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Items 1 to 100 of about 1405
1. Seike K, Saito A, Mori Y: [A case of papillary cystadenoma of the epididymis]. Hinyokika Kiyo; 2007 Feb;53(2):137-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of papillary cystadenoma of the epididymis].
  • Computed tomographic demonstrated a left epididymal tumor in the hydrocele.
  • Microscopically, several microcysts were found and tumor cells showing a papillary growth pattern were found in these microcysts.
  • We finally diagnosed the patient as having papillary cystadenoma of the epididymis.
  • Papillary cystadenoma of the epididymis is rare epididymal benign tumor.
  • It is clinically important to determine whether or not the tumor is associated with von Hippel-Lindau disease.
  • [MeSH-major] Cystadenoma, Papillary / surgery. Epididymis. Genital Neoplasms, Male / surgery. Orchiectomy

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  • (PMID = 17352167.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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2. Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre JJ, Caprioli RM, Orgebin-Crist MC, Matusik RJ: Epididymis-specific lipocalin promoters. Asian J Androl; 2007 Jul;9(4):515-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymis-specific lipocalin promoters.
  • Our goal is to decipher which DNA sequences are required for tissue-specific expression of epididymal genes.
  • At least 6 epididymis-specific lipocalin genes are known.
  • These are differently regulated and regionalized in the epididymis.
  • Lipocalin 5 (Lcn5 or mE-RABP) and Lipocalin 8 (Lcn8 or mEP17) are homologous genes belonging to the epididymis-specific lipocalin gene cluster.
  • Both the 5 kb promoter fragment of the Lcn5 gene and the 5.3 kb promoter fragment of the Lcn8 gene can direct transgene expression in the epididymis (Lcn5 to the distal caput and Lcn8 to the initial segment), indicating that these promoter fragments contain important cis-regulatory element(s) for epididymis-specific gene expression.
  • To define further the fragments regulating gene expression, the Lcn5 promoter was examined in transgenic mice and immortalized epididymal cell lines.
  • Immunohistochemistry indicated a restricted expression of Foxa2 in the epididymis where endogenous Lcn5 gene expression is suppressed and that the Foxa2 inhibition of the Lcn5 promoter is consistent with the lack of expression of Lcn5 in the corpus and cauda.
  • Our approach provides a basic strategy for further analysis of the epididymal lipocalin gene regulation and flexible control of epididymal function.
  • [MeSH-major] Epididymis / physiology. Promoter Regions, Genetic

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  • (PMID = 17589789.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK55748; United States / NICHD NIH HHS / HD / HD36900
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / FOXA2 protein, human; 0 / LCN8 protein, human; 0 / Lcn5 protein, mouse; 0 / Lipocalins; 0 / Receptors, Retinoic Acid; 0 / Retinol-Binding Proteins, Plasma; 135845-92-0 / Hepatocyte Nuclear Factor 3-beta
  • [Number-of-references] 49
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3. Frenette G, Thabet M, Sullivan R: Polyol pathway in human epididymis and semen. J Androl; 2006 Mar-Apr;27(2):233-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polyol pathway in human epididymis and semen.
  • It has been previously shown that both enzymes are presented in the bovine epididymis, where they are associated with membranous vesicles called epididymosomes.
  • Based on the distribution of these enzymes, it has been hypothesized that the polyol pathway can modulate sperm motility during the epididymal transit.
  • In the present study, polyol pathway was investigated in semen and along the epididymis in humans in order to determine if sperm maturation can be associated with this sugar pathway.
  • Western blot, Northern blot, and reverse transcription-polymerase chain reaction analysis show that aldose reductase and sorbitol dehydrogenase are expressed at the transcriptional and translational levels along the human epididymis.
  • Immunohistological studies together with Western blot analysis performed on epididymosomes preparations indicate that the polyol pathway enzymes are secreted by the epididymal epithelium.
  • [MeSH-major] Epididymis / metabolism. Polymers / metabolism. Semen / metabolism

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  • (PMID = 16278369.001).
  • [ISSN] 0196-3635
  • [Journal-full-title] Journal of andrology
  • [ISO-abbreviation] J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polymers; 0 / polyol; 30237-26-4 / Fructose; 506T60A25R / Sorbitol; EC 1.1.1.14 / L-Iditol 2-Dehydrogenase; EC 1.1.1.21 / Aldehyde Reductase; IY9XDZ35W2 / Glucose
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4. Robaire B, Seenundun S, Hamzeh M, Lamour SA: Androgenic regulation of novel genes in the epididymis. Asian J Androl; 2007 Jul;9(4):545-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Androgenic regulation of novel genes in the epididymis.
  • The epididymis is critically dependent on the presence of the testis.
  • Although several hormones, such as retinoids and progestins, and factors secreted directly into the epididymal lumen, such as androgen binding protein and fibroblast growth factor, might play regulatory roles in epididymal function, testosterone (T) and its metabolites, dihydrotestosterone (DHT) and estradiol (E2), are accepted as the primary regulators of epididymal structure and functions, with the former playing the greater role.
  • To ascertain the molecular action of androgens on the epididymis, three complementary approaches were pursued to monitor changes in gene expression in response to different hormonal milieux.
  • The first was to establish changes in gene expression along the epididymis as androgenic support is withdrawn.
  • Together, these results provide novel insights into the mechanisms of androgen regulation in epididymal principal cells.
  • [MeSH-major] Androgens / physiology. Epididymis / physiology. Gene Expression Regulation

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  • (PMID = 17589794.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Androgens; 08J2K08A3Y / Dihydrotestosterone; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol
  • [Number-of-references] 79
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5. Odrzywolski KJ, Mukhopadhyay S: Papillary cystadenoma of the epididymis. Arch Pathol Lab Med; 2010 Apr;134(4):630-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary cystadenoma of the epididymis.
  • Papillary cystadenoma is a rare benign neoplasm of the epididymis, occurring mainly in young adult males.
  • Conversely, epididymal nodules presumed to be papillary cystadenomas are found in one-third of males with von Hippel-Lindau disease.
  • It originates in the efferent ductules of the head of the epididymis in the form of tiny precursor lesions.
  • [MeSH-major] Cystadenoma, Papillary / pathology. Epididymis. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Humans. Male. Middle Aged. Young Adult. von Hippel-Lindau Disease / diagnosis. von Hippel-Lindau Disease / genetics. von Hippel-Lindau Disease / pathology

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  • (PMID = 20367315.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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6. Aguilera-Merlo C, Muñoz E, Dominguez S, Scardapane L, Piezzi R: Epididymis of viscacha (Lagostomus maximus maximus): morphological changes during the annual reproductive cycle. Anat Rec A Discov Mol Cell Evol Biol; 2005 Jan;282(1):83-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymis of viscacha (Lagostomus maximus maximus): morphological changes during the annual reproductive cycle.
  • Little is known about morphological changes in the epididymis in relation to the natural photoperiod or their influence on sperm maturation.
  • In this work, we studied seasonal variations in the morphology and cellular population of the epididymis during both periods, and we compared these results with those recorded at the testicular level.
  • In the epididymal corpus, the number of clear cells increased, and the cytoplasm of principal cells showed numerous giant vacuoles.
  • In conclusion, the epididymis of the viscacha exhibits important seasonal morphological changes throughout annual reproductive cycle.
  • The epididymal corpus and cauda segments appeared to be the segments most sensitive to seasonal cyclical variations of the external environment.
  • We therefore postulate that the epididymal morphology of the viscacha probably could be regulated by the natural photoperiod.
  • [MeSH-major] Epididymis / anatomy & histology. Epididymis / physiology. Reproduction / physiology. Rodentia / physiology

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15622516.001).
  • [ISSN] 1552-4884
  • [Journal-full-title] The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
  • [ISO-abbreviation] Anat Rec A Discov Mol Cell Evol Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Turner TT: De Graaf's thread: the human epididymis. J Androl; 2008 May-Jun;29(3):237-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] De Graaf's thread: the human epididymis.
  • The epididymis consists of a single, highly coiled and convoluted tubule that Antoine De Graaf, the famous 17th-century anatomist, likened to a thread thickening to a string.
  • The regulation of that microenvironment and the manner by which it influences sperm maturation have been the topic of investigation for many years, though the study of the human epididymis directly is fraught with problems related to sample availability and condition.
  • The epididymal functions of transporting, concentrating, maturing, and storing sperm are important to male fertility and their absence or significant impairment can be a factor in male infertility.
  • [MeSH-major] Epididymis / anatomy & histology

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  • [ErratumIn] J Androl. 2008 Jul-Aug;29(4):468
  • (PMID = 18222912.001).
  • [ISSN] 1939-4640
  • [Journal-full-title] Journal of andrology
  • [ISO-abbreviation] J. Androl.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P50-DK45179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 118
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8. Jones RC, Dacheux JL, Nixon B, Ecroyd HW: Role of the epididymis in sperm competition. Asian J Androl; 2007 Jul;9(4):493-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of the epididymis in sperm competition.
  • In the context of the evolution of the mammalian epididymis, this report provides evidence that a major role of the epididymis is to enhance a male's chance of achieving paternity in a competitive mating system.
  • A unique example of sperm cooperation in monotremes is used as evidence that the epididymis produces sperm competition proteins to form groups of 100 sperm into bundles that have a forward motility nearly thrice that of individual spermatozoa.
  • It is suggested that variation between species in the intensity of sperm competition could explain the variation that occurs between species in the amount of post-testicular sperm maturation and storage in the epididymis, an explanation of why the human epididymis does not play as important a role in reproduction as the epididymis of most mammals.
  • [MeSH-major] Epididymis / physiology. Spermatozoa / physiology

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  • (PMID = 17589786.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 81
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9. Brisson P, Feins N, Patel H: Torsion of the epididymis. J Pediatr Surg; 2005 Nov;40(11):1795-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Torsion of the epididymis.
  • Anomalies of the epididymis are most commonly associated with an undescended testis but also found occasionally in a normally descended testis.
  • Painful symptoms required scrotal exploration with the finding of a torsion and infarction of the epididymis.
  • The etiology of the torsion was an abnormal attachment of the epididymis to the testis.
  • Torsion of the epididymis has not previously been reported.
  • [MeSH-major] Epididymis / pathology. Genital Diseases, Male / pathology

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  • (PMID = 16291173.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Talmon GA, Johannson SL: Serous cystadenoma of the epididymis. Urology; 2007 Aug;70(2):372.e7-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serous cystadenoma of the epididymis.
  • We present the first case of a serous cystadenoma of the epididymis in English reports with a brief literature review.
  • [MeSH-major] Cystadenoma, Serous / pathology. Epididymis. Genital Neoplasms, Male / pathology

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  • (PMID = 17826518.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 4
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11. Kamal BA: Basaloid carcinoma of epididymis. Urology; 2005 Jun;65(6):1227

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid carcinoma of epididymis.
  • A case of basaloid carcinoma of the right epididymis in a 22-year-old Saudi man is described.
  • The tumor presented as a painless swelling of 2 months' duration.
  • Microscopically, the stroma was widely infiltrated by tumor cells, with marked apoptosis and necrosis.
  • The tumor cells were rather uniform and basaloid and contained many abnormal mitoses.
  • The tumor was positive for keratin and contained tight intercellular junctions by ultrastructural examination.
  • The patient was tumor free at last follow-up.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Epididymis. Genital Neoplasms, Male / pathology

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  • (PMID = 15922440.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Lee JC, Bhatt S, Dogra VS: Imaging of the epididymis. Ultrasound Q; 2008 Mar;24(1):3-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of the epididymis.
  • High-transducer sonography allows the visualization of the epididymis and its detailed anatomy.
  • Features of benign and malignant epididymal lesions, including epididymal cysts, spermatoceles and tubular ectasia, sperm granulomas, adenomatoid tumors, leiomyomas, papillary cyst adenomas, lymphoma, and metastases are also presented.
  • In addition, epididymal trauma and torsion are discussed.
  • The goal of the review is to provide the radiologist with a better understanding of the numerous pathological conditions that occur in the epididymis.
  • [MeSH-major] Epididymis / ultrasonography. Genital Diseases, Male / ultrasonography. Ultrasonography, Doppler / methods

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  • (PMID = 18362528.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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13. Giannarini G, Scott CA, Moro U, Grossetti B, Pomara G, Selli C: Cystic endometriosis of the epididymis. Urology; 2006 Jul;68(1):203.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic endometriosis of the epididymis.
  • We present what we believe to be the first case of cystic endometriosis of the epididymis in a 27-year-old man with scrotal pain, describe its pathologic and immunohistochemical features, and discuss its pathogenesis.
  • [MeSH-major] Endometriosis. Epididymis. Genital Diseases, Male

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  • (PMID = 16808961.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Braun KP, Gastinger I, Theissig F, May M, Ernst H: [Rare tumor of the epididymis]. Internist (Berl); 2009 Aug;50(8):1022-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rare tumor of the epididymis].
  • A 51-year-old man with known ethyl toxic chronic pancreatitis presented with a tumor of the left epididymis.
  • Nevertheless a metastasis of a primary pancreatic carcinoma should be included in the differential diagnosis of a tumor of the paratesticular tissue.
  • The epididymis should be integrated in the diagnostic procedures of pancreatic carcinoma.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / secondary. Pancreatic Neoplasms / diagnosis. Testicular Neoplasms / diagnosis. Testicular Neoplasms / secondary
  • [MeSH-minor] Epididymis / pathology. Humans. Male. Middle Aged. Rare Diseases / diagnosis

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  • [Cites] Eur Urol. 1983;9(1):56-9 [6822245.001]
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  • (PMID = 19436976.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Schick B, Habermann F, Sinowatz F: Histochemical detection of glycoconjugates in the canine epididymis. Anat Histol Embryol; 2009 Apr;38(2):122-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histochemical detection of glycoconjugates in the canine epididymis.
  • A histochemical study using fluorescein isothiocyanate (FITC)-labelled lectins to identify glycoconjugates present in the efferent ductules and the three segments of the ductus epididymis (initial, middle and terminal segment) of dogs was carried out.
  • The lectin-binding pattern in the canine epididymis presents similarities and differences to those observed in other mammalian species.
  • The ductuli efferentes distinctly stained with most of the lectins used, whereas in the ductus epididymis a segment specific staining pattern was observed.
  • Whereas principal cells of the ductus epididymis stained clearly with several FITC-labelled lectins (WGA, UEA and PHA-L), basal cells showed only a significant binding of Con A.
  • [MeSH-major] Epididymis / chemistry. Glycoconjugates / analysis. Lectins / analysis

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  • (PMID = 19007355.001).
  • [ISSN] 1439-0264
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glycoconjugates; 0 / Lectins
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16. Ruiz-Argüelles GJ, Gómez-Almaguer D, Vela-Ojeda J, Morales-Toquero A, David-Gómez-Rangel J, García-Ruiz-Esparza MA, López-Martínez B, Cantú-Rodríguez OG, Gutiérrez-Aguirre CH: Extramedullary Leukemic Relapses Following Hematopoietic Stem Cell Transplantation with Nonmyeloablative Conditioning. Int J Hematol; 2005 Oct;82(3):262

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One patient had both subcutaneous nodules and epididymis EMR.

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  • (PMID = 28401517.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Allograft / Extramedullary / Leukemia / Nonmyeloablative / Relapse
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17. Al-Omar M, Kwan K, Tweedie E, Luke PP: Aggressive angiomyxoma of the epididymis. Can J Urol; 2005 Aug;12(4):2772-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive angiomyxoma of the epididymis.
  • Aggressive angiomyxoma is a rare locally invasive non-metastasizing soft tissue neoplasm that is most commonly located in the female pelvis and perineum.
  • We report a case of aggressive angiomyxoma arising from the epididymis of a young male, which was treated by radical orchiectomy.

