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Items 1 to 48 of about 48
1. Nishikawa Y, Kaneko T, Takiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D: Dermoscopy of eccrine poroma with calcification. J Dermatol Case Rep; 2009 Nov 28;3(3):38-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopy of eccrine poroma with calcification.
  • BACKGROUND: Eccrine poromas are relatively common slow-growing benign solitary adnexal tumors originating from the intraepidermal portion of the eccrine sweat duct (acrosyringium).
  • Dystrophic calcification is rarely found in lesions of eccrine poroma, and only 2 cases of eccrine poroma with calcification have been reported thus far.
  • In the present report, we describe another case of eccrine poroma with calcification occurring in the palm of the hand.
  • MAIN OBSERVATIONS: A 73-year-old man with hemiparesis, who had a 10-year history of tumor on his right palm, which was occasionally injured by a walking crutch, causing bleeding and ulceration.
  • Physical examination revealed a pigmented dome-shaped tumor.
  • Histological examination revealed that the tumor was composed of cords of tumor cells extending from the epidermis into the dermis.
  • The tumor showed cystic structures and calcification.
  • The patient was diagnosed with Pinkus-type eccrine poroma on the basis of histological findings.
  • CONCLUSIONS: Although cutaneous neoplasms commonly associated with calcification are of follicular origin, it is known that dystrophic calcification may be triggered also in tumors of eccrine origin by multiple factors, including mechanical injury.
  • Dermoscopy may be helpful in establishing clinical diagnosis of calcified eccrine poromas.

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  • [Cites] Br J Dermatol. 2001 Jan;144(1):146-50 [11167697.001]
  • [Cites] Dermatol Surg. 2003 Oct;29(10):1076-9 [12974711.001]
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  • (PMID = 21886728.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157797
  • [Keywords] NOTNLM ; Pinkus type / adnexal tumors / calcification / dermoscopy / eccrine gland / local tissue injury
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2. Al Baghli A, Reddy SS, Reddy MA: Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. Middle East Afr J Ophthalmol; 2010 Oct;17(4):374-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.
  • The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.

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  • (PMID = 21180442.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2991459
  • [Keywords] NOTNLM ; Eccrine Glands / Nodular Hidradenoma / Sweat Gland Tumor
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3. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In our routine practice, we observed that CD23 reacted strongly with eccrine and apocrine secretory coils.
  • METHODS: Immunohistochemical staining of CD23 was performed in a total of 131 cases of apocrine, eccrine, follicular and other cutaneous non-lymphoid tumors.
  • RESULTS: CD23 expression was detected in all benign apocrine tumors and in half of benign eccrine tumors, particularly those derived from secretory coils.
  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • In addition, CD23 reacted diffusely with cutaneous mucinous eccrine carcinoma in a manner similar to breast or colonic adenocarcinoma.
  • CONCLUSION: CD23 appears to be a reliable immunohistochemical marker of the eccrine/apocrine secretory coil and helpful in identifying sweat gland tumors of such origin.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Apocrine Glands / metabolism. Apocrine Glands / pathology. Eccrine Glands / metabolism. Eccrine Glands / pathology. Humans

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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4. Jamalipour M, Heidarpour M, Rajabi P: Generalized eruptive syringomas. Indian J Dermatol; 2009;54(1):65-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Generalized eruptive syringoma is a rare clinical presentation of a benign adnexal tumor that derives from the intraepidermal portion of the eccrine sweat ducts.
  • Treatment of this benign condition is cosmetic only.

