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1. Kim JH, Choi JW, Seo YS, Lee BJ, Yeon JE, Kim JS, Byun KS, Bak YT, Kim I, Park JJ: Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum. World J Gastroenterol; 2007 Jun 21;13(23):3262-4
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  • [Title] Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum.
  • Benign neoplasia of the duodenum are very rare.
  • The microscopic structure of tubulovillous adenoma has frond-like projection of mucosa with branching papillary structure and generally upward growth into the lumen.
  • We describe a 72-year-old man who showed aduodenal tubulovillous adenoma with unusual inverted cystic growth pattern.
  • Interestingly, this tubulovillous adenomatous lesion was interrupted by gastric metaplasia in the deep portion of the cyst and was closely surrounded by Brunner's glands.
  • Although histogenesis of gastric metaplasia of duodenum is not fully understood, Brunner's glands has been suggested as a precursor for gastric metaplasia.
  • Therefore, these findings argued that this adenoma arises from Brunner's glands through gastric metaplasia.
  • This is the first case of inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum with gastric metaplasia.
  • [MeSH-major] Adenoma / pathology. Brunner Glands / pathology. Cysts / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 17589910.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436617
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2. Lee WA: Gastric extremely well differentiated adenocarcinoma of gastric phenotype: as a gastric counterpart of adenoma malignum of the uterine cervix. World J Surg Oncol; 2005 May 23;3:28
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  • [Title] Gastric extremely well differentiated adenocarcinoma of gastric phenotype: as a gastric counterpart of adenoma malignum of the uterine cervix.
  • BACKGROUND: Most of gastric adenocarcinoma can be simply diagnosed by microscopic examination of biopsy specimen.
  • Rarely the structural and cellular atypia of tumor cells is too insignificant to discriminate from benign foveolar epithelium.
  • CASE PRESENTATION: A 67-year-old male presented with a gastric mass incidentally found on the abdominal computed tomography (CT) for routine medical examination.
  • Gastric endoscopic examination revealed a huge fungating mass at the cardia and mucosal biopsy was performed.
  • The resected stomach revealed a huge fungating tumor at the cardia.
  • Microscopically the tumor was sharply demarcated from surrounding mucosa and composed of very well formed glandular structures without significant cellular atypia, which invaded into the whole layer of the gastric wall.
  • CONCLUSION: The clinicopathologic profiles of gastric extremely well differentiated adenocarcinoma of gastric phenotype include cardiac location, fungating gross type, very similar histology to foveolar epithelial hyperplasia, foveolar mucin phenotype, lack of p53 overexpressoin and high proliferative index.

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  • [Cites] Hum Pathol. 1999 Jul;30(7):826-32 [10414502.001]
  • [Cites] Hum Pathol. 2000 Sep;31(9):1031-5 [11014567.001]
  • [Cites] Am J Surg Pathol. 1989 Sep;13(9):717-29 [2764221.001]
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  • (PMID = 15907218.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1180859
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3. Choi WH, Chung YA, Sohn HS, Park YH, In Shim S: Pleomorphic adenoma mimicking malignant tumor in the parapharyngeal space in a patient with gastric carcinoma. Nucl Med Mol Imaging; 2010 Jun;44(2):143-5

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  • [Title] Pleomorphic adenoma mimicking malignant tumor in the parapharyngeal space in a patient with gastric carcinoma.
  • A 68-year-old man underwent total gastrectomy for stomach cancer.
  • This lesion was pathologically confirmed as pleomorphic adenoma by excision.
  • This case highlights the fact that both benign and malignant lesions in the parotid gland may exhibit intense FDG activity and the need for pathologic confirmation of parotid gland lesions for accurate disease staging.

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  • (PMID = 25013526.001).
  • [ISSN] 1869-3474
  • [Journal-full-title] Nuclear medicine and molecular imaging
  • [ISO-abbreviation] Nucl Med Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC4079776
  • [Keywords] NOTNLM ; FDG-PET / Parapharyngeal space / Pleomorphic adenoma
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4. Park SY, Kim HS, Yoon KW, Cho SB, Lee WS, Park CH, Joo YE, Choi SK, Rew JS: [Prevalence of colorectal adenoma is increased in patients with gastric adenoma]. Korean J Gastroenterol; 2009 Oct;54(4):220-6
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  • [Title] [Prevalence of colorectal adenoma is increased in patients with gastric adenoma].
  • BACKGROUND/AIMS: It has been reported that patients with gastric cancer may be at increased risk of synchronous or metachronous colorectal cancer.
  • However, the incidence of colorectal adenoma in patients with gastric adenoma has not been discussed earlier.
  • The aims of this study were to investigate the incidence of colorectal adenoma and to evaluate the necessity of colonoscopic surveillance in patients with gastric adenoma.
  • METHODS: We performed colonoscopy in 221 patients with gastric adenoma between January 2002 and June 2008.
  • As a control group, 387 consecutive patients without gastric adenoma on gastroscopy who underwent colonoscopy were included.
  • RESULTS: Colorectal adenoma were diagnosed in 57.5% (127/221) of the gastric adenoma group and 38.0% (147/387) of the control group (p<0.001).
  • Univariate analysis demonstrated that gender, age, past history of diabetes, and past history of gastric adenoma were associated with the risk of colorectal adenoma.
  • Multivariate analysis demonstrated that gender (male, aOR 2.31, 95% CI 1.61-3.31), age (> or =50 years, aOR 2.47, 95% CI 1.53-4.01), past history of diabetes (aOR 2.35, 95% CI 1.32-4.20), and presence of gastric adenoma (aOR 1.63, 95% CI 1.13-2.36) appeared to be independent risk factors for colorectal adenoma.
  • CONCLUSIONS: The risk of colorectal adenoma increases significantly in patients with gastric adenoma.
  • We suggest that colonoscopic surveillance may be necessary in patients with gastric adenoma.
  • [MeSH-major] Adenoma / diagnosis. Colorectal Neoplasms / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Age Factors. Aged. Colonoscopy. Diabetes Mellitus / diagnosis. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Sex Factors

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  • (PMID = 19844141.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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5. Tamai N, Kaise M, Nakayoshi T, Katoh M, Sumiyama K, Gohda K, Yamasaki T, Arakawa H, Tajiri H: Clinical and endoscopic characterization of depressed gastric adenoma. Endoscopy; 2006 Apr;38(4):391-4
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  • [Title] Clinical and endoscopic characterization of depressed gastric adenoma.
  • BACKGROUND AND STUDY AIM: Depressed gastric adenoma remains poorly characterized because it is rare, and is infrequently detected by endoscopy.
  • The aim of this study was to elucidate clinical and endoscopic characteristics of depressed adenoma of the stomach.
  • PATIENTS AND METHODS: 95 consecutive patients who underwent endoscopic resection of gastric adenomas were studied.
  • Gastric adenomas, diagnosed according to the Vienna classification, were endoscopically classified into two types: depressed and protruding adenomas.
  • In order to clarify endoscopic features of gastric adenomas, we performed indigo carmine chromoendoscopy as well as magnifying endoscopy with narrow band imaging, which yields clear images of mucosal microvasculature.
  • RESULTS: 12% of 100 gastric adenomas resected from 95 patients were depressed adenomas.
  • [MeSH-major] Adenoma / pathology. Endoscopy, Gastrointestinal / methods. Gastric Mucosa / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16680640.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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6. Kushima R, Vieth M: [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma]. Pathologe; 2010 May;31(3):177-81
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  • [Title] [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma].
  • [Transliterated title] Das tubuläre Magenadenom. Mit Darstellung der Japanischen Kriterien unter Berücksichtigung des "pyloric gland adenoma"
  • The term gastric adenoma usually refers to a flat adenoma of the intestinal type.
  • Adenomas of the gastric type, so-called pyloric gland adenomas (PGA), which was first characterized by German and Japanese pathologists in 1990, have been regarded as exceptional until recently.
  • In this article we introduce the Japanese criteria of the gastric adenoma and review and discuss the clinical pathological and molecular aspects of PGAs.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology

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  • (PMID = 20349063.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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7. Sargan I, Motoc A, Vaida MA, Bolintineanu S: Benign gastric tumors. Anatomopathological aspects of the gastric wall. Rev Med Chir Soc Med Nat Iasi; 2007 Oct-Dec;111(4):996-1000
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  • [Title] Benign gastric tumors. Anatomopathological aspects of the gastric wall.
  • Benign tumours of the stomach are quite rare and are discovered accidentally during routine endoscopy or necroscopy.
  • They represent less than 20 per cent of gastric tumours, and their clinical picture consists in pain, bleeding and antropyloric stenosis.
  • RESULTS: Benign tumoural pathology was present in 73 cases, 43 (58.9%) in women, 30 (42.1%) in men.
  • The material for study consisted in gastric resection pieces and specimens of needle biopsy.
  • In order to establish the histopathological diagnosis and to define the specific type of the damage, the first specimens were stained using morphological methods.
  • [MeSH-major] Biopsy, Needle. Precancerous Conditions / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Aged, 80 and over. Cardia / pathology. Diagnosis, Differential. Female. Hemangioma / pathology. Hospitals, General. Humans. Leiomyoma / pathology. Male. Middle Aged. Neurilemmoma / pathology. Polyps / pathology. Pyloric Antrum / pathology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18389794.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Romania
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8. Sanada Y, Yoshida K: A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes. J Gastrointestin Liver Dis; 2008 Dec;17(4):457-60
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  • [Title] A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes.
  • Here we report a case of benign intraductal papillary-mucinous neoplasm (IPMN) of the pancreas containing two major subtypes.
  • Histopathologic examinations revealed that IPMN was composed of gastric-type adenoma and intestinal-type borderline lesion.
  • Our observations suggest that gastric-type epithelium is a precursor of intestinal-type lesions in the stepwise progression of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Mixed Tumor, Malignant / diagnosis. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] J Gastrointestin Liver Dis. 2009 Jun;18(2):251-2 [19565062.001]
  • (PMID = 19104710.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Mucin-2
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9. Chang HJ, Oh SN, Park MY, Rha SE, Choi BG: Fraudulent retouching of digital radiographic images--a potential risk. Clin Radiol; 2010 Dec;65(12):967-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Ten representative key images were selected of aortic dissection, hepatocellular carcinoma, renal cell carcinoma, colon cancer, liver metastasis, hepatic cyst, gallbladder stones, splenic artery aneurysm, adrenal adenoma, and stomach cancer from abdominal computed tomography (CT) imaging performed in 2008.
  • Radiologists were requested to make a diagnosis for the 10 images, and were then asked to identify possible retouched images.
  • None of the reviewers recognized that some images were retouched during diagnosis.
  • The rate of correct diagnosis was 90% (range 71.7-100%).
  • The time to diagnosis and the time to detection of the retouched images were 15 (14-17) and 6 (5-7) min, respectively.

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  • [Copyright] Copyright © 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21070899.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Tsuchida K, Morinaga S, Sugano N, Shiozawa M, Akaike M, Sugimasa Y, Takemiya S, Hayashi H, Rino Y, Imada T: [A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1878-80
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  • [Title] [A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer].
  • Duodenal adenoma is rare, and there have been very few case reports of flat elevated type adenoma.
  • We report a case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer.
  • A 58-year-old man was referred to our hospital for gastric cancer.
  • Endoscopic examination revealed the gastric cancer and a flat elevated tumor in the descending part of the duodenum, measuring 6 cm in diameter.
  • The biopsy specimen of the duodenal lesion was diagnosed as adenoma.
  • Histologically, the gastric cancer was poorly differentiated adenocarcinoma with submcosal invasion and without lymph node metastasis, and the duodenal tumor was a well differentiated carcinoma in villous adenoma.
  • It is difficult to distinguish a carcinoma from a benign elevated lesion in the duodenum.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Carcinoma / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17212134.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 4
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11. Chetty R, Serra S: Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology; 2009 Sep;55(3):270-6
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  • [Title] Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.
  • AIMS: Intraductal tubular adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body.
  • METHODS AND RESULTS: ITA is composed of tightly packed tubular structures with focal cystic dilation and papillary areas lined by gastric/pyloric epithelium showing minimal to mild cytological atypia.
  • In addition, in the cases in this report and 50% of cases reported in the literature, an associated gastric-type IPMN was present in the same duct as the ITA or in adjacent ducts.
  • The coexistence of ITA and IPMN and the similarities of their epithelial lining (gastric/pyloric mucosa) suggest a possible pathogenic link.
  • CONCLUSIONS: ITA can occur without (type A) or with (type B) an associated gastric-type IPMN.
  • ITA could represent a localized, polypoid form of gastric-type IPMN.It is a benign lesion with no evidence of invasion and no direct tumour-related deaths.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Carcinoma in Situ / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2010 Jun;56(7):968-9; author reply 969 [20636797.001]
  • (PMID = 19723141.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Vallot T: [Gastric polyps]. Presse Med; 2007 Oct;36(10 Pt 2):1412-7
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  • [Title] [Gastric polyps].
  • Gastric polyps exist in a wide variety of types, most often benign.
  • Endoscopic discovery of gastric polyps necessitates biopsies - not only of the lesion but also of the antral and fundic mucosa to determine the therapeutic strategy and subsequent surveillance.
  • These polyps are associated with an elevated frequency of precancerous alterations of the gastric mucosa and consequently by an elevated risk of synchronous or metachronous cancer.
  • Eradication of Helicobacter pylorus may reduce the risk of metachronous gastric cancer and recurrence after resection.
  • The advantages and procedures for endoscopic surveillance of patients with a precancerous condition of the gastric mucosa have not yet been clearly established in populations with a low incidence of cancer.
  • [MeSH-major] Adenocarcinoma. Adenoma. Carcinoid Tumor. Polyps. Precancerous Conditions. Stomach Diseases. Stomach Neoplasms
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Endoscopy. Helicobacter Infections / complications. Helicobacter Infections / prevention & control. Helicobacter pylori. Humans. Incidence. Lymphatic Metastasis. Neoplasm Metastasis. Prevalence. Risk Factors. Stomach / pathology

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  • (PMID = 17482791.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 35
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13. Hughes NR, Goodman ZD, Bhathal PS: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol; 2010 Sep;34(9):1312-8
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  • [Title] An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis.
  • The so-called bile duct adenoma and peribiliary glands are characterized by the expression of two foregut antigens (designated D10 and 1F6) and secretion of acid mucin.
  • On account of this similarity in phenotype and their frequent close association with a large caliber bile duct, it was earlier suggested that bile duct adenoma represent a peribiliary gland hamartoma.
  • Here, we compare the expression of 13 tissue antigens in bile duct adenomas, other benign bile duct lesions, and various foregut-derived tissues, to further investigate the bile duct adenoma phenotype and pathogenesis.
  • Five foregut antigens (D10, 1F6, MUC6, MUC5AC, and TFF2) and secretion of acid mucin were of use in distinguishing bile duct adenoma from other hepatic lesions.
  • Thirty-six bile duct adenomas examined were distinguished by expression of MUC6 (94% of bile duct adenoma), MUC5AC (90%), TFF2 (80%), D10 (67%), and 1F6 (61%), and varying degrees of acid mucin secretion (100%).
  • Of 30 bile duct adenoma tested for all 5 antigens, 40% expressed all 5, 27% expressed 4, 17% expressed 3, 13% expressed 2, and 1 expressed only MUC6.
  • The acini of pyloric gland metaplasia in gallbladder and terminal ileum also stained for D10, 1F6, MUC6, and TFF2, with MUC5AC focally present in the gastric foveolar metaplasia overlying the pyloric gland metaplasia but not in the metaplastic glands.
  • The distinguishing feature of so-called bile duct adenoma is their display of the same phenotype as pyloric gland metaplasia.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunoenzyme Techniques. Intestines / metabolism. Intestines / pathology. Liver / metabolism. Liver / pathology. Male. Middle Aged. Mucins / metabolism. Phenotype. Young Adult