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  • (PMID = 16197602.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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18. Gong DM, Li Z, Zhu XB, Liu YL, Cao XR, Liu Y, Wang YX: [Expression of OCTN2 mRNA in the human epididymis and its significance]. Zhonghua Nan Ke Xue; 2008 Mar;14(3):242-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of OCTN2 mRNA in the human epididymis and its significance].
  • OBJECTIVE: To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.
  • METHODS: We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.
  • RESULTS: OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.
  • CONCLUSION: The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation.
  • With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.
  • [MeSH-major] Epididymis / metabolism. Gene Expression Profiling. Organic Cation Transport Proteins / genetics

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  • (PMID = 18488339.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Cation Transport Proteins; 0 / RNA, Messenger; 0 / SLC22A5 protein, human
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19. Moyano Calvo JL, Giraldez Puig J, Sánchez de la Vega J, Dávalos Casanova G, Morales López A: [Adenomatoid tumor of the epididymis]. Actas Urol Esp; 2007 Apr;31(4):417-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis].
  • [Transliterated title] Tumor adenomatoide de epididimo.
  • Wa aport a new case of adenomatoid tumor of epididymis METHOD: Male of 40 years old with solid lesion in epidididymis tale treated with mass exéresis RESULTS: Adenoamotid tumor of the epididymis confirmed with hystopathologic technique CONCLUSION: Adenomatoid tumor of epididymis is the most frequent paratesticular tumors and when is suspected, conservative surgery must be performed.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 17633930.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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20. Al-Sayyad A, Cagiannos I: Fibrous pseudotumor of the epididymis and tunica vaginalis. Can J Urol; 2006 Oct;13(5):3279-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrous pseudotumor of the epididymis and tunica vaginalis.
  • We present a case of fibrous pseudotumor of the epididymis and tunica vaginalis which is one of the rarest paratesticular tumors.
  • Pathological examination is the only reliable way to make the diagnosis with these tumors exhibiting characteristic macroscopic and microscopic features.
  • [MeSH-major] Epididymis / pathology. Genital Neoplasms, Male / pathology. Neoplasms, Fibrous Tissue / pathology

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  • (PMID = 17076952.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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21. Robaire B, Henderson NA: Actions of 5alpha-reductase inhibitors on the epididymis. Mol Cell Endocrinol; 2006 May 16;250(1-2):190-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Actions of 5alpha-reductase inhibitors on the epididymis.
  • Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis.
  • DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa.
  • Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation.
  • [MeSH-major] 5-alpha Reductase Inhibitors. Cholestenone 5 alpha-Reductase / antagonists & inhibitors. Contraceptive Agents, Male / pharmacology. Enzyme Inhibitors / pharmacology. Epididymis / drug effects

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  • (PMID = 16476520.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / 4-(3-(3-(bis(4-isobutylphenyl)methylamino)benzoyl)-1H-indol-1-yl)butyric acid; 0 / 5-alpha Reductase Inhibitors; 0 / Androstenes; 0 / Azasteroids; 0 / Contraceptive Agents, Male; 0 / Enzyme Inhibitors; 0 / Indoles; 0 / Isoenzymes; 0 / PNU 157706; 0 / Phenylbutyrates; 08J2K08A3Y / Dihydrotestosterone; 57GNO57U7G / Finasteride; EC 1.3.1.22 / Cholestenone 5 alpha-Reductase; EC 1.3.99.5 / 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; O0J6XJN02I / Dutasteride
  • [Number-of-references] 60
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22. Zou M, Wang HF, Hu JM: [The application of proteomics in epididymis researches]. Sheng Li Ke Xue Jin Zhan; 2008 Apr;39(2):139-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The application of proteomics in epididymis researches].
  • Epididymis is responsible for the sperm maturation and storage, and its gene expression is highly region-specific, so it maybe an ideal model for proteomics, especially for differential proteomics study.
  • This paper gives a brief introduction of the application of proteomics in the epididymis and the differential proteins expressed in different epididymal regions.
  • These epididymis-specific/selective proteins identified by proteomics technology may prove to be targets for contraception or may provide insight to the unique responsibilities of the epididymis in supporting male fertility.
  • [MeSH-major] Epididymis / metabolism. Proteomics

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  • (PMID = 18664178.001).
  • [ISSN] 0559-7765
  • [Journal-full-title] Sheng li ke xue jin zhan [Progress in physiology]
  • [ISO-abbreviation] Sheng Li Ke Xue Jin Zhan
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
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23. Schön J, Blottner S: Seasonal variations in the epididymis of the roe deer (Capreolus capreolus). Anim Reprod Sci; 2009 Apr;111(2-4):344-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seasonal variations in the epididymis of the roe deer (Capreolus capreolus).
  • However, data regarding the seasonal variations taking place in the epididymis of the roe buck are not available.
  • Therefore, this study provides a detailed morphological description of the roe buck's epididymis (cell types and segments) and a qualitative as well as quantitative characterization of the seasonal changes in the different parts of the duct.
  • Seasonal changes in the cellular composition of the epididymis were studied by computer aided image analysis of histological preparations.
  • With regard to morphological criteria we defined 6 segments (S) within the epididymis (ductuli efferentes and S1-5) during the active period.
  • In the caput this enlargement of the duct is primarily caused by the growth of the epithelial compartment, whereas in the cauda it is predominantly attributed to the dilatation of the lumen, which is filled with testicular and epididymal fluid and spermatozoa towards the rut.
  • This leads to distinct changes in the tissue composition of samples taken from the three main regions of the epididymis at different times of the year.
  • This morphometric study provides the prerequisite for investigations of regulation mechanisms in epididymis function.
  • [MeSH-major] Deer / anatomy & histology. Epididymis / anatomy & histology

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  • (PMID = 18450392.001).
  • [ISSN] 1873-2232
  • [Journal-full-title] Animal reproduction science
  • [ISO-abbreviation] Anim. Reprod. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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24. Gregory M, Cyr DG: Identification of multiple claudins in the rat epididymis. Mol Reprod Dev; 2006 May;73(5):580-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of multiple claudins in the rat epididymis.
  • The luminal environment of the epididymis is highly specialized with specific proteins, ions, pH, etc. required for sperm maturation.
  • Tight junctions between epididymal principal cells are responsible for the formation of the blood-epididymal barrier, which regulates this luminal environment.
  • Previous work from our laboratory has demonstrated the presence and localization of Cldn-1 in all regions of the rat epididymis.
  • The objective of this study was to determine the presence and localization of other Cldns in the epididymis.
  • Using RT-PCR we have identified mRNA transcripts for Cldn-3 through -9 in each region of the adult rat epididymis.
  • Cldn-3 was localized apically in the epididymal epithelium between adjacent principal cells throughout the epididymis, where tight junctions have been reported histologically.
  • The immunostaining was more pronounced in the proximal regions of the epididymis.
  • In both 42-day-old rats and adults, Cldn-4 was localized primarily to apical tight junctions between principal cells and staining was more pronounced in the proximal region of the epididymis.
  • These transcripts were present in both proximal and distal regions of the epididymis of young (Day 14 and 21) animals, but only in the proximal (initial segment) region of the adult epididymis.
  • These data indicate that epididymal tight junctions are composed of several Cldns, suggestive of a complex regulation of the blood-epididymal barrier.
  • [MeSH-major] Aging / physiology. Blood-Testis Barrier / metabolism. Epididymis / metabolism. Gene Expression Regulation / physiology. Membrane Proteins / biosynthesis. Tight Junctions / metabolism

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  • [Copyright] Mol. Reprod. Dev. (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16489631.001).
  • [ISSN] 1040-452X
  • [Journal-full-title] Molecular reproduction and development
  • [ISO-abbreviation] Mol. Reprod. Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins
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25. Pila Pérez R, Rosales Torres P, Pila Peláez R, Holguín Prieto V, Torres Vargas E: [Adenomatoid tumor of the epididymis: an infrequent case]. Arch Esp Urol; 2009 Oct;62(8):656-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis: an infrequent case].
  • [Transliterated title] Tumor adenomatoide del epidídimo: una infrecuente observación.
  • OBJECTIVES: To present a new case of adenomatoid tumor of the epididymis, the first report in our hospital since 1962.
  • METHODS: We report a clinical case with a brief bibliographic review about adenomatoid tumor of the epididymis.
  • RESULTS: A 30-year-old man presented pain and inflammation in the left epididymis.
  • Physical examination and ultrasound study demonstrated a tumor of 5x5x2 cm.
  • It was removed and the histopathological study was compatible with adenomatoid tumor of the epididymis.
  • CONCLUSION: The adenomatoid tumor of the epididymis is a neoplasm located in the paratesticular region, however it can be found infrequently in other sites.
  • Physical examination and testicular ultrasound constituted important tools in the diagnosis.
  • It can minimally invade adjacent structures, though it is benign without metastatic potential.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 19893140.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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26. Baska KM, Manandhar G, Feng D, Agca Y, Tengowski MW, Sutovsky M, Yi YJ, Sutovsky P: Mechanism of extracellular ubiquitination in the mammalian epididymis. J Cell Physiol; 2008 Jun;215(3):684-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanism of extracellular ubiquitination in the mammalian epididymis.
  • While protein ubiquitination typically occurs in the cell cytosol or nucleus, defective mammalian spermatozoa become ubiquitinated on their surface during post-testicular sperm maturation in the epididymis, suggesting an active molecular mechanism for sperm quality control.
  • Consequently, we hypothesized that the bioactive constituents of ubiquitin-proteasome pathway were secreted in the mammalian epididymal fluid (EF) and capable of ubiquitinating extrinsic substrates.
  • Accumulation of eGFP, ubiquitin and proteasomes was detected in the apical blebs, the apocrine secretion sites of the caput epididymal epithelia of both the rat and mouse epididymal epithelium, although region-specific differences exist.
  • Secretion of eGFP and proteasomes continued during the prolonged culture of the isolated rat epididymal epithelial cells in vitro.
  • This study provides evidence that the activity of the ubiquitin system is not limited to the intracellular environment, contributing to a greater understanding of the sperm maturation process during epididymal passage.
  • [MeSH-major] Epididymis / metabolism. Extracellular Space / metabolism. Mammals / metabolism. Ubiquitination

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18064599.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media; 0 / Fluorescent Dyes; 0 / Sulfhydryl Compounds; 0 / Ubiquitin C; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 3.2.1.17 / Muramidase; EC 3.4.- / Endopeptidases; EC 3.4.25.1 / Proteasome Endopeptidase Complex; EC 6.3.2.19 / Ubiquitin-Protein Ligase Complexes
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27. Sostaric E, Aalberts M, Gadella BM, Stout TA: The roles of the epididymis and prostasomes in the attainment of fertilizing capacity by stallion sperm. Anim Reprod Sci; 2008 Sep;107(3-4):237-48

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The roles of the epididymis and prostasomes in the attainment of fertilizing capacity by stallion sperm.
  • The epididymis is a long, tightly coiled tube within the lumen of which sperm matures.
  • Sperm maturation involves morphological and biochemical changes in the sperm plasma membrane in response to epididymal secretions and their various proteins.
  • Nevertheless, the molecular pathways by which spermatozoa acquire fertilizing capacity during their transit through the epididymis remain ambiguous.
  • In a recent study of stallion epididymal sperm, we found that sperm harvested from different parts of the epididymis (caput, corpus and cauda) had a varying, but generally poor, ability to undergo the acrosome reaction in vitro.
  • Seminal plasma components may have a 'washing' effect and help to remove 'de-capacitation' factors that coat the sperm during storage in the cauda epididymis; alternatively seminal plasma and prostasomes may contain factors that more directly promote sperm activation.
  • This article reviews current information on the roles of epididymal and accessory gland fluids on the acquisition of fertilizing capacity by stallion sperm.
  • [MeSH-major] Epididymal Secretory Proteins / physiology. Epididymis / physiology. Fertilization / physiology. Horses / physiology. Sperm Capacitation / physiology

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  • (PMID = 18550301.001).
  • [ISSN] 0378-4320
  • [Journal-full-title] Animal reproduction science
  • [ISO-abbreviation] Anim. Reprod. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Epididymal Secretory Proteins; 0 / Membrane Proteins; 0 / Seminal Plasma Proteins
  • [Number-of-references] 78
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28. Fumo MJ, Assi OA, Liroff S: Leiomyoma of the epididymis treated with partial epididymectomy. Nat Clin Pract Urol; 2006 Sep;3(9):504-7; quiz 1 p following 507

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyoma of the epididymis treated with partial epididymectomy.
  • On physical examination, a firm mass measuring 2 cm x 2 cm and involving the inferior portion of the left epididymis was found.
  • The left testicle, right testicle, and right epididymis looked normal on examination.
  • INVESTIGATIONS: Assessment of tumor-marker levels, ultrasound examination of the scrotum, Doppler ultrasound examination, surgical exploration, and histologic examination of frozen sections.
  • DIAGNOSIS: Pure leiomyoma arising from the epididymis.
  • MANAGEMENT: Complete excision of the mass with its contiguous epididymis, preserving the left testicle and rest of the epididymis.
  • [MeSH-major] Epididymis / surgery. Genital Neoplasms, Male / surgery. Leiomyoma / surgery

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  • (PMID = 16964192.001).
  • [ISSN] 1743-4270
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Thibault F, Bart S, Rixe O, Comperat E, Renard R, Chartier-Kastler E, Richard F: [Primary carcinoma of the head of the epididymis]. Prog Urol; 2009 Jan;19(1):66-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary carcinoma of the head of the epididymis].
  • [Transliterated title] Tumeur épithéliale primitive de la tête de l'épididyme.
  • The authors report the case of a 44-year-old man in whom a poorly differentiated primary carcinoma of the head of the epididymis was discovered incidentally.
  • Due to the rarity of this diagnosis, a comprehensive assessment was performed looking for a primary tumour, but without success.
  • This exceptional tumour showed low sensitivity to chemotherapy.
  • Malignant tumours of the epididymis are exceptional and require investigations to detect a primary tumour.
  • [MeSH-major] Carcinoma. Epididymis. Genital Neoplasms, Male

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  • (PMID = 19135646.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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30. Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Azurmendi Arín I, Cantón Aller E, Pertusa Peña C: [Adenomatoid tumor of the epididymis. Report of five cases]. Arch Esp Urol; 2008 Sep;61(7):831-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis. Report of five cases].
  • [Transliterated title] Tumor adenomatoide epididimario. Aportación de 5 casos.
  • OBJECTIVE: Adenomatoid tumor of the epididymis is unfrequent, benign, with no malignant outcomes described.
  • METHODS: We report five cases, with patient's ages varying from 31 to 76 years, and tumor sizes from 6 to 30 mm.
  • Pathology confirmed the benign adenomatoid character in all cases.
  • CONCLUSIONS: Despite the clinical, ultrasound and physical examination findings suggest the localization in the epididymis and its benign character, surgical exploration is mandatory with surgical excision of the paratesticular mass.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 18972922.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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31. Beu CC, Orsi AM, Domeniconi RF: Structure of the lining epithelium of the cauda epididymis of the golden hamster. Anat Histol Embryol; 2009 Feb;38(1):49-57

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Structure of the lining epithelium of the cauda epididymis of the golden hamster.
  • The ductus epididymis has roles in the maturation and storage of spermatozoa.
  • The main function of the cauda epididymis is the storage of spermatozoa; however, this region exerts other morphophysiological roles.
  • So, this study was aimed at investigating structural features of the cauda epididymis epithelium, which could indicate roles other than the storage.
  • Moreover, transcytosis may occur at the cauda epididymis of Golden hamster.
  • [MeSH-major] Epididymis / ultrastructure. Mesocricetus / anatomy & histology. Seminiferous Epithelium / ultrastructure