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  • [Cites] Dermatol Online J. 2005;11(3):34 [16409930.001]
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  • (PMID = 20049275.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2800876
  • [Keywords] NOTNLM ; Generalized eruptive syringoma / eccrine ducts / papules
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5. Missall TA, Burkemper NM, Jensen SL, Hurley MY: Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol; 2009 Feb;36(2):190-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical differentiation of four benign eccrine tumors.
  • BACKGROUND: The histogenesis and differentiation of eccrine tumors, including cylindroma, poroma, spiradenoma and syringoma, remains controversial.
  • METHODS: Ten examples each of normal eccrine structures and of four benign eccrine tumors are analyzed with antibodies to cytokeratin (CK) 7, CD34, CK6, CK10, smooth muscle actin (SMA) and CD10.
  • These markers represent two different immunohistochemical stains for each part of the eccrine structure; CK7 and CD34 stain the secretory coil, CK6 and CK10 stain the straight duct and SMA and CD10 stain the myoepithelial cells.
  • This redundancy in staining is performed on four benign eccrine tumors to better interpret the existing literature.
  • SMA appears to be a more specific marker for myoepithelial cells surrounding normal eccrine coils, and none of the studied tumors express SMA or CD10.
  • CONCLUSIONS: Our studies suggest that syringomas are tumors of the eccrine duct, while cylindromas and spiradenomas are tumors of the secretory coil.
  • [MeSH-major] Adenoma, Sweat Gland. Antigens, CD34 / biosynthesis. Biomarkers, Tumor / biosynthesis. Keratins / biosynthesis. Neprilysin / biosynthesis. Sweat Gland Neoplasms / metabolism

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  • (PMID = 18564284.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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6. Morganti AG, Martone FR, Macchia G, Carbone A, Massi G, De Ninno M, Deodato F, Picardi V, Sallustio G, Tulli A, Amerio P: Eccrine syringofibroadenoma radiation treatment of an unusual presentation. Dermatol Ther; 2010 Jan-Feb;23 Suppl 1:S20-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine syringofibroadenoma radiation treatment of an unusual presentation.
  • Benign skin diseases have seldom been treated with radiotherapy, unless resistant to other treatments.
  • Eccrine syringofibroadenoma (ESFA) is a rare benign eccrine tumor.
  • [MeSH-major] Eccrine Glands. Fibroadenoma / radiotherapy. Foot Diseases / radiotherapy. Sweat Gland Neoplasms / radiotherapy. Syringoma / radiotherapy

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  • (PMID = 20136917.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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7. Brown CW Jr, Dy LC: Eccrine porocarcinoma. Dermatol Ther; 2008 Nov-Dec;21(6):433-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma.
  • Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase.
  • This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Humans. Lymphatic Metastasis. Mohs Surgery. Neoplasm Invasiveness. Neoplasm Staging. Sentinel Lymph Node Biopsy

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  • (PMID = 19076620.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 53
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8. Teixeira M, Ferreira M, Machado S, Alves R, Selores M: Eruptive syringomas. Dermatol Online J; 2005;11(3):34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eruptive syringoma is a rare clinical presentation of a benign tumor of the eccrine ducts.
  • It consists in successive crops of small skin-colored papules on the anterior body surfaces.
  • Treatment of this benign condition is cosmetic only.

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  • (PMID = 16409930.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Al-Ahwal MS, Sawan AS, Zimmo SK: Malignant eccrine poroma. Saudi Med J; 2005 May;26(5):859-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine poroma.
  • Benign eccrine poroma arises from the intraepidermal portion of the eccrine gland duct.
  • We report a 44-year-old male patient who presented primarily with a lesion diagnostic of benign eccrine poroma of the right foot sole with no clear evidence of malignancy, which was incompletely excised, followed 5 months later by local recurrence, ulceration, occasional bleeding and right inguinal lymphadenopathy.
  • Incomplete excision of the primary tumor as well as excision of a skin lesion on the right knee joint revealed malignant eccrine poroma with aggressive histology, lymphovascular and perineural invasion.
  • This tumor might be malignant at the first presentation, which was not confirmed histopathologically considering the short duration of only 5 months for malignant transformation.
  • The management of metastatic malignant eccrine poroma is difficult.

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  • [CommentIn] Saudi Med J. 2005 Oct;26(10):1665; author reply 1665 [16228085.001]
  • (PMID = 15951884.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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10. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dermoscopic features of eccrine poroma].
  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.
  • The dermoscopic features of pigmented and nonpigmented eccrine poroma have recently been described.
  • We present 2 cases of eccrine poroma, with their dermoscopic features.
  • Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin Neoplasms / diagnosis

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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11. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine spiradenoma of the scalp.
  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • The tumor with its large subcutaneous extension and the outer table of the cranium were removed.
  • A split-thickness skin graft was applied on the exposed inner table.
  • At 24 months' follow-up, there has been no tumor recurrence.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • Also, we review the existing literature on malignant eccrine spiradenoma of the scalp.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation

