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1. Bahnson TD: Strategies to minimize the risk of esophageal injury during catheter ablation for atrial fibrillation. Pacing Clin Electrophysiol; 2009 Feb;32(2):248-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Strategies to minimize the risk of esophageal injury during catheter ablation for atrial fibrillation.
  • Esophageal injury is a rare but serious complication of catheter ablation for atrial fibrillation using radiofrequency energy.
  • Recent studies have begun to identify variables that may determine heat transfer to and thermal injury of the esophagus.
  • There is significant variability in the relationship between the esophagus and left atrium among individuals.
  • New imaging techniques can facilitate assessment of esophagus position relative to intended ablation targets.
  • Strategies to minimize the risk of esophageal injury include avoidance of ablation near the esophagus, titration of RF energy delivery at the posterior left atrial endocardium, and the use of alternative ablation methods.
  • [MeSH-major] Atrial Fibrillation / surgery. Catheter Ablation / adverse effects. Esophagus / injuries. Surgery, Computer-Assisted / methods. Wounds, Penetrating / prevention & control

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  • (PMID = 19170916.001).
  • [ISSN] 1540-8159
  • [Journal-full-title] Pacing and clinical electrophysiology : PACE
  • [ISO-abbreviation] Pacing Clin Electrophysiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 58
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2. Roorda AK, Triadafilopoulos G: Circumferential and focal radiofrequency ablation for the treatment of Barrett's esophagus. Expert Rev Gastroenterol Hepatol; 2008 Oct;2(5):627-34
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  • [Title] Circumferential and focal radiofrequency ablation for the treatment of Barrett's esophagus.
  • This invited profile summarizes the technical aspects and clinical trial results related to the use of circumferential and focal radiofrequency ablation in the management algorithm for Barrett's esophagus.
  • [MeSH-major] Barrett Esophagus / surgery. Catheter Ablation / methods
  • [MeSH-minor] Adenocarcinoma / epidemiology. Cost-Benefit Analysis. Esophageal Neoplasms / epidemiology. Humans. Risk Factors

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  • (PMID = 19072339.001).
  • [ISSN] 1747-4132
  • [Journal-full-title] Expert review of gastroenterology & hepatology
  • [ISO-abbreviation] Expert Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Axel J, Weickert U, Dancygier H: [Gastrointestinal tumor (GIST) of the esophagus in a 34-year-old man: clubbed fingers and alopecia arealis as an early paraneoplastic phenomenon]. Dtsch Med Wochenschr; 2005 Oct 21;130(42):2380-3
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  • [Title] [Gastrointestinal tumor (GIST) of the esophagus in a 34-year-old man: clubbed fingers and alopecia arealis as an early paraneoplastic phenomenon].
  • [Transliterated title] Trommelschlegelfinger und Alopecia areata als paraneoplastisches Früh-Phänomen bei Weichteiltumor (GIST) des Osophagus.
  • Over a period of one year clubbing of the fingers had developed and alopecia areata had been noted six months before the diagnosis was established.
  • INVESTIGATIONS AND DIAGNOSIS: Out-patient sonography revealed two large, partly cystic-necrotic space-occupying lesions in the liver.
  • Sonographically guided fine-needle puncture showed cells of a mesenchymal tumor with great cell density and extensive necroses.
  • Gastroscopy and endosonography demonstrated, as a possible primary tumor, a submucosal space-occupying lesion, ca.
  • 3 x 5 cm, in the distal esophagus.
  • TREATMENT AND COURSE: A gastrectomy and resection of the distal esophagus were performed, together with a liver wedge resection.
  • Histopathological examination of the surgical specimen confirmed the diagnosis of leiomyosarcoma.
  • Further immunochemical tests provided the diagnostic criteria of a gastrointestinal stroma tumor (GIST).
  • CONCLUSION: Tumors of the gastrointestinal tract may for a long time produce no or, as in this case, only nonspecific symptoms.
  • An early diagnosis is, however, possible if little known early paraneoplastic phenomena are noted in the clinical examination.
  • [MeSH-major] Alopecia / etiology. Esophageal Neoplasms / ultrasonography. Gastrointestinal Neoplasms / ultrasonography. Osteoarthropathy, Secondary Hypertrophic / etiology

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  • (PMID = 16235145.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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4. Goldberg MF, Levine MS, Torigian DA: Diffuse esophageal spasm: CT findings in seven patients. AJR Am J Roentgenol; 2008 Sep;191(3):758-63
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  • [Title] Diffuse esophageal spasm: CT findings in seven patients.
  • OBJECTIVE: The purpose of this study was to determine the frequency and appearance of esophageal wall thickening on CT scans in a series of patients with findings of diffuse esophageal spasm on barium studies.
  • CONCLUSION: CT revealed marked esophageal wall thickening in seven (21%) of 33 patients who had findings of diffuse esophageal spasm on barium studies.
  • CT showed significantly greater esophageal wall thickening in the lower thoracic esophagus 5 cm above the gastroesophageal junction than in the upper thoracic esophagus at the level of the aortic arch or in the midthoracic esophagus at the level of the carina (p < 0.01).
  • This esophageal wall thickening corresponded to the presence of multiple strong nonperistaltic contractions in the lower thoracic esophagus on barium studies.
  • Our findings suggest that diffuse esophageal spasm should be included in the differential diagnosis when CT shows smooth circumferential wall thickening in the lower half of the thoracic esophagus, particularly in elderly patients with dysphagia or chest pain.
  • [MeSH-major] Barium Sulfate. Esophageal Spasm, Diffuse / radiography. Esophagus / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18716106.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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5. Procházka V, Kala Z, Novotný I, Hrobar P: [Laparoscopic management of an infected oesophageal cyst]. Rozhl Chir; 2005 Nov;84(11):526-8
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  • [Title] [Laparoscopic management of an infected oesophageal cyst].
  • Oesophageal cysts are rare congenital anomalies.
  • Most commonly, they are located in the posterior mediastinum, approximately at the level of the distal third of the oesophagus.
  • A CT or MRI, oesophagoscopy and endosonography of the oesophagus are the essential diagnostic methods.
  • In this report, a case of a potential complication is described: infection of the oesophageal cyst of the distal part of the oesophagus following a transoesophageal punction.
  • The laparoscopic method is feasible and safe even if the oesophageal cysts are infected.
  • A complete resection of the cyst would be complicated due to a possibility of injuring the oesophagus.
  • A significance of the peroperative oesophagoscopy to verify the oesophagus position in an unclear anatomic situation due to inflammatory infiltration, is highlighted.
  • The above decreases the risk of the oesophageal wall lesion.
  • [MeSH-major] Bacterial Infections / complications. Esophageal Cyst / surgery. Laparoscopy

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  • (PMID = 16334930.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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6. Lerut T, Coosemans W, Decker G, De Leyn P, Moons J, Nafteux P, Van Raemdonck D: Diagnosis and therapy in advanced cancer of the esophagus and the gastroesophageal junction. Curr Opin Gastroenterol; 2006 Jul;22(4):437-41
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  • [Title] Diagnosis and therapy in advanced cancer of the esophagus and the gastroesophageal junction.
  • PURPOSE OF REVIEW: The aim of this article is to discuss recent developments in the diagnosis and treatment with curative option of advanced cancer of the esophagus and gastroesophageal junction.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy. Esophagogastric Junction. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy
  • [MeSH-minor] Biopsy, Needle. Combined Modality Therapy / methods. Diagnosis, Differential. Endosonography. Humans. Neoplasm Staging. Positron-Emission Tomography. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 16760764.001).
  • [ISSN] 0267-1379
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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7. Chao HC, Chen SY, Kong MS: Successful treatment of congenital esophageal web by endoscopic electrocauterization and balloon dilatation. J Pediatr Surg; 2008 Jan;43(1):e13-5
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  • [Title] Successful treatment of congenital esophageal web by endoscopic electrocauterization and balloon dilatation.
  • We report a 3-year-old boy who presented with a foreign body impacted in the esophagus and had a poor tolerance of solid food since he was 5 to 6 months old.
  • An esophagoscopy and barium esophagogram revealed an esophageal web in the distal third of the esophagus.
  • Three courses of endoscopic balloon dilatation resulted in transient improvement in his dysphagia and vomiting; a follow-up barium esophagogram and esophagoscopy showed limited improvement of the esophageal stenosis.
  • Two courses of endoscopic electrocauterization and balloon dilatation improved the clinical symptoms and esophageal stenosis.
  • [MeSH-major] Catheterization / methods. Choristoma / diagnosis. Diaphragm. Electrocoagulation / methods. Esophageal Stenosis / congenital. Esophageal Stenosis / therapy

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  • (PMID = 18206438.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Stübgen JP: Facioscapulohumeral muscular dystrophy: a radiologic and manometric study of the pharynx and esophagus. Dysphagia; 2008 Dec;23(4):341-7
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  • [Title] Facioscapulohumeral muscular dystrophy: a radiologic and manometric study of the pharynx and esophagus.
  • The aim of this study was to ascertain by relatively noninvasive techniques whether the dystrophic muscle disease that underlies FSHD involves the pharyngeal and/or the esophageal striated and smooth muscles.
  • We used conventional cineradiography and intraluminal esophageal manometry on separate occasions to study pharyngeal and esophageal function in 20 patients with FSHD at various stages of disease, with or without complaints of deglutition.
  • The mean disease duration was 16.7 years (range = 4-39 years).Five patients admitted to having intermittent oropharyngeal dysphagia (difficulty to initiate swallowing, cough after swallowing, sensation of food stuck in throat, or nasal regurgitation), and three patients admitted to intermittent esophageal dysphagia (difficulty swallowing both liquids and solids).
  • Abnormal instrumental results were documented in eight patients: Cineradiography detected ineffectual pharyngeal contractions (2 patients), pharyngeal diverticula but normal pharyngeal motility (2 patients), and decreased cricopharyngeal and upper esophageal relaxation (2 patients).
  • However, manometry detected motility abnormalities that were not reflected in the mean data and included increased lower esophageal sphincter resting pressure with normal or abnormal relaxation (2 patients) and inconsistent, high-amplitude, long-duration, primary peristaltic contractions (1 patient).
  • This study did not definitely establish that the cause of abnormal pharyngeal and cervical esophageal function was related to the dystrophic process that underlies FSHD.
  • Any esophageal dysmotility was nonspecific and insignificant and was caused by an undetermined, probably neuropathic, process unrelated to the muscular dystrophy.
  • [MeSH-major] Deglutition. Deglutition Disorders / diagnostic imaging. Esophagus / diagnostic imaging. Manometry. Muscular Dystrophy, Facioscapulohumeral / diagnostic imaging. Pharyngeal Diseases / diagnostic imaging. Pharynx / pathology

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  • [Cites] Histopathology. 1979 May;3(3):223-32 [468124.001]
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  • (PMID = 18259705.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Bulynin VV: [Nonstandard variants of an approach to prophylactics and treatment of dysphagia syndrome]. Vestn Khir Im I I Grek; 2008;167(4):105-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The author describes variants of using magnetic anastomoses in treatment of dysphagia after chemical burns of the esophagus.
  • [MeSH-major] Burns, Chemical / therapy. Deglutition Disorders / prevention & control. Dilatation / methods. Esophagus / injuries. Esophagus / surgery. Intestine, Small / surgery

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  • (PMID = 18942450.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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10. Spinoglio G, Summa M, Quarati R, Testa S, Priora F, Lenti ML, Ravazzoni F, Piscioneri D: Thoracoscopic and Laparoscopic Esophagectomy in a Case of Spontaneous Rupture of the Esophagus (Boerhaave's Syndrome). Eur J Trauma Emerg Surg; 2009 Aug;35(4):414-6
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  • [Title] Thoracoscopic and Laparoscopic Esophagectomy in a Case of Spontaneous Rupture of the Esophagus (Boerhaave's Syndrome).
  • Spontaneous barogenic rupture of the esophagus is a rare disease with high morbidity and mortality.
  • Here, we describe a minimal invasive esophagectomy procedure for an esophageal barogenic rupture.
  • This minimal-invasive approach allowed direct optimal visualization of the esophageal laceration and a thorough mediastinal cleansing, thereby avoiding any septic complications, which are the major concern in this particular clinical procedure.

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  • (PMID = 26815060.001).
  • [ISSN] 1863-9933
  • [Journal-full-title] European journal of trauma and emergency surgery : official publication of the European Trauma Society
  • [ISO-abbreviation] Eur J Trauma Emerg Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Abdominal / Thoracic and abdominal
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11. Struijs B, de Bree R, van Groeningen CJ, Mooi WJ, Leemans CR: Tonsillar metastasis of oesophageal adenocarcinoma. Eur Arch Otorhinolaryngol; 2008 Jan;265(1):127-9
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  • [Title] Tonsillar metastasis of oesophageal adenocarcinoma.
  • Tonsillar metastasis of adenocarcinoma of the oesophagus has not been reported previously.
  • We report a case of a 57-year-old male with a primary adenocarcinoma of the distal esophagus with a metastasis in the right palatine tonsil.
  • Metastatic tumour involving the palatine tonsil is rare.
  • Hypothetically the dissemination of tumour cells could be lymphogenic or secondary by transportation due to vomiting or at the time of endoscopy, but most likely represents haematogenous spread.
  • [MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Tonsillar Neoplasms / secondary

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  • (PMID = 17657505.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2099162
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12. Jarmusz K: [Nursing care in patients after thoracosurgical treatment especially esophageal tumor]. Pol Merkur Lekarski; 2009 May;26(155):572-4
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  • [Title] [Nursing care in patients after thoracosurgical treatment especially esophageal tumor].
  • The main target of this study is to create a model of after-surgery nursing care system in patients after thoracic operations, especial patients with lungs and esophagus tumors.
  • Postoperative care in patient after esophagus operations simply means: continuous monitoring of vital signs, pharmacological treatment, parenteral feeding and daily nursing activities.
  • [MeSH-major] Esophageal Neoplasms / nursing. Esophageal Neoplasms / surgery. Lung Neoplasms / nursing. Lung Neoplasms / surgery. Postoperative Care / nursing. Thoracic Surgical Procedures / nursing

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  • (PMID = 19606730.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 12
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13. Ahmadi A, Draganov P: Endoscopic mucosal resection in the upper gastrointestinal tract. World J Gastroenterol; 2008 Apr 7;14(13):1984-9
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  • In the Western world, the predominant indication for EMR in the upper gastrointestinal tract is the staging and treatment of advance dysplasia and early neoplasia in Barrett's esophagus.
  • This review will describe the basis, indications, techniques, and complications of EMR, and its role in the management of Barrett's esophagus.
  • [MeSH-minor] Animals. Barrett Esophagus / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Gastroenterology / methods. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / surgery. Humans. Precancerous Conditions

