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1. Reed MJ, Dunn MJ, McKeown DW: Can an airway assessment score predict difficulty at intubation in the emergency department? Emerg Med J; 2005 Feb;22(2):99-102
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  • Patients with large incisors (p<0.001), a reduced inter-incisor distance (p<0.05), or a reduced thyroid to floor of mouth distance (p<0.05) were all more likely to have a poor laryngoscopic view (grade 2, 3, or 4).
  • Patients with a poor laryngoscopic view (grades 2, 3, or 4) were more likely to have large incisors, a reduced inter-incisor distance, and a reduced thyroid to floor of mouth distance.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Head Movements. Humans. Incisor / anatomy & histology. Laryngoscopy. Male. Middle Aged. Mouth / anatomy & histology. Neck / anatomy & histology. Pharynx / anatomy & histology. Prospective Studies. Risk Assessment / methods

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  • (PMID = 15662057.001).
  • [ISSN] 1472-0213
  • [Journal-full-title] Emergency medicine journal : EMJ
  • [ISO-abbreviation] Emerg Med J
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1726680
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2. El-Zohairy MA: Straight midline mandibulotomy: technique and results of treatment. J Egypt Natl Canc Inst; 2007 Dec;19(4):292-8
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  • Twelve patients had primary lesions affecting the anterior two-thirds of the tongue, four at floor of mouth, three at posterior two-thirds of the tongue, two at deep lobe of parotid, one at soft palate and one at tonsil.
  • [MeSH-major] Mandible / surgery. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery

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  • (PMID = 19652672.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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3. Sanderson J, Nunes C, Escudier M, Barnard K, Shirlaw P, Odell E, Chinyama C, Challacombe S: Oro-facial granulomatosis: Crohn's disease or a new inflammatory bowel disease? Inflamm Bowel Dis; 2005 Sep;11(9):840-6
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  • BACKGROUND: Oro-facial granulomatosis (OFG) is a rare chronic inflammatory disorder presenting characteristically with lip swelling but also affecting gingivae, buccal mucosa, floor of mouth, and a number of other sites in the oral cavity.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Antigens / immunology. Biopsy. Child. Colonoscopy. Diagnosis, Differential. Female. Humans. Inflammation. Intestines / immunology. Intestines / pathology. Male. Middle Aged

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  • (PMID = 16116319.001).
  • [ISSN] 1078-0998
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens
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4. Kwon YD, Biesterfeld S, Hansen T, Schwerdtfeger A, Kunkel M: Lymphadenomatous carcinoma of the sublingual gland: report of a first case in an unusual localization. Head Neck; 2008 Oct;30(10):1394-8
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  • BACKGROUND: Lymphadenomatous carcinoma of the salivary gland is a very rare tumor, which hitherto occurred exclusively in the parotid gland.
  • METHODS AND RESULTS: A 36-year-old man was seen with slowly growing mass on his right floor of mouth.

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18327777.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Azizkhan RG, Rutter MJ, Cotton RT, Lim LH, Cohen AP, Mason JL: Lymphatic malformations of the tongue base. J Pediatr Surg; 2006 Jul;41(7):1279-84
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  • In 21 patients, pathology was extensive, involving contiguous anatomical areas such as the anterior tongue, larynx, pharynx, and floor of mouth.

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  • (PMID = 16818063.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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6. Larsen SR, Johansen J, Sørensen JA, Krogdahl A: The prognostic significance of histological features in oral squamous cell carcinoma. J Oral Pathol Med; 2009 Sep;38(8):657-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim was to assess the prognostic value of histological features related to the primary tumour.
  • RESULTS: The predominant sites were floor of mouth (FOM, 39%) and lateral tongue (35%).
  • Nodal involvement at diagnosis was observed in 36% which was significantly related to grade, neural and vascular invasion; surgical margins and increasing tumour depth.
  • A cut-off value of 2 mm (4 mm for FOM) separated patients without and with nodal metastasis at the time of diagnosis.
  • However, on multivariate analysis, neck disease was only associated with tumour depth and grade.
  • Cox analysis of local recurrence in the oral cavity over time showed that tumour diameter and surgical margins were significant predictors while cause-specific survival was related to diameter, depth of invasion, surgical margins and extracapsular spread (ECS).
  • CONCLUSIONS: Tumour depth and grade were strong prognostic factors for nodal metastasis, independently of other histological features.
  • Tumour diameter and margins independently predict local recurrences in the oral cavity as well as cause-specific survival.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Sex Distribution. Statistics, Nonparametric. Survival Analysis. Young Adult


7. Benhidjeb T, Harlaar J, Kerver A, Kleinrensink GJ, Wilhelm T: [Transoral endoscopic thyroidectomy : Part 2: Surgical technique]. Chirurg; 2010 Feb;81(2):134-8
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  • The surgical procedure itself was performed on two further cadavers with the help of one 5 mm trocar and two 3 mm trocars which were introduced bilaterally through the floor of mouth and the oral vestibule.
  • [MeSH-minor] Aged. Aged, 80 and over. Esthetics. Feasibility Studies. Female. Humans. Male. Middle Aged. Mouth Floor / surgery

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  • (PMID = 19876604.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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8. Kirke D, Horwood K, Wallwork B: Floor of mouth and tongue metastasis from malignant pleural mesothelioma. ANZ J Surg; 2010 Jul-Aug;80(7-8):556-8
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  • [Title] Floor of mouth and tongue metastasis from malignant pleural mesothelioma.
  • [MeSH-major] Lymph Nodes / pathology. Mesothelioma / secondary. Mouth Neoplasms / secondary. Pleural Neoplasms / pathology. Tongue Neoplasms / secondary
  • [MeSH-minor] Aged. Biopsy, Needle. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Neck. Neoplasm Staging. Tomography, X-Ray Computed


9. Saleh HA, Clayman L, Masri H: Fine needle aspiration biopsy of intraoral and oropharyngeal mass lesions. Cytojournal; 2008;5:4
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  • The goal of this study was to assess the value and accuracy of FNA biopsy in the diagnosis of oral and oropharyngeal lesions particularly in regards to discriminating benign from malignant tumors.
  • The sites of involvement were: lip 1, maxillary sinus 3, pharynx/oropharynx 5, floor of mouth 4, buccal mucosa 2 and peritonsillar area 1.
  • Cytologically, 7 cases were diagnosed as suspicious/malignant, and 9 cases as benign (including 6 benign neoplasm, 1 atypical, and 2 reactive or "descriptive").
  • Fifteen cases had corresponding surgical resection for histologic examination, of these, 9 cases were interpreted as malignant, and 6 as benign.
  • Two cases were interpreted as benign or atypical cytologically, but were found to be malignant on histologic examination.
  • Furthermore, aspiration biopsy is an important tool in the diagnosis and management of these lesions, both neoplastic and non-neoplastic, and can be sometimes complemented by ancillary studies for more accurate interpretation.
  • However, its sensitivity in the diagnosis of malignancy is lower than that of histologic samples.

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  • (PMID = 18373853.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2329665
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10. Pathak KA, Juvekar AS, Radhakrishnan DK, Deshpande MS, Pai VR, Chaturvedi P, Pai PS, Chaukar DA, D'Cruz AK, Parikh PM: In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy. Indian J Cancer; 2007 Oct-Dec;44(4):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Currently, it is difficult to predict whether a tumor will respond to chemotherapy and which drug(s) will achieve the maximum clinical response.
  • Of these 52 evaluable patients, 47 had primary gingivo-buccal cancers and five had tongue / floor of mouth cancers.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Mouth Neoplasms / drug therapy

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  • (PMID = 18322356.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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11. Billings SD, Henley JD, Summerlin DJ, Vakili S, Tomich CE: Spindle cell lipoma of the oral cavity. Am J Dermatopathol; 2006 Feb;28(1):28-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe the largest series yet of oral spindle cell lipoma involving the tongue (4), buccal mucosa (1), floor of mouth (1), and lip (1).
  • The combination of the histologic features and the immunoreactivity for CD34 confirmed the diagnosis.
  • Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors.
  • [MeSH-major] Lipoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16456321.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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12. Parkins GE, Armah G, Ampofo P: Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study. World J Surg Oncol; 2007;5:48
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study.
  • RESULTS: A total of 394 patients with oro-facial swellings were retrieved from the registry out of which 210 had lower face tumour and tumour-like lesions.
  • The remainder making up 20% were found in the floor of the mouth, tongue and lips.
  • Sixty-two (36.3%) had benign odontogenic tumours and thirty-one (18.1%) had non-odontogenic tumour-like lesions.
  • Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma.
  • The mean age at presentation of all lesions was 40.4 years with over 50% of benign lesions in patients aged between 11 and 30 years.
  • CONCLUSION: Tumours and tumour-like lesions of the lower face comprising the mandible, tongue and adjacent structures are a diverse group of neoplasm and are seen commonly in practice of Maxillofacial surgery.
  • Both malignant and benign tumours are seen in the Ghanaian population.
  • In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.
  • [MeSH-major] Facial Neoplasms / epidemiology. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Mouth Neoplasms / epidemiology. Odontogenic Tumors / epidemiology

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  • (PMID = 17484780.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1885260
  • [General-notes] NLM/ Original DateCompleted: 20070813
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13. Hornstra MT, Alkureishi LW, Ross GL, Shoaib T, Soutar DS: Predictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma. Head Neck; 2008 Jul;30(7):858-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Seven of the 12 patients had cT1/cT2 tumors, and 6 of these were located in the floor of mouth.
  • Factors associated with failure included T classification (p = .01), tumor site (p = .05), and negative preoperative lymphoscintigraphy (p = .0174).
  • CONCLUSION: Successful sentinel lymph node harvest is related to primary tumor site, T classification, and the presence of nodes on preoperative lymphoscintigraphy.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / pathology. Neoplasm Invasiveness / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Cohort Studies. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Preoperative Care / methods. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Failure. Treatment Outcome

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  • (PMID = 18302276.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Hogan LC, Hall GM, Chambers IG: Oral cancer at a Tasmanian tertiary referral clinic, the Royal Hobart Hospital 1996-2002. Aust Dent J; 2005 Mar;50(1):31-6
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  • RESULTS: The distribution of anatomical sites of the oral cancers in this study was as follows: 36 oral tongue lesions, 17 floor of mouth, 13 lip, five retromolar trigone, five mandibular alveolus, six buccal mucosa, nine palatal and 10 minor and major salivary gland cancers.
  • The most common site of oral cancer was the tongue (35.6 per cent), followed by the floor of mouth (16.8 per cent) and lip (12.9 per cent).
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Mouth Neoplasms / mortality
  • [MeSH-minor] Aged. Alcohol Drinking / adverse effects. Cancer Care Facilities. Cause of Death. Female. Humans. Lip Neoplasms / mortality. Male. Mandibular Neoplasms / mortality. Middle Aged. Mouth Floor. Palatal Neoplasms / mortality. Referral and Consultation. Retrospective Studies. Salivary Gland Neoplasms / mortality. Smoking / adverse effects. Tasmania / epidemiology. Tongue Neoplasms / mortality

