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1. Vijayalakshmi P, Jethani J, Kim U: Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor. Indian J Ophthalmol; 2006 Jun;54(2):123-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor.
  • We report a case of this rare syndrome associated with an adjacent sinus tumor.
  • [MeSH-major] Oculomotor Muscles / pathology. Orbital Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Fibrosis / congenital. Fibrosis / etiology. Fibrosis / pathology. Humans. Infant. Magnetic Resonance Imaging

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  • (PMID = 16770032.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient.
  • Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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3. Gil Z, Abergel A, Leider-Trejo L, Khafif A, Margalit N, Amir A, Gur E, Fliss DM: A comprehensive algorithm for anterior skull base reconstruction after oncological resections. Skull Base; 2007 Feb;17(1):25-37

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred nine patients who had undergone 120 anterior skull base resections of tumors (52 malignant [43%], 68 benign [57%]) via the subcranial approach were studied.
  • A split calvarial bone graft, posterior frontal sinus wall, or three-dimensional titanium mesh were used when the tumor involved the frontal, nasal, or orbital bones.
  • A temporalis muscle flap was used to cover the orbital socket for cases of eye globe exenteration, and a rectus abdominis free flap was used for subcranial-orbitomaxillary resection.
  • We describe a simple and effective method of anterior skull base reconstruction after resections of both malignant and benign tumors.

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  • (PMID = 17603642.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852574
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4. Murthy R, Honavar SG: Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1. J AAPOS; 2009 Feb;13(1):97-8
MedlinePlus Health Information. consumer health - Usher Syndrome.

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  • [Title] Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1.
  • Vasoproliferative retinal tumors are benign tumors of unknown origin that generally affect healthy persons between their fourth and sixth decades and may lead to severe vision loss as a result of intraretinal hemorrhages and exudates.
  • We describe a case of unilateral vasoproliferative retinal tumor associated with retinitis pigmentosa in a patient with Usher syndrome type 1.

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  • (PMID = 19022692.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR: Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol; 2008 Mar 24;180(6):1277-89
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  • [Title] Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1.
  • Tumor cells undergo epithelial-to-mesenchymal transition (EMT) to convert from a benign to a malignant phenotype.
  • We have shown that human pancreatic cancer cells respond to collagen by up-regulating N-cadherin, which promotes tumor growth, invasion, and metastasis.
  • Initial characterization showed that knocking down c-Jun NH2-terminal kinase prevented N-cadherin up-regulation and limited tumor growth and invasion in a mouse model for pancreatic cancer.

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  • (PMID = 18362184.001).
  • [ISSN] 1540-8140
  • [Journal-full-title] The Journal of cell biology
  • [ISO-abbreviation] J. Cell Biol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01-GM51188; United States / NIDCR NIH HHS / DE / R01-DE12308; United States / NIDCR NIH HHS / DE / R01 DE012308; United States / NCI NIH HHS / CA / P30 CA036727; United States / NCI NIH HHS / CA / P30 CA36727; United States / NIGMS NIH HHS / GM / R01 GM051188
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCAR1 protein, human; 0 / Cadherins; 0 / Collagen Type I; 0 / Crk-Associated Substrate Protein; 0 / Integrin alpha2beta1; 0 / Receptors, Mitogen; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / discoidin receptor; EC 2.7.10.2 / Focal Adhesion Kinase 2; EC 2.7.10.2 / Focal Adhesion Protein-Tyrosine Kinases; EC 3.6.5.2 / rap1 GTP-Binding Proteins
  • [Other-IDs] NLM/ PMC2290851
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6. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • In conclusion, we demonstrate downregulation of alphaB-crystallin expression in highly dedifferentiated ATCs because of a tumor-specific transcription factor pattern.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Regulation, Neoplastic. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics. Protein Kinases / genetics. Repressor Proteins / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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7. Dériot JB, Ledoux-Pilon A, Pilon F, Ravel A, Déchelotte P, Rigal D, Chiambaretta F: [Solitary fibrous tumor of the orbit: an unusual cause of unilateral proptosis. Case report with a review of the literature]. J Fr Ophtalmol; 2005 Nov;28(9):999-1005

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solitary fibrous tumor of the orbit: an unusual cause of unilateral proptosis. Case report with a review of the literature].
  • [Transliterated title] Tumeur fibreuse solitaire de l'orbite: une cause inhabituelle d'exophtalmie unilatérale. A propos d'un cas avec revue de la littérature.
  • BACKGROUND: The solitary fibrous tumor (SFT) is a spindle-cell tumor that very rarely involves the orbit.
  • CASE: A 72-year-old woman presented a conjunctival inflammation of the right eye developing over 5 months with progressive proptosis.
  • Histological examination of the lesion removed by anterior orbitotomy confirmed the diagnosis of the SFT of the orbit.
  • DISCUSSION: The diagnosis of SFT is histological.
  • It is a mesenchymal tumor.
  • Immunohistochemically, the tumor cells are strongly positive for CD34 and vimentin.
  • CONCLUSION: The SFT of the orbit is a very rare and generally benign tumor.
  • [MeSH-major] Exophthalmos / etiology. Orbital Neoplasms / complications

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  • (PMID = 16395228.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 36
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8. Andrei S, Zemba M, Bratulescu M, Dobrescu N, Cucu B, Popescu A, Cuzino D, Curea M: [Cataract surgery in an eye with intraocular tumor]. Oftalmologia; 2005;49(4):41-6
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  • [Title] [Cataract surgery in an eye with intraocular tumor].
  • [Transliterated title] Consecintele efectuării operatiei de cataractă pe un ochi cu tumoră intraoculară--caz clinic.
  • This case present the consequences of performing the cataract surgery on an eye with intraocular tumor, pointing the importance of a detailed and complete examination, even for the benign and easy to diagnostic diseases.
  • [MeSH-major] Cataract Extraction. Choroid Neoplasms / diagnosis. Eye / pathology. Melanoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Eye Enucleation. Humans. Male. Middle Aged

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  • (PMID = 16524125.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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9. Shields JA, Eagle RC Jr, Shields CL, Brown GC, Lally SE: Malignant transformation of congenital hypertrophy of the retinal pigment epithelium. Ophthalmology; 2009 Nov;116(11):2213-6
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  • METHODS: A 56-year-old black woman was referred for an asymptomatic fundus lesion in her left eye.
  • It had features typical of CHRPE, but there was a small elevated nodule within the flat component, and the diagnosis was adenoma of the retinal pigment epithelium (RPE) arising from CHRPE.
  • Thirteen years after the initial diagnosis, the patient returned with severe visual loss and no view of the fundus resulting from cataract and posterior synechia.
  • Ultrasonography revealed a total retinal detachment and a pedunculated tumor measuring 7.5 mm in thickness.
  • The eye was enucleated and studied histopathologically.
  • MAIN OUTCOME MEASURES: Clinical evaluation and correlation of clinical findings with histopathologic results of the enucleated eye.
  • RESULTS: Histopathologically, the mass was composed of a proliferation of atypical RPE cells with a marked infiltration of benign plasma cells.
  • Typical features of CHRPE were present at the base of the tumor.
  • The final diagnosis was adenocarcinoma arising from CHRPE.
  • CONCLUSIONS: Congenital hypertrophy of the retinal pigment epithelium, once considered to be a benign and stationary lesion, may spawn a malignant neoplasm.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Transformation, Neoplastic / pathology. Retinal Neoplasms / pathology. Retinal Pigment Epithelium / pathology
  • [MeSH-minor] Eye Enucleation. Female. Humans. Hypertrophy / congenital. Middle Aged. Retinal Detachment / pathology. Retinal Detachment / ultrasonography

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  • (PMID = 19744732.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Burduk PK, Seredyka-Burduk M, Olejarz E: [Giant tumor of the orbit--a case of hidradenoma]. Otolaryngol Pol; 2007;61(6):1017-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant tumor of the orbit--a case of hidradenoma].
  • The most common symptoms are ophthalmology dysfunction as: exophthalmus, eye movement dysfunction and visual loss.
  • More often a benign lesions is found than malignant.
  • We present a case of 62 years old man with large expansion of benign tumor of the orbit with exophthalmus, eye movement disability and complete blindness.
  • Histopathology described a very rare tumor of the orbit-hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Orbital Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18546956.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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11. Li Y, Zhang TM, An YZ, Shi JT, Fu JD, Qiu E: [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae]. Zhonghua Yi Xue Za Zhi; 2006 Jun 20;86(23):1597-9
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  • [Title] [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae].
  • OBJECTIVE: To investigate the clinical manifestations of lacrimal gland tumor involving the anterior and middle cranial fossae and the effect of transcranial-orbital approach in treatment of such tumor.
  • METHODS: A retrospective study was conducted on the clinical data of 23 cases lacrimal gland tumor involving the anterior and middle cranial fossae confirmed by radiological examination, including 11 cases of adenoid cystic carcinoma, 6 cases of pleomorphic adenocarcinoma (malignant mixed tumor), 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma, 1 case of ductal carcinoma, 1 case of mucoepidermoid carcinoma, and 1 case of benign mixed tumor, 15 males and 8 females, aged 42.5 (2 - 76), with a case history of 43 months (2 months to 27 years), with the chief complaints of progressive proptosis, disgenesia of the eye ball, and orbit pain, all undergoing transcranial-orbital operation from August 1998 to February. 2006.
  • Recurrence of tumor occurred in 4 cases, and 1 case died from distant metastasis of adenocarcinoma.
  • Adequate orbital apex decompression and exposure of the tumor can result from suitable transcranial-orbital approach.
  • However, complete surgical excision is difficult, and the tumor has a tendency to recur post-operatively.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Skull Base Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cranial Fossa, Anterior. Cranial Fossa, Middle. Craniotomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 16854296.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. Warga M, Szurman P, Rohrbach JM: [Tumor of the caruncle of uncertain malignancy]. Klin Monbl Augenheilkd; 2005 Sep;222(9):733-5
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  • [Title] [Tumor of the caruncle of uncertain malignancy].
  • CASE REPORT: A sixty year old woman presented with a tumor of the caruncle that had persisted for one year.
  • Physical examination disclosed an indolent, tight elastic, highly vascularizated tumor.
  • Therefore to exclude a malignant process an excisional biopsy should always be performed even so in general tumors of the caruncle are benign.
  • In only 4 % of the cases oncocytomas are found even the oncocytoma is considered to be a typical tumor of the caruncle.
  • [MeSH-major] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / pathology. Eye Neoplasms / classification. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16175484.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Deng A, Petrali J, Jaffe D, Sina B, Gaspari A: Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol; 2005 Oct;27(5):432-5
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  • [Title] Benign cutaneous pseudoglandular schwannoma: a case report.
  • Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion.
  • There are also a few reported cases in the literature of pseudoglandular schwannoma from central nervous system, eye, submandible, and shoulder, in which the gland-like structures were lined by Schwann cells.
  • We report here a patient with a benign cutaneous schwannoma composed of predominantly gland-like spaces that contained mucinous material and were lined by Schwann cells confirmed by immunohistochemistry and ultrastructural studies.
  • The tumor was well circumscribed and showed minimal cytologic atypia, indicating benignity.
  • We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphologic diversity of schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16148415.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Noël G, Bollet MA, Calugaru V, Feuvret L, Haie-Meder C, Dhermain F, Ferrand R, Boisserie G, Beaudré A, Mazeron JJ, Habrand JL: Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys; 2005 Aug 1;62(5):1412-22
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  • [Title] Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons.
  • PURPOSE: To evaluate efficacy and tolerance of external fractionated combination of photon and proton radiation therapy (RT) for intracranial benign meningiomas.
  • One hundred eight eye-related symptoms were collected; 80 other symptoms were noted and followed up.
  • Out of the 108 eye-related symptoms, 106 (96%) were evaluated.
  • Stabilization of the tumor was observed in 38 cases (72%), volume reduction in 10 cases (20%), and intratumor necrosis in 3 cases.
  • [MeSH-major] Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy. Photons / therapeutic use. Protons / therapeutic use. Radiotherapy, Conformal / methods. Visual Acuity