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  • (PMID = 19098562.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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12. Oh JG, Yoon CH, Lee CW: Case of Cowden syndrome associated with eccrine angiomatous hamartoma. J Dermatol; 2007 Feb;34(2):135-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of Cowden syndrome associated with eccrine angiomatous hamartoma.
  • A 47-year-old woman had a skin-colored plaque on the left foot.
  • Physical examinations revealed macrocephaly, multiple papules of the buccal mucosa, skin tags of the neck and multiple keratotic papules of both hands.
  • Histological examination of the skin lesion on the left foot showed an increased numbers of eccrine sweat glands and blood vessels, which are characteristic histological findings of eccrine angiomatous hamartoma (EAH), a rare benign tumor.
  • [MeSH-major] Eccrine Glands. Hamartoma Syndrome, Multiple / pathology. Hemangioma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17239153.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Langbein L, Cribier B, Schirmacher P, Praetzel-Wunder S, Peltre B, Schweizer J: New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma. Br J Dermatol; 2008 Sep;159(3):633-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma.
  • BACKGROUND: Peripheral and luminal layers of eccrine sweat gland ducts are self-renewing structures.
  • OBJECTIVES: To investigate the expression of luminal (K77), peripheral (K1) and further discriminatory keratins in two eccrine sweat gland tumours: syringoma, thought to show differentiation towards luminal cells of intraepidermal sweat ducts and eccrine poroma, considered to arise from poroid cells, i.e. peripheral duct cells; and keratinocytes of the lower acrosyringium/sweat duct ridge differentiating towards cells of intradermal/intraepidermal duct segments.
  • In eccrine poroma epidermal keratins K5/K14 were ubiquitously expressed in all poroid cells.
  • CONCLUSIONS: Syringomas are benign tumours of luminal cells of the lowermost intraglandular sweat duct.
  • [MeSH-major] Adenoma, Sweat Gland / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Keratin-1 / analysis. Sweat Gland Neoplasms / chemistry

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  • (PMID = 18647305.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT1 protein, human; 0 / KRT77 protein, human; 0 / Keratin-1
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14. Rodríguez-Martín M, Sánchez González R, Sáez-Rodríguez M, García-Bustínduy M, Martín-Herrera A, Noda-Cabrera A: An unusual case of congenital linear eccrine spiradenoma. Pediatr Dermatol; 2009 Mar-Apr;26(2):180-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual case of congenital linear eccrine spiradenoma.
  • Eccrine spiradenoma (ES) is a benign uncommon tumor of skin adnexa with a characteristic clinical and histopathological presentation.
  • [MeSH-major] Adenoma, Sweat Gland / congenital. Eccrine Glands / pathology. Neoplasms, Multiple Primary / congenital. Sweat Gland Neoplasms / congenital

