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1. Liu DC, Yang ZL, Yang LP: [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Jul;33(7):618-22
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  • [Title] [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder].
  • OBJECTIVE: To examine the expressive level of enhancer of zesle homolog 2 (EZH2) and phosphatase and tension homolog (PTEN), and to explore its clinicopathological significance in benign and malignant lesion of gallbladder.
  • METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).
  • RESULTS: The positive rate of EZH2 was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (chi(2) = 24.49, P < 0.01), adenomatous polyp(chi(2) = 11.68, P < 0.01), and chronic cholecystitis (chi(2) = 31.62, P < 0.01).
  • The benign lesions in the positive cases of EZH2 and (or) the negative ones of PTEN showed the moderately- or severely- atypical hyperplasia of gallbladder epithelium.
  • The positive rate of PTEN was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues(n = 20.20, P < 0.01), adenomatous polyp(chi(2)=10.81, P<0.01), and chronic cholecystitis (n = 29.83, P < 0.01).The positive rates of EZH2 were significantly lower in the highly-differentiated adenocarcinoma, the maximal diameter of mass < 2 cm, non-metastasis of lymphnodes, and non-infiltration of regional tissues than those in the moderately or low-differentiated adenocarcinoma, the maximal diameter > or = 2 cm, metastasis of lymphnode, and infiltration of regional tissues (P < 0.05 or P < 0.01).
  • High inconsistency was found between the expression of EZH2 and PTEN in gallbladder adenocarcinoma (P < 0.05).
  • CONCLUSION: Expression of EZH2 and/or PTEN might be important biological markers in the carcinogenesis, progression, biological behaviors and prognosis of gallbladder adenocarcinoma.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Gallbladder Neoplasms / genetics. PTEN Phosphohydrolase / biosynthesis. Transcription Factors / biosynthesis
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Biomarkers, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Polycomb Repressive Complex 2. Prognosis

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  • (PMID = 18667776.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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2. Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N: Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol; 2008 Oct 14;14(38):5933-7
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  • [Title] Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction.
  • A 71-year-old Japanese man with acute cholecystitis and an incarcerated gallbladder (GB) stone was admitted.
  • We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris.
  • Amylase levels in the common bile duct and gallbladder were quite high.
  • Thus, we diagnosed it as a gallbladder cancer, based on histopathological analysis of the resected specimen.
  • We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies.
  • [MeSH-major] Adenocarcinoma / pathology. Biliary Tract / abnormalities. Gallbladder Neoplasms / pathology. Incidental Findings. Pancreas / abnormalities
  • [MeSH-minor] Aged. Cholangiography. Cholecystectomy, Laparoscopic. Cholecystitis, Acute / surgery. Fatal Outcome. Gallstones / surgery. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Necrosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 18855999.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2751910
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3. Kwon W, Jang JY, Lee SE, Hwang DW, Kim SW: Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer. J Korean Med Sci; 2009 Jun;24(3):481-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer.
  • It is difficult to differentiate benign and malignancy in polypoid lesions of the gallbladder (PLG) by solely depending on imaging studies.
  • Therefore clinicopathologic features of benign and malignant polyps are compared in an attempt to identify the risk factors of malignant polypoid lesions.
  • The medical records of 291 patients who were confirmed to have PLG through cholecystectomy were reviewed and analyzed for age, sex, symptom, associated gallstone, morphology of PLG, size of PLG, number of PLG, and preoperative tumor markers.
  • Benign PLG was found in 256 patients (88.0%) and malignant PLG in 35 patients (12.0%).
  • Compared with benign group, the malignant group were older (61.1 yr vs. 47.1 yr, P<0.001), more often accompanied with symptoms (62.9% vs. 28.9%, P<0.001).
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Polyps / pathology

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  • (PMID = 19543513.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2698196
  • [Keywords] NOTNLM ; Gallbladder / Gallbladder Neoplasms / Polyps / Risk Factors
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4. von Meyenfeldt EM, Mantel SF, Gouma DJ, van Gulik TM: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 May 12;151(19):1049-54
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  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblaas; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • In a 59-year-old woman with pain in the right upper abdomen, echography and CT-scan revealed adenomatosis of the gallbladder.
  • In a 46-year-old man with fever and weight loss, echography revealed two polyps in the gallbladder.
  • In a 63-year-old man with systemic symptoms, a biopsy of the echographically diagnosed tumour of the gallbladder revealed that he had actually had cholecystitis.
  • Following cholecystectomy, an adenocarcinoma of the gallbladder was found.
  • Patients with a tumour in the gallbladder are often diagnosed with gallbladder cancer, which has a poor prognosis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Polyps / diagnosis. Polyps / surgery. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1653; author reply 1653 [17727189.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1652-3; author reply 1653 [17729454.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1083-6 [17552418.001]
  • (PMID = 17552411.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
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5. Tan Y, Meng HP, Wang FQ, Cheng ZN, Wu Q, Wu HR: [Comparative proteomic analysis of human gallbladder carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):29-32
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  • [Title] [Comparative proteomic analysis of human gallbladder carcinoma].
  • OBJECTIVE: To find out potential molecular targets for gallbladder carcinoma diagnosis and treatment by analyzing and comparing the proteins expressed in human gallbladder carcinoma tissue and benign gallbladder tissue.
  • METHODS: Proteomic analysis of 6 human gallbladder carcinoma tissues and 6 benign gallbladder tissues was carried out.
  • Total proteins of the carcinoma tissue and benign gallbladder tissue were separated by two-dimensional gel electrophoresis (2-DE).
  • There were forty six differentially expressed proteins in the gallbladder carcinom tissues.
  • The increased level of PEBP1 protein in gallbladder carcinoma was further confirmed by immunohistochemical analysis.
  • Those results may provide scientific foundation for screening the molecular biomarkers which can be used in diagnosis and treatment of gallbladder carcinoma, as well as to improve its prognosis and provide a new clue for carcinogenesis research of gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Profiling. Phosphatidylethanolamine Binding Protein / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Electrophoresis, Gel, Two-Dimensional. Gallstones / diagnosis. Gallstones / metabolism. Gallstones / pathology. Humans. Immunohistochemistry. Middle Aged. Proteomics / methods. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 20211063.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PEBP1 protein, human; 0 / Phosphatidylethanolamine Binding Protein
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6. Palade R, Grigoriu M, Voiculescu D: [Gallbladder leiomyoma]. Chirurgia (Bucur); 2006 Jul-Aug;101(4):415-8
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  • [Title] [Gallbladder leiomyoma].
  • [Transliterated title] Leiomiomul de veziculă biliară.
  • Leiomyoma, benign tumor generated by wall's smooth muscle proliferation, is extremely rare revealed.
  • The echographic exam may suggest sometimes the diagnosis but the presence of the stones makes it harder, especially when the bladder has scleroathrophic lesions.
  • The differential diagnosis with gallbladder carcinoma is necessary especially for medium dimensions tumors.
  • Laparoscopic cholecystectomy is the sufficient and recommended procedure; only even the benignity of the tumor is pathologically established.
  • [MeSH-major] Gallbladder Neoplasms. Leiomyoma
  • [MeSH-minor] Aged. Cholecystectomy, Laparoscopic. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 17059154.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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7. Kumar Y, Chahal A, Garg M, Bhutani A: Occult gallbladder carcinoma presenting as a primary ovarian tumor in two women: two case reports and a review of the literature. J Med Case Rep; 2010;4:202