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  • (PMID = 18983625.001).
  • [ISSN] 1439-0264
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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32. Cao SF, Xu C: [Specialized gene expression and regulation in the epididymis]. Zhonghua Nan Ke Xue; 2006 Jan;12(1):71-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Specialized gene expression and regulation in the epididymis].
  • The epididymis is a single and highly convoluted tubule system in mammals.
  • The epithelium is the major compartment for epididymal function.
  • Proteins synthesized and secreted by epididymal epithelium provide a special and ever-changing luminal fluid environment for sperm as they progress through the epididymis, which makes sperm achieve motility and ultimately results in sperm functional maturation.
  • Specialized genes expressed in the epididymis have regional-specific characteristics.
  • They are regulated by androgen and/or testicular factors and present spatial and tempel-specialized expression pattern in postnatal development, all these hint that they play important and unique roles in epididymis.
  • [MeSH-major] Epididymis / physiology. Gene Expression Regulation, Developmental. Sperm Maturation / genetics
  • [MeSH-minor] Animals. Epididymal Secretory Proteins / genetics. Male. Mammals

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  • (PMID = 16483167.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Epididymal Secretory Proteins
  • [Number-of-references] 21
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33. Liu CH, Jing QH, Ma B, Zhang AH, Ma YN, Peng GJ, Wang JW: [Sonographical features of the epididymis tuberculosis with caseous necrosis]. Zhonghua Nan Ke Xue; 2005 Dec;11(12):912-4, 917
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sonographical features of the epididymis tuberculosis with caseous necrosis].
  • OBJECTIVE: To analyse sonographical features of epididymis tuberculosis with caseous necrosis and improve the accuracy of ultrasonic diagnosis.
  • METHODS: Ultrasonic features of 12 cases with epididymis tuberculosis with caseous necrosis, confirmed by surgical pathology, was retrospectively analysed: size, location, echogenicity, degree of blood flow in the lesion.
  • The epididymal tuberculosis with caseous necrosis could present images of the whole or focal epididymal enlargement and abnormal shape.
  • CONCLUSION: The High Frequency Color Doppler images is helpful for the diagnosis and differential diagnosis of epididymis tuberculosis with caseous necrosis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Middle Aged. Necrosis. Retrospective Studies. Ultrasonography, Doppler, Color

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  • (PMID = 16398362.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Trybek G, Kolasa A, Marchlewicz M, Wenda-Rózewicka L, Wiszniewska B: Immunolocalization of androgen receptor in the epididymis of rats with dihydrotestosterone deficiency. Reprod Biol; 2005 Nov;5(3):291-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolocalization of androgen receptor in the epididymis of rats with dihydrotestosterone deficiency.
  • Dihydrotestosterone (DHT), 5alpha-reduced metabolite of testosterone, is the most potent androgen in the epididymis.
  • The activity of 5alpha-reductase type 2, preferentially expressed in the epididymis can be inhibited by a finasteride (a steroid-based specific inhibitor of 5alpha-reductase type 2) which results in DHT deficiency.
  • The aim of the study was to examine the morphology of epididymis and the immunolocalization of an androgen receptor (AR) in the initial segment, caput and cauda epididymis of rats treated with finasteride for 56 days.
  • There were no morphological changes in the morphology of epididymal epithelium in the experimental rats.
  • Immunostainable AR was localized in nuclei of epithelial cells, smooth muscle cells and mainly in the cytoplasm of interstitial cells in the epididymis of control rats.
  • In the epididymis of experimental rats, AR immunostaining was noticed mainly in the cytoplasm of epithelial cells and interstitial cells.
  • The single cells of the initial segment epithelium, basal cells and smooth muscle cells of cauda epididymis showed nuclear AR staining.
  • In conclusion, finasteride affected the expression of the AR in the rat epididymis without changing the morphology of epididymal epithelium.
  • Altered AR expression reflected the hormonal status within the epididymis.
  • [MeSH-major] Dihydrotestosterone / metabolism. Epididymis / metabolism. Finasteride / pharmacology. Receptors, Androgen / metabolism

  • Hazardous Substances Data Bank. FINASTERIDE .
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  • (PMID = 16372046.001).
  • [ISSN] 1642-431X
  • [Journal-full-title] Reproductive biology
  • [ISO-abbreviation] Reprod Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / 5-alpha Reductase Inhibitors; 0 / Receptors, Androgen; 08J2K08A3Y / Dihydrotestosterone; 57GNO57U7G / Finasteride
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35. Crowell RC, Kiessling AA: Endogenous retrovirus expression in testis and epididymis. Biochem Soc Trans; 2007 Jun;35(Pt 3):629-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endogenous retrovirus expression in testis and epididymis.
  • Work in this laboratory revealed remarkably high ERV expression in mouse epididymis, but not in testis.
  • Similar early studies revealed expression of human ERV-E4.1 in both testis and epididymis, but expression of other HERVs (human ERVs) was not examined.
  • Using degenerate primers to conserved regions of reverse transcriptase specific for each of nine HERV families, we have detected expression of six HERV families in epididymis and three in testis.
  • Differential HERV expression may reflect the fully differentiated state of epididymal epithelium in contrast with the immature germ cell population in the testis.
  • [MeSH-major] Endogenous Retroviruses / genetics. Epididymis / virology. Testis / virology

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  • (PMID = 17511667.001).
  • [ISSN] 0300-5127
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK52761; United States / NICHD NIH HHS / HD / HD21890
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
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36. Ozturk U, Kefeli M, Asci R, Akpolat I, Buyukalpelli R, Sarikaya S: The effects of experimental left varicocele on the epididymis. Syst Biol Reprod Med; 2008 Jul-Aug;54(4-5):177-84
MedlinePlus Health Information. consumer health - Male Infertility.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effects of experimental left varicocele on the epididymis.
  • It is obvious that varicocele would affect the morphology and function of the epididymis which is an intrascrotal organ.
  • In this study, the effects of experimental left varicocele (ELV) on the epididymal morphology were investigated in adult rats.
  • Epididymides were weighed; tubular diameters of the caput, corpus, and cauda of the epididymis were measured.
  • The TUNEL assay was used to assess apoptosis within the epididymal tubules.
  • The mean weight of each right and left epididymis in the varicocele group was lower than that in the control and sham groups (p < 0.01).
  • In the varicocele group, the left epididymis weighted less than the right by the end of the second month (p < 0.01).
  • Apoptosis was significantly increased in principal cells of the epididymal epithelium in the varicocele groups.
  • The apoptotic cells in the caput epididymis epithelium were more numerous than those in the other segments.
  • In conclusion, ELV significantly decreases epididymal weight and tubular diameters presenting increased apoptosis within the principal cells.
  • There is a positive correlation between the epididymal damage and the duration of varicocele.
  • [MeSH-major] Apoptosis. Epididymis / pathology. Infertility, Male / diagnosis. Varicocele / complications

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  • (PMID = 18942025.001).
  • [ISSN] 1939-6376
  • [Journal-full-title] Systems biology in reproductive medicine
  • [ISO-abbreviation] Syst Biol Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Garrido Abad P, Jiménez Gálvez M, Herranz Fernández LM, Bocardo Fajardo G, Arellano Gañán R, Pereira Sanz I: [Adenomatoid tumor of the epididymis. Report of two cases]. Arch Esp Urol; 2007 Jul-Aug;60(6):700-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis. Report of two cases].
  • [Transliterated title] Tumor adenomatoide de epidídimo. Aportación de dos casos.
  • OBJECTIVE: Tumors of the epididymis are rare.
  • They are unusually benign and adenomatoid tumors are the most frequent.
  • Report of two cases of this kind of tumor of the epididymis.
  • METHODS/RESULTS: We report two cases of adenomatoid tumor of the epididymis diagnosed at our hospital during last year.
  • Imaging techniques revealed a solid epididymal mass.
  • Pathological diagnosis was adenomatoid tumor.
  • CONCLUSIONS: The majority of epididymal tumors follow a benign course.
  • In the finding of an epididymal mass, after palpation and imaging tests, organ sparing surgery (epididymectomy) is recommended.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 17847749.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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38. Yang DM, Kim HC, Jin W, Lee HL, Kim GY: Lymphoma of the testis and epididymis mimics chronic inflammation upon sonography. J Clin Ultrasound; 2009 May;37(4):242-4
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphoma of the testis and epididymis mimics chronic inflammation upon sonography.
  • Scrotal gray-scale sonography revealed an irregularly margined, hypoechoic mass in the right testis and epididymis.
  • Color Doppler sonography showed increased blood flow within the hypoechoic lesions in both testis and epididymis.
  • Pathologic examination revealed a diffuse involvement of the testis and epididymis.
  • [MeSH-major] Epididymis / ultrasonography. Epididymitis / ultrasonography. Lymphoma / pathology. Orchitis / ultrasonography. Testicular Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Biopsy, Needle. Chronic Disease. Diagnosis, Differential. Genital Neoplasms, Male / pathology. Genital Neoplasms, Male / ultrasonography. Humans. Immunohistochemistry. Male. Risk Assessment. Ultrasonography, Doppler, Color

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  • (PMID = 18972362.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Maróstica E, Avellar MC, Porto CS: Effects of testosterone on muscarinic acetylcholine receptors in the rat epididymis. Life Sci; 2005 Jun 24;77(6):656-69
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of testosterone on muscarinic acetylcholine receptors in the rat epididymis.
  • The effect of testosterone on the expression of muscarinic acetylcholine receptor (mAChR) subtypes was studied in the rat epididymis, at mRNA and protein level.
  • The rat androgen status was monitored by measuring plasma testosterone level and caput and cauda epididymis wet weight.
  • Ribonuclease protection assay (RPA) and [3H]quinuclidinyl benzilate ([3H]QNB) binding assay were performed in the caput and cauda epididymis from control (50-day old), castrated, castrated and treated with testosterone and sexually immature (30-day old) rats.
  • The expression of each mAChR transcript subtype differed depending on the epididymal region analyzed and rat testosterone and/or testicular factors status.
  • In control rats, RPA showed the presence of mRNA for M1, M2 and M3 mAChR in the caput and cauda epididymis.
  • The abundance of m2 and m3 transcripts in the cauda was higher than that in the caput epididymis.
  • Orchidectomy increased m1 mRNA amount in the caput and cauda epididymis when compared to control rats, an effect slightly modified by testosterone replacement.
  • Although orchidectomy down-regulated the level of m2 transcript in both epididymal regions, castration significantly increased m3 mRNA amount in the caput region.
  • Similar abundance of m3 transcript, however, was detected in the cauda epididymis of all experimental group tested.
  • [3H]QNB binding studies revealed that orchidectomy down-regulated the number of mAChR detected in both epididymal regions, an effect also prevented by testosterone replacement.
  • Thus, testosterone and/or testicular factors may play a role in the regulation of mAChR expression in the rat epididymis.
  • [MeSH-major] Epididymis / metabolism. Receptors, Muscarinic / metabolism. Testosterone / physiology

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  • (PMID = 15921997.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Muscarinic; 3XMK78S47O / Testosterone
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40. Yoon SI, Park CJ, Nah WH, Gye MC: Expression of occludin in testis and epididymis of wild rabbits, Lepus sinensis coreanus. Reprod Domest Anim; 2009 Oct;44(5):745-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of occludin in testis and epididymis of wild rabbits, Lepus sinensis coreanus.
  • Tight junctions (TJs) in inter-Sertoli junctional areas and epididymal epithelia build up the blood-testis barrier (BTB) and the blood-epididymal barrier (BEB), respectively.
  • In this study, the expression of occludin, an integral member of the TJs, was examined in testis and different regions of epididymis of Lepus sinensis coreanus, an Korean wild rabbit species.
  • In proximal and distal caput epididymis, occludin immunoreactivity was found in the lateral as well as apical contacts of epithelial cells.
  • In corpus epididymis, intense occludin immunoreactivity was found in the basolateral as well as apical contacts of epithelial cells together with cytoplasmic signal.
  • In cauda epididymis, occludin immunoreactivity in luminal epithelia was relatively strong but largely found in the cytoplasm.
  • This suggests that intriguing regulatory mechanisms differentially recruit occludin to the TJ in the different regions of epididymal epithelia.
  • The differences in the subcellular localization as well as expression levels of occludin among the epididymal segments may reflect differential paracellular permeability of epithelia along the epididymal tubules and be correlated with sperm maturation in rabbit.
  • In Western blot, a major form of occludin was MW 62 kDa together with small fragments of MW 34-39 kDa in testis and epididymis, suggesting the peptide cleavage of occludin.
  • This is the first report on the molecular nature of TJs in a wild rabbit testis and epididymis.
  • [MeSH-major] Epididymis / chemistry. Hares / metabolism. Membrane Proteins / analysis. Testis / chemistry

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  • (PMID = 18992101.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Occludin
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41. Kim H, Kang TY, Joo HG, Shin T: Immunohistochemical localization of galectin-3 in boar testis and epididymis. Acta Histochem; 2006;108(6):481-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical localization of galectin-3 in boar testis and epididymis.
  • The presence and distribution of galectin-3, a beta-galactoside-binding protein, in boar testis and epididymis was studied.
  • Western blot analysis detected galectin-3 in boar testis and epididymis.
  • In particular, intense galectin-3 immunoreaction was seen in the tail of the epididymis, while it was moderate in the head and body.
  • In the epididymis, the galectin-3 immunoreactivity in the connective tissues was the same as in the testis.
  • Intense galectin-3 immunolabelling was seen in the covering epithelium of the epididymis tail, but in very few cells in the head and body.
  • Furthermore, we postulate that intracellular galectin-3 in the epithelium of the epididymis tail plays a role in either the maintenance of the epithelium or as a source of galectin-3 in the seminal fluid; here it may play a role in sperm activation in the boar reproductive system.
  • [MeSH-minor] Animals. Epididymis / cytology. Epididymis / metabolism. Immunohistochemistry / methods. Male. Semen / metabolism. Sperm Capacitation / physiology. Swine

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  • (PMID = 17084885.001).
  • [ISSN] 0065-1281
  • [Journal-full-title] Acta histochemica
  • [ISO-abbreviation] Acta Histochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Galectin 3
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42. Queiróz DB, Porto CS, Grossman G, Petrusz P, Avellar MC: Immunolocalization of alpha(1A)-adrenoceptors in rat and human epididymis. Cell Tissue Res; 2008 Jun;332(3):509-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolocalization of alpha(1A)-adrenoceptors in rat and human epididymis.
  • Immunohistochemistry was conducted to analyze the cellular localization of alpha(1A)-adrenoceptors along rat and human epididymis.
  • ADR-A, a polyclonal antibody that recognizes the specific C-terminal region of alpha(1A)-adrenoceptors, immunostained this adrenoceptor subtype in smooth muscle cells surrounding the epididymal tubules and interstitial blood vessels and in subpopulations of epithelial cells from adult rat and human caput and cauda epididymidis.
  • This is the first report immunolocalizing alpha(1A)-adrenoceptor along rat and human epididymis.
  • The presence of this adrenoceptor subtype in epididymal smooth muscle and epithelial cells indicates their contribution to smooth muscle contractile responses and a possible role in the absorptive and/or secretory activities of the epithelium lining the epididymal duct.
  • [MeSH-major] Epididymis / chemistry. Receptors, Adrenergic, alpha-1 / analysis

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  • (PMID = 18351393.001).
  • [ISSN] 0302-766X
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / D43 TW/HD 00627; United States / FIC NIH HHS / TW / R03 TW 001234; United States / NICHD NIH HHS / HD / U54 HD 35041
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / ADRA1A protein, human; 0 / Adra1a protein, rat; 0 / Receptors, Adrenergic, alpha-1
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43. Dahia CL, Rao AJ: Demonstration of follicle-stimulating hormone receptor in cauda epididymis of rat. Biol Reprod; 2006 Jul;75(1):98-106
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  • [Title] Demonstration of follicle-stimulating hormone receptor in cauda epididymis of rat.
  • In one of our studies that consisted of deprival of endogenous FSH in immature rats and adult bonnet monkeys, atrophy of the epididymis was observed, cauda region being the most affected.
  • Although epididymis is an androgen-dependent tissue, the changes in histology of the cauda region were observed without any associated change in the levels of testosterone in FSH-deprived animals.
  • Considering this, it was of interest to evaluate the possibility of epididymis being a direct target for FSH action.
  • In the present study, we have examined the expression of FSH receptor in the epididymis of rat and monkey.
  • In the cauda region of rat epididymis, FSH receptor expression was demonstrated by RT-PCR and Northern and Western blot analyses.
  • These results suggest the possibility of a role for FSH in regulating the growth of the epididymis.
  • [MeSH-major] Epididymis / chemistry. Receptors, FSH / analysis

