GISTs), pulmonar chondromas and extra-adrenal paragangliomas.
  • Fewer than 100 cases of the disorder have been reported since its description in 1977.
  • The tumours tend to be multifocal in the affected organ or system.
  • Herein, we describe the case of a 27-year-old woman with multiple gastric GISTs and a pulmonary chondroma, partial expression of the Carney triad.
  • It is important to be aware of the Carney triad when one of its constituent tumours is found, particularly if the patient is a young woman, so that a search can be made for and surveillance instituted for the other components.
  • The lung chondromas are benign neoplasms and ordinarily not symptomatic.
  • If a diagnosis of the tumour can be established by biopsy, surgical resection may not be necessary.
  • [MeSH-major] Anemia / complications. Calcinosis / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Radiography, Thoracic

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  • (PMID = 18697369.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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78. Mann CM, Bramhall SR, Buckels JA, Taniere P: An unusual case of duodenal obstruction-gangliocytic paraganglioma. J Hepatobiliary Pancreat Surg; 2009;16(4):562-5
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  • Gangliocytic paragangliomas are rare tumors located in the gastrointestinal tract that are considered to be benign.
  • They usually present with abdominal pain, and/or gastrointestinal bleeding, and occasionally with obstructive jaundice.
  • We report a case of obstruction in a 17-year-old female, which on histology was found to be a gangliocytic paraganglioma, with an extremely unusual presentation.
  • Intraoperatively, the patient was found to have local tumor extension and regional lymph node invasion, and so she underwent a pylorus-preserving pancreaticoduodenectomy, with local lymph node clearance.
  • [MeSH-major] Duodenal Neoplasms / complications. Intestinal Obstruction / etiology. Paraganglioma / complications
  • [MeSH-minor] Adolescent. Endoscopy, Digestive System. Female. Humans. Lymph Nodes / pathology. Neoplasm Invasiveness. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 19517054.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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79. McGregor D: Hydroquinone: an evaluation of the human risks from its carcinogenic and mutagenic properties. Crit Rev Toxicol; 2007;37(10):887-914
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  • In a study of photographic processors the number of exposed individuals was uncertain and the numbers of cases of individual cancer sites were small.
  • In a motion picture film processing cohort there were significant excess malignancies of the respiratory system among workers engaged in developing, where there was exposure to hydroquinone as well as other chemicals.
  • Hydroquinone has been shown reproducibly to induce benign neoplasms in the kidneys of male F344 rats dosed orally either by gavage (25 and 50 mg/kg body weight) or diet (0.8%).
  • This evaluation showed that all renal tubule adenomas and all cases of renal tubule atypical hyperplasia occurred in areas of severe or end-stage chronic progressive nephropathy and that the neoplasms were not otherwise confined to any particular part of the kidney.
  • They included a mouse bone-marrow cell micronucleus test in which there was no genotoxic activity after exposure to a diet containing 0.8% hydroquinone for 6 days; two (32)P-post-labeling assays, one with targets of Zymbal gland, liver, and spleen in Sprague-Dawley rats, the other with the kidney as target in F344 rats; and the last oral assay was for 8-hydroxydeoxyguanosine adducts in F344 rat kidney DNA.
  • While glutathione conjugates could be responsible for the tumor induction, careful histology seems to show that the most actively toxic of several glutathione compounds tested, 2,3,5-triglutathion-S-yl hydroquinone, targets a very specific region of the kidney, the outer stripe of the outer medulla (OSOM), whereas hydroquinone-associated adenomas are more randomly distributed and occur in the cortex as well as the medulla.
  • A nongenotoxic mode of action that involves exacerbation of a spontaneously occurring rodent renal disease, chronic progressive nephropathy (CPN), is proposed and evaluated.

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  • (PMID = 18027166.001).
  • [ISSN] 1040-8444
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Hydroquinones; 0 / Mutagens; 123-31-9 / hydroquinone
  • [Number-of-references] 169
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80. Venturini E, Magni L, Franchini C, Testa R: Right atrial hemangioma. J Cardiovasc Med (Hagerstown); 2008 Dec;9(12):1260-2
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  • Hemangiomas are rare benign neoplasms of the heart generally diagnosed in young or middle-aged patients.
  • We report a case of asymptomatic 71-year-old-woman in whom the tumor was detected after an echocardiogram.
  • Echocardiography directs the diagnosis toward a cardiac mass but some aspects can suggest the hemangioma; MRI and coronary arteriography establishes the diagnosis showing the typical tumor blush.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangioma / diagnosis

