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1. Barnes LD, Pearce JW, Berent LM, Fox DB, Giuliano EA: Surgical management of orbital nodular granulomatous episcleritis in a dog. Vet Ophthalmol; 2010 Jul;13(4):251-8
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  • Examples of primary episcleral inflammation in the dog include diffuse episcleritis, NGE, nodular fasciitis, fibrous histiocytoma, proliferative conjunctivitis/keratoconjunctivitis, pseudotumor, and Collie granuloma.

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  • (PMID = 20618804.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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2. Velazquez EF, Werchniack AE, Granter SR: Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. Am J Dermatopathol; 2010 Jun;32(4):333-9
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  • To expand this clinicopathologic spectrum, we report 6 cases of an unusual variant of desmoplastic SCC in which the "desmoplastic" areas are predominantly composed of cytologically bland malignant spindle cells mimicking a reactive/benign scarring process.
  • Two of 6 patients died of metastatic SCC; 1 patient died of unrelated causes; and 3 patients were alive without evidence of disease.
  • Accurate recognition of this entity is essential because of potential misdiagnosis as a benign process including scar and dermatofibroma.


3. Canelas MM, Cardoso JC, Andrade PF, Reis JP, Tellechea O: Fibrous histiocytomas: histopathologic review of 95 cases. An Bras Dermatol; 2010 Mar-Apr;85(2):211-5
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  • [Title] Fibrous histiocytomas: histopathologic review of 95 cases.
  • Fibrous histiocytoma (FH) is a heterogeneous tumor composed of fibroblasts, histiocytes, and blood vessels.
  • We conducted a retrospective histopathologic analysis of 95 biopsies, performed over the last 3.5 years, of fibrous histiocytomas to analyze the location, delimitation, epithelial changes, induction of folliculo-sebaceous structures, cellularity, vascularity, collagen pattern, and types of composite cells of the FH.
  • In the majority of the biopsies, we confirmed the classical histopathologic features of fibrous histiocytomas.
  • The presence of lymphoid nodules, mast cells, and sparse infiltrate of inflammatory cells was an interesting finding observed in our study.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 20520936.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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4. Martel Villagrán J, Bueno Horcajadas A, Escribano Vera J, Jiménez Jurado D: [Radiological characteristics of malignant fibrous histiocytoma of bone]. Radiologia; 2007 May-Jun;49(3):189-93
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  • [Title] [Radiological characteristics of malignant fibrous histiocytoma of bone].
  • [Transliterated title] Características radiológicas del fibrohistiocitoma maligno del hueso.
  • Malignant fibrous histiocytoma (MFH) was only recognized as a primary bone tumor a few years ago.
  • Although it is much rarer than malignant fibrous histiocytoma of soft tissues, it is not extremely uncommon.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / radiography. Magnetic Resonance Imaging


5. Kuroda K, Tajima S: Proliferation of HSP47-positive skin fibroblasts in dermatofibroma. J Cutan Pathol; 2008 Jan;35(1):21-6
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  • [Title] Proliferation of HSP47-positive skin fibroblasts in dermatofibroma.
  • BACKGROUND: The cell origin of dermatofibroma (DF) has not been clarified satisfactorily.
  • [MeSH-major] Fibroblasts / metabolism. HSP47 Heat-Shock Proteins / metabolism. Histiocytoma, Benign Fibrous / metabolism. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18095990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / HSP47 Heat-Shock Proteins; 0 / SERPINH1 protein, human; EC 2.3.2.13 / Factor XIIIa
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6. Morales Alba NA: Posterior placement of an expandable cage for lumbar vertebral body replacement in oncologic surgery by posterior simple approach: technical note. Spine (Phila Pa 1976); 2008 Nov 1;33(23):E901-5
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  • METHODS: A 17-year-old woman with a benign fibrous histiocytoma in L5 with severe bone destruction, anterior and posterior underwent posterior decompression, vertebral body replacement at the same approach with an expandable cage and L4 S1 pedicle screw fixation in a single stage surgery.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Lumbar Vertebrae / surgery. Orthopedic Procedures / instrumentation. Reconstructive Surgical Procedures / instrumentation. Spinal Neoplasms / surgery

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  • (PMID = 18978584.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Kim HJ, Shields CL, Eagle RC Jr, Shields JA: Fibrous histiocytoma of the conjunctiva. Am J Ophthalmol; 2006 Dec;142(6):1036-43
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  • [Title] Fibrous histiocytoma of the conjunctiva.
  • PURPOSE: To review the clinical features and course of six patients with fibrous histiocytoma (FH) of the conjunctiva.
  • Surgical resection was performed in all cases, and histopathologic study demonstrated benign FH in four cases and malignant FH in two cases.
  • Those cases with benign FH showed no recurrence over nine months (median, eight months; range, three to 18 months).
  • CONCLUSION: FH is a rare conjunctival tumor that can show benign or malignant features.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 17157587.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Kim HJ, Lee JY, Kim SH, Seo YJ, Lee JH, Park JK, Kim MH, Cinn YW, Cho KH, Yoon TY: Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34. Br J Dermatol; 2007 Aug;157(2):319-24
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  • [Title] Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34.
  • BACKGROUND: The distinction between dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) is a well-known challenge for dermatopathologists.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Dermatofibrosarcoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Matrix Metalloproteinase 11 / metabolism

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  • (PMID = 17596171.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.3.2.13 / Factor XIIIa; EC 3.4.24.- / Matrix Metalloproteinase 11
  • [Number-of-references] 24
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9. Agaimy A, Gaumann A, Schroeder J, Dietmaier W, Hartmann A, Hofstaedter F, Wünsch PH, Mentzel T: Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation. Virchows Arch; 2007 Nov;451(5):949-57
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  • [Title] Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation.
  • Primary and metastatic so-called malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma (MFH) is rare in the gastrointestinal (GI) tract with approximately 50 primary and five metastatic cases reported so far.
  • One patient died post-operatively, and the other was disease-free at 6 months.
  • [MeSH-major] Gastrointestinal Neoplasms / diagnosis. Histiocytoma, Malignant Fibrous / pathology. Sarcoma / pathology


10. Zaiden R, Latif N, Pham D, Hosenpud J: Dermatofibroma protuberans arising from an infected insect bite. Clin Adv Hematol Oncol; 2009 Jun;7(6):404-8
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  • [Title] Dermatofibroma protuberans arising from an infected insect bite.

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  • [CommentIn] Clin Adv Hematol Oncol. 2009 Jun;7(6):406-8 [19606077.001]
  • (PMID = 19606076.001).
  • [ISSN] 1543-0790
  • [Journal-full-title] Clinical advances in hematology & oncology : H&O
  • [ISO-abbreviation] Clin Adv Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Giovani P, Patrikidou A, Ntomouchtsis A, Meditskou S, Thuau H, Vahtsevanos K: Benign fibrous histiocytoma of the buccal mucosa: case report and literature review. Case Rep Med; 2010;2010:306148
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  • [Title] Benign fibrous histiocytoma of the buccal mucosa: case report and literature review.
  • Benign fibrous histiocytoma is an interesting and challenging entity even in its most usual, cutaneous presentation.

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  • (PMID = 20589214.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Nair SP, Moorthy KP, Suprakasan S, Jayapalan S, Mini G: Histoid leprosy - unusual presentation. Int J Dermatol; 2006 Apr;45(4):433-4
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  • The differential diagnosis for the tumor-like thigh masses included dermatofibroma, neurofibroma, and Kaposi's sarcoma.

