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Items 1 to 74 of about 74
1. Ethmoidal osteoid osteoma with orbital and intracranial extension - a case report. BMC Ear Nose Throat Disord; 2005 Mar 11;5:2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones of appendicular skeleton.
  • He presented with loss of vision in the left eye.
  • Radical excision of the tumor could thus be achieved through a craniofacial approach.
  • CONCLUSION: Although benign and rare, skull base osteoid osteoma can present with neurological deficit due to its mass effect and involvement of vital structures.

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  • (PMID = 15760476.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC555567
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2. Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR: Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol; 2008 Mar 24;180(6):1277-89
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1.
  • Tumor cells undergo epithelial-to-mesenchymal transition (EMT) to convert from a benign to a malignant phenotype.
  • We have shown that human pancreatic cancer cells respond to collagen by up-regulating N-cadherin, which promotes tumor growth, invasion, and metastasis.
  • Initial characterization showed that knocking down c-Jun NH2-terminal kinase prevented N-cadherin up-regulation and limited tumor growth and invasion in a mouse model for pancreatic cancer.

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  • (PMID = 18362184.001).
  • [ISSN] 1540-8140
  • [Journal-full-title] The Journal of cell biology
  • [ISO-abbreviation] J. Cell Biol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01-GM51188; United States / NIDCR NIH HHS / DE / R01-DE12308; United States / NIDCR NIH HHS / DE / R01 DE012308; United States / NCI NIH HHS / CA / P30 CA036727; United States / NCI NIH HHS / CA / P30 CA36727; United States / NIGMS NIH HHS / GM / R01 GM051188
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCAR1 protein, human; 0 / Cadherins; 0 / Collagen Type I; 0 / Crk-Associated Substrate Protein; 0 / Integrin alpha2beta1; 0 / Receptors, Mitogen; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / discoidin receptor; EC 2.7.10.2 / Focal Adhesion Kinase 2; EC 2.7.10.2 / Focal Adhesion Protein-Tyrosine Kinases; EC 3.6.5.2 / rap1 GTP-Binding Proteins
  • [Other-IDs] NLM/ PMC2290851
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3. Karl A, Stepp H, Willmann E, Buchner A, Hocaoglu Y, Stief C, Tritschler S: Optical coherence tomography for bladder cancer -- ready as a surrogate for optical biopsy? Results of a prospective mono-centre study. Eur J Med Res; 2010 Mar 30;15(3):131-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: New modalities like Optical Coherence Tomography (OCT) allow non-invasive examination of the internal structure of biological tissue in vivo.
  • Of all analyzed lesions 88 were benign (inflammation, edema, hyperplasia etc.) and 14 were malignant (CIS, Ta, T1, T2) as shown by final histo?pathology.
  • Furthermore all invasive tumors were staged correctly by OCT regarding tumor growth beyond the lamina propria.
  • Sensitivity of OCT for detecting the presence of a malignant lesion was 100% and sensitivity for detection of tumor growth beyond the lamina propria was 100% as well.
  • CONCLUSION: As a minimally invasive technique, OCT proved to have extremely high sensitivity for detection of malignant lesions as well as estimation of whether a tumor has invaded beyond the lamina propria.
  • [MeSH-major] Cystoscopy. Tomography, Optical Coherence. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Prospective Studies. Sensitivity and Specificity. Young Adult

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  • (PMID = 20452899.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3352220
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4. Godeiro KD, Frota AC, Antecka E, Odashiro AN, Maloney S, Fernandes B, Burnier MN Jr: Prostate-specific membrane antigen is undetectable in choroidal neovascular membrane. J Carcinog; 2006;5:21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein expressed in benign and malignant prostatic tissues, in some non-prostatic tissues, and in the endothelium of tumor-associated neovasculature of non-prostatic neoplasm.
  • Some studies have suggested that the expression of PSMA is restricted to endothelium from tumor-associated neovasculature and might be stimulated by some tumor-secreted angiogenic factors.
  • However, no previous study demonstrating PSMA expression in non-related tumor neovasculature, such as CNVM, has been performed to date.
  • CONCLUSION: The absence of PSMA expression in non-tumoral neovasculature supports the theory, previously suggested, that endothelial cell PSMA expression may be stimulated by one or more tumor-secreted angiogenic factors.
  • Angiogenesis is very important in neoplasia and the endothelial expression of PSMA in tumor-associated neovasculature may represent a target for antineovasculature-based therapy.

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  • (PMID = 16911781.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1560378
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5. Mahoney NR, Liu GT: Benign recurrent sixth (abducens) nerve palsies in children. Arch Dis Child; 2009 May;94(5):394-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign recurrent sixth (abducens) nerve palsies in children.
  • Sixth nerve palsy can occur as a result of elevated intracranial pressure, neoplasm or trauma.
  • Reports from tertiary centres indicate that between 5% and 16% of referred cases have no ascribed aetiology and are classified as benign.
  • Rarely, these benign palsies can recur.
  • A retrospective chart review of a cohort of 253 paediatric patients with sixth nerve palsies was analysed and uncovered 30 cases of benign sixth nerve palsy, nine of which recurred.
  • Our data and review of other studies on the subject imply that a new onset sixth nerve palsy presenting in children can be benign in approximately 13% of cases, so a thorough history and physical examination to evaluate for any other neurological symptoms or signs followed by MRI of the brain with and without contrast is recommended.

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  • (PMID = 19131423.001).
  • [ISSN] 1468-2044
  • [Journal-full-title] Archives of disease in childhood
  • [ISO-abbreviation] Arch. Dis. Child.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Zhou M, Xu G, Bojanowski CM, Song Y, Chen R, Sun X, Wang W, Chan CC: Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma. Acta Ophthalmol Scand; 2006 Feb;84(1):137-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma.
  • PURPOSE: To describe a case with motile cyst in the anterior chamber in the right eye of a 7-year-old boy.
  • METHODS: The right eye's visual acuity was 20/50.
  • Medulloepithelioma with malignant criteria was diagnosed and the eye was enucleated.
  • CONCLUSION: Intraocular medulloepithelioma is a rare embryonic benign or malignant neoplasm typically diagnosed in the first decade of life as a ciliary body mass.

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  • (PMID = 16445454.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z01 EY000222-22
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Other-IDs] NLM/ NIHMS54981; NLM/ PMC2441603
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7. Canovas D, Rennie IG, Nichols CE, Sisley K: Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory. Cancer; 2008 Apr 15;112(8):1787-94
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  • Tumor location, and the baseline invasion of the melanoma, affected the ability of aqueous and vitreous from different patients to regulate invasive behavior.
  • CONCLUSIONS: The findings suggest that in situ uveal melanoma development reflects an interaction between the tumor and the environment of the eye.
  • Exposure to the aqueous would therefore contribute to the benign nature of iris melanomas, whereas potential interaction with the vitreous appears to promote the aggressive behavior of posterior uveal melanomas.
  • [MeSH-major] Aqueous Humor / physiology. Melanoma / pathology. Uveal Neoplasms / pathology. Vitreous Body / physiopathology
  • [MeSH-minor] Adult. Aged. Anticarcinogenic Agents / pharmacology. Carcinogens / pharmacology. Cell Line, Tumor. Cell Proliferation. Chemotaxis / physiology. Choroid Neoplasms / pathology. Ciliary Body / pathology. Cytokines / drug effects. Female. Follow-Up Studies. Humans. Iris Neoplasms / pathology. Male. Middle Aged. Neoplasm Invasiveness. Tissue Culture Techniques. Tissue Inhibitor of Metalloproteinase-2 / drug effects. Tissue Inhibitor of Metalloproteinase-3 / drug effects. Transforming Growth Factor beta2 / drug effects

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  • (PMID = 18300240.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Cytokines; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transforming Growth Factor beta2; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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8. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • In conclusion, we demonstrate downregulation of alphaB-crystallin expression in highly dedifferentiated ATCs because of a tumor-specific transcription factor pattern.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Regulation, Neoplastic. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics. Protein Kinases / genetics. Repressor Proteins / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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9. Kiss S, Gragoudas ES, Dryja TP, Jakobiec FA: Response of choroidal leiomyoma to treatment with proton beam radiation. Retin Cases Brief Rep; 2010;4(2):168-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Uveal leiomyoma is a rare, benign smooth muscle neoplasm usually diagnosed only after local resection or enucleation.
  • CASE REPORT: A 51-year-old woman presented with a choroidal mass in the left eye that was initially diagnosed as a choroidal melanoma.
  • The neoplasm was treated with a total of 70 cobalt gray equivalents of external proton beam radiation in 5 fractions over 7 days.
  • Biannual follow-up examinations over 3 years showed a funduscopically and ultrasonographically regressing tumor.
  • The left eye was enucleated approximately 3 years postradiotherapy because of progressively increasing pain secondary to elevated intraocular pressure from neovascular glaucoma.
  • Microscopic and immunohistochemical examination of the mass revealed a choroidal neoplasm expressing smooth muscle antigens consistent with a uveal leiomyoma.