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  • (PMID = 18395896.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 70
  • [Other-IDs] NLM/ PMC2701517
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14. Lazebnik LB, Masharova AA, Vasnev OS, Bordin DS, Valitova ÉR, Ianova OB: [Gastroesophageal reflux disease in the elderly patients: epidemiology, clinical features, therapy]. Eksp Klin Gastroenterol; 2010;(12):10-6
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  • We studied the course and treatment of elderly patients with GERD and assessed the results of surgical treatment of patients with short esophagus syndrome.
  • METHODS: Was made a prospective study of 500 patients with GERD (241--age 60 years) that were treated with PPI and 95 patients were operated with an axial HH (42 of them with shortening of the esophagus 1-2-th power), mean age 65.7 +/- 17.4 years.
  • We used endoscopic techniques (endoscopy), daily pH monitoring, esophageal manometry.
  • RESULTS: Results of a prospective clinical study in elderly patients allocated two clinical variants of the flow of GERD, predicting a more severe course of disease in patients with a short history (up to 5 years) (the second "adult type") and suggests a differentiated approach to diagnosis and treatment.
  • In this case, patients with ineffective esophageal motility observed improvement in esophageal manometry, indicating that nature reflux of these disorders at baseline.
  • CONCLUSIONS: Course and treatment of GERD in the elderly has its own characteristics, which dictate the need for an integrated approach to diagnosis and treatment of these patients.
  • Older patients with esophageal shortening, 1 st degree possible to perform laparoscopic surgery, and shortening of the esophagus, 2 nd degree is the most secure laparotomic access.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Endoscopy / methods. Esophagus / pathology. Esophagus / physiopathology. Female. Humans. Male. Middle Aged. Prevalence. Prospective Studies. Russia / epidemiology

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  • (PMID = 21560614.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Russia (Federation)
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15. Feagins LA, Souza RF: Molecular targets for treatment of Barrett's esophagus. Dis Esophagus; 2005;18(2):75-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular targets for treatment of Barrett's esophagus.
  • SUMMARY. Esophageal cancer is one of the most deadly forms of gastrointestinal cancer with a mortality rate exceeding 90%.
  • The major risk factors for esophageal adenocarcinoma are gastroesophageal reflux disease (GERD) and its sequela, Barrett's esophagus.
  • In a minority of patients however, ongoing GERD leads to replacement of esophageal squamous mucosa with metaplastic, intestinal-type Barrett's mucosa.
  • In the setting of continued peptic injury, Barrett's mucosa can give rise to esophageal adenocarcinoma.
  • Despite the widespread use of potent acid suppressive therapies for patients with GERD, the incidence of esophageal adenocarcinoma, among white men in the USA, the UK and Europe has continued to rise.
  • Cancers in Barrett's esophagus arise through a sequence of genetic events that endow the cells with six essential physiologic hallmarks of cancer as described by Hanahan and Weinberg in 2000.
  • While the acquisition of these essential attributes is not specific to the neoplastic progression of Barrett's esophagus, this review will focus on the genetic alterations that occur in Barrett's cells that contribute to the acquisition of each of the hallmarks.

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  • (PMID = 16053481.001).
  • [ISSN] 1120-8694
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / 5T32DK-07745; United States / NIDDK NIH HHS / DK / DK63621
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Growth Inhibitors
  • [Number-of-references] 111
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16. Maher MM, Nassar MI: Black esophagus: a case report. Cases J; 2008;1(1):367
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  • [Title] Black esophagus: a case report.
  • The black esophagus is a rare observation during upper endoscopy.
  • We describe a case of a male with chronic obstructive pulmonary disease, hypertension, diabetes, acute renal failure and in septic state, who developed a black esophagus after hypotensive episodes.

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  • (PMID = 19046463.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2613895
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17. Liu W, Hao XS, Fan Q, Li HX, Song LN, Wang SJ, Wang PZ, Jin Y, Chen Y, Guan LY, Ping YM, Meng XL, Wang R, Liu JF, Wang XL: [Cox proportional hazard model analysis of prognosis in patients with carcinoma of esophagus and gastric cardia after radical resection]. Zhonghua Zhong Liu Za Zhi; 2008 Dec;30(12):921-5
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  • [Title] [Cox proportional hazard model analysis of prognosis in patients with carcinoma of esophagus and gastric cardia after radical resection].
  • OBJECTIVE: To investigate the factors affecting the long-term survival of patients with carcinoma of esophagus and gastric cardia after curative resection.
  • METHODS: The clinical data of 906 patients with carcinoma of esophagus and gastric cardia treated by radical resection in 1996 - 2004 were analyzed retrospectively.
  • The univariate analysis showed that age, length of tumor, pathological differentiation, number of metastatic lymph nodes, depth of invasion, involvement of adjacent organs and the TNM stage influenced the prognosis significantly (P < 0.01).
  • CONCLUSION: The independent prognostic factors of the patients with carcinoma of esophagus and gastric cardia are pathologic differentiation, TNM stage, number of metastatic lymph nodes, and involvement of adjacent organs.
  • The other factors influencing survival are age, length of tumor and depth of invasion.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Cardia. Esophageal Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Esophagectomy / methods. Female. Follow-Up Studies. Gastrectomy / methods. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Rate

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  • (PMID = 19173994.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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18. Choueiri NE, Prather CM: Barrett's esophagus: a pre-cancerous condition approach to diagnosis and management. Mo Med; 2009 Sep-Oct;106(5):339-42
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  • [Title] Barrett's esophagus: a pre-cancerous condition approach to diagnosis and management.
  • Barrett's esophagus (BE) results from prolonged uncontrolled gastroesophageal reflux (GERD).
  • High grade dysplasia warrants intervention with ablative techniques or surgery due to the extremely high rate of malignant transformation to esophageal adenocarcinoma.
  • [MeSH-major] Barrett Esophagus / diagnosis. Barrett Esophagus / therapy
  • [MeSH-minor] Aged. Esophageal Neoplasms / etiology. Esophageal Neoplasms / prevention & control. Gastroesophageal Reflux / complications. Gastroesophageal Reflux / surgery. Humans. Male. Risk Factors

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  • (PMID = 19902713.001).
  • [ISSN] 0026-6620
  • [Journal-full-title] Missouri medicine
  • [ISO-abbreviation] Mo Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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19. Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J: Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus. Cochrane Database Syst Rev; 2010;(5):CD007334
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  • [Title] Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus.
  • BACKGROUND: Barrett's oesophagus is one of the most common premalignant lesions in the world.
  • OBJECTIVES: We used data from randomised controlled trials to examine the effectiveness of endotherapies compared with surgery, in people with Barrett's Oesophagus; those with early neoplasias (defined as high grade dysplasia (HGD), and those with early cancer (defined as carcinoma in-situ, superficially invasive, early cancer or superficial cancer T-1m (T1-a) and T-1sm (T1-b)).
  • TYPES OF PARTICIPANTS: patients of any age and either gender with a histologically confirmed diagnosis of early neoplasia (HGD and early cancer) in Barrett's or squamous lined oesophagus.Types of interventions; endotherapies (the intervention) compared with surgery (the control), all with curative intent.
  • [MeSH-major] Barrett Esophagus / surgery. Esophageal Neoplasms / surgery. Esophagoscopy / methods. Precancerous Conditions / surgery

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  • [UpdateIn] Cochrane Database Syst Rev. 2012;11:CD007334 [23152243.001]
  • [UpdateOf] Cochrane Database Syst Rev. 2009;(2):CD007334 [19370683.001]
  • (PMID = 20464752.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 93
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20. Prasad G, Wang KK: Endoscopic Mucosal Resection: Esophageal Applications. Curr Treat Options Gastroenterol; 2005 Feb;8(1):41-49
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  • [Title] Endoscopic Mucosal Resection: Esophageal Applications.
  • Endoscopic mucosal resection is an invaluable tool to diagnose and potentially treat superficial cancers in Barrett's esophagus as well as squamous cell cancers.
  • The tissue retrieved from these procedures gives the endoscopist histologic information regarding tumor depth of penetration, which is critical to treatment of early cancers.
  • Endoscopic mucosal resection can be used to diagnose these lesions with relative safety, particularly when applied to the esophagus.

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  • (PMID = 15625033.001).
  • [ISSN] 1092-8472
  • [Journal-full-title] Current treatment options in gastroenterology
  • [ISO-abbreviation] Curr Treat Options Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Dvorak K, Chavarria M, Payne CM, Ramsey L, Crowley-Weber C, Dvorakova B, Dvorak B, Bernstein H, Holubec H, Sampliner RE, Bernstein C, Prasad A, Green SB, Garewal H: Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus. Clin Cancer Res; 2007 Sep 15;13(18 Pt 1):5305-13
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  • [Title] Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus.
  • OBJECTIVES: The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear.
  • MATERIALS AND METHODS: Immunohistochemistry was used to assess levels of phosphorylated STAT3 in esophageal tissue samples from BE patients with different grades of dysplasia.
  • Seg-1 esophageal adenocarcinoma cells were evaluated for STAT3 activation and IL-6 and Bcl-x(L) expression by molecular biology techniques, including Western blot, reverse transcription-PCR, and ELISA after exposure to control media (pH 7.4), media supplemented with a 0.1 mmol/L bile acid cocktail with media at pH 4 or media at pH 4 with bile acid cocktail.
  • This alteration, if persistent in vivo, may underlie the development of dysplastic BE and tumor progression.
  • [MeSH-major] Barrett Esophagus / metabolism. Bile Acids and Salts / metabolism. Esophagus / metabolism. Interleukin-6 / metabolism. STAT3 Transcription Factor / metabolism
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Apoptosis. Esophageal Neoplasms / chemistry. Esophageal Neoplasms / metabolism. Esophageal Neoplasms / pathology. Female. Gastric Acid / metabolism. Humans. Hydrogen-Ion Concentration. Male. Middle Aged. RNA, Messenger / analysis. RNA, Messenger / metabolism. Tumor Cells, Cultured. bcl-X Protein / genetics. bcl-X Protein / metabolism

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  • (PMID = 17875759.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / IP50 CA95060
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Interleukin-6; 0 / RNA, Messenger; 0 / STAT3 Transcription Factor; 0 / bcl-X Protein
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22. Steevens J, Schouten LJ, Driessen AL, Huysentruyt CJ, Keulemans YC, Goldbohm RA, van den Brandt PA: Toenail selenium status and the risk of Barrett's esophagus: the Netherlands Cohort Study. Cancer Causes Control; 2010 Dec;21(12):2259-68
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  • [Title] Toenail selenium status and the risk of Barrett's esophagus: the Netherlands Cohort Study.
  • OBJECTIVE: To investigate the association between selenium and the risk of Barrett's esophagus (BE), the precursor lesion of esophageal adenocarcinoma.
  • [MeSH-major] Barrett Esophagus / etiology. Nails / chemistry. Selenium / analysis

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  • (PMID = 20936529.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] H6241UJ22B / Selenium
  • [Other-IDs] NLM/ PMC3006659
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23. Lao-Sirieix P, Corovic A, Jankowski J, Lowe A, Triadafilopoulos G, Fitzgerald RC: Physiological and molecular analysis of acid loading mechanisms in squamous and columnar-lined esophagus. Dis Esophagus; 2008;21(6):529-38
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  • [Title] Physiological and molecular analysis of acid loading mechanisms in squamous and columnar-lined esophagus.
  • SUMMARY: Barrett's esophagus (BE) may be an adaptive cellular response to repeated acid exposure.
  • The aims of this study were to compare intracellular acid loading in BE cells with normal squamous esophageal cells.
  • Barrett's adenocarcinoma cell lines TE7 and OE-33 were compared with a normal esophageal (NE) cell line OE-21.
  • [MeSH-major] Barrett Esophagus / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Esophageal pH Monitoring. Gastroesophageal Reflux / physiopathology
  • [MeSH-minor] Biopsy, Needle. Cell Division. Female. Humans. Male. Molecular Biology. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction. Sampling Studies. Sensitivity and Specificity. Tissue Culture Techniques

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  • (PMID = 18840137.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105365007; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm
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24. Raab M, Neuhuber WL: Number and distribution of intraganglionic laminar endings in the mouse esophagus as demonstrated with two different immunohistochemical markers. J Histochem Cytochem; 2005 Aug;53(8):1023-31
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  • [Title] Number and distribution of intraganglionic laminar endings in the mouse esophagus as demonstrated with two different immunohistochemical markers.
  • Intraganglionic laminar endings (IGLEs) represent the only vagal mechanosensory terminals in the tunica muscularis of the esophagus.
  • We counted IGLEs immunostained for VGLUT2 and P2 x 2, respectively, and mapped their distribution in esophageal wholemounts of C57Bl/6 mice.
  • Whereas the distribution of VGLUT2-immunopositive IGLEs closely matched that of myenteric ganglia, P2 x 2-immunopositive IGLEs were rarely found in upper and middle esophagus but increasingly in its lower parts.
  • Thus, VGLUT2 and P2 x 2 represent two specific markers for qualitative demonstration of esophageal IGLEs.
  • However, VGLUT2 may be superior to P2 x 2 as a quantitative marker for IGLEs in the esophagus of C57Bl/6 mice.
  • [MeSH-major] Esophagus / innervation. Ganglia, Autonomic / ultrastructure. Muscle, Smooth / innervation. Nerve Endings / ultrastructure. Vagus Nerve / ultrastructure