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  • (PMID = 15881303.001).
  • [ISSN] 0045-0421
  • [Journal-full-title] Australian dental journal
  • [ISO-abbreviation] Aust Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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15. Rivera H, Nikitakis NG, Correnti M, Maissi S, Ponce JG: Oral and oropharyngeal cancer in a Venezuelan population. Acta Odontol Latinoam; 2008;21(2):175-80
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  • We clinically evaluated 130 patients with OC and OPC and a histopathologic diagnosis of squamous cell carcinoma.
  • The most common oropharyngeal anatomic location was the base of the tongue (22.3%), followed by the tonsils (13.9%), while the most frequently affected oral location was the oral tongue (19.2%) followed by the gingiva and alveolar mucosa (10.8%), and the floor of mouth (7.7%).
  • Most tumors were diagnosed at an advanced stage with a high incidence of metastatic spread to the regional lymph nodes, indicating possible delays in diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Mouth Neoplasms / epidemiology. Oropharyngeal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Alcohol Drinking / epidemiology. Cell Differentiation. Female. Gingival Neoplasms / epidemiology. Humans. Lymphatic Metastasis. Male. Middle Aged. Mouth Floor / pathology. Mouth Mucosa / pathology. Neoplasm Staging. Prognosis. Sex Factors. Smoking / epidemiology. Tongue Neoplasms / epidemiology. Tonsillar Neoplasms / epidemiology. Venezuela / epidemiology

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  • (PMID = 19177856.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
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16. Shoaib T, Soutar DS, Macdonald DG, Gray HW, Ross GL: The nodal neck level of sentinel lymph nodes in mucosal head and neck cancer. Br J Plast Surg; 2005 Sep;58(6):790-4
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  • In this study, the sentinel nodes in mucosal head and neck malignancies were mapped according to their site within the neck and this was correlated with tumour site within the oral cavity.
  • Fifty-two necks were explored for sentinel nodes from tumours located in the tongue (23 cases), floor of mouth (12 cases), palate (six cases), retromolar trigone (five cases), alveolus (three cases), buccal mucosa (two cases), tonsil (two cases) and lip (one case).

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  • (PMID = 16040013.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Jaber JJ, Thomas FJ, Carfrae MJ, Galati LT: Radiotherapy-associated euthyroid Graves ophthalmopathy following floor-of-mouth surgery: a case report. Ear Nose Throat J; 2008 Sep;87(9):533-6
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  • [Title] Radiotherapy-associated euthyroid Graves ophthalmopathy following floor-of-mouth surgery: a case report.
  • We report an unusual case of radiotherapy-associated Graves ophthalmopathy 5 months after adjuvant external irradiation of the head and neck in a euthyroid patient who had undergone wide local excision of squamous cell carcinoma from the floor of the mouth.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Graves Ophthalmopathy / etiology. Mouth Neoplasms / pathology. Mouth Neoplasms / radiotherapy. Radiation Injuries / diagnosis
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Follow-Up Studies. Humans. Male. Middle Aged. Mouth Floor / pathology. Mouth Floor / surgery. Oral Surgical Procedures / methods. Radiotherapy Dosage. Radiotherapy, Adjuvant. Risk Assessment. Thyroid Function Tests. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18800329.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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18. Xie WX, Gao L, Chen MF, Feng ZK: [Malignant tumor of the floor of mouth in a patient with membranous nephrosis: Report of one case]. Shanghai Kou Qiang Yi Xue; 2009 Oct;18(5):559-60
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  • [Title] [Malignant tumor of the floor of mouth in a patient with membranous nephrosis: Report of one case].
  • The tumor-relevant antigen holds an important position in the elder's membranous nephropathy.
  • This article reported a case of malignant tumor of mouth floor complicated with membranous nephropathy, and discussed some problems that were encountered during clinical care.
  • It's believed that only radical resection of the malignant tumor of the mouth floor for this kind of patient can achieve good results from the therapy of membranous nephropathy.
  • [MeSH-major] Glomerulonephritis, Membranous. Mouth Floor. Nephrosis

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  • (PMID = 19907870.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Woo BM, Al-Bustani S, Ueeck BA: Floor of mouth haemorrhage and life-threatening airway obstruction during immediate implant placement in the anterior mandible. Int J Oral Maxillofac Surg; 2006 Oct;35(10):961-4
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  • [Title] Floor of mouth haemorrhage and life-threatening airway obstruction during immediate implant placement in the anterior mandible.
  • [MeSH-major] Dental Implantation, Endosseous / adverse effects. Hematoma / etiology. Mandible / surgery. Mouth Floor / injuries. Oral Hemorrhage / etiology

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  • (PMID = 16829038.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Huang ZQ, Li JS, Chen WL, Pan CB, Huang HZ, Zeng WK: [Application of multislice spiral CT and 3D reconstruction in diagnosis and treatment of vascular malformations in head and neck]. Zhonghua Zheng Xing Wai Ke Za Zhi; 2009 Jan;25(1):28-31
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  • [Title] [Application of multislice spiral CT and 3D reconstruction in diagnosis and treatment of vascular malformations in head and neck].
  • OBJECTIVE: To explore the application of MS-CT and 3D reconstruction in diagnosis and treatment of vascular malformations in head and neck.
  • 12 cases of venous malformations in buccal and floor of mouth were treated with compartmentalized sclerotherapy with partial lesion involution.
  • 2 case of venous malformations in mouth floor were treated with operation followed by sclerotherpy with partial lesion involution.
  • CONCLUSION: MS-CT and 3D reconstruction can play an important role in diagnosis and treatment of vascular malformations in head and neck.

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  • (PMID = 19408721.001).
  • [ISSN] 1009-4598
  • [Journal-full-title] Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
  • [ISO-abbreviation] Zhonghua Zheng Xing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Shin EJ, Wanna GB, Choi B, Aguila D 3rd, Ebert O, Genden EM, Woo SL: Interleukin-12 expression enhances vesicular stomatitis virus oncolytic therapy in murine squamous cell carcinoma. Laryngoscope; 2007 Feb;117(2):210-4
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  • In vivo testing of multiple direct intratumoral injections of rVSV-F or rVSV-IL12 in an orthotopic floor of mouth murine model was performed.
  • In an SCC VII orthotopic floor of mouth model in immunocompetent C3H/HeJ mice, multiple intratumoral injections with each virus caused a significant reduction in tumor volume when compared with saline injections alone.
  • The rVSV-IL12-treated tumors showed a striking reduction in tumor volume when compared with rVSV-F and saline-treated tumors (P < .005).
  • This striking reduction in tumor volume translated into a substantial survival benefit in rVSV-IL12-treated animals.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Survival. Coloring Agents. Disease Models, Animal. Gene Expression Regulation, Viral. Gene Transfer Techniques. Injections, Intralesional. Mice. Mice, Inbred C3H. Mice, Inbred Strains. Mouth Floor / pathology. Mouth Neoplasms / therapy. RNA, Viral / analysis. RNA, Viral / genetics. Survival Rate. Tetrazolium Salts. Thiazoles. Virus Replication

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  • (PMID = 17204993.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / RNA, Viral; 0 / Tetrazolium Salts; 0 / Thiazoles; 187348-17-0 / Interleukin-12; 298-93-1 / thiazolyl blue
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22. Fuwa N, Kodaira T, Furutani K, Tachibana H, Nakamura T: A new method of selective intra-arterial infusion therapy via the superficial temporal artery for head and neck cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):783-9
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  • Primary tumor sites included the tongue in 73 patients, base of the tongue in 6 patients, floor of mouth in 4 patients, buccal mucosa in 4 patients, and other sites in 5 patients.

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  • (PMID = 18206406.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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23. Martins MD, Anunciato de Jesus L, Fernandes KP, Bussadori SK, Taghloubi SA, Martins MA: Intra-oral schwannoma: case report and literature review. Indian J Dent Res; 2009 Jan-Mar;20(1):121-5
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  • Schwannoma is a relatively uncommon, slow-growing benign tumor that is derived apparently from the Schwann cells.
  • The tongue is the most common site, followed by the palate, floor of mouth, buccal mucosa, lips, and jaws.
  • Usually, this lesion is not taken into account during clinical practice and the differential diagnosis includes numerous benign neoformations based on epithelial and connective tissues.
  • The diagnosis was established based on clinical, histopathological, and immunohistochemical aspects.
  • [MeSH-major] Mouth Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 19336874.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 23
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24. Wein RO, Lewis AF: Synchronous reconstruction of the floor of mouth and chin with a single skin island fibular free flap. Microsurgery; 2008;28(4):223-6
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  • [Title] Synchronous reconstruction of the floor of mouth and chin with a single skin island fibular free flap.
  • RESULTS: A 70-year old male with an anterior floor of mouth squamous cell carcinoma underwent composite resection that included resection of a 5-cm ovoid component of overlying chin skin.
  • [MeSH-major] Chin / surgery. Fibula / transplantation. Mouth Floor / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Aged. Humans. Male. Mandibular Neoplasms / secondary. Mandibular Neoplasms / surgery. Mouth Neoplasms / secondary. Mouth Neoplasms / surgery. Neoplasms, Squamous Cell / surgery. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / surgery

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  • [Copyright] (c) 2008 Wiley-Liss, Inc. Microsurgery, 2008
  • (PMID = 18335456.001).
  • [ISSN] 1098-2752
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Menezes MB, Lehn CN, Gonçalves AJ: Epidemiological and histopathological data and E-cadherin-like prognostic factors in early carcinomas of the tongue and floor of mouth. Oral Oncol; 2007 Aug;43(7):656-61
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  • [Title] Epidemiological and histopathological data and E-cadherin-like prognostic factors in early carcinomas of the tongue and floor of mouth.
  • Despite recent advances in diagnosis and treatment, overall survival of people with squamous cell carcinomas of the tongue and mouth floor continues to be low.
  • We searched for epidemiological and pathological behaviors that could be involved in tumor recurrence and the influence of cellular adhesion loss in patient outcome.
  • Significant prognostic variables included age, daily alcohol intake, neural invasion and maximum tumor thickness.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Age Factors. Alcohol Drinking / adverse effects. Female. Humans. Male. Mouth Floor / pathology. Mutation. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 17350325.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins
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26. White A, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD: Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet. Inflamm Bowel Dis; 2006 Jun;12(6):508-14
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  • BACKGROUND: Orofacial granulomatosis (OFG) is a chronic inflammatory disorder presenting characteristically with lip swelling but also affecting gingivae, buccal mucosa, floor of mouth, and a number of other sites in the oral cavity.
  • MATERIALS AND METHODS: Thirty-two patients with a confirmed diagnosis of OFG were identified from a combined oral medicine/gastroenterology clinic.
  • [MeSH-minor] Adult. Diet. Female. Humans. Lip / pathology. Male. Mouth / pathology. Patch Tests

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  • (PMID = 16775496.001).
  • [ISSN] 1078-0998
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzoates
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27. Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, Hunter KD, Sorensen JA, Thomsen J, Krogdahl A, Alvarez J, Barbier L, Santamaria J, Poli T, Sesenna E, Kovács AF, Grünwald F, Barzan L, Sulfaro S, Alberti F: Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European multicenter trial. Ann Surg Oncol; 2010 Sep;17(9):2459-64
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  • RESULTS: Sentinel nodes were successfully identified in 125 of 134 patients (93%), with a lower success rate observed for floor-of-mouth tumors (FoM; 88% vs. 96%, P = 0.138).
  • The sensitivity and negative predictive values (NPV) were lower for patients with FoM tumors compared with other sites (80% vs. 97% and 88% vs. 98%, respectively, P = 0.034).
  • It can be used as the sole staging tool for the majority of these patients, but cannot currently be recommended for patients with tumors in the floor of the mouth.