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  • (PMID = 25390394.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Deng A, Petrali J, Jaffe D, Sina B, Gaspari A: Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol; 2005 Oct;27(5):432-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign cutaneous pseudoglandular schwannoma: a case report.
  • Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion.
  • There are also a few reported cases in the literature of pseudoglandular schwannoma from central nervous system, eye, submandible, and shoulder, in which the gland-like structures were lined by Schwann cells.
  • We report here a patient with a benign cutaneous schwannoma composed of predominantly gland-like spaces that contained mucinous material and were lined by Schwann cells confirmed by immunohistochemistry and ultrastructural studies.
  • The tumor was well circumscribed and showed minimal cytologic atypia, indicating benignity.
  • We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphologic diversity of schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16148415.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Jack LS, Smith TL, Ng JD: Frontal sinus osteoma presenting with orbital emphysema. Ophthal Plast Reconstr Surg; 2009 Mar-Apr;25(2):155-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoma is the most common neoplasm of the paranasal sinuses usually involving the frontal sinus.
  • Osteomas are benign, but can cause serious intracranial or orbital complications.
  • The authors report a frontal sinus osteoma with orbital emphysema in a 16-year-old boy with a history of right-eye swelling after nose blowing.
  • [MeSH-major] Emphysema / etiology. Frontal Sinus. Orbital Diseases / etiology. Osteoma / complications. Paranasal Sinus Neoplasms / complications

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  • (PMID = 19300171.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Galanov AV, Konovalov AN, Kornienko VN, Il'ialov SR, Kostiuchenko VV, Pronin IN, Mariashev SA, Iakovlev SB, Lubnin AIu, Serova NK, Nikonova NG: [First experience with a Gamma-knife unit used for radiosurgical treatment for intracranial space-occupying lesions]. Zh Vopr Neirokhir Im N N Burdenko; 2007 Jan-Mar;(1):3-10
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  • Three hundred and six patients with various intracranial diseases (137 with malignant tumors, 136 with benign tumors, and 33 patients with vascular diseases) underwent radiosurgery on a Gamma-Knife unit for over 1.5 years, from May 2005 to October 2006.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain Neoplasms / pathology. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Child. Child, Preschool. Equipment Design. Eye Diseases / surgery. Female. Humans. Male. Meningioma / radiotherapy. Meningioma / surgery. Middle Aged. Neoplasm Metastasis. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

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  • (PMID = 17526246.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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13. Li Y, Zhang TM, An YZ, Shi JT, Fu JD, Qiu E: [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae]. Zhonghua Yi Xue Za Zhi; 2006 Jun 20;86(23):1597-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae].
  • OBJECTIVE: To investigate the clinical manifestations of lacrimal gland tumor involving the anterior and middle cranial fossae and the effect of transcranial-orbital approach in treatment of such tumor.
  • METHODS: A retrospective study was conducted on the clinical data of 23 cases lacrimal gland tumor involving the anterior and middle cranial fossae confirmed by radiological examination, including 11 cases of adenoid cystic carcinoma, 6 cases of pleomorphic adenocarcinoma (malignant mixed tumor), 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma, 1 case of ductal carcinoma, 1 case of mucoepidermoid carcinoma, and 1 case of benign mixed tumor, 15 males and 8 females, aged 42.5 (2 - 76), with a case history of 43 months (2 months to 27 years), with the chief complaints of progressive proptosis, disgenesia of the eye ball, and orbit pain, all undergoing transcranial-orbital operation from August 1998 to February. 2006.
  • Recurrence of tumor occurred in 4 cases, and 1 case died from distant metastasis of adenocarcinoma.
  • Adequate orbital apex decompression and exposure of the tumor can result from suitable transcranial-orbital approach.
  • However, complete surgical excision is difficult, and the tumor has a tendency to recur post-operatively.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Skull Base Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cranial Fossa, Anterior. Cranial Fossa, Middle. Craniotomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 16854296.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Arora R, Monga S, Mehta DK, Raina UK, Gogi A, Gupta SD: Malignant fibrous histiocytoma of the conjunctiva. Clin Exp Ophthalmol; 2006 Apr;34(3):275-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They can occur in any part of the body including the orbital tissues.
  • Eleven of these were classified as benign, and the rest were malignant fibrous histiocytomas.
  • Benign fibrous histiocytomas have been reported in the orbit, eyelid, episclera and conjunctiva.
  • Malignant fibrous histiocytoma has been well described in the orbit, but rarely as a primary conjunctival tumour.
  • The rarity of the tumour makes its diagnosis and management a challenge.
  • Herein, the clinicopathological features of a case of malignant fibrous histiocytoma are presented and its management with wide excision and cryotherapy followed by ocular reconstruction with amniotic membrane transplant is discussed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 16671910.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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15. Hirschbein MJ, Collins S, Jean WC, Chang SD, Adler JR Jr: Treatment of intraorbital lesions using the Accuray CyberKnife system. Orbit; 2008;27(2):97-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: This retrospective, non-comparative, interventional case series included 16 patients (6 women and 10 men) with lesions located wholly within the orbit.
  • Thirteen cases involved tumors (31% benign and 69% malignant), two cases presented with chronic orbital inflammation and one patient had intraorbital tissue growth secondary to Graves disease.
  • The main outcome measures analyzed were change in tumor/neoplasm size, pain, visual field preservation and visual acuity, which were followed for up to 15 months.
  • RESULTS: Twelve patients had a postoperative MRI, which revealed either a decrease or stabilization of tumor size.
  • In the five lymphoma cases there was complete disappearance of the tumor.
  • CONCLUSIONS: Staged CyberKnife radiosurgery is an effective option for the treatment of intraorbital lesions that controls tumor size, relieves pain, and preserves vision.
  • [MeSH-major] Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Radiosurgery / instrumentation. Surgery, Computer-Assisted / instrumentation

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  • (PMID = 18415869.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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16. Löffler KU, Holz FG: [Recurrent corneal tumour in a child]. Klin Monbl Augenheilkd; 2007 Sep;224(9):733-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent corneal tumour in a child].
  • We present the clinical and histopathological findings in the unusual case of a recurrent corneal tumour in a child.
  • Light and ultrastructural observations as well as immunohistochemistry indicate a benign reactive process.
  • A possible diagnosis of nodular fasciitis is discussed.
  • [MeSH-major] Corneal Diseases / congenital. Eye Neoplasms / congenital. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Actins / analysis. Astigmatism / diagnosis. Astigmatism / pathology. Child, Preschool. Collagen / ultrastructure. Cornea / pathology. Cornea / surgery. Corneal Stroma / pathology. Corneal Stroma / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Ki-67 Antigen / analysis. Microscopy, Electron. Neoplasm Invasiveness / pathology. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Vimentin / analysis