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occult gallbladder carcinoma presenting as a primary ovarian tumor in two women: two case reports and a review of the literature.
  • However, little is known about gallbladder carcinoma metastasizing to the ovaries and presenting as a primary ovarian tumor.
  • CASE PRESENTATION: We report two cases of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumor in a 35-year-old and a 62-year-old North Indian woman.
  • Clinically, both our patients presented with abdominal masses without obvious signs and symptoms related to gallbladder carcinoma.
  • Radiology suggested the possibility of a primary ovarian tumor with chronic cholecystitis and cholelithiasis.
  • The gross features also mimicked a primary malignant ovarian tumor in the first case and a benign mucinous neoplasm in the second case.
  • Exact diagnoses could only be made after thorough sampling from both the ovaries and gallbladder.
  • CONCLUSIONS: Gallbladder carcinoma with metastasis to the ovaries can mimic both malignant and benign primary ovarian tumors.
  • Extensive cystic change in the ovary due to metastasis from gallbladder carcinoma has rarely been reported.

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  • (PMID = 20591172.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2908110
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8. Whittle C, Hepp J, Soto E, Niedmann J, Cortés M: [Pseudotumoral adenomyomatosis of the gallbladder diagnosed by ultrasound. Report of one case]. Rev Med Chil; 2007 Feb;135(2):212-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pseudotumoral adenomyomatosis of the gallbladder diagnosed by ultrasound. Report of one case].
  • Adenomyomatosis of the gallbladder wall is a frequent benign degenerative hyperplasia of unknown etiology.
  • In some cases it looks like a malignant tumor.
  • The diagnosis can be suspected during ultrasound examination.
  • The ultrasound showed a gallbladder mass with small cyst and echogenic spot inside that suggested the presence of Rokitansky-Ashoff sinuses, seen in adenomyomatosis.
  • The patient was operated and the tumor was excised.
  • The pathological examination of the surgical specimen confirmed the presence of gallbladder adenomyomatosis.
  • [MeSH-major] Adenomyoma / ultrasonography. Gallbladder / pathology. Gallbladder Diseases / ultrasonography
  • [MeSH-minor] Adult. Carcinoma / ultrasonography. Diagnosis, Differential. Gallbladder Neoplasms / ultrasonography. Humans. Hyperplasia / ultrasonography. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17406739.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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9. Clarke T, Matsuoka L, Jabbour N, Mateo R, Genyk Y, Selby R, Gagandeep S: Gallbladder mass with a carbohydrate antigen 19-9 level in the thousands: malignant or benign pathology? Report of a case. Surg Today; 2007;37(4):342-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder mass with a carbohydrate antigen 19-9 level in the thousands: malignant or benign pathology? Report of a case.
  • Tumor markers such as carbohydrate antigen 19-9 (CA 19-9) are commonly measured in the serum of patients with suspected pancreaticobiliary malignancies.
  • Moderate elevations of CA 19-9 may be seen in benign disease, but levels in the thousands are indicative of malignancy.
  • We report the case of a 64-year-old man with an elevated CA 19-9 of 5791 U/ml and radiological findings suggestive of metastatic gallbladder carcinoma.
  • [MeSH-major] Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Cholecystitis / blood. Granuloma / blood. Xanthomatosis / blood
  • [MeSH-minor] Cholecystectomy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17387571.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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10. Choi SB, Han HJ, Kim CY, Kim WB, Song TJ, Suh SO, Kim YC, Choi SY: Incidental gallbladder cancer diagnosed following laparoscopic cholecystectomy. World J Surg; 2009 Dec;33(12):2657-63
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental gallbladder cancer diagnosed following laparoscopic cholecystectomy.
  • BACKGROUND: Laparoscopic cholecystectomy (LC) is the treatment of choice for benign gallbladder disease.
  • Gallbladder cancers have been found following LC.
  • The aim of the present study was to evaluate the survival outcome and prognosis of incidental gallbladder cancer diagnosed after LC.
  • Of these, 33 patients (1.05%) were diagnosed with gallbladder cancer after LC.
  • Regarding tumor staging, there were 2 Tis, 6 T1a, 4 T1b, 17 T2, and 4 T3 tumors.
  • Univariate analysis revealed that significant prognostic factors for poorer survival were male gender (P = 0.026), age older than 65 years (P = 0.013), the presence of inflammation (P = 0.009), moderately or poorly differentiated tumor (P < 0.001), nonpolypoid gross type (P = 0.003), and pT stage (P < 0.001).
  • Tumor differentiation was a significantly independent predictor of poor prognosis.
  • CONCLUSIONS: Male patients exhibited aggressive tumor characteristics.
  • For pT2 and pT3 patients, additional radical surgery might be needed to achieve a tumor-free surgical margin, along with lymph node dissection.
  • [MeSH-major] Cholecystectomy, Laparoscopic. Gallbladder / pathology. Gallbladder Neoplasms / surgery

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  • (PMID = 19823903.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Chaube A, Tewari M, Singh U, Shukla HS: CA 125: a potential tumor marker for gallbladder cancer. J Surg Oncol; 2006 Jun 15;93(8):665-9
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  • [Title] CA 125: a potential tumor marker for gallbladder cancer.
  • BACKGROUND: CA 125 is a glycoprotein and a commonly used tumor marker in ovarian carcinoma.
  • Its use in gallbladder carcinoma (GBC) has not yet been reported.
  • We have henceforth examined for the first time the diagnostic utility of CA 125 in patients with gallbladder diseases.
  • CA 125 at cut off value of 11 U/ml yielded 64% sensitivity and 90% specificity in differentiating benign from malignant gallbladder disease.
  • A higher level of CA 125 was found in presence of gallbladder mass, weight loss, ascites and loss of appetite compared to patients with GSD.
  • [MeSH-major] Biomarkers, Tumor / blood. CA-125 Antigen / blood. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Ascites / diagnosis. Enzyme-Linked Immunosorbent Assay. Female. Gallstones / diagnosis. Humans. Lymph Nodes / pathology. Male. Neoplasm Staging. ROC Curve. Sensitivity and Specificity