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  • (PMID = 19001934.001).
  • [ISSN] 1558-2027
  • [Journal-full-title] Journal of cardiovascular medicine (Hagerstown, Md.)
  • [ISO-abbreviation] J Cardiovasc Med (Hagerstown)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Das CJ, Dhingra S, Gupta AK, Iyer V, Agarwala S: Imaging of paediatric liver tumours with pathological correlation. Clin Radiol; 2009 Oct;64(10):1015-25
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  • Paediatric hepatic tumours are relatively rare with malignant lesions being twice as frequent as benign neoplasms and are mostly metastases.
  • Differentiating benign from malignant tumours is important as it significantly affects treatment decisions.
  • [MeSH-major] Liver Neoplasms / diagnosis. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / pathology. Adolescent. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Child. Child, Preschool. Contrast Media. Cysts / diagnosis. Cysts / pathology. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / pathology. Hamartoma / diagnosis. Hamartoma / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Hepatoblastoma / diagnosis. Hepatoblastoma / pathology. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / pathology. Sarcoma / diagnosis. Sarcoma / pathology. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19748008.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 45
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82. Chun HJ, Kim ES, Hyun JJ, Kwon YD, Keum B, Kim CD: Gastrointestinal and biliary stents. J Gastroenterol Hepatol; 2010 Feb;25(2):234-43
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  • [Title] Gastrointestinal and biliary stents.
  • Advances in stent design have led to a substantial increase in the use of stents for a variety of malignant and benign strictures in the gastrointestinal tract and biliary system.
  • Covered stents have been introduced to minimize tumor ingrowth through the metal mesh but are associated with higher rates for spontaneous migration.
  • [MeSH-major] Biliary Tract Diseases / surgery. Biliary Tract Surgical Procedures / instrumentation. Digestive System Surgical Procedures / instrumentation. Gastrointestinal Diseases / surgery. Stents

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  • (PMID = 20136988.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 83
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83. Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M: Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2010 May;32(3):215-21
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  • [Title] Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • In one case only there were 2 p53 mutations, one being a c.673-1G>A splice-site mutation in the 3'-end of intron 6 (position--g.15289G>A, contig gb.AY838696.1) and the second being a c.743G>A (p.R248Q) mutation in exon 7 (position--15360G>A, contig gb.AY838696.1).
  • None of the 12 benign control group cases harbored a TP53 mutation, whereas all 12 demonstrated single nucleotide polymorphisms identical to those detected in the malignant tumor group.
  • In conclusion, we found a fairly high rate of p53 expression in malignant neoplasms arising from preexisting benign spiradenomas, cylindromas, and spiradenocylindromas.
  • Whereas immunostaining for p53 has been suggested as an adjunct tool to differentiate benign spiradenoma, cylindroma, and spiradenocylindroma from their malignant counterparts, its utility is limited by its heterogeneous pattern of expression, especially the sometimes lack of staining in clearly malignant areas and the occurrence of focal, weak positivity in the benign residua or in unequivocally benign neoplasms.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Neoplasms, Multiple Primary / genetics. Point Mutation. Sweat Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Syndrome. Young Adult

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  • (PMID = 20075707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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84. Nosrati N, Coleman NM, Hsu S: Axillary syringomas. Dermatol Online J; 2008;14(4):13
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  • Syringomas are common benign neoplasms encountered mostly around the eyes.
  • However, as described herein, these tumors can occur in atypical locations such as the axilla.
  • The differential diagnosis revolves around those entities more likely seen in this anatomical location (such as Fox-Fordyce, Hailey-Hailey and Darier diseases).
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis
  • [MeSH-minor] Adult. Axilla / pathology. Diagnosis, Differential. Female. Humans. Sex Factors. Skin / pathology