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  • (PMID = 15923367.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Coloring Agents; 0 / Indoles; 0 / Membrane Transport Proteins; 0 / Organometallic Compounds; 0 / Receptors, Purinergic P2; 0 / Slc17a6 protein, mouse; 0 / Vesicular Glutamate Transport Protein 2; 3VEX9T7UT5 / copper phthalocyanine
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25. Schauer M, Janssen KP, Rimkus C, Raggi M, Feith M, Friess H, Theisen J: Microarray-based response prediction in esophageal adenocarcinoma. Clin Cancer Res; 2010 Jan 1;16(1):330-7
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  • [Title] Microarray-based response prediction in esophageal adenocarcinoma.
  • PURPOSE: In locally advanced (uT(3), N(+)) adenocarcinomas of the esophagus, neoadjuvant chemotherapy improves patient outcome.
  • Therefore, in the present study, we evaluated whether the response to neoadjuvant chemotherapy can be predicted by a pretreatment tumor biopsy analysis.
  • EXPERIMENTAL DESIGN: Biopsies of 47 patients with locally advanced (uT(3), N(+)) adenocarcinoma of the esophagus were obtained during primary staging.
  • All patients underwent neoadjuvant chemotherapy with cisplatin, 5-fluorouracil, and leucovorin and subsequent resection of the esophagus.
  • The predominance of tumor cells within the specimens was >70%.
  • RESULTS: A total of 86 genes were at least 2-fold differentially regulated comparing responding with nonresponding adenocarcinomas of the esophagus.
  • CONCLUSIONS: There were significant differences in the gene profile between patients with adenocarcinoma of the esophagus responding to neoadjuvant chemotherapy compared with nonresponding patients.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / genetics. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / genetics. Neoadjuvant Therapy. Tissue Array Analysis
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Gene Expression Profiling. Humans. Male. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 20028767.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Fan YH, Lü B, Zhan LX, Zhang L: [Oesophageal acid exposure test in non-erosive gastroesophageal reflux disease and the diagnostic value of rabeprazole]. Zhonghua Nei Ke Za Zhi; 2007 Jun;46(6):475-7
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  • [Title] [Oesophageal acid exposure test in non-erosive gastroesophageal reflux disease and the diagnostic value of rabeprazole].
  • OBJECTIVE: To study the acid exposure characteristic of the subtypes of non-erosive gastroesophageal reflux disease (NERD) and discuss the value of rabeprazole in its diagnosis.
  • METHODS: 32 cases of the NERD were subdivided into three groups--14 cases with abnormal acid reflux, 11 with acid hypersensitive oesophagus and the remaining 7 with functional heartburn.
  • (1) Acid exposure in each group: In the abnormal acid reflux group, the total degree of acid reflux, the degree of long reflux, the time of pH < 4 and the time percentage of pH < 4 were obviously increased as compared with the groups of acid hypersensitive oesophagus and functional heartburn; the symptom index of the group with acid hypersensitive oesophagus was apparently higher than that of the group of functional heartburn [(81.0 +/- 22.5)% vs (8.6 +/- 14.8)%, P < 0.01]. (2) Comparison of symptoms: There was no obvious difference in the score of typical symptoms and total score of symptoms before therapy among the groups; the score extraesophageal symptoms in the acid hypersensitive oesophagus group was much higher than that in the abnormal acid reflux group (4.0 +/- 3.8 vs 0.9 +/- 2.2, P < 0.05). (3) The curative effect: The score of oesophageal symptoms and the total score of symptoms in the abnormal acid reflux and the acid hypersensitive oesophagus groups after treatment with rabeprazole for 1 and 2 weeks showed obvious decrease, while in the functional heartburn group the scores showed only a declining trend, but with no statistical significance, and there was obvious distinction of the total score of symptoms in the abnormal acid reflux group as compared with the other two groups after 2 weeks of therapy. (4) The total effective rate was 56.3% and 68.8% after 1 week and 2 weeks of therapy.
  • Rabeprazole test showed that the sensitivity and specificity for abnormal acid reflux and acid hypersensitive oesophagus were 64.0% and 71.4% after 1 week and 80.0% and 71.4% after 2 weeks of therapy. CONCLUSIONS:.
  • (1) The main manifestations shown by the acid exposure of abnormal acid reflux are the increase of total degree of acid reflux, the degree of long reflux and the time of pH < 4. (2) The patients with hypersensitive oesophagus may be much more likely to suffer from extraesophageal symptoms. (3) Rabeprazole diagnosis test is valuable in the diagnosis and subdivision of non-erosive gastroesophageal reflux disease.
  • [MeSH-major] 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use. Esophagus / chemistry. Gastroesophageal Reflux / drug therapy

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  • (PMID = 17663823.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Ulcer Agents; 32828355LL / Rabeprazole
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27. Groves C, Jankowski J, Barker F, Holdstock G: A family history of Barrett's oesophagus: another risk factor? Scand J Gastroenterol; 2005 Sep;40(9):1127-8
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  • [Title] A family history of Barrett's oesophagus: another risk factor?
  • Barrett's oesophagus and oesophageal adenocarcinoma, although increasingly common, have no known genetic cause.
  • In this report we describe a family with a remarkable history of Barrett's oesophagus and adenocarcinoma.
  • The index case is a 76-year-old man with adenocarcinoma arising within Barrett's oesophagus.
  • Two of his three brothers, aged 68 and 78 years, also developed adenocarcinoma arising in Barrett's oesophagus and the remaining 67-year-old brother has severe dysplasia in biopsies from Barrett's oesophagus.
  • The sons and daughters of the index case requested screening and all had histologically confirmed short-segment Barrett's oesophagus.
  • This kindred appears to be genetically susceptible to Barrett's oesophagus and oesophageal adenocarcinoma.
  • [MeSH-major] Barrett Esophagus / genetics. Pedigree
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Aged. Biopsy. Esophageal Neoplasms / genetics. Esophageal Neoplasms / pathology. Genetic Linkage. Genetic Predisposition to Disease. Humans. Male. Risk Factors. Siblings

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  • (PMID = 16211720.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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28. Pruyt M, Devriendt D, Vanneste A: Malignant melanoma and adenocarcinoma of a Barrett oesophagus. Acta Chir Belg; 2006 Sep-Oct;106(5):616-8
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  • [Title] Malignant melanoma and adenocarcinoma of a Barrett oesophagus.
  • An adenocarcinoma with a malignant melanoma in a Barrett oesophagus is extremely rare.
  • The diagnosis of a malignant melanoma can be difficult but can be made by tissue examination with a special immunoreaction with several markers to see it expresses S-100, but lacks activity for KER and EMA.
  • [MeSH-major] Adenocarcinoma / complications. Barrett Esophagus / complications. Esophageal Neoplasms / complications. Melanoma / complications. Neoplasms, Multiple Primary / complications
  • [MeSH-minor] Antigens, Neoplasm. Humans. Immunohistochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis

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  • (PMID = 17168284.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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29. Sam AD Jr, Chaer RA, Cintron J, Teresi M, Massad MG: Upper gastrointestinal bleeding caused by a "hypophrenic" diverticulum of the distal esophagus. Am Surg; 2005 Apr;71(4):333-5
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  • [Title] Upper gastrointestinal bleeding caused by a "hypophrenic" diverticulum of the distal esophagus.
  • Distal esophageal diverticula are uncommon acquired anomalies of the distal thoracic esophagus.
  • We report a case of an elderly man presenting with a history of upper gastrointestinal bleeding secondary to a distal esophageal diverticulum arising from the intra-abdominal portion of the esophagus.
  • To our knowledge, this is the first report of upper gastrointestinal bleeding from a subdiaphragmatic esophageal diverticulum.
  • We propose the term "hypophrenic diverticulum of the esophagus" for this disease entity, and we would like to bring it to the attention of readers of The American Surgeon.
  • [MeSH-major] Diverticulum, Esophageal / complications. Gastrointestinal Hemorrhage / etiology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Endoscopy, Digestive System. Follow-Up Studies. Humans. Male. Phrenic Nerve. Radiography, Abdominal. Reconstructive Surgical Procedures / methods

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  • (PMID = 15943409.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Tatsuta T, Mukaisho K, Sugihara H, Miwa K, Tani T, Hattori T: Expression of Cdx2 in early GRCL of Barrett's esophagus induced in rats by duodenal reflux. Dig Dis Sci; 2005 Mar;50(3):425-31
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  • [Title] Expression of Cdx2 in early GRCL of Barrett's esophagus induced in rats by duodenal reflux.
  • We studied the role of Cdx2 in the development of Barrett's esophagus (BE).
  • BE very likely develops through the GRCL, and we studied the expression of Cdx2 in various lesions of rat esophageal mucosa induced by duodenal reflux, using reverse transciptase-polymerase chain reaction and immunohistochemistry against Cdx2.
  • [MeSH-major] Barrett Esophagus / genetics. Barrett Esophagus / pathology. Cell Transformation, Neoplastic / pathology. Duodenogastric Reflux / physiopathology. Homeodomain Proteins / genetics. Trans-Activators / genetics

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  • (PMID = 15810620.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / Homeodomain Proteins; 0 / Trans-Activators
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31. Spechler SJ, Sharma P, Traxler B, Levine D, Falk GW: Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial. Am J Gastroenterol; 2006 Sep;101(9):1964-71
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  • [Title] Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial.
  • BACKGROUND: It has been suggested that patients with Barrett's esophagus (BE) are unusually resistant to the antisecretory effects of proton pump inhibitors (PPIs).
  • Intraesophageal pH was <4.0 for mean values of <5% of the monitoring period with all the three dosing regimens, but esophageal pH remained <4.0 for >5% of the time in 16%, 23%, and 19% of patients receiving esomeprazole 40 mg t.i.d., 40 mg b.i.d., and 20 mg t.i.d., respectively.
  • CONCLUSIONS: All the three esomeprazole dosages significantly decreased intragastric acidity and reduced esophageal acid exposure to mean normal values in the total group of patients with BE.
  • However, abnormal esophageal acid exposure continued in 16-23% of patients despite the significant decrease in gastric acidity.
  • [MeSH-major] Barrett Esophagus / metabolism. Enzyme Inhibitors / administration & dosage. Esomeprazole / administration & dosage. Esophageal pH Monitoring. Gastric Acid / metabolism

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  • (PMID = 16848802.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; N3PA6559FT / Esomeprazole
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32. Engel MA, Raithel M, Amann K, Greess H, Hahn EG, Konturek PC: Rare coincidence of eosinophilic esophagitis with esophageal stenosis and intramural pseudodiverticulosis. Dig Liver Dis; 2008 Aug;40(8):700-6
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  • [Title] Rare coincidence of eosinophilic esophagitis with esophageal stenosis and intramural pseudodiverticulosis.
  • We describe the first detailed case of eosinophilic esophagitis associated with esophageal intramural pseudodiverticulosis and gastro-esophageal reflux disease in a 24-year-old man, who suffered from recurrent dysphagia since the age of 3 years.
  • An esophagogram revealed a high-grade stenosis in the proximal part of the esophagus.
  • Histological evaluation of esophageal mucosal biopsies demonstrated more than 20 eosinophil granulocytes per high power field, indicative of eosinophilic esophagitis.
  • Additionally, esophago-gastro-duodenoscopy showed pseudodiverticulosis in the distal portion of the esophagus.
  • [MeSH-major] Deglutition Disorders / etiology. Diverticulum, Esophageal / complications. Eosinophilia / complications. Esophageal Stenosis / complications. Esophagitis / complications

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  • (PMID = 17643358.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Androstadienes; 0 / Anti-Allergic Agents; CUT2W21N7U / Fluticasone
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33. Wagner TD, Khushalani N, Yang GY: Clinical T2N0M0 carcinoma of thoracic esophagus. J Thorac Dis; 2010 Mar;2(1):36-42
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  • [Title] Clinical T2N0M0 carcinoma of thoracic esophagus.
  • The incidence of esophageal cancer continues to rise.
  • However, with screening programs, like those in place for patients with Barrett's esophagus, many patients are being diagnosed earlier in their disease course.
  • Results of randomized trials and meta-analyses have led to emerging guidelines advocating for neoadjuvant therapy as part of the treatment algorithm for esophageal cancer, particularly for T3 or greater T-stage and/or node-positive disease.
  • And for those patients that present with disease localized to the esophageal mucosa, endoscopic mucosal resection has proved to be an effective and less morbid alternative to radical resection.
  • In this manuscript, recent data regarding work-up and treatment are reviewed along with a closer look at those patients clinically staged with T2N0M0 (Stage IIA) esophageal cancer.

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  • (PMID = 22263015.001).
  • [ISSN] 2077-6624
  • [Journal-full-title] Journal of thoracic disease
  • [ISO-abbreviation] J Thorac Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3256438
  • [Keywords] NOTNLM ; T2 esophageal cancer / chemotherapy trimodality therapy / endoscopic ultrasound / esophagectomy / radiation therapy
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34. Schlöbe D, Hölzle D, Hatz D, von Meyer L, Tricker AR, Richter E: 4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victims. Toxicology; 2008 Mar 12;245(1-2):154-61
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  • [Title] 4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victims.
  • 4-Hydroxy-l-(3-pyridyl)-l-butanone (HPB)-releasing adducts are formed by metabolic activation of N'-nitrosonornicotine and 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone and have been proposed as specific biomarkers for exposure to tobacco smoke.
  • In the present study we extended the determination of HPB-releasing DNA adducts by gas chromatography-negative ion chemical ionization-mass spectrometry (GC-NICI-MS) to samples of peripheral lung, lower esophagus and cardia from tumor-free sudden death victims (primarily road traffic accidents, suicide and sudden cardiac arrest).
  • Contrary to our expectation, DNA adduct levels (fmol HPB/mg DNA) in lung tissue from tumor-free smokers (N=32, 92+/-148) were not significantly different from values in nonsmokers (N=56, 61+/-66).
  • The values in tumor-free smokers were on average more than fourfold lower compared to smoking lung cancer patients in our previous study.
  • Adduct levels in the mucosa of esophagus (N=82; 133+/-160) and cardia (N=30; 108+/-102) of sudden death victims did not show any difference according to the current smoking status.
  • HPB-releasing DNA adduct levels in cardia and esophagus were significantly correlated (N=29; Spearman r=0.609; p<0.001).
  • In contrast, adduct levels in lung did not correlate with either esophagus (77 cases) or cardia (28 cases).
  • [MeSH-major] Butanones / analysis. Cardia / metabolism. DNA Adducts / analysis. Death, Sudden. Esophagus / metabolism. Lung / metabolism. Pyridines / analysis

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  • (PMID = 18243467.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / 4-hydroxy-1-(3-pyridyl)-1-butanone; 0 / Biomarkers; 0 / Butanones; 0 / DNA Adducts; 0 / Pyridines; K5161X06LL / Cotinine
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35. Gurvits GE: Black esophagus: acute esophageal necrosis syndrome. World J Gastroenterol; 2010 Jul 14;16(26):3219-25
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  • [Title] Black esophagus: acute esophageal necrosis syndrome.
  • Acute esophageal necrosis (AEN), commonly referred to as "black esophagus", is a rare clinical entity arising from a combination of ischemic insult seen in hemodynamic compromise and low-flow states, corrosive injury from gastric contents in the setting of esophago-gastroparesis and gastric outlet obstruction, and decreased function of mucosal barrier systems and reparative mechanisms present in malnourished and debilitated physical states.
  • The hallmark of this syndrome is the development of diffuse circumferential black mucosal discoloration in the distal esophagus that may extend proximally to involve variable length of the organ.
  • Classic "black esophagus" abruptly stops at the gastroesophageal junction.
  • Biopsy is recommended but not required for the diagnosis.
  • Histologically, necrotic debris, absence of viable squamous epithelium, and necrosis of esophageal mucosa, with possible involvement of submucosa and muscularis propria, are present.
  • Complications include perforation with mediastinal infection/abscess, esophageal stricture and stenosis, superinfection, and death.
  • [MeSH-major] Esophageal Diseases / pathology. Esophagus / pathology
  • [MeSH-minor] Acute Disease. Diagnosis, Differential. Gastric Outlet Obstruction / pathology. Humans. Ischemia / pathology. Necrosis. Prognosis. Syndrome