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16724349.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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12. Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol; 2009 Dec;40(12):1686-92
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  • [Title] Reg IV expression and clinicopathologic features of gallbladder carcinoma.
  • In this study, we examined Reg IV expression in the gallbladder and gallbladder carcinoma, and measured Reg IV levels in sera from patients with gallbladder carcinoma.
  • Quantitative reverse transcription-polymerase chain reaction revealed that high Reg IV levels were identified in 17 of 31 gallbladder carcinomas, whereas there was no apparent amplification in normal gallbladders.
  • Immunohistochemically, although only a small part of the epithelium with intestinal metaplasia in 2 of 4 cases with adenomyomatosis showed Reg IV expression, Reg IV was negative in all cases with normal gallbladder (n = 15) and cholelithiasis (n = 13).
  • In contrast, 34 (56%) of 61 gallbladder carcinomas were positive.
  • Multivariate analysis revealed negative Reg IV expression, as well as hepatic parenchymal invasion, to be independently associated with a poor prognosis in patients with advanced gallbladder carcinoma.
  • Before surgical resection, 4 (33%) of 12 patients with gallbladder carcinoma had high serum Reg IV levels, whereas Reg IV was never elevated in 12 patients with benign diseases.
  • These results suggest that Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery.
  • The serum level of Reg IV may be of use or indicative of neoplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Lectins, C-Type / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Enzyme-Linked Immunosorbent Assay. Gene Expression. Homeodomain Proteins / biosynthesis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Metaplasia / genetics. Metaplasia / metabolism. Metaplasia / pathology. Neoplasm Staging. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19716164.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Lectins, C-Type; 0 / REG4 protein, human
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13. Reddy SK, Clary BM: Surgical management of gallbladder cancer. Surg Oncol Clin N Am; 2009 Apr;18(2):307-24, ix
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  • [Title] Surgical management of gallbladder cancer.
  • This article describes the epidemiology, risk factors, diagnostic imaging tools, and operative management of gallbladder cancer.
  • The rarity of gallbladder cancer coupled with the prevalence of benign gallbladder disease mean that most patients undergo initial procedures that violate tumor planes, complicating attempts at future oncologic resection.
  • [MeSH-major] Gallbladder Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Staging

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  • (PMID = 19306814.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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14. Albores-Saavedra J, Galliani C, Chable-Montero F, Batich K, Henson DE: Mucin-containing Rokitansky-Aschoff sinuses with extracellular mucin deposits simulating mucinous carcinoma of the gallbladder. Am J Surg Pathol; 2009 Nov;33(11):1633-8
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  • [Title] Mucin-containing Rokitansky-Aschoff sinuses with extracellular mucin deposits simulating mucinous carcinoma of the gallbladder.
  • Rokitansky-Aschoff sinuses (R-As) are epithelial invaginations that extend down the gallbladder wall through the smooth muscle gaps and by this pathway they reach the subserosal connective tissue.
  • They were compared with 10 mucinous carcinomas of the gallbladder.
  • The remaining 4 patients complained of right upper quadrant pain and had a thickened gallbladder wall identified by computed tomography and magnetic resonance imaging.
  • The overlying surface gallbladder epithelium exhibited papillary hyperplasia with focal intestinal metaplasia in 2 patients, one of which had metachromatic leukodystrophy.
  • The lack of reactivity for carcinoembryonic antigen and p53 and the low proliferative activity as measured by MIB-1 labeling index provided additional support to the benign nature of the lesion.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Mucins / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Child, Preschool. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucous Membrane / metabolism. Mucous Membrane / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Jan;35(1):153-4 [21164300.001]
  • (PMID = 19738458.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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15. Nishiyama Y, Yamamoto Y, Fukunaga K, Kimura N, Miki A, Sasakawa Y, Wakabayashi H, Satoh K, Ohkawa M: Dual-time-point 18F-FDG PET for the evaluation of gallbladder carcinoma. J Nucl Med; 2006 Apr;47(4):633-8
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  • [Title] Dual-time-point 18F-FDG PET for the evaluation of gallbladder carcinoma.
  • Conventional imaging techniques such as ultrasonography, CT, and MRI are able to detect gallbladder abnormalities but are not always able to differentiate a malignancy from other disease processes such as cholecystitis.
  • The purpose of the present study was to evaluate the efficacy of dual-time-point (18)F-FDG PET for differentiating malignant from benign gallbladder disease.
  • METHODS: The study evaluated 32 patients who were suspected of having gallbladder tumors. (18)F-FDG PET (whole body) was performed at 62 +/- 8 min (early) after (18)F-FDG injection and was repeated 146 +/- 14 min (delayed) after injection only in the abdominal region.
  • The tumor-to-liver ratio was also calculated.
  • RESULTS: The final diagnosis was gallbladder carcinoma in 23 patients and benign disease in 9 patients.
  • For visual analysis of gallbladder carcinoma, delayed (18)F-FDG PET images improved the specificity of diagnosis in 2 patients.
  • When an SUV(early) of 4.5, SUV(delayed) of 2.9, and RI of -8 were chosen as arbitrary cutoffs for differentiating between malignant and benign conditions, sensitivity increased from 82.6% to 95.7% and 100% for delayed imaging and combined early and delayed imaging (i.e., RI), respectively.
  • For gallbladder carcinoma, both SUV and tumor-to-liver ratios derived from delayed images were significantly higher than the ratios derived from early images (P < 0.0001).
  • [MeSH-major] Cholecystitis / radionuclide imaging. Fluorodeoxyglucose F18. Gallbladder Neoplasms / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Positron-Emission Tomography. Whole-Body Counting

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  • [ErratumIn] J Nucl Med. 2006 Aug;47(8):1266
  • (PMID = 16595497.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. Li Q, Yang Z: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res; 2009;28:65
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  • [Title] Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
  • However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and pathological significance of ERK1/2 and PI3-K/AKT signaling changes in gallbladder adenocarcinoma.
  • In this study, we examined phospho-ERK1/2 (p-ERK1/2) and PI3K expression and analyzed its clinicopathological impact in gallbladder adenocarcinoma.
  • METHODS: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens.
  • RESULTS: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis.
  • The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P < 0.01), adenomatous polyps (p-ERK1/2, P < 0.01; PI3-K, P < 0.05), and chronic cholecystitis (both, P < 0.01).
  • Moreover, the frequency of p-ERK1/2 expression in gallbladder adenocarcinomas without gallstone was significantly lower than those with gallstones.
  • Multivariate Cox regression analysis showed that increased p-ERK1/2 expression was an independent prognostic predictor in gallbladder carcinoma (P = 0.028).
  • CONCLUSION: Increased expression of p-ERK1/2 and PI3K might contribute to gallbladder carcinogenesis. p-ERK1/2 over-expression is correlated with decreased survival and therefore may serve as an important biological marker in development of gallbladder adenocarcinoma.
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Phosphorylation. Prognosis. Survival Rate

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  • (PMID = 19445727.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
  • [Other-IDs] NLM/ PMC2691734
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17. Piekarski JH, Kusinska R, Nejc D, Pluta P, Sek P, Bilski A, Durczynski A, Kubiak R, Pasz-Walczak G, Jeziorski A: Recurrence of cholangiogenous carcinoma in port-sites two years after laparoscopic removal of noncancerous gallbladder. Eur J Gastroenterol Hepatol; 2008 May;20(5):474-7

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  • [Title] Recurrence of cholangiogenous carcinoma in port-sites two years after laparoscopic removal of noncancerous gallbladder.
  • We present a unique case of carcinoma diagnosed in port-site, two years after uncomplicated laparoscopic cholecystectomy for benign cholecystitis.
  • Analysis of morphology and cytokeratin profile (CK19+ and CK20+/-) of resected port-site tumor allows us to establish the diagnosis of tubular carcinoma with probable cholangiogenic origin.
  • The primary carcinoma was not diagnosed in archival gallbladder tissue, despite repeated histological examination.
  • No other primary tumor was identified during follow-up.
  • Patient history and histological/immunohistochemical picture of the recurrent tumor suggested that primary carcinoma was probably located in the gallbladder, but was not detected during initial and repeated histological examinations of postoperative specimen.
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Seeding

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  • (PMID = 18403952.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Akatsu T, Ueda M, Shimazu M, Wakabayashi G, Aiura K, Tanabe M, Kawachi S, Kido H, Kitajima M: Long-term survival of patients with gallbladder cancer detected during or after laparoscopic cholecystectomy. World J Surg; 2005 Sep;29(9):1106-9, discussion 1110
MedlinePlus Health Information. consumer health - Gallbladder Diseases.