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  • (PMID = 16650172.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leprostatic Agents
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13. Morgan MB, Purohit C, Anglin TR: Immunohistochemical distinction of cutaneous spindle cell carcinoma. Am J Dermatopathol; 2008 Jun;30(3):228-32
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  • Spindle cell carcinoma must be distinguished from spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, atypical fibroxanthoma (AFX), and scar.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cicatrix / diagnosis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Keratinocytes / chemistry. Keratinocytes / pathology. Keratins / analysis. Leiomyosarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Predictive Value of Tests

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  • (PMID = 18496422.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CK-34 beta E12; 68238-35-7 / Keratins
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14. Sakamoto A: Atypical fibroxanthoma. Clin Med Oncol; 2008;2:117-27
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  • [Title] Atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis.
  • AFX, as well as MFH (malignant fibrous histiocytoma), is a fibrohistiocytic lesion with myofibroblastic differentiation.

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  • (PMID = 21892274.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3161641
  • [Keywords] NOTNLM ; atypical fibroxanthoma / malignant fibrous histiocytoma / malignant melanoma / squamous cell carcinoma
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15. Córdoba S, Hernández A, Romero A, Arias D, Castaño E, García-Donoso C, Borbujo JM: [Basal cell carcinoma overlying a dermatofibroma]. Actas Dermosifiliogr; 2005 Nov;96(9):612-5
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  • [Title] [Basal cell carcinoma overlying a dermatofibroma].
  • [Transliterated title] Carcinoma basocelular sobre dermatofibroma.
  • The epidermis over a dermatofibroma may show changes that range from simple hyperplasia to the proliferation of basaloid cells, which can become morphologically indistinguishable from basal cell carcinoma.
  • The existence of a true basal cell carcinoma overlying a dermatofibroma is infrequent.
  • These basaloid proliferations have usually been considered to be the result of the inductive effect of the fibrohistiocytic proliferation of the dermatofibroma on the epithelial cells of the hair follicle; therefore, it would be a reactive phenomenon and not truly neoplastic.
  • We describe a case of dermatofibroma that presented with a basaloid proliferation identical in appearance to a basal cell carcinoma on the overlying epidermis.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 16476308.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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16. Fullen DR, Garrisi AJ, Sanders D, Thomas D: Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays. J Cutan Pathol; 2008 Nov;35 Suppl 2:28-34
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  • Previous studies reported S100A6 expression in atypical fibroxanthomas (AFX) but not in a small number of desmoplastic melanomas (DM).

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  • (PMID = 18201235.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / S100 Proteins; 105504-00-5 / S100A6 protein, human
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17. Pérez LP, Zulaica A, Rodríguez L, Campo MC, Peñaranda JM, Fernández-Redondo V, Toribio J: Multinucleate cell angiohistiocytoma. Report of five cases. J Cutan Pathol; 2006 May;33(5):349-52
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  • It must be distinguished from other diverse cutaneous lesions, notably dermatofibroma, Kaposi sarcoma, and angiofibroma.
  • [MeSH-major] Histiocytoma / pathology. Skin / blood supply. Skin Diseases / pathology

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  • (PMID = 16640541.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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18. Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM: Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review. Ear Nose Throat J; 2010 Nov;89(11):534-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma, Spitz nevus, and xanthogranuloma.
  • We believe that the large size of this study and the data on disease incidence will allow clinicians to be better informed of the differential diagnosis of neoplasms of the nasal cavity and paranasal sinuses in the pediatric population.


19. Anderson HL, Joseph AK: A pilot feasibility study of a rare skin tumor database. Dermatol Surg; 2007 Jun;33(6):693-6
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  • Atypical fibroxanthoma was the rare tumor most often treated.

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  • (PMID = 17550446.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Yoneda K, Demitsu T, Matsuda Y, Kubota Y: Possible molecular pathogenesis for plate-like sebaceous hyperplasia overlying dermatofibroma. Br J Dermatol; 2008 Apr;158(4):840-2
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  • [Title] Possible molecular pathogenesis for plate-like sebaceous hyperplasia overlying dermatofibroma.
  • [MeSH-major] Hedgehog Proteins / metabolism. Histiocytoma, Benign Fibrous / metabolism. Sebaceous Glands / metabolism

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  • (PMID = 18241278.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hedgehog Proteins
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21. Skoulakis CE, Papadakis CE, Datseris GE, Drivas EI, Kyrmizakis DE, Bizakis JG: Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature. Acta Otorhinolaryngol Ital; 2007 Apr;27(2):90-3
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  • [Title] Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature.
  • Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells.
  • Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues.
  • The diagnosis of fibrous histiocytoma may be clinically difficult when the lesion is located in the deep tissues, and is frequently confirmed after local excision.
  • The most important diagnostic distinction is the separation of this tumour from aggressive forms of fibrohistiocytic neoplasms, including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma.
  • The lesion had been totally excised under local anaesthesia, and histopathology revealed a benign fibrous histiocytoma.
  • The diagnosis, location, treatment and prognosis of fibrous histiocytoma are also discussed.
  • [MeSH-major] Cheek / pathology. Histiocytoma, Benign Fibrous / pathology

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  • [Cites] J Cutan Pathol. 2000 Jan;27(1):36-9 [10660130.001]
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  • (PMID = 17608138.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC2640009
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22. Ichikawa N, Kobayashi M, Kimoto M, Tanikawa A, Tanaka M: A case of multiple aneurysmal fibrous histiocytomas. Br J Dermatol; 2005 Sep;153(3):664-5
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  • [Title] A case of multiple aneurysmal fibrous histiocytomas.
  • [MeSH-major] Aneurysm / pathology. Histiocytoma, Benign Fibrous / pathology. Sjogren's Syndrome / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 16120163.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] England
  • [Number-of-references] 5
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23. Chaâbouni S, Ayadi L, Masmoudi A, Dhouib M, Méziou J, Dammak A, Charfi S, Gouiaa N, Turki H, Abdelmoula M, Boudawara T: [Retroauricular dermatofibroma in a child simulating a malignant tumour]. Arch Pediatr; 2008 Mar;15(3):283-5
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  • [Title] [Retroauricular dermatofibroma in a child simulating a malignant tumour].
  • BACKGROUND: Dermatofibroma represents one of the commonest benign soft tissue tumours, and its diagnosis is usually straightforward if classical clinicopathologic features are evident.
  • We report a peculiar case of an aggressive cellular dermatofibroma in a child that simulated a malignant tumour.
  • The lesion had the full microscopic characteristics of a cellular dermatofibroma.
  • CONCLUSION: Dermatofibroma is one of the major differential diagnosis of nodular cutaneous tumours in children that simulate malignancy.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18325746.001).
  • [ISSN] 0929-693X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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24. Belliveau MJ, Brownstein S, Jordan DR, Faraji H: Low-grade, aggressive fibrous histiocytoma of the medial canthus. Can J Ophthalmol; 2008 Apr;43(2):250
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  • [Title] Low-grade, aggressive fibrous histiocytoma of the medial canthus.