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  • (PMID = 17846964.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Ki-67 Antigen; 0 / Vimentin; 9007-34-5 / Collagen
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17. Orawiec B, Grałek M, Stefańczyk L, Niwald A: Applicability of ultrasound in ocular tumors in children and adolescents. Klin Oczna; 2005;107(7-9):437-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Applicability of ultrasound in ocular tumors in children and adolescents.
  • PURPOSE: Evaluation of the applicability of ultrasound in children diagnosed for neoplasm of the eye.
  • Evaluation of Doppler ultrasound in visualizing blood vessels within the lesion in eye ball, eye socket and eye lids.
  • Establishing the value of the obtained data concerning the image of vessels and blood flow for the diagnosis, monitoring the course of disease and results of treatment.
  • MATERIAL AND METHODS: The study comprised 80 patients diagnosed and treated for neoplasm of the eye.
  • The presence of vessels in tumor mass and blood flow in tumors were useful for differentiation between malignant and benign tumors.
  • The obtained pictures of vessels and flow character are typical for some tumors, which together with histopathology of tumors enables establishing of correct diagnosis.
  • [MeSH-major] Eye Neoplasms / ultrasonography

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  • (PMID = 16416991.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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18. Kashkouli MB, Khalatbari MR, Yahyavi T, Borghei Razavi H, Shayanfar N, Parvaresh MM: Primary endo-orbital osteoid osteoma. Orbit; 2008;27(3):211-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteiod osteoma is a small, benign, osteoblastic tumor, which usually affects the long bone of the lower extremities and vertebrae.
  • A 22-year-old man presented with eyelid edema, proptosis and pain in the left eye 1 year after the beginning of the symptoms.
  • [MeSH-major] Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Osteoma, Osteoid / pathology. Osteoma, Osteoid / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Exophthalmos / diagnosis. Exophthalmos / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18569832.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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19. Maier PC, Auw-Hädrich C, Reinhard T: [Recurrent fibrous histiocytoma at the corneoscleral limbus]. Klin Monbl Augenheilkd; 2008 Jan;225(1):99-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In our patient the tumour was histologically classified as benign, however, it presented with an invasive growth pattern and recurrency, so that a penetrating sclerokeratoplasty became necessary.
  • [MeSH-major] Corneal Diseases / surgery. Eye Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Keratoplasty, Penetrating. Limbus Corneae / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18236380.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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20. Robinson JW, Brownstein S, Jordan DR, Hodge WG: Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol; 2006 Sep-Oct;51(5):513-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
  • The woman was undergoing mitomycin C injections for ocular cicatricial pemphigoid, diagnosed in the same eye 2 years prior to identification of the neoplasm.
  • The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology. Conjunctivitis / complications. Pemphigoid, Benign Mucous Membrane / complications
  • [MeSH-minor] Basement Membrane / pathology. Biopsy. Drug Therapy, Combination. Female. Fluorometholone / therapeutic use. Humans. Middle Aged. Mitomycin / therapeutic use. Neoplasm Invasiveness. Ofloxacin / therapeutic use


21. Guo ZH, Huang H, DU T, Xu KW, Cao Y, Chen JQ, Dong W, Yao YS, Lin TX, Xie WL, Jiang C, Han JL, Huang J: [Inhibition and significance of pigment epithelium-derived factor in the development and metastasis of prostate cancer]. Zhonghua Yi Xue Za Zhi; 2010 Nov 16;90(42):2980-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The expression of PEDF was examined in the normal prostate tissue, benign prostatic hyperplasia, prostate cancer tissue and prostate cancer cell lines, PC-3 and Lncap by immunohistochemical SP method and Western blot.
  • RESULTS: In normal prostate tissue and benign prostate tissue, the expression of PEDF were elevated and it was far higher than the prostate cancer and prostate cancer cell line.
  • [MeSH-major] Eye Proteins / metabolism. Nerve Growth Factors / metabolism. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Serpins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 21211310.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / Serpins; 0 / pigment epithelium-derived factor
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22. Jakobiec FA, Bhat P, Colby KA: Immunohistochemical studies of conjunctival nevi and melanomas. Arch Ophthalmol; 2010 Feb;128(2):174-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations.
  • CONCLUSIONS: S-100 and MART-1 were not useful in separating benign from malignant lesions.
  • Immunostaining for HMB-45 and Ki-67 are valuable adjuncts to careful histopathologic evaluation in assessing benign and malignant conjunctival melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD45 / analysis. Antigens, Neoplasm / analysis. Child. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • (PMID = 20142539.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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23. Irace C, Davì G, Corona C, Candino M, Usai S, Gambacorta M: Isolated intraorbital schwannoma arising from the abducens nerve. Acta Neurochir (Wien); 2008 Nov;150(11):1209-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient presented with a painless proptosis of the left eye.
  • DISCUSSION: Preoperative diagnosis of benign intraorbital neoplasm was made by means of CT and MR scans; the mass was radically excised through a microsurgical lateral orbitotomy and the pathological examination revealed a schwannoma.
  • [MeSH-major] Abducens Nerve / pathology. Abducens Nerve Diseases / pathology. Cranial Nerve Neoplasms / pathology. Neurilemmoma / pathology. Orbit / pathology

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  • (PMID = 18941708.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers; 0 / S100 Proteins
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24. Koletsa T, Karayannopoulou G, Dereklis D, Vasileiadis I, Papadimitriou CS, Hytiroglou P: Mesectodermal leiomyoma of the ciliary body: report of a case and review of the literature. Pathol Res Pract; 2009;205(2):125-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesectodermal leiomyoma of the ciliary body is a rare benign tumor with double (muscular and neural) differentiation.
  • This neoplasm is considered to originate from the ciliary body smooth muscle, a neural crest derivative.
  • We report a case of mesectodermal leiomyoma of the right eye occurring in a 53-year-old woman, who presented with significant decrease of visual acuity.
  • The tumor measured 1.2cm in greatest dimension, and consisted of spindle and ovoid cells with abundant fibrillary cytoplasmic processes.
  • A review of the 23 cases thus far reported in the literature shows a striking predilection for women, as well as significant difficulties in differentiating this tumor from malignant melanoma on clinical grounds.
  • [MeSH-major] Ciliary Body / pathology. Leiomyoma / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18930601.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Farmer JP, Lamba M, McDonald H, Commons AS: Orbital giant cell angiofibroma: immuno-histochemistry and differential diagnosis. Can J Ophthalmol; 2006 Apr;41(2):216-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital giant cell angiofibroma: immuno-histochemistry and differential diagnosis.
  • COMMENTS: Giant cell angiofibroma is a benign spindle cell neoplasm characterized by multinucleated giant cells and pseudovascular spaces with a propensity to occur in the anterior soft tissues of the orbit of middle-aged adults.
  • It is part of a wide differential diagnosis of tumours that can be separated by various histologic and immunohistochemical features, which are discussed in the report.
  • It is important to consider it preoperatively because the vascular nature of this tumour may create problems with hemostasis during excision.

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  • (PMID = 16767212.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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26. Rohrbach JM, Grüb M, Schlote T: [Neoplastic secondary glaucomas]. Klin Monbl Augenheilkd; 2005 Oct;222(10):788-96
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  • The frequency of IOP-elevation is mainly dependent on the biologic behaviour of the neoplasm (benign / malignant), its dimensions, localization, and its ability to provoke secondary changes like retinal detachment, hemorrhages, inflammation, and necroses.
  • The leading mechanisms are direct invasion of the chamber angle by tumour cells, rubeosis iridis, and forward displacement of the iris-lens-diaphragm with (lens induced) pupillary block.
  • As intraocular tumours may have pressure-lowering effects too, eyes bearing a tumour may also be hypotonic or normotonic inspite of a "glaucomatous chamber angle morphology".
  • The therapy of the tumour-induced glaucomas is hardly validated and generally follows the treatment of the other secondary glaucomas.
  • However, filtration procedures are contraindicated when a malignant tumour is diagnosed or suspected.
  • Because of the progress of tumour therapy with salvation of eyes which had to be enucleated in former times and prolongation of survival in some tumour entities (like Non Hodgkin's lymphoma and metastases) the significance of tumour-induced glaucomas will probably further increase in the future.
  • [MeSH-major] Eye Neoplasms / diagnosis. Eye Neoplasms / therapy. Glaucoma / diagnosis. Glaucoma / therapy