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  • (PMID = 16029801.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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15. Siepmann K, Wannke B, Neumann D, Rohrbach JM: Subcutaneous tumor of the lower eyelid: a potential manifestation of a Dirofilaria repens infection. Eur J Ophthalmol; 2005 Jan-Feb;15(1):129-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subcutaneous tumor of the lower eyelid: a potential manifestation of a Dirofilaria repens infection.
  • PURPOSE: To report a case of Dirofilaria repens presenting as a subcutaneous tumor of the lower eyelid.
  • RESULTS: A 29-year-old man of Greek origin without systemic symptoms presented with a 3-week history of a small painless mass localized in the medial part of the lower eyelid.
  • CONCLUSIONS: Infection with the nematode Dirofilaria repens has to be considered in the differential diagnosis of malignant and benign tumors of subcutaneous periocular tissues in patients who traveled to endemic areas.
  • [MeSH-major] Dirofilaria / isolation & purification. Dirofilariasis / diagnosis. Eye Infections, Parasitic / diagnosis. Eyelid Diseases / diagnosis. Eyelid Neoplasms / diagnosis. Skin Diseases, Parasitic / diagnosis
  • [MeSH-minor] Adult. Animals. Diagnosis, Differential. Humans. Male

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  • (PMID = 15751252.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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16. Kim HJ, McCormick SA, Nath S, Moskowitz B, Milman T: Melanocytic nevi of the tarsal conjunctiva: clinicopathologic case series with review of literature. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):438-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009.
  • Biopsy, therefore, is prudent as histopathology alone allows documentation of the benign nature of these lesions.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Eyelid Neoplasms / pathology. Nevus, Pigmented / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20683369.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Perlmann E, da Silva EG, Guedes PM, Barros PS: Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat. Vet Ophthalmol; 2010 Jan;13(1):63-6
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  • [Title] Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat.
  • A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye.
  • Ophthalmic examination revealed a blind right eye and presence of two distinct masses: a pink and a red-to-brown mass, the latter occupying most of the cornea and part of the conjunctiva.
  • Exenteration was performed under general anesthesia, and the ocular tissues were processed routinely for histopathology.
  • Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea.
  • Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
  • A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made.
  • To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Cat Diseases / pathology. Eye Neoplasms / veterinary. Hemangioma / veterinary. Neoplasms, Multiple Primary / veterinary

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  • (PMID = 20149179.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Morris DS, Fayers T, Dolman PJ: Orbital teratoma: case report and management review. J AAPOS; 2009 Dec;13(6):605-7
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  • We present a case of benign mature orbital teratoma in a neonatal boy that involved the chiasmal area and cavernous sinus and displaced the nasopharynx.
  • A debulking procedure, mainly of the cystic parts of the tumor, was performed.
  • The patient remains stable at 3 years of age, with no further growth of the tumor and good vision in the affected eye.

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  • (PMID = 20006828.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Nichols KE, Walther S, Chao E, Shields C, Ganguly A: Recent advances in retinoblastoma genetic research. Curr Opin Ophthalmol; 2009 Sep;20(5):351-5
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  • PURPOSE OF REVIEW: Retinoblastoma is a pediatric eye tumor that serves as a paradigm for understanding the genetic basis of cancer.
  • RECENT FINDINGS: Current data demonstrate that retinomas, benign retinal tumors found in some retinoblastoma patients, exhibit bi-allelic mutations in RB1, the retinoblastoma gene, and lack of expression of the retinoblastoma protein.
  • [MeSH-major] Retinal Neoplasms / genetics. Retinoblastoma / genetics

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  • (PMID = 19587599.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01CA118580-01A2; United States / NCI NIH HHS / CA / R21 CA123196-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
  • [Number-of-references] 46
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20. Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS: Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi. Ophthalmology; 2007 Apr;114(4):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.
  • METHODS: Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds.
  • MAIN OUTCOME MEASURES: Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma.
  • No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF.
  • Seven out of 10 siblings had a history of cutaneous and/or ocular nevi.
  • Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma).
  • Three of the 10 siblings had relevant ocular findings (2 choroidal nevi, 1 uveal melanoma).
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Pedigree. Risk Factors. Sequence Analysis, DNA. Surveys and Questionnaires. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17207529.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p14ARF
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21. Song JJ, Finger PT, Kurli M, Wisnicki HJ, Iacob CE: Giant secondary conjunctival inclusion cysts: a late complication of strabismus surgery. Ophthalmology; 2006 Jun;113(6):1049.e1-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient's ocular history, ophthalmic examinations, and imaging (ultrasound/ultrasound biomicroscopy and/or computed tomography) were recorded.
  • Histopathologic evaluations were consistent with benign inclusion cysts of the conjunctiva.
  • Tumor size, cystic nature, and involvement of underlying structures can be determined by ultrasonography and radiographic imaging.

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  • (PMID = 16631253.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.
  • [MeSH-minor] Adult. Aged. Child. Eye Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Retrospective Studies

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Tang DR, Shi XF, Sun FY, Zhao H, Jin YJ: [Clinical features and therapy of benign lymphoepithelial lesion]. Zhonghua Yan Ke Za Zhi; 2009 May;45(5):441-5
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  • [Title] [Clinical features and therapy of benign lymphoepithelial lesion].
  • OBJECTIVE: To report the clinical features of benign lymphoepithelial lesion and to further characterize recommendations for its therapy strategy.
  • Retrospective analyze the clinical characteristics, imaging features, pathological manifestation and the treatment effect from the clinical materials of 9 cases of patients with benign lymphoepithelial lesion presenting to Tianjin Eye Hospital from Jan 2006 to Dec 2007.
  • RESULTS: The 9 cases, in which 7 cases were female, 7 cases had lesions on both eyes, demonstrated unpainful swelling of the lacrimal glands and in different degree of salivary glands or had history of tumor resection of salivary glands.
  • Three patients were operated to excise the lacrimal gland masses due to imperfect treatment effect of medication or in order to make definite diagnosis.
  • The postoperative pathological results supported the diagnosis of benign lymphoepithelial lesion.
  • CONCLUSIONS: A clinical condition with swelling of either or both lacrimal gland and of any salivary gland, and accompanied with systemic relative diseases should be considered benign lymphoepithelial lesion.
  • Imaging examinations are helpful to definite diagnosis.
  • The definite diagnosis should be made through pathological examinations.
  • [MeSH-major] Mikulicz' Disease / diagnosis. Mikulicz' Disease / drug therapy

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  • (PMID = 19576068.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glucocorticoids
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24. de Silva DJ, Tay E, Rose GE: Schwannomas of the lacrimal gland fossa. Orbit; 2009;28(6):433-5
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  • PURPOSE: Schwannomas are rare benign nerve sheath tumours that account for 1% of orbital tumours and, although sometimes associated with neurofibromatosis, most occur as isolated lesions and arise from branches of the ciliary or trigeminal nerves.
  • On a presumptive preoperative diagnosis of pleomorphic adenoma, the patient underwent a bone-swinging lateral orbitotomy with intact excision of a moderately-firm, lobulated lesion which proved to be a Schwannoma.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 19929679.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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25. Lu-Emerson C, Plotkin SR: The Neurofibromatoses. Part 1: NF1. Rev Neurol Dis; 2009;6(2):E47-53
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  • [Title] The Neurofibromatoses. Part 1: NF1.
  • NF1 is the most common neurogenetic disorder, with a birth incidence of 1 in 3000.
  • The hallmark lesion of NF1 is the neurofibroma, a benign tumor derived from the nerve sheath and composed of a mixture of proliferating Schwann cells, fibroblasts, mast cells, and pericytes.
  • [MeSH-major] Bone and Bones / pathology. Nervous System / pathology. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Skin / pathology
  • [MeSH-minor] Brain / pathology. Brain / physiopathology. Cafe-au-Lait Spots / genetics. Cafe-au-Lait Spots / pathology. Cafe-au-Lait Spots / physiopathology. Eye / pathology. Eye / physiopathology. Genes, Tumor Suppressor / physiology. Humans. Neurofibromatoses / genetics. Neurofibromatoses / pathology. Neurofibromatoses / physiopathology. Peripheral Nervous System / pathology. Peripheral Nervous System / physiopathology

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  • (PMID = 19587630.001).
  • [ISSN] 1949-4378
  • [Journal-full-title] Reviews in neurological diseases
  • [ISO-abbreviation] Rev Neurol Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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26. Ayberk G, Ozveren MF, Uzum N, Tosun O, Akcay EK: Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. Neurosurgery; 2008 Oct;63(4):E813-4; discussion E814
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  • Schirmer's test revealed decreased tear secretion in the right eye.
  • It was thought that the schwannoma in our patient originated from the greater superficial petrosal nerve, based on the location of the tumor in addition to the absence of partial Horner's syndrome and a persistent decrease in tear secretion.
  • INTERVENTION: The tumor was exposed with the use of a right subtemporal extradural approach and removed entirely.
  • Pathological evaluation of the tumor revealed a CS.
  • No adjuvant treatment was applied because of the tumor's benign character.
  • The greater superficial petrosal nerve schwannoma should be considered in the differential diagnosis of the abducens nerve palsy and petrous apex mass.