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  • [Title] Long-term survival of patients with gallbladder cancer detected during or after laparoscopic cholecystectomy.
  • Little evidence is available regarding long-term survival of patients with gallbladder cancer that is discovered at the time of laparoscopic cholecystectomy (LC).
  • Of 1546 patients who underwent LC for benign gallbladder disease between January 1992 and January 2002, 8 patients (0.5%) had cancers that were found during or after LC.
  • The gallbladder was resected without perforation in all cases.
  • In conclusion, before and during LC, we have not overlooked T2 or more advanced tumor, which requires additional procedures for curative resection.
  • We consider that an intensive preoperative work-up and meticulous inspection of the opened gallbladder should be mandatory to detect gallbladder cancer in patients who undergo LC.
  • [MeSH-major] Cholecystectomy, Laparoscopic. Gallbladder Diseases / surgery. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Frozen Sections. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • [Journal-full-title] World journal of surgery
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19. Oshikiri T, Morita T, Fujita M, Miyasaka Y, Senmaru N, Yamada H, Kaji N, Kondo S: Resection of lung metastasis from gallbladder carcinoma: immunohistochemistry of RCAS1 and CD8+T cells in primary and metastatic tumors. Cancer Lett; 2006 Jun 8;237(1):115-22
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  • [Title] Resection of lung metastasis from gallbladder carcinoma: immunohistochemistry of RCAS1 and CD8+T cells in primary and metastatic tumors.
  • Advanced Gallbladder cancer has an extremely poor prognosis.
  • We examined a patient with resectable gallbladder cancer with associated lung metastasis.
  • A 64-year-old female patient, diagnosed with gallbladder cancer and a solitary benign lung tumor by imaging, was subjected to extensive cholecystectomy and extrahepatic bile duct resection.
  • After one year, a follow-up CT indicated enlargement of the lung tumor; video-assisted right middle lobectomy was then performed.
  • The lung tumor was diagnosed as a metastasis derived from the gallbladder cancer by pathology and immunohistochemistry.
  • Expression of RCAS1, an independent unfavorable prognostic indicator in gallbladder cancer, was observed in both the gallbladder and lung tumors.
  • However, infiltration of CD8+T cells was only seen in the lung metastatic tumor.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Antigens, Neoplasm / metabolism. CD8-Positive T-Lymphocytes / pathology. Gallbladder Neoplasms / metabolism. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Lymphocytes, Tumor-Infiltrating / pathology

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  • (PMID = 16039043.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / EBAG9 protein, human
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20. Goetze TO, Paolucci V: Immediate re-resection of T1 incidental gallbladder carcinomas: a survival analysis of the German Registry. Surg Endosc; 2008 Nov;22(11):2462-5
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  • [Title] Immediate re-resection of T1 incidental gallbladder carcinomas: a survival analysis of the German Registry.
  • BACKGROUND: Incidental gallbladder carcinoma (IGBC) is a carcinoma first detected by the pathologist.
  • The indication for cholecystectomy is a benign disease.
  • The indication for immediate re-resection (IRR) in the case of T1b incidental gallbladder carcinoma (IGBC) is debated in the literature, and different recommendations often are drawn on the basis of data collected from only small groups.
  • The rate of tumor recurrence was three times lower in the T1b group that underwent IRR.
  • [MeSH-major] Gallbladder Neoplasms / mortality. Gallbladder Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Germany / epidemiology. Humans. Incidental Findings. Male. Neoplasm Recurrence, Local. Prospective Studies. Registries. Surveys and Questionnaires. Survival Analysis

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  • [CommentIn] Surg Endosc. 2009 Jul;23(7):1680 [19360366.001]
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  • (PMID = 18247090.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH: Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol; 2008 Jul;27(3):366-79
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  • [Title] Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases.
  • Information on ovarian metastasis of carcinoma of the extrahepatic bile ducts and gallbladder is limited.
  • Sixteen examples are reported; 3 primary tumors were hilar cholangiocarcinomas, 5 common bile duct carcinomas, and 8 gallbladder carcinomas.
  • The primary tumor was identified before the detection of the ovarian lesions in 5 cases, was simultaneously detected with the ovarian metastases in 9, and was diagnosed postoperatively in 2.
  • Mucinous epithelial differentiation was seen in 81%, sometimes with foci of benign-like or borderline-like epithelium simulating primary ovarian mucinous neoplasia.
  • Signet ring cells were present in sufficient quantity for a diagnosis of Krukenberg tumor in four tumors.
  • Although the diagnosis of a metastatic tumor to the ovary is possible in most of the cases based on standard diagnostic criteria, problems in the differential diagnosis may be posed by morphologic patterns that overlap strikingly with primary ovarian neoplasms, benign, borderline, and malignant, as discussed herein.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18580314.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Lin WR, Lin DY, Tai DI, Hsieh SY, Lin CY, Sheen IS, Chiu CT: Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: analysis of 34 669 cases. J Gastroenterol Hepatol; 2008 Jun;23(6):965-9
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  • [Title] Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: analysis of 34 669 cases.
  • BACKGROUND AND AIM: Gallbladder (GB) polyps are tumor or tumor-like projections arising from GB mucosa.
  • Although most polyps are benign, some early GB carcinomas present as polypoid lesions.
  • The diagnosis of GB polyps is relatively easy by ultrasonography.
  • [MeSH-major] Asian Continental Ancestry Group / statistics & numerical data. Gallbladder Neoplasms / epidemiology. Gallbladder Neoplasms / ultrasonography. Polyps / epidemiology. Polyps / ultrasonography