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  • (PMID = 20552410.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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28. Coughlin A, Resto VA: Oral cavity squamous cell carcinoma and the clinically n0 neck: the past, present, and future of sentinel lymph node biopsy. Curr Oncol Rep; 2010 Mar;12(2):129-35
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  • Limitations with floor-of-mouth primaries and delayed secondary SNDs have been described, but a new agent designed to address these shortcomings, Lymphoseek (Neoprobe Corp.

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  • (PMID = 20425598.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA132988-01A2; United States / NCI NIH HHS / CA / K08 CA132988; United States / NCI NIH HHS / CA / K08 CA132988-01A2
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
  • [Other-IDs] NLM/ NIHMS194964; NLM/ PMC2862587
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29. Jha AK, Prasiko G, Mod M, Srivastava R, Chaurasia PP: Curative interstitial brachytherapy for early stage carcinoma lip. JNMA J Nepal Med Assoc; 2006 Apr-Jun;45(162):252-7
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  • Brachytherapy is potentially useful in the treatment of head-and-neck cancers, because most tumor sites, such as the lip, tongue, floor of mouth, tonsil, pharynx, nasopharynx, sinuses, and neck, are accessible for the placement of afterloading applicators and catheters.
  • It has the advantage of delivering a higher radiation dose to the tumor while sparing surrounding normal tissue from radiation.
  • Furthermore, the overall treatment duration is shorter, and the dose distribution confirms to tumor shape.

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  • (PMID = 17189971.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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30. Xu GZ, Yang C, Yu CQ, He D, Zhang S: Multiple superficial mucoceles on lower lip, soft palate, retromolar region, and floor of mouth. J Oral Maxillofac Surg; 2010 Oct;68(10):2601-3
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  • [Title] Multiple superficial mucoceles on lower lip, soft palate, retromolar region, and floor of mouth.
  • [MeSH-major] Mouth Diseases / pathology. Mucocele / pathology

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  • (PMID = 20591556.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Zhang JH, Zhou ZT: [Oral lichen planus: a retrospective study of 724 Chinese patients]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Nov;42(11):669-71
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  • The buccal mucosa was the most common site of involvement in each form, followed by the dorsal tongue, ventral tongue, lip, gingiva, palate and the floor of mouth.

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  • (PMID = 18307924.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Jerjes W, Upile T, Petrie A, Riskalla A, Hamdoon Z, Vourvachis M, Karavidas K, Jay A, Sandison A, Thomas GJ, Kalavrezos N, Hopper C: Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head Neck Oncol; 2010;2:9
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  • In this retrospective analysis, clinicopathological parameters of 115 T1/T2 OSCC were studied and compared to recurrence and death from tumour-related causes.
  • Causes of death were collated in 4 categories (1) death from locoregional spread, (2) death from distant metastasis, (3) death from bronchopulmonary pneumonia, and (4) death from any non-tumour event that lead to cardiorespiratory failure.
  • Their mean age at the 1st diagnosis of OSCC was 61.7 years.
  • Primary sites were mainly identified in the tongue, floor of mouth (FOM), buccal mucosa and alveolus.
  • Tumour clearance was ultimately achieved in 107 patients.
  • The mean age of 1st diagnosis of the recurrence group was 59.53 years.
  • Most common oral sites included the lateral border of tongue and floor of mouth.
  • Tumour clearance was achieved in only 8 patients.
  • The mean depth of tumour invasion in the recurrence group was 7.6 mm.An interesting finding was that 5/11 patients who died of distant metastasis had their primary disease in the tongue.
  • All patients who died from locoregional and distant metastasis were shown to have recurrence after the primary tumour resection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20406474.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2882907
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33. Chen SL, Yu CC, Chang MC, Deng SC, Wu YS, Chen TM: Medial sural artery perforator flap for intraoral reconstruction following cancer ablation. Ann Plast Surg; 2008 Sep;61(3):274-9
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  • Between June 2003 and March 2007, 22 free medial sural artery perforator flaps were transferred for intraoral defects after cancer ablation, including tongue and floor of mouth (15 cases), buccal mucosa (5 cases), retromolar trigone (1 case), and anterior floor of mouth (1 case).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Female. Glossectomy / methods. Humans. Male. Middle Aged. Mouth Floor / surgery. Tongue / surgery. Treatment Outcome

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  • (PMID = 18724127.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Rosow DE, Ward RF, April MM: Sialodochostomy as treatment for imperforate submandibular duct: a systematic literature review and report of two cases. Int J Pediatr Otorhinolaryngol; 2009 Dec;73(12):1613-5
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  • OBJECTIVE: To better understand the diagnosis, treatments, and outcomes of congenitally imperforate salivary ducts.
  • Only papers focusing on congenital floor of mouth cysts arising from imperforate salivary ducts were included.
  • CONCLUSIONS: Congenital floor of mouth cysts arising from imperforate salivary ducts are rare, but they may mimic the appearance of a ranula.
  • Care should be taken to exclude ranula as a diagnosis, as incomplete excision may likely result in recurrence.
  • [MeSH-minor] Congenital Abnormalities / surgery. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Ranula / diagnosis. Ranula / surgery. Risk Assessment. Treatment Outcome

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  • (PMID = 19380165.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 17
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35. El-Hakim IE, Alyamani A: Alternative surgical approaches for excision of dermoid cyst of the floor of mouth. Int J Oral Maxillofac Surg; 2008 May;37(5):497-9
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  • [Title] Alternative surgical approaches for excision of dermoid cyst of the floor of mouth.
  • [MeSH-major] Dermoid Cyst / surgery. Mouth Floor / surgery. Mouth Neoplasms / surgery. Oral Surgical Procedures / methods

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  • (PMID = 18272345.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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36. Ikeda K, Koseki T, Maehara M, Ohmura N, Kurokawa H, Shimizutani K, Sawada S: Hourglass-shaped sublingual dermoid cyst: MRI features. Radiat Med; 2007 Jul;25(6):306-8
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  • Dermoid cysts located in the floor of the mouth are classified as submental or sublingual based on their location with respect to the mylohyoid muscle.
  • An hourglass-shaped cyst of the floor of mouth was seen.
  • [MeSH-major] Dermoid Cyst / diagnosis. Magnetic Resonance Imaging. Mouth Floor. Mouth Neoplasms / diagnosis

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37. Wilhelm T, Harlaar J, Kerver A, Kleinrensink GJ, Benhidjeb T: [Transoral endoscopic thyroidectomy. Part 1: rationale and anatomical studies]. Chirurg; 2010 Jan;81(1):50-5
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  • The investigation focused on relevant vascular and neural structures in the floor of mouth.
  • Thus based on anatomical dissections the foundations of a novel procedure in the context of natural orifice surgery (NOS) could be established.

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  • (PMID = 19940971.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
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  • [Publication-type] English Abstract; Journal Article
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38. Schwarz RA, Gao W, Redden Weber C, Kurachi C, Lee JJ, El-Naggar AK, Richards-Kortum R, Gillenwater AM: Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy. Cancer; 2009 Apr 15;115(8):1669-79
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  • BACKGROUND: Optical spectroscopy is a noninvasive technique with potential applications for diagnosis of oral dysplasia and early cancer.
  • Algorithms based on spectra from 310 nonkeratinized anatomic sites (buccal, tongue, floor of mouth, and lip) yielded an area under the receiver operating characteristic curve of 0.96 in the training set and 0.93 in the validation set.
  • For nonkeratinized oral sites, the sensitivity and specificity of this objective diagnostic technique were comparable to that of clinical diagnosis by expert observers.

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  • (PMID = 19170229.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095604-04; United States / NCI NIH HHS / CA / R01 CA095604; United States / NCI NIH HHS / CA / R01 CA095604-04; United States / NCI NIH HHS / CA / R01-CA095604
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS89224; NLM/ PMC2728679
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39. McGee S, Mardirossian V, Elackattu A, Mirkovic J, Pistey R, Gallagher G, Kabani S, Yu CC, Wang Z, Badizadegan K, Grillone G, Feld MS: Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy. Ann Otol Rhinol Laryngol; 2009 Nov;118(11):817-26
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  • OBJECTIVES: We used reflectance and fluorescence spectroscopy to noninvasively and quantitatively distinguish benign from dysplastic/malignant oral lesions.
  • RESULTS: Discrimination of benign from dysplastic/malignant lesions was most successful when algorithms were designed for individual sites (area under the receiver operator characteristic curve [ROC-AUC],0.75 for the lateral surface of the tongue) and was least accurate when all sites were combined (ROC-AUC, 0.60).
  • The combination of sites with similar spectral properties (floor of mouth and lateral surface of the tongue) yielded an ROC-AUC of 0.71.
  • Anatomy-based algorithms for single sites or combinations of sites demonstrated good diagnostic performance in distinguishing benign lesions from dysplastic/malignant lesions and consistently performed better than algorithms developed for all sites combined.