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  • (PMID = 18981849.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Boulos PR, Knoepp SM, Rubin PA: Green bone. Arch Ophthalmol; 2007 Mar;125(3):380-6
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  • OBJECTIVE: To describe the unusual finding of yellow-green-colored bone during routine orbital surgery, to detail its investigation, and to demonstrate its benign nature.
  • RESULTS: Yellow-green bone was encountered in 3 patients during orbital tumor excision or orbital fracture repair procedures.
  • In all cases, absence of neoplasia was demonstrated histologically.
  • [MeSH-minor] Adult. Color. Humans. Male. Microscopy, Fluorescence. Microscopy, Ultraviolet. Middle Aged. Orbital Fractures / surgery. Orbital Neoplasms / radiography. Orbital Neoplasms / surgery. Spectrophotometry, Ultraviolet. Tomography, X-Ray Computed

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  • (PMID = 17353410.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Synthesis Inhibitors; F8VB5M810T / Tetracycline
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28. Arora R, Monga S, Mehta DK, Raina UK, Gogi A, Gupta SD: Malignant fibrous histiocytoma of the conjunctiva. Clin Exp Ophthalmol; 2006 Apr;34(3):275-8
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  • They can occur in any part of the body including the orbital tissues.
  • Eleven of these were classified as benign, and the rest were malignant fibrous histiocytomas.
  • Benign fibrous histiocytomas have been reported in the orbit, eyelid, episclera and conjunctiva.
  • Malignant fibrous histiocytoma has been well described in the orbit, but rarely as a primary conjunctival tumour.
  • The rarity of the tumour makes its diagnosis and management a challenge.
  • Herein, the clinicopathological features of a case of malignant fibrous histiocytoma are presented and its management with wide excision and cryotherapy followed by ocular reconstruction with amniotic membrane transplant is discussed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 16671910.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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29. Demirci H, Shields CL, Eagle RC Jr, Shields JA: Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):402-4
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  • [Title] Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl.
  • A 16-year-old girl presented with diplopia and gradual-onset, painless proptosis of the left eye.
  • Five years later, her symptoms recurred, and she was referred to the Oncology Service, Wills Eye Institute.
  • Histopathologic examination showed benign, patternless spindle-cell proliferation with prominent intrinsic vascularity and multinucleated giant cells, consistent with giant cell angiofibroma, a variant of solitary fibrous tumor.
  • Giant cell angiofibroma, a variant of solitary fibrous tumor, is a rare orbital tumor that presents as a well-circumscribed, enhancing mass and can be found in children.
  • [MeSH-major] Angiofibroma / pathology. Giant Cell Tumors / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adolescent. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Diplopia / diagnosis. Exophthalmos / diagnosis. Female. Humans. Magnetic Resonance Imaging. Ophthalmologic Surgical Procedures

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  • (PMID = 19966660.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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30. Broggi M, Darbar A, Teo C: The value of endoscopy in the total resection of pineocytomas. Neurosurgery; 2010 Sep;67(3 Suppl Operative):ons159-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A series of 15 patients (11 females, 4 males; mean age, 48 years) with histological diagnosis of pineocytoma were retrospectively reviewed.
  • The endoscope was used at various times throughout the case and consistently at the end to evaluate any possible residual tumor.
  • There was only one patient with permanent neurological deficit (disconjugate eye movements).
  • Two patients (13%) had transient poor sleep pattern, 5 patients (33%) had transient disconjugate eye movements, and 2 patients (13%) had transient short-term memory disturbance.
  • In 6 cases (40%), the endoscope was able to detect residual tumor located either behind the Vein of Galen or attached to the undersurface of the corpus callosum.
  • Residual tumor was then resected using a 30 degrees endoscope and dedicated angled endoscopic instruments.
  • With total removal of these histologically benign tumors patients may enjoy extended progression-free survival without adjuvant radiotherapy.
  • [MeSH-major] Brain Neoplasms / surgery. Endoscopy / methods. Neurosurgery / methods. Pineal Gland / surgery. Pinealoma / surgery. Ventriculostomy / methods

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  • (PMID = 20679933.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Yates CW, Weinberg M, Packer MJ, Jacob A: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. Ann Otol Rhinol Laryngol; 2010 Jun;119(6):402-5
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  • [Title] Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
  • Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve.
  • During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma.

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  • (PMID = 20583739.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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32. Paglia D, Dubielzig RR, Kado-Fong HK, Maggs DJ: Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms. Am J Vet Res; 2009 Oct;70(10):1284-90
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  • [Title] Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms.
  • OBJECTIVE: To determine whether cyclooxygenase-2 (COX-2) is expressed in benign or malignant canine uveal melanocytic neoplasms and whether expression correlates with malignancy.
  • SAMPLE POPULATION: Tissue sections from 71 globes; 57 with benign (n = 15), malignant (34), or mixed (8) uveal melanocytic neoplasms; 10 with nonneoplastic disease; and 4 with no abnormalities.
  • RESULTS: Expression of COX-2 was detected in all but 5 globes, all of which contained neoplasms.
  • Expression of COX-2 was detected in regions infiltrated by neoplasia in 21 globes; however, definitive labeling of tumor cells was detected in only 2 of those.
  • Expression of COX-2 was detected in the ciliary body of more globes with uveal malignant melanoma (20/34) than in those without disease (1/4), with nonneoplastic disease (4/10), or with melanocytoma (3/15) or mixed neoplasms (3/8).
  • CONCLUSIONS AND CLINICAL RELEVANCE: Canine globes with uveal melanocytic neoplasia appeared to express COX-2 in similar sites and with similar intensity as globes without neoplasia.
  • Differentiation of benign from malignant canine uveal melanocytic neoplasms was not possible.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Dog Diseases / metabolism. Eye Neoplasms / veterinary. Uvea / pathology

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  • (PMID = 19795944.001).
  • [ISSN] 0002-9645
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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33. Zhang CF, Dong FT, Chen YX, Du H, Han BL: [Clinical manifestation and follow-up of melanocytoma of the optic disc]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):296-300
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  • All cases were unilateral involved, 5 cases were right eye, 5 cases were left eye.
  • The distribution of the visual acuity was follows: light perception in 2 eyes, 20/200 in one eye, 20/20 or above in 7 eyes.
  • The tumor mass at the optic disc with extensive serous detachment of retina was detected on B-scan in one eye.
  • The benign melanocytoma was diagnosed by vitreous fine needle biopsy for this eye.
  • In other case, the tumor was found to be enlarged, visual field defect deteriorated, pigment granules appeared in the vitreous adjacent to the tumor during on year follow-up period.
  • On the patient request, enucleation was performed to rule out the malignancy of the tumor.
  • Pathologic study showed that the tumor cells were active, but benign state.
  • The tumor size and visual acuity in other eight eyes remained stable in the follow-up period with one to 18 years (mean 3.5 years).
  • On FFA and ICGA, bilateral choroidal nevi were found in one eye.
  • CONCLUSIONS: Melanocytoma of the optic disc is a benign tumor that rarely causes visual impairment.
  • However, visual acuity may be impaired due to enlargement of the tumor or necrosis in tumor.
  • [MeSH-major] Melanoma / diagnosis. Optic Disk / pathology. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choroid Neoplasms / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19575959.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Qian Y, Zakov ZN, Schoenfield L, Singh AD: Iris melanoma arising in iris nevus in oculo(dermal) melanocytosis. Surv Ophthalmol; 2008 Jul-Aug;53(4):411-5
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  • Benign nevus cells were present at the periphery of the tumor surrounding the entire melanoma.
  • [MeSH-major] Iris Neoplasms / pathology. Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology

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  • (PMID = 18572057.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Kinoshita S, Kakizaki H, Iwaki M, Hara K: [Two cases of dermolipoma]. Nippon Ganka Gakkai Zasshi; 2007 Dec;111(12):965-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Dermolipoma is an uncommon benign tumor, congenitally occurring on the conjunctiva, and may be present at other sites.
  • The appearance of dermolipoma closely resembles orbital fat prolapse and limbal dermoid, and therefore it is necessary to take this into account in diagnosis.
  • CASE REPORT: The first case was a 52-year-old female patient referred for the treatment of an orbital fat prolapse in her right eye.
  • Another case, an 8-year-old female patient, was referred for the treatment of a bulbar conjunctival tumor in her left eye.
  • In both cases, dermolipoma was suspected because the tumor did not show in the limbus and it did not change in size even when the eyeball was pressed.
  • CONCLUSIONS: If the special features of dermolipoma are understood, it is easy to distinguish this tumor from other disorders.
  • [MeSH-minor] Child. Conjunctival Neoplasms / congenital. Conjunctival Neoplasms / surgery. Female. Humans. Middle Aged

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  • (PMID = 18186219.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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36. Dégi R, Szabó A, Janáky M: [Experience in 13-year follow-up of a melanocytoma of the optic nerve head]. Magy Onkol; 2005;49(1):31-4
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  • Thirteen years ago, a 35-year-old woman was found on routine ocular examination to have a pigmented tumor in her right eye, adjacent to the optic nerve head.
  • Ultrasound examination revealed that the tumor diameter was 4.4 mm on the base and the maximal thickness was 2.7 mm.
  • There were several additional examinations (e.g. determination of the visual field, measurement of the intraocular pressure, detection of visually evoked potentials, CT scan and MRI examination) to exclude a benign tumor of similar appearance, The patient underwent ocular examination every year.
  • During the observation period a minor tumor enlargement occurred but there were no changes in the visual acuities.
  • The findings documented and illustrated here suggest that our methods were useful to differentiate the melanocytoma from a malignant melanoma, and no surgical interventions were needed to characterize or to remove the tumor.
  • [MeSH-major] Melanocytes. Melanoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fluorescein Angiography. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 15902331.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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37. Fichter N, Schittkowski M, Guthoff RF: [Diseases of the lacrimal gland]. Ophthalmologe; 2005 Apr;102(4):399-423; quiz 424-5
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  • Experience with the differential diagnosis of lacrimal gland illnesses is limited in daily practice due to their rarity.
  • It is therefore of particular importance to have guidelines for the practitioner by which he can decide on the application of conservative or surgical therapy, and whether it is necessary to take a biopsy to clarify the diagnosis.
  • There is a wide spectrum of possible illnesses which include systemic diseases, inflammatory disorders, neoplastic, benign and malignant tumors.
  • When a pleomorphic adenoma cannot be excluded, biopsy is contraindicated and complete tumor excision with its capsule is necessary to prevent the possibility of malignant transformation and a negative effect on long-term prognosis.
  • In this overview, special interest is placed on the typical clinical aspects and imaging features of lesions of the lacrimal gland fossa, their differential diagnosis and management.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Biopsy. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Lacrimal Apparatus / pathology. Practice Guidelines as Topic

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  • (PMID = 15782290.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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38. Tam ES, Chen EC, Nijhawan N, Harvey JT, Howarth D, Oestreicher JH: Solitary fibrous tumor of the orbit: a case series. Orbit; 2008;27(6):426-31

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  • [Title] Solitary fibrous tumor of the orbit: a case series.
  • PURPOSE: Solitary fibrous tumor (SFT) occurs rarely in the orbit.
  • We present four such cases, representing one of the largest case series reported to date of this rare orbital tumor.
  • METHOD: The four patients ranged from ages 20 to 50, all of whom presented with lid swelling or bulging in the involved eye.
  • All four patients underwent CT scan to confirm the diagnosis of an orbital mass, which was then excised.
  • One of these cases demonstrated residual tumor on follow-up CT scan, which remained unchanged at one-year follow-up.
  • No evidence of residual tumor was found in the other three cases, despite one having malignant pathology.
  • CONCLUSION: SFT is a rare and generally benign tumor of the orbit.
  • Immunohistochemical testing with CD34 is necessary to confirm the diagnosis.
  • Although en bloc tumor resection is the definitive treatment, residual tumor may remain stable for some time.
  • [MeSH-major] Fibroma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 19085297.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
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39. Popovic MB, Diezi M, Kuchler H, Abouzeid H, Maeder P, Balmer A, Munier FL: Trilateral retinoblastoma with suprasellar tumor and associated pineal cyst. J Pediatr Hematol Oncol; 2007 Jan;29(1):53-6
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  • [Title] Trilateral retinoblastoma with suprasellar tumor and associated pineal cyst.
  • Trilateral retinoblastoma (TRb) is a well-known syndrome associating hereditary retinoblastoma (Rb) with an intracranial neuroblastic tumor arising usually in the pineal region, rarely at the suprasellar or parasellar site.
  • It develops in most cases after diagnosis of Rb.
  • Pineal cysts have recently been reported as a benign variant of TRb.
  • We report the unusual presentation of a TRb in a 12-month-old boy with extensive bilateral Rb, a voluminous suprasellar tumor, pineal cyst, and leptomeningeal disease.
  • [MeSH-major] Central Nervous System Cysts / radiography. Eye Neoplasms / radiography. Meningeal Neoplasms / radiography. Pineal Gland / radiography. Retinoblastoma / radiography