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  • (PMID = 18347642.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Ruano Poblador A, Carracedo Iglesias R, García Martínez MT, Oliver Morales J, Casal Nuñez JE: [Metastasis to descending colon of an epididymal malignant fibrous histiocytoma]. Cir Esp; 2009 May;85(5):321-3
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  • [Title] [Metastasis to descending colon of an epididymal malignant fibrous histiocytoma].
  • [Transliterated title] Metástasis en colon izquierdo de histiocitoma fibroso maligno del epidídimo derecho.
  • [MeSH-major] Colonic Neoplasms / secondary. Epididymis. Genital Neoplasms, Male / pathology. Histiocytoma, Malignant Fibrous / secondary

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  • [CommentIn] Cir Esp. 2010 Mar;87(3):195-6; author reply 196 [20092815.001]
  • (PMID = 19376501.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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26. Clarke LE, Frauenhoffer E, Fox E, Neves R, Bruggeman RD, Helm KF: CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. J Cutan Pathol; 2010 Jul;37(7):737-43
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  • [Title] CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma.
  • CD10 is now commonly used to differentiate atypical fibroxanthoma (AFX) from melanoma, spindle cell and dedifferentiated variants of squamous cell carcinoma and leiomyosarcoma.
  • [MeSH-major] Fibrosarcoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Neprilysin / biosynthesis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20175824.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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27. McGregor DH, Cherian R, Romanas MM, Ulusarac O, Mathur SC, Feldman MM: Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma. Ann Clin Lab Sci; 2008;38(2):157-62
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  • [Title] Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma.
  • This lesion was composed of 2 distinct contiguous neoplastic infiltrates, the predominant component being an atypical fibroxanthoma and the smaller component an amelanotic melanoma (primary vs metastatic), with diagnostic confirmation requiring multiple immunohistochemical stains.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma, Amelanotic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18469362.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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28. Gencoglan G, Karaarslan IK, Akalin T, Ozdemir F: Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy. Australas J Dermatol; 2009 Nov;50(4):301-2
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  • The lesion was excised with the pre-operative diagnosis of melanoma, blue naevus and dermatofibroma.
  • Although homogeneous blue pigmentation on dermoscopy is the hallmark of blue naevus, it may be seen in metastatic melanoma and exceptionally in hemosiderotic and cellular types of dermatofibroma.

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  • (PMID = 19916979.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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29. Luzar B, Calonje E: Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review. J Cutan Pathol; 2010 Mar;37(3):301-9
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  • [Title] Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review.
  • The present manuscript gives emphasis on recognizing different morphological variants of atypical fibroxanthoma (AFX), on validation of immunohistochemical markers and on discussing potential diagnostic pitfalls.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology


30. Khalkhali K, Azizi MR, Atighechi S: A fibrous histiocytoma of intermediate malignancy arisen from the parotid gland. Arch Iran Med; 2007 Jan;10(1):100-3
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  • [Title] A fibrous histiocytoma of intermediate malignancy arisen from the parotid gland.
  • The light microscopic and immunohistochemical characteristics of a case of fibrous histiocytoma of intermediate malignancy arising from the parotid gland are presented.
  • Histologic characteristics similar to those displayed by dermatofibroma and dermatofibrosarcoma protuberans help to differentiate this tumor from other spindle cell tumors.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17198464.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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31. Stefanato CM, Robson A, Calonje JE: The histopathologic spectrum of regression in atypical fibroxanthoma. J Cutan Pathol; 2010 Mar;37(3):310-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The histopathologic spectrum of regression in atypical fibroxanthoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) with prominent fibrosis, sclerosis and hyalinization, and near-total tumor regression is rare.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology


32. Mathew RA, Schlauder SM, Calder KB, Morgan MB: CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol; 2008 Feb;30(1):34-6
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  • [Title] CD117 immunoreactivity in atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly.
  • Though described as a benign entity, local recurrence and distant metastasis have been reported.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism

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  • [CommentIn] Am J Dermatopathol. 2008 Aug;30(4):401-2 [18645317.001]
  • [CommentIn] Am J Dermatopathol. 2009 Feb;31(1):96-8 [19155737.001]
  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):640-2 [19033951.001]
  • (PMID = 18212542.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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33. Fernandez-Flores A: Cutaneous squamous cell carcinoma of different grades: variation of the expression of CD10. Cesk Patol; 2008 Oct;44(4):100-2
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  • 3) our results seem contradictory to the current view that has defended atypical fibroxanthoma as an anaplastic type of SCC, since the former expresses CD10 in virtually 100 % of the cases.


34. Beer TW: CD117 in atypical fibroxanthoma: tumor or stroma? Am J Dermatopathol; 2008 Aug;30(4):401-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD117 in atypical fibroxanthoma: tumor or stroma?
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism. Stromal Cells / metabolism

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  • [CommentOn] Am J Dermatopathol. 2008 Feb;30(1):34-6 [18212542.001]
  • (PMID = 18645317.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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35. Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA: Nonmelanocytic lesions defying the two-step dermoscopy algorithm. Dermatol Surg; 2006 Nov;32(11):1398-406
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  • Seborrheic keratosis, solar lentigo, dermatofibroma, and supernumerary accessory nipple may present with network-like structures.
  • Seborrheic keratosis, dermatofibroma, subcorneal hemorrhage, basal cell carcinoma (BCC), and cutaneous metastases of breast and other cancers may contain pigmented globules.
  • Homogenous bluish pigmentation, simulating a blue nevus, can also be seen in benign vascular lesions, Kaposi sarcoma, radiation tattoo, and BCC.

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  • (PMID = 17083595.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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36. Ruiz Liso JM, Ruiz García J, Pardo López ML, Vaillo Vinagre A, Gutiérrez Martín A, Marrón Martínez MC, García Pérez MA: [Inflammatory malignant fibrous histiocytoma of the spermatic cord infiltrating an inguinal leiomyoma. Case report with conceptual and bibliographic reviews]. Arch Esp Urol; 2008 May;61(4):485-98
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  • [Title] [Inflammatory malignant fibrous histiocytoma of the spermatic cord infiltrating an inguinal leiomyoma. Case report with conceptual and bibliographic reviews].
  • [Transliterated title] Fibrohistiocitoma maligno "inflamatorio" de cordón espermático con infiltración sobre un leiomioma inguinal. Presentación de 1 caso con revisión conceptual y de la literatura.
  • OBJECTIVES: To study paratesticular malignant fibrous histiocytomas (FHM) from the clinical, histological, immunohistochemical and histogenetic, point of view.
  • Today, this term is synonymous of pleomorphic undifferentiated sarcoma and has been an exclusion diagnosis (Vimentin [+]/ CD 68 [+]--occasionally--without ultrastructural differences), reserving the inflammatory subtype for which they have an inflammatory and histiocytic component.
  • The accomplishment of an intraoperatory biopsy is essential in this location, since it is even difficult to know preoperatively, if a lesion is benign or malignant.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Histiocytoma / pathology. Inguinal Canal. Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology. Spermatic Cord

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  • (PMID = 18592766.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 84
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37. Kandal S, Ozmen S, Demir HY, Tuncer S, Ekinci O, Atabay K: Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. Plast Reconstr Surg; 2005 Dec;116(7):2050-1
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  • [Title] Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16327640.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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38. Bisceglia M, Attino V, Bacchi CE: Metastasizing "benign" fibrous histiocytoma of the skin: a report of two additional cases and review of the literature. Adv Anat Pathol; 2006 Mar;13(2):89-96
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  • [Title] Metastasizing "benign" fibrous histiocytoma of the skin: a report of two additional cases and review of the literature.
  • [MeSH-major] Histiocytoma, Benign Fibrous / complications. Neoplasm Recurrence, Local. Skin Neoplasms / diagnosis

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  • (PMID = 16670464.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Balaji SM: Malignant fibrous histiocytoma-case report. J Maxillofac Oral Surg; 2010 Sep;9(3):292-6
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  • [Title] Malignant fibrous histiocytoma-case report.
  • Fibrous histiocytoma is a tumor composed of a mixture of fibroblastic and histiocytic cells.
  • We present a unique case of malignant fibrous histiocytoma developing in left buccal mucosa very near to the surgical margin from which a benign fibrous histiocytoma of the mandible was excised 3 years earlier in a 31 year old female.