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  • (PMID = 16240271.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 93
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27. Segal A, Segal N, Gal A, Tumuluri K: Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. Orbit; 2010 Dec;29(6):334-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor.
  • In 12(21.8%) patients a lesion with a benign diagnosis was previously excised from the same location.
  • In 2 of them histological re-examination resulted in a diagnosis of MSA.
  • Recurrence of the tumor was reported in 14(30%) patients.
  • CONCLUSIONS: MSA is a rare tumor of the eyelid with no clinically distinguishing features.
  • The tumor may extend into the orbit and metastasize regionally.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mohs Surgery / methods. Neoplasm Staging. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 21158574.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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28. Kim UR, Arora V, Shanti R, Shah AD: Neglected giant atypical fibroxanthoma of the eyelid. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):408-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical fibroxanthoma is an uncommon neoplasm of the superficial soft tissue that occurs in actinically damaged skin of elderly patients.
  • [MeSH-major] Eyelid Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19966663.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Tam ES, Chen EC, Nijhawan N, Harvey JT, Howarth D, Oestreicher JH: Solitary fibrous tumor of the orbit: a case series. Orbit; 2008;27(6):426-31

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  • [Title] Solitary fibrous tumor of the orbit: a case series.
  • PURPOSE: Solitary fibrous tumor (SFT) occurs rarely in the orbit.
  • We present four such cases, representing one of the largest case series reported to date of this rare orbital tumor.
  • METHOD: The four patients ranged from ages 20 to 50, all of whom presented with lid swelling or bulging in the involved eye.
  • All four patients underwent CT scan to confirm the diagnosis of an orbital mass, which was then excised.
  • One of these cases demonstrated residual tumor on follow-up CT scan, which remained unchanged at one-year follow-up.
  • No evidence of residual tumor was found in the other three cases, despite one having malignant pathology.
  • CONCLUSION: SFT is a rare and generally benign tumor of the orbit.
  • Immunohistochemical testing with CD34 is necessary to confirm the diagnosis.
  • Although en bloc tumor resection is the definitive treatment, residual tumor may remain stable for some time.
  • [MeSH-major] Fibroma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 19085297.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
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30. Cohen VM, Shields CL, Furuta M, Shields JA: Vitreous seeding from retinal astrocytoma in three cases. Retina; 2008 Jun;28(6):884-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: An asymptomatic 8-year-old boy (Case 1) presented with a white juxtapapillary retinal tumor and extensive overlying large vitreous seeds.
  • Fine-needle aspiration biopsy (FNAB) confirmed the diagnosis of benign retinal astrocytoma.
  • A 5-year-old boy (Case 2) presented with a large, multilobulated, tan juxtapapillary retinal tumor.
  • Histopathologic analysis of the enucleated globe supported the diagnosis of retinal astrocytoma.
  • The tumor height increased from 2.5 mm to 5.5 mm, and total retinal detachment developed.
  • After enucleation, the diagnosis of retinal astrocytoma was confirmed.
  • CONCLUSIONS: Retinal astrocytoma can produce vitreous seeds, sometimes associated with tumor growth.
  • Care should be taken to exclude the diagnosis of retinoblastoma.
  • [MeSH-major] Astrocytoma / secondary. Eye Neoplasms / secondary. Neoplasm Seeding. Retinal Neoplasms / pathology. Vitreous Body / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Eye Enucleation. Female. Humans. Male. Retrospective Studies

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  • (PMID = 18536607.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. Gracia E, Froesch P, Mazzucchelli L, Martin V, Rodríguez-Abreu D, Jiménez J, Melgares M, Santos D, Capó V, Cavalli F, Zucca E, Bertoni F: Low prevalence of Chlamydia psittaci in ocular adnexal lymphomas from Cuban patients. Leuk Lymphoma; 2007 Jan;48(1):104-8
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  • [Title] Low prevalence of Chlamydia psittaci in ocular adnexal lymphomas from Cuban patients.
  • Most ocular adnexal lymphomas (OAL) are extranodal marginal zone B-cell lymphomas (EMZL) of mucosa-associated lymphoid tissue (MALT)-type.
  • DNA samples were obtained from formalin-fixed, paraffin-embedded sections samples of 26 patients with OAL, 20 non-OAL and 20 benign ocular lesions, diagnosed and treated between 1998 and 2003 at National Institute of Oncology in Havana, Cuba.
  • DNA of C. psittaci was detected in 11% of the 46 lymphomas: two orbital EMZL and three non-OAL.
  • All 20 benign ocular lesions were negative for C. psittaci.
  • [MeSH-major] Chlamydophila psittaci / isolation & purification. Eye Neoplasms / microbiology. Lymphoma, B-Cell / microbiology. Psittacosis / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Caspases / genetics. Cuba / epidemiology. DNA, Bacterial / isolation & purification. Female. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Prevalence. Retrospective Studies

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  • (PMID = 17325853.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / Neoplasm Proteins; EC 3.4.22.- / Caspases; EC 3.4.22.- / MALT1 protein, human
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32. Finger PT, Kurli M, Reddy S, Tena LB, Pavlick AC: Whole body PET/CT for initial staging of choroidal melanoma. Br J Ophthalmol; 2005 Oct;89(10):1270-4
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  • METHODS: 52 patients with choroidal melanoma underwent whole body PET/CT as part of their metastatic investigation.
  • PET/CT scans were used as a screening tool at the time of their initial diagnosis.
  • In seven patients (13.4%) PET/CT imaging detected benign lesions in the bone, lung, lymph nodes, colon, and rectum.
  • [MeSH-major] Choroid Neoplasms / pathology. Melanoma / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / radiography. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Female. Fluorodeoxyglucose F18. Humans. Liver Neoplasms / radiography. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography / methods. Radiopharmaceuticals. Spinal Neoplasms / radiography. Spinal Neoplasms / radionuclide imaging. Spinal Neoplasms / secondary. Tomography, X-Ray Computed / methods

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  • (PMID = 16170114.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC1772897
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33. Livaoĝlu M, Cakir E, Karaçal N: Large orbital osteoma arising from orbital roof: Excision through an upper blepharoplasty incision. Orbit; 2009;28(2-3):200-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoma is the most common benign tumor of facial bony structure.
  • The patient's ophtalmological examination revealed; only light perception due to the severe amblyopia and posterior capsular opacification in the right eye, and complete visual acuity in the left.
  • His left eye was proptotic and directed to downward lateral gaze position.
  • There were not any postoperative complications and all ocular symptoms in the left eye were resolved after 1 month.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Orbital Neoplasms / surgery. Osteoma / diagnosis. Osteoma / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoplasty / methods. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Ophthalmologic Surgical Procedures / methods. Risk Assessment. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19839914.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Currie ZI, Rose GE: Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol; 2007 Dec;125(12):1643-6
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  • METHODS: Medical records were reviewed for 133 patients and only those patients with 5 years or more of follow up were classified into the following 5 subgroups: those with intact excision (group IA, n = 46), those with surgically intact excision but areas of complete attenuation of the pseudocapsule at histologic analysis (group IB, n = 7), those with previous inadvertent incisional biopsy (group IIA, n = 9), those with breach of the pseudocapsule during attempted intact excision (group IIB, n = 5), and those undergoing definitive surgery because of tumor recurrence after previous incomplete excision (group III, n = 5).
  • RESULTS: Seventy-two patients were followed up longer than 5 years; there were no known tumor recurrences among 61 patients excluded with shorter follow-up.
  • Patients in groups IA and IB exhibited no tumor recurrences at 8.2 to 34.1 years of follow-up.
  • A benign recurrence occurred along the superior orbital fissure in 1 patient in group IIA 12(1/2) years after the initial surgery and was resected.
  • Long-term follow-up is, however, necessary when there has been tumor disruption, either inadvertently during previous biopsy or by capsular breach during definitive excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Eye Neoplasms. Female. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 18071115.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Wang WH, Lee SS, Wang LF, Lai CS: Repair oronasal fistula in a treated juvenile nasopharyngeal angiofibroma patient. J Plast Reconstr Aesthet Surg; 2007;60(10):1148-51
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  • OBJECTIVE: The juvenile nasopharyngeal angiofibroma (JNA) is a benign neoplasm that affects mostly young males.
  • Right side hemiplegia and left eye blindness were noted.
  • [MeSH-major] Angiofibroma / surgery. Fistula / surgery. Nasopharyngeal Neoplasms / surgery. Nose Diseases / surgery. Oral Fistula / surgery