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  • (PMID = 17230067.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 8N3DW7272P / Cyclophosphamide; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin
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40. Lavaju P, Arya SK, Sinha A, Pandey S, Adhikari S, Shrestha BG, Chetan S, Agarwal TL: Pattern of ocular tumors in the eastern region of Nepal. Nepal J Ophthalmol; 2009 Jan-Jun;1(1):9-12
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  • [Title] Pattern of ocular tumors in the eastern region of Nepal.
  • BACKGROUND: ocular tumors are commonly encountered in ophthalmic practice.
  • OBJECTIVE: to study the clinical pattern of ocular tumors in the eastern region of Nepal.
  • MATERIALS AND METHODS: the hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively.
  • RESULTS: of 115 consecutive patients with ocular tumors, 40 (34.75%) were below the age of 21 years, 41 (35.65%) were in the age group of 21-50 years and 34 (29.56%) of age above 50 years.
  • There were 48 (41.73%) and 67 (58.26%) patients with benign and malignant tumors respectively.
  • The common benign tumors were conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma.
  • Retinoblastoma was the most common ocular malignant tumor in the pediatric age group (88.8%).
  • CONCLUSION: conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma are common benign ocular tumors, whereas basal cell carcinoma and retinoblastoma are the commonest ocular malignancies in adults and children respectively.
  • [MeSH-major] Eye Neoplasms / epidemiology

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  • (PMID = 21141015.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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41. Yan XM, Chen Y, Li HL, Rong B, Yang SL: [Retrospective analysis of ocular cicatricial pemphigoid]. Zhonghua Yan Ke Za Zhi; 2010 Sep;46(9):781-4
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  • [Title] [Retrospective analysis of ocular cicatricial pemphigoid].
  • OBJECTIVE: To analyze the clinical characterization of ocular cicatricial pemphigoid (OCP).
  • It was two to five years from the first time to see a doctor to definite diagnosis.
  • All of cases have been prescribed antibiotic eye drops for a long times, one case has been undergone three times trichiasis operation and made the disease progression.
  • Only in 1 case, there was slight increase of iron protein as tumor mark.
  • [MeSH-major] Diagnostic Errors. Pemphigoid, Benign Mucous Membrane

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  • (PMID = 21092555.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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42. Soni CR, Kumar G, Sahota P, Miller DC, Litofsky NS: Metastases to Meckel's cave: report of two cases and comparative analysis of malignant tumors with meningioma and schwannoma of Meckel's cave. Clin Neurol Neurosurg; 2010 Dec;112(10):927-32
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  • We analyzed the symptoms, results of neurological and radiographic examination, pre-operative diagnosis and final diagnosis of these tumors.
  • RESULTS: Of the 21 patients with malignant tumor involving Meckel's cave, 76% (16/21) had pain, 67% (14/21) had paraesthesia, 89% (17/21) had objective evidence of trigeminal sensory involvement and 42% (8/21) had objective evidence of trigeminal motor involvement.
  • CONCLUSION: Subtle clinical clues may help differentiate malignant from benign involvement of Meckel's cave.
  • [MeSH-major] Meningioma / secondary. Meningioma / surgery. Neurilemmoma / secondary. Neurilemmoma / surgery. Skull Base Neoplasms / secondary. Skull Base Neoplasms / surgery. Temporal Bone / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Craniotomy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Nose Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20728984.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Netherlands
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43. Sojka P, Pogrzebielski A, Orłowska-Heitzman J, Romanowska-Dixon B: [Mesectodermal leiomyoma of the ciliary body--case report]. Klin Oczna; 2009;111(10-12):350-3

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  • MATERIAL AND METHODS: In the left eye of the 15 years old female patient presenting 2 months history of deterioration of visual acuity a medium-pigmented, dome-shaped tumor at the inferotemporal side was detected.
  • Due to the size of the tumor and the impossibility of conducting conservative treatment the globe was eventually enucleated.
  • RESULTS: The final diagnosis was established on the basis of histopathological microscopic examination and immunohistochemical stains.
  • CONCLUSIONS: Mesectodermal leiomyoma of the ciliary body is an extremely rare benign tumor, which originates from neural crests.
  • [MeSH-major] Ciliary Body / pathology. Leiomyoma / diagnosis. Uveal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Eye Enucleation. Female. Humans

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  • (PMID = 20169895.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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44. Livaoĝlu M, Cakir E, Karaçal N: Large orbital osteoma arising from orbital roof: Excision through an upper blepharoplasty incision. Orbit; 2009;28(2-3):200-2

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  • Osteoma is the most common benign tumor of facial bony structure.
  • The patient's ophtalmological examination revealed; only light perception due to the severe amblyopia and posterior capsular opacification in the right eye, and complete visual acuity in the left.
  • His left eye was proptotic and directed to downward lateral gaze position.
  • There were not any postoperative complications and all ocular symptoms in the left eye were resolved after 1 month.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Orbital Neoplasms / surgery. Osteoma / diagnosis. Osteoma / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoplasty / methods. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Ophthalmologic Surgical Procedures / methods. Risk Assessment. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19839914.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Soong T, Soong V, Salvi SM, Raynor M, Mudhar H, Goel S, Edwards M: Primary corneal myxoma. Cornea; 2008 Dec;27(10):1186-8
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  • These include an inferonasal location between the corneal epithelium and Bowman layer and with no relationship to the corneal stroma, rapid tumor growth over a 3-month period, and no previous ocular trauma or conjunctival pathology.
  • The histology of this lesion has an important part to play in the management of this condition as it determines the cellular origin, establishes a benign or malignant state, and helps with treatment and prognosis.
  • [MeSH-major] Corneal Diseases / pathology. Corneal Diseases / surgery. Eye Neoplasms / pathology. Eye Neoplasms / surgery. Myxoma / pathology. Myxoma / surgery

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  • (PMID = 19034139.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Kashkouli MB, Khalatbari MR, Yahyavi T, Borghei Razavi H, Shayanfar N, Parvaresh MM: Primary endo-orbital osteoid osteoma. Orbit; 2008;27(3):211-3

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  • Osteiod osteoma is a small, benign, osteoblastic tumor, which usually affects the long bone of the lower extremities and vertebrae.
  • A 22-year-old man presented with eyelid edema, proptosis and pain in the left eye 1 year after the beginning of the symptoms.
  • [MeSH-major] Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Osteoma, Osteoid / pathology. Osteoma, Osteoid / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Exophthalmos / diagnosis. Exophthalmos / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18569832.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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47. Danzig CJ, Shields CL, Mashayekhi A, Ehya H, Manquez ME, Shields JA: Fluorescein angiography of iris juvenile xanthogranuloma. J Pediatr Ophthalmol Strabismus; 2008 Mar-Apr;45(2):110-2
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  • A 3-year-old boy was referred because of the presence of a non-pigmented, highly vascular mass with tapioca appearance involving the superior portion of the left iris.
  • Iris fluorescein angiography revealed early hyperfluorescence of the iris tumor with diffuse, intense late leakage of dye throughout the entire iris, not just in the region of the tumor.
  • Cytopathologic examination revealed Touton giant cells and the presence of histiocytes, confirming the diagnosis of iris juvenile xanthogranuloma.
  • Fluorescein angiography may be useful in differentiating iris juvenile xanthogranuloma from malignant or non-inflammatory benign iris lesions.
  • [MeSH-major] Fluorescein Angiography. Iris Diseases / diagnosis. Xanthogranuloma, Juvenile / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Glucocorticoids / therapeutic use. Humans. Iris / blood supply. Male. Prednisolone / analogs & derivatives. Prednisolone / therapeutic use

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  • (PMID = 18404959.001).
  • [ISSN] 0191-3913
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 8B2807733D / prednisolone acetate; 9PHQ9Y1OLM / Prednisolone
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48. Berman EL, Shields CL, Sagoo MS, Eagle RC Jr, Shields JA: Multifocal blue nevus of the conjunctiva. Surv Ophthalmol; 2008 Jan-Feb;53(1):41-9
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  • Blue nevus is a congenital benign melanocytic tumor that classically occurs in the skin and carries low potential for malignant transformation.
  • A 55-year-old Hispanic woman was found to have multiple darkly pigmented lesions on her left eye.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Blue / pathology
  • [MeSH-minor] Biopsy. Cryosurgery / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Melanoma / diagnosis. Middle Aged

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  • (PMID = 18191656.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Currie ZI, Rose GE: Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol; 2007 Dec;125(12):1643-6
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  • METHODS: Medical records were reviewed for 133 patients and only those patients with 5 years or more of follow up were classified into the following 5 subgroups: those with intact excision (group IA, n = 46), those with surgically intact excision but areas of complete attenuation of the pseudocapsule at histologic analysis (group IB, n = 7), those with previous inadvertent incisional biopsy (group IIA, n = 9), those with breach of the pseudocapsule during attempted intact excision (group IIB, n = 5), and those undergoing definitive surgery because of tumor recurrence after previous incomplete excision (group III, n = 5).
  • RESULTS: Seventy-two patients were followed up longer than 5 years; there were no known tumor recurrences among 61 patients excluded with shorter follow-up.
  • Patients in groups IA and IB exhibited no tumor recurrences at 8.2 to 34.1 years of follow-up.
  • A benign recurrence occurred along the superior orbital fissure in 1 patient in group IIA 12(1/2) years after the initial surgery and was resected.
  • Long-term follow-up is, however, necessary when there has been tumor disruption, either inadvertently during previous biopsy or by capsular breach during definitive excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Eye Neoplasms. Female. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 18071115.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Shields CL, Shields JA: Conjunctival tumors in children. Curr Opin Ophthalmol; 2007 Sep;18(5):351-60

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  • Overall, 97% prove to be benign and only 3% are malignant.
  • SUMMARY: Conjunctival nevus is the most common conjunctival tumor in children and fewer than 1% evolve into melanoma over time.
  • [MeSH-major] Conjunctival Neoplasms / pathology

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  • (PMID = 17700226.001).
  • [ISSN] 1040-8738
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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51. Cordero Coma M, Yilmaz T, Foster CS: Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid. Acta Ophthalmol Scand; 2007 Nov;85(7):753-5
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  • [Title] Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid.
  • PURPOSE: The presence of tumour necrosis factor-alpha (TNF-alpha) in conjunctivae affected by ocular cicatricial pemphigoid (OCP) was investigated.
  • [MeSH-major] Conjunctiva / metabolism. Conjunctivitis, Allergic / metabolism. Pemphigoid, Benign Mucous Membrane / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17488321.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha
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52. Robinson JW, Brownstein S, Jordan DR, Hodge WG: Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol; 2006 Sep-Oct;51(5):513-9
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  • [Title] Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
  • The woman was undergoing mitomycin C injections for ocular cicatricial pemphigoid, diagnosed in the same eye 2 years prior to identification of the neoplasm.
  • The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology. Conjunctivitis / complications. Pemphigoid, Benign Mucous Membrane / complications
  • [MeSH-minor] Basement Membrane / pathology. Biopsy. Drug Therapy, Combination. Female. Fluorometholone / therapeutic use. Humans. Middle Aged. Mitomycin / therapeutic use. Neoplasm Invasiveness. Ofloxacin / therapeutic use