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  • (PMID = 20614476.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial; Review
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2900712
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36. Teraishi F, Fujiwara T, Jikuhara A, Kamitani S, Morino Y, Sato K, Tanaka N: Esophageal intramural pseudodiverticulosis with esophageal strictures successfully treated with dilation therapy. Ann Thorac Surg; 2006 Sep;82(3):1119-21
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  • [Title] Esophageal intramural pseudodiverticulosis with esophageal strictures successfully treated with dilation therapy.
  • We report a rare case of esophageal intramural pseudodiverticulosis with esophageal strictures.
  • Barium esophagogram demonstrated multiple flask-shaped diverticula out of the esophageal wall with comprehensive luminal stenosis involving the proximal 8 cm and distal 4 cm of the esophagus.
  • Chest computed tomographic scan demonstrated round wall thickening and several intramural gas collections of the proximal esophagus.
  • Dysphagia improved dramatically with esophageal dilation.
  • [MeSH-major] Candidiasis / complications. Catheterization. Diverticulosis, Esophageal / diagnosis. Esophageal Stenosis / diagnosis. Esophagitis / complications. Esophagoscopy
  • [MeSH-minor] Aged. Antifungal Agents / therapeutic use. Chronic Disease. Deglutition Disorders / etiology. Diagnosis, Differential. Fibrosis. Gastroesophageal Reflux / complications. Humans. Male. Omeprazole / therapeutic use. Proton Pump Inhibitors. Tomography, X-Ray Computed

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  • (PMID = 16928560.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Proton Pump Inhibitors; KG60484QX9 / Omeprazole
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37. Goyal MM, Kalwar AK, Vyas RK, Bhati A: A study of serum zinc, selenium and copper levels in carcinoma of esophagus patients. Indian J Clin Biochem; 2006 Mar;21(1):208-10
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  • [Title] A study of serum zinc, selenium and copper levels in carcinoma of esophagus patients.
  • This study was conducted to see the serum level of these three trace elements in cancer esophagus patients.
  • Biopsy confirmed cancer esophagus, 24 patients (12 males, 12 females, mean age 54.5±11.65 year with 23 healthy subjects (16 males, 7 females, mean age 44 ±13.82 years) were included in this study.
  • Serum zinc and copper level were estimated using standard absorption spectrometer technique and serum selenium by Hydride generation method.We observed significant low serum levels of zinc and selenium while high level of serum copper in carcinoma esophagus patients, as compared with normal healthy controls.
  • This shows an association of serum selenium zinc and copper with cancer esophagus.

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  • (PMID = 23105603.001).
  • [ISSN] 0970-1915
  • [Journal-full-title] Indian journal of clinical biochemistry : IJCB
  • [ISO-abbreviation] Indian J Clin Biochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453786
  • [Keywords] NOTNLM ; A.A.S. / Atomic absorption spectrophotometer / Cancer esophagus / Copper and Selenium / Hydride generation / Serum Zinc
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38. Korolev MP, Fedotov LE, Makarova OL: [Treatment of patients with combined burn strictures of the esophagus and stomach]. Vestn Khir Im I I Grek; 2005;164(2):70-2
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  • [Title] [Treatment of patients with combined burn strictures of the esophagus and stomach].
  • The algorithm of examinations and treatment depending on the character of the injury of the esophagus and stomach is described.
  • [MeSH-major] Burns / complications. Constriction, Pathologic / etiology. Constriction, Pathologic / surgery. Digestive System Surgical Procedures / methods. Esophageal Stenosis / etiology. Esophageal Stenosis / surgery. Stomach Diseases / etiology. Stomach Diseases / surgery

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  • (PMID = 16082841.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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39. Bibliography. Current world literature. Esophagus. Curr Opin Gastroenterol; 2007 Jul;23(4):479-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bibliography. Current world literature. Esophagus.
  • [MeSH-major] Esophageal Diseases

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  • (PMID = 17545787.001).
  • [ISSN] 0267-1379
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Bibliography
  • [Publication-country] United States
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40. Kumaravel A, Lopez R, Brainard J, Falk GW: Brush cytology vs. endoscopic biopsy for the surveillance of Barrett's esophagus. Endoscopy; 2010 Oct;42(10):800-5
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  • [Title] Brush cytology vs. endoscopic biopsy for the surveillance of Barrett's esophagus.
  • BACKGROUND AND STUDY AIMS: Periodic surveillance with systematic biopsies is recommended for patients with Barrett's esophagus.
  • The aim of the current study was to determine whether brush cytology provides any additional value over endoscopic surveillance biopsies in patients with Barrett's esophagus.
  • PATIENTS: This retrospective cohort study included 530 patients with Barrett's esophagus undergoing endoscopic surveillance with paired biopsy and cytology specimens at the Cleveland Clinic between January 1994 and July 2008.
  • However, histology had a higher dysplasia detection rate and therefore the value of routine cytology in the surveillance of Barrett's esophagus is questionable.
  • [MeSH-major] Adenocarcinoma / pathology. Barrett Esophagus / pathology. Biopsy / methods. Cytodiagnosis / methods. Esophageal Neoplasms / pathology. Precancerous Conditions / pathology

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • [CommentIn] Endoscopy. 2010 Oct;42(10):864-5 [20886406.001]
  • (PMID = 20821361.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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41. Kim TS, Song SY, Han J, Shim YM, Jeong HS: Giant fibrovascular polyp of the esophagus: CT findings. Abdom Imaging; 2005 Nov-Dec;30(6):653-5
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  • [Title] Giant fibrovascular polyp of the esophagus: CT findings.
  • Giant fibrovascular polyp of the esophagus is a rare intraluminal benign tumor that is covered with normal esophageal mucosa, which consists of fibrous tissue, adipose tissue, and vascular structures.
  • We report a case of a giant fibrovascular polyp of the esophagus in which feeding vessels were well visualized within the stalk of the mass at contrast-enhanced helical computed tomography.
  • [MeSH-major] Esophageal Neoplasms / radiography. Polyps / radiography. Tomography, X-Ray Computed

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  • (PMID = 16132431.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Chang Y, Liu B, Liu GS, Wang T, Gong J: Short-segment Barrett's esophagus and cardia intestinal metaplasia: A comparative analysis. World J Gastroenterol; 2010 Dec 28;16(48):6151-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Short-segment Barrett's esophagus and cardia intestinal metaplasia: A comparative analysis.
  • AIM: to investigate the endoscopy and histology of short-segment Barrett's esophagus (SSBE) and cardia intestinal metaplasia (CIM), and their correlation with Helicobacter pylori (H. pylori) gastritis and gastroesophageal reflux disease (GERD).
  • Eight biopsy specimens from the lower esophagus, cardia, and gastric antrum were stained with hematoxylin/eosin, Alcian blue/periodic acid-Schiff, Alcian blue/high iron diamine and Gimenez dye.
  • [MeSH-major] Barrett Esophagus / pathology. Cardia / pathology. Intestines / pathology. Metaplasia / pathology

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  • (PMID = 21182233.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3012569
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43. Mitas M, Almeida JS, Mikhitarian K, Gillanders WE, Lewin DN, Spyropoulos DD, Hoover L, Graham A, Glenn T, King P, Cole DJ, Hawes R, Reed CE, Hoffman BJ: Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR. Clin Cancer Res; 2005 Mar 15;11(6):2205-14
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  • [Title] Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR.
  • Esophageal adenocarcinoma (EA) is increasing faster than any other cancer in the U.S.
  • In this report, we first show that EA can be distinguished from normal esophagus (NE) and esophageal squamous cell carcinoma by plotting expression values for EpCam, TFF1, and SBEM in three-dimensional Euclidean space.
  • For monitoring progression of Barrett's esophagus (BE) to EA, we developed a highly sensitive assay for limited quantities of tissue whereby 50 ng of RNA are first converted to cDNA using 16 gene-specific primers.
  • [MeSH-major] Adenocarcinoma / diagnosis. Barrett Esophagus / diagnosis. Biomarkers, Tumor / genetics. Esophageal Neoplasms / diagnosis. Gene Expression Regulation, Neoplastic


44. Tutuian R, Agrawal A, Mainie I, Freeman J, Castell DO: Disposable balloon-based oesophageal motility catheters: comparison with solid-state transducers. Neurogastroenterol Motil; 2005 Jun;17(3):453-7
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  • [Title] Disposable balloon-based oesophageal motility catheters: comparison with solid-state transducers.
  • BACKGROUND: Current oesophageal manometry systems use either water-perfused or solid-state pressure transducers.
  • Recently developed single-use disposable catheters use small balloons prefilled with air that transmit the pressure of oesophageal contractions to external transducers.
  • METHODS: Healthy volunteers, patients with ineffective oesophageal motility and nutcracker oesophagus were studied to include a broad range of pressures.
  • A single-use disposable Clinical Innovations (CI) catheter was placed adjacent to a solid-state Konigsberg Instruments (KI) catheter with pressure transducers at 5, 10, 15 and 20 cm above the lower oesophageal sphincter (LOS).
  • Healthy volunteers received additional sets of swallows while having only one catheter in the oesophagus.
  • RESULTS: When both catheters were present in the oesophagus, no differences were noted between mean pressure measurements in the distal oesophagus and there was good correlation between pressures recorded in response to individual swallows.
  • When present alone in the oesophagus the CI catheter recorded lower mean pressures compared with the KI catheter.
  • CONCLUSION: Single-use oesophageal manometry catheters are promising alternatives to solid-state manometry systems in measuring intra-oesophageal pressures.
  • [MeSH-major] Catheterization / instrumentation. Esophageal Motility Disorders / diagnosis. Esophagus / physiology

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  • (PMID = 15916633.001).
  • [ISSN] 1350-1925
  • [Journal-full-title] Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • [ISO-abbreviation] Neurogastroenterol. Motil.
  • [Language] eng
  • [Publication-type] Clinical Conference; Comparative Study; Journal Article
  • [Publication-country] England
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45. Scandrett B, Parker S, Forbes L, Gajadhar A, Dekumyoy P, Waikagul J, Haines D: Distribution of Taenia saginata cysticerci in tissues of experimentally infected cattle. Vet Parasitol; 2009 Oct 14;164(2-4):223-31
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  • These consisted of the traditionally inspected tissue sites of heart, masseter and pterygoid muscles, tongue, oesophagus, and diaphragm (membranous and crura); as well as non-traditional sites of lung, liver and an additional 20 individual muscles or muscle groups.
  • The traditional site of oesophagus was one of the least rewarding of all sites for detection of cysticerci.
  • [MeSH-minor] Animals. Cattle. Esophagus / parasitology. Female. Heart / parasitology. Liver / parasitology. Lung / parasitology. Male. Muscle, Skeletal / parasitology. Tongue / parasitology

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  • (PMID = 19524368.001).
  • [ISSN] 1873-2550
  • [Journal-full-title] Veterinary parasitology
  • [ISO-abbreviation] Vet. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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46. Konturek PC, Burnat G, Rau T, Hahn EG, Konturek S: Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line. Dig Dis Sci; 2008 Mar;53(3):597-605
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  • (1) to compare the expression of adiponectin and ghrelin receptors in Barrett's esophagus and in normal squamous epithelium;.
  • METHODS: The expression of ghrelin and adiponectin receptors (GHS-R1a, Adipo-R1, Adipo R-2) in biopsies from Barrett's esophagus and in Barrett's adenocarcinoma cell line OE-19 was assessed by quantitative RT-PCR (qRT-PCR).
  • [MeSH-major] Adenocarcinoma / metabolism. Apoptosis / physiology. Barrett Esophagus / metabolism. Esophageal Neoplasms / metabolism. Receptors, Adiponectin / metabolism. Receptors, Ghrelin / metabolism
  • [MeSH-minor] Adiponectin / metabolism. Cell Line, Tumor. Culture Media. Cyclooxygenase 2 / metabolism. Deoxycholic Acid. Epithelium / metabolism. Ghrelin / metabolism. Humans. Hydrogen-Ion Concentration. Interleukin-1beta / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17763959.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Culture Media; 0 / Ghrelin; 0 / Interleukin-1beta; 0 / Receptors, Adiponectin; 0 / Receptors, Ghrelin; 0 / Tumor Necrosis Factor-alpha; 005990WHZZ / Deoxycholic Acid; EC 1.14.99.1 / Cyclooxygenase 2
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47. Wallace MB, Sharma P, Lightdale C, Wolfsen H, Coron E, Buchner A, Bajbouj M, Bansal A, Rastogi A, Abrams J, Crook JE, Meining A: Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy. Gastrointest Endosc; 2010 Jul;72(1):19-24
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  • [Title] Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy.
  • OBJECTIVE: To determine the preliminary evaluation accuracy and interobserver agreement of probe-based CLE (pCLE) in Barrett's esophagus (BE).
  • PATIENTS: This study involved nonconsecutive patients undergoing BE surveillance or evaluation of high-grade intraepithelial neoplasia or early adenocarcinoma.
  • MAIN OUTCOME MEASUREMENTS: Sensitivity, specificity, and agreement for the pCLE diagnosis of high-grade intraepithelial neoplasia or carcinoma.
  • RESULTS: In the validation set (n = 20), 11 cases had high-grade intraepithelial neoplasia or invasive carcinoma.
  • The sensitivity for the diagnosis of neoplasia for the 11 endoscopists was 88% (range 6 of 11 to 11 of 11), and the specificity was 96% (range 7 of 9 to 9 of 9).
  • There was substantial agreement on the pCLE diagnosis (86%, kappa 0.72; 95% confidence interval, 0.58-0.86).
  • CONCLUSION: Results suggest that pCLE for the diagnosis of neoplasia in BE has very high accuracy and reliability.

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20381042.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA132892-04; United States / NCI NIH HHS / CA / K07 CA132892; United States / NCI NIH HHS / CA / K07 CA132892-04
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS307179; NLM/ PMC3144146
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48. Wang TD, Triadafilopoulos G, Crawford JM, Dixon LR, Bhandari T, Sahbaie P, Friedland S, Soetikno R, Contag CH: Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy. Proc Natl Acad Sci U S A; 2007 Oct 2;104(40):15864-9
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  • [Title] Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy.
  • Here, spectra were collected from 98 excised specimens of the distal esophagus, including 38 squamous, 38 intestinal metaplasia (Barrett's), and 22 gastric, obtained endoscopically from 32 patients.