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  • (PMID = 22190809.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177448
  • [Keywords] NOTNLM ; Benign fibrous histiocytoma / Malignant change / Malignant fibrous histiocytoma
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40. Sakamoto A, Akieda S, Oda Y, Iwamoto Y, Tsuneyoshi M: Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma. BMC Dermatol; 2009;9:1
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  • [Title] Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) histologically mimics high-grade sarcoma in the skin, although it follows a benign clinical course.
  • METHODS: Immunohistochemical expression of Bax was analyzed in 7 cases of AFX, and in 7 cases of benign fibrous histiocytoma (BFH) used as a comparison.
  • [MeSH-major] Cell Cycle Proteins / genetics. Histiocytoma, Benign Fibrous / genetics. Nuclear Proteins / genetics. Skin Neoplasms / genetics

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  • (PMID = 19128509.001).
  • [ISSN] 1471-5945
  • [Journal-full-title] BMC dermatology
  • [ISO-abbreviation] BMC Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / GADD45A protein, human; 0 / Nuclear Proteins; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2628644
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41. Bermejo Casero E, Pérez Alonso D, Quevedo Losada S, López Rivero L: [Dermatofibroma metastasizing to the lung: current treatment]. Arch Bronconeumol; 2009 Oct;45(10):521-3
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  • [Title] [Dermatofibroma metastasizing to the lung: current treatment].
  • [Transliterated title] Dermatofibroma y metástasis pulmonares. Tratamiento actual.
  • They have been described histopathologically as a reaction of the connective tissue of the skin or as a benign neoplasm.
  • We present the case of a young woman with a recurrent dermatofibroma on the shoulder that metastasized to both lungs.
  • [MeSH-major] Histiocytoma, Benign Fibrous / secondary. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 19394746.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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42. Gil T, Sabo E, Kerner H, Metanes I, Har-Shai Y: Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male. J Plast Reconstr Aesthet Surg; 2010 Oct;63(10):e725-8
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  • [Title] Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male.
  • Atypical fibroxanthoma (AFX) is an uncommon spindle cell neoplasm of the elderly.
  • [MeSH-major] Alopecia / surgery. Hair / transplantation. Histiocytoma, Benign Fibrous / surgery. Lasers, Gas / adverse effects. Scalp Dermatoses / surgery. Skin Neoplasms / surgery

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  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20673656.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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43. Nakamura Y, Abe Y, Ichimiya M, Muto M: Atypical fibroxanthoma presenting immunoreactivity against CD10 and CD99. J Dermatol; 2010 Apr;37(4):387-9
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  • [Title] Atypical fibroxanthoma presenting immunoreactivity against CD10 and CD99.
  • [MeSH-major] Antigens, CD / analysis. Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Cheek. Histiocytoma, Benign Fibrous / diagnosis. Neprilysin / analysis. Skin Neoplasms / diagnosis

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  • (PMID = 20507414.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin; EC 3.4.24.11 / Neprilysin
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44. Patton A, Page R, Googe PB, King R: Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol; 2009 Nov;36(11):1177-84
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  • [Title] Myxoid atypical fibroxanthoma: a previously undescribed variant.
  • BACKGROUND: Atypical fibroxanthomas (AFX) are dermal-based cutaneous tumors typically found in sun-damaged skin of the elderly.
  • Myxoid change may be a prominent finding in benign and malignant cutaneous tumors and awareness of this variant of AFX will avoid misdiagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19320792.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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45. Thosani MK, Marghoob A, Chen CS: Current progress of immunostains in Mohs micrographic surgery: a review. Dermatol Surg; 2008 Dec;34(12):1621-36
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  • In recent years, the application of immunostaining techniques has facilitated the successful removal of a number of common and less common cutaneous malignancies, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, dermatofibrosarcoma protuberans, microcystic adnexal carcinoma, sebaceous carcinoma, atypical fibroxanthoma, extramammary Paget's disease, and even sarcomas.

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  • (PMID = 19018832.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 127
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46. Leibovitch I, Huilgol SC, Richards S, Paver R, Selva D: Scalp tumors treated with Mohs micrographic surgery: clinical features and surgical outcome. Dermatol Surg; 2006 Nov;32(11):1369-74
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  • The most common tumors were basal cell carcinoma (BCC), 57.9%; squamous cell carcinoma (SCC), 35.8%; Bowen's disease (BD), 4.1%; and atypical fibroxanthoma (AFX), 1.6%.


47. Cox NH: Halo asteatotic eczema localized around a dermatofibroma in acute-onset leg oedema. Br J Dermatol; 2008 Aug;159(2):496
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  • [Title] Halo asteatotic eczema localized around a dermatofibroma in acute-onset leg oedema.
  • [MeSH-major] Eczema / pathology. Edema / pathology. Histiocytoma, Benign Fibrous / pathology. Leg Dermatoses / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Acute Disease. Humans. Male. Middle Aged


48. Espiñeira-Carmona MJ, Arias-Santiago S, Aneiros-Fernández J, Fernández-Pugnaire MA, Naranjo-Sintes R: Exophytic and ulcerated lesion on the leg. Dermatol Online J; 2010;16(10):12
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  • After surgical excision the histological study confirmed the diagnosis of a polypoid dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Skin Ulcer / pathology

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  • (PMID = 21062606.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Dim-Jamora KC, Perone JB: Management of cutaneous tumors with mohs micrographic surgery. Semin Plast Surg; 2008 Nov;22(4):247-56
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  • We discuss the use of Mohs micrographic surgery for the following cutaneous tumors: basal cell carcinoma, squamous cell carcinoma, melanoma in situ, dermatofibrosarcoma protuberans, Merkel cell carcinoma, microcystic adnexal carcinoma, atypical fibroxanthoma, and sebaceous carcinoma.

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  • (PMID = 20567701.001).
  • [ISSN] 1536-0067
  • [Journal-full-title] Seminars in plastic surgery
  • [ISO-abbreviation] Semin Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2884874
  • [Keywords] NOTNLM ; Mohs micrographic surgery / cutaneous oncology / skin cancer
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50. Coindre JM: Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med; 2006 Oct;130(10):1448-53
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  • Both are 3-grade systems and are mainly based on histologic type and subtype, tumor necrosis, and mitotic activity.
  • Histologic typing should be clearly defined before any attempt at grading, and grading should not be used on tumors of intermediate malignancy such as atypical fibroxanthoma and on some sarcomas such as dedifferentiated liposarcoma.

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  • (PMID = 17090186.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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51. Edelweiss M, Malpica A: Dermatofibrosarcoma protuberans of the vulva: a clinicopathologic and immunohistochemical study of 13 cases. Am J Surg Pathol; 2010 Mar;34(3):393-400
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  • Of interest, in 7 of our 13 cases, a variety of diagnoses, such as cellular dermatofibroma, cellular leiomyoma, neurofibroma, low-grade leiomyosarcoma, fibrosarcoma, low-grade malignant schwannoma, desmoplastic melanoma, cellular neurofibroma, and low-grade malignant peripheral nerve sheet tumor were initially considered.
  • Nine patients had no evidence of disease, 2 patients were alive with disease, 1 patient had died of disease, and 1 patient had died of other causes.