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  • (PMID = 17825778.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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36. Durkin SR, Roos D, Higgs B, Casson RJ, Selva D: Ophthalmic and adnexal complications of radiotherapy. Acta Ophthalmol Scand; 2007 May;85(3):240-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This growth has seen an expansion of indications for radiotherapy, a refinement of the modalities that can be used and a reduction in the ocular and adnexal complications that result from this form of therapy.
  • The compendium of indications for radiotherapy in ophthalmology continues to grow and now includes many conditions such as the treatment of lid and adnexal disease, ocular surface disorders and both benign and malignant disease of the posterior segment and optic pathways.
  • New techniques such as stereotactic radiosurgery are delivering benefits in the management of conditions such as optic nerve sheath meningioma, where the treatment of this blinding and occasionally life-threatening intracranial neoplasm now results in fewer adverse affects.
  • The purpose of this review is to give a brief overview of the indications and treatment modalities, and a more in-depth discussion of the potential side-effects when radiotherapy is used for ocular and periorbital disease.
  • [MeSH-major] Eye Diseases / etiology. Eye Diseases / radiotherapy. Lacrimal Apparatus Diseases / etiology. Neoplasms, Radiation-Induced / etiology. Osteoradionecrosis / etiology. Radiation Injuries / etiology. Radiodermatitis / etiology

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  • (PMID = 17488452.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 130
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37. Amoli FA, Mehrabani PM, Tari AS: Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit; 2007 Dec;26(4):271-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive orbital optic nerve meningioma with benign microscopic features: a case report.
  • The patient had a history of orbital meningioma from 10 years ago and several surgical resections due to tumor recurrence during these 10 years.
  • Fine-needle aspiration cytology of the mass confirmed tumor recurrence.
  • The patient first received radiotherapy due to the inoperable mass, and the tumor was resected 1.5 month later.
  • The interesting aspect of this case was the aggressive behavior of the tumor with intraocular invasion, despite its benign histopathological features, which led to wide exenteration of the eye together with resection of the upper and lower lids.
  • [MeSH-major] Meningioma / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 18097966.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Tamura K, Aoyagi M, Wakimoto H, Tamaki M, Yamamoto K, Yamamoto M, Ohno K: Malignant transformation eight years after removal of a benign epidermoid cyst: a case report. J Neurooncol; 2006 Aug;79(1):67-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation eight years after removal of a benign epidermoid cyst: a case report.
  • Malignant transformation of benign epidermoid cysts is rare and their prognosis remains poor.
  • A 56-year-old woman presented with left facial hypoesthesia and photophobia in the left eye.
  • She had undergone removal of a benign epidermoid cyst in the cerebellopontine angle 8 years previously.
  • She underwent removal again and the histopathologic diagnosis was squamous cell carcinoma.
  • The tumor shrank rapidly for 2 months after radiosurgery, but recurred 9 months later.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Epidermal Cyst / pathology
  • [MeSH-minor] Female. Gadolinium. Humans. Image Enhancement. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Radiosurgery

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  • (PMID = 16583265.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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39. Zhang J, Jianmin, Wang N: Pigmented neurofibroma in the superciliary arch. BMJ Case Rep; 2009;2009

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  • Pigmented neurofibroma is a rare, benign neoplasm arising from the neural crest.
  • The clinical and histological diagnosis is often difficult to make.

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  • (PMID = 22190984.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028248
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40. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Facial Paralysis / etiology. Parotid Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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41. Jakobiec FA, Nguyen J, Bhat P, Fay A: Recurrent blue nevus of the corneoscleral limbus. Cornea; 2010 Aug;29(8):947-51
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  • The Ki-67 proliferation index was very low (0.05%), supporting a benign diagnosis.
  • CONCLUSIONS: Careful histopathological and immunohistochemical evaluation of recurrent, incompletely excised, blue nevi can determine if they remain benign.
  • [MeSH-major] Corneal Diseases / surgery. Eye Neoplasms / surgery. Neoplasm Recurrence, Local. Nevus, Blue / surgery. Scleral Diseases / surgery
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Cryotherapy. Female. Humans. Sclerostomy

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  • (PMID = 20508501.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. Igaki T, Pagliarini RA, Xu T: Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol; 2006 Jun 6;16(11):1139-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.
  • However, the underlying mechanisms of how cell polarity disruption contributes to tumor progression are unknown.
  • Here, using a Drosophila genetic model for Ras-induced tumor progression, we show a molecular link between loss of cell polarity and tumor malignancy.
  • Mutation of different apicobasal polarity genes activates c-Jun N-terminal kinase (JNK) signaling and downregulates the E-cadherin/beta-catenin adhesion complex, both of which are necessary and sufficient to cause oncogenic Ras(V12)-induced benign tumors in the developing eye to exhibit metastatic behavior.
  • Furthermore, activated JNK and Ras signaling cooperate in promoting tumor growth cell autonomously, as JNK signaling switches its proapoptotic role to a progrowth effect in the presence of oncogenic Ras.
  • Our finding that such context-dependent alterations promote both tumor growth and metastatic behavior suggests that metastasis-promoting mutations may be selected for based primarily on their growth-promoting capabilities.
  • [MeSH-major] Drosophila / enzymology. Drosophila Proteins / metabolism. JNK Mitogen-Activated Protein Kinases / metabolism. Neoplasms, Experimental / enzymology
  • [MeSH-minor] Animals. Apoptosis / genetics. Cadherins / metabolism. Cell Polarity / genetics. Disease Models, Animal. Enzyme Activation. Eye / pathology. Neoplasm Metastasis. Proto-Oncogene Proteins p21(ras) / metabolism. Signal Transduction. beta Catenin / metabolism

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  • (PMID = 16753569.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Drosophila Proteins; 0 / beta Catenin; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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43. Perlmann E, da Silva EG, Guedes PM, Barros PS: Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat. Vet Ophthalmol; 2010 Jan;13(1):63-6
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  • [Title] Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat.
  • A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye.
  • Ophthalmic examination revealed a blind right eye and presence of two distinct masses: a pink and a red-to-brown mass, the latter occupying most of the cornea and part of the conjunctiva.
  • Exenteration was performed under general anesthesia, and the ocular tissues were processed routinely for histopathology.
  • Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea.
  • Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
  • A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made.
  • To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Cat Diseases / pathology. Eye Neoplasms / veterinary. Hemangioma / veterinary. Neoplasms, Multiple Primary / veterinary

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  • (PMID = 20149179.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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44. Shields JA, Eagle RC Jr, Shields CL, Brown GC, Lally SE: Malignant transformation of congenital hypertrophy of the retinal pigment epithelium. Ophthalmology; 2009 Nov;116(11):2213-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A 56-year-old black woman was referred for an asymptomatic fundus lesion in her left eye.
  • It had features typical of CHRPE, but there was a small elevated nodule within the flat component, and the diagnosis was adenoma of the retinal pigment epithelium (RPE) arising from CHRPE.
  • Thirteen years after the initial diagnosis, the patient returned with severe visual loss and no view of the fundus resulting from cataract and posterior synechia.
  • Ultrasonography revealed a total retinal detachment and a pedunculated tumor measuring 7.5 mm in thickness.
  • The eye was enucleated and studied histopathologically.
  • MAIN OUTCOME MEASURES: Clinical evaluation and correlation of clinical findings with histopathologic results of the enucleated eye.
  • RESULTS: Histopathologically, the mass was composed of a proliferation of atypical RPE cells with a marked infiltration of benign plasma cells.
  • Typical features of CHRPE were present at the base of the tumor.
  • The final diagnosis was adenocarcinoma arising from CHRPE.
  • CONCLUSIONS: Congenital hypertrophy of the retinal pigment epithelium, once considered to be a benign and stationary lesion, may spawn a malignant neoplasm.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Transformation, Neoplastic / pathology. Retinal Neoplasms / pathology. Retinal Pigment Epithelium / pathology
  • [MeSH-minor] Eye Enucleation. Female. Humans. Hypertrophy / congenital. Middle Aged. Retinal Detachment / pathology. Retinal Detachment / ultrasonography

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  • (PMID = 19744732.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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45. Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22

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  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient.
  • Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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46. Morris DS, Fayers T, Dolman PJ: Orbital teratoma: case report and management review. J AAPOS; 2009 Dec;13(6):605-7
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  • We present a case of benign mature orbital teratoma in a neonatal boy that involved the chiasmal area and cavernous sinus and displaced the nasopharynx.
  • A debulking procedure, mainly of the cystic parts of the tumor, was performed.
  • The patient remains stable at 3 years of age, with no further growth of the tumor and good vision in the affected eye.