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  • (PMID = 17901200.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK067618; United States / NIDDK NIH HHS / DK / R01 DK063624; United States / NCI NIH HHS / CA / U54 CA105296; United States / NIDDK NIH HHS / DK / K08 DK67618
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2000401
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49. van der Zee DC, Vieirra-Travassos D, Kramer WL, Tytgat SH: Thoracoscopic elongation of the esophagus in long gap esophageal atresia. J Pediatr Surg; 2007 Oct;42(10):1785-8
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  • [Title] Thoracoscopic elongation of the esophagus in long gap esophageal atresia.
  • Long gap esophageal atresia in which a primary anastomosis cannot be achieved remains a challenge.
  • Elongation of the esophagus by traction on the 2 ends has been previously described.
  • With the advent of thoracoscopic repair of esophageal atresia, there have thus far been no reports of thoracoscopic repair of long gap esophageal atresia.
  • This paper describes the first successful repair of long gap esophageal atresia by thoracoscopic traction of the 2 esophageal ends and delayed thoracoscopic anastomosis.
  • [MeSH-major] Esophageal Atresia / surgery. Esophagoplasty / methods. Infant, Premature, Diseases / surgery. Thoracoscopy

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  • (PMID = 17923217.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ: A cost-utility analysis of ablative therapy for Barrett's esophagus. Gastroenterology; 2009 Jun;136(7):2101-2114.e1-6
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  • [Title] A cost-utility analysis of ablative therapy for Barrett's esophagus.
  • BACKGROUND & AIMS: Recommendations for patients with Barrett's esophagus (BE) include endoscopic surveillance with esophagectomy for early-stage cancer, although new technologies to ablate dysplasia and metaplasia are available.

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  • (PMID = 19272389.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK080941; United States / NCI NIH HHS / CA / CA106773-03; United States / NCI NIH HHS / CA / R01 CA106773; United States / NIDDK NIH HHS / DK / DK080941-01; United States / NIDDK NIH HHS / DK / K24 DK080941-01; United States / NCI NIH HHS / CA / R01 CA106773-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 110
  • [Other-IDs] NLM/ NIHMS100603; NLM/ PMC2693449
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51. Greenwald BD, Dumot JA, Abrams JA, Lightdale CJ, David DS, Nishioka NS, Yachimski P, Johnston MH, Shaheen NJ, Zfass AM, Smith JO, Gill KR, Burdick JS, Mallat D, Wolfsen HC: Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy. Gastrointest Endosc; 2010 Apr;71(4):686-93
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  • [Title] Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy.
  • BACKGROUND: Few options exist for patients with localized esophageal cancer ineligible for conventional therapies.
  • OBJECTIVE: To assess the safety and efficacy of cryotherapy in esophageal carcinoma.
  • PATIENTS: Subjects with esophageal carcinoma in whom conventional therapy failed and those who refused or were ineligible for conventional therapy.
  • Treatment was complete when tumor eradication was confirmed by biopsy or when treatment was halted because of tumor progression, patient preference, or comorbid condition.
  • Tumor stage included T1-60, T2-16, and T3/4-3.
  • Mean tumor length was 4.0 cm (range 1-15 cm).
  • Benign stricture developed in 10 (13%), with esophageal narrowing from previous endoscopic resection, radiotherapy, or photodynamic therapy noted in 9 of 10 subjects.
  • CONCLUSIONS: Spray cryotherapy is safe and well tolerated for esophageal cancer.

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20363410.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA132892-04; United States / NCI NIH HHS / CA / K07 CA132892; United States / NCI NIH HHS / CA / K07 CA132892-04
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols
  • [Other-IDs] NLM/ NIHMS307178; NLM/ PMC3144145
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52. Lindsay PE, El Naqa I, Hope AJ, Vicic M, Cui J, Bradley JD, Deasy JO: Retrospective monte carlo dose calculations with limited beam weight information. Med Phys; 2007 Jan;34(1):334-46
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  • For the application here (normal lung, esophagus, and planning target volume dose distributions), the agreement was very good.
  • The entire dose-volume-histograms for lung, tumor, and esophagus from the different calculation methods, as well as specific dose metrics, were compared.

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  • (PMID = 17278519.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA85181; United States / NCI NIH HHS / CA / R01 CA90445
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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53. Chen JG, Zhu J, Parkin DM, Zhang YH, Lu JH, Zhu YR, Chen TY: Trends in the incidence of cancer in Qidong, China, 1978-2002. Int J Cancer; 2006 Sep 15;119(6):1447-54
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  • The indices of histological verification of diagnosis, death certificate only and proportion of mortality to incidence were employed for assessing the registration quality.
  • The leading cancer sites in rank were liver (average ASR = 50.8 per 100,000), stomach (26.7), lung (22.7), colon-rectum (8.9), oesophagus (7.4) and breast (5.4).
  • The cancers of high lethality that have been common in the Chinese population (liver, stomach, oesophagus) are showing some evidence of decline, at least in younger generations, but they remain major problems.

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  • (PMID = 16596645.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Fogel GR, McDonnell MF: Surgical treatment of dysphagia after anterior cervical interbody fusion. Spine J; 2005 Mar-Apr;5(2):140-4
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  • The hypothesis is that removal of the anterior cervical plate will release mechanical adhesions of the esophagus to the anterior spine around the plate.
  • RESULTS: The primary operative finding was extensive adhesions attaching the esophagus to the prevertebral fascia and anterior cervical spine around the periphery of the cervical plate.


55. Tsalis K, Vasiliadis K, Tsachalis T, Christoforidis E, Blouhos K, Betsis D: Management of Boerhaave's syndrome: report of three cases. J Gastrointestin Liver Dis; 2008 Mar;17(1):81-5
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  • One of them required further intervention with a cervical esophagostomy and exclusion of the perforated esophagus.
  • The third patient with an esophageal perforation related disorder, was managed with surgical exploration and drainage alone.
  • Primary suturing of the esophagus should be performed only in patients with an early perforation.
  • In cases of prolonged delay between rupture and diagnosis, esophageal resection with cervical esophagostomy and gastrostomy is advocated as the safest therapy.
  • [MeSH-major] Esophageal Perforation / diagnosis. Esophageal Perforation / surgery

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  • (PMID = 18392250.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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56. Fang FC, Tzao C, Cheng YL, Chan DC, Nieh S, Lee SC: Surgical treatment of gastrointestinal stromal tumor in the esophagus: report of three cases. Z Gastroenterol; 2007 Dec;45(12):1252-6
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  • [Title] Surgical treatment of gastrointestinal stromal tumor in the esophagus: report of three cases.
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the alimentary tract.
  • The term GIST was introduced in 2004 and understanding of the tumor's cellular origin, classification, diagnostic markers, and prognostic parameters has evolved dramatically over the last two decades.
  • In the esophagus, squamous cell carcinoma and adenocarcinoma are common malignant tumors and leiomyoma is the most frequent mesenchymal neoplasm.
  • Esophageal GISTs, however, have been reported less frequently.
  • METHODS: We report three cases of esophageal GISTs in patients who underwent surgical intervention in our institution.
  • Submucosal tumors were suspected after the patients underwent barium swallow and endoscopic studies.
  • In addition, positron emission tomography was used to study a submucosal tumor in one patient.
  • RESULTS: The pathological diagnosis was confirmed in all cases by microscopic examination with hematoxylin and eosin stain and positive immunoreaction for c-kit.
  • Two of them were low risk and the third one was high risk in character, according to the consensus approach and depending on the size and mitotic index of the tumor.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Biopsy. Deglutition Disorders / etiology. Diagnosis, Differential. Endoscopy, Digestive System. Endosonography. Esophagus / pathology. Frozen Sections. Humans. Male. Mitotic Index. Prognosis. Proto-Oncogene Proteins c-kit / analysis. Tomography, X-Ray Computed

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  • (PMID = 18080227.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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57. Konski A, Doss M, Milestone B, Haluszka O, Hanlon A, Freedman G, Adler L: The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma. Int J Radiat Oncol Biol Phys; 2005 Mar 15;61(4):1123-8
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  • [Title] The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma.
  • PURPOSE: Accurate delineation of the gross tumor volume (GTV) is important in radiation therapy treatment planning.
  • We evaluated the impact of PET and endoscopic ultrasound (EUS) compared with CT simulation in the planning of radiation fields for patients with esophageal carcinoma.
  • MATERIAL AND METHODS: Twenty-five patients presenting with esophageal carcinoma for radiation therapy underwent PET scans in the treatment position after conventional CT simulation.
  • Of the 18 patients who had EUS, 2 had T2 tumors and 16 had T3 tumors.
  • Nine tumors were located at the gastroesophageal junction, 8 at the lower esophagus, 7 in the middle esophagus, and 1 in the cervical esophagus.
  • The PET scans were reviewed to determine the length of the abnormality by use of a standard uptake value (SUV) of 2.5 to delineate the tumor extent.
  • The length of the tumors was significantly longer as measured by CT scans compared with PET scans (p = 0.0063).
  • The SUV of the esophageal tumors was higher in patients with peri-esophageal lymphadenopathy identified on PET scans.
  • CONCLUSION: Endoscopic ultrasound and PET scans can add additional information to aid the radiation oncologist's ability to precisely identify the GTV in patients with esophageal carcinoma.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Adenocarcinoma / ultrastructure. Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / ultrasonography. Esophageal Neoplasms / radionuclide imaging. Esophageal Neoplasms / ultrasonography. Radiotherapy Planning, Computer-Assisted / methods

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  • (PMID = 15752892.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Guillem PG: How to make a Barrett esophagus: pathophysiology of columnar metaplasia of the esophagus. Dig Dis Sci; 2005 Mar;50(3):415-24
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  • [Title] How to make a Barrett esophagus: pathophysiology of columnar metaplasia of the esophagus.
  • Barrett esophagus is defined as a specialized intestinal replacing the squamous epithelium of the esophageal mucosa in response to gastroesophageal reflux.
  • Barrett metaplasia is a healing process that develops to protect the esophagus from further damage.
  • Barrett esophagus develops when defense mechanisms in the esophageal mucosa (luminal secretion of mucus, bicarbonate, growth factors, etc.) are overwhelmed by an ongoing cycle of mucosal injury and repair.
  • Hydrogen ion, pepsin, trypsin, and bile acids are considered harmful agents that synergistically invade the esophageal mucosa.
  • Areas of destroyed squamous epithelium are then progressively reepithelized by a columnar epithelium that may originate from multipotent stem cells located within the basal layer of the normal esophageal mucosa or in the ducts of submucosal glands.
  • [MeSH-major] Barrett Esophagus / pathology. Cell Transformation, Neoplastic / pathology. Esophagus / pathology. Precancerous Conditions / pathology

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  • (PMID = 15810619.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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59. Sami SA, Rössel P, Dimcevski G, Nielsen KD, Funch-Jensen P, Valeriani M, Arendt-Nielsen L, Drewes AM: Cortical changes to experimental sensitization of the human esophagus. Neuroscience; 2006 Jun 19;140(1):269-79
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  • [Title] Cortical changes to experimental sensitization of the human esophagus.
  • We hypothesized that experimental sensitization of the esophagus results in changes of the topographical distribution of the evoked potentials and the corresponding dipole source activities to painful stimulation.
  • The findings indicate that short-term sensitization of the esophagus results in central neuroplastic changes involving the cingulate gyrus, which also showed pathological activation in functional diseases of the gut, thus reflecting the importance of this region in visceral pain and hyperalgesia.
  • [MeSH-major] Brain Mapping. Cerebral Cortex / physiology. Esophagus / innervation. Evoked Potentials, Somatosensory / physiology

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  • (PMID = 16631315.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] QTT17582CB / Hydrochloric Acid
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60. Falk GW, Goldblum JR: Extent of low-grade dysplasia in Barrett's esophagus: is it useful for risk stratification? Am J Gastroenterol; 2007 Mar;102(3):494-6
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  • [Title] Extent of low-grade dysplasia in Barrett's esophagus: is it useful for risk stratification?
  • Low-grade dysplasia remains one of the great enigmas of Barrett's esophagus.
  • [MeSH-major] Barrett Esophagus / pathology. Esophageal Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Prognosis. Risk Assessment / methods. Risk Factors. Severity of Illness Index

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  • [CommentOn] Am J Gastroenterol. 2007 Mar;102(3):483-93; quiz 694 [17338734.001]
  • (PMID = 17335444.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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61. Savoy AD, Wolfsen HC, Raimondo M, Woodward TA, Noh K, Pungpapong S, Hemminger LL, Wallace MB: The role of surveillance endoscopy and endosonography after endoscopic ablation of high-grade dysplasia and carcinoma of the esophagus. Dis Esophagus; 2008;21(2):108-13
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  • [Title] The role of surveillance endoscopy and endosonography after endoscopic ablation of high-grade dysplasia and carcinoma of the esophagus.
  • Barrett's esophagus (BE) with high-grade dysplasia (HGD) or early carcinoma treated with surgery or photodynamic therapy (PDT) is at risk of recurrence.
  • Our objective was to determine if EUS is superior to esophagogastroduodenoscopy (EGD) and/or CT scan for surveillance of BE neoplasia after PDT.

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  • (PMID = 18269644.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Smith MS, Lightdale CJ: Barrett's esophagus and the increasing role of endoluminal therapy. Therap Adv Gastroenterol; 2008 Sep;1(2):121-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Barrett's esophagus and the increasing role of endoluminal therapy.
  • Barrett's esophagus, or the presence of specialized intestinal mucosa in the esophagus that has a malignant potential, has experienced a rapid increase in diagnosis and prevalence over the past few decades.