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  • (PMID = 19999369.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA097966-05; United States / NCI NIH HHS / CA / R01-CA097966; United States / NCI NIH HHS / CA / R01 CA097966-05; United States / NCI NIH HHS / CA / R01 CA097966; United States / NCRR NIH HHS / RR / P41 RR002594; United States / NCRR NIH HHS / RR / P41 RR002594-24
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS189378; NLM/ PMC2860948
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40. Xavier FC, Rocha AC, Sugaya NN, dos Santos-Pinto D Jr, de Sousa SC: Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor. Med Oral Patol Oral Cir Bucal; 2009 Dec;14(12):e635-9
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  • [Title] Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor.
  • Inflammatory myofibroblastic tumor is a distinctive lesion composed of myofibroblastic spindle shaped cells accompanied by inflammatory infiltrate that may arise in various organs.
  • The recognition of inflammatory myofibroblastic tumor as an entity is important especially to avoid unnecessary surgery.
  • This report primarily presents a case of inflammatory myofibroblastic tumor that arose in the floor of mouth of a 23-year-old woman.
  • Also, the presence of well differentiated myofibroblasts identified by fibronectin is discussed, as well as the importance in establishing an immunoprofile to better consolidate the diagnosis.
  • We conclude that the study of fibronectin in case series may aid the diagnosis as well as the prediction of the tumor course.
  • [MeSH-major] Fibronectins / analysis. Mouth Neoplasms / chemistry. Mouth Neoplasms / pathology

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  • (PMID = 19680189.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fibronectins
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41. Joshi A, Rajendraprasad JS, Shetty K: Reconstruction of intraoral defects using facial artery musculomucosal flap. Br J Plast Surg; 2005 Dec;58(8):1061-6
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  • The facial artery musculomucosal flap, technically a combination of the nasolabial flap and the buccal mucosal flap, has been a reliable, versatile flap, either superiorly or inferiorly based for reconstruction of a wide variety of postcancer excision intraoral mucosal defects including defects of the palate, alveolus, lips and floor of mouth.
  • [MeSH-major] Mouth / surgery. Mouth Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Aged. Alveolar Process / surgery. Arteries. Child. Face / blood supply. Humans. Lip / surgery. Male. Middle Aged. Mouth Floor / surgery. Mouth Mucosa / surgery. Palate / surgery. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 16099439.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Squier CA, Mantz MJ, Wertz PW: Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo. Nicotine Tob Res; 2010 Jul;12(7):763-7
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  • As oral mucosa is exposed to both smoke and smokeless tobacco in tobacco users, the objective of this study was to determine whether menthol influenced the penetration of the TC nitrosonornicotine (NNN) across porcine buccal (BM) and floor of mouth (FM) mucosa.
  • [MeSH-major] Carcinogens / pharmacology. Central Nervous System Depressants / pharmacology. Menthol / pharmacology. Mouth Mucosa / metabolism. Nitrosamines / pharmacology. Tobacco / chemistry

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  • (PMID = 20511349.001).
  • [ISSN] 1469-994X
  • [Journal-full-title] Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • [ISO-abbreviation] Nicotine Tob. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Central Nervous System Depressants; 0 / Nitrosamines; 1490-04-6 / Menthol; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
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43. Ogbureke KU, Nikitakis NG, Warburton G, Ord RA, Sauk JJ, Waller JL, Fisher LW: Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer. Oral Oncol; 2007 Oct;43(9):920-32
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  • Various combinations of the SIBLING family of proteins have been found to be up-regulated in many human cancers and have been linked to different stages of tumor progression, including metastasis.
  • There were no correlations between SIBLING expression and tumor size ("T"; of the Union Internationale Contre le Cancer [UICC]-TNM classification for OSCC), and between SIBLING expression and lymph node spread for the T1/T2 tumors.
  • The levels of DSPP expression for floor of mouth and retromolar region tumors were higher than for tongue tumors.
  • While the production of these SIBLINGs is independent of T, they correlate with oral location of tumor, cognate MMP expression, and for DSPP, the degree of tumor differentiation.
  • [MeSH-major] Carcinoma, Squamous Cell / chemistry. Matrix Metalloproteinases / analysis. Mouth Neoplasms / chemistry. Sialoglycoproteins / metabolism. Up-Regulation
  • [MeSH-minor] Aged. Aged, 80 and over. Chi-Square Distribution. Extracellular Matrix Proteins / analysis. Extracellular Matrix Proteins / metabolism. Female. Humans. Immunohistochemistry. Integrin-Binding Sialoprotein. Male. Matrix Metalloproteinase 2 / analysis. Matrix Metalloproteinase 3 / analysis. Matrix Metalloproteinase 9 / analysis. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Osteopontin / analysis. Osteopontin / metabolism. Phosphoproteins

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  • (PMID = 17306612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / IBSP protein, human; 0 / Integrin-Binding Sialoprotein; 0 / Neoplasm Proteins; 0 / Phosphoproteins; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein; 106441-73-0 / Osteopontin; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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44. McCullough MJ, Abdel-Hafeth S, Scully C: Recurrent aphthous stomatitis revisited; clinical features, associations, and new association with infant feeding practices? J Oral Pathol Med; 2007 Nov;36(10):615-20
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  • RESULTS: Patients with a clinical diagnosis of RAS were significantly more often males (P = 0.001) younger (P < 0.001).
  • Significant correlations were observed between a diagnosis of RAS and trauma (P = 0.044), stress (P = 0.006), non-smoking (P < 0.001), a family history (P < 0.001), breast feeding (P = 0.017) and the site in the mouth (buccal, labial, floor of mouth) (P < 0.007).
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Aged. Aged, 80 and over. Breast Feeding / adverse effects. Child. Child, Preschool. Facial Injuries / complications. Female. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Retrospective Studies. Sex Ratio. Smoking. Stress, Psychological / complications

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  • (PMID = 17944755.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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45. Chong V: Oral cavity cancer. Cancer Imaging; 2005;5 Spec No A:S49-52
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  • Imaging information is essential for determining tumour resectibility, post resection surgical reconstruction and radiation therapy planning.
  • It focuses on buccal mucosa, hard palate, tongue and floor of mouth carcinoma.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed

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  • [Copyright] International Cancer Imaging Society.
  • [Cites] Head Neck. 1997 May;19(3):205-10 [9142520.001]
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  • (PMID = 16361136.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1665311
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46. Civantos F, Zitsch R, Bared A: Sentinel node biopsy in oral squamous cell carcinoma. J Surg Oncol; 2007 Sep 15;96(4):330-6
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  • Preliminary data indicate that it may be useful for early oral cancers, with the exception of floor of mouth tumors, where technical challenges related to the proximity of the lymphatic basin remain a problem.
  • While central step sectioning and immunohistochemistry remain to be completed and analyzed, routine pathologic techniques provided negative predictive values of 96% for oral cancer excluding floor of mouth lesions.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neck Dissection. Sentinel Lymph Node Biopsy / methods
  • [MeSH-minor] Clinical Trials as Topic. Drainage. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Neoplasm Staging. Predictive Value of Tests. Radioimmunodetection. Risk Factors


47. Coutinho-Camillo CM, Lourenço SV, Nishimoto IN, Kowalski LP, Soares FA: Expression of Bcl-2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma. Histopathology; 2010 Aug;57(2):304-16
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  • Increased expression of the Bcl-2-related protein and PUMA was associated with tumours occurring in the floor of mouth and increased expression of PUMA was also associated with recurrence of the tumour.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / metabolism. Mouth Neoplasms / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism

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  • (PMID = 20716171.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BAK1 protein, human; 0 / BAX protein, human; 0 / BBC3 protein, human; 0 / BCL2-associated athanogene 1 protein; 0 / BCL2-related protein A1; 0 / BCL2L1 protein, human; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Bcl-2-like protein 11; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Transcription Factors; 0 / bcl-2 Homologous Antagonist-Killer Protein; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein
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48. Zhang C, Zhang Z, Qiu W, Lin G, Lan H, Tang Y, Sun J, Shen G, Hu Y, Ye W, Li J, Ji T, Xu L: [Repair and reconstruction of oral and maxillofacial defect--clinical analysis of 1973 cases]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2005 Oct;19(10):773-6
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  • The ratio of benign to malignancy lesion was 1 : 1.94.
  • The tongue defect accounted for 20.63%, followed by mandibular defect(17.38%), parotid defect(13.74%), buccal defect(12.72%), maxillary defect (8.16%), oral pharynx defect (7.60%), floor of mouth defect (5.68%) and others (14.09%).

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  • (PMID = 16274120.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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49. Hamadah O, Thomson PJ: Factors affecting carbon dioxide laser treatment for oral precancer: a patient cohort study. Lasers Surg Med; 2009 Jan;41(1):17-25
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  • The majority of lesions were leukoplakias arising in the floor of mouth and ventro-lateral tongue and moderate or severe dysplasia accounted for 86% of histopathological diagnoses.
  • [MeSH-major] Lasers, Gas / therapeutic use. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Risk Factors. Socioeconomic Factors. Survival Rate. Treatment Outcome

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  • (PMID = 19143013.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Rogers SN, Pabla R, McSorley A, Lowe D, Brown JS, Vaughan ED: An assessment of deprivation as a factor in the delays in presentation, diagnosis and treatment in patients with oral and oropharyngeal squamous cell carcinoma. Oral Oncol; 2007 Aug;43(7):648-55
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  • [Title] An assessment of deprivation as a factor in the delays in presentation, diagnosis and treatment in patients with oral and oropharyngeal squamous cell carcinoma.
  • Patients with shorter duration of symptoms tended to be smokers, drinkers, with lower gum and floor of mouth tumours, and more advanced disease.
  • There was on average about 3 weeks from referral to definitive diagnosis and about another 3 weeks before having surgery.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis. Oropharyngeal Neoplasms / diagnosis. Psychosocial Deprivation. Referral and Consultation


51. Durazzo MD, de Araujo CE, Brandão Neto Jde S, Potenza Ade S, Costa P, Takeda F, Bianchi C, Tavares MR, de Britto e Silva Filho G, Ferraz AR: Clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. Clinics (Sao Paulo); 2005 Aug;60(4):293-8
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  • A majority had tumors of the tongue and/or floor of mouth (55.6%), while 20.3% had lip cancer.
  • [MeSH-major] Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brazil / epidemiology. Female. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / secondary. Hospitals, Teaching. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16138235.001).
  • [ISSN] 1807-5932
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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52. Donepudi SK, Stocks RM, Pivnick EK, Mineck C, Thompson JW: Cleft palate lateral synechia syndrome: an opportunity for unique surgical closure. Int J Pediatr Otorhinolaryngol; 2009 Jun;73(6):861-6
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  • Mucosa-lined, fibromuscular tissue bands were noted connecting the floor of mouth and the free edges of a bilateral complete secondary cleft palate.
  • Genetic analysis failed to reveal chromosomal defects or a mutation in the interferon regulatory factor 6 (IRF6) gene, a locus linked to Van der Woude syndrome.