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  • (PMID = 18627735.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Xing BC, Sun Y, Bao Q, Qian HG, Hao CY, Huang XF, Wang Y, Gu J, Ji JF: [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]. Zhonghua Yi Xue Za Zhi; 2006 Mar 14;86(10):690-2
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  • [Title] [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm].
  • OBJECTIVE: To investigate the feasibility and safety of spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins in treatment of benign neoplasms of distal pancreas.
  • METHODS: Four patients with solid-pseudopapillary neoplasm, 1 males and 3 females, aged 30 (17 - 37), underwent laparotomy.
  • The distal pancreas with tumor was cut.
  • CONCLUSION: Safe and feasible, spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins is one of the best choices for treatment of benign and borderline tumors of pancreas.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16681929.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Hassounah M, Lach B, Allam A, Al-Khalaf H, Siddiqui Y, Pangue-Cruz N, Al-Omeir A, Al-Ahdal MN, Aboussekhra A: Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol; 2005 May;72(3):203-8
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  • [Title] Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.
  • Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade ependymoma, pilocytic astrocytoma and pituitary adenoma.
  • Using immuno-blot analysis we present evidence that these low-grade tumors are positive for survivin expression.
  • In agreement, flow cytometrical analysis showed that both spontaneous and radiation-induced apoptosis levels are very low in these neoplasms.
  • Using host cell reactivation assay we have also shown that these tumor cells are proficient in the repair of gamma-ray-induced DNA damage.
  • These results suggest that survivin overexpression may be an early event in the stepwise tumoregenesis and hence could be responsible for the onset as well as the growth advantage during tumoregenic progression of malignant as well as benign neoplasms.
  • [MeSH-major] Apoptosis / physiology. Apoptosis / radiation effects. Microtubule-Associated Proteins / biosynthesis. Nervous System Neoplasms / metabolism. Nervous System Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. DNA Damage / radiation effects. Electrophoresis, Polyacrylamide Gel. Flow Cytometry. Gamma Rays. Genes, p53 / genetics. Genes, p53 / radiation effects. Humans. Immunoblotting. Inhibitor of Apoptosis Proteins. Neoplasm Proteins / metabolism. Oncogene Protein p21(ras) / biosynthesis. Oncogene Protein p21(ras) / radiation effects. Tumor Cells, Cultured. Ultraviolet Rays

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  • (PMID = 15937641.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Keter D, Melzer E: Endoscopic ultrasound in clinical practice. Acta Gastroenterol Latinoam; 2008 Jun;38(2):146-51
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  • Endoscopic ultrasonography (EUS) is an accurate technique for the diagnosis and staging of benign and malignant lesions in the gastrointestinal tract and the mediastinum.
  • EUS overcomes the limitations of other imaging diagnostic methods and gives the possibility to obtain tissue for histologic diagnosis (EUS guided FNA).
  • The most useful indications of EUS are differentiation of submucosal tumors, staging for neoplasia, examination of the pancreato-biliary system and therapeutics.
  • EUS is useful for local staging of esophageal, gastric, duodenal, and rectal cancer using the TNM (tumor, node, metastases) system, as well as for diagnosing and staging of pancreatic lesions.
  • EUS is also highly sensitive for the diagnosis of choledocholithiasis, avoiding unnecessary danger of diagnostic ERCP.
  • [MeSH-major] Endosonography / methods. Gastrointestinal Diseases / ultrasonography. Mediastinal Diseases / ultrasonography

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  • (PMID = 18697409.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Argentina
  • [Number-of-references] 32
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88. Ritter MR, Reinisch J, Friedlander SF, Friedlander M: Myeloid cells in infantile hemangioma. Am J Pathol; 2006 Feb;168(2):621-8
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  • Little is known about the pathogenesis of infantile hemangiomas despite the fact that they are relatively common tumors.
  • These benign neoplasms occur in as many as 1 in 10 births, and although rarely life threatening, hemangiomas can pose serious concerns to the cosmetic and psychosocial development of the afflicted child.

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  • (PMID = 16436675.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / F32 EY013916; United States / NEI NIH HHS / EY / R01 EY011254; United States / NEI NIH HHS / EY / F32 EY13916; United States / NEI NIH HHS / EY / R01 EY11254
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / Antigens, CD15; 0 / CD83 antigen; 0 / Immunoglobulins; 0 / Membrane Glycoproteins; 0 / Receptors, IgG
  • [Other-IDs] NLM/ PMC1606494
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89. Bellolio J E, Guzmán G P, Orellana C J, Roa S JC, Villaseca H M, Araya O JC, Tapia E O, Ineda N V: [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms]. Rev Med Chil; 2009 Sep;137(9):1173-8
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  • [Title] [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms].
  • [Transliterated title] Validez diagnóstica de la biopsia intraoperatoria en cirugía de lesiones mamarias palpables.
  • BACKGROUND: During the surgical treatment of breast neoplasms (benign or malignant), frozen section biopsy is frequently requested to assess the kind of lesion and determine the surgical margins.
  • MATERIAL AND METHODS: AH the pathological reports of frozen section biopsies and definitive biopsies of 337 women aged 26 to 88 years, operated for suspected breast neoplasms between 2002 and 2006, were reviewed.
  • The diagnosis of phyllodes tumor was missed by frozen section biopsy in three cases.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Frozen Sections / standards. Intraoperative Care / methods