52. Arpaia N, Cassano N, Vena GA: Dermoscopic patterns of dermatofibroma. Dermatol Surg; 2005 Oct;31(10):1336-9
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  • [Title] Dermoscopic patterns of dermatofibroma.
  • BACKGROUND: Clinical and dermoscopic aspects of dermatofibroma (DF) are usually typical.
  • [MeSH-major] Dermoscopy. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16188191.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Warraich I, Dunn DM, Oliver JW: Solitary fibrous tumor of the orbit with epithelioid features. Arch Pathol Lab Med; 2006 Jul;130(7):1039-41
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  • [Title] Solitary fibrous tumor of the orbit with epithelioid features.
  • Extrapleural solitary fibrous tumors have often been confused with other mesenchymal tumors, such as hemangiopericytoma, fibrous histiocytoma, fibrous meningioma, and leiomyoma, because of morphologic similarity and underrecognition, especially if some unusual features are present.
  • Recently, epithelioid solitary fibrous tumor has been reported in the mediastinum.
  • We report a case of solitary fibrous tumor of the orbit with biphasic architecture, including spindle cell and epithelioid components.
  • Both components demonstrated immunohistochemical features of a solitary fibrous tumor.
  • In this report, we discuss the differential diagnosis of solitary fibrous tumor with unusual epithelioid features.
  • Extrapleural solitary fibrous tumor should be included in the differential diagnosis of tumors of the orbit with a spindle cell appearance even in the presence of some epithelioid morphology.
  • [MeSH-minor] Aged. Angiofibroma / diagnosis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Hemangiopericytoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Meningioma / diagnosis. Neurilemmoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16831031.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Beer TW: Squamous cell carcinoma with osteoclast-like giant cells: 2 cases misdiagnosed as atypical fibroxanthoma. Am J Dermatopathol; 2010 Jun;32(4):414-5
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  • [Title] Squamous cell carcinoma with osteoclast-like giant cells: 2 cases misdiagnosed as atypical fibroxanthoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Diagnostic Errors. Giant Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Osteoclasts / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Am J Dermatopathol. 2009 May;31(3):282-7 [19384071.001]
  • [CommentOn] Am J Dermatopathol. 2009 Feb;31(1):96 [19155738.001]
  • (PMID = 20145535.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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55. Wang WL, Patel KU, Coleman NM, Smith-Zagone MJ, Ivan D, Reed JA, López-Terrada D, Lazar AJ, Prieto VG: COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin. Am J Dermatopathol; 2010 Apr;32(2):149-53
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  • Indeterminate fibrohistiocytic lesions of the skin share histological and immunohistochemical features of both benign fibrous histiocytoma/dermatofibroma and dermatofibrosarcoma protuberans (DFSP).
  • Unlike dermatofibroma, DFSP harbors recurrent genetic aberrations resulting in the fusion of COL1A1 on chromosome 17 and PDGFB on chromosome 22.
  • [MeSH-major] Chimera / genetics. Collagen Type I / genetics. Dermatofibrosarcoma / genetics. Histiocytoma, Benign Fibrous / genetics. Proto-Oncogene Proteins c-sis / genetics. Skin Neoplasms / genetics


56. Kim UR, Arora V, Shanti R, Shah AD: Neglected giant atypical fibroxanthoma of the eyelid. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):408-9
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  • [Title] Neglected giant atypical fibroxanthoma of the eyelid.
  • Atypical fibroxanthoma is an uncommon neoplasm of the superficial soft tissue that occurs in actinically damaged skin of elderly patients.
  • The authors present an unusual case of neglected giant atypical fibroxanthoma of the eyelid in an elderly patient.
  • [MeSH-major] Eyelid Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19966663.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Iwasaki H, Nabeshima K, Nishio J, Jimi S, Aoki M, Koga K, Hamasaki M, Hayashi H, Mogi A: Pathology of soft-tissue tumors: daily diagnosis, molecular cytogenetics and experimental approach. Pathol Int; 2009 Aug;59(8):501-21
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  • In pleomorphic sarcoma/malignant fibrous histiocytoma, the alternative lengthening of telomeres (ALT) mechanism may result in formation of anaphase bridges and marked nuclear pleomorphism.

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  • [ErratumIn] Pathol Int. 2009 Dec;59(12):900
  • (PMID = 19627534.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Australia
  • [Number-of-references] 192
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58. Puri PK, Tyler WB, Ferringer TC: Neurofibroma with clear cell change. Am J Dermatopathol; 2009 Jul;31(5):453-6
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  • Cutaneous clear cell proliferations and degenerative change have been seen in a variety of entities including nevi, dermatofibromas, fibrous papules, atypical fibroxanthomas, basal cell carcinomas, and squamous cell carcinomas, to name a few.

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  • (PMID = 19542919.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Zaballos P, Guionnet N, Puig S, Malvehy J: Central white network: an additional dermoscopic feature for the diagnosis of dermatofibroma. Dermatol Surg; 2005 Aug;31(8 Pt 1):960-2
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  • [Title] Central white network: an additional dermoscopic feature for the diagnosis of dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16042944.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Song Y, Sakamoto F, Ito M: Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations. J Dermatol Sci; 2005 Aug;39(2):89-96
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  • [Title] Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations.
  • OBJECTIVES: In this study, we examined the fine structures and potential heterogeneity among the subgroup of factor XIIIa (FXIIIa) positive dendritic cells consisted of eleven cases of dermatofibroma (DF).
  • [MeSH-major] Dendritic Cells / metabolism. Factor XIIIa / biosynthesis. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16055004.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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61. Scalvenzi M, Balato A, De Natale F, Francia MG, Mignogna C, De Rosa G: Hemosiderotic dermatofibroma: report of one case. Dermatology; 2007;214(1):82-4
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  • [Title] Hemosiderotic dermatofibroma: report of one case.
  • Dermatofibroma (DF) is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathological features.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermoscopy. Diagnosis, Differential. Disease Progression. Humans. Male

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  • (PMID = 17191053.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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62. Moiseenko VM, Chudenko VA, Orlova RV, Imianitov EN, Matsko DE, Gafton GI, Kochnev VA, Protsenko SA, Mikhaĭlichenko TD, Nogaeva TKh: [Effectiveness of imatinib mesylate in treatment for dermatofibroma protuberans]. Vopr Onkol; 2008;54(5):656-60
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  • [Title] [Effectiveness of imatinib mesylate in treatment for dermatofibroma protuberans].

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  • (PMID = 19069485.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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63. Kluger N, Cotten H, Magana C, Pinquier L: Dermatofibroma occurring within a tattoo: report of two cases. J Cutan Pathol; 2008 Jul;35(7):696-8
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  • [Title] Dermatofibroma occurring within a tattoo: report of two cases.
  • [MeSH-major] Coloring Agents / adverse effects. Histiocytoma, Benign Fibrous / etiology. Skin Neoplasms / etiology. Tattooing / adverse effects

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  • (PMID = 18582244.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents
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64. Battistella M, Trabelsi S, Terrier-Lacombe MJ, Leboulleux S, Robert C: Hypermetabolic dermatofibroma on Positron Emission Tomography/Computed tomography with 18F-FluoroDeoxyGlucose : a misleading false positive in the follow-up of a metastatic melanoma. Eur J Dermatol; 2008 Jul-Aug;18(4):461-2
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  • [Title] Hypermetabolic dermatofibroma on Positron Emission Tomography/Computed tomography with 18F-FluoroDeoxyGlucose : a misleading false positive in the follow-up of a metastatic melanoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Melanoma / diagnosis. Positron-Emission Tomography. Skin Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 18573725.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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65. Hussein MR: Skin metastasis: a pathologist's perspective. J Cutan Pathol; 2010 Sep;37(9):e1-20
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  • Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs.
  • Some skin metastasis may mimic specific dermatological conditions such as cutaneous cyst, dermatofibroma, pyogenic granuloma, hemangioma, papular eruptions, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, cellulitis and erysipelas.