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 16598027.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, FSH; 3XMK78S47O / Testosterone; 9002-68-0 / Follicle Stimulating Hormone; E0399OZS9N / Cyclic AMP
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44. Ch Tsili A, Tsampoulas C, Giannakopoulos X, Batistatou A, Arkoumani E, Silakos A, Sofikitis N, Efremidis SC: Solitary fibrous tumour of the epididymis: MRI features. Br J Radiol; 2005 Jun;78(930):565-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumour of the epididymis: MRI features.
  • We present a case of a solitary fibrous tumour, located at the epididymis, in a 65-year-old man, presented with a scrotal mass.
  • Ultrasound and MRI of the scrotum revealed a paratesticular mass, with rich vascularity, arising in the left epididymis.
  • [MeSH-major] Epididymis. Mesothelioma / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 15900066.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Nussbaum Blask AR, Rushton HG: Sonographic appearance of the epididymis in pediatric testicular torsion. AJR Am J Roentgenol; 2006 Dec;187(6):1627-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonographic appearance of the epididymis in pediatric testicular torsion.
  • OBJECTIVE: The purpose of this study was to determine the frequency of an enlarged epididymis in pediatric patients with testicular torsion and to determine whether an altered epididymis might be a helpful ancillary sonographic sign of testicular torsion.
  • MATERIALS AND METHODS: The sonograms of 50 pediatric patients (age range, neonate-17 years) with testicular torsion were retrospectively reviewed for the size, appearance, and blood flow of the epididymis.
  • RESULTS: The epididymis was enlarged (maximum dimension, 5.5 cm) in 47 of the 50 patients with acute or late phase torsion and after manual or spontaneous detorsion.
  • The average difference in volume between the ipsilateral epididymis and the contralateral epididymis was 30 cm3, highly significant (p < 0.0001).
  • The shape of the epididymis was altered in 92% of the cases (globular, bilobular, or multilobular).
  • In patients with testicular loss due to infarction, pathology showed engorgement and enlargement of the epididymis with hemorrhagic infarction.
  • In one patient with a hypervascular epididymis, surgery showed inflammation and erythema of the epididymis.
  • Testicular loss occurred in each type of epididymal flow pattern.
  • CONCLUSION: A markedly enlarged, echogenic, and avascular or hypovascular epididymis is an ancillary sonographic sign in pediatric patients with testicular torsion.
  • A hypervascular enlarged epididymis infrequently occurs (5% of cases) and should not be mistaken for epididymitis.
  • In addition, the return of epididymal blood flow is an ancillary sign of successful testicular detorsion.
  • [MeSH-major] Epididymis / ultrasonography. Spermatic Cord Torsion / ultrasonography

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  • [CommentIn] AJR Am J Roentgenol. 2008 Jan;190(1):W74 [18094277.001]
  • (PMID = 17114561.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Thimon V, Koukoui O, Calvo E, Sullivan R: Region-specific gene expression profiling along the human epididymis. Mol Hum Reprod; 2007 Oct;13(10):691-704

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Region-specific gene expression profiling along the human epididymis.
  • During their transit through the epididymis, spermatozoa undergo many biochemical modifications necessary to acquire flagellar motility and fertilizing ability.
  • These modifications, collectively called sperm maturation, are well orchestrated along the epididymis and depend on highly regionalized gene expression patterns.
  • Based on clinical observations, the role of the epididymis in human sperm maturation has been questioned.
  • More than 50% of transcripts were detected in each epididymal region.
  • The expressed qualifers were grouped according their similarity by Gene Ontology to give an overview of the functional features of the encoded proteins and to elucidate their potential roles in the epididymis.
  • Northern blot analysis of eight gene transcripts predicted by microarray data to be highly expressed in the human epididymis was performed.
  • The data generated in this study demonstrate a region-specific gene expression pattern along the human epididymis that seems to coincide with the morphologically distinctive features of the excurrent duct.
  • [MeSH-major] Epididymis / metabolism. Gene Expression Profiling / methods

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  • (PMID = 17881722.001).
  • [ISSN] 1360-9947
  • [Journal-full-title] Molecular human reproduction
  • [ISO-abbreviation] Mol. Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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47. Cao LT, Yang ZW, Gu P, Zhang MH, Zhang Q, Deng XZ, Wang JZ: [Ultrasonographic changes in the epididymis after long-term vasectomy]. Zhonghua Nan Ke Xue; 2007 Mar;13(3):212-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ultrasonographic changes in the epididymis after long-term vasectomy].
  • OBJECTIVE: To evaluate the ultrasonographic changes in the epididymis after long-term vasectomy.
  • The patients were referred to scrotal ultrasonography for epididymal indications.
  • The shape, thickness and internal echoes of the head, body and tail of the epididymis were observed with high frequency ultrasonography (HFU), and the blood flow changes were observed with color Doppler flow imaging (CDFI) or color Doppler power imaging (CDPI).
  • RESULTS: Significantly higher rates were found in the vasectomy group than in the control: thickened body (64.1% vs 15.0%) and tail (78.1% vs 51.7%) of the epididymis, thickened head, body and tail (42.2% vs 8.3%) of the epididymis, and epididymal tubular ectasia (54.7% vs 8.3%).
  • However, increased blood flow in the epididymis was seen at a significantly lower rate in the vasectomy group than in the control (15.6% vs 61.7%).
  • CONCLUSION: The ultrasonographic changes in the epididymis after long-term vasectomy were mainly epididymis thickening and epididymal tubular ectasia, mostly with no or diminished blood flow in the epididymis.
  • [MeSH-major] Epididymis / ultrasonography. Vasectomy

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  • (PMID = 17393781.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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48. Prabagaran E, Hegde UC, Moodbidri SB, Bandivdekar AH, Raghavan VP: Postnatal expression and androgen regulation of HOXBES2 homeoprotein in rat epididymis. J Androl; 2007 Sep-Oct;28(5):755-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postnatal expression and androgen regulation of HOXBES2 homeoprotein in rat epididymis.
  • The multifunctional and androgen-regulated epididymis is known to provide a conducive microenvironment for the maturation and storage of mature spermatozoa.
  • HOXB2 homeodomain-containing epididymis-specific sperm protein (HOXBES2), a molecule first reported by our group, exhibits cell- and region-specific expression.
  • It was found in the cytoplasm of the principal epithelial cells with maximum in the distal segments of the rat epididymis.
  • The present study was undertaken to determine whether HOXBES2 expression is regulated by androgens and postnatal epididymal development.
  • Toward this, the epididymis was disallowed access to circulating androgens either by chemical or biologic castration.
  • Ethylene dimethane sulfonate (EDS) administration completely abolished HOXBES2 expression in the epididymis, and supplementation with DHT or DHT + estradiol for 10 days re-established HOXBES2 expression to near normalcy.
  • During postnatal development, protein expression in the epididymis begins to appear from day 40 and 50 and increased from day 60 onward, coinciding with the mature levels of circulating androgens and the well-differentiated epididymis.
  • Thus, the data obtained from this study suggests that HOXBES2 expression could be regulated by androgens, and its expression level is closely associated with the postnatal development of the epididymis.
  • [MeSH-major] Androgens / metabolism. Epididymis / metabolism. Homeodomain Proteins / metabolism. Testis / metabolism

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  • (PMID = 17494099.001).
  • [ISSN] 0196-3635
  • [Journal-full-title] Journal of andrology
  • [ISO-abbreviation] J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / HOXBES2 protein, rat; 0 / Homeodomain Proteins; 0 / Mesylates; 4672-49-5 / ethylene dimethanesulfonate
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49. Oh J, Lee J, Woo JM, Choi E, Park I, Han C, Baek N, Lee H, Kim DH, Cho C: Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis. BMC Genomics; 2006;7:314

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis.
  • BACKGROUND: Maturation of spermatozoa, including development of motility and the ability to fertilize the oocyte, occurs during transit through the microenvironment of the epididymis.
  • Comprehensive understanding of sperm maturation requires identification and characterization of unique genes expressed in the epididymis.
  • RESULTS: We systematically identified 32 novel genes with epididymis-specific or -predominant expression in the mouse epididymis UniGene library, containing 1505 gene-oriented transcript clusters, by in silico and in vitro analyses.
  • A number of the novel genes are putative epididymal protease inhibitors or beta-defensins.
  • CONCLUSION: We identified and characterized 32 novel epididymis-specific or -predominant genes by an integrative approach.
  • Our study is unique in the aspect of systematic identification of novel epididymal genes and should be a firm basis for future investigation into molecular mechanisms underlying sperm maturation in the epididymis.
  • [MeSH-major] Epididymis / physiology. Gene Expression Regulation

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  • (PMID = 17166261.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary
  • [Other-IDs] NLM/ PMC1764739
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50. Britan A, Maffre V, Tone S, Drevet JR: Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis. Cell Tissue Res; 2006 May;324(2):301-10
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  • [Title] Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis.
  • Previous reports have suggested that indoleamine 2,3-dioxygenase (IDO) activity is particularly important in mouse epididymis tissue.
  • We show here, using reverse transcription/polymerase chain reaction assays, Northern assays, Western blotting experiments, and immunohistochemistry that IDO is indeed highly expressed in mouse epididymis, and that IDO mRNA distribution and protein location are precisely regionalized within the organ and within sub-territories of the proximal part of the epididymal duct, the so-called caput epididymidis.
  • On the contrary, tryptophan dioxygenase (TDO), a sister enzyme of IDO, is weakly and uniformly expressed in mouse epididymis and, in contrast to IDO, is also expressed in testis.
  • In the epididymis, TDO protein expression has been found in a totally different cell type in the smooth muscle layer surrounding the epididymal tubules.
  • Finally, IDO is not secreted into the epididymal lumen, whereas the testis-expressed TDO is present on the head of spermatozoa retrieved from the cauda epididymidis.
  • On the basis of the various functions that have been associated with IDO/TDO, we discuss the putative impacts of IDO/TDO expression on the physiology of mammalian epididymis and spermatozoa.
  • [MeSH-major] Epididymis / enzymology. Indoleamine-Pyrrole 2,3,-Dioxygenase / genetics. Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism. Tryptophan / metabolism. Tryptophan Oxygenase / genetics. Tryptophan Oxygenase / metabolism

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  • (PMID = 16450123.001).
  • [ISSN] 0302-766X
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Indoleamine-Pyrrole 2,3,-Dioxygenase; 0 / RNA, Messenger; 8DUH1N11BX / Tryptophan; EC 1.13.11.11 / Tryptophan Oxygenase
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51. Zhang JS, Liu Q, Li YM, Hall SH, French FS, Zhang YL: Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray. Mol Cell Endocrinol; 2006 May 16;250(1-2):169-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray.
  • Sperm maturation during passage through the epididymis depends on regionalized gene expression which maintains the progressively changing environment within the epididymal tubule.
  • Towards defining the genes that drive the sequential maturation of spermatozoa, we profiled regionally regulated gene expression pattern in the epididymis of a fertile young male donor using Affymetrix human genome U133 plus 2.0 microarray representing approximately the whole human genome.
  • Over 15000 transcripts, almost one-third of the total on the array were identified in whole epididymis.
  • Among them, 65% were detected in all three regions of the epididymis, 410 or 2.6% were present only in one region and the remaining 32.4% were distributed in two regions.
  • This study revealed for the first time, the expression in human epididymis of a number of region-specific genes.
  • [MeSH-major] Epididymis / metabolism. Gene Expression Profiling. Gene Expression Regulation, Developmental. Genome, Human / genetics. Sperm Maturation / genetics

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  • (PMID = 16412555.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Grant] United States / FIC NIH HHS / TW / 1R03TW01490
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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52. França LR, Avelar GF, Almeida FF: Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs. Theriogenology; 2005 Jan 15;63(2):300-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs.
  • The sperm transit through the epididymis takes approximately 10 days in pigs and this is within the range cited for most mammals.
  • [MeSH-major] Epididymis / cytology. Spermatogenesis. Swine

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  • (PMID = 15626401.001).
  • [ISSN] 0093-691X
  • [Journal-full-title] Theriogenology
  • [ISO-abbreviation] Theriogenology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 112
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53. Verma RJ, Nair A, Mathuria N: Vitamin E ameliorates aflatoxin-induced alterations in the epididymis of mice. Acta Pol Pharm; 2008 May-Jun;65(3):331-7
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  • [Title] Vitamin E ameliorates aflatoxin-induced alterations in the epididymis of mice.
  • The present investigation was an attempt to evaluate the effect of aflatoxin on biochemical and histopathological changes in the epididymis of mice and its possible amelioration on pre-treatment with vitamin E.
  • Epididymis was isolated and processed for biochemical analysis.
  • As compared with the control, absolute and relative epididymal weights were significantly reduced in aflatoxin-treated mice.
  • Aflatoxin treatment caused significant, dose-dependent reduction in protein and sialic acid contents in caput and cauda epididymis than that of vehicle control.
  • While activities of succinic dehydrogenase and adenosine triphosphatase were significantly reduced, acid phosphatase activity was significantly higher in caput and cauda epididymis of aflatoxin-treated mice than that of vehicle control.
  • Pyknosis of epithelial cell nuclei, disorganization of epithelium, clumping of stereocilia and lumen devoid of sperms in caput and cauda epididymis were observed.
  • [MeSH-major] Aflatoxins / toxicity. Antioxidants / pharmacology. Epididymis / drug effects. Vitamin E / pharmacology

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  • (PMID = 18646552.001).
  • [ISSN] 0001-6837
  • [Journal-full-title] Acta poloniae pharmaceutica
  • [ISO-abbreviation] Acta Pol Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Aflatoxins; 0 / Antioxidants; 0 / Proteins; 1406-18-4 / Vitamin E; EC 1.3.99.1 / Succinate Dehydrogenase; EC 3.1.3.2 / Acid Phosphatase; EC 3.6.1.- / Adenosine Triphosphatases; GZP2782OP0 / N-Acetylneuraminic Acid
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54. Bestard Vallejo JE, Tremps Velázquez E, Blázquez Mañá C, Celma Doménech A, de Torres Ramírez I, Morote Robles J: [Adenomatoid tumour of epididymis: the most common tumour of the paratesticular structures]. Actas Urol Esp; 2008 Jun;32(6):611-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumour of epididymis: the most common tumour of the paratesticular structures].
  • [Transliterated title] Tumor adenomatoide de epididimo: el tumor más frecuente de las estructuras paratesticulares.
  • INTRODUCTION: Paratesticular tumours are rare but generally benign neoplasms, usually treated by local excission.
  • Adenomatoid tumours of epididymis are the most common of these tumours.
  • OBJECTIVES: Analyze paratesticular tumours treated in our center and describe dyagnosis and treatment of adenomatoid tumours of epididymis.
  • RESULTS: Patients median age was 44.1 years (22-69), presenting most of them subacute scrotal tumour with median size by ultrasound of 2.8 cm (1.5-7).
  • Dyagnosis was in 4 cases adenomatoid tumour of epididymis, in two cases fibrous pseudotumour of epididymis, in one case leiomyoma of epididymis and in one case angiolipoma of spermatic cord.
  • Just in one case diagnosed of adenomatoid tumour of epididymis ultrasound confirmed solid tumour suggesting the final dyagnosis.
  • CONCLUSIONS: Adenomatoid tumors of epididymis are rare tumours which may present at any age.
  • Benignity of adenomatoid tumour of epididymis as well as most of the other paratesticular tumours should make local excission the treatment of choice and, when any doubt existed, peroperatory biopsy should be performed.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 18655344.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 19
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55. Kwon J, Sekiguchi S, Wang YL, Setsuie R, Yoshikawa Y, Wada K: The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis. Exp Anim; 2006 Jan;55(1):35-43
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  • [Title] The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis.
  • We previously showed that gad mice, which are deficient for ubiquitin C-terminal hydrolase L1 (UCH-L1), have a significantly increased number of defective spermatozoa, suggesting that UCH-L1 functions in sperm quality control during epididymal maturation.
  • The epididymis is the site of spermatozoa maturation, transport and storage.
  • Region-specific functions along the epididymis are essential for establishing the environment required for sperm maturation.
  • We analyzed the region-specific expression of UCH-L1 and UCH-L3 along the epididymis, and also assessed the levels of ubiquitin, which has specificity for UCH-L1.
  • In wild-type mice, western blot analysis demonstrated a high level of UCH-L1 expression in the caput epididymis, consistent with ubiquitin expression, whereas UCH-L3 expression was high in the cauda epididymis.
  • We also investigated the function of UCH-L1 and UCH-L3 in epididymal apoptosis induced by efferent duct ligation.
  • In conclusion, the response of gad and Uchl3 knockout mice to androgen withdrawal suggests a reciprocal function of the two UCH enzymes in the caput epididymis.