53. Kiratli H, Bulur B, Bilgiç S: Transconjunctival approach for retrobulbar intraconal orbital cavernous hemangiomas. Orbital surgeon's perspective. Surg Neurol; 2005 Jul;64(1):71-4
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  • BACKGROUND: Cavernous hemangioma is the most common benign intraorbital tumor found in adults.
  • The presumptive preoperative diagnosis was based on magnetic resonance imaging findings.
  • The tumor was exposed via a transconjunctival route after temporarily disinserting an extraocular muscle depending on the location of the lesion.
  • RESULTS: In all patients, the tumor was in touch with the globe and in most cases extended to the orbital apex.
  • This method is best for tumors whose anterior borders are in contact or very close to the eye even if the posterior border abuts the orbital apex.
  • [MeSH-major] Hemangioma, Cavernous / surgery. Neurosurgical Procedures / methods. Orbital Neoplasms / surgery

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  • [CommentIn] Surg Neurol. 2006 Mar;65(3):316; author reply 316 [16488268.001]
  • (PMID = 15993191.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Składzień J, Tomik J, Wiatr M: [Primary benign orbital tumors in experience of the Department of Otolaryngology Jagiellonian University]. Przegl Lek; 2006;63(11):1210-2

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  • [Title] [Primary benign orbital tumors in experience of the Department of Otolaryngology Jagiellonian University].
  • BACKGROUND: The important question in primary eye socket tumors surgery is total surgery and saving the patient's sight.
  • THE AIM OF THE STUDY: It was assessment of the data of primary non malignant tumor therapy in Cracovian Department of Otolaryngology.
  • In 118 cases primary benign orbital tumors were removed, in remaining patients tumors were malignant.
  • RESULTS: In all patients eyeball was preserved, even in 6 with optic nerve glioma.
  • [MeSH-major] Ophthalmologic Surgical Procedures. Orbital Neoplasms / surgery

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  • (PMID = 17348418.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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55. Igaki T, Pagliarini RA, Xu T: Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol; 2006 Jun 6;16(11):1139-46
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  • [Title] Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.
  • However, the underlying mechanisms of how cell polarity disruption contributes to tumor progression are unknown.
  • Here, using a Drosophila genetic model for Ras-induced tumor progression, we show a molecular link between loss of cell polarity and tumor malignancy.
  • Mutation of different apicobasal polarity genes activates c-Jun N-terminal kinase (JNK) signaling and downregulates the E-cadherin/beta-catenin adhesion complex, both of which are necessary and sufficient to cause oncogenic Ras(V12)-induced benign tumors in the developing eye to exhibit metastatic behavior.
  • Furthermore, activated JNK and Ras signaling cooperate in promoting tumor growth cell autonomously, as JNK signaling switches its proapoptotic role to a progrowth effect in the presence of oncogenic Ras.
  • Our finding that such context-dependent alterations promote both tumor growth and metastatic behavior suggests that metastasis-promoting mutations may be selected for based primarily on their growth-promoting capabilities.
  • [MeSH-major] Drosophila / enzymology. Drosophila Proteins / metabolism. JNK Mitogen-Activated Protein Kinases / metabolism. Neoplasms, Experimental / enzymology
  • [MeSH-minor] Animals. Apoptosis / genetics. Cadherins / metabolism. Cell Polarity / genetics. Disease Models, Animal. Enzyme Activation. Eye / pathology. Neoplasm Metastasis. Proto-Oncogene Proteins p21(ras) / metabolism. Signal Transduction. beta Catenin / metabolism

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  • (PMID = 16753569.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Drosophila Proteins; 0 / beta Catenin; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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56. Asadi Amoli F, Sina AH, Kasai A, Ayan Z: A well-known lesion in an unusual location: infantile myofibroma of the eyelid: a case report and review of literature. Acta Med Iran; 2010 Nov-Dec;48(6):412-6
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  • Myofibroma is a neoplasia of myofibroblasts that can be solitary or multiple and it is found most commonly in the head & neck region including scalp, forehead, parotid region and oral cavity.
  • It has a benign course in the solitary form and fatal in its multiple form.
  • A 4 month male infant referred to Farabi hospital -the referral center for eye diseases- with a 2 month history of a mass in his eyelid with gradual enlargement with no other complaints.
  • Its pattern of growth and architecture rules out the other differential diagnoses like nodular fasciitis, fibrous histiocytoma, infantile fibromatosis, and peripheral primitive neuroectodermal tumor, mesenchymal chondrosarcoma, malignant hemangiopericytoma, juvenile fibrosarcoma and poorly differentiated synovial sarcoma.

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  • (PMID = 21287484.001).
  • [ISSN] 1735-9694
  • [Journal-full-title] Acta medica Iranica
  • [ISO-abbreviation] Acta Med Iran
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Iran
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57. Ishijima K, Kase S, Noda M, Ishida S: [Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia]. Nippon Ganka Gakkai Zasshi; 2010 Dec;114(12):1036-9
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  • [Title] [Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia].
  • BACKGROUND: Pyogenic granuloma is a benign tumor presenting with a smooth hemorrhagic surface that develops on the ocular surface after trauma or ophthalmic surgery.
  • Abnormal wound healing due to physical and/or chemical stimulation may contribute to the pathogenesis of the tumor.
  • We herein report the usefulness of brushing cytology for diagnosis of pyogenic granuloma, which rapidly developed after surgical resection of corneal/conjunctial intraepithelial neoplasia (CIN).
  • CASE: A 70-year-old man presented with a flat tumor on the left lower conjunctiva in conjunction with the cornea.
  • The patient underwent excision of the tumor and cryotherapy.
  • The primary tumor was histologically diagnosed with CIN.
  • The secondary tumor was diagnosed as pyogenic granuloma.
  • CONCLUSIONS: It is possible to diagnose a secondary tumor based on information of the clinical course, slit-lamp examination and brushing cytology before the excision of CIN.
  • [MeSH-major] Carcinoma in Situ / surgery. Conjunctival Neoplasms / surgery. Corneal Diseases / surgery. Eye Neoplasms / surgery. Granuloma, Pyogenic / diagnosis. Granuloma, Pyogenic / etiology. Postoperative Complications
  • [MeSH-minor] Aged. Cytodiagnosis / methods. Diagnosis, Differential. Humans. Male

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  • (PMID = 21268819.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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58. Horowitz G, Gil Z, Kavel O, Smith D, Sela M, Abargel A, Fliss D: [Surgical treatment of maxillary tumors]. Harefuah; 2010 Nov;149(11):704-7, 749

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this article is to review the indications, diagnosis and treatment of patients with maxillary tumors operated at Tel Aviv Sourasky Medical Center during the period 1999 - 2008.
  • METHODS: A total of 174 patients underwent surgery due to neoplasms originating in the maxillary sinus: 118 patients (68%) had malignant and 54 (32%) had benign tumors.
  • RESULTS: The most common malignancy was squamous cell carcinoma (40%), and the most common benign tumor was juvenile nasopharyngeal angiofibroma (36%).
  • In 9 cases, resection was extended to include the eye socket or base of skull, due to tumor invasion.
  • [MeSH-major] Maxillary Neoplasms / surgery
  • [MeSH-minor] Angiofibroma / mortality. Angiofibroma / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Humans. Maxilla / surgery. Melanoma / mortality. Melanoma / surgery. Nasopharyngeal Neoplasms / mortality. Nasopharyngeal Neoplasms / surgery. Retrospective Studies. Sarcoma / mortality. Sarcoma / surgery. Survival Rate

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  • (PMID = 21250410.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] Nasopharyngeal carcinoma
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59. Karl A, Stepp H, Willmann E, Buchner A, Hocaoglu Y, Stief C, Tritschler S: Optical coherence tomography for bladder cancer -- ready as a surrogate for optical biopsy? Results of a prospective mono-centre study. Eur J Med Res; 2010 Mar 30;15(3):131-4
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  • INTRODUCTION: New modalities like Optical Coherence Tomography (OCT) allow non-invasive examination of the internal structure of biological tissue in vivo.
  • Of all analyzed lesions 88 were benign (inflammation, edema, hyperplasia etc.) and 14 were malignant (CIS, Ta, T1, T2) as shown by final histo?pathology.
  • Furthermore all invasive tumors were staged correctly by OCT regarding tumor growth beyond the lamina propria.
  • Sensitivity of OCT for detecting the presence of a malignant lesion was 100% and sensitivity for detection of tumor growth beyond the lamina propria was 100% as well.
  • CONCLUSION: As a minimally invasive technique, OCT proved to have extremely high sensitivity for detection of malignant lesions as well as estimation of whether a tumor has invaded beyond the lamina propria.
  • [MeSH-major] Cystoscopy. Tomography, Optical Coherence. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Prospective Studies. Sensitivity and Specificity. Young Adult

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  • [Cites] J Urol. 2000 Jun;163(6):1693-6 [10799162.001]
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  • (PMID = 20452899.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3352220
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60. Brovkina AF, Tadzhieva ZA, Sherstnev VV: [Clinical and epidemiological study of lacrimal neoplasms]. Vestn Oftalmol; 2009 May-Jun;125(3):3-8
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  • [Title] [Clinical and epidemiological study of lacrimal neoplasms].
  • A cross-sectional mass epidemiological survey of 18,320 urban and rural citizens of the Republic of Tadjikistan revealed 31 patients with orbital tumors, of which lacrimal neoplasms were determined in 4 (0.022% in the general population and 12.9% of the identified orbital tumors).
  • According to the referral data, the prevalence of lacrimal neoplasms was 1.03% of all the tumors of the organ of vision and 5.26% of the orbital neoplasms.
  • Epithelial tumors were more common (52%), their malignant forms dominated over benign ones (55.7% versus 44.3%).
  • Lymphoid tissue tumors (13.6%), cystoid masses (8.6%), and neoplasms of unclear genesis (1.4%) were noticeably less prevalent.
  • With the higher grade of anaplasia, the likelihood of a recurrence of a tumor and the rate of its growth increased (r = +0.83).
  • [MeSH-major] Eye Neoplasms / epidemiology. Lacrimal Apparatus
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Morbidity. Population Surveillance. Retrospective Studies. Tajikistan / epidemiology

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  • (PMID = 19566038.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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61. Hirschbein MJ, Collins S, Jean WC, Chang SD, Adler JR Jr: Treatment of intraorbital lesions using the Accuray CyberKnife system. Orbit; 2008;27(2):97-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: This retrospective, non-comparative, interventional case series included 16 patients (6 women and 10 men) with lesions located wholly within the orbit.
  • Thirteen cases involved tumors (31% benign and 69% malignant), two cases presented with chronic orbital inflammation and one patient had intraorbital tissue growth secondary to Graves disease.
  • The main outcome measures analyzed were change in tumor/neoplasm size, pain, visual field preservation and visual acuity, which were followed for up to 15 months.
  • RESULTS: Twelve patients had a postoperative MRI, which revealed either a decrease or stabilization of tumor size.
  • In the five lymphoma cases there was complete disappearance of the tumor.
  • CONCLUSIONS: Staged CyberKnife radiosurgery is an effective option for the treatment of intraorbital lesions that controls tumor size, relieves pain, and preserves vision.
  • [MeSH-major] Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Radiosurgery / instrumentation. Surgery, Computer-Assisted / instrumentation