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  • (PMID = 20679879.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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14. Yao K, Iwashita A, Tanabe H, Nishimata N, Nagahama T, Maki S, Takaki Y, Hirai F, Hisabe T, Nishimura T, Matsui T: White opaque substance within superficial elevated gastric neoplasia as visualized by magnification endoscopy with narrow-band imaging: a new optical sign for differentiating between adenoma and carcinoma. Gastrointest Endosc; 2008 Sep;68(3):574-80
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  • [Title] White opaque substance within superficial elevated gastric neoplasia as visualized by magnification endoscopy with narrow-band imaging: a new optical sign for differentiating between adenoma and carcinoma.
  • BACKGROUND: The microvascular pattern (MVP) as visualized by magnification endoscopy (ME) is a reliable marker for differentiating between benign and malignant gastric flat lesions.
  • However, in cases of gastric neoplasia of 0-IIa type, it is sometimes impossible to visualize the MVP because a white opaque substance (WOS) obscures the subepithelial MVP.
  • OBJECTIVE: To investigate whether the morphology of the WOS could be a useful optical sign for discriminating between adenoma and carcinoma.
  • MATERIALS: Forty-six gastric neoplasias of only 0-IIa type (18 adenomas and 28 early carcinomas) were evaluated.
  • INTERVENTION: The prevalence and the morphology of the WOS as visualized by ME with narrow-band imaging (NBI) according to histologic type (adenoma vs carcinoma).
  • RESULTS: In cases in which a neoplasia of 0-IIa type showed either WOS with a regular distribution or a regular MVP, the sensitivity and specificity for discriminating adenoma from carcinoma were 94% and 96%, respectively.
  • CONCLUSION: In cases in which the WOS is observed, rather than assessing the MVP, morphologic analysis of the WOS could be an alternative new optical sign for discriminating adenoma from carcinoma when using ME with NBI.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Gastroscopy / methods. Radiographic Magnification. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Diagnosis, Differential. Female. Gastric Mucosa / blood supply. Gastric Mucosa / pathology. Humans. Image Enhancement / methods. Immunohistochemistry. Male. Microcirculation. Middle Aged. Neoplasm Staging. Probability. Sensitivity and Specificity

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  • [CommentIn] Gastrointest Endosc. 2009 Aug;70(2):402; author reply 402-3 [19631809.001]
  • (PMID = 18656862.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T: Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer; 2006;9(3):177-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
  • Since 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions.
  • The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe.
  • Even under these circumstances, the term "gastric adenoma" usually means flat adenoma of the intestinal type.
  • Gastric-type adenomas have been regarded as exceptional until recently.
  • Although gastric-type adenomas could theoretically be classified into foveolar type and pyloric-gland type, foveolar-type adenoma is, in practice, difficult to distinguish from gastric-foveolar-type adenocarcinoma.
  • In 2003, we first reported systematic clinicopathological analyses of pyloric gland adenoma, demonstrating its unstable and precancerous nature.
  • In this article, we review and discuss the clinicopathological and molecular pathological aspects of gastric-type well-differentiated adenocarcinomas and pyloric gland adenomas, mainly based on our published and unpublished data.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Gastric Mucosa / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Chromosome Aberrations. Humans. Molecular Diagnostic Techniques. Nucleic Acid Hybridization / methods. Stomach / cytology. Stomach / pathology

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  • (PMID = 16952035.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 42
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16. Mazzuco TL, Chabre O, Sturm N, Feige JJ, Thomas M: Ectopic expression of the gastric inhibitory polypeptide receptor gene is a sufficient genetic event to induce benign adrenocortical tumor in a xenotransplantation model. Endocrinology; 2006 Feb;147(2):782-90
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  • [Title] Ectopic expression of the gastric inhibitory polypeptide receptor gene is a sufficient genetic event to induce benign adrenocortical tumor in a xenotransplantation model.
  • To answer it, we genetically engineered primary bovine adrenocortical cells to have them express the gastric inhibitory polypeptide receptor.
  • We observed the formation of an enlarged and hyperproliferative adenomatous adrenocortical tissue that secreted cortisol in a gastric inhibitory polypeptide-dependent manner and induced a mild Cushing's syndrome with hyperglycemia.
  • Thus, a single genetic event, inappropriate expression of a nonmutated GPCR gene, is sufficient to initiate the complete phenotypic alterations that ultimately lead to the formation of a benign adrenocortical tumor.
  • [MeSH-major] Adenoma / genetics. Adrenal Cortex / metabolism. Adrenal Gland Neoplasms / genetics. Cell Transformation, Neoplastic / metabolism. Gene Expression Regulation, Neoplastic. Receptors, Gastrointestinal Hormone / metabolism

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  • (PMID = 16254030.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Gastrointestinal Hormone; 0 / gastric inhibitory polypeptide receptor; 128559-51-3 / RAG-1 protein; WI4X0X7BPJ / Hydrocortisone
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17. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
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  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • All 8 cases had an abrupt transition from benign to high-grade in situ or invasive malignancy.
  • SSA crypts were lined by a variety of gastric-type cells; no cell type predominated.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats

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  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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18. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
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  • [Title] Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases.
  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous adenoma.
  • Pepsinogen II was positive in 5 tumors; thus, the results displayed a pattern of differentiation similar to those of ordinary gastric pyloric or metaplastic pyloric glands.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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19. Abiko K, Baba T, Ogawa M, Mikami Y, Koyama T, Mandai M, Konishi I: Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpus. Pathol Int; 2010 Jan;60(1):42-7
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  • [Title] Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpus.
  • In some areas endometrial glands of adenomyosis were replaced by benign-looking mucinous metaplasia.
  • HIK1083 and MUC6 immunohistochemistry indicated a gastric phenotype of the tumor, as seen in cases of prototypical minimal deviation adenocarcinoma (MDA) of the cervix.

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  • (PMID = 20055951.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers
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20. Kitoh T, Yanai H, Matsubara Y, Nakamura Y, Okamoto T, Hirano A, Yoshida T, Okita K: Endoscopic findings potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy. Hepatogastroenterology; 2005 Mar-Apr;52(62):404-8
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  • [Title] Endoscopic findings potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy.
  • BACKGROUND/AIMS: When a benign-malignant borderline lesion is diagnosed by the usual small gastric biopsy, there is sometimes difficulty in making a clinical decision.
  • To clarify potentially useful findings to predict the existence of gastric cancer in borderline lesions diagnosed by forceps biopsy, we retrospectively analyzed endoscopic features.
  • METHODOLOGY: We diagnosed 68 consecutive gastric benign-malignant borderline lesions (57 cases) by forceps biopsy and endoscopically resected them.
  • The final diagnosis for 24 lesions (35.3%) was adenocarcinoma (adenocarcinoma group), and for 40 lesions (58.8%) was adenoma (adenoma group).
  • RESULTS: We found six endoscopic findings (distal location, reddish surface color, lack of smoothness, lack of glossiness, focal roughness, and focal redness) having statistically significant relationships with adenocarcinoma at the final pathological diagnosis.
  • In multivariate analysis, focal redness (p<0.01) and lack of glossiness (p<0.05) were found to have a significant relationship to gastric cancer.
  • CONCLUSIONS: Endoscopic findings such as focal redness and lack of glossiness were potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Biopsy / methods. Gastroscopy. Stomach Neoplasms / pathology. Surgical Instruments

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  • (PMID = 15816445.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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21. Nio Y, Iguchi C, Itakura M, Toga T, Hashimoto K, Koike M, Omori H, Sato Y, Endo S: High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders. Anticancer Res; 2009 May;29(5):1607-10
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  • [Title] High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders.
  • In the patients with benign and malignant thyroid tumor or tumor-like disorders, the incidence of other malignancies was surveyed, and the frequency of thyroid cancer in patients with breast cancer was also surveyed.
  • PATIENTS AND METHODS: Between 1982 and 2005, a total of 201 female patients received surgery for tumor or tumor-like disorders, including 65 carcinoma, 68 adenoma, 61 adenomatous goiter and 7 chronic thyroiditis cases.
  • RESULTS: The overall incidence rate of breast cancer was 16.4% (33/201) in the patients, who received thyroid surgeries and was much higher than other malignancies: 2.0% gastric cancer, 1.0% uterine and colorectal cancer.
  • The incidence rate of breast cancer in each disease was 13.8% for thyroid cancer, 16.2% for adenoma and 21.3% for adenomatous goiter, but no incidence for chronic thyroiditis.
  • CONCLUSION: It appears that thyroid cancer, adenoma and adenomatous goiter were associated with the risk of breast cancer, but chronic thyroiditis was not related.


22. Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES: [Double strand break of DNA in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2010 Jan;55(1):19-25
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  • [Title] [Double strand break of DNA in gastric adenoma and adenocarcinoma].
  • The aim of this study was to define the differences in expression of 53BP1 and gamma-H2AX, the markers of DSB, among normal, gastric adenoma, and gastric adenocarcinoma tissues.
  • METHODS: Tissue microarray was made with the tissues taken from 121 patients who underwent gastrectomy for gastric adenocarcinoma, and 51 patients who underwent endoscopic mucosal resection for gastric adenoma.
  • The normal tissues were collected from histologically confirmed tissues with no cellular atypia obtained from the patients with gastric adenocarcinoma.
  • RESULTS: In gastric carcinoma cells, 53BP1 and gamma-H2AX were highly expressed as compared to normal epithelial cells and gastric adenoma (p<0.01).
  • There were no differences in the expression of 53BP1 and gamma-H2AX between normal epithelium and gastric adenoma.
  • The expression of 53BP1 in the adenoma with grade II and III atypism was more elevated than in those with grade I atypism.
  • The expression of 53BP1 and gamma-H2AX were not significantly different according to the clinicopathologic parameters in the patients with gastric adenocarcinoma.
  • CONCLUSIONS: The DSB in DNA seems to be associated with the development of gastric adenocarcinoma, but does not affect the premalignant adenoma cells.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. DNA Breaks, Double-Stranded. Stomach Neoplasms / metabolism

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  • (PMID = 20098063.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / H2AFX protein, human; 0 / Histones; 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human; 0 / Tumor Suppressor p53-Binding Protein 1
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23. Jang JS, Lee EJ, Lee SW, Lee JH, Roh MH, Han SY, Choi SR, Jeong JS: [Endoscopic submucosal dissection for early gastric cancer and gastric adenoma]. Korean J Gastroenterol; 2007 Jun;49(6):356-63
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  • [Title] [Endoscopic submucosal dissection for early gastric cancer and gastric adenoma].
  • The aims of this study were to assess the therapeutic efficacy and the safety of ESD in gastric adenoma and in early gastric cancer (EGC).
  • CONCLUSIONS: ESD with IT knife is effective for the treatment of EGC and gastric adenoma even in large or in malignant lesions without definite increased risk of complications.
  • [MeSH-major] Adenoma / surgery. Gastric Mucosa / surgery. Gastroscopy. Stomach Neoplasms / surgery

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  • (PMID = 17641553.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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24. Lee KM, Kim YB, Sin SJ, Jung JY, Hwang JC, Lim SG, Yoo BM, Kim JH, Cho SW: Argon plasma coagulation with submucosal saline injection for gastric adenoma on outpatient basis. Dig Dis Sci; 2009 Dec;54(12):2623-8
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  • [Title] Argon plasma coagulation with submucosal saline injection for gastric adenoma on outpatient basis.
  • Gastric adenoma with low-grade dysplasia (LGD) is a less progressive disease than with high-grade dysplasia; nevertheless, a certain portion of lesions can progress.
  • The purpose of this study was to evaluate the effectiveness of argon plasma coagulation (APC) with submucosa saline injections (APC-SSI) for gastric adenoma with LGD on an outpatient department (OPD) basis.
  • We included 57 patients with 64 lesions of gastric adenoma with LGD.
  • Twelve lesions were adenoma with LGD and two lesions were intramucosal adenocarcinoma.
  • APC-SSI is an effective and safe treatment modality for gastric adenoma with LGD on an OPD basis and it is recommended for patients with risk factors of endoscopic mucosal resection (EMR).
  • After treatment of gastric adenoma, meticulous follow-up endoscopy is recommended for detection of metachronous lesions.
  • [MeSH-major] Adenoma / therapy. Ambulatory Care. Argon Plasma Coagulation. Gastric Mucosa / surgery. Sodium Chloride / administration & dosage. Stomach Neoplasms / therapy

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  • [Copyright] © Springer Science+Business Media, LLC 2008
  • (PMID = 19082886.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride
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25. Zhou JP, Yang ZL, Liu DC, Zhou JP: [Expression of galectin 3 and Sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 May;12(3):297-300
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  • [Title] [Expression of galectin 3 and Sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach].
  • OBJECTIVE: To study the expressive levels of galectin-3(gal-3) and Sambucus nigra agglutinin(SNA) and their clinicopathological significance in the benign and malignant lesions of stomach.
  • METHODS: EnVision immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastatic foci of lymph nodes(n=36), and different types of benign lesions(n=80).
  • RESULTS: The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions(P<0.05, P<0.01).
  • The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells.
  • The positive rates of gal-3 and SNA were significantly lower in histologic grade II(, infiltrating depth T1,T2 and no-metastasis of regional lymph node than those in histologic grade III(,IIII(, infiltrating depth T3,T4 and metastasis of lymph node in gastric cancer(P<0.05).
  • The consistency was found between the expression of gal-3 and SNA in gastric cancer tissues(chi(2)=6.59,P<0.05).
  • CONCLUSIONS: The expressive levels of gal-3 and SNA may be important molecular markers of lectins for reflecting the carcinogenesis, progression and biological behaviors in gastric cancer.
  • [MeSH-major] Galectin 3 / metabolism. Plant Lectins / metabolism. Ribosome Inactivating Proteins / metabolism. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Female. Gastritis / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Polyps / pathology

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  • (PMID = 19434543.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Plant Lectins; 0 / Sambucus nigra lectins; EC 3.2.2.22 / Ribosome Inactivating Proteins
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26. Tsuboi S, Taketa K, Nouso K, Fujikawa T, Manabe K, Ohmori H, Higashi T, Shiratori Y: High level of expression of alpha-fetoprotein receptor in gastric cancers. Tumour Biol; 2006;27(6):283-8
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  • [Title] High level of expression of alpha-fetoprotein receptor in gastric cancers.
  • The expression of the receptor for alpha-fetoprotein (AFP-R) was examined immunohistochemically in 47 cancer and 14 benign human gastric tissues.
  • Thirty-four of the 47 cancer tissues expressed AFP-R showing granular or reticular staining on the cancer cell surface, while only 2 of 61 control cases (14 benign gastric tissues and 47 nonmalignant tissues adjacent to cancer) showed faint and homogeneous staining in the cytoplasm of noncancerous cells.
  • The high level of AFP-R expression in gastric cancers may allow the use of AFP-R as a new clinically useful marker of gastric cancer in the tissue level.
  • [MeSH-major] Receptors, Peptide / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Gastritis / metabolism. Gastritis / pathology. Humans. Immunohistochemistry. Kinetics. Polyps / metabolism. Polyps / pathology. Stomach Ulcer / metabolism. Stomach Ulcer / pathology. alpha-Fetoproteins / metabolism