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  • (PMID = 17725602.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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23. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Any localisation is possible, although surface lesions (head, neck, trunk, extremities) are far more common than visceral ones (esophagus, stomach, small and large bowel, larynx, bronchi, gallbladder and biliary tract).
  • Surgical en-block excision is curative for both benign an malignant forms.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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24. Albores-Saavedra J, Grider DJ, Wu J, Henson DE, Goodman ZD: Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells. Am J Surg Pathol; 2006 Apr;30(4):495-500
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  • [Title] Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells.
  • We report four previously undescribed primary giant cell tumors of the extrahepatic biliary tree and morphologically compare them with 10 anaplastic spindle and giant cell carcinomas with osteoclast-like giant cells of the gallbladder.
  • Two giant cell tumors were located in the distal common bile duct; one in the cystic duct and one in the gallbladder.
  • The 3 patients with bile duct tumors were male, and the only patient with a gallbladder tumor was a female.
  • The patients with bile duct tumors presented with biliary obstruction, and the patient with a gallbladder tumor presented with symptoms of cholelithiasis and a gallbladder mass.
  • The benign osteoclast-like giant cells showed immunoreactivity for CD68 and HAM 56 but were negative for CD163 and cytokeratins.
  • Giant cell tumors of the extrahepatic biliary tree are benign true histiocytic neoplasms that should be distinguished from the highly lethal anaplastic spindle and giant cell carcinomas with osteoclast-like giant cells by detailed cytologic analysis and immunohistochemical stains for CD163, CD68, HAM 56, and cytokeratins.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma / diagnosis. Cholestasis, Extrahepatic / etiology. Cholestasis, Extrahepatic / pathology. Cholestasis, Extrahepatic / surgery. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Male. Middle Aged. Osteoclasts / pathology

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  • [CommentIn] Am J Surg Pathol. 2008 Feb;32(2):335-7; author response 337 [18223338.001]
  • (PMID = 16625096.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Na Chiangmai W, Young RH: Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia. Am J Surg Pathol; 2007 Dec;31(12):1788-99
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  • [Title] Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia.
  • Although an origin in the gallbladder or extrahepatic bile ducts is acknowledged for some cases little information exists on tumors originating within the intrahepatic bile ducts.
  • Foci often mimicked mucinous borderline tumors of typical type or with intraepithelial carcinoma and benign-appearing mucinous epithelium was seen in 62% of tumors.
  • Intrahepatic cholangiocarcinoma should be included in the list of origins of possible ovarian metastatic tumors that mimic primary ovarian mucinous neoplasia, particularly in parts of the world where cholangiocarcinoma of the liver is relatively common.
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18043033.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Nilsson HO, Stenram U, Ihse I, Wadstrom T: Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients. World J Gastroenterol; 2006 May 21;12(19):3038-43
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  • METHODS: Patients with exocrine pancreatic cancer (n = 40), neuroendocrine cancer (n = 14), multiple endocrine neoplasia type 1 (n = 8), and chronic pancreatitis (n = 5) were studied.
  • Other benign pancreatic diseases (n = 10) and specimens of normal pancreas (n = 7) were included as controls.
  • From a subset of the pancreatic cancer patients, gastric and/or duodenal tissue as well as gallbladder and ductus choledochus tissue were analyzed.
  • Gallbladder and choledochus samples were included as controls.
  • RESULTS: Helicobacter DNA was detected in pancreas (tumor and/or surrounding tissue) of 75% of patients with exocrine cancer, 57% of patients with neuroendocrine cancer, 38% of patients with multiple endocrine neoplasia, and 60% of patients with chronic pancreatitis.
  • All samples from other benign pancreatic diseases and normal pancreas were negative.
  • All gallbladder and ductus choledochus specimens were negative for helicobacter.
  • [MeSH-major] Carcinoma, Neuroendocrine / microbiology. DNA, Ribosomal / analysis. Duodenum / chemistry. Helicobacter / genetics. Multiple Endocrine Neoplasia Type 1 / microbiology. Pancreas / chemistry. Pancreatic Neoplasms / microbiology. Stomach / chemistry
  • [MeSH-minor] Adult. Aged. Bacteroides / genetics. Bacteroides / physiology. Case-Control Studies. Common Bile Duct / chemistry. Common Bile Duct / microbiology. Female. Gallbladder / chemistry. Gallbladder / microbiology. Helicobacter Infections / complications. Helicobacter Infections / genetics. Humans. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 16718784.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Ribosomal
  • [Other-IDs] NLM/ PMC4124378
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27. Bloomston M, Kneile J, Butterfield M, Dillhoff M, Muscarella P, Ellison EC, Melvin WS, Croce CM, Pichiorri F, Huebner K, Frankel WL: Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Ann Surg Oncol; 2009 Aug;16(8):2331-8
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  • Wwox has been understudied in pancreatobiliary cancers, especially in relation to other involved tumor suppressors.
  • We have assessed the status of the Fhit and Wwox proteins encoded by DNA damage susceptible chromosome fragile sites encompassed by FHIT and WWOX tumor suppressor genes.
  • METHODS: Pancreatic, gallbladder and ampullary cancers, normal pancreas, chronic pancreatitis, and benign gallbladder specimens were stained for expression of Fhit, Fhit effector protein Fdxr, Wwox, and other tumor suppressors by immunohistochemistry, and comparisons were made between benign and malignant tissue.
  • RESULTS: Fhit and Wwox were ubiquitously expressed in benign samples and significantly and coordinately reduced in pancreatic, gallbladder, and ampullary cancers.
  • Neither Fhit nor Wwox expression correlated with expression of other tumor suppressors or with clinicopathologic characteristics measured.
  • CONCLUSION: Loss of Fhit and Wwox expression does not predict tumor progression or patient survival, suggesting that loss of expression of genes at the exquisitely replication stress sensitive chromosome fragile regions is an early event in the pathogenesis of cancers of the gallbladder, pancreas, and ampulla.

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  • (PMID = 19434452.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115965; United States / NCI NIH HHS / CA / R01 CA115965-03; United States / NCI NIH HHS / CA / CA133250-01; United States / NCI NIH HHS / CA / R01 CA132453-02; United States / NCI NIH HHS / CA / CA132453; United States / NCI NIH HHS / CA / K12 CA133250-01; United States / NCI NIH HHS / CA / K12 CA133250; United States / NCI NIH HHS / CA / CA132453-02; United States / NCI NIH HHS / CA / CA115965-03; United States / NCI NIH HHS / CA / CA133250; United States / NCI NIH HHS / CA / R01 CA115965; United States / NCI NIH HHS / CA / R01 CA132453
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
  • [Other-IDs] NLM/ NIHMS128319; NLM/ PMC2719793
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28. Modlin IM, Shapiro MD, Kidd M: An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg; 2005 Jan;29(1):92-101
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  • The primary organs in which carcinoids are most commonly mistaken for some of the more conspicuous endemic tumors include the esophagus, pancreas, liver, biliary tract, gallbladder, and Meckel's diverticulum, as well as within the pelvic and otolaryngeal organs and the breast.
  • The diminution of the likelihood of inadvertently neglecting these often benign, indolent neoplasms that are well known to metastasize if unaddressed would represent an important advance.
  • [MeSH-major] Carcinoid Tumor / surgery
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic. Breast Neoplasms / surgery. Esophageal Neoplasms / surgery. Female. Gallbladder Neoplasms / surgery. Humans. Laryngeal Neoplasms / surgery. Liver Neoplasms / surgery. Male. Ovarian Neoplasms / surgery. Pancreatic Neoplasms / surgery. Testicular Neoplasms / surgery. Uterine Cervical Neoplasms / surgery