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  • (PMID = 16508210.001).
  • [ISSN] 1341-1357
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Ubiquitin; EC 3.1.2.15 / Ubiquitin Thiolesterase; EC 3.1.2.15 / Ubiquitin carboxyl-Terminal Hydrolase L-1, mouse
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56. Kim H, Ahn M, Moon C, Kim S, Jee Y, Joo HG, Shin T: Immunohistochemical study of galectin-3 in mature and immature bull testis and epididymis. J Vet Sci; 2008 Dec;9(4):339-44
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  • [Title] Immunohistochemical study of galectin-3 in mature and immature bull testis and epididymis.
  • We examined galectin-3 expression in the testis and epididymis of sexually mature and immature bulls.
  • Western blot analysis showed varying levels of galectin-3 in the bull testis and epididymis, and galectin-3 immunoreactivity was higher in the mature testis and epididymis than in immature organs.
  • In the immature epididymis head, galectin-3 was primarily in the principal and basal cells of the epithelium.
  • In the mature epididymis head, moderate levels of galectin-3 were detected in the sperm, while low levels were found in the stereocilia, epithelium and connective tissue.
  • In the immature epididymis body, moderate protein levels were detected in the principal cells, while lower levels were found in the basal cells.
  • The mature epididymis body showed moderate levels of galectin-3 immunostaining in the stereocilia and epithelium, but low levels in the connective tissue.
  • In the immature epididymis tail, only low levels of galectin-3 staining were found in the epithelium, whereas the mature epididymis tail showed high levels of galectin-3 in the principal cells, moderate levels in the basal cells and low levels in connective tissue.
  • [MeSH-major] Epididymis / metabolism. Galectin 3 / metabolism. Sexual Maturation / physiology. Testis / metabolism

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  • (PMID = 19043307.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Galectin 3
  • [Other-IDs] NLM/ PMC2811773
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57. Zhao YG, Zhou J, Zhang XJ, Men XW, Wang R, Zhou F, Chen DH, Yu ZY, Shi HB: [Effects of experimental varicocele on the apoptosis of epididymis epithelium and synthesizing function of the epididymis in rats]. Zhonghua Nan Ke Xue; 2006 Jul;12(7):619-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effects of experimental varicocele on the apoptosis of epididymis epithelium and synthesizing function of the epididymis in rats].
  • OBJECTIVE: To study the relationships of experimental varicocele to the apoptosis of epididymis epithelium and changes of the contents of alpha-1,4-glucosidase and sialic acid from the unilateral epididymis in adolescent rats, and to investigate the effects of varicocele on the unilateral epididymis epithelium.
  • The epididymides were collected for detecting the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid by using spectrophotometry.
  • RESULTS: Seven days after the establishment of the left varicocele model, the index of the apoptosis of the left epididymis epithelium was significantly higher (P < 0.001) and the contents of alpha-1,4-glucosidase and sialic acid significantly lower (P < 0.05, P < 0.005) in the experimental group than in the control.
  • CONCLUSION: The results suggest that unilateral varicocele may increase the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid and subsequently affect the synthesizing and secretory function of the epididymis.
  • [MeSH-major] Apoptosis. Epididymis / pathology. Varicocele / metabolism. Varicocele / pathology

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  • (PMID = 16894940.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.2.1.20 / alpha-Glucosidases; GZP2782OP0 / N-Acetylneuraminic Acid
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58. Pruneda A, Pinart E, Bonet S, Yeung CH, Cooper TG: Study of the polyol pathway in the porcine epididymis. Mol Reprod Dev; 2006 Jul;73(7):859-65
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  • [Title] Study of the polyol pathway in the porcine epididymis.
  • Concentrations of D-glucose, D-fructose and D-sorbitol were quantified in porcine epididymal fluid by spectrofluorimetric assays and aldose reductase (AR) and sorbitol dehydrogenase (SDH) were located immunohistochemically in the epididymal epithelium.
  • SDH was present apically and basally in epithelial cells throughout the epididymis and in the lumen.
  • [MeSH-major] Epididymis / enzymology. Fructose / metabolism. Glucose / metabolism. Sorbitol / metabolism. Sus scrofa / metabolism

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  • (PMID = 16596633.001).
  • [ISSN] 1040-452X
  • [Journal-full-title] Molecular reproduction and development
  • [ISO-abbreviation] Mol. Reprod. Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 30237-26-4 / Fructose; 506T60A25R / Sorbitol; EC 1.1.1.14 / L-Iditol 2-Dehydrogenase; EC 1.1.1.21 / Aldehyde Reductase; IY9XDZ35W2 / Glucose
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59. Pal PC, Manocha M, Kapur MM, Rao DN, Sharma RS, Rajalakshmi M: Obstructive infertility: changes in the histology of different regions of the epididymis and morphology of spermatozoa. Andrologia; 2006 Aug;38(4):128-36
MedlinePlus Health Information. consumer health - Male Infertility.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obstructive infertility: changes in the histology of different regions of the epididymis and morphology of spermatozoa.
  • In the present study, the effects of prolonged obstruction in different regions of the human epididymis on its histology and on the spermatozoa retained at the site of obstruction were assessed.
  • Men who were confirmed of having obstruction of the epididymis underwent vasoepididymostomy (VEA) for surgical correction of the obstruction.
  • At the time of surgery, fluid from the epididymal tubule above the site of obstruction was aspirated and examined for sperm profile.
  • Epididymal tissue, collected at the site of obstruction, was processed for assessment of histological changes and also used to identify the site of obstruction.
  • Prolonged obstruction of the epididymis has caused degeneration of the epididymal epithelium, gradual decrease in the diameter of the tubule and tubular lumen and increase in the intertubular connective tissue.
  • Sperm aspirated from the caput epididymal fluid showed sluggish pattern of motility only in one out of the six subjects, whereas spermatozoa collected from the cauda epididymal fluid showed rapid linear progressive motility in one of three subjects.
  • These results are discussed in relation to the role of the epididymis in investing spermatozoa with motility and fertilizing capacity.
  • [MeSH-major] Epididymis / pathology. Epididymis / surgery. Genital Diseases, Male / pathology. Genital Diseases, Male / surgery. Infertility, Male / pathology. Spermatozoa / pathology

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  • (PMID = 16872464.001).
  • [ISSN] 0303-4569
  • [Journal-full-title] Andrologia
  • [ISO-abbreviation] Andrologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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60. Deshpande SN, Vijayakumar G, Rao AJ: Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis. Reprod Biomed Online; 2009 Apr;18(4):555-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis.
  • A role for oestrogen in regulating fluid reabsorption in the monkey epididymis was recently demonstrated.
  • Here, these studies are extended to identify potential oestrogen-regulated proteins in the cauda region of monkey epididymis treated with vehicle and oestrogen receptor antagonist (ICI 182780).
  • The results of the present study establish the presence of WNT4 in the monkey epididymis and its regulation by oestrogen, and suggest a role for WNT4 in maintaining epididymal homeostasis.
  • [MeSH-major] Epididymis / metabolism. Estrogens / metabolism. Macaca radiata / metabolism. Water-Electrolyte Balance / physiology. Wnt Proteins / metabolism

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  • (PMID = 19400999.001).
  • [ISSN] 1472-6491
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Estrogens; 0 / Receptors, Estrogen; 0 / WNT4 protein, human; 0 / Wnt Proteins; 0 / Wnt4 Protein; 0 / Wnt4 protein, mouse; 22X328QOC4 / fulvestrant; 4TI98Z838E / Estradiol
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61. Silva EJ, Queiróz DB, Honda L, Avellar MC: Glucocorticoid receptor in the rat epididymis: expression, cellular distribution and regulation by steroid hormones. Mol Cell Endocrinol; 2010 Aug 30;325(1-2):64-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glucocorticoid receptor in the rat epididymis: expression, cellular distribution and regulation by steroid hormones.
  • Curiously, little is known about glucocorticoid-induced effects on the epididymis, an androgen-dependent tissue with vital role on sperm maturation.
  • Here, RT-PCR, Western blot and immunohistochemical studies were performed to evaluate expression, cellular distribution and hormonal regulation of glucocorticoid receptor (GR) along rat epididymis.
  • The rat orthologue of human GRalpha (mRNA and protein) was detected in caput, corpus and cauda epididymis and immunolocalized in the nucleus and cytoplasm of different epididymal cells (epithelial, smooth muscle and interstitial cells) and nerve fibers.
  • Changes in plasma glucocorticoid and androgen levels differentially regulated GR expression in caput and cauda epididymis by homologous and heterologous mechanisms.
  • In vivo treatment with dexamethasone significantly changed the expression of glucocorticoid-responsive genes and induced ligand-dependent GR nuclear translocation in epithelial cells from epididymis, indicating that GR is fully active in this tissue.
  • Heterologous regulation of androgen receptor expression by glucocorticoids was also demonstrated in cauda epididymis.
  • Our results demonstrate that the epididymis is under glucocorticoid regulation, opening new insights into the roles of this hormone in male fertility.
  • [MeSH-major] Epididymis / drug effects. Epididymis / metabolism. Gonadal Steroid Hormones / pharmacology. Receptors, Glucocorticoid / genetics. Receptors, Glucocorticoid / metabolism

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20573576.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / D43TW/HD00627
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Androgens; 0 / Glucocorticoids; 0 / Gonadal Steroid Hormones; 0 / Receptors, Glucocorticoid
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62. Xue X, Qiu SM, Qiu SD, Zhang QY, Tian H: [Effects of experimental varicocele on CRES protein in the testis and epididymis of adolescent rats]. Zhonghua Nan Ke Xue; 2006 Nov;12(11):974-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effects of experimental varicocele on CRES protein in the testis and epididymis of adolescent rats].
  • OBJECTIVE: To investigate the effects of experimental left varicocele (ELV) on the cystatin-related epididymal spermatogenic (CRES) protein in the testis and epididymis of adolescent rats.
  • METHODS: The ELV model of Sprague-Dawley (SD) male adolescent rats was established, and the expression of CRES protein in the testis and epididymis was detected by immunohistochemistry and Western-blot at 2 and 4 weeks after surgery.
  • RESULTS: Immunohistochemistry and Western-blot detected CRES protein in both the testis and the epididymis of the ELV rats and the control rats.
  • Within the epididymis, CRES protein was expressed mainly in the cytoplasm of the principal cells of epididymal epithelia.
  • CONCLUSION: CRES protein expressed in both the testis and epididymis of adolescent rats and the expression is stage-specific and cell-specific in the testis and segment-specific and cell-specific in the epididymis.
  • [MeSH-major] Cystatins / biosynthesis. Epididymis / metabolism. Testis / metabolism. Varicocele / metabolism

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  • (PMID = 17146919.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cst8 protein, rat; 0 / Cystatins
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63. Parlevliet JM, Pearl CA, Hess MF, Famula TR, Roser JF: Immunolocalization of estrogen and androgen receptors and steroid concentrations in the stallion epididymis. Theriogenology; 2006 Sep 1;66(4):755-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolocalization of estrogen and androgen receptors and steroid concentrations in the stallion epididymis.
  • The presence of steroids and their receptors throughout development, specifically androgen receptor (AR), estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), in the epididymis of a high estrogen producing species like the stallion has not been determined.
  • Epididymal and testicular samples were collected for analysis of testosterone and estradiol-17beta (E(2)) concentrations and for immunolocalization of AR, ERalpha and ERbeta.
  • The concentration of testosterone in the testis and epididymis were not different among age groups (P>0.05).
  • This lack of change in testosterone concentration and receptor localization suggests that testosterone is important for both development and maintenance of epididymal function.
  • There was an age-related increase in E(2) concentrations in all regions of the epididymis (P<0.05), suggesting that E(2) is also important for adult function.
  • In peri-pubertal animals, ERalpha immunostaining was most prominent and estradiol was similarly present in all three epididymal regions; this suggests that estradiol also plays a key role in the maturation of the stallion epididymis during the pubertal transition when sperm first arrive in the epididymis.
  • In conclusion, these results suggest that the stallion epididymis is regulated by both androgens and estrogens throughout development and that estradiol is more important to epididymal function in the stallion than previously believed.
  • [MeSH-minor] Animals. Epididymis / metabolism. Immunohistochemistry. Male. Testis / metabolism

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  • (PMID = 16530259.001).
  • [ISSN] 0093-691X
  • [Journal-full-title] Theriogenology
  • [ISO-abbreviation] Theriogenology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0 / Receptors, Androgen; 0 / Receptors, Estrogen
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64. de Andrade SF, Oliva SU, Klinefelter GR, De Grava Kempinas W: Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. Toxicol Pathol; 2006;34(6):730-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty.
  • Herein, we utilized hemicastration and electron microscopy to confirm that the epididymis is a definitive target of gossypol.
  • Although exposure to gossypol from weaning through puberty caused a significant decrease in daily sperm production, as well as in the concentration of sperm in the epididymis, serum testosterone levels and reproductive organ weights were not altered.
  • In gossypol treated rats, sperm morphology was compromised severely, but the epithelium in testis and epididymis appeared morphologically normal.
  • (1) principal cells exfoliated from the epididymal epithelium;.
  • (2) epididymal epithelial cell cytoplasm containing degenerating sperm; and (3) degenerating epithelial cells, consisting of vesicles and particles of different sizes, forms and densities.
  • Taken together, the data confirm that gossypol targets the epididymis, disturbing both the structure and function of this organ, and presumably disrupts sperm maturation.
  • [MeSH-major] Aging. Epididymis / drug effects. Epididymis / ultrastructure. Gossypol / toxicity. Spermatogenesis / drug effects

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  • (PMID = 17162530.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 30237-26-4 / Fructose; 3XMK78S47O / Testosterone; KAV15B369O / Gossypol
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65. Johnston DS, Jelinsky SA, Bang HJ, DiCandeloro P, Wilson E, Kopf GS, Turner TT: The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis. Biol Reprod; 2005 Sep;73(3):404-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis.
  • Maturation of spermatozoa, including the acquisition of motility and the ability to undergo capacitation, occurs during transit through the dynamic environment of the epididymis.
  • The microenvironments created along the length of the epididymal tubule are essential to the molecular modifications of spermatozoa that result in fertile gametes.
  • In the current study, 10 morphologically distinct segments of the mouse epididymis were identified by microdissection.
  • We hypothesized that the changing environments of the epididymal lumen are established by differential gene expression among these segments.
  • More than 17,000 genes are expressed in the mouse epididymis, compared with about 12,000 genes identified from whole epididymal samples.
  • Screening a panel of normal mouse tissues identified both epididymal-selective and epididymal-specific transcripts.
  • These analyses elucidate the changes in gene expression along the length of the epididymis for 17,000 expressed transcripts and provide a powerful resource for the research community in future studies of the biological factors that mediate epididymal sperm maturation.
  • [MeSH-major] Epididymis / metabolism. Gene Expression Profiling