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  • (PMID = 20006828.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med; 2008;4:18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis.
  • Diagnosis is often delayed due to its variable and often benign clinical appearance.
  • CASE PRESENTATION: This case presents a 64-year-old man with a six-month-history of a recurrent diffuse and erythematous painless swelling below the left eye.
  • Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis.
  • [MeSH-major] Facial Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18694495.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2533304
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48. Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS: Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi. Ophthalmology; 2007 Apr;114(4):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.
  • METHODS: Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds.
  • MAIN OUTCOME MEASURES: Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma.
  • No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF.
  • Seven out of 10 siblings had a history of cutaneous and/or ocular nevi.
  • Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma).
  • Three of the 10 siblings had relevant ocular findings (2 choroidal nevi, 1 uveal melanoma).
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Pedigree. Risk Factors. Sequence Analysis, DNA. Surveys and Questionnaires. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17207529.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p14ARF
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49. Zhao P, Sun XL: [Clinical use of quantitative DNA pathologic examination in eye neoplasms]. Zhonghua Yan Ke Za Zhi; 2005 Oct;41(10):957-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical use of quantitative DNA pathologic examination in eye neoplasms].
  • Quantitative determination of DNA in tumor cells as an objective quantitative index reflecting biological behavior of tumor cells and has an important significance for distinguishing precancerous lesions, borderline tumors, benign and malignant tumors; and for estimating the malignant degree and prognosis.
  • This review introduces the study about DNA quantitative analysis used in clinical pathology of eye neoplasms.
  • [MeSH-major] DNA, Neoplasm / analysis. Eye Neoplasms / pathology

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  • (PMID = 16271190.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 27
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50. Jakobiec FA, Colby K, Bajart AM, Saragas SJ, Moulin A: Immunohistochemical studies of atypical conjunctival melanocytic nevi. Arch Ophthalmol; 2009 Aug;127(8):970-80
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  • Ki-67 was the most valuable immunohistochemical adjunct to morphology for the diagnosis of these benign variant conjunctival nevi, because melanomas display a much higher proliferation index (>10% nuclear positivity among all cells counted) than the current nevi (approximately 1%).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Conjunctival Neoplasms / metabolism. Neoplasm Proteins / metabolism. Nevus, Blue / metabolism. Nevus, Pigmented / metabolism
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, Neoplasm / metabolism. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / metabolism. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Muramidase / metabolism. Retrospective Studies. S100 Proteins / metabolism. Young Adult

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  • (PMID = 19667333.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.2.1.17 / Muramidase
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51. Golub JS, Parikh SL, Budnick SD, Bernardino CR, DelGaudio JM: Inverted papilloma of the nasolacrimal system invading the orbit. Ophthal Plast Reconstr Surg; 2007 Mar-Apr;23(2):151-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 73-year-old man with a history of epiphora, discharge from the left eye, and left-sided nasal congestion underwent external dacryocystorhinostomy for nasolacrimal duct obstruction.
  • This case illustrates the importance of including inverted papilloma, a benign but invasive neoplasm, in the differential diagnosis of nasolacrimal duct obstruction.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Nasolacrimal Duct / pathology. Orbital Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Aged. Dacryocystorhinostomy. Humans. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17413635.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Yao J, Chen RJ, Sun XH: [Analysis of the relationship between pathology and recurrence of primary lacrimal epithelial tumors]. Zhonghua Yan Ke Za Zhi; 2006 Jul;42(7):590-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: 128 cases of primary lacrimal epithelial tumors including benign mixed tumor (74 cases, 57.8%), adenoid cystic carcinoma (22 cases, 17.2%) and malignant mixed tumor (18 cases, 14.1%) were subjected in the study.
  • RESULTS: The recurrent rate of benign mixed tumor, adenoid cystic carcinoma and malignant mixed tumor was 23.0%, 18.2% and 27.8%, respectively.
  • The recurrence of benign mixed tumor was statistically related to pathological classification and encapsulates.
  • The pathological features were decisive in diagnosis, selection of treatment and the time of follow-up.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17081415.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Boonman ZF, van Mierlo GJ, Fransen MF, de Keizer RJ, Jager MJ, Melief CJ, Toes RE: Maintenance of immune tolerance depends on normal tissue homeostasis. J Immunol; 2005 Oct 1;175(7):4247-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we analyzed whether tolerance toward an intraocular tumor expressing a highly immunogenic CTL epitope is maintained, broken, or reverted into immunity in the event the anatomical integrity of the eye is lost.
  • Inoculation of tumor cells into the anterior chamber of the eye of naive B6 mice leads to progressive intraocular tumor growth, an abortive form of CTL activation in the tumor-draining submandibular lymph node, and systemic tolerance as evidenced by the inability of these mice to reject an otherwise benign tumor cell inoculum.
  • Loss of anatomical integrity of the eye as a consequence of phthisis resulted in loss of systemic tolerance and the emergence of effective antitumor immunity against an otherwise lethal tumor challenge.
  • Phthisis was accompanied by dendritic cell maturation and preceded the induction of systemic tumor-specific CTL immunity.
  • Our data show that normal tissue homeostasis and anatomical integrity is required for the maintenance of ocular tolerance and prevention of CTL-mediated immunity.
  • [MeSH-major] Eye Neoplasms / immunology. Homeostasis / immunology. Immune Tolerance / physiology
  • [MeSH-minor] Animals. Anterior Chamber / immunology. Antigen Presentation / immunology. Antigen-Presenting Cells / metabolism. Antigens, CD11c / metabolism. Antigens, Neoplasm / immunology. Cell Line, Transformed. Cell Line, Tumor. Cross-Priming / immunology. Mice. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 16177064.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / Antigens, Neoplasm
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54. Milker-Zabel S, Zabel-du Bois A, Huber P, Schlegel W, Debus J: Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas : long-term experience and review of the literature. Strahlenther Onkol; 2006 Nov;182(11):635-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas : long-term experience and review of the literature.
  • PURPOSE: To analyze own long-term results with fractionated stereotactic radiotherapy (FSRT) in patients with benign meningiomas of the cavernous sinus and to review the literature on these rare lesions.
  • PATIENTS AND METHODS: 57 patients were treated with FSRT for benign meningiomas of the cavernous sinus between 01/1990 and 12/2003 at the authors' institution.
  • Overall local tumor control was 100%.
  • 39/57 patients had stable disease based on CT/MRI, while 18/57 had a partial remission of tumor volume.
  • There was one patient with recurrent hyperlacrimation of one eye on the side of the irradiated meningioma.
  • CONCLUSION: These data demonstrate that FSRT is an effective and safe treatment modality for local control of benign cavernous sinus meningiomas with a minimal risk of significant late toxicity.
  • [MeSH-major] Cavernous Sinus. Dose Fractionation. Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy
  • [MeSH-minor] Follow-Up Studies. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / radiotherapy. Radiosurgery. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Remission Induction. Safety. Stereotaxic Techniques. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17072520.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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55. Jakobiec FA, Nguyen J, Bhat P, Fay A: MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):413-5
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  • [Title] MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit.
  • PURPOSE: To distinguish, in a 36-year-old man, an atypical lipomatous neoplasm/well-differentiated liposarcoma from a spindle cell lipoma in a recurrent orbital tumor.
  • RESULTS: MDM2 gene amplification was discovered in the CD34 tumor cells.
  • These findings established the diagnosis of a well-differentiated liposarcoma with lipoma-like and spindle cell features and ruled out a spindle cell lipoma.
  • CONCLUSION: Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging.
  • It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbital Neoplasms / diagnosis. Proto-Oncogene Proteins c-mdm2 / analysis