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  • (PMID = 15599742.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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29. Jarnagin WR, Klimstra DS, Hezel M, Gonen M, Fong Y, Roggin K, Cymes K, DeMatteo RP, D'Angelica M, Blumgart LH, Singh B: Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. J Clin Oncol; 2006 Mar 1;24(7):1152-60
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  • METHODS: Tissue microarrays were prepared from paraffin-embedded surgical specimens with triplicate cores of BTA and benign tissue.
  • Tumor sites of origin were intrahepatic cholangiocarcinoma (IH; n = 23), hilar cholangiocarcinoma (Hilar; n = 54), gallbladder (GB; n = 32), and distal bile duct (Distal; n = 19).
  • CONCLUSION: BTAs differentially express cell cycle-regulatory proteins based on tumor location and morphology.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Biomarkers, Tumor / analysis. Cell Cycle Proteins / analysis. Cholangiocarcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Aged. Cyclin D1 / analysis. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Proliferating Cell Nuclear Antigen / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis. Proto-Oncogene Proteins c-mdm2 / analysis. Survival Analysis. Tumor Suppressor Protein p53 / analysis. Up-Regulation

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  • (PMID = 16505435.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / p27 antigen; 136601-57-5 / Cyclin D1; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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30. Rungsinaporn K, Phaisakamas T: Frequency of abnormalities detected by upper abdominal ultrasound. J Med Assoc Thai; 2008 Jul;91(7):1072-5

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  • The finding of a liver mass, as the second positive finding, was observed in 209 patients (6.2%); of which were 124 patients (59.3%) with hepatic cyst, 51 patients (24.4%) with hemangioma, 16 patients (7.7%) with indetermined nodule, 11 patients (5.3%) with calcification, and 7 patients (3.4%) with malignant tumor while 664 patients (19.5%) had other positive findings.
  • The top four included gallbladder polyp observed in 181 patients (5.3%), renal cyst observed in 155 patients (4.6%), gallstone observed in 141 patients (4.2%), and renal stone observed in 101 patients (3.0%).
  • Although the majority of positive findings were benign conditions, some of them might have an adverse effect to the health condition of patients in the long run.

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  • (PMID = 18839847.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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31. Kefeli M, Gonullu G, Can B, Malatyalioglu E, Kandemir B: Metastasis of adenocarcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature. Int J Gynecol Pathol; 2009 Jul;28(4):343-6
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  • SUMMARY: Polyps are the most common benign lesions in the endometrium.
  • Metastasis to the endometrial polyp from a distant primary tumor is rare.
  • After this diagnosis, bone metastases were detected during radiologic screening.
  • Gastrointestinal tumor metastasis to an endometrial polyp is a very rare event, but if a patient with a known primary extragenital tumor has abnormal vaginal bleeding, the possibility of metastasis should be included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / secondary. Gallbladder Neoplasms / pathology. Polyps / pathology
  • [MeSH-minor] Aged. Dilatation and Curettage. Female. Humans. Immunohistochemistry. Neoplasm Staging

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  • (PMID = 19483630.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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32. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
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  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. DNA-Binding Proteins / analysis. Epithelial Cells / pathology. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Mucins / analysis. Mucins / classification. Pancreaticoduodenectomy. Pepsinogen A / analysis. Smad4 Protein. Trans-Activators / analysis. Treatment Outcome. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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33. Galitskiĭ MV, Khomeriki SG, Nikiforov PA: [Expression of proliferation and apoptosis markers in neoplasms of colon mucosa after cholecystectomy]. Eksp Klin Gastroenterol; 2009;(5):28-32
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  • Fifty patients (40 with retained function of gallbladder and 10 patients with cholecystectomy) histologically diagnosed as proximal colon adenoma or adenocarcinoma were included into the study.
  • Thus, in benign colorectal tumors at the patients with retained function of gallbladder intensifying of epithelial cells proliferation is not accompanied with intensifying of apoptosis, and in malignant tumors a complete supression of apoptosis is observed.
  • [MeSH-major] Apoptosis. Biomarkers, Tumor / biosynthesis. Cell Proliferation. Cholecystectomy. Colon / metabolism. Colonic Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Intestinal Mucosa / metabolism. Ki-67 Antigen / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 20205327.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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34. Hughes NR, Goodman ZD, Bhathal PS: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol; 2010 Sep;34(9):1312-8
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  • Here, we compare the expression of 13 tissue antigens in bile duct adenomas, other benign bile duct lesions, and various foregut-derived tissues, to further investigate the bile duct adenoma phenotype and pathogenesis.
  • The acini of pyloric gland metaplasia in gallbladder and terminal ileum also stained for D10, 1F6, MUC6, and TFF2, with MUC5AC focally present in the gastric foveolar metaplasia overlying the pyloric gland metaplasia but not in the metaplastic glands.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunoenzyme Techniques. Intestines / metabolism. Intestines / pathology. Liver / metabolism. Liver / pathology. Male. Middle Aged. Mucins / metabolism. Phenotype. Young Adult

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  • (PMID = 20679879.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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35. Konishi M, Kinoshita T, Nakagohri T, Takahashi S, Gotohda N, Ryu M: Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies. Hepatogastroenterology; 2007 Apr-May;54(75):753-7
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  • BACKGROUND/AIMS: Pancreas-sparing duodenectomy (PSD) represents an attractive operation for benign or premalignant duodenal disease.
  • METHODOLOGY: The present study investigated 16 patients who underwent PSD for duodenal neoplasms including adenoma, cancer, carcinoid and non-epithelial tumor.
  • Although 1 patient with gallbladder cancer died postoperatively due to the results of a concomitant operation, no postoperative deaths or re-operations related to PSD were encountered.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Treatment Outcome

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  • (PMID = 17591055.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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36. Da Ines D, Petitcolin V, Lannareix V, Montoriol P, Joubert Zakeyh J, Boyer L, Garcier J: [Liver capsule retraction adjacent to a circumscribed liver lesion: review of 26 cases with histological confirmation]. J Radiol; 2009 Sep;90(9 Pt 1):1067-74
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  • [Transliterated title] Rétraction capsulaire hépatique en regard d'une lésion circonscrite: à propos de 26 patients avec preuve histologique.
  • PURPOSE: To review the histological features of 26 circumscribed liver lesions associated with liver capsule retraction and discuss the differential diagnosis while evaluating for the presence of fibrous stromal reaction.
  • RESULTS: Twenty-one patients had benign or malignant liver tumors and 5 patients had confluent hepatic fibrosis.
  • Twenty of 21 liver tumors were malignant (95.2%): 3 intra-hepatic cholangiocarcinoma, 17 cases of metastatic disease including colorectal carcinoma (n=8), bronchogenic carcinoma (n=1), pancreatic carcinoma (n=4), esophageal carcinoma (n=1), breast carcinoma (n=1), gallbladder carcinoma (1) and endocrine neoplasm of the pancreas (n=1), and 1 case of liver sclerosing angioma (n=1).
  • In keeping with previous reports, metastases were frequently the cause and intrahepatic cholangiocarcinoma was the most frequent primary tumor.