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 17028464.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Peptide; 0 / alpha-Fetoproteins; 0 / alpha-fetoprotein receptor, human
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27. Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, Lauwers GY: Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol; 2009 Jul;22(7):977-84
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  • [Title] Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study.
  • The diagnosis of gastric epithelial dysplasia, a precursor lesion of gastric adenocarcinoma, is hindered by interobserver variability and by its resemblance to regenerative changes.
  • Loss of cell polarity, a histological feature of gastric epithelial dysplasia, may be difficult to ascertain, especially in the setting of inflammation or injury.
  • A biomarker of cell polarity could be useful in diagnosis of dysplasia, but has not been reported.
  • Two homologs, lgl1 and lgl2, are present in mammals and lgl2 mRNA is highly expressed in the stomach.
  • The goal of our study was to test the hypothesis that Lgl2 protein expression and/or localization are disrupted in gastric epithelial dysplasia and adenocarcinoma.
  • Routinely processed pathology specimens including 94 benign mucosae of digestive organs, in addition to 36 reactive gastropathy, 57 gastric epithelial dysplasia, and 77 gastric adenocarcinomas, were immunostained for Lgl2 protein.
  • All normal, reactive, and chronically inflamed gastric epithelia showed basolateral Lgl2 staining.
  • Normal esophageal, duodenal, colonic, biliary, and pancreatic duct mucosae, as well as gastric intestinal metaplasia, did not express Lgl2.
  • All but one case each of gastric epithelial dysplasia and adenocarcinoma showed either complete loss of anti-Lgl2 immunoreactivity or diffuse, mostly weak, cytoplasmic staining.
  • Our data suggest that Lgl2 expression is either aberrantly localized or lost in gastric epithelial dysplasia and adenocarcinoma, whereas it is maintained in reactive gastric mucosa.
  • We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cytoskeletal Proteins / metabolism. Gastric Mucosa / metabolism. Precancerous Conditions / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Cell Polarity. Female. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Male. Middle Aged. Young Adult

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  • (PMID = 19407852.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Hugl-2 protein, human
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28. Lee SY, Han HS, Lee KY, Hwang TS, Kim JH, Sung IK, Park HS, Jin CJ, Choi KW: Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep; 2007 May;17(5):1051-5
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  • [Title] Sonic hedgehog expression in gastric cancer and gastric adenoma.
  • Here, we analyzed the degree of hedgehog expression in gastric cancer and precancerous tissue.
  • From August 2005 to May 2006, 52 gastric cancers and 16 gastric adenomas were obtained from surgically or endoscopically resected specimens.
  • Although Shh expression was not related to the location, size, metastatic status, or mucin phenotype of the gastric cancer, the expression was stronger in the tubular type of gastric cancer than in the mucinous and signet-ring cell types (p=0.001).
  • Shh expression was stronger in gastric adenoma than in the diffuse-type gastric cancer (p<0.001), but revealed no difference with that of the intestinal-type gastric cancer (p=0.30).
  • Shh expression is related to the intestinal type of gastric cancer.
  • The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis.
  • [MeSH-major] Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 17390043.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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29. Bonanomi G, Mandalà L, Maruzzelli L: Laparoscopic staged adjustable gastric banding and liver resection in morbidly obese patient. Obes Surg; 2010 Aug;20(8):1186-90
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  • [Title] Laparoscopic staged adjustable gastric banding and liver resection in morbidly obese patient.
  • We report the case of a 34-year old morbidly obese female, with a history of polycystic ovarian syndrome and birth control pill therapy, who underwent laparoscopic gastric banding.
  • The intraoperative biopsy was suggestive for a benign lesion of hepatocellular origin but could not make the differential diagnosis between focal nodular hyperplasia and adenoma.
  • The neoplasm had atypical features on postoperative magnetic resonance imaging and was suggestive of liver adenoma.
  • Six months after laparoscopic gastric banding, the patient presented with a weight loss of 24 kg and consented to liver resection.
  • Atypical liver neoplasms are subject to potential degeneration, rupture, and bleeding; therefore, they should be treated surgically to allow final diagnosis and potential cure of the disease.
  • [MeSH-major] Gastroplasty. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery. Obesity, Morbid / surgery

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  • (PMID = 18830783.001).
  • [ISSN] 1708-0428
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Kim JY, Park DY, Kim GH, Choi KU, Lee CH, Huh GY, Sol MY, Song GA, Jeon TY, Kim DH, Sim MS: Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma. Histol Histopathol; 2005 04;20(2):543-9
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  • [Title] Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma.
  • The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases of fresh frozen tissue) using Real-time RT-PCR and immunohistochemistry.
  • Real-time RT-PCR showed that intestinal type gastric adenocarcinomas have higher Smad4 mRNA expression than diffuse type gastric adenocarcinomas.
  • Immunohistochemical stain for Smad4 revealed that expression of Smad4 was significantly lower in diffuse-type gastric adenocarcinoma than intestinal-type gastric adenocarcinomas.
  • Also, higher Smad4 protein expression in intestinal type gastric adenocarcinomas than overall gastric adenoma was noted.
  • The rate of reduced Smad4 expression was higher in advanced gastric cancer than early gastric cancer.
  • These results suggest that Smad4 might play different roles in human gastric carcinogenesis, especially between intestinal type and diffuse type of gastric adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenoma / genetics. Adenoma / metabolism. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism. Trans-Activators / genetics. Trans-Activators / metabolism
  • [MeSH-minor] Adult. Aged. Base Sequence. Female. Gastric Mucosa / metabolism. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Smad4 Protein. Transforming Growth Factor beta / metabolism

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  • (PMID = 15736060.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Transforming Growth Factor beta
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31. Lee SW, Kang SB, Kim YS, Nam SW, Lee DS, Lee HK, Han SW: [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2007 Mar;49(3):152-7
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  • [Title] [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma].
  • BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma.
  • In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%).
  • CONCLUSIONS: c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas.
  • Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Proto-Oncogene Proteins c-met / metabolism. Receptor, ErbB-2 / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 18172343.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, ErbB-2
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32. Lee JH, Byun DS, Lee MG, Ryu BK, Kang MJ, Chae KS, Lee KY, Kim HJ, Park H, Chi SG: Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses. Int J Cancer; 2008 Apr 1;122(7):1573-84
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  • [Title] Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses.
  • To explore the candidacy of hSRBC as a suppressor of gastric tumorigenesis, we analyzed the expression and mutation status of hSRBC in gastric tissues and cell lines. hSRBC transcript was expressed in all normal and benign tumor tissues examined, but undetectable or very low in 73% (11/15) cancer cell lines and 41% (46/111) primary tumors.
  • Our findings suggest that hSRBC is a novel tumor suppressor whose epigenetic inactivation contributes to the malignant progression of gastric tumors, in part, through attenuated p53 response to stresses.
  • [MeSH-major] Gene Silencing. Intracellular Signaling Peptides and Proteins / genetics. Stomach Neoplasms / genetics. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Apoptosis. Blotting, Northern. Cell Line, Tumor. CpG Islands / genetics. DNA Methylation. Down-Regulation. Flow Cytometry. Fluorescent Antibody Technique. Hamartoma / genetics. Humans. Immunoblotting. In Situ Nick-End Labeling. Neoplastic Stem Cells. Polyps / genetics. Promoter Regions, Genetic / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Heterologous

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18059034.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / PRKCDBP protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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33. Gold DV, Stein R, Burton J, Goldenberg DM: Enhanced expression of CD74 in gastrointestinal cancers and benign tissues. Int J Clin Exp Pathol; 2010;4(1):1-12
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  • [Title] Enhanced expression of CD74 in gastrointestinal cancers and benign tissues.
  • Colorectal and gastric carcinomas gave similar results with 60% and 86%, respectively, positive for CD74 with an intense, diffuse staining pattern.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Antigens, Differentiation, B-Lymphocyte / metabolism. Digestive System Neoplasms / metabolism. Histocompatibility Antigens Class II / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Humans. Immunohistochemistry. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Tissue Array Analysis

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  • (PMID = 21228923.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA096924
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation, B-Lymphocyte; 0 / Biomarkers, Tumor; 0 / Histocompatibility Antigens Class II; 0 / invariant chain
  • [Other-IDs] NLM/ PMC3016099
  • [Keywords] NOTNLM ; CD74 / colon carcinoma / gastric carcinoma / invariant chain / pancreatic carcinoma
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34. Jung JT, Lee CH, You SS, Ha HK, Bae JS, Kwon JG, Kim EY, Kim HG, Cho CH, Shin IH: [Grading of histology, expression of apoptosis and cell proliferation in gastric mucosa adjacent to gastric adenoma or adenocarcinoma]. Korean J Gastroenterol; 2005 Oct;46(4):269-75
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  • [Title] [Grading of histology, expression of apoptosis and cell proliferation in gastric mucosa adjacent to gastric adenoma or adenocarcinoma].
  • BACKGROUND/AIMS: Helicobacter pylori (H. pylori) infection can lead to gastric adenoma and carcinoma through atrophic gastritis and intestinal metaplasia.
  • Imbalance between apoptosis and proliferation may play a role in gastric carcinogenesis.
  • We tried to investigate H. pylori infection rate, grade of gastritis, environmental risk factors, expression rate of apoptosis and cell proliferation in mucosa adjacent to tumor, and we also tried to find significant factors associated with gastric carcinogenesis.
  • METHODS: Endoscopically diagnosed twenty cases of intestinal type gastric carcinoma, 20 cases of gastric adenoma, and 40 cases of control (normal or gastritis) were enrolled. H. pylori infection rate, histologic grading, apoptosis and immunohistochemical stain (Ki-67 and p53) to check mucosal proliferation were done in endoscopically biopsied tissues at antrum and body at least 2 cm apart from adenoma or carcinoma.
  • In the multivariate analysis, only atrophy of gland was a significant risk factor for adenoma compared to control group (OR 3.7).
  • CONCLUSIONS: Intestinal metaplasia in antrum and alcohol drinking are significant risk factors for gastric carcinoma.
  • Degree of mucosal proliferation and apoptosis in gastric mucosa adjacent to tumor are not significantly different in three groups.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Apoptosis. Cell Proliferation. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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  • (PMID = 16247270.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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35. Jang JS, Choi SR, Han SY, Roh MH, Lee JH, Lee SW, Jeung JS, Kim MC, Son YK, Baek YH: [Predictive significance of serum IL-6, VEGF, and CRP in gastric adenoma and mucosal carcinoma before endoscopic submucosal dissection]. Korean J Gastroenterol; 2009 Aug;54(2):99-107
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  • [Title] [Predictive significance of serum IL-6, VEGF, and CRP in gastric adenoma and mucosal carcinoma before endoscopic submucosal dissection].
  • BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resected specimen obtained from the same lesion by ESD.
  • METHODS: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers).
  • RESULTS: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05).
  • Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01).
  • CONCLUSIONS: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients.
  • [MeSH-major] Adenoma / diagnosis. C-Reactive Protein / analysis. Carcinoma / diagnosis. Gastric Mucosa / surgery. Interleukin-6 / blood. Stomach Neoplasms / diagnosis. Vascular Endothelial Growth Factors / blood
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Gastroscopy. Humans. Male. Middle Aged. Predictive Value of Tests

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  • (PMID = 19696537.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Interleukin-6; 0 / Vascular Endothelial Growth Factors; 9007-41-4 / C-Reactive Protein
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36. Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS: [Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2005 Jun;45(6):394-400
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  • [Title] [Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma].
  • BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in the gastric adenoma and gastric adenocarcinoma.
  • METHODS: Immunohistochemical staining using monoclonal bcl-2, bcl-xL, bax, p53 antibodies were performed on paraffin embedded specimens from forty-one gastric adenomas and 100 gastric adenocarcinomas.
  • CONCLUSIONS: Bcl-2 protein would be related with the development of gastric adenoma, especially with high grade dysplasia.
  • Bcl-xL and p53 proteins would be involved in the development of relatively early stage of gastric adenocarcinoma but not in tumor progression.
  • Bax protein would be involved in the development of gastric adenocarcinoma and related with depth of invasion, lymph node metastasis, and TNM stage.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Stomach Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism. bcl-2-Associated X Protein / metabolism. bcl-X Protein / metabolism

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  • (PMID = 15973073.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein
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37. Köklü S, Başar O, Akbal E, Ibiş M: Gastric serrated adenoma polyp treated with endoscopic band ligation (with video). Surg Laparosc Endosc Percutan Tech; 2010 Dec;20(6):e204-5
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  • [Title] Gastric serrated adenoma polyp treated with endoscopic band ligation (with video).
  • Serrated adenoma of the stomach has been very rarely reported.
  • A 34-year-old woman underwent upper gastrointestinal endoscopy showing a serrated adenoma polyp at the posterior wall of the junction of the fundus and body of the stomach.
  • At the follow-up, the base of the polyp was free of adenoma.
  • Beside several other polypectomy techniques, the band ligation technique may be used in removing of the gastric polyps, which is cheap, safe and technically easy to perform.
  • [MeSH-major] Adenoma / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Gastric Fundus. Humans. Ligation