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  • (PMID = 15878890.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK45179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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66. Gravas S, Georgiadis T, Vassiliadis F, Kehayas P: Juvenile granulosa cell tumor of the epididymis. Urol Int; 2007;78(3):278-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile granulosa cell tumor of the epididymis.
  • We report the first case of a juvenile granulosa cell tumor of the epididymis in a young man.
  • [MeSH-major] Epididymis. Genital Neoplasms, Male / pathology. Granulosa Cell Tumor / pathology

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17406141.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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67. Nair N, Bedwal S, Prasad S, Saini MR, Bedwal RS: Short-term zinc deficiency in diet induces increased oxidative stress in testes and epididymis of rats. Indian J Exp Biol; 2005 Sep;43(9):786-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Short-term zinc deficiency in diet induces increased oxidative stress in testes and epididymis of rats.
  • In order to determine the effects of Zinc deficient diet on oxidative stress in testis and epididymis, various parameters viz: total proteins, lipid peroxidation, hydroperoxides, antioxidant capacity and enzymatic activities are evaluated in rats fed on zinc deficient diet for 2, 4 and 6 weeks.
  • Total proteins, water and lipid solouble antioxidant capacity decreased while lipid peroxidation (TBARS) and hydroperoxides concentration increased in testes, caput and cauda epididymis except in 2ZD (testes) where hydroperoxides revealed a significant decrease.
  • GSH decreased in testes and caput and cauda epididymis.
  • GPx and gamma-GT activities increased in testes and caput and cauda epididymis of zinc deficient rats.
  • Further, GST increased in testes but exhibited decreases after 2 and 4 weeks and an increase after 6 weeks in caput and cauda epididymis of zinc deficient rats.
  • GR activities decreased in testes but it increased in caput and cauda epididymis of zinc deficient rats.
  • [MeSH-major] Epididymis / drug effects. Oxidative Stress. Testis / drug effects. Zinc / deficiency

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  • (PMID = 16187529.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Fatty Acids; 0 / Reactive Oxygen Species; 0 / Thiobarbituric Acid Reactive Substances; EC 2.3.2.2 / gamma-Glutamyltransferase; EC 2.5.1.18 / Glutathione Transferase; GAN16C9B8O / Glutathione; J41CSQ7QDS / Zinc
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68. D'cruz SC, Mathur PP: Effect of piperine on the epididymis of adult male rats. Asian J Androl; 2005 Dec;7(4):363-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of piperine on the epididymis of adult male rats.
  • AIM: To study the effect of piperine on the epididymal antioxidant system of adult male rats.
  • Twenty-four hours after the last treatment, the rats were weighed and killed with ether and the epididymis was dissected from the bodies.
  • Sperm collected from the cauda region of the epididymis was used for the assessment of its count, motility and viability.
  • Caput, corpus and cauda regions of the epididymis were separated and homogenized separately to obtain 10 % homogenates.
  • The weights of the caput, corpus and cauda regions of the epididymis significantly decreased at dose of 100 mg/kg.
  • Epididymal sperm count and motility decreased at 10 mg/kg and 100 mg/kg, and sperm viability decreased significantly at 100 mg/kg.
  • Sialic acid levels in the epididymis decreased significantly at 100 mg/kg while significant decrease in the cauda region alone was observed at 10 mg/kg.
  • CONCLUSION: Piperine caused a decrease in the activity of antioxidant enzymes and sialic acid levels in the epididymis and thereby increased reactive oxygen species levels that could damage the epididymal environment and sperm function.
  • [MeSH-major] Alkaloids / pharmacology. Antioxidants / metabolism. Epididymis / drug effects. Epididymis / metabolism. Piper. Piperidines / pharmacology

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  • (PMID = 16281082.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Antioxidants; 0 / Benzodioxoles; 0 / Piperidines; 0 / Polyunsaturated Alkamides; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; EC 1.8.1.7 / Glutathione Reductase; GZP2782OP0 / N-Acetylneuraminic Acid; U71XL721QK / piperine
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69. Zhou X, Wang J, Liu Q, Shen J, Zheng M, Zhang Y: Identification of the gene imds-60 in mouse epididymis. Acta Biochim Biophys Sin (Shanghai); 2007 Dec;39(12):939-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of the gene imds-60 in mouse epididymis.
  • Sperm maturation, including the acquisition of motility and the full ability to fertilize oocyte, occurs during its transit through the dynamic environment of the epididymis.
  • Based on an expressed sequence tag named imds-60, which was first found in uterus but is highly expressed in epididymis, the full-length cDNA sequence of imds-60 with a complete open reading frame was obtained in mouse epididymis by GenBank searching, polymerase chain reaction-based procedures, and 5'- and 3'-rapid amplification of cDNA ends.
  • Northern blot analysis showed that the mRNA of imds-60 was highly expressed in epididymis but at a rather lower level in uterus, seminal vesicle gland, and stomach.
  • Further study revealed that the mRNA of imds-60 is only expressed in corpus and cauda regions of epididymis, not in caput.
  • [MeSH-major] Cell Communication / physiology. Deoxyribonucleases / genetics. Deoxyribonucleases / metabolism. Epididymis / metabolism. Membrane Proteins / genetics. Membrane Proteins / metabolism. Spermatogenesis / physiology

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  • (PMID = 18064386.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Imds-60 protein, mouse; 0 / Membrane Proteins; EC 3.1.- / Deoxyribonucleases
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70. Da Silva N, Shum WW, Breton S: Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis. Asian J Androl; 2007 Jul;9(4):476-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis.
  • Luminal acidification in the epididymis is an important process for the regulation of male fertility.
  • Although significant bicarbonate reabsorption is achieved by principal cells in the proximal regions of the epididymis, clear and narrow cells are specialized for net proton secretion.

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  • (PMID = 17589784.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK38452; United States / NIDDK NIH HHS / DK / DK43351; United States / NICHD NIH HHS / HD / R01 HD040793; United States / NIDDK NIH HHS / DK / P01 DK038452; United States / NIDDK NIH HHS / DK / DK57521; United States / NICHD NIH HHS / HD / HD40793
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bicarbonates; 0 / Proton Pumps; EC 3.6.1.- / Adenosine Triphosphatases; EC 4.6.1.1 / Adenylyl Cyclases
  • [Number-of-references] 52
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71. Wang HF, Shi BK, Chu MM, Zhang KQ, Zhu YF, Li YZ, Wang HX: [Expression of hypoxia induced factor-1alpha and function of epididymis in varicocele: experiment with rats]. Zhonghua Yi Xue Za Zhi; 2008 Jun 24;88(24):1670-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of hypoxia induced factor-1alpha and function of epididymis in varicocele: experiment with rats].
  • OBJECTIVE: To investigate the expression of hypoxia induced factor-la (HIF-1alpha) and the content of sialic acid and carnitine in the epididymis in varicocele (VC) and to investigate the mechanism of induction of epididymis dysfunction by VC.
  • 49 days after the operation the left epididymis samples were collected.
  • The contents of sialic acid and carnitine in the epididymis of the experimental group were 6.3 +/- 2.3 and 1.1 +/- 0.3 respectively, both significantly lower than those of the control group (24.7 +/- 4.4 and 2.8 +/- 0.6) and sham operation group (26.1 +/- 4.4 and 3.2 +/- 0.6) (all P < 0.05).
  • The contents of sialic acid and carnitine in the epididymis were significantly negatively correlated with the HIF-1alpha expression (r = -0.649, P = 0.017; r = -0.666, P = 0.013).
  • CONCLUSION: VC causes epididymal hypoxia and epididymal dysfunction, and hypoxia plays an important role in VC induced epididymal dysfunction.
  • [MeSH-major] Epididymis / physiopathology. Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis. Varicocele / physiopathology

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  • (PMID = 19024534.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1, alpha Subunit; GZP2782OP0 / N-Acetylneuraminic Acid; S7UI8SM58A / Carnitine
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72. Pearl CA, Roser JF: Expression of lactoferrin in the boar epididymis: effects of reduced estrogen. Domest Anim Endocrinol; 2008 Feb;34(2):153-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of lactoferrin in the boar epididymis: effects of reduced estrogen.
  • The estrogen regulation of lactoferrin in the epididymis of the boar, a high estrogen-producing male, is unknown.
  • This study was designed to test the hypothesis that lactoferrin expression in the boar epididymis is regulated by estrogen.
  • Epididymal tissue was collected at castration and fixed for immunolocalization of lactoferrin.
  • Epididymal and testicular tissues were also collected from five mature boars (1-2.5 years) and fixed for immunocytochemistry (ICC).
  • Reduced endogenous estrogen in the epididymis during development did not affect the intensity of immunostaining between control and Letrozole-treated animals.
  • Lactoferrin expression in the epididymis of the developing boar does not appear to be regulated by estrogen.
  • [MeSH-major] Epididymis / metabolism. Estradiol / metabolism. Lactoferrin / biosynthesis. Swine / metabolism

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  • (PMID = 17320339.001).
  • [ISSN] 0739-7240
  • [Journal-full-title] Domestic animal endocrinology
  • [ISO-abbreviation] Domest. Anim. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 4TI98Z838E / Estradiol; 7LKK855W8I / letrozole; EC 3.4.21.- / Lactoferrin
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73. Tamadon A, Nikahval B, Sepehrimanesh M, Mansourian M, Naeini AT, Nazifi S: Epididymis ligation: a minimally invasive technique for preparation of teaser rams. Vet Surg; 2010 Jan;39(1):121-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epididymis ligation: a minimally invasive technique for preparation of teaser rams.
  • OBJECTIVE: To describe a minimally invasive technique for preparation of teaser rams by needle-assisted ligation through the tail of the epididymis.
  • METHODS; After local anesthesia, epididymis ligation was achieved by restraining the testis distally within the scrotal sac and passing suture through a hypodermic needle inserted between tail of epididymis and distal pole of testis, caudomedial to craniolateral through the scrotum.
  • This resulted in the suture forming a complete loop around the epididymis.
  • The suture ends were tied ligating the epididymis.
  • RESULTS: Epididymis ligation was accomplished without postoperative complications.
  • Three weeks after the epididymis ligation, no motile and live spermatozoa were found in ejaculates.
  • From 5 to 28 days after epididymis ligation, attraction to ewes and libido was unchanged and similar to 14 days before ligation.
  • [MeSH-major] Epididymis / surgery. Sheep / surgery. Sterilization, Reproductive / veterinary

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  • (PMID = 20210956.001).
  • [ISSN] 1532-950X
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Schön J, Neumann S, Wildt DE, Pukazhenthi BS, Jewgenow K: Localization of oestrogen receptors in the epididymis during sexual maturation of the domestic cat. Reprod Domest Anim; 2009 Jul;44 Suppl 2:294-301
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  • [Title] Localization of oestrogen receptors in the epididymis during sexual maturation of the domestic cat.
  • To study the role of oestrogens on epididymal function in the domestic cat, we analyzed the localization patterns of oestrogen receptors (ERs) within the epididymis of juvenile, pubertal and adults using immunohistochemistry.
  • Cat epididymal tissues obtained during routine castrations were fixed in chilled Bouin's solution and processed for immunohistochemistry with ER-specific antibodies.
  • In the juvenile epididymis, ERalpha was localized in the nuclei of epithelial cells of efferent ducts and undifferentiated epithelium of the ductus epididymis.
  • During puberty, ERalpha localization in the undifferentiated epithelium of the epididymis shifted from the nuclei to the cytoplasm and plasma membrane.
  • Oestrogen receptor-alpha level was highest in the pubertal and adult epididymis, especially within the cytoplasm and in plasma membranes of caput epithelial cells.
  • This finding was suggestive of a role in fluid reabsorption within the efferent ducts and the epididymis.
  • Interestingly, localization of ERbeta was neither influenced by age nor location within the epididymis and was ubiquitous throughout.
  • Results demonstrate that oestrogen actions within the epididymis may be predominantly mediated through ERalpha during sexual maturation in the domestic cat.
  • [MeSH-major] Epididymis / physiology. Gene Expression Regulation, Developmental / physiology. Receptors, Estrogen / metabolism. Sexual Maturation / physiology

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  • (PMID = 19754590.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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75. Lachance C, Fortier M, Thimon V, Sullivan R, Bailey JL, Leclerc P: Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa. Int J Androl; 2010 Feb;33(1):33-44
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  • [Title] Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa.
  • The cellular distribution of Hsp60 and Grp78 proteins was analysed in the human testis and epididymis by immunohistochemical approaches.
  • DNA microarray technology was used to analyse HSP60 and GRP78 gene expression along human epididymis.
  • Grp78 protein was also observed in the epididymal epithelium, whereas no Hsp60 staining was observed in this organ by immunohistochemistry.
  • The presence of both Hsp60 and Grp78 RNA in human epididymis was confirmed by microarrays.
  • [MeSH-major] Epididymis / metabolism. Heat-Shock Proteins / metabolism. Molecular Chaperones / metabolism. Spermatozoa / metabolism. Testis / metabolism

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  • (PMID = 19207617.001).
  • [ISSN] 1365-2605
  • [Journal-full-title] International journal of andrology
  • [ISO-abbreviation] Int. J. Androl.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Heat-Shock Proteins; 0 / Molecular Chaperones; 0 / molecular chaperone GRP78
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76. Johnston DS, Turner TT, Finger JN, Owtscharuk TL, Kopf GS, Jelinsky SA: Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling. Asian J Androl; 2007 Jul;9(4):522-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling.
  • As part of our efforts to identify novel contraceptive targets in the epididymis we performed transcriptional profiling on each of the 10 and 19 segments of the mouse and rat epididymidis, respectively, using Affymetrix whole genome microarrays.
  • A total of 17 096 and 16 360 probe sets representing transcripts were identified as being expressed in the segmented mouse and rat epididymal transcriptomes, respectively.
  • Comparison of the expressed murine transcripts against a mouse transcriptional profiling database derived from 22 other mouse tissues identified 77 transcripts that were expressed uniquely in the epididymis.
  • RT-PCR analysis confirmed epididymis-specific expression of Defensin Beta 13 and identified two additional genes with expression restricted only to the epididymis and testis.
  • Comparison of the 16 360 expressed transcripts in the rat epididymis with data of 21 other tissues from a rat transcriptional profiling database identified 110 transcripts specific for the epididymis.
  • Only Defensin 22 (E3 epididymal protein) was shown to be completely specific for the epididymis.
  • In addition, 14 transcripts showed more than 100-fold selective expression in the epididymis.
  • The products of these genes might play important roles in epididymal and/or sperm function and further investigation and validation as contraceptive targets are warranted.
  • [MeSH-major] Epididymis / physiology. Gene Expression Profiling / methods. Transcription, Genetic

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  • (PMID = 17589790.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 63231-63-0 / RNA
  • [Number-of-references] 13
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77. Ahmed M, Nazeer Ahamed R, Aladakatti RH: Effect of benzene extract of Ocimum sanctum leaves on cauda epididymis of albino rats. J Basic Clin Physiol Pharmacol; 2009;20(1):29-41
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  • [Title] Effect of benzene extract of Ocimum sanctum leaves on cauda epididymis of albino rats.
  • In the present study, an attempt has been made to assess the effect of benzene extract of Ocimum sanctum leaves on ultrastructural changes in epithelial cells of the cauda epididymis and fertility of male albino rats.
  • The results indicate, in cauda epididymis, a significant reduction in epithelial height and nuclei diameter of epithelial cells.
  • An ultra study revealed that, in general, the cauda epididymis was affected and in particular, the principal, clear and basal cells were highly disturbed.
  • [MeSH-major] Epididymis / drug effects. Ocimum. Plant Extracts / pharmacology