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  • (PMID = 20011957.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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90. Schmitz-Feuerhake I, Pflugbeil S, Pflugbeil C: [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull]. Gesundheitswesen; 2010 Apr;72(4):246-54
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  • [Title] [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull].
  • [Transliterated title] Röntgenrisiko: Abschätzung der strahleninduzierten Meningeome und anderer Spätschäden bei Exposition des Schädels.
  • A complete assessment of late effects of X-ray diagnostics should take into account that radiation sensitivity varies considerably for the different ages at exposure and, furthermore, that not only malignant diseases but also benign neoplasms are induced which also may lead to severe detriment of the patient.
  • Dose-effect relationships for tumours of the brain, skin, thyroid, and other sites of the head region, leukaemia, and cataracts are taken from the literature.
  • 1,000 annual paediatric CT investigations of the skull will lead to about 3 excess neoplasms in the head region, i.e., the probability of an induced late effect must be suspected in the range of some thousandths.
  • The radiation-induced occurrence of meningiomas and other brain tumours most probably contributes to the continuously increasing incidence of these diseases which is observed in several industrial nations, as well as the exposure of the bone marrow by CT to the increase of childhood leukaemia.
  • [MeSH-major] Brain Neoplasms / etiology. Brain Neoplasms / radiography. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Radiation-Induced / etiology. Skull / radiation effects. Tomography, X-Ray Computed / adverse effects

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19551621.001).
  • [ISSN] 1439-4421
  • [Journal-full-title] Gesundheitswesen (Bundesverband der Ärzte des Öffentlichen Gesundheitsdienstes (Germany))
  • [ISO-abbreviation] Gesundheitswesen
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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91. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Currently, tumors are classified using histologic and immunocytologic characteristics, with diagnostic error rates reported as high as 40% of cases.
  • As a feasibility study, our goal was to generate a preliminary discriminatory gene list for selected mesenchymal tumors, including sarcomas.
  • This technique may enable an eventual molecular classification schema based on expression profiles that can complement current clinical and pathologic diagnostic procedures in mesenchymal tumors.
  • METHODS: cDNA microarray analyses were preformed on connective tissue tumors obtained at time of surgical resection or biopsy.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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92. Cavaliere R, Lopes MB, Schiff D: Low-grade gliomas: an update on pathology and therapy. Lancet Neurol; 2005 Nov;4(11):760-70
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  • Low-grade gliomas (LGG) are not benign neoplasms.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioma / pathology. Glioma / therapy

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  • (PMID = 16239183.001).
  • [ISSN] 1474-4422
  • [Journal-full-title] The Lancet. Neurology
  • [ISO-abbreviation] Lancet Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 119
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93. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • OBJECTIVES: To present our early experience with the transoral approach to the superomedial parapharyngeal space (PPS) and describe our technique for removal of these neoplasms.
  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • RESULTS: The transoral approach described herein safely allowed for en bloc resection of benign neoplasms with intraoperative control and exposure of the internal carotid artery.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This technique is indicated for neoplasms with benign appearance on preoperative imaging or fine needle aspiration.
  • [MeSH-major] Mouth / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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94. Afify A, Zhou H, Howell L, Paulino AF: Diagnostic utility of GLUT-1 expression in the cytologic evaluation of serous fluids. Acta Cytol; 2005 Nov-Dec;49(6):621-6
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  • STUDY DESIGN: Archival paraffin-embedded cell blocks of serous fluids from 25 cases of benign effusions containing reactive mesothelial cells and 39 cases of malignant effusions with metastatic adenocarcinoma (11 ovarian, 11 pulmonary, 9 gastrointestinal and 8 breast) were retrieved from the surgical pathology files.
  • Strong staining in at least 10% of the tumor cells was required in order to consider the case positive for the particular marker.
  • RESULTS: GLUT-1 was expressed in 72% (28 of 39) of cases of malignant effusions: 100% (11 of 11) from the ovary, 91% (10 of 11) from the lung, 67% (6 of 9) from the gastrointestinal tract and 12% (1 of 8) from the breast.
  • None (0 of 25) of the benign effusions expressed GLUT-1.
  • Benign effusions expressed CEA in 3 cases and B72.3 in 2 cases.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ascitic Fluid / pathology. Glucose Transporter Type 1 / biosynthesis. Neoplasms / diagnosis. Pleural Effusion / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / diagnosis. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Cytodiagnosis / methods. Female. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / genetics. Gastrointestinal Neoplasms / pathology. Gene Expression Regulation. Humans. Immunohistochemistry. Lung Neoplasms / diagnosis. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Neoplasms, Mesothelial / diagnosis. Neoplasms, Mesothelial / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology. Pleural Effusion, Malignant / pathology. Sensitivity and Specificity