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  • (PMID = 19922483.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
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66. Zaballos P, Puig S, Malvehy J: Dermoscopy of atypical dermatofibroma: central white network. Arch Dermatol; 2006 Jan;142(1):126
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  • [Title] Dermoscopy of atypical dermatofibroma: central white network.
  • [MeSH-major] Dermoscopy. Histiocytoma, Benign Fibrous / pathology. Skin / pathology

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  • (PMID = 16415404.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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67. Maier PC, Auw-Hädrich C, Reinhard T: [Recurrent fibrous histiocytoma at the corneoscleral limbus]. Klin Monbl Augenheilkd; 2008 Jan;225(1):99-100
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  • [Title] [Recurrent fibrous histiocytoma at the corneoscleral limbus].
  • [Transliterated title] Rezidivierendes fibröses Histiozytom am korneoskleralen Limbus.
  • This case report describes a rare fibrous histiocytoma at the corneoscleral limbus in a 10-year-old boy.
  • In our patient the tumour was histologically classified as benign, however, it presented with an invasive growth pattern and recurrency, so that a penetrating sclerokeratoplasty became necessary.
  • [MeSH-major] Corneal Diseases / surgery. Eye Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Keratoplasty, Penetrating. Limbus Corneae / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18236380.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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68. Bugatti L, Filosa G: Dermatoscopic features of cutaneous atypical fibroxanthoma: three cases. Clin Exp Dermatol; 2009 Dec;34(8):e898-900
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  • [Title] Dermatoscopic features of cutaneous atypical fibroxanthoma: three cases.
  • Atypical fibroxanthoma (AFX) is an uncommon, low-grade, malignant, spindle-cell tumour of fibrohistiocytic histogenesis, which can mimic other malignant skin tumours, such as basal and squamous cell carcinoma (CC), melanoma, and Merkel cell carcinoma (MCC).
  • [MeSH-major] Dermoscopy / methods. Histiocytoma, Benign Fibrous / pathology. Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 20055861.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Kanner WA, Brill LB 2nd, Patterson JW, Wick MR: CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol; 2010 Jul;37(7):744-50
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  • [Title] CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is a pleomorphic spindle cell lesion of the skin; it is considered in the differential diagnosis with spindle cell malignant melanoma (MM) and sarcomatoid carcinoma/spindle cell squamous cell carcinoma (SCC).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis


70. Chen JT, Hsu JD, Yao CC, Han LW, Han CP: Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543. J Cutan Pathol; 2010 Oct;37(10):1123-4
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  • [Title] Anti-cytokeratin CAM 5.2 does not act as a surrogate of the cytokeratin 8/18 monoclonal antibody. Comment on: "Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma", in J Cutan Pathol 2009; 36: 543.

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  • [CommentOn] J Cutan Pathol. 2009 May;36(5):543-7 [19476522.001]
  • (PMID = 20175827.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 0 / Keratin-18; 0 / Keratin-8; 68238-35-7 / Keratins
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71. Kemmerling R, Dietze O, Müller S, Neureiter D: Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma. Pathol Res Pract; 2009;205(5):365-70
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  • [Title] Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma.
  • We present a clear-cell atypical fibroxanthoma (CCAFX) and describe the morphological and immunohistochemical aspects of this rare skin lesion.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19155147.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Orrock JM, Abbott JJ, Gibson LE, Folpe AL: INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics. Am J Dermatopathol; 2009 Apr;31(2):152-6
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  • The morphological features of epithelioid sarcoma may closely mimic those of epithelial neoplasms, such as squamous cell carcinoma, mesenchymal tumors, such as benign fibrous histiocytoma, and nonneoplastic lesions, such as granuloma annulare.
  • Twenty-four cases of epithelioid sarcoma, 13 cases of granuloma annulare, 10 cases of rheumatoid nodule, 19 cases of cutaneous squamous cell carcinoma, 7 cases of atypical fibroxanthoma, 9 cases of benign fibrous histiocytoma (dermatofibroma), and 3 cases of nodular fasciitis were immunostained for GLUT-1 and INI1 using commercially available antibodies, heat-induced epitope retrieval, and the Dako Envision detection system.
  • GLUT-1 was positive in 40%-50% of epithelioid sarcomas, all cases of granuloma annulare and rheumatoid nodules, 67% of benign fibrous histiocytomas, and in all squamous cell carcinomas.
  • In contrast, atypical fibroxanthomas and cases of nodular fasciitis were consistently GLUT-1 negative.
  • In this clinical context, loss of INI1 expression seems to be an entirely specific marker of epithelioid sarcoma and this finding may be of great value in distinguishing CD34-negative epithelioid sarcoma from squamous cell carcinoma and in the distinction of rare cytokeratin-negative epithelioid sarcomas from necrobiotic processes, nodular fasciitis, and benign fibrous histiocytomas.
  • [MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / pathology. Rheumatoid Nodule / metabolism. Rheumatoid Nodule / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology

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  • (PMID = 19318800.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glucose Transporter Type 1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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73. Arsenovic N, Sen S, Naik V, Reed M, Moreira R: Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma. Am J Dermatopathol; 2009 Aug;31(6):587-90
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  • [Title] Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma.
  • Therefore, the lesion was designated as atypical fibroxanthoma (AFX) by exclusion.
  • [MeSH-major] Carcinoma in Situ / pathology. Epidermal Cyst / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 19590414.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Bahrami A, Folpe AL: Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol; 2010 Oct;34(10):1504-13
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  • Revised diagnoses were based on clinical, morphologic, IHC, and molecular findings.
  • Twelve patients (50%) died of locally aggressive and/or metastatic disease (median follow-up 1-year; range <1 to 8 y), 6 patients (25%) were alive without disease (median follow-up 11.5 y; range 2.5 to 35 y), and 6 patients (25%) died of other causes (median follow-up 10 y; range 9 to 18 y) ().
  • Non-FS (137 cases) were reclassified as: undifferentiated pleomorphic sarcoma (32 cases), SS (21 cases), solitary fibrous tumor (14 cases), myxofibrosarcoma (11 cases), malignant peripheral nerve sheath tumor (8 cases), FS dermatofibrosarcoma protuberans, and desmoplastic melanoma (4 cases each), low-grade fibromyxoid sarcoma, sarcomatoid carcinoma, desmoid-type fibromatosis, rhabdomyosarcoma, myofibroblastic sarcoma, spindle-cell liposarcoma (3 cases each), sclerosing epithelioid FS, fibroma-like epithelioid sarcoma, leiomyosarcoma, cellular fibrous histiocytoma (2 cases each), and others (17 cases).
  • Exclusive of undifferentiated pleomorphic sarcoma, the distinction of which from FS is subjective, 64% of putative FS were reclassified, most commonly as monophasic SS and solitary fibrous tumor.