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  • (PMID = 21180521.001).
  • [ISSN] 1756-283X
  • [Journal-full-title] Therapeutic advances in gastroenterology
  • [ISO-abbreviation] Therap Adv Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3002496
  • [Keywords] NOTNLM ; Barrett's esophagus / esophageal cancer / gastro-esophageal reflux disease
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63. Hamvas B, Szilágyi A, Orosz Z, Altorjay A: [Giant solitary fibrovascular polyp of the esophagus causing diagnostic problems]. Magy Seb; 2006 Apr;59(2):129-32
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  • [Title] [Giant solitary fibrovascular polyp of the esophagus causing diagnostic problems].
  • The giant fibrovascular polyp is a rear benign entity of the esophagus.
  • The authors present a case of a patient with a giant fibrovascular polyp caused serious diagnostic problems.
  • The preoperative examination confirmed a 60x50x90 mm size tumor-like intramural lesion in the upper third of the esophagus.
  • During the operation we found a sessile intraluminal polyp which has removed.
  • The histology confirmed giant fibrovascular polyp.
  • [MeSH-major] Esophageal Diseases / diagnosis. Esophageal Diseases / surgery. Polyps / diagnosis. Polyps / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16784037.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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64. Semeniuk J, Kaczmarski M: Gastroesophageal reflux (GER) in children and adolescents with regard to food intolerance. Adv Med Sci; 2006;51:321-6
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  • The diagnostic procedure included a 24 h pH-metry of the oesophagus, which was performed in all the study children.
  • Manometric examination of the oesophagus was performed in 232 children (123 boys--16.7% and 109 girls--14.8%).
  • RESULTS: Based on the 24 h pH-metry of the oesophagus and endoscopic examination of the upper gastrointestinal tract, gastroesophageal reflux disease and/or reflux oesophagitis were diagnosed in 138 study subjects (18.8%); mean age x = 23.36 months +/- 22.53.


65. Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, Fromkes JJ: Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer; 2006;54(1):148-56
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  • [Title] Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients.
  • Increased fruit and vegetable consumption is associated with decreased risk of a number of cancers of epithelial origin, including esophageal cancer.
  • Dietary administration of lyophilized black raspberries (LBRs) has significantly inhibited chemically induced oral, esophageal, and colon carcinogenesis in animal models.
  • We are currently conducting a 6-mo chemopreventive pilot study administering 32 or 45 g (female and male, respectively) of LBRs to patients with Barrett's esophagus (BE), a premalignant esophageal condition in which the normal stratified squamous epithelium changes to a metaplastic columnar-lined epithelium.
  • BE's importance lies in the fact that it confers a 30- to 40-fold increased risk for the development of esophageal adenocarcinoma, a rapidly increasing and extremely deadly malignancy.
  • [MeSH-major] Barrett Esophagus / therapy. Esophageal Neoplasms / prevention & control. Food Preservation. Fruit. Oxidative Stress. Rosaceae

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  • (PMID = 16800781.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Biomarkers; 27415-26-5 / 8-epi-prostaglandin F2alpha; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; B7IN85G1HY / Dinoprost; G9481N71RO / Deoxyguanosine
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66. Hayama M, Maeda H: A rare cause of dysphagia: malignant pleural mesothelioma in the posterior mediastinum. Ann Thorac Surg; 2010 Oct;90(4):1358-61
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  • A computed tomographic scan revealed a posterior mediastinal mass surrounding the lower portion of the esophagus.
  • Endoscopic examination demonstrated narrowing of the lower esophagus without malignant mucosal lesions.
  • Thoracoscopic biopsies of the mediastinal mass failed to yield a pathologic diagnosis.
  • The histopathologic and immunohistochemical findings of the biopsy were consistent with the diagnosis of pleural malignant mesothelioma.
  • [MeSH-major] Deglutition Disorders / etiology. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20868849.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / 1R21HL088527
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9004-61-9 / Hyaluronic Acid
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67. Wilson DV, Evans AT: The effect of topical treatment on esophageal pH during acid reflux in dogs. Vet Anaesth Analg; 2007 Sep;34(5):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of topical treatment on esophageal pH during acid reflux in dogs.
  • OBJECTIVE: To determine the effect of suction, lavage and instillation of sodium bicarbonate solution on esophageal pH during acidic gastro-esophageal reflux (GER) in anesthetized dogs.
  • A sensor-tipped catheter was used to measure esophageal pH.
  • On study entry the esophagus was suctioned.
  • After an interval of at least 5 minutes, if the esophageal pH was still less than 4 the esophagus was lavaged with tap water and again suctioned.
  • In 6 dogs 20 mL of dilute bicarbonate solution was instilled into the esophageal lumen.
  • RESULTS: Suctioning fluid from the esophagus did not change the pH significantly.
  • In all dogs where dilute bicarbonate solution was instilled, esophageal pH increased to above 6 for up to 180 (mean +/- SD, 89 +/- 81) minutes.
  • CONCLUSIONS AND CLINICAL RELEVANCE: Suctioning refluxate from the esophagus does not change the pH of the esophageal lumen.
  • Care must be taken that fluid is instilled into the lumen of the esophagus, and not into the trachea.
  • [MeSH-major] Anesthesia / veterinary. Dog Diseases / prevention & control. Esophagus / drug effects. Gastroesophageal Reflux / veterinary. Sodium Bicarbonate / pharmacology

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  • (PMID = 17565573.001).
  • [ISSN] 1467-2987
  • [Journal-full-title] Veterinary anaesthesia and analgesia
  • [ISO-abbreviation] Vet Anaesth Analg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 8MDF5V39QO / Sodium Bicarbonate
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68. Chapet O: [Acute and late toxicities in thoracic irradiation]. Cancer Radiother; 2007 Jan-Feb;11(1-2):92-100
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  • [Transliterated title] Complications aiguës et tardives des irradiations thoraciques.
  • Radiotherapy of lung cancer is often complexe because of several organs at risk such as lung, heart, esophagus or spinal cord.
  • The large number of parameters described for lung and esophagus highlights the necessity to perform an overall analysis of the DVHs that could be possible by using Nomal Tissue Complication Probability models.
  • [MeSH-minor] Esophagus / radiation effects. Heart / radiation effects. Humans. Lung / radiation effects. Models, Biological. Radiotherapy / adverse effects. Radiotherapy Dosage. Spinal Cord / radiation effects

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  • (PMID = 17291806.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 44
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69. Marom T, Goldfarb A, Russo E, Roth Y: Battery ingestion in children. Int J Pediatr Otorhinolaryngol; 2010 Aug;74(8):849-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Due to their electrochemical composition, impacted batteries in the esophagus may cause an extensive damage.
  • Plain PA chest film revealed a 2.5 cm diameter radiopaque round object in the upper esophagus.
  • It was not possible to visualize either the distal esophagus or the stomach.
  • A nasogastric tube was not inserted because of a significant risk for esophageal perforation if bluntly passed.
  • Upper digestive tract gastrografin swallow test performed 2 days after esophagoscopy did not demonstrate a leak from the esophagus, and oral feeding was carefully re-initiated.
  • Signs and symptoms of ingested battery are related to impaction duration, size of battery, battery content and peristaltic waves of the esophagus.
  • Esophageal stenting and adjuvant medical therapy (steroid therapy, antibiotic therapy and anti-reflux therapy) have a low evidence level of clinical benefit following caustic injuries from impacted batteries and spillage of their content to the esophagus.
  • [MeSH-major] Electric Power Supplies / adverse effects. Esophagus. Foreign Bodies / epidemiology. Foreign Bodies / therapy

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20538351.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
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70. Endo T, Yamashita K, Shinomura Y: [Diagnosis of Barrett's esophagus and Barrett's carcinoma using magnifying endoscopy]. Nihon Rinsho; 2005 Aug;63(8):1399-404
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  • [Title] [Diagnosis of Barrett's esophagus and Barrett's carcinoma using magnifying endoscopy].
  • Specialized columnar epithelium (SCE) in Barrett's esophagus has been detected by random or four quadrant biopsy using conventional endoscopy; however little is known about the fine mucosal structure of SCE.
  • [MeSH-major] Barrett Esophagus / diagnosis. Barrett Esophagus / pathology. Esophagoscopes. Esophagoscopy / methods
  • [MeSH-minor] Diagnosis, Differential. Esophagus / pathology. Humans. Mucous Membrane / pathology

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  • (PMID = 16101229.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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71. Knebel C, Bumm R, Becker K, Burian M, Siewert JR: [Rare occurrence of fulminant acid burn of the esophagus]. Chirurg; 2008 Aug;79(8):765-70
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  • [Title] [Rare occurrence of fulminant acid burn of the esophagus].
  • [Transliterated title] Seltene Ursache einer fulminanten Säureverätzung des Osophagus.
  • In this case report a 55-year-old man had a medical history of esophageal reflux, vomiting, and diarrhea for 10 years.
  • A diagnosis of gastrinoma was at first not considered.
  • After discontinuation of the proton pump inhibitor for only a few days, the strong stimulation of the gastrinoma led to fulminant hydrochloric acid burn of the distal esophagus with iatrogenic or spontaneous perforation at the esophagogastral junction.
  • We describe the operative treatment as a two-stage reconstruction with colon interposition and resection of the primary tumor in the duodenum.
  • [MeSH-major] Duodenal Neoplasms / complications. Duodenal Neoplasms / surgery. Esophageal Perforation / surgery. Esophagitis, Peptic / surgery. Gastrinoma / complications. Gastrinoma / surgery
  • [MeSH-minor] Anti-Ulcer Agents / administration & dosage. Disease Progression. Duodenum / pathology. Duodenum / surgery. Endoscopy, Digestive System. Esophagectomy. Esophagus / pathology. Follow-Up Studies. Gastrectomy. Gastric Mucosa / pathology. Gastroesophageal Reflux / diagnosis. Gastroesophageal Reflux / pathology. Gastroesophageal Reflux / surgery. Humans. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Middle Aged. Necrosis. Proton Pump Inhibitors. Reoperation. Treatment Refusal. Zollinger-Ellison Syndrome / diagnosis. Zollinger-Ellison Syndrome / pathology. Zollinger-Ellison Syndrome / surgery

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  • (PMID = 17879075.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors
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72. Giblin EM, Reed CE: Diffuse esophageal polyposis: an uncommon occurrence. Ann Thorac Surg; 2009 Apr;87(4):1258-60
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  • [Title] Diffuse esophageal polyposis: an uncommon occurrence.
  • The presence of multiple esophageal polyps on endoscopy is a rare entity.
  • We present a case of a 66-year-old woman with a history of gastroesophageal reflux disease that was found to have extensive esophageal polyposis of the mid-esophagus on upper endoscopy.
  • Final pathology was consistent with extensive polypoid dysplasia in the presence of Barrett's esophagus.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Aged. Barrett Esophagus / complications. Esophagectomy. Esophagoscopy. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 19324163.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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73. Chello M, Lusini M, Spadaccio C, Covino E: Dysphagia soon after off-pump coronary surgery: the single suture technique. Eur J Cardiothorac Surg; 2007 Oct;32(4):667-8
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  • Multislice spiral computed tomography showed a 6 cm x 2.5 cm solid formation next to the posterior wall of the left atrium, adjacent to the pericardium and the right anterolateral side of the esophagus.
  • The mass was confirmed to be an intramural esophageal hematoma by endoscopic ultrasound-guided fine-needle aspiration cytology.
  • Injury to esophagus during the placement of deep pericardial sutures and postoperative infusion of heparin are claimed to be causes of this complication.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / adverse effects. Coronary Disease / surgery. Deglutition Disorders / etiology. Esophageal Diseases / complications. Hematoma / complications

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  • (PMID = 17651979.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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74. Gutmann EJ, Suriawinata A, Gordon S: Barrett's esophagus with high-grade dysplasia simulating metastatic adenocarcinoma in a fine needle aspiration biopsy. Diagn Cytopathol; 2006 Jul;34(7):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Barrett's esophagus with high-grade dysplasia simulating metastatic adenocarcinoma in a fine needle aspiration biopsy.
  • An endoscopic ultrasound examination, performed to rule out invasive esophageal carcinoma in a patient with a history of Barrett's esophagus with high-grade dysplasia, disclosed an enlarged paraesophageal lymph node which was aspirated.
  • The case represents a rare instance in which Barrett's esophagus with high-grade dysplasia was discerned on fine needle aspiration (FNA) biopsy and highlights a potential pitfall in FNA.
  • [MeSH-major] Adenocarcinoma / secondary. Barrett Esophagus / pathology. Biopsy, Fine-Needle. Esophageal Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Endoscopy, Gastrointestinal. Endosonography. Humans. Male. Treatment Outcome

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783781.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Shimoda T, Koizumi W, Tanabe S, Higuchi K, Sasaki T, Nakayama N, Azuma M, Saigenji K, Katou T, Ogino M: Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documenting a complete response. Jpn J Clin Oncol; 2006 Feb;36(2):109-12
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  • [Title] Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documenting a complete response.
  • We describe a case of small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome.
  • Small-cell carcinoma of the esophagus was incidentally diagnosed while investigating the cause of the neurological symptoms.
  • There was a complete response to three courses of chemoradiotherapy, with no evidence of disease recurrence 6 years after the diagnosis.
  • [MeSH-major] Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy. Paraneoplastic Syndromes, Nervous System / etiology

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  • (PMID = 16517835.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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76. Cuevas Hernández MM, Arias Hernández RM: [Pulmonary gammagraphy study in asthmatic children with gastroesophageal reflux]. Rev Alerg Mex; 2008 Nov-Dec;55(6):229-33
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  • [Transliterated title] Estudio de gammagrafía pulmonar en niños asmáticos con reflujo gastroesofágico.
  • BACKGROUND: The asthmatic children who do not respond favorably to the specifically anti-allergic treatment, and also begin their breathlessness crisis preferably at night, are suspicious of suffering gastric-esophagus reflux that stimulate bronchial spasm crisis by means of an aspiration mechanism, or more frequently, by means of a reflective mechanism through the vagal via.
  • OBJECTIVES: To know probable physiopathologic mechanism of gastric-esophagus reflux that exacerbates asthmatic crisis.
  • MATERIAL AND METHODS: There were chosen 50 moderate-severe persistent asthmatic patients with non favorable evolution and gastric-esophagus reflux.
  • The diagnosis was settled by means of radiological study, with barium contrast in esophagus, stomach and duodenum, and esophagus-pulmonary gammagraphy with technetium 99 (99mTc).