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  • (PMID = 21150403.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Video-Audio Media
  • [Publication-country] United States
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38. Cho YE, Kim JY, Kim YW, Park JH, Lee S: Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma. Hum Pathol; 2009 Jul;40(7):975-81
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  • [Title] Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma.
  • We investigated the expression profile of human growth and transformation-dependent protein using immunohistochemistry in gastric tissues including cancer (n = 138), adenoma (n = 37), intestinal metaplasia (n = 20), and normal gastric epithelium (n = 20), then correlated human growth and transformation-dependent protein expression in tumors with clinicopathologic features.
  • Human growth and transformation-dependent protein showed strong staining in the cytoplasm of intestinal-type adenocarcinoma and gastric adenoma, whereas normal gastric antral mucosa showed no staining.
  • Human growth and transformation-dependent protein expression in gastric cancer showed a close association with the Lauren classification, tumor stage, and Ki-67 proliferation index.
  • These findings suggest that human growth and transformation-dependent protein expression is a common occurrence during the progression from a normal gastric mucosa to an intestinal-type carcinoma and may be associated with tumor cell proliferation activity.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Membrane Proteins / biosynthesis. Mitochondrial Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 19269009.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FAM162A protein, human; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Mitochondrial Proteins
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39. Futagami S, Hiratsuka T, Shindo T, Horie A, Hamamoto T, Suzuki K, Kusunoki M, Miyake K, Gudis K, Crowe SE, Tsukui T, Sakamoto C: Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer. Helicobacter; 2008 Jun;13(3):209-18
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  • [Title] Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
  • However, little is known about the localization of APE-1 in Helicobacter pylori-infected gastric mucosa or its role in the development of gastric cancer.
  • To investigate the role of APE-1 in the development of gastric cancer, we examined APE-1 expression and localization in cultured cells and gastric biopsies from patients with H. pylori-infected gastritis or gastric adenoma, and from surgically resected gastric cancer.
  • METHODS: APE-1 mRNA and protein expression were determined in H. pylori (CagA+) water-extract protein (HPWEP)-stimulated MKN-28 cells, gastric adenocarcinoma cell-line (AGS) cells, and human peripheral macrophages by real-time polymerase chain reaction and Western blot analysis.
  • Localization of APE-1 and IkappaBalpha phosphorylation in gastric adenoma and gastric cancer tissues were evaluated by single- and double-label immunohistochemistry.
  • Eradication therapy significantly reduced both APE-1 and 8-OHdG expression levels in the gastric mucosa.
  • APE-1 expression was mainly localized in epithelial cells within gastric adenoma and in mesenchymal cells of gastric cancer tissues.
  • APE-1 expression in gastric cancer tissues was significantly reduced compared to that in H. pylori-infected gastric adenoma, while 8-OHdG index and IkappaBalpha phosphorylation levels did not differ between these two neoplastic tissue types.
  • Co-localization of APE-1 and IkappaBalpha phosphorylation was observed not in gastric cancer cells but in gastric adenoma cells.
  • CONCLUSION: H. pylori infection is associated with increased APE-1 expression in human cell lines and in gastric tissues from subjects with gastritis and gastric adenomas.
  • The observed distinct expression patterns of APE-1 and 8-OHdG in gastric adenoma and gastric cancer tissues may provide insight into the progression of these conditions and warrants further investigation.
  • [MeSH-major] DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism. Gastritis / enzymology. Gastritis / microbiology. Helicobacter Infections / enzymology. Helicobacter pylori. Stomach Neoplasms / enzymology. Stomach Neoplasms / microbiology
  • [MeSH-minor] Adenoma / enzymology. Adenoma / genetics. Adenoma / microbiology. Adult. Aged. Cells, Cultured. Female. Gastric Mucosa / metabolism. Gastric Mucosa / microbiology. Humans. Male. Middle Aged. RNA, Messenger / metabolism

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  • (PMID = 18466396.001).
  • [ISSN] 1523-5378
  • [Journal-full-title] Helicobacter
  • [ISO-abbreviation] Helicobacter
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK061769
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 4.2.99.18 / APEX1 protein, human; EC 4.2.99.18 / DNA-(Apurinic or Apyrimidinic Site) Lyase
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40. Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Tsuneyama K, Takano Y: Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):432-40
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  • [Title] Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings.
  • To clarify the roles of FHIT (fragile histidine triad) and PTEN (phosphatase and tensin homology deleted from human chromosome 10) expression in the genesis and progression of gastric cancers, we examined expression of FHIT and PTEN on tissue microarray containing gastric normal mucosa (n=49), adenoma (n=49), noncancerous mucosa adjacent to carcinoma (n=84) and carcinoma (n=249) by immunohistochemistry.
  • The results showed expression of FHIT and PTEN were lower in gastric carcinoma than those in normal mucosa, noncancerous mucosa adjacent to carcinoma and adenoma of the stomach (P<0.05).
  • FHIT and PTEN expression showed a significantly negative association with depth of invasion, lymphatic invasion, and lymph node metastasis, liver metastasis, and Union Internationale Contre le Cancer staging of gastric carcinoma (P<0.05).
  • Intestinal-type gastric carcinomas highly expressed FHIT and PTEN protein, compared with diffuse-type ones (P<0.05).
  • Expression of FHIT and PTEN were positively related with expression of p53 and cysteine protease protein 32 in gastric carcinoma (P<0.05), as well as favorable prognosis of the patients with the tumors (P<0.05).
  • There was positive relationship between FHIT and PTEN expression in gastric carcinoma (P<0.05).
  • It was suggested that down-regulated expression of FHIT and PTEN contributed to gastric carcinogenesis possibly by involving in the imbalance between apoptosis and proliferation of cells.
  • Their altered expression underlay the molecular basis of invasion, metastasis, differentiation of gastric carcinoma.

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  • (PMID = 18091387.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.6.- / Acid Anhydride Hydrolases
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41. Kwon JH, Choi MG, Lee SW, Shu XX, Bae SH, Choi JY, Yoon SK, Cho YK, Park JM, Lee IS, Kim SW, Chung IS: Trends of Gastrointestinal Diseases at a Single Institution in Korea over the Past Two Decades. Gut Liver; 2009 Dec;3(4):252-8
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  • The most prevalent disease in 1990 was gastric cancer, followed by appendicitis and colorectal cancer.
  • However, by 2006, gastric cancer, colon cancer, and colon adenoma or polyps had become the most prevalent diseases.
  • Although gastric cancer showed a decreasing trend, the rate of colon cancer doubled over two decades.
  • Furthermore, rates of detection and endoscopic treatment of early gastric cancer and adenoma of the stomach and colon have increased noticeably.

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  • (PMID = 20431757.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852723
  • [Keywords] NOTNLM ; Epidemiology / Gastrointestinal diseases / Korea / Trends
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42. Vieth M, Kushima R, de Jonge JP, Borchard F, Oellig F, Stolte M: Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum. Virchows Arch; 2005 May;446(5):542-5

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  • [Title] Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.
  • In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa.
  • The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia.
  • A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC.
  • Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb.
  • The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.
  • [MeSH-major] Adenoma / pathology. Choristoma. Gastric Mucosa. Intestinal Polyps / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Cell Division. Humans. Intestinal Mucosa / pathology. Male. Middle Aged. Mucin 5AC. Mucin-6. Mucins / analysis. Stomach Neoplasms / chemistry. Stomach Neoplasms / pathology

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  • (PMID = 15838648.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins
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43. Tanaka K, Toyoda H, Kadowaki S, Kosaka R, Shiraishi T, Imoto I, Shiku H, Adachi Y: Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy. J Gastroenterol; 2006 Apr;41(4):332-8
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  • [Title] Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy.
  • BACKGROUND: Changes to the mucosal surface of early gastric carcinomas and gastric adenomas as viewed by enhanced-magnification endoscopy with acetic acid have not been investigated thoroughly.
  • Using this technology, we investigated the appearance of the gastric surface patterns of neoplastic and surrounding nonneoplastic mucosa.
  • METHODS: Forty-seven consecutive patients with early gastric carcinomas or gastric adenomas underwent enhanced-magnification endoscopy following 1.5% acetic acid instillation.
  • RESULTS: Surface patterns of gastric tumors and the surrounding mucosa were classified into five types: type I, small round pits of uniform size and shape; type II, slit-like pits; type III, gyrus and villous patterns; type IV, irregular arrangements and sizes of pattern types I, II and III; type V, destructive patterns of types I, II and III.
  • CONCLUSIONS: Enhanced-magnification endoscopy may be useful for identifying gastric tumors and determining the extent of horizontal spread, especially in tumors of the depressed type.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Endoscopy, Gastrointestinal / methods. Image Enhancement. Stomach Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Neoplasm Staging. Prospective Studies. Video Recording

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  • [CommentIn] J Gastroenterol. 2006 Apr;41(4):397-8 [16741625.001]
  • (PMID = 16741612.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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44. Carney JA: Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab; 2009 Oct;94(10):3656-62
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  • BACKGROUND: Two young women, each with paraganglioma and gastric stromal tumor, were encountered in the middle 1970s.
  • One also had an adrenal cortical adenoma and the other pulmonary chondroma.
  • Five additional patients with gastric stromal tumor, paraganglioma, and pulmonary chondroma were found, and all were young women.
  • The gastric lesion was usually the presenting tumor (75%), followed by the lung lesion (15%) and the paraganglionic tumor (10%).
  • Twenty percent of the patients had adrenocortical adenoma(s), and 10% had esophageal leiomyoma(s).
  • The gastric and paraganglionic tumors metastasized in one third and one tenth of the patients, respectively.
  • The pulmonary tumors were asymptomatic and benign.
  • FOLLOW-UP: At follow-up, 80% of the patients were alive, two thirds with pulmonary chondroma, 25% with metastatic or residual gastric stromal tumor, and 5% with primary or metastatic paraganglioma.
  • Twenty percent of the patients were dead, usually from metastatic gastric stromal tumor, less frequently from metastatic paraganglioma.
  • [MeSH-major] Adenoma. Adrenal Cortex Neoplasms. Chondroma. Esophageal Neoplasms. Leiomyoma. Lung Neoplasms. Multiple Endocrine Neoplasia. Neoplastic Syndromes, Hereditary / pathology. Paraganglioma

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  • (PMID = 19723753.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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45. Oh SJ, Lee SJ, Lee HY, Paik YH, Lee DK, Lee KS, Chung JB, Yu JS, Yoon DS: [Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. Korean J Gastroenterol; 2009 Sep;54(3):162-6
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  • Five, six, and two extrapancreatic malignancies had been diagnosed before, during, and after the diagnosis of IPMN.
  • Gastric adenocarcinoma (3 patients, 23%) and colorectal carcinoma (3 patients, 23%) were the most common neoplasms.
  • As benign tumor, there were two gallbladder adenoma, one gastric adenoma, one colonic adenoma and one benign ovarian cystic neoplasm, respectively.
  • CONCLUSIONS: IPMN is associated with high incidence of extrapancreatic tumors, particularly gastric and colorectal neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] Korean J Gastroenterol. 2009 Sep;54(3):196-8 [19844158.001]
  • (PMID = 19844152.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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46. Wu CP, Jiang JT, Tan M, Zhu YB, Ji M, Xu KF, Zhao JM, Zhang GB, Zhang XG: Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol; 2006 Jan 21;12(3):457-9
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  • [Title] Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis.
  • AIM: To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma.
  • METHODS: B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay.
  • Correlation between the expression of B7-H3 and the patients' age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed.
  • RESULTS: B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma.
  • B7-H3 expression in gastric carcinoma samples was not related with the patients' age, sex, lymph node metastasis, and tumor size (P>0.05), but with the survival time, infiltration depth of tumor and tissue type.
  • CONCLUSION: Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Antigens, CD. Antigens, CD80 / metabolism. B7 Antigens. Gastric Mucosa / cytology. Gastric Mucosa / metabolism. Humans. Immunohistochemistry. Prognosis. Receptors, Immunologic. Retrospective Studies. Survival Rate

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  • (PMID = 16489649.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD80; 0 / B7 Antigens; 0 / CD276 protein, human; 0 / Receptors, Immunologic
  • [Other-IDs] NLM/ PMC4066068
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47. Joo MK, Park JJ, Lee WW, Lee BJ, Hwang JK, Kim SH, Jung W, Kim JH, Yeon JE, Kim JS, Byun KS, Bak YT: Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals. Endoscopy; 2010 Feb;42(2):114-20
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  • [Title] Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals.
  • BACKGROUND AND AIMS: We compared the prevalence of adenomatous and cancerous colon polyps in patients who underwent endoscopic removal of gastric neoplasms and in healthy controls.
  • MATERIALS AND METHODS: This retrospective study reviewed the medical records of 186 patients with gastric neoplasms and 186 healthy subjects from January 2002 to October 2008.
  • The gastric neoplasm group was comprised of patients undergoing endoscopic removal of gastric adenomas or early gastric cancers and serial fiberoptic colonoscopy (FCS) for checkups.
  • The control group was comprised of subjects undergoing fiberoptic esophagogastroduodenoscopy (FEGD) and FCS for general checkup and was matched for age and sex with the gastric neoplasm group.
  • The overall prevalence of adenomatous or cancerous polyps ("all polyps") and the prevalence of advanced colonic neoplasms were significantly higher in the gastric neoplasm group than in the control group (all polyps: 40.9 % in the gastric neoplasm group vs. 25.8 % in the control group, P = 0.002; advanced colonic neoplasms: 15.6 % vs. 8.1 %, P = 0.025).
  • The risk factors for all polyps were age, male sex, diabetes mellitus, and being assigned to the gastric neoplasm group, and those for advanced colonic neoplasms were age and being assigned to the gastric neoplasm group.
  • Confining the analysis to the gastric neoplasm group, the risk factors for all polyps were identical with those for the total group; however, those for advanced colonic neoplasm were different (age vs. diabetes and hypertriglyceridemia).
  • CONCLUSION: Endoscopists should consider performing routine FCS in patients undergoing endoscopic removal of gastric neoplasms.
  • [MeSH-major] Adenoma / surgery. Colonic Polyps / epidemiology. Gastrectomy / methods. Gastroscopy / methods. Stomach Neoplasms / surgery

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20140828.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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48. Lee SA, Choi SR, Jang JS, Lee JH, Roh MH, Kim SO, Kim MC, Kim SJ, Jeong JS: Expression of VEGF, EGFR, and IL-6 in gastric adenomas and adenocarcinomas by endoscopic submucosal dissection. Dig Dis Sci; 2010 Jul;55(7):1955-63
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  • [Title] Expression of VEGF, EGFR, and IL-6 in gastric adenomas and adenocarcinomas by endoscopic submucosal dissection.
  • BACKGROUND: The degree of intratumoral microvascular density is thought to affect tumor metastasis and prognosis in various human cancers, including gastric cancer.
  • Despite recent medical advancements, gastric adenoma or adenocarcinoma remains a considerable therapeutic challenge.
  • Endoscopic submucosal dissection (ESD) is a more recent approach that is now commonly used for radical resection of gastric adenoma and adenocarcinoma.
  • AIM AND METHODS: The expression of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and interleukin-6 (IL-6) are related to the prognosis of gastric adenocarcinoma.
  • However, the expression of these factors in gastric adenoma/adenocarcinoma following ESD has not been clearly evaluated.
  • Here, we report on our study of the expression of VEGF, EGFR, and IL-6 by immunohistochemical staining in extracted tissue from adenoma or adenocarcinoma of the stomach by ESD and subsequent evaluation of the correlation of VEGF, EGFR, and IL-6 with other clinicopathological parameters.
  • The patient cohort consisted of 102 patients with adenoma or adenocarcinoma of the stomach.
  • CONCLUSION: The immunohistochemical expression of IL-6 and VEGF can be considered to be useful for clinical diagnosis and follow-up of adenoma or adenocarcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Interleukin-6 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Stomach Neoplasms / pathology. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Needle. Cohort Studies. Female. Gastric Mucosa / pathology. Gastric Mucosa / surgery. Gastroscopy / methods. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sensitivity and Specificity

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  • (PMID = 19757047.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-6; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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49. Takasu N, Kimura W, Moriya T, Takeshita A, Murayama S, Hirai I, Ogata S: A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm. Clin J Gastroenterol; 2010 Aug;3(4):209-13
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  • [Title] A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm.
  • We report a rare case of an intraductal papillary mucinous neoplasm (IPMN) with a pancreatobiliary-type carcinoma in situ (CIS) that originated around a mural nodule formed in a gastric-type adenoma.
  • Histopathologic examination showed an intraductal papillary mucinous carcinoma arising from an adenoma.
  • Hematoxylin and eosin (H&E) staining revealed that most of the tumor components, including the mural nodule, had adenomatous changes, indicating the tumor to be of the gastric type; however, immunohistochemistry showed positive MUC2 expression.