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  • [CommentIn] J Radiol. 2009 Sep;90(9 Pt 1):1019-20 [19752803.001]
  • (PMID = 19752810.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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37. Robertson AG, Davidson BR: Mirizzi syndrome complicating an anomalous biliary tract: a novel cause of a hugely elevated CA19-9. Eur J Gastroenterol Hepatol; 2007 Feb;19(2):167-9
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  • The possibility of benign disease must be considered even with very high levels of the cancer marker CA19-9 or the opportunity for curative surgery may be missed.
  • [MeSH-major] Biliary Tract / abnormalities. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Gallbladder Neoplasms / diagnosis. Gallstones / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. False Positive Reactions. Humans. Male. Syndrome

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  • (PMID = 17273004.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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38. Wu M, Yuan S, Szporn AH, Gan L, Shtilbans V, Burstein DE: Immunocytochemical detection of XIAP in body cavity effusions and washes. Mod Pathol; 2005 Dec;18(12):1618-22
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  • We performed an immunocytochemical survey of XIAP expression in cell blocks from benign and malignant body cavity effusions and washes.
  • The prevalence of staining for specific malignancies varied with the tissue of origin as follows: ovarian (13/13, 100%); lung (9/11, 82%), breast (6/13, 46%); gastric (4/7, 57%), colon (0/4, 0%), pancreas (2/3, 67%), gallbladder (1/1, 100%), fallopian tube (1/3, 33%), endometrial (6/7, 86%), mesothelioma (4/5, 80%), carcinoma of unknown primary (5/5, 100%) and hematopoietic malignancies (3/9, 33%).
  • Benign effusions (n = 35) were virtually XIAP-negative except for two cases (6%) in which histiocytes showed moderate staining.
  • XIAP immunostaining, when strong, allows for ready distinction of malignant from benign and reactive cell populations.
  • The degree of XIAP staining of tumor cells may be a means of identifying the most therapy-resistant cases (ie, those with strong XIAP expression), and allow additional triaging to XIAP-blocking drugs presently being developed and clinically tested.
  • [MeSH-major] Ascitic Fluid / chemistry. Biomarkers, Tumor / analysis. Immunoenzyme Techniques / methods. Peritoneal Lavage. Pleural Effusion, Malignant / chemistry. X-Linked Inhibitor of Apoptosis Protein / analysis

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  • (PMID = 16118627.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / X-Linked Inhibitor of Apoptosis Protein
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39. Benchellal ZA, Soro KG, Orain I, Poret H, Ferhi AH, Darquies-Chevalley J: Thirteen-year disease-free survival after surgery for cystic duct carcinoma: a case report. Case Rep Gastroenterol; 2008 Sep;2(3):428-32

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  • Preoperative diagnosis of cystic duct tumor was carried in a 66-year-old male.
  • Under the diagnosis of carcinoma of the cystic duct, the patient underwent en bloc resection of the gallbladder, cystic duct, hepaticocholedochus and lymph node dissection.
  • Five months later the patient underwent second look surgery for benign obstruction of the hepaticojejunal anastomosis.

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  • [Cites] Am J Surg. 2007 Jun;193(6):738-9 [17512287.001]
  • [Cites] Dig Surg. 1998;15(3):273-8 [9845599.001]
  • [Cites] Hepatogastroenterology. 2005 May-Jun;52(63):691-4 [15966184.001]
  • [Cites] J Gastrointest Surg. 2003 Jul-Aug;7(5):631-4 [12850675.001]
  • [Cites] J Gastroenterol. 2001 Apr;36(4):276-80 [11324733.001]
  • (PMID = 21897794.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3166806
  • [Keywords] NOTNLM ; Carcinoma / Cystic duct / Disease-free survival / Extrahepatic bile duct / Surgery
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40. Huis M, Stulhofer M, Szerda F, Vukić T, Bubnjar J: [Obstruction icterus--our experience]. Acta Med Croatica; 2006;60(1):71-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The most common causes of extrahepatic obstruction are choledocholithiasis, malignant and benign stenosis of biliary ducts, pancreatic head carcinoma, and chronic cephalic pancreatitis.
  • Differential diagnosis usually includes a combination of clinical examination, biochemical testing, ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP), transhepatic cholangiography, computed tomography (CT), nuclear magnetic resonance (NMR) and endoscopic ultrasonography (EUS).
  • Choledocholithiasis mostly develops due to concrement migration from the gallbladder.
  • Malignant stenoses of extrahepatic ducts can involve any segment of the biliary ducts or the gallbladder.
  • Intraoperative lesion occurring on biliary duct procedures is generally involved in the etiology of benign stenoses of extrahepatic biliary ducts.
  • Icterus was caused by choledocholithiasis in 112, carcinoma of extrahepatic biliary ducts in seven, carcinoma of the gallbladder in five, and carcinoma of the head of pancreas in 18 patients.
  • Biliodigestive anastomosis was created in another 20 patients with the findings of inoperable tumor of the head of pancreas, inoperable tumor of the papilla of Vater, postoperative choledochus stenosis, stenosis of choledochoduodenal anastomosis, and chronic cephalic pancreatitis.
  • Operative treatment can be fully successful in cases caused by lithiasis or benign stenosis, whereas in cases due to malignant disease a variety of radical and operative procedures associated with a variable level of success are available.
  • Timely diagnosis, well planned and properly performed operative procedures could considerably improve the results achieved by the operative treatment of the disease.

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  • (PMID = 16802577.001).
  • [ISSN] 1330-0164
  • [Journal-full-title] Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti
  • [ISO-abbreviation] Acta Med Croatica
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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41. Shiroshita H, Komori Y, Tajima M, Bandoh T, Arita T, Shiraishi N, Kitano S: Laparoscopic examination and resection for giant lipoma of the omentum: a case report and review of related literature. Surg Laparosc Endosc Percutan Tech; 2009 Oct;19(5):e217-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 71-year-old male patient was admitted with a diagnosis of sigmoid colon cancer.
  • During preoperative examination, a gallbladder stone and an intra-abdominal giant lipoma were accidentally diagnosed.
  • Laparoscopic examination revealed a smooth-surfaced, giant yellow tumor at the lower border of the greater omentum that was unattached to the surrounding organs.
  • After laparoscopic resection of the tumor and cholecystectomy, a 10-cm midline incision was made in the lower abdomen to remove the tumor and the gallbladder.
  • The resected tumor measured 29 x 19 x 3 cm and weighed 1250 g, and a histopathologic examination revealed a benign lipoma.