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  • (PMID = 16450901.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1
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95. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Usunova I, Vladimirov V: [Benign neoplasms of female urethra]. Akush Ginekol (Sofiia); 2009;48(1):31-3
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  • [Title] [Benign neoplasms of female urethra].
  • In clinical practice neoplasms of female urethra are found usually in adult women.
  • Histological sample analysis has provided diagnosis of urethral polyp, caruncle and mucosal prolaps.
  • Collaboration between urologists and gynecologists is essential for early diagnosis, prophylaxis and successful treatment of above mentioned diseases.
  • [MeSH-major] Urethral Neoplasms / diagnosis. Urethral Neoplasms / surgery

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  • (PMID = 19496462.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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97. Uygur-Bayramicli O, Dabak R, Orbay E, Dolapcioglu C, Sargin M, Kilicoglu G, Guleryuzlu Y, Mayadagli A: Type 2 diabetes mellitus and CA 19-9 levels. World J Gastroenterol; 2007 Oct 28;13(40):5357-9
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  • CONCLUSION: CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic, upper gastrointestinal tract, ovarian hepatocellular, and colorectal cancers, as well as in inflammatory conditions of the hepatobiliary system, biliary obstruction and in thyroid diseases.
  • CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.
  • We propose that a higher cut-off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction.
  • [MeSH-major] CA-19-9 Antigen / blood. Diabetes Mellitus, Type 2 / immunology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / immunology


98. Chekrine T, Tawfiq N, Bourhaleb Z, Benchakroun N, Jouhadi H, Sahraoui S, Benider A: [Giant-cell bone tumors of the spine: report of two cases and literature review]. Cancer Radiother; 2009 Sep;13(5):451-4
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  • [Title] [Giant-cell bone tumors of the spine: report of two cases and literature review].
  • [Transliterated title] Deux cas de tumeurs osseuses à cellules géantes du rachis et revue de la littérature.
  • Giant cell tumours (GCT) are relatively rare neoplasms, most often benign.
  • We report two observations of GCT, the spine in a 51-year-old woman and a 14-year-old boy.
  • Computed tomography and magnetic resonance imaging showed osteolysis of the body and vertebral arch of L5 for the first and a process affecting the vertebral body and medullary canal of T6-T7 with spinal cord compression for the second case.
  • The diagnosis was confirmed by histological examination in two cases.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy

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  • (PMID = 19615930.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 15
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99. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Definitive diagnosis was by excision and pathological examination.
  • Pleomorphic adenoma (n=37) were the most common benign neoplasms.
  • The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Submandibular triangle neoplasms are rare and pose many diagnostic and therapeutic challenges.
  • There is a relatively high incidence of malignant neoplasms in this region (54%).
  • Benign tumours manifest a mild course of disease and have an excellent prognosis following adequate excision.
  • Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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100. Capovilla M, Couturier J, Molinié V, Bruneval P, Vieillefond A: [Juxtaglomerular cell tumors: report of two cases with genomic analysis]. Ann Pathol; 2008 Oct;28(5):474-6
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  • [Title] [Juxtaglomerular cell tumors: report of two cases with genomic analysis].
  • [Transliterated title] Tumeur à rénine du rein : à propos de deux cas, avec analyse génomique.
  • Juxtaglomerular-cell tumor (JGCT), first described in 1967, is a rare tumor of the kidney that derives from specialized smooth-muscle cells of the wall of the glomerular afferent arteriole.
  • JGCTs are considered benign, but the clinical follow-up has been short in most reported cases.
  • Only one metastatic case has been reported to date, raising the question of tumors of uncertain malignant potential rather than clearly benign neoplasms.
  • Similarly to the two previously reported cases, these two tumors showed losses on chromosomes 9 and 11, suggesting recurrent chromosomal imbalances.
  • Thus, JGCT might be better considered as a tumor of uncertain malignant potential consequently requiring a prolonged follow-up.
  • [MeSH-major] Juxtaglomerular Apparatus / pathology. Kidney Cortex / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19068398.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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