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  • (PMID = 26190249.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Growth pattern / Intraductal papillary mucinous neoplasm / Mural nodule / Subtype
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50. Uchiyama Y, Imazu H, Kakutani H, Hino S, Sumiyama K, Kuramochi A, Tsukinaga S, Matsunaga K, Nakayoshi T, Goda K, Saito S, Kaise M, Kawamuara M, Omar S, Tajiri H: New approach to diagnosing ampullary tumors by magnifying endoscopy combined with a narrow-band imaging system. J Gastroenterol; 2006 May;41(5):483-90
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  • BACKGROUND: A newly developed narrow-band imaging (NBI) system, which uses modified optical filters, can yield clear images of microvessels and surface structure in gastric and colonic diseases.
  • In the present study, we investigated the ability of magnifying endoscopy with NBI (MENBI) to diagnose and differentiate between benign and malignant ampullary tumors.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / pathology. Adenoma / surgery. Aged. Biopsy. Female. Follow-Up Studies. Humans. Inflammation. Male. Microscopy, Video. Middle Aged. Retrospective Studies

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  • (PMID = 16799891.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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51. Lee JM, Lee HW, Hong YS, Kim ES, Park KS, Cho KB, Hwang JS, Kim HS: [A case of acute myocardial infarction occurred immediately after endoscopic submucosal dissection]. Korean J Gastroenterol; 2010 Oct;56(4):249-54
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  • Endoscopic methods such as endoscopic mucosal resection or endoscopic submucosal dissection (ESD) have been increasingly used for the treatment of gastric adenoma and early gastric cancer.
  • [MeSH-major] Dissection / adverse effects. Myocardial Infarction / diagnosis
  • [MeSH-minor] Acute Disease. Adenoma / surgery. Aged. Coronary Angiography. Endoscopy, Gastrointestinal. Female. Gastric Mucosa / surgery. Humans. Stomach Neoplasms / surgery

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  • (PMID = 20962561.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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52. Sun J, Xu K, Wu C, Wang Y, Hu Y, Zhu Y, Chen Y, Shi Q, Yu G, Zhang X: PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies. Tissue Antigens; 2007 Jan;69(1):19-27
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  • [Title] PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies.
  • Then, by using immunohistochemistry staining with monoclonal antibody 2H11, the expression of PD-L1 was found in human gastric carcinoma specimens but not in normal or gastric adenoma tissues.
  • Additional data show that PD-L1 can be regarded as a decisive factor in evaluating gastric carcinoma prognosis and anti-human PD-L1 monoclonal antibody 10E10 could inhibit T-cell apoptosis induced by tumor-associated PD-L1.
  • [MeSH-major] Antibodies, Blocking / physiology. Antibodies, Monoclonal / physiology. Antigens, CD / genetics. Antigens, CD / immunology. Carcinoma / metabolism. Signal Transduction / immunology. Stomach Neoplasms / metabolism

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  • (PMID = 17212704.001).
  • [ISSN] 0001-2815
  • [Journal-full-title] Tissue antigens
  • [ISO-abbreviation] Tissue Antigens
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Blocking; 0 / Antibodies, Monoclonal; 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human
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53. Ogata M, Maejima K, Chihara N, Mizutani S, Komine O, Bo H, Shioya T, Watanabe M, Tokunaga A, Tajiri T: Successful use of endoscopic argon plasma coagulation for patients with early gastric cancer and diabetes mellitus. J Nippon Med Sch; 2007 Jun;74(3):246-50
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  • [Title] Successful use of endoscopic argon plasma coagulation for patients with early gastric cancer and diabetes mellitus.
  • We report on two patients with gastric tumors (early cancer and adema) and diabetes mellitus who were treated with argon plasma coagulation (APC) therapy. Case 1.
  • An early gastric cancer (IIc) in the anterior wall of the gastric antrum was diagnosed on the basis of the results of a gastric endoscopy examination.
  • A 61-year-old man was referred to our hospital because of a gastric tumor.
  • A gastric adenoma in the anterior of the gastric antrum was diagnosed on the basis of the results of a gastric endoscopy examination.
  • Endoscopic APC was performed in both patients to remove the gastric tumors.
  • APC therapy appears to be a safe and useful treatment for patients with diabetes and gastric mucosal lesions.
  • [MeSH-major] Diabetes Complications. Gastroscopy. Laser Coagulation / methods. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / surgery. Aged. Argon. Female. Humans. Male. Middle Aged

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  • (PMID = 17625375.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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54. Tajima Y, Yamazaki K, Makino R, Nishino N, Aoki S, Kato M, Morohara K, Kaetsu T, Kusano M: Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background. Clin Cancer Res; 2006 Nov 1;12(21):6469-79
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  • [Title] Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background.
  • PURPOSE: Gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas, irrespective of their histologic type.
  • In the present study, we determined the clinicopathologic significance of phenotypic marker expression in early-stage gastric differentiated-type tumors and the association between marker expression and genetic alterations.
  • EXPERIMENTAL DESIGN: Phenotypic marker expression was determined by examining the expressions of human gastric mucin (HGM), MUC6, MUC2, and CD10 in 63 gastric adenomas, 133 early differentiated-type carcinomas, and 24 follow-up cases with gastric adenoma.
  • Tumors were classified into gastric, gastric and intestinal mixed, or intestinal phenotypes according to the immunopositivity of the above markers.
  • RESULTS: The expressions of HGM and MUC6, representing gastric or gastric and intestinal mixed phenotypes, were significantly associated with high-grade atypia in the 63 gastric adenomas.
  • A multivariate analysis revealed that gastric adenomas were significantly associated with the intestinal phenotype and were inversely associated with p53 mutation compared with early differentiated-type carcinomas.
  • Malignant transformation from gastric adenoma to carcinoma was shown in 5 of the 24 follow-up cases of gastric adenoma.
  • The malignant transformation was significantly associated with the gastric and intestinal mixed phenotype and was inversely associated with APC mutation.
  • No malignant transformation was found in intestinal phenotype gastric adenomas with APC mutation.
  • CONCLUSIONS: Our present findings show that phenotypic marker expression is associated with tumor aggressiveness during the early stage of gastric differentiated-type tumors.
  • Differences in the biological behavior of tumors with different phenotypes may result from differences in the genetic backgrounds during the incipient phase of gastric tumorigenesis.
  • [MeSH-major] Adenoma / genetics. Adenoma / metabolism. Biomarkers, Tumor / genetics. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism
  • [MeSH-minor] DNA Mutational Analysis. Gastric Mucins / biosynthesis. Genes, APC. Genes, p53. Genes, ras. Humans. Immunohistochemistry. Microsatellite Instability. Microsatellite Repeats. Mucin-2. Mucin-6. Mucins / biosynthesis. Mutation. Neprilysin / biosynthesis. Phenotype. Polymerase Chain Reaction

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  • (PMID = 17085661.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gastric Mucins; 0 / MUC2 protein, human; 0 / MUC6 protein, human; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins; EC 3.4.24.11 / Neprilysin
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55. Noji S, Takayanagi K: A case of laughter therapy that helped improve advanced gastric cancer. Jpn Hosp; 2010 Jul;(29):59-64
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  • [Title] A case of laughter therapy that helped improve advanced gastric cancer.
  • We have reported the case of a patient diagnosed as having advanced gastric cancer at the age of 88 years old.
  • An endoscopy revealed a type-2 gastric cancer of 25 x 30 mm in the lesser curvature of the middle stomach body and an IIa gastric cancer with T2 SS and cardiac accessory lesions.
  • One year and seven months later, an endoscopy of the lesser curvature of the middle stomach body indicated that the lesions clearly improved with a morphological reduction into IIa + IIc masses.
  • A tissue biopsy revealed that nucleus abnormality clearly improved from the initial diagnosis, with no irregularity in size.
  • The suspected lesion was localized to a limited area near the stomach wall.
  • Although partial gastric adenocarcinoma was suspected, the cancers turned into gastric adenoma, atrophic gastritis, and enteroepithelium metaplastic carcinoma.
  • Now, five years after the initial diagnosis, she maintains a good condition.
  • [MeSH-major] Laughter Therapy. Stomach Neoplasms

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  • (PMID = 21706962.001).
  • [ISSN] 0910-1004
  • [Journal-full-title] Japan-hospitals : the journal of the Japan Hospital Association
  • [ISO-abbreviation] Jpn Hosp
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Karam SM, Tomasetto C, Rio MC: Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice. Cell Prolif; 2008 Dec;41(6):923-935
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  • [Title] Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice.
  • OBJECTIVE: It is not known whether or not epithelial progenitors of the pyloric antrum are involved in gastric carcinogenesis.
  • This study was designed to examine the changes that occur in pyloric antral mucous cell lineages and their progenitors during development of gastric adenoma and carcinoma in trefoil factor 1 (TFF1) knockout mice.
  • CONCLUSION: This study shows that the progenitors of pit and gland mucous cells contribute to gastric carcinogenesis in the pyloric antrum of TFF1 knockout mice, strongly supporting the concept of stem cell origin of cancer.
  • [MeSH-major] Epithelial Cells / pathology. Peptides / deficiency. Stem Cells / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aging / pathology. Animals. Cell Differentiation. Cell Division. Cell Lineage. Cell Proliferation. Gastric Mucosa / pathology. Gastric Mucosa / ultrastructure. Lectins / metabolism. Mice. Mice, Inbred C57BL. Mice, Knockout. Neoplasm Invasiveness. Pyloric Antrum / pathology. Pyloric Antrum / ultrastructure. Pylorus / pathology. Pylorus / ultrastructure. Trefoil Factor-1

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  • (PMID = 19040570.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lectins; 0 / Peptides; 0 / Tff1 protein, mouse; 0 / Trefoil Factor-1
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57. Tate G, Suzuki T, Endo Y, Mitsuya T: A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer. Cancer Genet Cytogenet; 2008 Jul;184(1):67-71
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  • In one patient, who suffered from bilateral breast cancer, thyroid adenoma, and gastric malignant lymphoma, we found a single-base substitution in exon 2 (115G>C) of the PTEN gene.
  • [MeSH-minor] Adenoma / complications. Adenoma / genetics. Base Sequence. DNA Primers. Female. Humans. Polymerase Chain Reaction. Thyroid Neoplasms / complications. Thyroid Neoplasms / genetics

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  • (PMID = 18558293.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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58. Haveri H, Westerholm-Ormio M, Lindfors K, Mäki M, Savilahti E, Andersson LC, Heikinheimo M: Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol; 2008;8:9

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  • Both factors were also present in Barrett's esophagus and metaplasia of the stomach.
  • Ihh expression overlapped with that of GATA-6 especially in benign gastrointestinal neoplasias.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Colonic Neoplasms / genetics. GATA4 Transcription Factor / metabolism. GATA6 Transcription Factor / metabolism. Gastric Mucosa / metabolism. Rectal Neoplasms / genetics

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  • (PMID = 18405344.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GATA4 Transcription Factor; 0 / GATA6 Transcription Factor; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2323380
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59. Jeong HK, Park CH, Jun CH, Lee GH, Kim HI, Kim HS, Choi SK, Rew JS: A prospective randomized trial of either famotidine or pantoprazole for the prevention of bleeding after endoscopic submucosal dissection. J Korean Med Sci; 2007 Dec;22(6):1055-9
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  • In a prospective trial, patients undergoing ESD due to gastric adenoma or adenocarcinoma were randomly assigned to pantoprazole or famotidine.
  • [MeSH-major] 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use. Anti-Ulcer Agents / therapeutic use. Famotidine / therapeutic use. Gastric Mucosa / surgery. Gastrointestinal Hemorrhage / prevention & control. Gastroscopy. Postoperative Hemorrhage / prevention & control. Stomach Neoplasms / surgery

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  • [Cites] Endoscopy. 2001 Mar;33(3):221-6 [11293753.001]
  • (PMID = 18162722.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Ulcer Agents; 5QZO15J2Z8 / Famotidine; D8TST4O562 / pantoprazole
  • [Other-IDs] NLM/ PMC2694634
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60. Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Saito Y, Suzuki H, Aiura K, Ogata H, Kumai K, Hibi T: Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia. J Gastroenterol Hepatol; 2010 Apr;25(4):706-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia.
  • BACKGROUND: Autofluorescence (AF) videoendoscopy has an advantage over ordinary videoendoscopy in the diagnosis of gastric neoplasias, and the aim of the present study was to evaluate the effectiveness of using the SAFE-3000 videoendoscopy system to diagnose superficial gastric neoplasias.
  • METHODS: Ordinary videoendoscopy, AF videoendoscopy, and chromoendoscopy (CE) were used to diagnose the tumor existence and extent in 14 patients with gastric adenoma, 40 patients with intestinal-type early gastric cancer (EGC) (10 protruded, and 30 depressed), and nine patients with diffuse-type EGC.
  • RESULTS: For gastric adenomas the diagnostic accuracy between the AF images and white light (WL) images did not differ significantly, and for protruded intestinal-type EGCs and diffuse-type EGCs the diagnostic accuracy did not differ significantly between any of the types of images.
  • The detection rate of pink or orange color in AF images was significantly higher for protruded intestinal-type EGCs than gastric adenomas (P = 0.005), depressed intestinal-type EGCs (P < 0.001), and diffuse-type EGCs (P = 0.027).
  • CONCLUSIONS: Autofluorescence videoendoscopy using the SAFE-3000 system for gastric neoplasias might be useful for diagnosing depressed intestinal-type early gastric cancers.
  • The detection of orange or pink color in AF images may be efficacious in discriminating protruded intestinal-type early gastric cancers from gastric adenomas.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal. Stomach Neoplasms / pathology. Video Recording
  • [MeSH-minor] Aged. Cell Differentiation. Diagnosis, Differential. Equipment Design. Female. Fluorescence. Humans. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 20492326.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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61. Uchida M, Tsukamoto Y, Uchida T, Ishikawa Y, Nagai T, Hijiya N, Nguyen LT, Nakada C, Kuroda A, Okimoto T, Kodama M, Murakami K, Noguchi T, Matsuura K, Tanigawa M, Seto M, Ito H, Fujioka T, Takeuchi I, Moriyama M: Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. J Pathol; 2010 May;221(1):96-105
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  • [Title] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization.
  • Although genomic copy number aberrations (CNAs) of gastric carcinoma at the advanced stage have already been extensively characterized by array comparative genomic hybridization (array CGH) analysis, those of gastric carcinoma in situ (CIS) are still poorly understood.
  • Furthermore, no reports have demonstrated correlations between CNAs and histopathological features of gastric adenoma.
  • In this study, we investigated CNAs of 20 gastric CISs (Vienna category 4.2) and 20 adenomas including seven low-grade adenomas (LGA; Vienna category 3) and 13 high-grade adenomas (HGA; Vienna category 4.1), using oligonucleotide-based array CGH.
  • Since HGA is believed to have a higher risk of progression to invasive carcinoma than LGA, these data suggest that 8q gain is important for the malignant transformation of gastric adenoma.
  • [MeSH-major] Adenoma / genetics. Carcinoma in Situ / genetics. Stomach Neoplasms / genetics

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  • [Copyright] Copyright (c) 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 20217874.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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62. Kim SG, Song HJ, Choi IJ, Cho JY, Jung HY, Keum B, Cheon JH, Lee YC, Kim JG, Park SK, Park BJ, Jung HC, Korean College of Helicobacter and Upper Gastrointestinal Research: A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm. Gut Liver; 2010 Dec;4(4):514-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm.
  • BACKGROUND/AIMS: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm.
  • METHODS: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection.