77. Chang CY, Lee YC, Lee CT, Tu CH, Hwang JC, Chiang H, Tai CM, Chiang TH, Wu MS, Lin JT: The application of Prague C and M criteria in the diagnosis of Barrett's esophagus in an ethnic Chinese population. Am J Gastroenterol; 2009 Jan;104(1):13-20
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  • [Title] The application of Prague C and M criteria in the diagnosis of Barrett's esophagus in an ethnic Chinese population.
  • OBJECTIVES: To investigate the prevalence of endoscopically suspected esophageal metaplasia (ESEM) in an ethnic Chinese population by endoscopic and pathologic evaluation and to assess the utility of Prague C and M criteria.
  • METHODS: Consecutive patients who received esophagogastroduodenoscopy either as a part of therapy for various upper abdominal symptoms or as an annual health check-up were evaluated for the existence of ESEM and Barrett's esophagus (BE).
  • Biopsy with standardized random four pieces every 2 cm from the four quarters of esophagus with ESEM lesion was performed.
  • [MeSH-major] Asian Continental Ancestry Group. Barrett Esophagus / diagnosis
  • [MeSH-minor] Endoscopy, Digestive System. Esophagitis / diagnosis. Esophagitis / epidemiology. Esophagitis / pathology. Female. Humans. Male. Middle Aged. Prevalence. Taiwan / epidemiology

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  • (PMID = 19098843.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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78. Korsapati H, Babaei A, Bhargava V, Dohil R, Quin A, Mittal RK: Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis. Gut; 2009 Aug;58(8):1056-62
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  • [Title] Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis.
  • BACKGROUND: Oesophageal motility, as measured by manometry, is normal in the majority of patients with eosinophilic oesophagitis (EO).
  • However, manometry measures only the circular muscle function of the oesophagus.
  • A probe with an ultrasound transducer was positioned 2 cm and then 10 cm above the lower oesophageal sphincter and five, 5 ml water swallows were recorded before and after edrophonium.
  • However, changes in the muscle thickness (a marker of longitudinal muscle contraction) are markedly diminished in patients with EO, at both 2 and 10 cm above the lower oesophageal sphincter.
  • [MeSH-major] Eosinophilia / physiopathology. Esophagitis / physiopathology. Esophagus / physiopathology. Muscle, Smooth / physiopathology

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  • [CommentIn] Gut. 2009 Aug;58(8):1041-2 [19592685.001]
  • (PMID = 19136515.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R0-1DK060733
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cholinesterase Inhibitors; 70FP3JLY7N / Edrophonium
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79. Karagülle E, Akkaya D, Türk E, Göktürk HS, Yildirim E, Moray G: Giant leiomyoma of the esophagus: a case report and review of the literature. Turk J Gastroenterol; 2008 Sep;19(3):180-3
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  • [Title] Giant leiomyoma of the esophagus: a case report and review of the literature.
  • Although leiomyoma is the most common esophageal mesenchymal neoplasm, it is a rare condition.
  • Resection of the tumor is recommended in symptomatic patients, and observation is recommended in asymptomatic patients with small lesions.
  • We discuss herein a patient admitted to our outpatient clinic for dyspepsia in whom a giant annular esophageal leiomyoma was diagnosed.
  • Resection through thoracoabdominal approach is recommended instead of adjuvant treatment in similar sized tumors.
  • [MeSH-major] Esophageal Neoplasms / surgery. Leiomyoma / surgery

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  • (PMID = 19115154.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 17
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80. Scherübl H, Steinberg J, Schwertner C, Mir-Salim P, Stölzel U, de Villiers EM: [Coincidental squamous cell cancers of the esophagus, head, and neck: risk and screening]. HNO; 2008 Jun;56(6):603-8
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  • [Title] [Coincidental squamous cell cancers of the esophagus, head, and neck: risk and screening].
  • Patients suffering from head and neck cancer (HNC) have or develop a second esophageal squamous cell cancer (ESCC) or bronchial cancer (BC) in 5-14% of cases.
  • When a second esophageal cancer occurs in a patient with HNC, the prognosis is generally determined by the ESCC, and, unfortunately, it is poor.
  • Screening and surveillance by Lugol chromoesophagoscopy enable early detection and curative treatment of second esophageal neoplasias.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Esophageal Neoplasms / genetics. Head and Neck Neoplasms / diagnosis. Mass Screening / methods. Neoplasms, Multiple Primary / diagnosis. Population Surveillance / methods. Risk Assessment / methods

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  • (PMID = 17928979.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 42
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81. Stubberud ES, Jacobs JP, Harmel RP Jr, Andrews T, Chai PJ, Lindberg HL, Quintessenza JA: Successful reconstruction of traumatic carinal tissue loss using the esophagus in an infant. Ann Thorac Surg; 2007 Sep;84(3):1031-3
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  • [Title] Successful reconstruction of traumatic carinal tissue loss using the esophagus in an infant.
  • We present a case report of an infant who underwent successful reconstruction of a traumatic tracheal and carinal chemically induced corrosive injury using an esophageal flap to reconstruct the trachea and subsequently re-establishing gastrointestinal continuity with a colon interposition.
  • [MeSH-major] Esophagus / surgery. Trachea / injuries. Trachea / surgery

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  • (PMID = 17720432.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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82. Gockel I, Junginger T, Eckardt VF: Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysis. J Gastrointest Surg; 2006 Dec;10(10):1400-8
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  • Enrolled in this study were 108 patients with a conventional, transabdominal myotomy in combination with an anterior semifundoplication (Dor procedure) and a minimal follow-up of 6 months.
  • All patients were prospectively followed and, in addition to radiologic and manometric examinations of the esophagus, the patients were asked for their clinical symptoms by structured interviews in 2-year intervals.
  • The radiologically measured maximum diameter of the esophagus decreased from preoperatively 45 (range, 20-75) mm to postoperatively 30 (range, 20-60) mm, while the minimum diameter of the cardia increased from 3.4 (range, 1-10) mm to 10 (range, 5-15) mm.
  • The resting pressure of the lower esophageal sphincter could be reduced from 28.4 (range, 9.4-56.0) mm Hg to 8.6 (range, 3.0-22.5) mm Hg.
  • [MeSH-major] Esophageal Achalasia / surgery. Fundoplication
  • [MeSH-minor] Adolescent. Adult. Aged. Body Mass Index. Catheterization. Esophageal Sphincter, Lower / physiopathology. Female. Humans. Male. Manometry. Middle Aged. Pressure. Prognosis. Prospective Studies. Treatment Outcome

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  • (PMID = 17175461.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Csendes P, Csendes A, Cortes C, Burgos AM: Evolutive radiological changes of the esophagus in patients with achalasia who did not receive treatment. Surg Today; 2007;37(3):183-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolutive radiological changes of the esophagus in patients with achalasia who did not receive treatment.
  • PURPOSE: The radiological features of achalasia of the esophagus are well known and have been described.
  • We aimed to determine the evolutive radiological changes of the esophagus in a group of patients with achalasia who had not previously undergone any treatment.
  • They included 9 women and 5 men who did not receive any treatment at the initial diagnosis.
  • Two radiological parameters were evaluated: (a) the maximal internal diameter of the middle third of the thoracic esophagus in millimeters and (b) the internal diameter of the esophagogastric junction in millimeters.
  • RESULTS: At a mean follow-up of 5-years without any treatment, there was a significant increase in the diameter of the thoracic esophagus, with a rate of "dilatation" of 6.1 mm/year.
  • The lower esophageal sphincter was hypertensive in all with an incomplete relaxation.
  • CONCLUSION: These results suggest that there is a progressive deterioration in the radiological parameters of the esophagus in patients with achalasia not treated over a 5-year period of observation.
  • [MeSH-major] Esophageal Achalasia / diagnostic imaging. Esophagus / diagnostic imaging

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  • (PMID = 17342353.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Japan
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84. Bollschweiler E, Wolfgarten E, Pütz B, Gutschow C, Hölscher AH: Bile reflux into the stomach and the esophagus for volunteers older than 40 years. Digestion; 2005;71(2):65-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bile reflux into the stomach and the esophagus for volunteers older than 40 years.
  • BACKGROUND: An increased incidence of Barrett's esophagus in cases with combined acidic and bile reflux is reported.
  • The aim of this study was to analyze bile reflux patterns of healthy volunteers aged comparably to patients with Barrett's esophagus.
  • Indicators for bile reflux in the stomach and esophagus: bilirubin probe absorption >0.25 in total measuring period (TM), upright position (excluding postprandial periods) (UP) and supine period (SP).
  • In 10/19 older volunteers and in 18/20 younger volunteers, no reflux of bile into the esophagus was measured.
  • CONCLUSION: No significant differences in bile reflux into the stomach were distinguishable between younger and older healthy volunteers, but older volunteers more frequently exhibited bile reflux into the esophagus.
  • [MeSH-major] Barrett Esophagus / physiopathology. Bilirubin / analysis. Duodenogastric Reflux

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • [CommentIn] Digestion. 2005;71(2):63-4 [15775672.001]
  • (PMID = 15775673.001).
  • [ISSN] 0012-2823
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] RFM9X3LJ49 / Bilirubin
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85. Chernousov AF, Ruchkin DV, Chernousov FA, Kebedov MM: [Experience in repeated esophagoplasty]. Khirurgiia (Mosk); 2005;(5):14-9
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  • Fifty-four patients of them had reoperation because of incomplete plastic reconstruction, 4 patients -- because of artificial esophagus (cancer, papillomatosis, trauma) diseases.
  • Primary esophagoplasty in 47 patients was performed due to burn stricture of the esophagus, in 9 -- due to cancer of the cardia and esophagus, in 1 -- due to peptic stricture, and in 1 -- due to leiomyoma of the esophagus.
  • Subtotal repeated reconstruction of the esophagus was performed in 34 patients, total -- in 21, segmental (with a fragment of the intestine on a long vascular pedicle) -- in 3 patients.
  • [MeSH-major] Esophageal Stenosis / surgery. Esophagoplasty / methods

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  • (PMID = 16007018.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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86. Lin OS, Schembre DB, Mergener K, Spaulding W, Lomah N, Ayub K, Brandabur JJ, Bredfeldt J, Drennan F, Gluck M, Jiranek GC, McCormick SE, Patterson D, Kozarek RA: Blinded comparison of esophageal capsule endoscopy versus conventional endoscopy for a diagnosis of Barrett's esophagus in patients with chronic gastroesophageal reflux. Gastrointest Endosc; 2007 Apr;65(4):577-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Blinded comparison of esophageal capsule endoscopy versus conventional endoscopy for a diagnosis of Barrett's esophagus in patients with chronic gastroesophageal reflux.
  • BACKGROUND: Esophageal capsule endoscopy (ECE) is an alternative to EGD for Barrett's esophagus screening.
  • OBJECTIVE: To assess the accuracy of ECE for the diagnosis of Barrett's esophagus.
  • PATIENTS: Screening patients with chronic gastroesophageal reflux and surveillance patients with known Barrett's esophagus.
  • MAIN OUTCOME MEASUREMENTS: Sensitivity, specificity, and positive and negative predictive values of ECE for Barrett's esophagus by using EGD results, with histologic confirmation as the criterion standard.
  • ECE was 67% sensitive and 84% specific for identifying Barrett's esophagus, diagnosing 14 of 21 cases of biopsy-confirmed Barrett's esophagus.
  • Sensitivity for short- and long-segment Barrett's esophagus was similar.
  • CONCLUSIONS: Our blinded, unadjudicated study shows that ECE had only moderate sensitivity and specificity for identifying Barrett's esophagus.
  • ECE in its present form is not suitable as a primary screening tool for Barrett's esophagus but may be used in patients unwilling to undergo EGD.
  • [MeSH-major] Barrett Esophagus / diagnosis. Capsule Endoscopy. Esophagoscopy


87. Waxman I, Konda VJ: Endoscopic techniques for recognizing neoplasia in Barrett's esophagus: which should the clinician use? Curr Opin Gastroenterol; 2010 Jul;26(4):352-60
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  • [Title] Endoscopic techniques for recognizing neoplasia in Barrett's esophagus: which should the clinician use?
  • PURPOSE OF REVIEW: The key to prevention and cure of esophageal adenocarcinoma is the detection and eradication of neoplasia in patients with Barrett's esophagus.
  • A variety of imaging modalities are being studied for the detection of neoplasia in Barrett's esophagus.
  • SUMMARY: The key to detection of neoplasia is a careful white light examination with high-resolution endoscopy and recognition of lesion characteristics.
  • [MeSH-major] Adenocarcinoma / diagnosis. Barrett Esophagus / pathology. Esophageal Neoplasms / diagnosis. Esophagoscopy / methods

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  • (PMID = 20571387.001).
  • [ISSN] 1531-7056
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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88. Odze RD: Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective. Am J Gastroenterol; 2005 Aug;100(8):1853-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The gastroesophageal junction (GEJ), which is defined as the point where the distal esophagus joins the proximal stomach (cardia), is a short anatomic area that is commonly exposed to the injurious effects of GERD and/or Helicobacter pylori infection.
  • The true gastric cardia is an extremely short segment (<0.4 mm) of mucosa that is typically composed of pure mucous glands, or mixed mucous/oxyntic glands that are histologically indistinguishable from metaplastic mucinous columnar epithelium of the distal esophagus.
  • In patients with GERD, whether physiologic or pathologic, the length of cardia-type epithelium increases and extends proximally above the level of the anatomic GEJ into the distal esophagus.
  • Columnar metaplasia of the distal esophagus represents a squamous to columnar metaplastic reaction that develops from an esophageal stem cell and may pass through an intermediate phase characterized by the presence of a type of epithelium that possesses a mixture of squamous and columnar features, termed multilayered epithelium.
  • The frequency of IM is probably greater in metaplastic columnar epithelium in the esophagus secondary to GERD, than in cases of true gastric carditis secondary to H. pylori, and may be a reason why there is a higher risk of carcinoma in the former compared to the latter.
  • A variety of clinical, endoscopic, histologic, and histochemical methods can be used to distinguish GERD-induced columnar metaplasia of the distal esophagus from H. pylori-induced inflammation of true gastric cardia, and these are outlined in this review, but further controlled studies are needed to critically evaluate these techniques.
  • [MeSH-minor] Cardia / pathology. Esophageal Neoplasms / pathology. Gastric Mucosa / pathology. Gastroesophageal Reflux / pathology. Humans. Metaplasia. Mucous Membrane / pathology

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  • [CommentIn] Am J Gastroenterol. 2006 Feb;101(2):407-8 [16454856.001]
  • [CommentIn] Am J Gastroenterol. 2006 Jan;101(1):199; author reply 199-200 [16405557.001]
  • (PMID = 16144130.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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89. Hung JJ, Li AF, Liu JS, Lin YS, Hsu WH: Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. Ann Thorac Surg; 2008 Mar;85(3):1102-4
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  • [Title] Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma.
  • Carcinosarcoma of the esophagus is a rare malignant neoplasm.
  • It often presents as a large intraluminal polypoid tumor with early onset of symptoms resulting in prompt diagnosis.
  • We present here the first case of a carcinosarcoma of the esophagus that had a basaloid squamous cell carcinoma component in addition to the osteosarcoma and without a transitional zone.
  • A 57-year-old man was diagnosed with a polypoid tumor in middle third of the esophagus causing dysphagia.
  • Local recurrence and solitary pulmonary metastasis occurred 16 and 30 months after initial excision of the tumor, respectively.
  • Prompt and aggressive surgical resection is mandatory for carcinosarcoma of the esophagus.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinosarcoma / pathology. Esophageal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology


90. Kang W, Wang H, Pan Y, Jenkins MW, Isenberg GA, Chak A, Atkinson M, Agrawal D, Hu Z, Rollins AM: Endoscopically guided spectral-domain OCT with double-balloon catheters. Opt Express; 2010 Aug 2;18(16):17364-72
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  • Fourier-domain optical coherence tomography (OCT) and balloon-based catheters have furthered the potential of OCT as a real-time surveillance tool for Barrett's esophagus (BE).
  • However, a balloon catheter, which expands the esophagus and centers the catheter, applies direct pressure on the esophagus.
  • A system design based on a spectral-domain OCT platform is reported and validated by acquisition of high quality, volumetric images of swine esophagus in vivo.