75. Muchemwa FC, Wakasugi S, Honda Y, Ihn H: PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. Clin Exp Dermatol; 2010 Apr;35(3):295-9
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  • Quantitative RT-PCR identified all samples as having significantly higher expression of the PDGFB gene compared with normal skin or dermatofibroma.

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  • (PMID = 19663837.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / COLIA1-PDGFB fusion protein, human; 0 / Collagen Type I; 0 / Oncogene Proteins, Fusion; 0 / Platelet-Derived Growth Factor
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76. Mourmouras V, Falzarano SM, Malagnino V, Miracco C: Compound melanocytic nevus associated with dermatofibroma: an additional case. J Cutan Pathol; 2007 Sep;34(9):736-7
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  • [Title] Compound melanocytic nevus associated with dermatofibroma: an additional case.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17696924.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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77. Gencoglan G, Karaarslan IK, Dereli T, Kazandi AC: Dermatofibroma on the palmar surface of the hand. Skinmed; 2008 Jan-Feb;7(1):41-3
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  • [Title] Dermatofibroma on the palmar surface of the hand.
  • Clinically, the nodular lesion appeared to be a benign tumor (Figure C).

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  • (PMID = 18174803.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Jain M, Singh S, Agarwal K: Spindle cell neoplasm of skin: diagnostic dilemma. Indian J Pathol Microbiol; 2007 Oct;50(4):814-6
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  • The vast majority of these neoplasms ultimately are diagnosed as either atypical fibroxanthoma (AFX), spindle cell melanoma (SCM), and very rarely as spindle cell squamous cell carcinoma (SCSCC), leiomyosarcoma or angiosarcoma.

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  • (PMID = 18306566.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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79. Khong JJ, Chen CS, James CL, Huilgol SC, O'Donnell BA, Sullivan TJ, Selva D: Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):103-8
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  • [Title] Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management.
  • PURPOSE: Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma that occurs rarely in the periocular region.
  • All tumors were <5 cm in diameter and of storiform pleomorphic histologic subtype.
  • The initial diagnoses were sarcomatoid carcinoma, atypical fibroxanthoma, and leiomyosarcoma that were subsequently reclassified as MFH.
  • CONCLUSIONS: This study highlights the difficulties in the clinicopathologic diagnosis of periocular MFH and in particular the distinction of more superficial tumors from atypical fibroxanthoma.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / surgery

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  • (PMID = 15778662.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K: Desmoplastic spitz nevus: report of a case and review of the literature. Pathologica; 2008 Jun;100(3):181-4
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  • The histologic features of this benign tumour may mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) or malignant (metastatic carcinoma and malignant melanoma) neoplasms.
  • The histologic presentation of this benign lesion mimics both benign and malignant neoplasms.

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  • (PMID = 18841824.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 15
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81. Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG: Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One; 2009 Nov 30;4(11):e8075
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  • [Title] Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.
  • Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma.


82. de Giorgi V, Trez E, Salvini C, Duquia R, De Villa D, Sestini S, Gervini R, Lotti T: Dermoscopy in black people. Br J Dermatol; 2006 Oct;155(4):695-9
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  • RESULTS: Of 100 clinically suspicious cases, 79 were Clark naevi, 15 seborrhoeic keratoses, four blue naevi, one dermatofibroma and one melanoma.

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  • (PMID = 16965417.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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83. Gimeno Argente V, Bosquet Sanz M, Gómez Pérez L, Delgado Oliva FJ, Arlandis Guzmán S, Jiménez Cruz JF: [Retroperitoneal malignant fibrous histiocytoma with contiguous organs infiltration]. Actas Urol Esp; 2007 May;31(5):562-6
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  • [Title] [Retroperitoneal malignant fibrous histiocytoma with contiguous organs infiltration].
  • [Transliterated title] Histiocitoma fibroso maligno retroperitoneal con infiltración de organos vecinos.
  • The mass was treated surgerically and pathological diagnosis was malignant fibrous histiocytoma.
  • [MeSH-major] Histiocytoma / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 17711179.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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84. De Padua M, Subramanium N: Benign fibrous histiocytoma of the bladder. Indian J Urol; 2007 Jan;23(1):72-4
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  • [Title] Benign fibrous histiocytoma of the bladder.
  • We present a rare case of a bladder benign fibrous histiocytoma in a 52-year-old male.
  • Histology was that of a benign fibrous histiocytoma.

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  • [Cites] Dermatol Clin. 1999 Jul;17(3):487-505, vii [10410854.001]
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  • (PMID = 19675769.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721503
  • [Keywords] NOTNLM ; Benign / bladder / fibrous / histiocytoma
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85. Frau DV, Erdas E, Caria P, Ambu R, Dettori T, Faa G, Fletcher CD, Vanni R: Deep fibrous histiocytoma with a clonal karyotypic alteration: molecular cytogenetic characterization of a t(16;17)(p13.3;q21.3). Cancer Genet Cytogenet; 2010 Oct 1;202(1):17-21
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  • [Title] Deep fibrous histiocytoma with a clonal karyotypic alteration: molecular cytogenetic characterization of a t(16;17)(p13.3;q21.3).
  • Deep fibrous histiocytoma, a rare lesion occuring in deep soft tissues, has recently been formally characterized as a diagnostically distinguishable variant of the benign fibrous histiocytoma spectrum with distinct morphological features.
  • We report a 46,XY,t(16;17)(p13.3;q21.3) karyotype in a deep fibrous histiocytoma.
  • No break-apart signals were observed in the six additional cases studied, indicating either that the translocation is sporadic or that it is rare in deep fibrous histiocytoma.
  • In conclusion, our data show that chromosome aberrations may be found in deep fibrous histiocytoma and that, as with cutaneous lesions, they may have clonal, at present nonrecurrent, chromosome changes.
  • [MeSH-major] Chromosomes, Human, Pair 16. Chromosomes, Human, Pair 17. Histiocytoma, Benign Fibrous / genetics. Karyotyping / methods. Translocation, Genetic

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20804915.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin
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86. Barros PS, Safatle AM, Godoy CA, Souza MS, Barros LF, Brooks DE: Amniotic membrane transplantation for the reconstruction of the ocular surface in three cases. Vet Ophthalmol; 2005 May-Jun;8(3):189-92
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  • This paper describes the use of amniotic membrane in the reconstructive surgical repair of generalized keratomalacia, ankyloblepharon, and after fibrous histiocytoma removal in two dogs and a cat.
  • The mass was a fibrous histiocytoma localized to the sclera and cornea.