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  • (PMID = 18415869.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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62. Trisvetova EL: [Clinical diagnostics of papillary fibroelastoma]. Klin Med (Mosk); 2007;85(12):7-11
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  • Papillary fibroelastoma (PFE) is a benign heart tumor, the diagnosis of which is difficult.
  • Clinical manifestations of PFE are non-specific and scarce, and for this reason the tumor is often revealed during a heart surgery of an autopsy.
  • The histogenesis of the tumor is unclear; there are several theories of PFE origin (hemodynamic effects on the myocardium, viral theory, iatrogenic theory etc.
  • ) Macroscopically the tumor is small size, villous, whitish-grey, consists of a pedicle and villi of gely-like soft or dense-elastic consistence.
  • The mobility of the tumor and the fragmentation of its tissue lead to its main complications such as obstruction of cardiac cameras (in-flow and out-flow disorders) and embolic syndrome in various basins (the brain, coronary arteries, the eye, the kidneys, and the lungs).
  • The diagnosis of PFE is made using EchoCG, preferably transesophageal one.
  • Treatment of PFE is surgical and consists of tumor or cusp removal.
  • PFE should be differentiated from other benign and malignant heart tumors, infective endocarditis, heart echinococcosis, coronary artery disease, and cerebrovascular diseases.
  • [MeSH-major] Cardiac Surgical Procedures / methods. Fibroma. Heart Neoplasms. Ventricular Function / physiology
  • [MeSH-minor] Diagnosis, Differential. Echocardiography, Transesophageal. Humans. Papillary Muscles / pathology. Papillary Muscles / ultrasonography. Prognosis

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  • (PMID = 18318158.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 49
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63. Ramlee N, Ramli N, Tajudin LS: Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion. Orbit; 2007 Jun;26(2):137-9
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  • The benign tumor with its intact pseudocapsule was removed through lateral orbitotomy together with the suspicious looking orbital lobe.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Adolescent. Chalazion / diagnosis. Diagnosis, Differential. Female. Humans. Lacrimal Apparatus. Tomography, X-Ray Computed

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  • (PMID = 17613864.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Godeiro KD, Frota AC, Antecka E, Odashiro AN, Maloney S, Fernandes B, Burnier MN Jr: Prostate-specific membrane antigen is undetectable in choroidal neovascular membrane. J Carcinog; 2006;5:21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein expressed in benign and malignant prostatic tissues, in some non-prostatic tissues, and in the endothelium of tumor-associated neovasculature of non-prostatic neoplasm.
  • Some studies have suggested that the expression of PSMA is restricted to endothelium from tumor-associated neovasculature and might be stimulated by some tumor-secreted angiogenic factors.
  • However, no previous study demonstrating PSMA expression in non-related tumor neovasculature, such as CNVM, has been performed to date.
  • CONCLUSION: The absence of PSMA expression in non-tumoral neovasculature supports the theory, previously suggested, that endothelial cell PSMA expression may be stimulated by one or more tumor-secreted angiogenic factors.
  • Angiogenesis is very important in neoplasia and the endothelial expression of PSMA in tumor-associated neovasculature may represent a target for antineovasculature-based therapy.

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  • (PMID = 16911781.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1560378
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65. Orawiec B, Grałek M, Stefańczyk L, Niwald A: Applicability of ultrasound in ocular tumors in children and adolescents. Klin Oczna; 2005;107(7-9):437-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Applicability of ultrasound in ocular tumors in children and adolescents.
  • PURPOSE: Evaluation of the applicability of ultrasound in children diagnosed for neoplasm of the eye.
  • Evaluation of Doppler ultrasound in visualizing blood vessels within the lesion in eye ball, eye socket and eye lids.
  • Establishing the value of the obtained data concerning the image of vessels and blood flow for the diagnosis, monitoring the course of disease and results of treatment.
  • MATERIAL AND METHODS: The study comprised 80 patients diagnosed and treated for neoplasm of the eye.
  • The presence of vessels in tumor mass and blood flow in tumors were useful for differentiation between malignant and benign tumors.
  • The obtained pictures of vessels and flow character are typical for some tumors, which together with histopathology of tumors enables establishing of correct diagnosis.
  • [MeSH-major] Eye Neoplasms / ultrasonography

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  • (PMID = 16416991.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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66. Segal A, Segal N, Gal A, Tumuluri K: Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. Orbit; 2010 Dec;29(6):334-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor.
  • In 12(21.8%) patients a lesion with a benign diagnosis was previously excised from the same location.
  • In 2 of them histological re-examination resulted in a diagnosis of MSA.
  • Recurrence of the tumor was reported in 14(30%) patients.
  • CONCLUSIONS: MSA is a rare tumor of the eyelid with no clinically distinguishing features.
  • The tumor may extend into the orbit and metastasize regionally.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mohs Surgery / methods. Neoplasm Staging. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 21158574.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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67. Evans PM, Lynch GL, Dubielzig RR: Anterior uveal spindle cell tumor in a cat. Vet Ophthalmol; 2010 Nov;13(6):387-90
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  • [Title] Anterior uveal spindle cell tumor in a cat.
  • PURPOSE: To describe a case of anterior uveal spindle cell tumor in a cat with features similar to spindle cell tumor of blue eyed dogs.
  • A diagnosis of a benign epithelial tumor was suggested by a FNA of the mass.
  • CONCLUSIONS: Based on its histopathologic characteristics, this iris tumor was diagnosed as a Schwann cell variant of a peripheral nerve sheath tumor (PNST) closely resembling the spindle cell tumor of blue-eyed dogs.
  • The presence of Antoni type A and type B tissue patterns along with immunohistochemical staining may facilitate a diagnosis of PNST and rule out malignant melanoma.
  • [MeSH-major] Cat Diseases / pathology. Uveal Neoplasms / veterinary

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  • [Copyright] © 2010 American College of Veterinary Ophthalmologists.
  • (PMID = 21182724.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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68. Al Baghli A, Reddy SS, Reddy MA: Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. Middle East Afr J Ophthalmol; 2010 Oct;17(4):374-6

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  • [Title] Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.
  • The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.
  • Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

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  • (PMID = 21180442.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2991459
  • [Keywords] NOTNLM ; Eccrine Glands / Nodular Hidradenoma / Sweat Gland Tumor
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69. Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM: Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol; 2006 Nov;169(5):1767-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
  • Platelet-derived growth factor (PDGF) stimulates tumor growth and progression by affecting tumor and stromal cells.
  • In the HaCaT skin carcinogenesis model, transfection of immortal nontumorigenic and PDGF-receptor-negative HaCaT keratinocytes with PDGF-B induced formation of benign tumors.
  • In vivo, persistent PDGF-B expression induced enhanced tumor cell proliferation but only transiently stimulated stromal cell proliferation and angiogenesis.
  • The PDGF-induced, persistently increased expression of the hepatocyte growth factor by fibroblasts in vitro and in vivo was most probably responsible for enhanced epithelial cell proliferation and benign tumor formation.
  • Thus, by paracrine stimulation of the stroma, PDGF-BB induced epithelial hyperproliferation, thereby promoting tumorigenicity, whereas the time-limited activation of the stroma followed by stromal maturation provides a possible explanation for the benign tumor phenotype.
  • [MeSH-major] Epithelial Cells / drug effects. Epithelial Cells / pathology. Growth Substances / pharmacology. Neoplasms / pathology. Phenotype. Platelet-Derived Growth Factor / pharmacology. Stromal Cells / drug effects

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  • (PMID = 17071599.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Endostatins; 0 / Growth Substances; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 0 / platelet-derived growth factor BB; 67256-21-7 / Hepatocyte Growth Factor; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
  • [Other-IDs] NLM/ PMC1780216
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70. Hajji Z, Charif Chefchaouni M, Chaoui Z, Agnaou L, Berraho A: [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report]. J Fr Ophtalmol; 2005 Jun;28(6):614-7
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  • [Title] [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report].
  • [Transliterated title] Difficultés diagnostiques face à une tumeur papillaire pigmentée. A propos d'un cas.
  • Melanocytoma of the optic disc is a benign pigmented tumor located on the optic nerve head.
  • We present a case of melanocytoma in a 49-year-old woman who presented with decreased vision in her left eye.
  • The tumor was stationary for 20 months.
  • Unusual features of melanocytoma (superior nasal location in the optic disc with an adjacent choroidal component, a decrease in visual acuity and disc edema surrounding the tumor) are discussed.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Eye Neoplasms / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Optic Nerve Neoplasms / diagnosis. Pigmentation Disorders / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Fluorescein Angiography. Humans. Melanocytes / pathology. Middle Aged

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  • (PMID = 16141925.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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71. Kiss S, Gragoudas ES, Dryja TP, Jakobiec FA: Response of choroidal leiomyoma to treatment with proton beam radiation. Retin Cases Brief Rep; 2010;4(2):168-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Uveal leiomyoma is a rare, benign smooth muscle neoplasm usually diagnosed only after local resection or enucleation.
  • CASE REPORT: A 51-year-old woman presented with a choroidal mass in the left eye that was initially diagnosed as a choroidal melanoma.
  • The neoplasm was treated with a total of 70 cobalt gray equivalents of external proton beam radiation in 5 fractions over 7 days.
  • Biannual follow-up examinations over 3 years showed a funduscopically and ultrasonographically regressing tumor.
  • The left eye was enucleated approximately 3 years postradiotherapy because of progressively increasing pain secondary to elevated intraocular pressure from neovascular glaucoma.
  • Microscopic and immunohistochemical examination of the mass revealed a choroidal neoplasm expressing smooth muscle antigens consistent with a uveal leiomyoma.

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  • (PMID = 25390394.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Rizvi SA, Gupta Y, Gupta M: Surgical treatment and histopathological analysis of proptosis. Nepal J Ophthalmol; 2010 Jan-Jun;2(1):31-4
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  • According to location and type of tumour, different surgical options like anterior orbitotomy, lateral orbitotomy and medial orbitotomy were considered.
  • The most common benign adult tumor found in our study was pleomorphic adenoma of the lacrimal gland {3 (20%)}.
  • Early diagnosis and timely surgical intervention provide good functional and cosmetic results.
  • [MeSH-major] Exophthalmos / surgery. Eye Neoplasms / pathology. Ophthalmologic Surgical Procedures / methods. Orbital Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 21141324.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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73. Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA: [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol; 2006 Apr;81(4):217-9
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  • [Transliterated title] Queratosis seborreica de la conjuntiva: informe de un caso.
  • A 37-year-old man presented with a pigmented mass involving the conjunctiva of his right eye.
  • Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed.
  • The histopathologic diagnosis was seborrheic keratosis.
  • DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival pigmented lesions.