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  • (PMID = 20639786.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 9013-56-3 / Factor XIII; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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56. Bolzoni A, Pianta L, Farina D, Nicolai P: Benign myoepithelioma of the lacrimal gland: report of a case. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):186-8
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  • [Title] Benign myoepithelioma of the lacrimal gland: report of a case.
  • We herein report the radiological, clinical and histopathological evaluation of a 46-year-old patient with a history of right eye proptosis and progressive diplopia.
  • A mass in the right lacrimal fossa was detected at MRI and turned out to be benign myoepithelioma of the lacrimal gland at the histopathological examination.
  • The lesion was entirely removed "en-bloc" with the lacrimal gland.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Myoepithelioma / pathology
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Surgical Procedures, Operative / methods

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  • (PMID = 15138773.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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57. He MX, Song B, Jiang H, Hu XG, Zhang YJ, Zheng JM: Complete resection of isolated pancreatic metastatic melanoma: a case report and review of the literature. World J Gastroenterol; 2010 Sep 28;16(36):4621-4
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  • We present a case of a 39-year-old Chinese male with a solitary pancreatic tumor which was considered a cystic benign lesion for years.
  • Pathology and immunohistochemistry showed that the tumor in pancreatic tail was a metastasis from a malignant melanoma of the eyeball.
  • The tumor was completely resected with combined distal pancreatectomy and splenectomy.
  • [MeSH-major] Eye Neoplasms / pathology. Melanoma. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Metastasis

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  • (PMID = 20857537.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2945498
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58. Liao Y, Zeng H, Wang X, Huang Y, Chen N, Ge B, Tang L, Luo Q: Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland. Exp Eye Res; 2009 Jan;88(1):4-11
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  • Adenoid cystic carcinoma (ACC) of lachrymal gland is a malignant tumor with a poor prognosis, while, pleomorphic adenoma (PA) is the benign tumor of lachrymal gland epithelia.
  • Livin expression was almost undetectable in both malignancy and benign lesion of lachrymal gland.
  • Overexpression of Survivin in ACC was associated with poorer survival, which may have clinical impact on diagnosis and therapeutic considerations of this malignancy.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Inhibitor of Apoptosis Proteins / metabolism. Lacrimal Apparatus Diseases / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Gene Expression. Humans. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Paraffin Embedding. Prognosis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Analysis. Young Adult

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  • (PMID = 18955046.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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59. Kaufman LM, Doroftei O: Optic glioma warranting treatment in children. Eye (Lond); 2006 Oct;20(10):1149-64
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  • One patient was successfully treated with an en-bloc optic nerve excision.
  • CONCLUSION: Although benign tumours, OPG can behave very aggressively in young children.
  • Both chemotherapy and en-bloc excision can be employed for treatment.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Disease Progression. Exophthalmos / etiology. Eye Enucleation. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neurofibromatosis 1 / complications. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / therapy. Optic Nerve / pathology. Optic Nerve / surgery. Retrospective Studies. Treatment Outcome. Vision Disorders / etiology

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  • (PMID = 17019413.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 1792
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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60. Kurli M, Reddy S, Tena LB, Pavlick AC, Finger PT: Whole body positron emission tomography/computed tomography staging of metastatic choroidal melanoma. Am J Ophthalmol; 2005 Aug;140(2):193-9
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  • DESIGN: Interventional non-randomized clinical study.
  • Two were imaged before treatment of their primary tumor.
  • The mean time from initial diagnosis to metastasis was 47 months (range 0 to 154).
  • PET/computed tomography imaging also detected benign lesions of the bone and lymph nodes in three patients (15%).
  • [MeSH-major] Choroid Neoplasms / pathology. Choroid Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Melanoma / secondary. Positron-Emission Tomography / methods. Whole-Body Counting / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Female. Fluorodeoxyglucose F18. Humans. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Lung Neoplasms / radionuclide imaging. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 15992753.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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61. McKenna M, Brodsky L: Extraesophageal acid reflux and recurrent respiratory papilloma in children. Int J Pediatr Otorhinolaryngol; 2005 May;69(5):597-605
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  • OBJECTIVE: Recurrent respiratory papillomatosis (RRP) is a benign infectious disease which is caused by the human papilloma virus (HPV).
  • The clinical course of the papillomatosis and the diagnosis and treatment of reflux are compared over time.
  • Prompt diagnosis and effective treatment of EERD should be considered in all patients with difficult to control RRP or with clinical presentation or endoscopic signs of EERD.
  • [MeSH-major] Gastroesophageal Reflux / complications. Gastroesophageal Reflux / diagnosis. Laryngeal Neoplasms / complications. Neoplasm Recurrence, Local / complications. Papilloma / complications
  • [MeSH-minor] Airway Obstruction / etiology. Airway Obstruction / therapy. Child. Child, Preschool. Humans. Male. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / therapy. Severity of Illness Index. Tumor Virus Infections / complications. Tumor Virus Infections / therapy

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  • [CommentIn] Int J Pediatr Otorhinolaryngol. 2006 Apr;70(4):757-8; author reply 759 [16242786.001]
  • (PMID = 15850681.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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62. Okada F, Shionoya H, Kobayashi M, Kobayashi T, Tazawa H, Onuma K, Iuchi Y, Matsubara N, Ijichi T, Dugas B, Hosokawa M: Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase. Br J Cancer; 2006 Mar 27;94(6):854-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase.
  • In the oxykine group, tumour incidence was lower (41%) than in the gliadin or saline group (83 and 79%, respectively).
  • When perfused in situ with nitroblue tetrazolium, an indicator of superoxide formation, the tumour masses from gliadin and saline groups displayed intense formazan deposition, whereas, those from oxykine group had less deposition.
  • Arising tumour cells in gliadin and saline groups acquired metastatic phenotype, but those in oxykine group showed reduced metastatic ability.
  • These results suggested that the orally active SOD derivative prevented tumour progression promoted by inflammation, which is thought to be through scavenging inflammatory cell-derived superoxide anion.
  • [MeSH-major] Fibrosarcoma / immunology. Fibrosarcoma / pathology. Inflammation. Neoplasm Metastasis / immunology. Superoxide Dismutase / metabolism

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  • (PMID = 16508635.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC2361372
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63. Palazzi MA, Ober MD, Abreu HF, Cardinalli IA, Isaac CR, Odashiro AN, Burnier Jr MN: Congenital uveal malignant melanoma: a case report. Can J Ophthalmol; 2005 Oct;40(5):611-5
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  • Enucleation performed in the first weeks of life confirmed the diagnosis of diffuse uveal malignant melanoma with extraocular extension.
  • He subsequently developed cutaneous and ocular pigmented lesions, including 2 choroidal nevi located within the posterior pole and a benign conjunctival lesion in the opposite eye, in addition to malignant melanoma of the skin.
  • We believe this represents the fourth case ever reported in the literature and the longest follow-up of a congenital malignant melanoma originating within the eye.