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  • [Cites] N Engl J Med. 2001 Sep 13;345(11):784-9 [11556297.001]
  • [Cites] J Gastroenterol Hepatol. 2001 Nov;16(11):1211-6 [11903737.001]
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  • [Cites] Aliment Pharmacol Ther. 2006 Sep 1;24(5):837-43 [16918888.001]
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  • (PMID = 21253301.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3021608
  • [Keywords] NOTNLM ; Endoscopic resection / Eradication / Helicobacter pylori / Iatrogenic ulcer / Medical Research Collaboration Center
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63. Inoue K, Fujisawa T, Haruma K: Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies. Int J Biol Markers; 2010 Oct-Dec;25(4):207-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies.
  • The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day.
  • Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A.
  • All four patients with gastric adenoma were in group C.
  • These findings suggest that the "degree of health" of the stomach can be assessed by measuring serum PG and Hp antibodies.
  • [MeSH-major] Adenoma / diagnosis. Antibodies, Bacterial / blood. Helicobacter pylori / immunology. Pepsinogen A / blood. Stomach / pathology. Stomach Neoplasms / diagnosis

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  • (PMID = 21161942.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Biomarkers; 9001-10-9 / Pepsinogen A
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64. Sanada Y, Oue N, Mitani Y, Yoshida K, Nakayama H, Yasui W: Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. J Pathol; 2006 Apr;208(5):633-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype.
  • Gastric cancer (GC) is one of the most common malignancies worldwide.
  • Immunostaining showed that normal gastric mucosa and Paneth cells of the duodenum expressed claudin-18 on cell membranes.
  • Expression of claudin-18 was reduced in several intestinal metaplasias of the stomach.
  • Of 20 samples of gastric adenoma, 18 (90.0%) showed decreased claudin-18 expression.
  • In addition, expression of the gastric and intestinal phenotypes of GC was examined by immunostaining for MUC5AC, MUC6, MUC2, and CD10.
  • Down-regulation of claudin-18 may be involved in GCs with an intestinal phenotype, and may be an early event in gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / biosynthesis. Down-Regulation. Membrane Proteins / biosynthesis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Claudins. Duodenum / metabolism. Gastric Mucosa / metabolism. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Neoplasm Staging. Phenotype. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Analysis. Tumor Cells, Cultured

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  • (PMID = 16435283.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN18 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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65. Kikuchi S, Nemoto Y, Katada N, Sakuramoto S, Kobayashi N, Shimao H, Watanabe M: Results of follow-up endoscopy in patients who underwent proximal gastrectomy with jejunal interposition for gastric cancer. Hepatogastroenterology; 2007 Jan-Feb;54(73):304-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Results of follow-up endoscopy in patients who underwent proximal gastrectomy with jejunal interposition for gastric cancer.
  • BACKGROUND/AIMS: The present study evaluates the findings of long-term follow-up endoscopy in patients who underwent proximal gastrectomy with jejunal interposition for gastric cancer.
  • Tumors of the remnant stomach, early gastric cancer and gastric adenoma, were identified in 2 patients (3.6%) at 24 months and 69 months, respectively.
  • CONCLUSIONS: Jejunal interposition combined with proximal gastrectomy does not always prevent complications related to regurgitation of gastric content, and may not be a suitable treatment in view of postoperative endoscopic surveillance.
  • Further studies are required to identify an appropriate surgical approach to proximal gastrectomy for gastric cancer.
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrectomy / methods. Jejunum / transplantation. Stomach Neoplasms / surgery

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  • (PMID = 17419280.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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66. Yang MH, Son HJ, Lee JH, Kim MH, Kim JY, Kim YH, Chang DK, Rhee PL, Kim JJ, Rhee JC: Do we need colonoscopy in patients with gastric adenomas? The risk of colorectal adenoma in patients with gastric adenomas. Gastrointest Endosc; 2010 Apr;71(4):774-81
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  • [Title] Do we need colonoscopy in patients with gastric adenomas? The risk of colorectal adenoma in patients with gastric adenomas.
  • BACKGROUND: Gastric polyps are found frequently in various colonic polyposis syndromes.
  • Genetic alterations of several genes occur in gastric adenomas and colorectal adenomas.
  • However, it is unknown whether patients with gastric adenomas are at higher risk for colorectal adenomas.
  • OBJECTIVE: To investigate the prevalence rate of colorectal adenoma in patients with gastric adenomas and to determine the association between the presence of gastric adenomas and synchronous colorectal adenomas.
  • PATIENTS: This study involved 87 patients with gastric adenomas and 174 sex-matched and age-matched controls among 19,019 participants who underwent EGD and colonoscopy simultaneously or within 6 months of each other from January 2001 to December 2008 at the Center for Health Promotion of Samsung Medical Center.
  • MAIN OUTCOME MEASUREMENTS: The prevalence rate of colorectal adenoma in patients with gastric adenomas.
  • RESULTS: The 87 gastric adenoma patients included 72 men and 15 women.
  • The prevalence of colorectal adenoma was significantly higher in the gastric adenoma group than in the control group.
  • The majority of colorectal adenomas were located in distal colonic segments in the gastric adenoma group in contrast with proximal colonic segments in the control group.
  • Multivariate logistic regression analysis revealed that independent risk factors for colorectal adenoma were the presence of gastric adenomas (odds ratio [OR], .915; 95% confidence interval [CI], 1.044-3.513) and increasing age over 55 years (OR, 2.943; 95% CI, 1.558-5.560).
  • CONCLUSION: The risk of colorectal adenoma increases significantly in patients with gastric adenomas and in patients over age 55.
  • A screening colonoscopy may be necessary for patients with gastric adenomas to detect colorectal adenomas.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Gastroscopy. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20363417.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Long KB, Srivastava A, Hirsch MS, Hornick JL: PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol; 2010 May;34(5):723-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In total, 190 tumors were evaluated: 156 primary WDNETs (63 PETs, 31 ileal, 5 duodenal, 5 gastric, 19 appendiceal, 13 rectal, and 20 pulmonary carcinoid tumors) and 34 liver metastases (18 PETs and 16 ileal carcinoid tumors).
  • Expression of PAX8 was significantly associated with WHO category 1.1 ("benign" behavior) compared with category 1.2 (uncertain behavior) or 2 (well-differentiated endocrine carcinoma) (positive in 100%, 64%, and 52% of tumors, respectively; P<0.05).
  • PAX8 expression was detected in 0/20 (0%) pulmonary, 1/5 (20%) gastric, 5/5 (100%) duodenal, 0/31 (0%) ileal, 4/19 (21%) appendiceal, and 11/13 (85%) rectal carcinoid tumors.
  • In the GI tract, PAX8 is positive in the majority of duodenal and rectal carcinoid tumors, and in a minor subset of appendiceal and gastric carcinoids.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoid Tumor / pathology. Carcinoma, Islet Cell / secondary. Gastrointestinal Neoplasms / pathology. Lung Neoplasms / pathology. Paired Box Transcription Factors / metabolism. Pancreatic Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Dec;35(12):1906-8 [22067332.001]
  • (PMID = 20414099.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors
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68. Buffart TE, Carvalho B, Mons T, Reis RM, Moutinho C, Silva P, van Grieken NC, Vieth M, Stolte M, van de Velde CJ, Schrock E, Matthaei A, Ylstra B, Carneiro F, Meijer GA: DNA copy number profiles of gastric cancer precursor lesions. BMC Genomics; 2007;8:345
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA copy number profiles of gastric cancer precursor lesions.
  • BACKGROUND: Chromosomal instability (CIN) is the most prevalent type of genomic instability in gastric tumours, but its role in malignant transformation of the gastric mucosa is still obscure.
  • In the present study, we set out to study whether two morphologically distinct categories of gastric cancer precursor lesions, i.e. intestinal-type and pyloric gland adenomas, would carry different patterns of DNA copy number changes, possibly reflecting distinct genetic pathways of gastric carcinogenesis in these two adenoma types.
  • The most frequent aberrations in intestinal-type gastric adenoma were gains on 11q, 9q and 8, and losses on chromosomes 5q, 6, 10 and 13, whereas in pyloric gland gastric adenomas these were gains on chromosome 20 and losses on 5q and 6.
  • However, no significant differences were observed between the two adenoma types.
  • CONCLUSION: The results suggest that gains on chromosomes 8, 9q, 11q and 20, and losses on chromosomes 5q, 6, 10 and 13, likely represent early events in gastric carcinogenesis.
  • [MeSH-major] DNA, Neoplasm / genetics. Precancerous Conditions / genetics. Stomach Neoplasms / genetics

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  • (PMID = 17908304.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2147033
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69. Deng XL, Liu XY, Xu N: Comparative study on low back pain misdiagnosed as spondyloarthropathy. Clin Rheumatol; 2009 Aug;28(8):893-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study aims to investigate features of different diseases with low back pain misdiagnosed as spondyloarthropathy so as to improve the accuracy of diagnosis for spondyloarthropathy.
  • The final diagnoses of these 24 cases were listed below: four malignant tumors (retroperitoneal adipose sarcoma, advanced gastric carcinoma, ovarian papillary epithelioma, acute lymphocytic leukemia), six benign tumors (two parathyroid adenoma with hyperparathyroidism, one intraspinal lipoma, intraspinal ependymomas, sacral tubulocyst, and intraspinal schwannoglioma, respectively).
  • [MeSH-major] Diagnostic Errors. Low Back Pain / etiology. Neoplasms / diagnosis. Severity of Illness Index. Spondylarthropathies / complications. Spondylarthropathies / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. HLA-B27 Antigen / analysis. Humans. Male. Medical Audit. Middle Aged. Pain, Referred / etiology. Young Adult

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  • (PMID = 19449145.001).
  • [ISSN] 1434-9949
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / HLA-B27 Antigen
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70. Gheorghe C, Iacob R, Dumbrava M, Becheanu G, Ionescu M: Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions. Chirurgia (Bucur); 2009 Jan-Feb;104(1):17-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions.
  • We describe for the first time the use of both techniques during the same endoscopic session, in a pilot study, in order to increase the diagnostic yield of histological assessment and provide the staging of the gastric neoplastic lesions thus decreasing the time to therapeutic decision.
  • The indication of CLE/EUS exploration was the presence of a gastric polypoid lesion in 37% of cases, atypical gastric ulcer in 27% of patients, gastric lymphoma 18%, suspicion of gastric cancer recurrence after resection 9% and infiltrating type gastric cancer 9%.
  • Histological assessment after targeted biopsy has established the diagnosis of gastric adenocarcinoma in 55% of cases, gastric lymphoma in 18% of cases, gastric adenoma, gastric GIST and gastric foveolar hyperplasia in 9% of cases respectively.
  • In 2 patients - one case with suspected recurrent gastric cancer after surgery and one case of gastric lymphoma, CLE has indicated normal gastric mucosa.
  • The EUS evaluation showed in one gastric lymphoma patient a lesion interesting the mucosa and submucosa with regional adenopathy and a submucosal lesion with regional adenopathy in the other gastric lymphoma case.
  • [MeSH-major] Endosonography. Microscopy, Confocal. Stomach Neoplasms / pathology. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Gastric Mucosa / pathology. Gastric Mucosa / ultrasonography. Humans. Male. Middle Aged. Neoplasm Staging. Pilot Projects. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 19388564.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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71. Kang HJ, Park DY, Kim KH, Song GA, Lauwers GY: [Pathologic diagnosis of gastric epithelial neoplasia]. Korean J Gastroenterol; 2008 Nov;52(5):273-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pathologic diagnosis of gastric epithelial neoplasia].
  • Gastric epithelial neoplasia is a very common disease entity in Korea, encompassing gastric adenoma and adenocarcinoma.
  • There are still discrepancies in pathologic diagnosis of gastric epithelial neoplasia between Western and Japanese pathologists after Vienna consensus classification.
  • With increasing use of endoscopic therapy such as endoscopic mucosal resection and endoscopic submucosal dissection, it is very important to agree on the consensus criteria in the diagnosis of gastric epithelial neoplasia among pathologists in Korea.
  • On this background, the current concepts, and contemporary issues of definition, diagnostic and classification criteria of gastric epithelial neoplasia were reviewed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Stomach Neoplasms / pathology. Terminology as Topic

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  • (PMID = 19077472.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 25
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72. Ishida M, Egawa S, Aoki T, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Unno M, Moriya T, Horii A, Furukawa T: Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas. Pancreas; 2007 Nov;35(4):348-52
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  • Recently, a consensus nomenclature and criteria were histologically defined for classifying these variants of IPMNs into gastric, intestinal, pancreatobiliary, and oncocytic types.
  • RESULTS: Our series included 27 gastric-, 29 intestinal-, 4 pancreatobiliary-, and 1 oncocytic-type IPMNs.
  • Characteristically, the gastric-type IPMNs were likely to be diagnosed as benign, to be confined to branch ducts, and to have fair prognoses.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18090241.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins
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73. Cho YG, Song JH, Kim CJ, Nam SW, Yoo NJ, Lee JY, Park WS: Genetic and epigenetic analysis of the KLF4 gene in gastric cancer. APMIS; 2007 Jul;115(7):802-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic and epigenetic analysis of the KLF4 gene in gastric cancer.
  • In this study, the molecular basis of the KLF4 inactivation in gastric cancer was investigated by analyzing the somatic mutation, the allelic loss with two microsatellite markers, D9S53 and D9S105, and hypermethylation of the KLF4 gene in 47 gastric adenomas and 81 gastric adenocarcinomas.
  • Mutational analysis revealed one mutation of the KLF4 gene in a diffuse-type advanced gastric adenocarcinoma, but not in the gastric adenoma.
  • An allelic loss was found in 7 (22.6%) of the 31 informative gastric adenoma cases and 15 (31.3%) of the 48 informative cancer cases at one or both markers.
  • In addition, promoter hypermethylation of the KLF4 gene was observed in only two gastric cancers.
  • These results suggest that genetic and epigenetic alterations of the KLF4 gene might play a minor role in gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / genetics. Epigenesis, Genetic. Gene Expression Regulation. Kruppel-Like Transcription Factors / genetics. Stomach Neoplasms / genetics

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  • (PMID = 17614846.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / GKLF protein; 0 / Kruppel-Like Transcription Factors
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74. Xiao L, Wang YC, Li WS, Du Y: The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray. J Exp Clin Cancer Res; 2009;28:152
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  • [Title] The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray.
  • To investigate the role of mTOR signal pathway in the stepwise development of gastric carcinomas, we analyzed the correlations between the mTOR and P70S6K expression and clinic pathological factors and studied its prognostic role in gastric carcinomas.
  • METHODS: mTOR and phospho-p70S6K proteins were examined by immunohistochemistry on tissue microarray containing gastric carcinomas (n = 412), adenomas (n = 47) and non-neoplastic mucosa (NNM, n = 197) with a comparison of their expression with clinicopathological parameters of carcinomas.
  • Cytoplasmic phospho(p)-P706SK was highly expressed in adenoma, compared with ANNMs (p < 0.05), whereas its nuclear expression was lower in gastric carcinomas than gastric adenoma and ANNMs (p < 0.05).
  • These three markers were preferably expressed in the older patients with gastric cancer and intestinal-type carcinoma (p < 0.05).
  • Multivariate analysis showed that age, depth of invasion, lymphatic invasion, lymph node metastasis, Lauren's classification and mTOR expression were independent prognostic factors for overall gastric carcinomas (p < 0.05).
  • CONCLUSION: Aberrant expression of p-P70S6K possibly contributes to pathogenesis, growth, invasion and metastasis of gastric carcinomas.
  • It was considered as a promising marker to indicate the aggressive behaviors and prognosis of gastric carcinomas.
  • [MeSH-major] Intracellular Signaling Peptides and Proteins / metabolism. Protein-Serine-Threonine Kinases / metabolism. Ribosomal Protein S6 Kinases, 70-kDa / metabolism. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology

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  • (PMID = 20003385.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
  • [Other-IDs] NLM/ PMC2797794
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75. Nishio S, Tsuda H, Fujiyoshi N, Ota S, Ushijima K, Sasajima Y, Kasamatsu T, Kamura T, Matsubara O: Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia. Pathol Res Pract; 2009;205(5):331-7
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lobular endocervical glandular hyperplasia (LEGH) is usually assumed to be a benign tumor-like lesion of the glands of the uterine cervix.
  • Gastric mucin was detected with the use of clone HIK1083.
  • Gastric mucin was positive in all 16 LEGH components, as compared with only 6 of the 95 adenocarcinoma components.
  • LEGH may be one of the factors related to the development of cervical adenocarcinoma, but adenocarcinoma with LEGH components does not necessarily develop into a highly aggressive "adenoma malignum. "

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  • (PMID = 19167836.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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76. Rocco A, Caruso R, Toracchio S, Rigoli L, Verginelli F, Catalano T, Neri M, Curia MC, Ottini L, Agnese V, Bazan V, Russo A, Pantuso G, Colucci G, Mariani-Costantini R, Nardone G: Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. Ann Oncol; 2006 Jun;17 Suppl 7:vii103-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression.
  • Gastric adenomas are rare neoplastic growths characterized by localized polypoid proliferations of dysplastic epithelium that tend to progress to infiltrating adenocarcinoma.
  • In this study we investigated, in a series of gastric adenoma specimens from an area at high risk of gastric cancer, the relationship between clinicopathological characteristics of adenoma and Helicobacter pylori infection, APC mutational status, and COX-2 and the down-stream enzyme mPGES1 expression.
  • Pathogenetic mutations of MCR region (codons 1269-1589) of the APC gene were detected only in one case corresponding to a single, small size, low grade, H. pylori-negative adenoma.
  • In conclusion, COX-2 may play a key role in the development and progression of gastric adenoma and could be an attractive target in the management of gastric adenoma at major risk of cancer development.

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  • (PMID = 16760271.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase
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77. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Seven had,enteroenteric intussusceptions from benign neoplasms (two), adhesions (one), local inflammation (one), previous anastomosis (one), Crohn's disease (one), and idiopathic (one).
  • Three had ileocolic disease, including cecal cancer (one), metastatic melanoma (one) and idiopathic (one; whereas five patients had colocolonic intussusception from colon cancer (three), tubulovillous adenoma (one), and local inflammation (one).
  • Of the 15 without intussusception at exploration, five had pathology related to trauma, four had nonincarcerated internal hernia after Roux-en-Y gastric bypass, four had negative explorations, one had adhesions, and one had appendicitis that did not correlate with CT findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Ding XW, Luo HS, Jin X, Yan JJ, Ai YW: Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines. Med Oncol; 2007;24(3):345-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines.
  • The aim of this study is to investigate expression of Eag1 potassium channel in gastric cancer and its role in cancer cells growth.
  • The expression of Eag1 for gasric cancer patients and cell lines as well as gastric adenoma was investigated by immunohistochemistry and reverse transcription polymerase chain reaction.
  • Frequency of positive expression of Eag1 protein was 70.5% (67/95) and Eag1 mRNA was 68.2% (15/22) in gastric cancer primary tissues.
  • Eag1 mRNA was positively expressed in two gastric cell lines.
  • Eag1 protein and mRNA were negatively expressed in paired non-cancerous matched tissues and 5 cases of adenoma tissues.
  • The study indicates Eag1 is aberrantly expressed in gastric cancer tissues and cell lines and associated with cancer lymph node metastasis and stage and play an important role in the proliferation of gastric cancer cells.
  • [MeSH-major] Adenoma / metabolism. Ether-A-Go-Go Potassium Channels / metabolism. Gene Expression Regulation, Neoplastic. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Cell Line, Tumor. Cell Proliferation. Chi-Square Distribution. Female. Humans. Immunohistochemistry. Lymphatic Metastasis / diagnosis. Male. Matched-Pair Analysis. Middle Aged. Neoplasm Metastasis / physiopathology. RNA, Messenger / analysis. Reference Values

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  • (PMID = 17873312.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ether-A-Go-Go Potassium Channels; 0 / KCNH1 protein, human; 0 / RNA, Messenger
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79. Carmack SW, Genta RM, Graham DY, Lauwers GY: Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol; 2009 Jun;6(6):331-41
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  • [Title] Management of gastric polyps: a pathology-based guide for gastroenterologists.
  • 1-4% of patients who undergo gastric biopsy have gastric polyps.
  • Hyperplastic polyps, which arise in patients with underlying gastritis, and fundic-gland polyps, which are associated with PPI therapy, are the most common gastric polyps; however, prevalence varies widely relative to the local prevalence of Helicobacter pylori infection and use of PPI therapy.
  • Approximately 20% of biopsy specimens identified endoscopically as polyps have no definite pathological diagnosis.
  • Evaluation of the phenotype of the gastric mucosa that surrounds a lesion will provide significant information crucial to the evaluation, diagnosis and management of a patient.
  • The presence of a gastric adenoma should prompt the search for a coexistent carcinoma.
  • The endoscopic characteristics, histopathology, pathogenesis, and management recommendations of polyps and common polypoid lesions in the stomach are discussed in this Review.
  • [MeSH-major] Adenoma / pathology. Adenoma / therapy. Polyps / pathology. Polyps / therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / therapy
  • [MeSH-minor] Biopsy. Education, Medical, Continuing. Gastritis / epidemiology. Gastritis / pathology. Gastritis / therapy. Gastroenterology. Helicobacter Infections / epidemiology. Helicobacter Infections / pathology. Helicobacter Infections / therapy. Humans. Stomach / pathology

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  • (PMID = 19421245.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 84
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80. Vieth M, Stolte M: Elevated risk for gastric adenocarcinoma can be predicted from histomorphology. World J Gastroenterol; 2006 Oct 14;12(38):6109-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elevated risk for gastric adenocarcinoma can be predicted from histomorphology.
  • The number of patients with gastric cancer has more than doubled since 1985 in developing countries.
  • Thus, the questions of whether it can be predicted from gastritis morphology, who is at risk and who has a lower risk of developing gastric carcinoma are raised.
  • The frequency of ulcerations among H pylori-infected individuals is estimated to be 13%, gastric cancer about 1% and MALT lymphoma around 0.1%.
  • Differences in topography, grade and activity of Helicobacter gastritis in the antrum and corpus might be good markers for identifying those who are at risk of developing gastric cancer.
  • It is known that the so-called corpus dominant H pylori gastritis is found more frequently among individuals with early and advanced gastric cancer and within high risk populations.
  • This is valid both for first-degree relatives of gastric cancer patients and for patients with gastric adenoma and hyperplastic polyps.
  • In conclusion, corpus-dominant H pylori gastritis is significantly more common in patients with advanced and early gastric cancer, first-degree relatives of patients with gastric cancer, patients with gastric adenoma and gastric hyperplastic polyps.
  • Therefore, all these patients are at risk of developing gastric cancer.
  • It appears that patients with a low acid output more frequently develop gastric cancer.
  • Large prospective long term studies are necessary to prove this and identify new reliable markers for gastric cancer development.
  • [MeSH-major] Adenocarcinoma / etiology. Gastritis / pathology. Stomach / pathology. Stomach Neoplasms / etiology

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  • (PMID = 17036380.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 47
  • [Other-IDs] NLM/ PMC4088102
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81. Gutiérrez-Grobe Y, Gavilanes-Espinar JG, Uribe M, Kobashi-Margáin RA, Méndez-Sánchez N: Pyloric gland adenoma: case report. Rev Gastroenterol Mex; 2010;75(3):360-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pyloric gland adenoma: case report.
  • Pyloric gland adenoma (PGA), also called adenoma with gastric differentiation, is a rare neoplasm of the gastric mucosa that can appear as gastric heterotopia in several organs.
  • A 49-year-old woman presented with gastric reflux and chronic elevation of liver enzymes.
  • A few polyps were found and resected from the gastric fundus; histopathology revealed a pyloric gland adenoma.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20959193.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6
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82. Lee SH, Cheon JH, Kim JH, Park JP, Lee SK, Lee YC: [Non-healing iatrogenic gastric ulcers after endoscopic mucosal resection for gastric epithelial neoplasia: report of two cases]. Korean J Gastroenterol; 2008 Feb;51(2):127-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Non-healing iatrogenic gastric ulcers after endoscopic mucosal resection for gastric epithelial neoplasia: report of two cases].
  • Endoscopic mucosal resection (EMR) is widely accepted as a standard treatment for early gastric cancer or gastric adenoma.
  • Although the characteristics of EMR-induced ulceration are not fully understood, this type of ulcer is thought to heal faster and to recur less often than non-iatrogenic gastric ulcer.
  • Herein, we report two cases of non-healing persistent gastric ulcers after EMR.
  • One is a case of gastric carcinoma which developed at the same site of previous EMR site for the low grade dysplasia.
  • [MeSH-major] Gastric Mucosa / surgery. Stomach Neoplasms / surgery. Stomach Ulcer / etiology

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  • (PMID = 18349575.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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83. Kuroki T, Tajima Y, Tsutsumi R, Tsuneoka N, Kitasato A, Adachi T, Kanematsu T: Endoscopic naso-pancreatic stent-guided single-branch resection of the pancreas for multiple intraductal papillary mucinous adenomas. World J Gastroenterol; 2006 Nov 28;12(44):7203-5
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  • In benign or low-grade malignant pancreatic tumors, complete removal of the lesion is sufficient for a cure, and thus minimal resection techniques with preservation of the pancreatic functional reserve have advantages over more extended pancreatic resections.
  • We describe an endoscopic naso-pancreatic stent-guided single-branch resection of the pancreas for branch-type multiple intraductal papillary mucinous adenomas, along with a gastric wall-covering method for the prevention of pancreatic leakage.
  • [MeSH-major] Adenoma / surgery. Endoscopy, Digestive System / methods. Pancreas / surgery. Pancreatic Neoplasms / surgery

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  • [Cites] Am J Surg. 2000 Jun;179(6):482-4 [11004335.001]
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  • (PMID = 17131488.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087787
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84. Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body. Dig Surg; 2008;25(1):46-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIM: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body.
  • Postoperative complications occurred in 6 patients (43%): 5 had pancreatic fistulas and 1 had a gastric ulcer.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / surgery. Adenoma, Islet Cell / surgery. Carcinoma, Intraductal, Noninfiltrating / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery

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  • (PMID = 18292661.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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85. Haziri A, Juniku-Shkololli A, Gashi Z, Berisha D, Haziri A: Helicobacter pylori infection and precancerous lesions of the stomach. Med Arh; 2010;64(4):248-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helicobacter pylori infection and precancerous lesions of the stomach.
  • INTRODUCTION: Chronic atrophic gastritis, intestinal metaplasia, hereditary non-polyposos colon cancer, gastric dysplasia, gastric adenoma, Barrett esophagitis and familiar adenomatous polyposis are confirmed precancerous lesions of the stomach.
  • -in patients with intestinal metaplasia: 71.7%, with gastric dysplasia: 71.4%, with gastric ulcer: 68.4%, with atrophic gastritis: 66.0% and with Barrett esophagitis: 55.0%.
  • CONCLUSIONS: Precancerous lesions of stomach are associated with high percentage of Helicobacter pylori infection.
  • [MeSH-major] Helicobacter Infections / complications. Helicobacter pylori. Precancerous Conditions / microbiology. Stomach Neoplasms / microbiology

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  • (PMID = 21246927.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
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86. Park MJ, Kim DH, Lim SH, Yim JY, Kim YS, Cho KR, Kim CH, Jung HC, Song IS, Kim SS, Yoon DH, Shin CS, Cho SH, Oh BH, Lee DH: Features of Gastric Neoplasm Detected during the Screening Examination. Gut Liver; 2007 Jun;1(1):33-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Features of Gastric Neoplasm Detected during the Screening Examination.
  • BACKGROUND/AIMS: Gastric cancer is the leading malignancy in Korea and early detection through the health screening seems to be important.
  • The aims of this study were to investigate the features of gastric neoplasms detected during screening, and to figure out the risk factors of these lesions.
  • RESULTS: Of 25, 432 subjects, 122 cases of gastric neoplasms were detected including 61 adenocarcinoma (45 early gastric cancers), 53 adenoma, 7 mucosa-associated lymphoid tissue lymphoma, and one metastatic cancer.
  • There was no significant statistical difference in basal characteristics of the subjects between gastric adenocarcinoma and adenoma.
  • When comparing with the control group those without gastric neoplasms, smoking history, family history of stomach cancer, and H. pylori seropositivity were found to be significant risk factors for gastric neoplasms.
  • Metabolic syndrome was more prevalent in adenoma than in the control (p<0.05).
  • CONCLUSIONS: The health screening may be beneficial in early detection of gastric cancer.
  • In addition, metabolic syndrome might be related with gastric adenoma.