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  • (PMID = 15910372.001).
  • [ISSN] 1463-5216
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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87. Dettrick A, Strutton G: Atypical fibroxanthoma with perineural or intraneural invasion: report of two cases. J Cutan Pathol; 2006 Apr;33(4):318-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma with perineural or intraneural invasion: report of two cases.
  • We report two cases of atypical fibroxanthoma (AFX) that both had the previously unreported feature of neural invasion (one perineural and the other intraneural).
  • Some authors would regard such cases as malignant fibrous histiocytoma (MFH) because of such deep extension; however, the concept of AFX as a superficial variant of MFH is outmoded--AFX is a distinct clinicopathologic entity with established clinical, histological, and immunohistochemical features.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Neurons / pathology

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  • (PMID = 16630185.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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88. Arora R, Monga S, Mehta DK, Raina UK, Gogi A, Gupta SD: Malignant fibrous histiocytoma of the conjunctiva. Clin Exp Ophthalmol; 2006 Apr;34(3):275-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant fibrous histiocytoma of the conjunctiva.
  • Fibrous histiocytomas are mesenchymal tumours composed of cells with fibroblastic to histiocytic differentiation.
  • To date, there are 18 cases of fibrous histiocytoma arising from the corneoscleral limbus reported in the literature.
  • Eleven of these were classified as benign, and the rest were malignant fibrous histiocytomas.
  • Benign fibrous histiocytomas have been reported in the orbit, eyelid, episclera and conjunctiva.
  • Malignant fibrous histiocytoma has been well described in the orbit, but rarely as a primary conjunctival tumour.
  • Herein, the clinicopathological features of a case of malignant fibrous histiocytoma are presented and its management with wide excision and cryotherapy followed by ocular reconstruction with amniotic membrane transplant is discussed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology

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  • (PMID = 16671910.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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89. Sachdev R, Sundram U: Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. J Cutan Pathol; 2006 May;33(5):353-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa.
  • BACKGROUND: Distinction between cellular fibrous histiocytomas (FHs) with a deep component and dermatofibrosarcoma protuberans (DFSPs) can pose diagnostic problems.
  • Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa.
  • [MeSH-major] Antigens, CD / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Biomarkers, Tumor / analysis. Dermatofibrosarcoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Receptors, Cell Surface / biosynthesis. Skin Neoplasms / diagnosis

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  • (PMID = 16640542.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; EC 2.3.2.13 / Factor XIIIa
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90. Xiong Y, Guo H, Zhang S, Zhang B, Li T: [Differences of the molecular phenotypes and the histogenesis between dermatofibroma and dermatofibrosarcoma protuberans]. Beijing Da Xue Xue Bao; 2008 Aug 18;40(4):395-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differences of the molecular phenotypes and the histogenesis between dermatofibroma and dermatofibrosarcoma protuberans].
  • OBJECTIVE: To explore the histogenesis and differentiation of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP).
  • DF is a benign tumor, while DFSP a low grade malignant tumor.
  • [MeSH-major] Antigens, CD34 / metabolism. Dermatofibrosarcoma / genetics. Factor XIIIa / metabolism. Histiocytoma, Benign Fibrous / genetics

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  • (PMID = 18677387.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.3.2.13 / Factor XIIIa
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91. Song YS, Park CK: Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. Am J Dermatopathol; 2007 Jun;29(3):309-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma.
  • [MeSH-major] Cysts / pathology. Epithelium / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 17519635.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Macarenco AC, Macarenco RS: Reparative perineural hyperplasia and dermatofibroma. Am J Dermatopathol; 2010 Jun;32(4):409-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reparative perineural hyperplasia and dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Am J Dermatopathol. 2009 Feb;31(1):50-2 [19155725.001]
  • (PMID = 20010401.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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93. Berk DR, Lind AC, Tapia B, Kane AA, Bayliss SJ: Atypical fibroxanthoma in a child without xeroderma pigmentosum. Pediatr Dermatol; 2007 Jul-Aug;24(4):450-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma in a child without xeroderma pigmentosum.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology


94. Pratibha R, Ahmed S: Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. Int J Paediatr Dent; 2006 Sep;16(5):363-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomatoid variant of fibrous histiocytoma: a case report and review of literature.
  • Fibrous histiocytomas by themselves are not very common in the head and neck region.
  • Apart from considering the above fact, this report describes a unique and relatively rare variant of the neoplasm - the angiomatoid fibrous histiocytoma (AFH) which has a characteristic appearance and predilection for young individuals that occurred in the left lower border of the mandible in a 13-year-old girl.
  • Angiomatoid fibrous histiocytoma is a distinct fibrohistiocytic tumour of children and young adults that combines features of both fibrohistiocytic and vascular neoplasm.
  • It is considered to be a tumour of intermediate malignancy because of its less aggressive course in contrast to the conventional malignant fibrous histiocytoma.

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  • (PMID = 16879335.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 35
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95. Tronnier M, Vogelbruch M: Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31. J Cutan Pathol; 2007 Dec;34 Suppl 1:58-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31.
  • The occurrence of an atypical fibroxanthoma in association with a syringocystadenoma papilliferum is reported.

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  • (PMID = 17997741.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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96. Labonte S, Hanna W, Bandarchi-Chamkhaleh B: A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma. J Cutan Pathol; 2007 Nov;34(11):857-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma.
  • Cellular dermatofibroma (CDF) can mimic DFSP, but typical cases are easily differentiated from DFSP by their staining pattern for CD34 and factor 13a.
  • [MeSH-major] Dermatofibrosarcoma / metabolism. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism


97. Farhi D, De Lacerda D, Palangié A, Dupin N, Wallach D: Burgeoning nodule on the scalp of a 65-year-old man. Atypical fibroxanthoma (AFX). Arch Dermatol; 2007 May;143(5):653-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Burgeoning nodule on the scalp of a 65-year-old man. Atypical fibroxanthoma (AFX).
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 17515519.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Nguyen TT, Schwartz EJ, West RB, Warnke RA, Arber DA, Natkunam Y: Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. Am J Surg Pathol; 2005 May;29(5):617-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Staining for CD163 was seen in Rosai-Dorfman disease (5 of 6), histiocytic sarcoma (3 of 4), littoral cell angioma (6 of 6), and Langerhans cell histiocytosis (3 of 5).
  • A subset of atypical fibrous histiocytomas (9 of 16), benign fibrous histiocytomas (6 of 9), and atypical fibroxanthomas (1 of 3) also showed CD163 staining.
  • Our studies also confirm earlier work showing that CD163 is expressed in acute myeloid leukemia with monocytic differentiation (AML, FAB subtype M5) (2 of 6), as well as a majority of giant cell tenosynovial tumors (7 of 8).

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  • (PMID = 15832085.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / NIH CA34233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / Receptors, Cell Surface
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99. Quigley BC, Ricciuti J, Morgan MB: Amyloid light chain deposition associated with dermatofibroma: serendipity or association? Am J Dermatopathol; 2010 May;32(3):298-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amyloid light chain deposition associated with dermatofibroma: serendipity or association?
  • In contrast, secondary cutaneous amyloidosis is related to lesions such as squamous cell carcinoma, Bowen disease, basal cell carcinoma, and discoid lupus erythematosus, and has been shown in most cases to be derived from keratin epithelial elements.
  • Herein, we present a unique case of nodular amyloidosis occurring in association with a cellular dermatofibroma.
  • [MeSH-major] Amyloid / metabolism. Histiocytoma, Benign Fibrous / pathology. Immunoglobulin Light Chains / metabolism. Skin Neoplasms / pathology

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  • (PMID = 20110798.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid; 0 / Immunoglobulin Light Chains
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100. Botrus G, Sciot R, Debiec-Rychter M: Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly. Cancer Genet Cytogenet; 2006 Jan 15;164(2):155-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly.
  • We report a case of a 39-year-old woman with a recurrent aneurysmal fibrous histiocytoma of the right lower leg.
  • Our case highlights the importance of distinguishing this recurrent but benign lesion from similarly appearing malignant skin tumors.
  • [MeSH-major] Chromosomes, Human, Pair 19. Chromosomes, Human, Pair 22. Histiocytoma, Benign Fibrous / genetics. Skin Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 16434321.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ETS translocation variant 6 protein; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-ets; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / proto-oncogene protein bcl-3
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