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  • (PMID = 19601393.001).
  • [ISSN] 0792-6855
  • [Journal-full-title] Journal of basic and clinical physiology and pharmacology
  • [ISO-abbreviation] J Basic Clin Physiol Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Extracts; J64922108F / Benzene
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78. Da Silva N, Silberstein C, Beaulieu V, Piétrement C, Van Hoek AN, Brown D, Breton S: Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Biol Reprod; 2006 Feb;74(2):427-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postnatal expression of aquaporins in epithelial cells of the rat epididymis.
  • AQP9 is abundantly expressed in the efferent ducts, the epididymis, and the vas deferens, where it could represent an important apical pathway for transmembrane water and solute movement.
  • To undertake a systematic analysis of the expression of known AQPs in the postnatal and adult rat epididymis, we examined the expression of their respective mRNAs in epithelial cells isolated by laser capture microdissection (LCM), and we determined their corresponding protein expression pattern by immunofluorescence and Western blotting.
  • Our data show that, whereas AQP9 is the main AQP of the epididymis, the mRNA specific for Aqp2, 5, 7, and 11 are also expressed in epididymal epithelial cells.
  • No AQP2 protein was detected in the adult epididymis, indicating that posttranscriptional mechanisms are involved in the regulation of AQP2 expression.
  • In addition, epididymal epithelial cells express significant amounts of the mRNAs coding for AQP7 and 11.
  • No mRNA or protein for AQPs 0, 4, 6, and 8 were detectable in epithelial cells, and Aqp1 was detected in whole epididymal samples, but not in epithelial cells.
  • Thanks to the recent development of microdissection technologies, our observations suggest that epididymal epithelial cells express several members of the AQP family with a region-specific pattern.
  • AQPs may be involved not only in the transepithelial transport of water in the epididymis but also in the postnatal development of this organ, as suggested by the differential expression of AQP2.
  • [MeSH-major] Aquaporins / metabolism. Epididymis / growth & development. Epididymis / metabolism. Gene Expression Regulation, Developmental

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  • (PMID = 16221990.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK38452; United States / NIDDK NIH HHS / DK / DK43351; United States / NIDDK NIH HHS / DK / DK57521
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aqp2 protein, rat; 0 / Aquaporin 2; 0 / Aquaporins; 0 / RNA, Messenger
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79. Wilhelm B, Brandenburger T, Post H, Aumüller G: Expression and localization of PMCA4 in rat testis and epididymis. Histochem Cell Biol; 2008 Mar;129(3):331-43
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  • [Title] Expression and localization of PMCA4 in rat testis and epididymis.
  • We analyzed whether sperm PMCA4 is formed in the rat during spermatogenesis or is synthesized in the epididymis and transferred onto sperm during sperm maturation.
  • We could show that PMCA4 is conserved in sperm from testis to epididymis.
  • In testis, PMCA4 mRNA was restricted to spermatogonia and early spermatocytes, while the PMCA4 protein was detected in spermatogonia, late spermatocytes, spermatids and in epididymal sperm.
  • In epididymis PMCA4 mRNA was localized in basolateral plasma membranes of epithelial cells of the caput, corpus and cauda epididymidis.
  • In the epididymal corpus and cauda, PMCA4 mRNA and protein, respectively, was localized and in peritubular cells.
  • Furthermore, we detected an identical distribution of PMCA4a and b splice variants in rat testis, epididymal corpus and cauda.
  • [MeSH-major] Epididymis / metabolism. Plasma Membrane Calcium-Transporting ATPases / genetics. Plasma Membrane Calcium-Transporting ATPases / metabolism. Spermatozoa / metabolism. Testis / metabolism

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  • (PMID = 18057950.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.6.3.8 / Plasma Membrane Calcium-Transporting ATPases
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80. Ai QY, Tian H, Zhang J, Ma L, Miao NZ, Huo YW, Wang LR, Qiu SD, Zhang QY: [Expressions of VEGF and Flt-1 in the testis, epididymis and epididymal sperm of adolescent rats]. Zhonghua Nan Ke Xue; 2008 Oct;14(10):871-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expressions of VEGF and Flt-1 in the testis, epididymis and epididymal sperm of adolescent rats].
  • OBJECTIVE: To study the expressions of the vascular endothelial growth factor (VEGF) and its receptor fms-like tyrosine kinase-1 (Flt-1) in the testis, epididymis and epididymal sperm of adolescent rats and explore the functions of both the proteins in the male reproductive system.
  • METHODS: The expressions of VEGF and Flt-1 were detected in 20 adolescent SD rats, immunohistochemical staining used for both the testis and the epididymis and immunofluorescent staining for sperm.
  • RESULTS: VEGF and Flt-1 proteins were specifically present in the testis, epididymis and sperm.
  • In the epididymis, the cell-specific and region-specific expressions of VEGF and Flt-1 proteins were observed in the principal cells of epididymal epithelia, VEGF in the whole epididymis, while Flt-1 only in the caput and cauda segments.
  • CONCLUSION: The specific expression patterns of VEGF and Flt-1 in the rat testis, epididymis and sperm indicate that they may independently or collectively affect spermatogenesis and spermiotelcosis in either an autocrinological or a
  • [MeSH-major] Epididymis / metabolism. Spermatozoa / metabolism. Testis / metabolism. Vascular Endothelial Growth Factor A / biosynthesis. Vascular Endothelial Growth Factor Receptor-1 / biosynthesis

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  • (PMID = 19157092.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1
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81. Kantarci F, Ozer H, Adaletli I, Mihmanli I: Cystic appendix epididymis: a sonomorphologic study. Surg Radiol Anat; 2005 Dec;27(6):557-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic appendix epididymis: a sonomorphologic study.
  • We aimed to describe the morphologic characteristics of the appendix epididymis that appears cystic on ultrasound (US) examinations.
  • Cystic appendix epididymis on US examinations was classified according to the presence of the stalk and size of the cyst.
  • Of them, 241 were appendix testis (44.3%) and 96 (17.6%) were appendix epididymis.
  • The most common morphology in our study was the stalked appendix epididymis with nonseptated unilocular cysts (31.4%).
  • In conclusion, cystic appearance of the appendix epididymis on sonographic examinations is frequent and it should not be mistaken with a torsed testicular appendage.
  • [MeSH-major] Epididymis / diagnostic imaging

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  • (PMID = 16195812.001).
  • [ISSN] 0930-1038
  • [Journal-full-title] Surgical and radiologic anatomy : SRA
  • [ISO-abbreviation] Surg Radiol Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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82. Shayu D, Chennakesava CS, Rao AJ: Differential expression and antibacterial activity of WFDC10A in the monkey epididymis. Mol Cell Endocrinol; 2006 Oct 19;259(1-2):50-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression and antibacterial activity of WFDC10A in the monkey epididymis.
  • The ability of the epididymis to perform its diverse functions stems from its regionalized gene and protein expression patterns.
  • The differences in the gene expression patterns of the caput and cauda regions of the bonnet monkey epididymis were compared using the technique of differential display reverse transcriptase polymerase chain reaction.
  • Expression of genes such as mWFDC10A may be essential in providing the first line of defense against microbial infections to the epididymal tract and thus rendering protection to the male gametes sheltered within the epididymis.
  • [MeSH-major] Anti-Bacterial Agents / metabolism. Anti-Bacterial Agents / pharmacology. Epididymis / metabolism. Haplorhini / metabolism. Proteins / metabolism. Proteins / pharmacology

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  • (PMID = 16996203.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Peptides; 0 / Proteins
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83. Itoh M, Terayama H, Naito M, Ogawa Y, Tainosho S: Tissue microcircumstances for leukocytic infiltration into the testis and epididymis in mice. J Reprod Immunol; 2005 Oct;67(1-2):57-67
MedlinePlus Health Information. consumer health - Autoimmune Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue microcircumstances for leukocytic infiltration into the testis and epididymis in mice.
  • However, the testis and epididymis are known as immunologically privileged organs.
  • In particular, the blood-testis barrier (BTB) formed by Sertoli cells and the blood-epididymal barrier formed by epididymal epithelial cells protect autoimmunogeneic spermatozoa from attack by the self immune system.
  • The immune privileged circumstances in the testis and epididymis have been demonstrated by many studies to involve a local transplantation system.
  • The testicular interstitium in mice is resistant to vasculitis, lymphangitis, spermatic granuloma and polymorphonuclear cell infiltration: however, the epididymal interstitium is vulnerable to them.
  • Unexpectedly, injections of viable epididymal spermatozoa (ES) did not evoke any autoimmune inflammation in the epididymides.
  • Therefore, the testis rather than the epididymis may easily become an unprivileged organ as to autoimmunity under some special conditions.
  • [MeSH-major] Autoimmune Diseases / immunology. Epididymis / immunology. Leukocytes / immunology. Orchitis / immunology. Spermatozoa / immunology. Testis / immunology

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  • (PMID = 16111766.001).
  • [ISSN] 0165-0378
  • [Journal-full-title] Journal of reproductive immunology
  • [ISO-abbreviation] J. Reprod. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Number-of-references] 66
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84. Bahathiq AO, Stewart RL, Baxter L, Wells M, Moore HD, Ledger WL: Tissue immunoexpression and messenger ribonucleic acid localization of inhibin/activin subunit in human epididymis. Fertil Steril; 2005 Jan;83(1):78-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue immunoexpression and messenger ribonucleic acid localization of inhibin/activin subunit in human epididymis.
  • OBJECTIVE: To determine the expression of inhibin betaA and betaB subunits and follistatin and the ability of human epididymal epithelium to synthesize these molecules.
  • DESIGN: The main aim of this study was to investigate the expression of inhibin alpha, betaA, and betaB-subunits and follistatin in human epididymis with immunohistochemistry, in situ hybridization, and Western blotting in adult life.
  • PATIENT(S): Epididymes were obtained from 10 men undergoing routine vasectomy or surgery for benign disease at the Royal Hallamshire Hospital, Sheffield, United Kingdom.
  • MAIN OUTCOME MEASURE(S): Immunoexpression of activin betaA and betaB subunits and follistatin proteins and mRNA in human caput and cauda epididymis.
  • RESULT(S): Positive immunoexpression for activin betaA and betaB subunits and follistatin were detected in different parts of the epididymis epithelium.
  • In situ hybridization indicated positive mRNA localization signal in both caput and cauda epididymal epithelium.
  • CONCLUSION(S): Activins betaA and betaB subunits, but not inhibin alpha subunit, were detected in epididymal epithelium.
  • [MeSH-major] Epididymis / chemistry. Follistatin / analysis. Inhibin-beta Subunits / analysis. Inhibins / analysis

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  • (PMID = 15652891.001).
  • [ISSN] 0015-0282
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Follistatin; 0 / RNA, Messenger; 0 / inhibin beta A subunit; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; 93443-12-0 / Inhibin-beta Subunits
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85. García-Tomás M, Sánchez J, Piles M: Post-natal sexual development of testis and epididymis in the rabbit: variability and relationships among macroscopic and microscopic markers. Anim Reprod Sci; 2009 Feb;110(3-4):347-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-natal sexual development of testis and epididymis in the rabbit: variability and relationships among macroscopic and microscopic markers.
  • The present work was performed to examine the existence of some relationships between macroscopic and microscopic traits of testis and epididymis in rabbit.
  • The variables studied were live weight (LW), testis length (TL), testis width (TWh), testis weight (TW), testis volume (TV), epididymis length (EL), epididymis width (EWh), epididymis weight (EW), epididymis volume (EV), percentage of seminiferous tubules with presence of lumen (STL), percentage of seminiferous tubules with presence of elongated spermatids (STES), percentage of seminiferous tubules with presence of spermatozoa (STS) and diameter of seminiferous tubules (STD).
  • Epididymis width and STS were located in the second PC.
  • Epididymis weight and EV were important in the definition of the first and third PC.
  • It has been not found correlation between traits related to either testis or epididymis size and variables related to active spermatogenesis.
  • [MeSH-major] Epididymis / growth & development. Rabbits / growth & development. Testis / growth & development

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  • (PMID = 18358648.001).
  • [ISSN] 1873-2232
  • [Journal-full-title] Animal reproduction science
  • [ISO-abbreviation] Anim. Reprod. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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86. Adebayo AO, Olurode SA: The morphology and morphometry of the epididymis in the greater cane rat (Thryonomys swinderianus Temmincks). Folia Morphol (Warsz); 2010 Nov;69(4):246-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The morphology and morphometry of the epididymis in the greater cane rat (Thryonomys swinderianus Temmincks).
  • The structure and morphometry of the epididymis in the greater cane rat were studied in this work.
  • From this work, the epididymis of the greater cane rat was observed to have a mean weight of 0.0365 ± 0.091 g, forming about 0.016% of the total body weight and an average volume of 0.36 ± 0.08 mL.
  • There was a positive correlation between the epididymal weights, testicular weight, and the body weight in this animal.
  • However, the gross divisions of the epididymis into head, body, and tail were not conspicuous in the cane rat; instead it had two divisions - the cranial and the caudal divisions.
  • In addition, based on the histological and histomorphometric analyses, five zones were observed in the epididymal epithelium of this animal.
  • This preliminary information on the epididymis will serve as a basis for further research on the epididymis of the greater cane rat and will contribute to the knowledge of the its reproductive biology, which will subsequently aid in the captive rearing and domestication of this animal.
  • [MeSH-major] Epididymis / anatomy & histology. Rodentia / anatomy & histology

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  • (PMID = 21120812.001).
  • [ISSN] 0015-5659
  • [Journal-full-title] Folia morphologica
  • [ISO-abbreviation] Folia Morphol. (Warsz)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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87. Khobarekar BG, Vernekar VJ, Prabagaran E, Raghavan VP, Bandivdekar AH: Studies on the expression of 80-kDa human sperm antigen in rat testis and epididymis. J Histochem Cytochem; 2007 Jul;55(7):753-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Studies on the expression of 80-kDa human sperm antigen in rat testis and epididymis.
  • The present study demonstrates the androgen-regulated expression of 80-kDa HSA in testis and epididymis of rat by immunohistochemistry (IHC), using its specific antibodies.
  • Developmental expression of 80-kDa HSA was investigated on days 10, 20, 40, 60, and 90 of age in the testis and epididymis by IHC, and relative staining intensity was estimated by image analysis using BIOVIS software.
  • On days 10 and 20, no significant staining was observed in the testis and epididymis, whereas it gradually increased from day 40 onwards.
  • The highest staining was seen on day 90 in both testis and epididymis.
  • It was observed that the staining intensity decreased following EDS treatment in rat testis as well as epididymis, and it was regained after supplementation with dihydrotestosterone.
  • Increased expression during sexual maturation at the time of testosterone surge and its regulation by antiandrogen/androgen treatment suggest androgen-dependent expression of 80-kDa HSA in rat testis and epididymis.
  • [MeSH-major] Antigens, Surface / biosynthesis. Epididymis / metabolism. Glycoproteins / biosynthesis. Testis / metabolism

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  • (PMID = 17371939.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Antigens, Surface; 0 / Glycoproteins; 0 / sperm antigen 80-kDa, human; 08J2K08A3Y / Dihydrotestosterone
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88. Balaji T, Aruna S, Ramanathan M, Srinivasan M, Menon VP: Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility. J Basic Clin Physiol Pharmacol; 2009;20(4):357-76
Hazardous Substances Data Bank. TESTOSTERONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility.
  • Significant levels of constitutive cyclooxygenase-2 (COX-2) are present in the male reproductive organs of rodents, especially in the vas deferens and epididymis.
  • In the epididymis, the sperm storehouse, COX-2 is thought to play a vital role in altering the membrane lipids of sperm.
  • The present study aims at localizing COX-2 in the epididymis and analyzing the effects of the preferential COX-2 inhibitor nimesulide.
  • COX-2 protein activity was nearly equal to that of COX-1 in the cauda epididymis.
  • Immunohistochemical studies showed an intense staining for COX-2 in the cauda epididymis but not in the caput epididymis.
  • [MeSH-major] Cyclooxygenase 2 Inhibitors / pharmacology. Epididymis / drug effects. Sperm Motility / drug effects. Sulfonamides / pharmacology