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  • (PMID = 20485656.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2871660
  • [Keywords] NOTNLM ; Adenoma / Gastric cancer / Helicobacter pylori / Risk factor / Screening / Stomach
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87. Jung MK, Jeon SW, Park SY, Cho CM, Tak WY, Kweon YO, Kim SK, Choi YH, Bae HI: Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation. Surg Endosc; 2008 Dec;22(12):2705-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation.
  • BACKGROUND: Currently, endoscopic resections, including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), are widely performed for the management of gastric neoplasia.
  • Gastric adenoma was diagnosed initially for all the patients.
  • These variables were analyzed and compared between an adenoma group (51 cases) and a carcinoma group (63 cases) on the basis of postresection diagnosis.
  • The diameter of the lesions was 14.6 +/- 8.2 mm in the adenoma group and 15.4 +/- 7.4 mm in the carcinoma group.
  • Characteristics of gastric adenomas such as a depressed type, red color, and ulceration that may have foci of carcinomas in other parts of the adenomas also should be considered for endoscopic resection.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Gastroscopy. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Disease Progression. Dissection / methods. Female. Gastric Mucosa / pathology. Humans. Male. Middle Aged. Risk Factors. Stomach Ulcer / etiology. Stomach Ulcer / pathology

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  • (PMID = 18401651.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Imaeda H, Hosoe N, Ida Y, Kashiwagi K, Morohoshi Y, Suganuma K, Nagakubo S, Komatsu K, Suzuki H, Saito Y, Aiura K, Ogata H, Iwao Y, Kumai K, Kitagawa Y, Hibi T: Novel technique of endoscopic submucosal dissection using an external grasping forceps for superficial gastric neoplasia. Dig Endosc; 2009 Apr;21(2):122-7
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  • [Title] Novel technique of endoscopic submucosal dissection using an external grasping forceps for superficial gastric neoplasia.
  • Endoscopic submucosal dissection (ESD) for early stage gastric cancer (EGC) has improved the success rate of en bloc resection but results in perforation more often than does endoscopic mucosal resection.
  • A total of 265 lesions with EGC or gastric adenoma were enrolled in this study.
  • Sixteen lesions were located in the upper third portion of the stomach, 114 in the middle third portion, and 135 in the lower third portion.
  • It was difficult to carry out this procedure when the lesions were located in the cardia, lesser curvature, or posterior wall of the upper third of the gastric body.
  • The endoscopic submucosal dissection using an external grasping forceps for superficial gastric neoplasia is efficacious and safe.
  • [MeSH-major] Gastric Mucosa / surgery. Gastroscopy / methods. Stomach Neoplasms / surgery

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  • (PMID = 19691787.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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89. Lee KM, Lee JS, Jung HS, Park DK, Park HS, Hahm KB: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. Cancer Lett; 2010 Jan 1;287(1):44-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis.
  • As much as that a disturbance of tissue homeostasis through dysregulated apoptosis is generally associated with carcinogenesis, gastric carcinogenesis after Helicobacter pylori infection could be the accumulated consequence of imbalances between apoptosis and proliferation.
  • Since sonic hedgehog (Shh) has been reported to play versatile roles in various tumorigenesis, we hypothesized that late reactivation of sonic hedgehog by H. pylori infection results in population of gastric epithelial cells that are resistant to apoptosis.
  • For clinical relevance, the expressions of Shh were compared in tissues from gastric adenoma or adenocarcinoma according to H. pylori infection.
  • Significantly higher expressions of Shh were seen in H. pylori-associated gastric cancers than H. pylori-not associated gastric cancer.
  • Late reactivation of sonic hedgehog by H. pylori infection results in population of gastric epithelial cells that are resistant to apoptosis and imposes proliferative changes under the background of atrophic gastritis, providing the carcinogenic basis.
  • [MeSH-major] Apoptosis. Gastric Mucosa / pathology. Hedgehog Proteins / physiology. Helicobacter pylori / pathogenicity. Stomach Neoplasms / etiology

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  • Hazardous Substances Data Bank. CYCLOPAMINE .
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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19540662.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human; 0 / Veratrum Alkaloids; 136601-57-5 / Cyclin D1; ZH658AJ192 / cyclopamine
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90. Lee HS, Choe G, Park KU, Park DJ, Yang HK, Lee BL, Kim WH: Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer. Int J Oncol; 2007 Oct;31(4):859-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
  • To determine the protein expression and clinical implications of DNA-PKcs in gastric carcinogenesis and cancer progression, we evaluated its expression status by immunohistochemistry in 122 non-neoplastic gastric mucosa samples, and in 115 gastric adenomas and 564 consecutive gastric cancers.
  • In addition, we evaluated the clinicopathologic characteristics of gastric cancers showing altered DNA-PKcs expression, and performed microsatellite instability (MSI) analysis at BAT-26 and frameshift mutation analysis of DNA-PKcs.
  • DNA-PKcs expression was negative in foveolar epithelium of normal gastric mucosal tissues, but was positive in most Helicobacter pylori-associated gastritis, intestinal metaplasia and gastric adenoma tissues.
  • In gastric cancers, negative expression of DNA-PKcs was found in 114 of the 564 (20.2%) cancers and was significantly associated with intratumoral neutrophils, MSI-high (H) phenotype, tumor progression, and poor patient survival (p<0.05).
  • Frameshift mutations of (A)10 mononucleotide repeats in DNA-PKcs were found in 24.3% of MSI-H gastric cancers and these were associated with negative expression of DNA-PKcs.
  • Although patients with MSI-H gastric cancers were found to have a lower risk of lymph node metastasis, gastric cancers harboring the (A)10 mutation of DNA-PKcs were found to have a higher risk of lymph node metastasis.
  • In conclusion, the expression of DNA-PKcs was found to be altered during gastric carcinogenesis and negative DNA-PKcs expression was associated with gastric cancer progression.
  • The (A)10 frameshift mutation of DNA-PKcs in gastric cancers was a target of defective mismatch repair, and was associated with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / enzymology. DNA-Activated Protein Kinase / genetics. DNA-Activated Protein Kinase / metabolism. Stomach Neoplasms / enzymology
  • [MeSH-minor] Adenocarcinoma, Mucinous / enzymology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / virology. Adenoma / enzymology. Adenoma / genetics. Adenoma / virology. DNA Mismatch Repair. Female. Frameshift Mutation. Gastric Mucosa / enzymology. Gastric Mucosa / pathology. Gene Expression Regulation, Neoplastic. Helicobacter Infections / complications. Helicobacter Infections / genetics. Helicobacter Infections / virology. Helicobacter pylori / pathogenicity. Humans. Intestinal Neoplasms / enzymology. Intestinal Neoplasms / genetics. Intestinal Neoplasms / virology. Lymphatic Metastasis / genetics. Male. Metaplasia / enzymology. Metaplasia / genetics. Metaplasia / virology. Microsatellite Instability. Middle Aged. Neoplasm Invasiveness / genetics

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  • (PMID = 17786318.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.11.1 / DNA-Activated Protein Kinase
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91. Szalóki T, Tóth V, Tiszlavicz L, Czakó L: [Diagnostic and therapeutic use of endoscopic resection of gastric mucosa]. Orv Hetil; 2006 Mar 19;147(11):501-7
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  • [Title] [Diagnostic and therapeutic use of endoscopic resection of gastric mucosa].
  • [Transliterated title] A gyomor endoszkópos mucosaresectiója--diagnosztikus és terápiás módszer.
  • BACKGROUND: EMR is a widely used treatment option for gastric adenoma and early gastric cancer, but, there are no data on its use in Hungary.
  • The diagnosis at first biopsy was in situ carcinoma in 3, adenoma with no dysplasia in 19, adenoma with low-grade dysplasia in 2, adenoma with moderate-grade dysplasia in 6, adenoma with high-grade dysplasia in 7, and hyperplastic lesion in 17 cases.
  • The histology of EMR revealed in situ carcinoma in 5, carcinoid in 1, gastrointestinal stromal tumor in 1, adenoma with no dysplasia in 14, adenoma with low-grade dysplasia in 3, adenoma with moderate-grade dysplasia in 9, adenoma with high-grade dysplasia in 1, hyperplastic lesion in 21, and no diagnosis in 1 case.
  • There were no gastric cancer-related deaths during the median follow-up of 33 (1-90) months.
  • In the follow up period we could not observe gastric malignancy in the previously hyperplastic polyp cases.
  • Among adenoma cases one recurrence was seen in the same place and one in another location.
  • One hyperplastic residuum occurred and in one case adenoma has grown in the same place.
  • Biopsy is generally unreliable to diagnose gastric adenoma.
  • Lesions should be fully resected by EMR for a final diagnosis and (depending on the lesion size and type) possibly definitive treatment.
  • [MeSH-major] Gastric Mucosa / surgery. Gastroscopy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery. Laser Therapy. Male. Middle Aged

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  • (PMID = 16607858.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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92. Yaman B, Nart D, Yilmaz F, Coker A, Zeytunlu M, Kilic M: Biliary intraductal papillary mucinous neoplasia: three case reports. Virchows Arch; 2009 May;454(5):589-94
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  • b-IPMN is classified as adenoma, borderline tumor, carcinoma in situ, and carcinoma, from benign to malignant.
  • Using a different classification, b-IPMNs are subdivided into intestinal, pancreatobiliary, gastric, or oncocytic based on morphology of the cells forming the lesion and expression of MUC1, MUC2, and MUC5 gene proteins in the mucin family.

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  • (PMID = 19347361.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1
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93. Lee JH, Cho JY, Choi MG, Kim JS, Choi KD, Lee YC, Jang JY, Chun HJ, Seol SY: Usefulness of autofluorescence imaging for estimating the extent of gastric neoplastic lesions: a prospective multicenter study. Gut Liver; 2008 Dec;2(3):174-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of autofluorescence imaging for estimating the extent of gastric neoplastic lesions: a prospective multicenter study.
  • BACKGROUND/AIMS: The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE).
  • METHODS: A total of 102 lesions (48 EGCs and 54 gastric adenomas) found in 98 patients were removed endoscopically or surgically.

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  • [Cites] Hepatogastroenterology. 2006 Jul-Aug;53(70):643-7 [16995480.001]
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  • (PMID = 20485643.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2871640
  • [Keywords] NOTNLM ; Adenoma / Fluorescence / Gastric cancer / Imaging / Resection
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94. Park SY, Yoo EJ, Cho NY, Kim N, Kang GH: Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection. J Pathol; 2009 Dec;219(4):410-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection.
  • CpG island hypermethylation and genomic DNA hypomethylation are found not only in gastric cancers but also in associated premalignant lesions.
  • Helicobacter pylori infection induces aberrant CpG island hypermethylation in gastric mucosae.
  • The present study characterized methylation changes in a subset of genes and repetitive DNA elements (ALU, LINE-1, SAT2) and examined their relationship with H. pylori infection in premalignant lesions of gastric cancers.
  • We performed MethyLight analysis of 25 genes and SAT2 and COBRA analysis of ALU and LINE-1 in 212 gastric tissue samples. H. pylori infection was closely associated with enhanced hypermethylation of CpG island loci in chronic gastritis samples, but this association was not found among intestinal metaplasias, gastric adenomas and gastric cancers.
  • The number of methylated genes was greater in intestinal metaplasia and gastric adenoma samples than in chronic gastritis samples, regardless of H. pylori infection.
  • Methylation of repetitive DNA elements in gastric lesions generally decreased with progression of the gastric lesion along the multistep carcinogenesis.
  • No difference was noted in the number of methylated genes in chronic gastritis or intestinal metaplasia between gastric cancer patients and non-cancer subjects.
  • In conclusion, we found that there was no enhanced CpG island hypermethylation in gastric cancer and premalignant lesions in association with H. pylori infection and our findings suggest that CpG island hypermethylation and repetitive DNA hypomethylation are enhanced with progression of the gastric lesion through the multistep carcinogenesis, regardless of the status of H. pylori infection.
  • [MeSH-major] CpG Islands / genetics. DNA Methylation / genetics. DNA, Neoplasm / genetics. Precancerous Conditions / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adenoma / genetics. Adenoma / microbiology. Cell Transformation, Neoplastic / genetics. Chronic Disease. Disease Progression. Female. Gastric Mucosa / pathology. Gastritis / genetics. Gastritis / microbiology. Helicobacter Infections / complications. Helicobacter Infections / genetics. Helicobacter pylori. Humans. Male. Metaplasia / genetics. Metaplasia / microbiology

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  • (PMID = 19639607.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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95. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In his past history, he had undergone distal gastrectomy for a gastric adenoma 17 years before.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery
  • [MeSH-minor] Adenoma / surgery. Humans. Lymph Node Excision. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach Neoplasms / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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96. Spalding DR, Isla AM, Thompson JN, Williamson RC: Pancreas-sparing distal duodenectomy for infrapapillary neoplasms. Ann R Coll Surg Engl; 2007 Mar;89(2):130-5
MedlinePlus Health Information. consumer health - Intestinal Cancer.

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  • RESULTS: There were 9 men and 5 women of median age 56 years, who presented with iron-deficiency anaemia (n = 8), gastric outlet obstruction (n = 4), anaemia and gastric outlet obstruction (n = 1), epigastric pain or mass (1 each).
  • There were 11 malignant neoplasms (adenocarcinoma 5, stromal tumour 4, recurrent seminoma 1, plasmacytoma 1), 2 benign neoplasms (villous adenoma, lipoma) and 1 patient with steroid-induced ulceration.
  • Median operation time was 240 min and median blood loss 1197 ml, being greater for malignant than benign lesions (1500 ml versus 700 ml).
  • There was one death from gangrenous cholecystitis, one early re-operation for anastomotic bleeding and one late re-operation for delayed gastric emptying secondary to anastomotic stricture, but no pancreatic complications.

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  • (PMID = 17346405.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964558
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97. Carlo JT, DeMarco D, Smith BA, Livingston S, Wiser K, Kuhn JA, Lamont JP: The utility of capsule endoscopy and its role for diagnosing pathology in the gastrointestinal tract. Am J Surg; 2005 Dec;190(6):886-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Arteriovenous malformation (AVM) was the most common reported finding (43.9%), followed by ulcer (24.1%), colon or gastric pathology (14.1%), mass/tumor (9.1%), and stricture (6.9%).
  • Patients with abdominal pain (n = 81) had findings 46.9% of the time including edema/ulcer (47.4%), stricture (10.5%), mass/tumor (26.3%), gastric pathology (10.5%), AVM (2.6%), or sprue (2.6%).
  • Pathology at the retention site included benign strictures or adhesions (n = 9, 75%), Crohn's stricture (n = 1, 8.3%) carcinoid tumor (n = 1, 8.3%), and villous adenoma (n = 1, 8.3%).
  • [MeSH-major] Endoscopy, Gastrointestinal / utilization. Gastrointestinal Diseases / diagnosis. Miniaturization. Telemetry / instrumentation

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  • (PMID = 16307940.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Iacconi P, Donatini G, Iacconi C, De Bartolomeis C, Cucinotta M, Puccini M, Miccoli P: Unexpected histological findings of lesions diagnosed in the adrenal region in a series of 420 patients submitted to adrenal surgery. Review of our experience. J Endocrinol Invest; 2008 Oct;31(10):873-6
MedlinePlus Health Information. consumer health - Adrenal Gland Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The incidence of adrenal incidentalomas is reported to be up to 30% in the current literature; nevertheless, in some patients undergoing surgery, a final diagnosis of non-adrenal origin of the mass is performed.
  • Pre-operative diagnosis was: incidentaloma (34.0% of patients), Conn's adenoma (29.0%), Cushing's adenoma (13.9%), pheochromocytoma (8.8%), suspicious metastasis (7.3%), Cushing's disease (6.0%), other (1.0%).
  • RESULTS: Final histology revealed an unexpected diagnosis of non-adrenal origin of the mass in 13 patients (3.1%).
  • Histology demonstrated a benign neurogenic tumor in 10 patients.
  • In the other 3 patients diagnosis was respectively of lymphnode, hemangioma and a gastric metastasis of melanoma.
  • [MeSH-major] Adrenal Gland Diseases / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenalectomy / methods

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  • (PMID = 19092291.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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99. M'sakni I, Rommani SR, Ben Kahla S, Najjar T, Ben Jilani S, Zermani R: Another case of serrated adenoma of the stomach. J Clin Pathol; 2007 May;60(5):580-1
Hazardous Substances Data Bank. Barium sulfate .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Another case of serrated adenoma of the stomach.
  • [MeSH-major] Adenoma / radiography. Stomach Neoplasms / radiography

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  • (PMID = 17513520.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
  • [Other-IDs] NLM/ PMC1994541
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100. Uemura N: [Gastric adenoma, hyperlastic polyp and fundic gland polyp]. Nihon Rinsho; 2005 Nov;63 Suppl 11:560-4
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastric adenoma, hyperlastic polyp and fundic gland polyp].
  • [MeSH-major] Adenoma. Polyps. Stomach Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Gastroscopy. Humans

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  • (PMID = 16363601.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 8
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