53. Tse GM, Chan AW, Yu KH, King AD, Wong KT, Chen GG, Tsang RK, Chan AB: Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma. Ann Surg Oncol; 2007 Dec;14(12):3558-65
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  • BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) has high morbidity and mortality, and its relationship with tumor angiogenesis as measured by microvessel density (MVD) or vascular endothelial growth factor (VEGF) expression has shown mixed results, with some, but not others, reporting correlation with outcome.
  • Patients were evaluated for MVD and VEGF and to correlate the levels with clinical parameters, including age at diagnosis, sex, site of tumor, stage, survival (disease free and overall), pathological tumor grade, and the presence of lymph node metastases.
  • RESULTS: The 186 cancers included the following sites: oral tongue (n = 69), palate (n = 9), maxillary sinus (n = 8), floor of mouth (n = 13), oropharynx (n = 27), hypopharynx (n = 26) and larynx (n = 34).
  • Over three-quarters of patients had advanced tumor (stage III/IV) and 58.6% had lymph node metastases.
  • [MeSH-minor] Female. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Neovascularization, Pathologic. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17929099.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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54. Merkx MA, van Gulick JJ, Marres HA, Kaanders JH, Bruaset I, Verbeek A, de Wilde PC: Effectiveness of routine follow-up of patients treated for T1-2N0 oral squamous cell carcinomas of the floor of mouth and tongue. Head Neck; 2006 Jan;28(1):1-7
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  • [Title] Effectiveness of routine follow-up of patients treated for T1-2N0 oral squamous cell carcinomas of the floor of mouth and tongue.
  • The purpose of this study was to determine the benefit of our 10-year follow-up program in patients with stage I and II squamous cell carcinoma (SCC) of the floor of mouth and tongue.
  • METHODS: In a longitudinal cohort study involving 102 patients who were treated with curative intent for a pT1-2N0M0 SCC of the floor of mouth and tongue from 1989-1998 with a minimum follow-up of 5 years, we evaluated the effect of routine follow-up.
  • RESULTS: During the follow-up (mean, 61 months; SD, 4 months), 10 patients had a recurrence, and 20 patients had a second primary tumor.
  • Location, T classification of the primary tumor, choice of therapy, or measure of tumor-free margins in the resection did not significantly affect the occurrence of a secondary event (p >or= .1).
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Mouth Neoplasms / therapy. Neoplasm Recurrence, Local / therapy. Neoplasms, Second Primary / therapy
  • [MeSH-minor] Cohort Studies. Disease-Free Survival. Female. Humans. Longitudinal Studies. Male. Middle Aged. Mouth Floor. Retrospective Studies. Time Factors. Tongue Neoplasms / diagnosis. Tongue Neoplasms / therapy. Treatment Outcome

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc. Head Neck 27: XXX-XXX, 2005.
  • (PMID = 16155911.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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55. Marimo C: Epidemiology of oral Kaposi's sarcoma in Zimbabwe 1988-1997: a population-based study. Cent Afr J Med; 2008 Jan-Apr;54(1-4):15-9
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  • A total of 445 incident cases of OKS from the upper and lower lips, oral vestibule, retromolar area, floor of mouth, tongue, cheek, mucosa, gums, hard and soft palate were accessed from the Zimbabwe National Cancer Registry (ZNCR).
  • Histology of the primary (64.5%) and clinical diagnosis (34.6%) were the predominant methods of diagnosis.
  • OKS mostly affected the palate (70.2%) followed by, in descending order, the tongue (13.3%) and mouth (8.3%).
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Mouth Neoplasms / epidemiology. Sarcoma, Kaposi / epidemiology

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  • (PMID = 21644423.001).
  • [ISSN] 0008-9176
  • [Journal-full-title] The Central African journal of medicine
  • [ISO-abbreviation] Cent Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Zimbabwe
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56. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Mora Santos ME, Barrantes Celaya G, Blasco Huelva A: [Phlegmons and abscesses in the floor of mouth. Report of 10 cases and review of the literature]. An Otorrinolaringol Ibero Am; 2006;33(6):599-606
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  • [Title] [Phlegmons and abscesses in the floor of mouth. Report of 10 cases and review of the literature].
  • [Transliterated title] Flemones y abscesos del suelo de boca. Análisis de 10 casos y revisión de la literatura.
  • We report a review about 10 cases of phlegmons-abscesses in the floor of mouth (Ludwig's angina) treated by our Service analyzing the following variables: Age, sex, time of evolution, personal antecedents, E.N.T. exploration, clinical symptoms, type of treatment and clinical evolution.
  • This pathology represents one of the most severe forms of cervicofacial diffuse cellulitis; it requires an early diagnosis and therapy which can include an urgent tracheostomy ifthe airway is compromised.
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Drainage / methods. Female. Humans. Male. Middle Aged. Mouth Floor / microbiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 17233275.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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57. Palmer PM, Jaffe DM, McCulloch TM, Finnegan EM, Van Daele DJ, Luschei ES: Quantitative contributions of the muscles of the tongue, floor-of-mouth, jaw, and velum to tongue-to-palate pressure generation. J Speech Lang Hear Res; 2008 Aug;51(4):828-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitative contributions of the muscles of the tongue, floor-of-mouth, jaw, and velum to tongue-to-palate pressure generation.
  • Activation of the floor-of-mouth, tongue, and jaw closing muscles increased tongue-to-palate pressure.
  • These findings support the use of a tongue-press exercise to strengthen floor-of-mouth muscles, tongue, and jaw-closing muscles.
  • [MeSH-major] Mandible / physiology. Mouth Floor / physiology. Muscle, Skeletal / physiology. Palate, Soft / physiology. Pressure. Tongue / physiology

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  • (PMID = 18658054.001).
  • [ISSN] 1092-4388
  • [Journal-full-title] Journal of speech, language, and hearing research : JSLHR
  • [ISO-abbreviation] J. Speech Lang. Hear. Res.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / DC 00040; United States / NIDCD NIH HHS / DC / P60-DC00976
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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58. Stuck BA, Abrams J, de la Chaux R, Dreher A, Heiser C, Hohenhorst W, Kühnel T, Maurer JT, Pirsig W, Steffen A, Verse T, ArGe Schlafmedizin der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V: [S1 guideline on the "diagnosis and treatment of snoring in adults"]. HNO; 2010 Mar;58(3):272-8
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  • [Title] [S1 guideline on the "diagnosis and treatment of snoring in adults"].
  • [Transliterated title] S1-Leitlinie "Diagnostik und Therapie des Schnarchens des Erwachsenen".
  • Due to the frequency of this phenomenon and the often considerable distress caused to the affected person, competent advice, diagnosis and treatment of snoring in adults is of particular importance.
  • Since evidence for the effectiveness of muscle stimulation or various methods for toning and training of the muscles of the floor of mouth is not available, these methods are not recommended.
  • [MeSH-major] Otolaryngology / standards. Snoring / diagnosis. Snoring / prevention & control

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  • (PMID = 20204310.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Practice Guideline
  • [Publication-country] Germany
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59. Takashima S, Nakano H, Misao T: [True thymic hyperplasia which was difficult to distinguish from malignancy in adult; report of a case]. Kyobu Geka; 2008 Jul;61(7):599-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three years earlier he had undergone operation for carcinoma of the floor of mouth.
  • [MeSH-major] Thymus Gland / pathology. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 18616111.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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60. Chen SL, Chen TM, Dai NT, Hsia YJ, Lin YS: Medial sural artery perforator flap for tongue and floor of mouth reconstruction. Head Neck; 2008 Mar;30(3):351-7
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  • [Title] Medial sural artery perforator flap for tongue and floor of mouth reconstruction.
  • METHODS: We used 12 medial sural artery perforator flaps to reconstruct tongue and floor of mouth following cancer ablation.
  • [MeSH-major] Mouth Floor / surgery. Surgical Flaps / blood supply. Tongue / surgery

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 17972307.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Shrime MG, Gullane PJ, Dawson L, Kim J, Gilbert RW, Irish JC, Brown DH, Goldstein DP: The impact of adjuvant radiotherapy on survival in T1-2N1 squamous cell carcinoma of the oral cavity. Arch Otolaryngol Head Neck Surg; 2010 Mar;136(3):225-8
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  • Adjuvant RT improved survival in patients with T2 tongue and floor of mouth disease (52.3% vs 37.9% [P = .002] and 39.9% vs 17.7% [P = .003], respectively).
  • CONCLUSION: In cases involving T1-2N1 OCSCC in the Surveillance, Epidemiology, and End Results database, the use of RT is associated with statistically significant improved overall survival and cause-specific survival in patients with T2 disease, most strongly in the oral tongue and the floor of the mouth.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Mouth Neoplasms / mortality. Mouth Neoplasms / radiotherapy


62. Aarts MC, Hogen Esch TT, Terhaard CH, Koole R, Hordijk GJ: Guidelines in head and neck oncology compliance and consequences of deviations from the standard protocol for tongue and floor of mouth squamous carcinoma. Clin Otolaryngol; 2005 Oct;30(5):444-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Guidelines in head and neck oncology compliance and consequences of deviations from the standard protocol for tongue and floor of mouth squamous carcinoma.
  • OBJECTIVES: To investigate the extent of violation of a regional guideline for the treatment of patients with carcinoma of the tongue/floor of mouth (ICD0 C02, C04).
  • PARTICIPANTS: A total of 217 patients treated between 1991 and 2001 for a stage II and stage III carcinoma of the tongue/floor of mouth.
  • MAIN OUTCOME MEASURES: Protocol violation, tumour recurrence.
  • There was no statistically significant difference in tumour recurrence between the two groups for stage II (P=0.68) or stage III (P=0.97) disease, or between undertreatment and overtreatment of patients with stage II (P=0.47) or stage III (P=0.90) disease.
  • CONCLUSIONS: Although protocol violation occurs in as many as 45% of patients, this does not result in a worse tumour recurrence.
  • Neither overtreatment nor undertreatment appears to affect the overall tumour recurrence.
  • [MeSH-major] Mouth Neoplasms / therapy. Tongue Neoplasms / therapy
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Mouth Floor. Practice Guidelines as Topic. Retrospective Studies. Treatment Outcome

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  • (PMID = 16232249.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. David D, Clayman L, Saleh H: Value of fine-needle aspiration biopsy in initial evaluation of floor of the mouth masses: report of a case of low-grade mucoepidermoid carcinoma. Diagn Cytopathol; 2010 Feb;38(2):81-4
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  • [Title] Value of fine-needle aspiration biopsy in initial evaluation of floor of the mouth masses: report of a case of low-grade mucoepidermoid carcinoma.
  • Low-grade mucoepidermoid carcinoma (LG MEC) is a rare tumor which can occur in the minor salivary glands as intraoral lesion, more frequently in the palate and very rarely in the floor of the mouth.
  • Traditionally, the diagnosis has been made on surgical resection specimens only.
  • In this article, we report a case of LG MEC of the floor of mouth diagnosed by FNA and confirmed by subsequent surgical resection.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Mouth Neoplasms / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged. Salivary Glands, Minor / pathology. Sialadenitis / pathology


64. Bernhard MK, Hückel D, Hamala D: [Congenital ranula in a newborn]. HNO; 2007 May;55(5):388-91
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  • [Transliterated title] Sublinguale, livide Schwellung am Mundboden eines Neugeborenen: Kongenitale Ranula.
  • Ranulas are cystic lesions in the floor of the mouth.
  • We report the case of a premature newborn with a congenital ranula in the floor of mouth.
  • [MeSH-major] Ranula / congenital. Ranula / diagnosis. Salivary Gland Diseases / congenital. Salivary Gland Diseases / diagnosis. Sublingual Gland / pathology

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  • (PMID = 16770600.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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65. Badakhshi H, Marnitz S, Scherer H, Budach V, Haisch A: [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences]. HNO; 2008 Mar;56(3):328-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adenoidzystisches Karzinom des Oropharynx. Brachytherapie zur Behandlung eines lokalen Rezidivs.
  • MATERIAL AND METHODS: A 44 year old woman with the diagnosis of adenoid cystic carcinoma of the oropharynx and simultaneous pulmonary metastases received a mixed beam photon radiotherapy and a neutron boost.
  • A local recurrence in the base of tongue and floor of mouth was histologically confirmed.
  • Under general anaesthesia, eight needles were implanted into the palpable tumour.
  • On the basis of a pretreatment MRI, a single dose of 5 Gy encompassing the palpable tumour was given to a total dose of 15 Gy.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Adenoid Cystic / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Oropharyngeal Neoplasms / radiotherapy

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  • (PMID = 18288466.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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66. Schubert MM, Eduardo FP, Guthrie KA, Franquin JC, Bensadoun RJ, Migliorati CA, Lloid CM, Eduardo CP, Walter NF, Marques MM, Hamdi M: A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation. Support Care Cancer; 2007 Oct;15(10):1145-54
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  • All active laser treatment patients received daily direct laser treatment to the lower labial mucosa, right and left buccal mucosa, lateral and ventral surfaces of the tongue, and floor of mouth with energy densities of 2 J/cm2.