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  • (PMID = 20721123.001).
  • [ISSN] 1094-4087
  • [Journal-full-title] Optics express
  • [ISO-abbreviation] Opt Express
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA114276; United States / NIBIB NIH HHS / EB / R03 EB004044-01; United States / NIBIB NIH HHS / EB / R03 EB004044; United States / NIBIB NIH HHS / EB / T32 EB007509; United States / NHLBI NIH HHS / HL / R01 HL 083048; United States / NHLBI NIH HHS / HL / R01 HL083048
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3408909
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91. Pei YX, Heng ZC, Duan GC, Wang MC: [The mechanisms and effects of lutein on inducing the cell differentiation of human esophagus cancer EC9706]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2007 Jul;38(4):629-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The mechanisms and effects of lutein on inducing the cell differentiation of human esophagus cancer EC9706].
  • OBJECTIVE: The purpose of the study was to explore the effects and molecular mechanisms of lutein on the differentiation of esophagus cancer EC9706 cell.
  • CONCLUSION: Lutein can inhibit the proliferation of EC9706 cell, and promote the cancer cell differentiation. cyclin D1 may be involved in cell proliferation and differentiation events in esophageal cancer EC9706 cell, which is regulated by lutein.
  • [MeSH-major] Cell Differentiation / drug effects. Esophageal Neoplasms / pathology. Lutein / pharmacology
  • [MeSH-minor] Cell Cycle / drug effects. Cell Line, Tumor. Cell Proliferation / drug effects. Cyclin D1 / metabolism. Gene Expression Regulation, Neoplastic / drug effects. Humans

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  • (PMID = 17718427.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1; X72A60C9MT / Lutein
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92. Amegbor K, Napo-Koura GA, Songne-Gnamkoulamba B, Redah D, Tekou A: Epidemiological and pathological aspects of gastrointestinal tumors in Togo. Gastroenterol Clin Biol; 2008 Apr;32(4):430-4
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  • [Title] Epidemiological and pathological aspects of gastrointestinal tumors in Togo.
  • PURPOSE: The incidence of gastrointestinal tumors is difficult to estimate in Togo, so the purpose of this report was to describe the tumors diagnosed by the national pathology laboratory.
  • METHODS: This was a retrospective descriptive study of 742 gastrointestinal tumors diagnosed between 1986 and 2005 by the pathology laboratory of the Tokoin university hospital in Lomé, Togo.
  • RESULTS: There was an annual incidence of 37 gastrointestinal tumors, including 27 cancers, with twice as many tumors diagnosed in men as in women.
  • The average age of patients diagnosed with a benign tumor was 44 years compared with 52 years for those with a malignant tumor.
  • Stomach tumors predominated (n=306; 41.2%).
  • Papilloma was the most frequent benign tumor type (n=100; 47.8%), while malignant tumors were mostly gastric adenocarcinoma (n=224; 42% of all cancers), esophageal squamous cell carcinoma (n=100; 19%) and colorectal adenocarcinoma (n=89; 17%).
  • CONCLUSION: Gastrointestinal tumors are frequently seen in Togo, and an epidemiological monitoring program is needed.

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  • (PMID = 18359594.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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93. Vogel Y, Keilmann O, Jochheim R, Tannapfel A: [A rare cause of haematemesis with fatal gastrointestinal bleeding]. Internist (Berl); 2010 Aug;51(8):1053-6
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  • The subsequent high urgency upper endoscopy identified a circular mucosal defect in distal esophagus as bleeding origin.
  • Performing autopsy, a fistula between the thoracic aortic aneurysm and the distal esophagus was found in the background of severe arteriosclerosis.
  • [MeSH-major] Aneurysm, Infected / complications. Aneurysm, Ruptured / complications. Aortic Aneurysm, Thoracic / complications. Esophageal Fistula / complications. Gastrointestinal Hemorrhage / etiology. Hematemesis / etiology. Staphylococcal Infections / complications. Vascular Fistula / complications
  • [MeSH-minor] Aged. Aorta, Thoracic / pathology. Arteriosclerosis / complications. Arteriosclerosis / pathology. Diagnosis, Differential. Esophageal Perforation / complications. Esophageal Perforation / pathology. Esophagus / pathology. Fatal Outcome. Humans. Male

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  • (PMID = 20458458.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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94. Lakatos PL, Lakatos L, Fuszek P, Lukovich P, Kupcsulik P, Halbász J, Schaff Z, Papp J: [Incidence and pathologic distribution of esophageal cancers at the gastro-esophageal junction between 1993-2003]. Orv Hetil; 2005 Feb 27;146(9):411-6
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  • [Title] [Incidence and pathologic distribution of esophageal cancers at the gastro-esophageal junction between 1993-2003].
  • There was a significant change in the histology of oesophageal cancers in the last few decades.
  • The incidence of oesophageal adenocarcinoma has risen considerably, now it is equally or even more prevalent than squamous cell cancers in some North American and Western European countries.
  • As no Hungarian data is available, the authors' aim was to investigate the prevalence and histology of oesophageal and gastrooesophageal junction cancers in the last decade.
  • PATIENTS AND METHODS: 451 patients diagnosed with oesophageal (n = 371, 296 male/75 female, mean age at diagnosis: 57.9 SD 10.1 years) or cardia (n = 80, 58 male/22 female, mean age at diagnosis: 65.2 SD 13.4 years) cancer between 1st of January 1993 and 31st of December 2003 at the 1st Internal Medicine and 1st Surgery Department of Semmelweis University were enrolled.
  • RESULTS: 93% (n = 345) of the patients with oesophageal cancer had squamous cell carcinomas, while adenocarcinoma was only diagnosed in 15 (4%) patients.
  • Mean age at diagnosis was lower in patients with squamous cell cancer (57.4 SD 10.0 years) compared to patients with adenocarcinoma (66.9 SD 8.8 years, p = 0.001).
  • According to the location 1.3% of cancers of the midthoracic oesophagus and 8.6% of the lower oesophagus were adenocarcinoma.
  • In contrast, 71.25% (57/80) of the gastrooesophageal junction cancers and overall 15.9% (72/451) of the cancers of the oesophagus and gastrooesophageal junction were adenocarcinoma (1993-1997: 17.2% vs. 1998-2003: 14.7%).
  • CONCLUSIONS: Since only a few percentages of authors patients with oesophageal cancers were diagnosed to have adenocarcinoma and its proportion remained stable over the observed period, it seems that in contrast to North American and Western European countries, adenocarcinoma is still infrequent in Hungary.
  • [MeSH-major] Esophageal Neoplasms / epidemiology. Esophageal Neoplasms / pathology. Esophagogastric Junction / pathology

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  • (PMID = 15830608.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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95. Jones K, Pacella J, Wasty F: Hodgkin's disease of the oesophagus: a literature review. Australas Radiol; 2007 Oct;51(5):489-91
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  • [Title] Hodgkin's disease of the oesophagus: a literature review.
  • Primary Hodgkin disease of the oesophagus seems to be extremely rare.
  • We report a case of classical Hodgkin's disease involving lower end of oesophagus.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Hodgkin Disease / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Esophagoscopy. Female. Humans. Neoplasm Staging. Radiotherapy Dosage

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  • (PMID = 17803804.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 13
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96. Crespo Pérez L, Rivero Fernández M, García Aguilera XA, López San Román A, Boixeda de Miquel D, Benita León V, González Martín JA, Milicua Salamero: [Hairy esophagus: a complication of pharyngo-esophageal reconstructive surgery]. Rev Esp Enferm Dig; 2008 May;100(5):294-5
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  • [Title] [Hairy esophagus: a complication of pharyngo-esophageal reconstructive surgery].
  • [Transliterated title] Hairy esophagus: una complión de la cirugía reconstricva faringoesofágica.
  • [MeSH-major] Deglutition Disorders / etiology. Esophagus / surgery. Hair. Pharyngostomy. Surgical Flaps / adverse effects

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  • (PMID = 18662082.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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97. Griffin SM, Lamb PJ, Shenfine J, Richardson DL, Karat D, Hayes N: Spontaneous rupture of the oesophagus. Br J Surg; 2008 Sep;95(9):1115-20
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  • [Title] Spontaneous rupture of the oesophagus.
  • BACKGROUND: The aim of this study was to evaluate the diagnosis, management and outcome of patients with spontaneous rupture of the oesophagus in a single centre.
  • METHODS: Between October 1993 and May 2007, 51 consecutive patients with spontaneous oesophageal rupture were evaluated with contrast radiology and flexible endoscopy.
  • RESULTS: The median time to diagnosis was 24 (range 4-604) h.
  • Initial diagnosis was by contrast swallow in 18 of 24 patients, computed tomography in 15 of 17 and endoscopy in 18 of 18.
  • Of 31 patients who underwent primary thoracotomy and oesophageal repair (over a Ttube in 29), 11 died in hospital.
  • CONCLUSION: Spontaneous oesophageal rupture represents a spectrum of disease.
  • [MeSH-major] Esophageal Diseases. Thoracotomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media / administration & dosage. Drainage. Early Diagnosis. Female. Hospital Mortality. Humans. Length of Stay. Male. Middle Aged. Prospective Studies. Rupture, Spontaneous. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • [CommentIn] Br J Surg. 2009 Aug;96(8):951; author reply 951-2 [19591155.001]
  • [CommentIn] Br J Surg. 2008 Dec;95(12):1541 [18991313.001]
  • (PMID = 18655213.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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98. Yannopoulos P, Manes K: Giant fibrovascular polyp of the esophagus - imaging techniques can localize, preoperatively, the origin of the stalk and designate the way of surgical approach: a case report. Cases J; 2009;2:6854
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  • [Title] Giant fibrovascular polyp of the esophagus - imaging techniques can localize, preoperatively, the origin of the stalk and designate the way of surgical approach: a case report.
  • Fibrovascular polyps of the esophagus are rare benign lesions that arise from the cervical esophagus and can reach very big size before they become symptomatic.
  • We consider the accurate pre-operative assessment of the origin of the pedicle essential for the proper surgical treatment of such a polyp.
  • In respect to this, imaging provides important information concerning the exact location of the pedicle, the vascularity of the polyp and even tissue elements of the mass.

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  • (PMID = 19829872.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740314
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99. Lin X, Finkelstein SD, Zhu B, Ujevich BJ, Silverman JF: Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy. Cancer; 2009 Feb 25;117(1):57-66
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  • [Title] Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy.
  • BACKGROUND: Esophageal brushing cytology (EBC) and gastroesophageal biopsy (GEB) are complementary procedures for the evaluation of gastroesophageal lesions that help guide surveillance and treatment.
  • METHODS: The authors investigated loss of heterozygosity (LOH) of 17 microsatellite repeat markers near tumor suppressor genes in gastroesophageal lesions on 34 concomitant EBCs and GEBs.
  • The authors also found that LOHs at 1p36, 9p21, and 17p13 may play an important role in Barrett esophagus (BE), LOHs at 10q23, 17p13, and 17q12 in low-grade dysplasia (LGD), LOHs at 5q23 and 17q21 in high-grade dysplasia (HGD), and LOHs at 5q23 and 21q22 in adenocarcinoma.
  • CONCLUSIONS: Detection of LOHs targeting tumor suppressor genes can be useful in evaluating gastroesophageal lesions, studying oncogenesis of gastroesophageal adenocarcinoma, and, in combination with EBC and GEB, determining surveillance for BE and LGD and/or treatment for HGD and adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Barrett Esophagus / genetics. Cell Transformation, Neoplastic / genetics. Cytodiagnosis / methods. Esophageal Neoplasms / genetics. Precancerous Conditions / genetics

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19347831.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Chak A, Ochs-Balcom H, Falk G, Grady WM, Kinnard M, Willis JE, Elston R, Eng C: Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction. Cancer Epidemiol Biomarkers Prev; 2006 Sep;15(9):1668-73
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  • [Title] Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction.
  • BACKGROUND AND AIM: The familial aggregation of Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction, jointly termed familial Barrett's esophagus, may represent a complex genetic trait.
  • The aim of this study was to determine the proportion of patients with these diseases who have familial Barrett's esophagus.
  • METHODS: Information on gastroesophageal reflux symptoms, known risk factors for Barrett's esophagus, and family history of Barrett's esophagus and cancers, was collected at six hospitals using a structured questionnaire from probands with either long-segment Barrett's esophagus, adenocarcinoma of the esophagus, or adenocarcinoma of the gastroesophageal junction.
  • Family history of Barrett's esophagus or esophageal cancer in a first- or second-degree relative was determined by reviewing medical records of all relatives reported to be affected.
  • Upon review of medical records of the reportedly affected relatives, familial Barrett's esophagus was definitively determined in the case of 30 (7.3%) probands comprising 17 of 276 (6.2%) with Barrett's esophagus, 11 of 116 (9.5%) with adenocarcinoma of the esophagus, and 2 of 21 (9.5%) with adenocarcinoma of the gastroesophageal junction.
  • The diagnosis in the relative reported by the proband to be affected was found not to be Barrett's esophagus or adenocarcinoma in 15 (3.6%) cases.
  • The diagnosis could not be determined in 26 (6.3%) cases in which the proband reported an affected relative.
  • There were no significant differences in age of disease onset, gender, race, or gastroesophageal reflux symptoms between definitive familial Barrett's esophagus probands and nonfamilial probands.
  • CONCLUSION: Familial Barrett's esophagus can be confirmed in 7.3% of persons presenting with Barrett's esophagus, adenocarcinoma of the esophagus, or adenocarcinoma of the gastroesophageal junction.
  • [MeSH-major] Adenocarcinoma / genetics. Barrett Esophagus / genetics. Esophageal Neoplasms / genetics. Esophagogastric Junction

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  • (PMID = 16985029.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA30722; United States / NIDDK NIH HHS / DK / DK002800; United States / NIDDK NIH HHS / DK / DK061426; United States / NIDDK NIH HHS / DK / DK070863; United States / NIGMS NIH HHS / GM / GM28356; United States / PHS HHS / / P30CAD43703; United States / NCI NIH HHS / CA / R25 CA094186
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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