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  • (PMID = 16688646.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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74. Ohnishi Y, Saika S, Yamanaka O, Okada Y, Shirai K, Miyamoto T, Nishikawa I, Tanaka T, Miyazaki K: [Investigation of mechanism of cell proliferation regulation and its clinical application]. Nippon Ganka Gakkai Zasshi; 2005 Dec;109(12):865-83; discussion 884

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  • Cell proliferation and related cellular behavior in ocular neoplastic disease and in the healing process in ocular surgery or post-injury management, as well as new treatment strategy were investigated.
  • Cell proliferation-related signals were found to be activated to a greater extent in malignant ocular tumors than in benign tumor cells regardless of the similarity of simple histological findings.
  • Suppression of cell proliferation-related signals can be a new treatment for ocular neoplastic diseases.
  • [MeSH-minor] Animals. Eye Neoplasms / pathology. Eye Neoplasms / therapy. Gene Expression Regulation, Developmental. Genetic Therapy. Hedgehog Proteins. Humans. Ocular Physiological Phenomena. Trans-Activators / physiology. Wound Healing / genetics. Wound Healing / physiology

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  • (PMID = 16408488.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Smad Proteins; 0 / Trans-Activators; 0 / Transcription Factor AP-1; 0 / Transforming Growth Factor beta
  • [Number-of-references] 77
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75. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7

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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.
  • Subretinal hemorrhage in the left eye from polypoidal neovascularization in the macula was successfully treated with photodynamic therapy.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Sidani CA, Karam AR, Bruce JH, Sklar E: Osteoblastoma of the frontal sinuses presenting with headache and blurred vision: case report and review of the literature. J Radiol Case Rep; 2010;4(6):1-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is a rare benign bone tumor that usually arises in the vertebral column and long bones of young adults.
  • We report an osteoblastoma of both frontal sinuses in a 23-year-old male who presented with headache and blurry vision in the left eye.

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  • (PMID = 22470734.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303412
  • [Keywords] NOTNLM ; Frontal sinus / exophthalmos / osteoblastoma
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77. Roberts DS, Faquin WC, Deschler DG: Giant cell tumors of the temporal bone and infratemporal fossa: a case report and review of the literature. Laryngoscope; 2010;120 Suppl 4:S180
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  • OBJECTIVES: To report a giant cell tumor (GCT) of temporal bone and infratemporal fossa and to review the literature pertinent to the care of such patients.
  • RESULTS: Six case reports over 23 years illustrate that these benign locally destructive lesions may originate in the temporal bone with extension into the infratemporal fossa.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Temporal Bone / pathology

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  • (PMID = 21225778.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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78. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G: How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol; 2010 Sep;63(3):361-74; quiz 375-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors.
  • Dermoscopy is a noninvasive tool that can be helpful in the diagnosis of nonpigmented skin tumors.
  • This is because dermoscopy permits the visualization of key vascular structures that are usually not visible to the naked eye.
  • Much work has concentrated on the identification of specific morphologic types of vessels that allow a classification into melanocytic versus nonmelanocytic and benign versus malignant nonpigmented skin tumors.
  • Aside from vascular morphology, the architectural arrangement of vessels within the tumor and the presence of additional dermoscopic clues are equally important for the diagnosis.
  • Part I discusses the dermoscopic vascular patterns of benign and malignant melanocytic skin tumors.
  • Part II discusses the dermoscopic vascular patterns of benign and malignant nonmelanocytic nonpigmented skin tumors.
  • In each part, additional special management guidelines for melanocytic and nonmelanocytic nonpigmented skin tumors, respectively, will be discussed.
  • [MeSH-major] Blood Vessels / pathology. Dermoscopy / methods. Melanocytes / pathology. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Male. Melanoma / blood supply. Melanoma / diagnosis. Melanoma / pathology. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology. Regional Blood Flow. Skin / blood supply

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  • [Copyright] Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20708469.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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79. Kernt M, Schaller UC, Stumpf C, Ulbig MW, Kampik A, Neubauer AS: Choroidal pigmented lesions imaged by ultra-wide-field scanning laser ophthalmoscopy with two laser wavelengths (Optomap). Clin Ophthalmol; 2010;4:829-36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Choroidal melanoma is the most prevalent primary neoplasia among malignant ocular tumors, and metastasis often occurs before the primary tumor is diagnosed.
  • We investigated the imaging properties of clinically diagnosed melanocytic choroidal tumors using a nonmydriatic ultra-wide-field scanning laser ophthalmoscope (SLO) with two laser wavelengths to distinguish benign from malignant lesions.
  • METHODS: In a consecutive series of 49 patients with clinically diagnosed melanocytic choroidal tumors in one eye, 29 had established melanoma (defined by proven growth on repeated US follow-up) and 20 had nevi (defined by no malignancy according to clinical, US, and growth characteristics for at least 2 years).
  • Measurements of the tumor base using the Optomap software were compared with US B-scan measurements.
  • RESULTS: Measurements of tumor base correlated well between SLO and US with r = 0.61 (T-direction) and r = 0.51 (L-direction).
  • CONCLUSIONS: In this first, limited series, nonmydriatic SLO imaging with two laser wavelengths permitted to differentiate malignant ocular tumors from nonmalignant lesions with high diagnostic accuracy.

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  • (PMID = 20689737.001).
  • [ISSN] 1177-5483
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2915871
  • [Keywords] NOTNLM ; choroidal melanoma / imaging / nevus / ultra-wide-field scanning laser ophthalmoscopy
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80. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Facial Paralysis / etiology. Parotid Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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81. Jakobiec FA, Nguyen J, Bhat P, Fay A: Recurrent blue nevus of the corneoscleral limbus. Cornea; 2010 Aug;29(8):947-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Ki-67 proliferation index was very low (0.05%), supporting a benign diagnosis.
  • CONCLUSIONS: Careful histopathological and immunohistochemical evaluation of recurrent, incompletely excised, blue nevi can determine if they remain benign.
  • [MeSH-major] Corneal Diseases / surgery. Eye Neoplasms / surgery. Neoplasm Recurrence, Local. Nevus, Blue / surgery. Scleral Diseases / surgery
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Cryotherapy. Female. Humans. Sclerostomy

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  • (PMID = 20508501.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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82. Rodríguez-Piñeiro AM, Blanco-Prieto S, Sánchez-Otero N, Rodríguez-Berrocal FJ, de la Cadena MP: On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. J Proteomics; 2010 Jun 16;73(8):1511-22
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  • [Title] On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion.
  • The current imperative need for new biomarkers of non-small cell lung cancer (NSCLC) prompted us to compare the proteome of serum and pleural effusion samples from cancer patients with those with benign lung diseases as pneumonia or tuberculosis.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / chemistry. Lung Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Electrophoresis, Gel, Two-Dimensional. Eye Proteins / analysis. Female. Humans. Male. Middle Aged. Nerve Growth Factors / analysis. Pleural Effusion / metabolism. Pleural Effusion, Malignant / metabolism. Pneumonia / metabolism. Protein Isoforms / analysis. Proteomics / methods. Serpins / analysis. Tuberculosis, Pulmonary / metabolism

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20230924.001).
  • [ISSN] 1876-7737
  • [Journal-full-title] Journal of proteomics
  • [ISO-abbreviation] J Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / Protein Isoforms; 0 / Serpins; 0 / pigment epithelium-derived factor
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83. Abouzeid H, Schorderet DF, Balmer A, Munier FL: Germline mutations in retinoma patients: relevance to low-penetrance and low-expressivity molecular basis. Mol Vis; 2009;15:771-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To study phenotype-genotype correlation in patients who have retinoma, which is a benign tumor resembling the post irradiation regression pattern of retinoblastoma (RB).
  • METHODS: We selected patients who had retinoma and positive family history for RB and patients who had retinoma in one eye and either retinoma or RB in the other eye.
  • There was no correlation between the type of mutation and the number of tumor foci per eye (RB or retinomas).
  • [MeSH-major] Germ-Line Mutation. Retinal Neoplasms / genetics. Retinoblastoma / genetics. Retinoblastoma Protein / genetics

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  • (PMID = 19390654.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
  • [Other-IDs] NLM/ PMC2671583
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84. Archondakis S, Skagias L, Tsakiris A, Sambaziotis D, Daskalopoulou D: Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology. Diagn Cytopathol; 2009 Jun;37(6):443-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Oncocytomas are benign tumors that infrequently involve ocular adnexa.
  • An 83-year-old patient presented to the cytology laboratory with a peripunctal mass in the right eye.
  • The tumor was aspirated.
  • The cytoplasm of the tumor cells was rich in eosinophilic granules.
  • The initial cytological diagnosis was oncocytoma.
  • The tumor was then completely excised and the histological diagnosis confirmed the initial cytological one.
  • Oncocytoma is a rare entity which must be considered in differential diagnosis of a peripunctal mass in elderly patients.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Lacrimal Apparatus / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217061.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Müller CS, Tilgen W, Kutzner H, Pföhler C: Recurring mixed-type neurothekeoma of the face. Dermatoendocrinol; 2009 Jul;1(4):220-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Neurothekeomas are rare, benign neoplasms, typically occurring in younger patients with a remarkable predilection for the female population.
  • The rarity of this unusual skin tumor in daily routine histopathologic findings prompted the following report.
  • OBSERVATION: We report a 17-year-old girl with an asymptomatic nodule at the inner angle of the left eye with slow progression in size within 12 months to 1 cm in diameter.
  • Multiple treatments with laser surgery were performed and yielded no persistent remission of the tumor.
  • Histopathologic examination revealed a non-encapsulated dermal tumor, composed of multiple, closely situated medium-sized nodules, separated by a myxoid collagenrich stroma, without epidermal alteration.
  • In summary, due to the histoarchitecture and immunoprofile of the tumor, a mixed-type cellular neurothekeoma was diagnosed.

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  • [Cites] Histopathology. 1998 May;32(5):414-22 [9639116.001]
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  • (PMID = 20592794.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835878
  • [Keywords] NOTNLM ; cellular / nerve sheath tumor / neurothekeoma / skin / soft tissue tumor
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86. Bodack MI: Ptosis and cranial nerve IV palsy reveal juvenile myasthenia gravis. Optometry; 2009 Jul;80(7):342-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In both cases, these conditions can be benign and require no further workup.
  • If a patient presents with multiple neurologic signs, a sudden onset eye turn, or ptosis, the patient must undergo a workup to rule out a pathologic etiology, specifically a brain tumor.
  • If the results of the neuroimaging are normal, and the findings are variable, myasthenia gravis should be considered, and additional testing should be ordered to assist in the diagnosis.
  • Diagnosis of myasthenia gravis was made based on clinical presentation and response to ice pack testing.
  • CONCLUSIONS: Although rare, myasthenia should be considered a diagnosis in children who present with variable ptosis or strabismus.
  • [MeSH-major] Blepharoptosis / etiology. Myasthenia Gravis / complications. Myasthenia Gravis / diagnosis. Strabismus / etiology. Trochlear Nerve Diseases / etiology
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Neurology. Optometry. Referral and Consultation

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  • [ErratumIn] Optometry. 2009 Sep;80(9):466
  • (PMID = 19545846.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Frei-Jones M, McKinstry RC, Perry A, Leonard JR, Park TS, Rubin JB: Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. J Neurosurg Pediatr; 2008 Aug;2(2):125-9
Hazardous Substances Data Bank. THALIDOMIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Infantile or capillary hemangioma is the most common vascular tumor of childhood.
  • Although the lesions are considered benign, 10% of affected children develop life-threatening complications (mortality rate 20-80% in this subgroup).
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Brain Neoplasms / congenital. Brain Neoplasms / drug therapy. Hemangioma, Capillary / congenital. Hemangioma, Capillary / drug therapy. Thalidomide / therapeutic use