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  • (PMID = 17393191.001).
  • [ISSN] 0941-4355
  • [Journal-full-title] Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
  • [ISO-abbreviation] Support Care Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
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67. Byeon HK, Lim YC, Koo BS, Choi EC: Metastasis to the submandibular gland in oral cavity squamous cell carcinomas: pathologic analysis. Acta Otolaryngol; 2009 Jan;129(1):96-100
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  • Both these two cases had direct extension from a primary lesion (retromolar trigone and floor of mouth) and no submandibular glands showed pathologic evidence of isolated metastasis or local extension of metastatic lymph nodes.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Mouth Neoplasms / pathology. Submandibular Gland Neoplasms / secondary
  • [MeSH-minor] Humans. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging. Submandibular Gland / pathology. Submandibular Gland / surgery

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  • (PMID = 18607927.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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68. Arosarena OA, Madsen M, Haug R: Special considerations with floor of mouth and tongue cancer. Oral Maxillofac Surg Clin North Am; 2006 Nov;18(4):521-31
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  • [Title] Special considerations with floor of mouth and tongue cancer.

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  • (PMID = 18088850.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Kruse A, Grätz KW: Evaluation of metastases in the submandibular gland in head and neck malignancy. J Craniofac Surg; 2009 Nov;20(6):2024-7
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  • RESULTS: : Twenty-three patients (17.7%) revealed some type of pathology in the submandibular gland such as chronic sialadenitis (15), atrophy (5), tumor infiltration (5), and intraglandular lymph node (1).
  • Of the sialadenitis group, 9 of 12 patients had the primary tumor in the lower jaw, floor of mouth, or tongue.
  • The excision of the submandibular gland should be performed in cases with positive lymph nodes at level I and in tumor sites with a high risk of occult metastasis at level I.
  • [MeSH-minor] Cranial Irradiation / adverse effects. Female. Humans. Lymphatic Metastasis. Male. Mandibular Neoplasms / pathology. Middle Aged. Mouth Floor / pathology. Neck Dissection. Oral Surgical Procedures / adverse effects. Oropharyngeal Neoplasms / pathology. Retrospective Studies. Sialadenitis / etiology. Tongue Neoplasms / pathology

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  • (PMID = 19881371.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Virk RS, Panda N, Ghosh S: Mylohyoid cysticercosis: a rare submandibular mass. Ear Nose Throat J; 2009 Nov;88(11):1218-20
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  • Although skeletal muscle commonly harbors the cysticerci, we report a case in which they had infested the mylohyoid muscle in the floor of mouth, a site that has not been mentioned previously in the literature.
  • [MeSH-major] Cysticercosis / diagnosis. Neck Muscles / parasitology. Submandibular Gland / pathology. Submandibular Gland Diseases / parasitology

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  • (PMID = 19924665.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiprotozoal Agents; F4216019LN / Albendazole
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71. Szudek J, Taylor SM: Systematic review of the platysma myocutaneous flap for head and neck reconstruction. Arch Otolaryngol Head Neck Surg; 2007 Jul;133(7):655-61
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  • Logistic regression models were used to quantify the associations between preoperative factors (age, sex, T stage, prior radiation therapy, and recipient site) and complications (skin loss or necrosis, fistula, dehiscence, hematoma, and infection) at different recipient sites (floor of mouth, alveolar ridge, pharyngeal wall, buccal mucosa, tongue or tongue base, and tonsil).
  • Postoperative complications were not associated with age or sex but were associated with recipient site and tumor stage.
  • CONCLUSIONS: Postoperative complications were not associated with age, sex, or preoperative radiation therapy, but they were associated with recipient site and tumor stage.
  • [MeSH-minor] Fistula / etiology. Hematoma / etiology. Humans. Logistic Models. Mouth. Necrosis. Reoperation / statistics & numerical data. Skin / pathology

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  • (PMID = 17638777.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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72. Sung CK, Choi B, Wanna G, Genden EM, Woo SL, Shin EJ: Combined VSV oncolytic virus and chemotherapy for squamous cell carcinoma. Laryngoscope; 2008 Feb;118(2):237-42
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  • OBJECTIVES: Vesicular stomatitis virus (VSV) is a negative-strand ribonucleic acid (RNA) virus that replicates specifically in tumor cells and has oncolytic effects in a variety of malignant tumors.
  • In an orthotopic floor of mouth murine SCC model, intratumoral injections of virus combined with systemic cisplatin were tested for tumor control and animal survival.
  • RESULTS: In vitro, virus and cisplatin combination demonstrated rapid replication and enhanced tumor cell kill.
  • In vivo, combined rVSV-F with cisplatin reduced tumor burden and improved survival (P = .2 for both), while rVSV-IL12 monotherapy had better tumor control (P = .06) and survival (P = .024) than combination therapy.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cisplatin / therapeutic use. Combined Modality Therapy. Disease Models, Animal. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Head and Neck Neoplasms / virology. Membrane Glycoproteins. Mice. Mice, Inbred C3H. Mouth Floor / pathology. Mouth Floor / virology. Polymerase Chain Reaction. RNA, Viral / genetics. Recombinant Fusion Proteins. Survival Rate. Viral Envelope Proteins

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  • (PMID = 18043494.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / G protein, vesicular stomatitis virus; 0 / Membrane Glycoproteins; 0 / RNA, Viral; 0 / Recombinant Fusion Proteins; 0 / Viral Envelope Proteins; 0 / Viral Fusion Proteins; 187348-17-0 / Interleukin-12; Q20Q21Q62J / Cisplatin
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73. Razfar A, Walvekar RR, Melkane A, Johnson JT, Myers EN: Incidence and patterns of regional metastasis in early oral squamous cell cancers: feasibility of submandibular gland preservation. Head Neck; 2009 Dec;31(12):1619-23
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  • One patient with an advanced floor of mouth cancer had obvious infiltration of the SMG.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Mouth Neoplasms / pathology. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Cohort Studies. Combined Modality Therapy. Early Detection of Cancer. Feasibility Studies. Female. Humans. Incidence. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness / pathology. Neoplasm Staging. Probability. Prognosis. Retrospective Studies. Risk Assessment. Submandibular Gland / pathology. Submandibular Gland / surgery. Survival Analysis. Young Adult

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  • (PMID = 19475546.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Davis PL 3rd, Gibson KG, Evans AK: Foregut duplication cysts in siblings: A case report. Int J Pediatr Otorhinolaryngol; 2010 Nov;74(11):1331-4
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  • In this case, we report a case of two siblings with foregut duplication cysts-one cyst occurring in the floor of mouth and the other occurring in the thorax as an esophageal duplication.
  • [MeSH-major] Cysts / diagnosis. Esophageal Diseases / diagnosis. Mouth Diseases / diagnosis. Siblings
  • [MeSH-minor] Barium Sulfate. Child, Preschool. Contrast Media. Esophagogastric Junction / radiography. Humans. Infant, Newborn. Male. Mouth Floor / radiography. Mouth Floor / surgery. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20837366.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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75. Bajaj DR, Khoso NA, Devrajani BR, Matlani BL, Lohana P: Oral lichen planus: a clinical study. J Coll Physicians Surg Pak; 2010 Mar;20(3):154-7
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  • Biopsy was taken when the diagnosis was doubtful or malignancy was suspected.
  • Other sites involved were tongue (n=20), lips (n=28), palate (n=9) and floor of mouth (n=03).
  • [MeSH-major] Lichen Planus, Oral / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Risk Factors. Stress, Psychological. Young Adult

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  • (PMID = 20392375.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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76. Weijers M, Snow GB, Bezemer PD, van der Waal I: Malignancy grading is no better than conventional histopathological grading in small squamous cell carcinoma of tongue and floor of mouth: retrospective study in 128 patients. J Oral Pathol Med; 2009 Apr;38(4):343-7
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  • [Title] Malignancy grading is no better than conventional histopathological grading in small squamous cell carcinoma of tongue and floor of mouth: retrospective study in 128 patients.
  • In a retrospective study on 128 previously untreated patients with a T1 or T2 squamous cell carcinoma of the tongue and the floor of the mouth, the value of the classical Broders' grading system and the malignancy grading system were compared with regard to various outcome measures such as regional metastasis, local recurrence and 5-year survival.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Mouth Floor / pathology. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasms, Second Primary. Prognosis. Retrospective Studies. Tongue Neoplasms / classification. Tongue Neoplasms / pathology