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  • (PMID = 20214021.001).
  • [ISSN] 0792-6855
  • [Journal-full-title] Journal of basic and clinical physiology and pharmacology
  • [ISO-abbreviation] J Basic Clin Physiol Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Fatty Acids; 0 / Prostaglandins; 0 / Sulfonamides; 3XMK78S47O / Testosterone; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; V4TKW1454M / nimesulide
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89. Ishigami K, Abu-Yousef MM, El-Zein Y: Tubular ectasia of the epididymis: a sign of postvasectomy status. J Clin Ultrasound; 2005 Dec;33(9):447-51
MedlinePlus Health Information. consumer health - Vasectomy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular ectasia of the epididymis: a sign of postvasectomy status.
  • PURPOSE: To find out if "tubular ectasia of the epididymis" is suggestive of postvasectomy status.
  • METHODS: Tubular ectasia of the epididymis is defined as enlargement of the epididymis with multiple interfaces (i.e., a speckled appearance).
  • We found 24 cases exhibiting tubular ectasia of the epididymis over a period of six years.
  • We reviewed the sonographic findings of tubular ectasia of the epididymis and evaluated the prevalence of associated findings.
  • RESULTS: In 24 patients with tubular ectasia of the epididymis, 16 cases were bilateral, five were right-sided, and three were left-sided.
  • CONCLUSION: Tubular ectasia of the epididymis is suggestive of postvasectomy epididymis.
  • [MeSH-major] Epididymis / pathology. Vasectomy / adverse effects

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 16281269.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Li Y, Putnam-Lawson CA, Knapp-Hoch H, Friel PJ, Mitchell D, Hively R, Griswold MD: Immunolocalization and regulation of cystatin 12 in mouse testis and epididymis. Biol Reprod; 2005 Nov;73(5):872-80
Hazardous Substances Data Bank. ESTRADIOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolocalization and regulation of cystatin 12 in mouse testis and epididymis.
  • The mouse Cst12 mRNA was primarily localized to the Sertoli cells in the testis and to the epithelial cells of the proximal caput region of the epididymis.
  • In this report, studies were carried out to characterize the cystatin 12 (CST12) protein in mouse testis and epididymis.
  • In the epididymis, CST12 was highly expressed in the cytoplasm of the epithelial cells in the proximal caput and secreted into the lumen.
  • The mouse CST12 protein was also detected in other regions of the epididymis; however, the localization varied greatly along the epididymal tubules.
  • Indirect immunofluorescence showed that CST12 protein was localized to the cytoplasmic droplets in both testicular and epididymal spermatozoa.
  • Northern blot analyses demonstrated that Cst12 transcript levels in the epididymis decreased after castration, and testosterone propionate (T) treatment further repressed the expression of this gene.
  • However, 17-beta estradiol (E) administration maintained the expression of Cst12 mRNA after castration, whereas treatment with both T and E failed to maintain Cst12 mRNA levels in epididymis.
  • [MeSH-major] Cystatins / metabolism. Epididymis / metabolism. Testis / metabolism

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  • (PMID = 15972886.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD 10808
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Cst12 protein, mouse; 0 / Cystatins; 0 / Recombinant Proteins; 4TI98Z838E / Estradiol
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91. Zhao YG, Shi HB, Zhang XJ, Zhou J, Men XW, Zheng XM, Hu LQ: [Effects of experimental varicocele on methylenedioxyamphetamine, total antioxidants content and sialic acid of the epididymis in adolescent rats]. Zhonghua Nan Ke Xue; 2006 Feb;12(2):154-5, 158
Hazardous Substances Data Bank. 3,4-METHYLENEDIOXYMETHAMPHETAMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effects of experimental varicocele on methylenedioxyamphetamine, total antioxidants content and sialic acid of the epididymis in adolescent rats].
  • OBJECTIVE: To explore the changes of methylenedioxyamphetamine (MDA), total antioxidants content (TAC) and sialic acid (SA) from the unilateral epididymis of experimental varicocele in adolescent rats, and to illuminate the effects of varicocele on unilateral epididymis epithelium.
  • The epididymis were collected for detecting the content of MDA, TAC and SA by using spectrophotometry.
  • CONCLUSION: The content of MDA, TAC and SA will change and the sialic acid-secreting-function of unilateral epididymis will be injured because of varicocele.
  • [MeSH-major] Antioxidants / metabolism. Epididymis / metabolism. N-Acetylneuraminic Acid / metabolism. Varicocele / metabolism

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  • (PMID = 16519155.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; GZP2782OP0 / N-Acetylneuraminic Acid; KE1SEN21RM / N-Methyl-3,4-methylenedioxyamphetamine
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92. Lee SS, Tang SH, Sun GH, Yu CP, Jin JS, Chang SY: Limited Wegener's granulomatosis of the epididymis and testis. Asian J Androl; 2006 Nov;8(6):737-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Limited Wegener's granulomatosis of the epididymis and testis.
  • A case is presented of Wegener's granulomatosis limited to the testis and epididymis, simultaneously, in a 69-year-old man.
  • Orchiectomy was carried out through an inguinal incision under the presumptive diagnosis of a right testicular tumor.
  • A hard, irregular mass occupied the upper testicle and a portion of the epididymal head was visualized.
  • Histopathologic examination of the specimen showed granulomatous inflammation of the testis and epididymis with prominent angiocentric granulomata in the walls of arteries, veins and foci of fibrinoid necrosis, surrounded by palisading inflammatory cells with a few giant cells.
  • The diagnosis of limited Wegener's granulomatosis was considered, although antineutrophil cytoplasmic antibody (c-ANCA) test was negative 2 weeks after orchiectomy.
  • [MeSH-minor] Aged. Antibodies, Antineutrophil Cytoplasmic / analysis. Epididymis. Humans. Male. Orchiectomy

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  • (PMID = 16855769.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic
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93. Sanyal SN, Sharma P, Kanwar SS: Oxidative effects of Na+--specific ionophore monensin on the rat epididymis. Drug Chem Toxicol; 2007;30(4):411-23
Hazardous Substances Data Bank. SODIUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxidative effects of Na+--specific ionophore monensin on the rat epididymis.
  • The current study has been designed to investigate the effect of monensin on spermatozoal concentration, motility, and oxidative stress-related parameters in the rat epididymis.
  • At the end of the respective treatment, the epididymis was isolated into three separate regions--the capitum, corpus, and the cauda--successively away from the head of the testis.
  • Marked changes were noted in the body weight, organ (epididymis) weight, sperm concentration and motility, as well as the morphologic observations of the sperm and the histologic architecture of the epididymal epithelium.
  • The findings of the current study indicate interactions during the spermatozoal maturational process in the epididymis, and a significant potential use of monensin in male contraception may be suggested.
  • [MeSH-major] Epididymis / drug effects. Ionophores / adverse effects. Monensin / adverse effects. Oxidative Stress / drug effects. Sodium / metabolism. Spermatozoa / drug effects

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  • Hazardous Substances Data Bank. MONENSIN .
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  • (PMID = 17934928.001).
  • [ISSN] 0148-0545
  • [Journal-full-title] Drug and chemical toxicology
  • [ISO-abbreviation] Drug Chem Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ionophores; 906O0YJ6ZP / Monensin; 9NEZ333N27 / Sodium
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94. Raymond AS, Elder B, Ensslin M, Shur BD: Loss of SED1/MFG-E8 results in altered luminal physiology in the epididymis. Mol Reprod Dev; 2010 Jun;77(6):550-63
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  • [Title] Loss of SED1/MFG-E8 results in altered luminal physiology in the epididymis.
  • In the male reproductive tract, SED1 is secreted by the initial segment of the epididymis, where it coats sperm and subsequently facilitates binding to the egg zona pellucida.
  • However, spermatic granulomas are most often manifest in the distal segments of the epididymis, whereas the bulk of SED1 is expressed in the proximal epididymis.
  • In some models, the presence of granulomas in the distal epididymis is associated with an underlying defect in the maintenance of luminal fluid homeostasis.
  • Herein, we report that SED1-null epididymal fluid is both hypo-osmotic and alkaline, relative to wildtype epididymal fluid.
  • Furthermore, the SED1-null epididymal epithelium exhibits various hallmarks of disrupted fluid reabsorption and pH regulation, including altered morphology of clear cells, increased intracellular vesicles, and apical distribution of VATPase.
  • Results indicate that the SED1-null epididymal pathologies are not the secondary consequences of defective testes or efferent ducts or of improper epididymal differentiation, unlike that seen in other epididymal models.

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  • [Copyright] Copyright 2010 Wiley-Liss, Inc.
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  • (PMID = 20422713.001).
  • [ISSN] 1098-2795
  • [Journal-full-title] Molecular reproduction and development
  • [ISO-abbreviation] Mol. Reprod. Dev.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / T32 GM08376; United States / NICHD NIH HHS / HD / R01HD23479; United States / NICHD NIH HHS / HD / HD023479-19; United States / NICHD NIH HHS / HD / R01 HD023479; United States / NICHD NIH HHS / HD / R01 HD023479-19
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / SED1 protein, mouse
  • [Other-IDs] NLM/ NIHMS208967; NLM/ PMC2896051
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95. Ichihara N, Ishikawa T, Kaseda M, Nishita T, Amasaki H, Asari M: Immunohistolocalization of carbonic anhydrase isoenzymes (CA-I, -II and -III ) in canine epididymis. J Vet Med Sci; 2006 Dec;68(12):1363-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistolocalization of carbonic anhydrase isoenzymes (CA-I, -II and -III ) in canine epididymis.
  • The immunolocalization of the efferent duct and the epididymis in canine was firstly examined using an the immunohistochemical method with the canine carbonic anhydrase (CA) -I, CA-II and CA-III antisera.
  • However, some slender shaped epithelial cells in the head and body segments of the epididymal duct were intensely reacted to the CA-II antiserum.
  • These results suggested that the CA-II might be controlled in the luminal environment in the head and body segments of the canine epididymis by the proton and bicarbonate balance for the maintenance of the spermatozoal stability and movement.

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  • (PMID = 17213711.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.- / Carbonic Anhydrase III
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96. Saradha B, Mathur PP: Induction of oxidative stress by lindane in epididymis of adult male rats. Environ Toxicol Pharmacol; 2006 Jul;22(1):90-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction of oxidative stress by lindane in epididymis of adult male rats.
  • In the present study we have sought to investigate the effect of lindane on antioxidant parameters and sialic acid levels of caput, corpus and cauda epididymis of adult male rats.
  • However, the weights of caput, corpus and cauda epididymis decreased in lindane treated animals.
  • Administration of lindane caused decrease in epididymal sperm count and motility.
  • Sialic acid levels in the epididymis decreased significantly at 5 and 50mg/kg dosage of lindane treatment.
  • In conclusion, lindane induces oxidative stress by decreasing the activities of antioxidant enzymes and sialic acid levels in the epididymis thereby causing impaired sperm function.

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  • (PMID = 21783693.001).
  • [ISSN] 1382-6689
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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97. Yeh HC, Wu WJ, Lee YC, Chang TH, Huang CH, Li CC: Leiomyoma of the epididymis: a case report. Kaohsiung J Med Sci; 2006 Oct;22(10):519-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyoma of the epididymis: a case report.
  • Tumors of the epididymis, both primary and secondary, and whether benign or malignant, are very rare.
  • Adenomatoid tumors and leiomyoma are the most frequently diagnosed benign tumors of the epididymis.
  • In a review of the American and European literature, leiomyoma was the second most common neoplasm of the epididymis, representing 6% of primary epididymal tumors.
  • A case of leiomyoma of the epididymis in a 53-year-old patient is reported.
  • There were no bother some symptoms except gradual enlargement of the tumor.
  • A fresh frozen section showed a benign lesion, and conservative excision of the tumor was performed without any difficulty.
  • [MeSH-major] Epididymis. Genital Neoplasms, Male / pathology. Leiomyoma / pathology. Scrotum

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  • (PMID = 17098685.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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98. Zhang L, Hu Z, Zhu C, Liu Q, Zhou Y, Zhang Y: Identification and characterization of an epididymis-specific gene, Ces7. Acta Biochim Biophys Sin (Shanghai); 2009 Oct;41(10):809-15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification and characterization of an epididymis-specific gene, Ces7.
  • Here, a novel rat epididymis-specific gene named Ces7 was cloned and characterized.
  • It was a novel member of CE family, which was mainly expressed and secreted to the lumens of the corpus and cauda epididymis.
  • [MeSH-major] Carboxylesterase / genetics. Epididymal Secretory Proteins / genetics. Epididymis / enzymology. Sperm Maturation / genetics

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  • (PMID = 19779645.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Epididymal Secretory Proteins; EC 3.1.1.1 / Carboxylesterase
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99. Hisatomi A, Sakuma S, Fujiwara M, Seki J: Effect of tacrolimus on the cauda epididymis in rats: analysis of epididymal biochemical markers or antioxidant defense enzymes. Toxicology; 2008 Jan 14;243(1-2):23-30
Hazardous Substances Data Bank. L-CARNITINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of tacrolimus on the cauda epididymis in rats: analysis of epididymal biochemical markers or antioxidant defense enzymes.
  • The effect of tacrolimus on epididymal biochemical markers was investigated following single daily subcutaneous doses of 1, 2 and 3 mg kg(-1) day(-1) for 2 weeks to male adult rats.
  • The tacrolimus 2 and 3 mg kg(-1) day(-1) groups showed a significant and dose-dependent decrease in sperm count in the cauda epididymis.
  • Among tissue levels of L-carnitine, alpha-glucosidase and acid phosphatase, only L-carnitine level in the cauda epididymis was significantly reduced in the tacrolimus 3 mg kg(-1)day(-1) group.
  • It was suggested that lowering of L-carnitine in the cauda epididymis was attributable to the adverse effect on epididymal function to transport and/or concentrate L-carnitine.
  • Since L-carnitine has been reported to have antioxidant potential, antioxidant defense enzymes in the cauda epididymis such as superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase were evaluated.
  • In conclusion, this study indicates that tacrolimus induces a decrease in L-carnitine level in the cauda epididymis, which is probably caused by impairment of epididymal function to transport and/or concentrate L-carnitine from bloodstream, and a decrease in sperm count.
  • [MeSH-major] Antioxidants / metabolism. Carnitine / metabolism. Epididymis. Immunosuppressive Agents / adverse effects. Tacrolimus / adverse effects

  • MedlinePlus Health Information. consumer health - Antioxidants.
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  • (PMID = 17988778.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Biomarkers; 0 / Immunosuppressive Agents; EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; EC 1.8.1.7 / Glutathione Reductase; S7UI8SM58A / Carnitine; WM0HAQ4WNM / Tacrolimus
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100. Yuan Q, Guo QS, Cornwall GA, Xu C, Wang YF: Age-dependent expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis. Asian J Androl; 2007 May;9(3):305-11
MedlinePlus Health Information. consumer health - Seniors' Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age-dependent expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis.
  • AIM: To investigate the spatial and temporal expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis during postnatal development.
  • METHODS: The QuantiGene assay and indirect immunofluorescence technique were used to examine the Cres mRNA and Cres protein level in mouse testis and epididymis on postnatal days 14, 20, 22, 28, 35, 49, 70 and 420. RESULTS:.
  • (1) In both the testis and epididymis, Cres mRNA was first detected on day 20, then it increased gradually from day 20 to day 70, and the high expression level maintained till day 420. (2) In the testis, the Cres protein was exclusively localized to the elongating spermatids and was first detected on day 22.
  • From day 49 to day 420, the number of Cres-positive cells was almost stable. (3) The Cres protein was first detected on day 20 in the proximal caput epididymal epithelium.
  • Moreover, the luminal fluid of the midcaput epididymis was also stained Cres-positive from day 35 on.
  • No Cres-positive staining was observed in distal caput, corpus and cauda epididymis throughout.
  • CONCLUSION: The Cres gene displays a specific age-dependent expression pattern in mouse testis and epididymis on both the mRNA and protein level.
  • [MeSH-major] Aging / genetics. Cystatins / genetics. Epididymis / metabolism. Gene Expression Regulation, Developmental. Testis / metabolism

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  • (PMID = 17486270.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cystatins; 0 / RNA, Messenger; 149291-61-2 / Cst8 protein, mouse
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