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  • (PMID = 18671617.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K30 RR022251; United States / NCRR NIH HHS / RR / TL1 RR024995; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992-01; United States / NCATS NIH HHS / TR / UL1 TR000448
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
  • [Other-IDs] NLM/ NIHMS101679; NLM/ PMC2737696
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88. Cohen VM, Shields CL, Furuta M, Shields JA: Vitreous seeding from retinal astrocytoma in three cases. Retina; 2008 Jun;28(6):884-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: An asymptomatic 8-year-old boy (Case 1) presented with a white juxtapapillary retinal tumor and extensive overlying large vitreous seeds.
  • Fine-needle aspiration biopsy (FNAB) confirmed the diagnosis of benign retinal astrocytoma.
  • A 5-year-old boy (Case 2) presented with a large, multilobulated, tan juxtapapillary retinal tumor.
  • Histopathologic analysis of the enucleated globe supported the diagnosis of retinal astrocytoma.
  • The tumor height increased from 2.5 mm to 5.5 mm, and total retinal detachment developed.
  • After enucleation, the diagnosis of retinal astrocytoma was confirmed.
  • CONCLUSIONS: Retinal astrocytoma can produce vitreous seeds, sometimes associated with tumor growth.
  • Care should be taken to exclude the diagnosis of retinoblastoma.
  • [MeSH-major] Astrocytoma / secondary. Eye Neoplasms / secondary. Neoplasm Seeding. Retinal Neoplasms / pathology. Vitreous Body / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Eye Enucleation. Female. Humans. Male. Retrospective Studies

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  • (PMID = 18536607.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Canovas D, Rennie IG, Nichols CE, Sisley K: Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory. Cancer; 2008 Apr 15;112(8):1787-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor location, and the baseline invasion of the melanoma, affected the ability of aqueous and vitreous from different patients to regulate invasive behavior.
  • CONCLUSIONS: The findings suggest that in situ uveal melanoma development reflects an interaction between the tumor and the environment of the eye.
  • Exposure to the aqueous would therefore contribute to the benign nature of iris melanomas, whereas potential interaction with the vitreous appears to promote the aggressive behavior of posterior uveal melanomas.
  • [MeSH-major] Aqueous Humor / physiology. Melanoma / pathology. Uveal Neoplasms / pathology. Vitreous Body / physiopathology
  • [MeSH-minor] Adult. Aged. Anticarcinogenic Agents / pharmacology. Carcinogens / pharmacology. Cell Line, Tumor. Cell Proliferation. Chemotaxis / physiology. Choroid Neoplasms / pathology. Ciliary Body / pathology. Cytokines / drug effects. Female. Follow-Up Studies. Humans. Iris Neoplasms / pathology. Male. Middle Aged. Neoplasm Invasiveness. Tissue Culture Techniques. Tissue Inhibitor of Metalloproteinase-2 / drug effects. Tissue Inhibitor of Metalloproteinase-3 / drug effects. Transforming Growth Factor beta2 / drug effects

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  • (PMID = 18300240.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Cytokines; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transforming Growth Factor beta2; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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90. Connolly G, Wladis E, Masselam K, Weinberg DA: Contralateral orbital melanoma 28 years following enucleation for choroidal melanoma. Orbit; 2007 Dec;26(4):291-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He underwent radiotherapy of the residual tumor at the left orbital apex, as well as radiotherapy of small liver and lung nodules felt to likely represent metastatic melanoma.
  • Five years later, he was still alive and well, with no further tumor demonstrable in the orbit, lung or liver.
  • We discuss some hypotheses that may explain such tumor behavior.
  • While melanoma is often considered a highly malignant and lethal tumor, some melanomas are characterized by a more benign course.
  • [MeSH-major] Choroid Neoplasms / pathology. Melanoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Aged. Exophthalmos. Eye Enucleation. Humans. Male. Tomography, X-Ray Computed. Visual Acuity

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  • (PMID = 18097971.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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91. Tran HV, Bovey EH, Uffer S, Zografos L: Peripapillary choroidal neovascularization associated with melanocytoma of the optic disc: a clinicopathologic case report. Graefes Arch Clin Exp Ophthalmol; 2006 Oct;244(10):1367-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Melanocytoma of the optic disc is a benign melanocytic tumor that rarely causes visual impairment.
  • METHODS: A 45-year-old southern European patient had a melanocytoma of the optic disc in his left eye with vision of 20/100.
  • [MeSH-major] Choroidal Neovascularization / pathology. Nevus, Pigmented / pathology. Optic Disk / pathology. Optic Nerve Neoplasms / pathology

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  • (PMID = 16523299.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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92. Perez DE, Pires FR, Almeida OP, Kowalski LP: Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases. Otolaryngol Head Neck Surg; 2006 Feb;134(2):321-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors.
  • Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 16455384.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Al-Khiary H, Ayoubi A, Elkhamary SM: Primary orbital ganglioneuroma in a 2-year-old healthy boy. Saudi J Ophthalmol; 2010 Jul;24(3):101-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He underwent orbital exploration via anterior orbitotomy incision and debulking of the tumor was done.
  • The histopathological examination confirmed the diagnosis of orbital ganglioneuroma.
  • Ganglioneuroma is an unusual benign tumor of neuroplastic origin with extremely rare orbital involvement with only one prior reported case in a youth.
  • The tumor is slow growing and non-metastasizing.

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  • (PMID = 23960884.001).
  • [ISSN] 1319-4534
  • [Journal-full-title] Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
  • [ISO-abbreviation] Saudi J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3729488
  • [Keywords] NOTNLM ; Ganglioneuroma / Neuroblastoma / Pediatric / Unilateral proptosis
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94. Bianciotto C, Shields CL, Lally SE, Freire J, Shields JA: CyberKnife radiosurgery for the treatment of intraocular and periocular lymphoma. Arch Ophthalmol; 2010 Dec;128(12):1561-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lymphoma type was classified as extranodal marginal zone B-cell lymphoma in 7 eyes (50%), diffuse large B-cell lymphoma in 3 eyes (21%), follicular lymphoma in 2 eyes (14%), and benign reactive lymphoid hyperplasia in 2 eyes (14%).
  • Complete tumor resolution without local recurrence over a mean follow-up of 23 months was documented in all cases.
  • Radiation-associated adverse effects included mild dry eye in 2 patients and cataract in 1 patient with conjunctival lymphoma.
  • There was no radiation retinopathy or papillopathy, and visual acuity was preserved or improved in 13 eyes and decreased in 1 eye due to the presence of cataract.
  • [MeSH-major] Eye Neoplasms / surgery. Lymphoma, Non-Hodgkin / surgery. Pseudolymphoma / surgery. Radiosurgery

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  • (PMID = 21149780.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Jakobiec FA, Bhat P, Colby KA: Immunohistochemical studies of conjunctival nevi and melanomas. Arch Ophthalmol; 2010 Feb;128(2):174-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations.
  • CONCLUSIONS: S-100 and MART-1 were not useful in separating benign from malignant lesions.
  • Immunostaining for HMB-45 and Ki-67 are valuable adjuncts to careful histopathologic evaluation in assessing benign and malignant conjunctival melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD45 / analysis. Antigens, Neoplasm / analysis. Child. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • (PMID = 20142539.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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96. Koletsa T, Karayannopoulou G, Dereklis D, Vasileiadis I, Papadimitriou CS, Hytiroglou P: Mesectodermal leiomyoma of the ciliary body: report of a case and review of the literature. Pathol Res Pract; 2009;205(2):125-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesectodermal leiomyoma of the ciliary body is a rare benign tumor with double (muscular and neural) differentiation.
  • This neoplasm is considered to originate from the ciliary body smooth muscle, a neural crest derivative.
  • We report a case of mesectodermal leiomyoma of the right eye occurring in a 53-year-old woman, who presented with significant decrease of visual acuity.
  • The tumor measured 1.2cm in greatest dimension, and consisted of spindle and ovoid cells with abundant fibrillary cytoplasmic processes.
  • A review of the 23 cases thus far reported in the literature shows a striking predilection for women, as well as significant difficulties in differentiating this tumor from malignant melanoma on clinical grounds.
  • [MeSH-major] Ciliary Body / pathology. Leiomyoma / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18930601.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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97. Lessell S, Kim JW, Hatton MP, Stemmer-Rachamimov A, Thiagalingham S, Rubin PA: Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. J Neuroophthalmol; 2007 Jun;27(2):104-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 28-year-old man with a biopsy-proven benign intraorbital optic nerve sheath meningioma developed recurrent clinical manifestations of ipsilateral retrobulbar inflammation 9 years after undergoing postoperative radiation therapy.
  • Debulking of the tumor 11 years after the original surgery again revealed no pathologic signs of inflammation.
  • Whether growth of tumor, surgery, radiation, or edema triggered the inflammatory manifestations is unclear.
  • [MeSH-major] Inflammation / complications. Meningeal Neoplasms / complications. Meningioma / complications. Optic Nerve Neoplasms / complications

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  • (PMID = 17548993.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Kim HJ, Shields CL, Eagle RC Jr, Shields JA: Fibrous histiocytoma of the conjunctiva. Am J Ophthalmol; 2006 Dec;142(6):1036-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor was present for a mean of three months (median, five months; range, one to 12 months) and was unilateral (one right eye, five left eyes).
  • In all cases, the tumor was a tan, dome-shaped limbal mass in the conjunctival stroma with visible intrinsic vessels.
  • The mean tumor basal dimension was 7 mm (median, 5 mm; range, 4 to 11 mm).
  • Surgical resection was performed in all cases, and histopathologic study demonstrated benign FH in four cases and malignant FH in two cases.
  • Those cases with benign FH showed no recurrence over nine months (median, eight months; range, three to 18 months).
  • CONCLUSION: FH is a rare conjunctival tumor that can show benign or malignant features.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17157587.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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99. Farmer JP, Lamba M, McDonald H, Commons AS: Orbital giant cell angiofibroma: immuno-histochemistry and differential diagnosis. Can J Ophthalmol; 2006 Apr;41(2):216-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital giant cell angiofibroma: immuno-histochemistry and differential diagnosis.
  • COMMENTS: Giant cell angiofibroma is a benign spindle cell neoplasm characterized by multinucleated giant cells and pseudovascular spaces with a propensity to occur in the anterior soft tissues of the orbit of middle-aged adults.
  • It is part of a wide differential diagnosis of tumours that can be separated by various histologic and immunohistochemical features, which are discussed in the report.
  • It is important to consider it preoperatively because the vascular nature of this tumour may create problems with hemostasis during excision.

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  • (PMID = 16767212.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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100. Kim BH, Henderson BA: Intraocular choristoma. Semin Ophthalmol; 2005 Oct-Dec;20(4):223-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although it is regarded as a benign tumor, it grows progressively and can decrease visual function.
  • [MeSH-major] Choristoma / diagnosis. Eye Diseases / diagnosis
  • [MeSH-minor] Animals. Diagnosis, Differential. Humans

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  • (PMID = 16352493.001).
  • [ISSN] 0882-0538
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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