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  • (PMID = 19222711.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Denmark
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77. Zhong LP, Zhou XJ, Wei KJ, Yang X, Ma CY, Zhang CP, Zhang ZY: [Application of serum tumor markers and support vector machine in the diagnosis of oral squamous cell carcinoma]. Shanghai Kou Qiang Yi Xue; 2008 Oct;17(5):457-60
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  • [Title] [Application of serum tumor markers and support vector machine in the diagnosis of oral squamous cell carcinoma].
  • PURPOSE: To investigate the clinical application value of serum tumor markers detection combined with support vector machine (SVM) model in the diagnosis of oral squamous cell carcinoma.
  • All the data was analyzed with SVM; the SVM models for diagnosis of oral squamous cell carcinoma were created, trained and validated by cross validation.
  • RESULTS: Among the 163 oral squamous cell carcinoma patients, there were 128 males and 35 females with the male-to-female ratio of 3.66:1; the age ranged from 30 to 85 years old with a mean age of 59.3 years old; according to the primary site of tumor, 72 cases in tongue, 34 in gingiva, 22 in buccal mucosa, 15 in palatal mucosa, 13 in floor of mouth, 4 in lip and 3 in retromolar region; according to the TNM-UICC classification, there were 33 patients at stage T1, 72 at T2, 44 at T3, 14 at T4, 119 at N0, 42 at N1, 2 at N2, 159 at M0, 4 at M1, 27 at clinical stage I, 51 at stage II, 52 at III, and 33 at IV; according to the pathological differentiation grade, 109 tumors were well differentiated, 42 were moderately differentiated and 12 were poorly differentiated.
  • Five serum tumor markers of CA211, CA199, TPA, CA724 and NSE were selected optimally to create the optimal SVM model for diagnosis of oral squamous cell carcinoma.
  • CONCLUSION: From the results, SVM model combined with 5 optimal serum tumor markers is suggested to be used in the diagnosis of oral squamous cell carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis. Support Vector Machine
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Tumor-Associated, Carbohydrate. Carcinoembryonic Antigen. Female. Humans. Keratins. Lung Neoplasms. Male. Middle Aged. Phosphopyruvate Hydratase. Sensitivity and Specificity

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  • (PMID = 18989582.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA 242 antigen; 0 / CA-72-4 antigen; 0 / Carcinoembryonic Antigen; 68238-35-7 / Keratins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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78. Figueiredo ML, Kim Y, St John MA, Wong DT: p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin Cancer Res; 2005 May 15;11(10):3939-48
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  • [Title] p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer.
  • EXPERIMENTAL DESIGN: We addressed the effect of p12 expression on tumor growth by using a well-established squamous cell carcinoma VII/SF floor of mouth xenograft mouse model.
  • The effect of therapy on tumor growth was determined for: (a) no treatment, (b) PBS, (c) vehicle (1,2-dioleoyloxy-3-trimethylammonium propane:cholesterol liposomes / 5% dextrose), (d) empty vector controls, and (e) p12-encoding vector experimental groups.
  • RESULTS: p12 gene therapy significantly induced antitumor effects as compared with controls, including (a) size and weight of p12-treated tumors decreased by 51% to 72% compared with all controls (P < 0.02), (b) tumor growth rate post-therapy was inhibited by 55% to 64% compared with empty vector controls (P < 0.0001), and (c) p12 expression was higher in p12-treated than controls (P < 0.002) by two-tailed t test analyses.
  • These results support a role for p12 as a novel tumor growth suppressor gene therapy and suggest that optimization and/or combination with current therapies may hold considerable promise in preparation for clinical trials.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Genetic Therapy. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / pharmacology

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  • (PMID = 15897596.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01DE14857; United States / NIDCR NIH HHS / DE / R01DE14857S1; United States / NIDCR NIH HHS / DE / T32DE007296-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDK2AP1 protein, human; 0 / Tumor Suppressor Proteins
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79. Wolter KG, Wang SJ, Henson BS, Wang S, Griffith KA, Kumar B, Chen J, Carey TE, Bradford CR, D'Silva NJ: (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia; 2006 Mar;8(3):163-72
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  • Both produced tumors in a murine floor-of-mouth model that mimics human HNSCC, exhibiting growth and invasion into adjacent tissues.
  • In the control group, tumors grew progressively, whereas in (-)-gossypol treatment groups, tumor growth was significantly suppressed.
  • Our results demonstrate that (-)-gossypol can inhibit tumor growth in an orthotopic model of aggressive HNSCC.

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  • (PMID = 16611409.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA97248; United States / NCI NIH HHS / CA / P50 CA097248; United States / NIDCR NIH HHS / DE / R01 DE013346; United States / NCI NIH HHS / CA / R01 CA083087; United States / NCI NIH HHS / CA / P30 CA046592; United States / NCI NIH HHS / CA / R01 CA83087; United States / NIDCD NIH HHS / DC / T32 DC05356; United States / NIDCR NIH HHS / DE / K08 DE014620; United States / NIDCR NIH HHS / DE / DE00452-01; United States / NCI NIH HHS / CA / 5 P30 CA46592; United States / NIDCD NIH HHS / DC / P30 DC005188; United States / NIDCR NIH HHS / DE / K23 DE000452; United States / NIDCR NIH HHS / DE / DE014620-01A1; United States / NIDCD NIH HHS / DC / T32 DC005356; United States / NIDCD NIH HHS / DC / P30 DC05188; United States / NIDCR NIH HHS / DE / R01 DE13346
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / BCL2L1 protein, human; 0 / Neoplasm Proteins; 0 / bcl-X Protein; KAV15B369O / Gossypol
  • [Other-IDs] NLM/ PMC1578526
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80. Binahmed A, Nason RW, Abdoh AA: The clinical significance of the positive surgical margin in oral cancer. Oral Oncol; 2007 Sep;43(8):780-4
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  • Seventy-two percent of tumors involved the tongue and floor of mouth, and 43% of patients presented with Stage III and IV disease.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Mandible / surgery. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 17174145.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Otoh EC, Johnson NW, Olasoji HO, Danfillo IS, Adeleke OA: Intra-oral carcinomas in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):379-85
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  • Carcinomas were commonly reported in the palate 19 (44.2%) and lip six (13.9%) and floor of mouth four (9.3%).
  • [MeSH-major] Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Squamous Cell / epidemiology. Mouth Neoplasms / epidemiology

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  • (PMID = 16269030.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 38
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82. Yeole BB: Trends in incidence of head and neck cancers in India. Asian Pac J Cancer Prev; 2007 Oct-Dec;8(4):607-12
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  • Information relating to cancer incidence trends forms the scientific basis for the planning and organization of prevention, diagnosis and treatment of cancer in a community.
  • For carrying out trend analysis the gum, the floor of mouth, the mucosa of cheek, the hard and soft palate and the uvula were grouped together and assigned as cancers of mouth.
  • The trend analysis was carried out for all sites together, tongue, mouth, hypopharynx and larynx in males and all sites together and mouth in females.

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  • (PMID = 18260738.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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83. Barlow ST, Drage NA, Thomas DW: Ectopic submandibular gland presenting as a swelling in the floor of mouth. J Laryngol Otol; 2005 Nov;119(11):928-30
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  • [Title] Ectopic submandibular gland presenting as a swelling in the floor of mouth.
  • Ultrasonic and sialographic investigation showed no salivary tissue in the expected left submandibular region, but a large salivary gland in the left floor of the mouth deep to the mylohyoid muscle.
  • [MeSH-major] Choristoma / ultrasonography. Mouth Diseases / ultrasonography. Submandibular Gland
  • [MeSH-minor] Adult. Female. Humans. Mouth Floor / ultrasonography

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  • (PMID = 16354351.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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84. Khariwala SS, Vivek PP, Lorenz RR, Esclamado RM, Wood B, Strome M, Alam DS: Swallowing outcomes after microvascular head and neck reconstruction: a prospective review of 191 cases. Laryngoscope; 2007 Aug;117(8):1359-63
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  • In contrast, floor of mouth, mandibular, and pharyngeal defects, regardless of size, had excellent long-term swallowing outcomes.

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  • (PMID = 17762269.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Zhang W, Hu M, Wang EB, Bu JQ: [The clinical application of acellular dermal matrix to repair the defect of oral mucosa]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 May;40(3):241-3
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  • Defect areas included vestibule, tongue, the floor of mouth, buccal mucosa, palate, gingival and lip.
  • [MeSH-major] Dermis / transplantation. Extracellular Matrix / transplantation. Mouth Mucosa / surgery

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  • (PMID = 15938891.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Pal K, Abdulla AM: Congenital imperforate submandibular duct in a newborn. Indian J Pediatr; 2007 Jul;74(7):687-8
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  • Varried conditions such as ranula, epidermal/dermal inclusion cyst, lymphatic cyst, thyroglossal cyst, sialolithiasis, branchial cleft cyst are known to produce swelling in the floor of mouth.
  • Rarely imperforate or duplication anomaly of submandiblar duct may produce cystic lesion in the floor of mouth.
  • [MeSH-minor] Cysts / congenital. Cysts / diagnosis. Diagnosis, Differential. Humans. Infant, Newborn. Male

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  • [Cites] Br J Oral Maxillofac Surg. 2001 Dec;39(6):480-2 [11735147.001]
  • [Cites] Int J Pediatr Otorhinolaryngol. 1992 Sep;24(2):161-9 [1428595.001]
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  • (PMID = 17699979.001).
  • [ISSN] 0973-7693
  • [Journal-full-title] Indian journal of pediatrics
  • [ISO-abbreviation] Indian J Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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87. Viggor SF, Frezzini C, Farthing PM, Freeman CO, Yeoman CM, Thornhill MH: Amyloidosis: an unusual case of persistent oral ulceration. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):e46-50
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  • The patient presented with extensive ulceration of the tongue and alveolar ridges, and a large swelling in the floor of mouth.
  • Incisional biopsies of the tongue and floor of mouth confirmed amyloid deposition within the tissues with evidence of necrotic ulceration.
  • Amyloid deposition in the oral cavity usually manifests as macroglossia, however it can present elsewhere in the mouth as nodular or plaquelike lesions.
  • This case highlights the variable nature of this condition, and how it can present a challenge to clinicians in terms of diagnosis and treatment.
  • [MeSH-minor] Aged. Amyloid / analysis. Fatal Outcome. Humans. Macroglossia / etiology. Male. Mouth Floor / chemistry. Mouth Floor / pathology. Multiple Myeloma / complications. Tongue / chemistry. Tongue / pathology

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  • (PMID = 19773186.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid
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88. Ramchandani PL, Sabesan T, Peters WJ, Wilson AW: Another use of the Foley catheter: retraction for operations on the floor of mouth and ventral aspect of the tongue. Br J Oral Maxillofac Surg; 2005 Feb;43(1):83-4
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  • [Title] Another use of the Foley catheter: retraction for operations on the floor of mouth and ventral aspect of the tongue.
  • A Foley catheter that is passed through the nose and sutured to the tip of the tongue can be used to facilitate retraction for operations on lesions on the ventral aspect of the tongue and the floor of the mouth.
  • [MeSH-minor] Humans. Mouth Floor / surgery. Tongue / surgery

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  • (PMID = 15620784.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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89. Ito FA, de Andrade CR, Vargas PA, Jorge J, Lopes MA: Primary tuberculosis of the oral cavity. Oral Dis; 2005 Jan;11(1):50-3
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  • In this paper, we present a case of primary oral tuberculosis, affecting the floor of mouth in a 13-year-old Brazilian male patient.
  • [MeSH-minor] Adolescent. Biopsy. Diagnosis, Differential. Humans. Male. Mouth Floor