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  • (PMID = 19851258.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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42. Mosnier JF, Kandel C, Cazals-Hatem D, Bou-Hanna C, Gournay J, Jarry A, Laboisse CL: N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol; 2009 Feb;22(2):182-90
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As a definite immunoprofile of this tumor is missing, the histopathologic diagnosis of intrahepatic cholangiocarcinoma is difficult.
  • The aim of this study was to explore E- and N-cadherin expressions in intrahepatic bile duct tumors, and to determine their potential interest in differential diagnosis.
  • Tissue-microarrays including 20 esophageal, 86 gastric, 8 small bowel, 64 colonic, 18 pancreatic, 6 gallbladder, and 7 extrahepatic biliary tract adenocarcinomas, 22 hepatocellular carcinomas, and normal tissues were constructed.
  • All the benign lesions and 30 of the 45 intrahepatic cholangiocarcinomas (23/29 peripheral and 7/16 hilar) also expressed N-cadherin.
  • The expression of N-cadherin at the plasma membrane of tumor cells was significantly more frequent in peripheral than in hilar intrahepatic cholangiocarcinomas (P=0.003).
  • Among noncholangiocarcinomas, only 1% gastric and 66% gallbladder adenocarcinomas and all the hepatocellular carcinomas expressed N-cadherin at the membrane of tumor cells.
  • Finally, for the diagnosis of intrahepatic cholangiocarcinomas, the specificity value of membranous expression of N-cadherin was 88%, whereas that of the combination cytokeratin 7/membranous N-cadherin was 98%.
  • In combination with cytokeratin 7 and Hep Par1, N-cadherin is a reliable tool for the histopathological diagnosis of primary hepatic tumors.
  • [MeSH-major] Antigens, CD / analysis. Bile Duct Neoplasms / immunology. Bile Ducts, Intrahepatic / immunology. Biomarkers, Tumor / analysis. Cadherins / analysis. Cholangiocarcinoma / immunology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. France. Humans. Immunoblotting. Immunohistochemistry. Keratin-7 / analysis. Male. Middle Aged. Predictive Value of Tests. Reproducibility of Results. Tissue Array Analysis

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  • (PMID = 18622386.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CDH1 protein, human; 0 / CDH2 protein, human; 0 / Cadherins; 0 / KRT7 protein, human; 0 / Keratin-7
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43. Larentzakis A, Theodorou D, Fili K, Manataki A, Bizimi V, Tibishrani M, Katsaragakis S: Sister Mary Joseph's nodule: Three case reports. Cases J; 2008;1(1):182

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively.
  • CONCLUSION: The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms.

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  • [Cites] Radiographics. 1998 Mar-Apr;18(2):413-31 [9536487.001]
  • [Cites] Ann Intern Med. 1998 Mar 1;128(5):410 [9490607.001]
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  • (PMID = 18816407.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2561010
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44. Ho H, Mahajan A, Gosain S, Jain A, Brock A, Rehan ME, Ellen K, Shami VM, Kahaleh M: Management of complications associated with partially covered biliary metal stents. Dig Dis Sci; 2010 Feb;55(2):516-22
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Partially covered metal stents (PCMS) have been increasingly used for both malignant and benign biliary indications.
  • RESULTS: PCMS were placed in 396 patients (247 with malignant biliary strictures and 149 with benign biliary disease).
  • There were six cases of stent occlusion due to debris or sludge (1.6%), four cases of pancreatitis (1%), four cases of tumor overgrowth (1%), three cases of benign stenosis in the uncovered portion of the PCMS (0.8%), two cases of abdominal pain (0.5%), one case of an infected biloma (0.3%), and one case of a liver abscess (0.3%).
  • Their management includes endoscopic revision, cholecystectomy, and gallbladder drainage.

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  • (PMID = 19267200.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible
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45. Katayama M, Funakoshi A, Sumii T, Sanzen N, Sekiguchi K: Laminin gamma2-chain fragment circulating level increases in patients with metastatic pancreatic ductal cell adenocarcinomas. Cancer Lett; 2005 Jul 8;225(1):167-76
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The G2F levels in patients with benign pancreatic tumours (pancreatic cysts and intraductal papillary mucinous tumours) were similar to that in healthy volunteers.
  • Interestingly, a significant increase in circulating G2F/G1F ratio was observed in patients with bile duct and gallbladder carcinoma, as well as in those with metastatic pancreatic ductal cell adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / blood. Carcinoma, Pancreatic Ductal / genetics. Carcinoma, Pancreatic Ductal / pathology. Cell Adhesion Molecules / blood. Laminin / blood. Liver Neoplasms / secondary. Neoplasm Metastasis. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Case-Control Studies. Female. Gastrointestinal Neoplasms / genetics. Gastrointestinal Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 15922869.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / LAMC2 protein, human; 0 / Laminin; 0 / kalinin
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46. Satgé D, Sasco AJ, Vekemans MJ, Portal ML, Fléjou JF: Aspects of digestive tract tumors in Down syndrome: a literature review. Dig Dis Sci; 2006 Nov;51(11):2053-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Due to intellectual disability, persons with Down syndrome do not convey their symptoms and pain, leading to delayed diagnosis and potentially worse outcome.
  • It is thus important to know which organs are at risk for tumors and possible tumor risk factors.
  • In a review of the literature, we found 13 benign tumors and 127 cancers in 1 fetus, 8 children, and 131 adults with Down syndrome.
  • The review suggests a decreased incidence of digestive cancer, however, with a possible increased incidence of neoplasms of the pancreas and gallbladder.

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  • (PMID = 17009117.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 103
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47. Oh SJ, Lee SJ, Lee HY, Paik YH, Lee DK, Lee KS, Chung JB, Yu JS, Yoon DS: [Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. Korean J Gastroenterol; 2009 Sep;54(3):162-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas].
  • BACKGROUND/AIMS: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has a favorable prognosis, but seems to be associated with a high incidence of extrapancreatic tumors.
  • Five, six, and two extrapancreatic malignancies had been diagnosed before, during, and after the diagnosis of IPMN.
  • Other extrapancreatic tumors included lung cancer (n=2), prostatic cancer (n=1), renal cell carcinoma (n=1), cholangiocellular carcinoma (n=1), urinary bladder cancer (n=1), and gallbladder cancer (n=1), respectively.
  • As benign tumor, there were two gallbladder adenoma, one gastric adenoma, one colonic adenoma and one benign ovarian cystic neoplasm, respectively.
  • Upper gastrointestinal endoscopy and colonoscopy should be done, and systemic surveillance for the possible occurrence of other tumors may allow early detection of extrapancreatic tumor in patients with IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] Korean J Gastroenterol. 2009 Sep;54(3):196-8 [19844158.001]
  • (PMID = 19844152.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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48. Puylaert JB, Coerkamp EG: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 Jul 21;151(29):1653; author reply 1653
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblass; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1049-54 [17552411.001]
  • (PMID = 17727189.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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49. Ruijs JH: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 Jul 21;151(29):1652-3; author reply 1653
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblaas; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1049-54 [17552411.001]
  • (PMID = 17729454.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Letter
  • [Publication-country] Netherlands
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50. Yang LP, Yang ZL, Huang JS, Fu X: [Expression of cancer stem cell antigens, prostate stem cell antigen and Oct-4, and its clinicopatholgical significances in benign and malignant lesions of gallbladder]. Zhonghua Bing Li Xue Za Zhi; 2008 Jan;37(1):56-7
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  • [Title] [Expression of cancer stem cell antigens, prostate stem cell antigen and Oct-4, and its clinicopatholgical significances in benign and malignant lesions of gallbladder].
  • [MeSH-major] Antigens, Neoplasm / immunology. Gallbladder Neoplasms / pathology. Neoplastic Stem Cells / immunology. Octamer Transcription Factor-3 / metabolism. Prostatic Neoplasms / pathology
  • [MeSH-minor] Antigens / immunology. Gene Expression Regulation, Neoplastic. Humans. Male. Tumor Cells, Cultured

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  • (PMID = 18509987.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Octamer Transcription Factor-3
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