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  • (PMID = 16391626.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
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64. Charles NC, Lisman RD, Lelli GJ Jr: Subperiosteal orbital fibroma. Ophthalmic Surg Lasers Imaging; 2008 Nov-Dec;39(6):517-8
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  • Pathologic examination showed a benign fibroma, a lesion that to the authors' knowledge has never been previously reported in this location.
  • [MeSH-major] Fibroma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Neoplasm Proteins / analysis

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  • (PMID = 19065988.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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65. Han Z, Lin GJ, Chi FL, Wang SY, Huang JM, Liu HJ, Zhang LR: The relationship between the extracellular matrix and the angiogenesis and metastasis of laryngeal carcinoma. ORL J Otorhinolaryngol Relat Spec; 2008;70(6):352-8
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  • METHODS: Thirty-three cases of benign and malignant laryngeal tumors were included.
  • RESULTS: The expression of ECM1 (p = 0.004) and HA (p = 0.036) was significantly different between benign and malignant tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / secondary. Extracellular Matrix Proteins / metabolism. Laryngeal Neoplasms / pathology. Neovascularization, Pathologic / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Metastasis. Neoplasm Staging. Probability. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Statistics, Nonparametric. Survival Analysis

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18984970.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ECM1 protein, human; 0 / Extracellular Matrix Proteins
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66. Buac K, Xu M, Cronin J, Weeraratna AT, Hewitt SM, Pavan WJ: NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation. Pigment Cell Melanoma Res; 2009 Dec;22(6):773-84
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  • ERBB3 activation in primary melanomas suggests that NRG1/ERBB3 signaling may contribute to the progression of melanoma from benign nevi to malignancies.
  • [MeSH-minor] Animals. Cell Line. Embryo, Mammalian / anatomy & histology. Embryo, Mammalian / physiology. Humans. Melanins / biosynthesis. Membrane Glycoproteins / metabolism. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Microphthalmia-Associated Transcription Factor / genetics. Microphthalmia-Associated Transcription Factor / metabolism. Monophenol Monooxygenase / metabolism. Neoplasm Invasiveness. Oxidoreductases / metabolism. Tissue Array Analysis

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  • (PMID = 19659570.001).
  • [ISSN] 1755-148X
  • [Journal-full-title] Pigment cell & melanoma research
  • [ISO-abbreviation] Pigment Cell Melanoma Res
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HG000136-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Melanins; 0 / Membrane Glycoproteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mitf protein, mouse; 0 / Neuregulin-1; EC 1.- / Oxidoreductases; EC 1.14.18.- / TYRP1 protein, human; EC 1.14.18.1 / Monophenol Monooxygenase; EC 2.7.10.1 / Receptor, ErbB-3
  • [Other-IDs] NLM/ NIHMS144265; NLM/ PMC3023175
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67. Bajaj MS, Pushker N, Kashyap S, Sen S, Vengayil S, Chaturvedi A: Fibrous histiocytoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2007 Mar-Apr;23(2):145-7
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  • Fibrous histiocytoma, a primary mesenchymal tumor of the orbit, is known to arise from various ocular and adnexal tissues.
  • We are unable to find a published report of this tumor originating from the lacrimal gland.
  • We report a case of a benign fibrous histiocytoma of the lacrimal gland in an 11 year old girl who presented with painless, progressive eyelid swelling and mild proptosis.
  • The tumor was completely excised by anterolateral orbitotomy.
  • Light microscopy showed a spindle cell tumor arising from the lacrimal gland.
  • The tumor cells were arranged in a characteristic storiform (cartwheel) pattern with no pleomorphism or mitotic figures.
  • Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma.
  • Based on these features, a diagnosis of benign fibrous histiocytoma was made.
  • [MeSH-major] Eye Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Lacrimal Apparatus Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Humans. Neoplasm Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 17413632.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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68. Lanuza García A, López Ramos AL, Pinto Bonilla JC, Rodríguez Pereira C, Cortés Vizcaíno V: [Management of lymphoid hyperplasia of the ocular adnexa]. Arch Soc Esp Oftalmol; 2005 Jun;80(6):353-8
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  • [Title] [Management of lymphoid hyperplasia of the ocular adnexa].
  • [Transliterated title] Manejo de las hiperplasias linfoides orbitarias.
  • OBJECTIVE: Lymphoid Hyperplasia (LH) is a benign proliferative lymphocyte-rich process.
  • METHOD: We describe three patients with a lymphoproliferative process affecting the ocular anexae, in whom histologic, immuno-histochemical and molecular studies were performed.
  • PCR analysis allowed a definitive diagnosis to be made.
  • After PCR analysis, one of these latter two cases was definitively diagnosed as B-cell Non-Hodgkin's lymphoma.
  • CONCLUSIONS: Today's molecular techniques allow us to make a definite diagnosis of lymphoma, because sometimes histology and immuno-histochemistry alone can result in a wrong diagnosis being made.
  • LH of the ocular adnexae may be the first stage of a much more serious disease, and a benign hyperplasia at this site must lead to suspicion of lymphoma, which can then be diagnosed or excluded by the improved diagnostic procedures.
  • Therefore, when we make a diagnosis of LH it is necessary to complete a full evaluation and institute a defined follow-up of the patient's clinical condition.
  • [MeSH-major] Eye Neoplasms / diagnosis. Lacrimal Apparatus / pathology. Lymphoma, B-Cell / diagnosis. Orbital Diseases / diagnosis. Pseudolymphoma / diagnosis
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Aged. Child. Corneal Opacity / complications. Corneal Opacity / congenital. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. Male. Neoplasm Proteins / genetics. Polymerase Chain Reaction. Retrospective Studies

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  • (PMID = 15986276.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins
  • [Number-of-references] 10
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69. Raemdonck TY, Van den Broecke CM, Claerhout I, Decock CE: Inverted papilloma arising primarily from the lacrimal sac. Orbit; 2009;28(2-3):181-4
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  • A 24-year-old female was referred with epiphora and a non-tender swelling within the right lacrimal fossa, present for 6 months.
  • An IP is a benign but infiltrative epithelial neoplasm with malignant potential characterised by a high recurrence rate.
  • [MeSH-major] Dacryocystorhinostomy / methods. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Contrast Media. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Invasiveness / pathology. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed / methods. Treatment Outcome. Young Adult

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  • (PMID = 19839908.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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70. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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71. Lindegaard J, Heegaard S, Toft PB, Nysom K, Prause JU: Malignant transformation of a medulloepithelioma of the optic nerve. Orbit; 2010 Jun;29(3):161-4
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  • METHODS: A 3-year-old boy presented with right-sided proptosis, swollen eyelids, restricted ocular movements, pain and nausea.
  • A benign non-teratoid medulloepithelioma of the optic nerve was surgically removed.
  • This is the first case described of a benign medulloepithelioma of the optic nerve, later transforming into a malignant tumour.
  • Furthermore; it should be considered as a differential diagnosis when observing a tumour of the optic nerve in a child.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumors, Primitive / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Child, Preschool. Exophthalmos / diagnosis. Exophthalmos / etiology. Eye Enucleation / methods. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Orbit Evisceration / methods. Radiotherapy, Adjuvant. Risk Assessment. Stem Cell Transplantation. Treatment Outcome

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  • (PMID = 20497085.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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72. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • METHODS: Clinicopathologic series of 6 cases, diagnosed at the New York Eye and Ear Infirmary from 1990 to 2006.
  • Most cases had a preoperative diagnosis of basal cell carcinoma or cyst.
  • None of the lesions was associated with a malignant neoplasm.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.
  • [MeSH-major] Cystadenoma / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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73. Cohen AB, Lessell S: Angiogenesis and pituitary tumors. Semin Ophthalmol; 2009 May-Jun;24(3):185-9
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  • They are typically slow-growing and histologically benign tumors, but can become clinically destructive, invade adjacent structures, and recur after treatment.
  • Unlike many other tumors that become aggressive and appear to depend upon angiogenesis in the process, pituitary adenomas tend to do so through non-angiogenic means.
  • [MeSH-major] Neovascularization, Pathologic. Pituitary Neoplasms / blood supply
  • [MeSH-minor] Adenoma / blood supply. Adenoma / metabolism. Adenoma / pathology. Animals. Biomarkers, Tumor / biosynthesis. Blood Vessels / pathology. Humans. Neoplasm Invasiveness. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 19437356.001).
  • [ISSN] 1744-5205
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 22
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74. Cho YJ, Won JB, Byeon SH, Yang WI, Koh HJ, Kwon OW, Lee SC: A choroidal schwannoma confirmed by surgical excision. Korean J Ophthalmol; 2009 Mar;23(1):49-52
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  • A 30-year-old woman presented with a large nonpigmented intraocular mass of the choroid in the right eye and underwent surgical excision by sclerouvectomy.
  • Histologically, the tumor was composed of a mixture of cellular solid components (Antoni A) and loose myxoid components (Antoni B).
  • The tumor was eventually diagnosed as a schwannoma.
  • In the case of atypical findings for a malignant melanoma, a benign neoplasm should be included in the differential diagnosis.
  • [MeSH-major] Choroid / pathology. Choroid Neoplasms / diagnosis. Eye Enucleation / methods. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19337481.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2655748
  • [Keywords] NOTNLM ; Enucleation / Schwannoma / Sclerouvectomy
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