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  • (PMID = 15641968.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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90. Mallia RJ, Subhash N, Sebastian P, Kumar R, Thomas SS, Mathews A, Madhavan J: In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential. Photodiagnosis Photodyn Ther; 2010 Sep;7(3):162-75
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  • RESULTS AND DISCUSSIONS: In masticatory anatomical locations such as (gingival and hard palate) and in lining mucosa (inner lip, soft palate, floor of mouth, transition to floor of mouth, alveolus and ventral tongue) except vermillion border of lip (VBL) of healthy subjects (designated as group I), it was observed that optimum time for maximum accumulation of PpIX is 90 min.
  • CONCLUSIONS: The determination of the optimum accumulation time of ALA in oral mucosa based on NFI helps to improve the diagnostic contrast and accuracy of oral cancer diagnosis, and to plan appropriate timing for ensuing PDT.
  • [MeSH-major] Aminolevulinic Acid / pharmacokinetics. Mouth / metabolism. Mouth Diseases / diagnosis. Mouth Mucosa / anatomy & histology. Protoporphyrins / metabolism
  • [MeSH-minor] Administration, Topical. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Diagnosis, Oral. Humans. Mouth Neoplasms / diagnosis. Mouth Neoplasms / drug therapy. Mouth Neoplasms / pathology. Photochemotherapy. Spectrometry, Fluorescence. Time Factors

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  • [Copyright] (c) 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20728840.001).
  • [ISSN] 1873-1597
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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91. Yang XJ, Zheng JW, Zhou Q, Zhang SY, Yang C: Intracystic injection of pingyangmycin (PYM) might be a more favorable option for treatment of oral and plunging ranulas. Shanghai Kou Qiang Yi Xue; 2010 Aug;19(4):447-8
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  • Ranulas are mucoceles that develop as a result of mucous extravasation from the sublingual gland and typically present in the floor of mouth.

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  • (PMID = 20871968.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin
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92. Pathak KA, Shah BC: Marginal mandibulectomy: 11 years of institutional experience. J Oral Maxillofac Surg; 2009 May;67(5):962-7
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  • PURPOSE: Literature on marginal mandibulectomy deals mainly with floor of mouth cancers.
  • The purpose of the present study was to evaluate the oncologic outcome of marginal mandibulectomy in buccal sulcus cancer as compared with floor of mouth cancer.
  • Oncologic outcomes in terms of disease control and cause-specific survival for the gingival buccal and tongue/floor of mouth cancers were compared.
  • RESULTS: A total of 137 marginal mandibulectomies were done for SCC in gingival buccal complex and 24 for floor of mouth SCC.
  • Bone was microscopically involved in 13 (8.1%) cases and mucosal margin of excision showed tumor in 12 (7.5%) cases.
  • Cause-specific survival at 5 years was significantly better for buccal cancer than floor of mouth cancer (P = .041).
  • On multivariate analysis patients with floor of mouth cancer were at a 3 times higher risk of dying of disease than those with buccal cancer.
  • CONCLUSION: In carefully selected patients, marginal mandibulectomy in buccal sulcus cancer achieves at least as good local control and survival as compared with the floor of mouth cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mandible / surgery. Mouth Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 19375004.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Civantos FJ, Zitsch RP, Schuller DE, Agrawal A, Smith RB, Nason R, Petruzelli G, Gourin CG, Wong RJ, Ferris RL, El Naggar A, Ridge JA, Paniello RC, Owzar K, McCall L, Chepeha DB, Yarbrough WG, Myers JN: Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol; 2010 Mar 10;28(8):1395-400
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  • One hundred forty patients with invasive oral cancers, stage T1 and T2, N0 including 95 cancers of the tongue, 26 of the floor of mouth, and 19 other oral cancers were studied.
  • In the forty patients with proven cervical metastases, the true-positive rate was 90.2% and was superior for tongue tumors relative to floor of mouth.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Predictive Value of Tests. Prospective Studies. Reproducibility of Results

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  • (PMID = 20142602.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U10 CA076001; United States / NCI NIH HHS / CA / U24 CA114736; United States / NCI NIH HHS / CA / U24CA114736
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2834497
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94. Faustino SE, Oliveira DT, Nonogaki S, Landman G, Carvalho AL, Kowalski LP: Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma. Int J Oral Maxillofac Surg; 2008 Apr;37(4):372-8
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  • Eighty-seven patients with primary OSCC arising in the tongue or floor of mouth, clinically T1N0M0 or T2N0M0, with (pN+) and without (pN0) occult lymph-node metastases were analyzed for VEGF-C expression by malignant cells.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / blood. Lymphatic Metastasis / diagnosis. Mouth Neoplasms / blood. Vascular Endothelial Growth Factor C / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunoenzyme Techniques. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Proteins / blood. Neoplasm Staging. Prognosis

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  • (PMID = 18295452.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vascular Endothelial Growth Factor C
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95. Nakashima T, Yasumatsu R, Kuratomi Y, Masuda M, Kuwano T, Toh S, Umezaki T, Cataltepe S, Silverman GA, Komune S: Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma. Head Neck; 2006 Jan;28(1):24-30
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  • BACKGROUND: Serine proteases have important roles in tumor invasion and metastasis, and their inhibitors, serine protease inhibitors (serpins), are attractive targets for therapeutic strategies.
  • In addition, the in vivo growth and invasion was analyzed using the floor-of-mouth model of nude mice.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Squamous Cell / pathology. Gene Expression Regulation, Neoplastic / physiology. Head and Neck Neoplasms / pathology. Serpins / metabolism
  • [MeSH-minor] Animals. Biomarkers, Tumor. Blotting, Western. Cell Line. Disease Models, Animal. Female. Humans. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Invasiveness. Transfection. Tumor Cells, Cultured

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc. Head Neck 27: XXX-XXX, 2005.
  • (PMID = 16155915.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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96. Wiegand S, Eivazi B, Zimmermann AP, Neff A, Barth PJ, Sesterhenn AM, Mandic R, Werner JA: Microcystic lymphatic malformations of the tongue: diagnosis, classification, and treatment. Arch Otolaryngol Head Neck Surg; 2009 Oct;135(10):976-83
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  • [Title] Microcystic lymphatic malformations of the tongue: diagnosis, classification, and treatment.
  • Lymphatic malformations were classified into the following 4 groups according to their extent: isolated superficial microcystic lymphatic malformations of the tongue (stage I); isolated lymphatic malformations of the tongue with muscle involvement (stage II; stage IIA, involving a part of the tongue; stage IIB, involving the entire tongue); microcystic lymphatic malformations of the tongue and the floor of mouth (stage III); and extensive microcystic lymphatic malformations involving the tongue, floor of mouth, and further cervical structures (stage IV).
  • [MeSH-major] Cysts / classification. Cysts / diagnosis. Cysts / therapy. Lymphatic System / abnormalities. Tongue / abnormalities

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  • (PMID = 19841334.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antineoplastic Agents; 39325-01-4 / Picibanil
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97. Xie JM, Lv CH, Xia J, Liu YF: [Reconstruction of tissue defects with forehead island flap in gerontal patients after oral cancer surgery]. Shanghai Kou Qiang Yi Xue; 2010 Jun;19(3):259-61
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  • The flaps were used to repair oral tissue defects, such as the cheek, tongue, retromolar region and floor of mouth.
  • No tumor recurrence and metastasis occurred during 6 months to 2 years of follow-up.
  • [MeSH-minor] Aged. Face. Humans. Mouth Neoplasms. Reconstructive Surgical Procedures. Skin Transplantation. Surgery, Oral

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  • (PMID = 20635037.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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98. Warburton G, Nikitakis NG, Roberson P, Marinos NJ, Wu T, Sauk JJ Jr, Ord RA, Wahl SM: Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma. J Oral Maxillofac Surg; 2007 Mar;65(3):475-84
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  • MATERIALS AND METHODS: Clinical, histological, and immunohistochemical analyses were undertaken for 29 patients with T1N0M0 or T2N0M0 oral SCC affecting the tongue or floor of mouth and correlated with the development of DNM.
  • RESULTS: Tumor thickness, nuclear pleomorphism, pattern of invasion, and immunohistochemical expression of the lymphangiogenesis-associated molecules VEGFR-3 and VEGF-C were associated with DNM.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lymphatic Metastasis / diagnosis. Mouth Neoplasms / pathology. Vascular Endothelial Growth Factor Receptor-3 / biosynthesis. Vascular Endothelial Growth Factors / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunoenzyme Techniques. Lymphangiogenesis / physiology. Male. Middle Aged. Neoplasm Staging. Prognosis. ROC Curve. Regression Analysis. Retrospective Studies. Sensitivity and Specificity. Vascular Endothelial Growth Factor C / analysis. Vascular Endothelial Growth Factor C / biosynthesis. Vascular Endothelial Growth Factor D / analysis. Vascular Endothelial Growth Factor D / biosynthesis

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  • (PMID = 17307596.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D; 0 / Vascular Endothelial Growth Factors; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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99. Mueller DT, Callanan VP: Congenital malformations of the oral cavity. Otolaryngol Clin North Am; 2007 Feb;40(1):141-60, vii
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  • Congenital malformations of the oral cavity may involve the lips, jaws, hard palate, floor of mouth, and anterior two thirds of the tongue.
  • [MeSH-major] Mouth Abnormalities
  • [MeSH-minor] Choristoma / diagnosis. Gingival Neoplasms / congenital. Glossitis / surgery. Humans. Jaw Abnormalities. Labial Frenum / abnormalities. Lip / abnormalities. Macrostomia / surgery. Mandible / abnormalities. Maxilla / abnormalities. Micrognathism. Mucocele / surgery. Tongue / abnormalities

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  • (PMID = 17346565.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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100. Behren A, Kamenisch Y, Muehlen S, Flechtenmacher C, Haberkorn U, Hilber H, Myers JN, Bergmann Z, Plinkert PK, Simon C: Development of an oral cancer recurrence mouse model after surgical resection. Int J Oncol; 2010 Apr;36(4):849-55
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  • In order to provide a better understanding of the development of these local recurrences after surgical ablation, we developed an orthotopic floor-of-mouth squamous cell carcinoma murine model, in which local recurrences occur at a high frequency (55%, 8 out of 15 mice) within 6-21 days after microsurgical removal of the primary.
  • Expression of the enhanced green fluorescent protein (eGFP) in the cancer cells allows in this new model to confirm complete surgical resection under the microscope and helps to track repopulating primary tumor cells in the local recurrence by optical imaging.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Disease Models, Animal. Mouth Neoplasms / surgery. Neoplasm Recurrence, Local. Oral Surgical Procedures
  • [MeSH-minor] Animals. Cell Line, Tumor. Female. Green Fluorescent Proteins / biosynthesis. Green Fluorescent Proteins / genetics. Lymphatic Metastasis. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Invasiveness. Time Factors. Transfection. Tumor Burden

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  • (PMID = 20198328.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins
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