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  • (PMID = 19419467.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Schadt CR, Boyd AS: Eccrine syringofibroadenoma with co-existent squamous cell carcinoma. J Cutan Pathol; 2007 Dec;34 Suppl 1:71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine syringofibroadenoma with co-existent squamous cell carcinoma.
  • Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals.
  • Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells.
  • The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts.
  • The co-existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17997744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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16. Lee HW, Han SS, Kang J, Lee MW, Choi JH, Moon KC, Koh JK: Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? J Cutan Pathol; 2006 Apr;33(4):323-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor?
  • Eccrine angiomatous hamartoma (EAH) is a rare, benign condition characterized histologically by increased numbers of eccrine elements, as well as numerous capillary channels.
  • We report a 35-year-old female patient with multiple, sudoriparous, subcutaneous nodules on the right foot, which showed typical histopathological findings of EAH, and vascular components of the tumor consisted of thin-walled dilated vascular spaces intermixed with spindle cells and some histiocytoid endothelial cells representing spindle cell hemangioma (SCH).
  • [MeSH-major] Eccrine Glands / pathology. Foot. Hamartoma / diagnosis. Hemangioma / diagnosis. Neoplasms, Connective and Soft Tissue / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16630186.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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17. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations.
  • Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in areas with a high density of eccrine sweat glands, like the palms or soles.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • OBSERVATIONS: We report 5 cases of eccrine porocarcinoma of the head.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Only after histopathologic examination were they classified as eccrine porocarcinoma, showing features of epithelial tumors with abortive ductal differentiation.
  • Characteristic clinical, histopathologic and immunohistochemical findings of eccrine porocarcinomas are illustrated.
  • CONCLUSION: Eccrine porocarcinomas are potentially fatal adnexal malignancies, in which extensive metastatic dissemination may occur.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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18. Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, Chatti S: Malignant eccrine spiradenoma: a new case report. J Cutan Pathol; 2010 Apr;37(4):478-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine spiradenoma: a new case report.
  • Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin.
  • In most cases, it arises in pre-existing benign eccrine spiradenoma.
  • We report an additional case of malignant eccrine spiradenoma.
  • The present case is of a 75-year-old man with malignant eccrine spiradenoma developed in the right shoulder.
  • The gross pathologic specimen showed a large cutaneous and subcutaneous multinodular tumor, measuring 6 cm in maximal dimension.
  • Microscopically, there were two distinct morphological components: a benign eccrine spiradenoma and a malignant eccrine spiradenoma of low grade with extensive necrosis.
  • Morphological differentiation in malignant eccrine spiradenoma is variable, sometimes with almost complete loss of eccrine differentiation.
  • Extensive sampling to look for a probable previously benign component is necessary.
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19614990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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19. Naik V, Arsenovic N, Reed M: Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma. Dermatol Online J; 2009;15(9):6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma.
  • Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous tumor characterized by proliferation of the eccrine gland elements closely associated with capillary angiomatosis and proliferation of other dermal elements, such as adipose tissue, hair and epidermis.
  • Eccrine angiomatous hamartoma is usually sporadic, but one familial case of the multifocal variant has been reported.
  • Eccrine angiomatous hamartoma is generally asymptomatic but may occasionally be associated with pain and hyperhidrosis.
  • Eccrine angiomatous hamartoma is a benign slowly growing lesion for which aggressive treatment is not indicated.
  • [MeSH-major] Eccrine Glands / pathology. Hamartoma / diagnosis. Sweat Gland Diseases / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Friction. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Nevus, Blue / diagnosis. Skin / injuries. Skin Neoplasms / diagnosis

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  • (PMID = 19930993.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Goh SG, Dayrit JF, Calonje E: Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature. J Cutan Pathol; 2007 Jan;34(1):55-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature.
  • Eccrine porocarcinoma is an uncommon sweat gland malignancy.
  • We present two cases of sarcomatoid eccrine porocarcinoma associated with a benign poroma.
  • Case 1 pertained to an 82-year-old woman with an ulcerated chest wall tumor, and Case 2 was that of a 74-year-old woman who presented with an ulcerated plaque in the lower leg.
  • In both the cases, benign poromatous elements were histologically evident.

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  • (PMID = 17214856.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Carcinoembryonic Antigen; 0 / Mucin-1; 68238-35-7 / Keratins
  • [Number-of-references] 31
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21. Garnacho Saucedo GM, Moreno Jiménez JC, Jiménez Puya R, Rodríguez Bujaldon A: Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas. Dermatol Ther; 2010 Jan-Feb;23(1):94-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas.
  • Eccrine hidrocystoma is a benign tumor derived from eccrine sudoriparous glands.
  • Most eccrine hidrocystomas are solitary and asymptomatic lesions.
  • This report describes the successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week.
  • Multiple eccrine hidrocystomas are a rare condition and, to date, no effective treatment has been reported.
  • [MeSH-minor] Administration, Cutaneous. Eccrine Glands / pathology. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 20136914.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Muscarinic Antagonists; V92SO9WP2I / Glycopyrrolate
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22. Tanaka Y, Bhunchet E, Shibata T: A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. Breast Cancer; 2008;15(2):175-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of malignant eccrine spiradenoma metastatic to intramammary lymph node.
  • Eccrine spiradenoma (ES) is a fairly common, benign, cutaneous tumor originating from the sweat glands.
  • In contrast, the malignant counterpart of ES, malignant eccrine spiradenoma (MES), is extremely rare.
  • We present the first reported case of this tumor metastasizing to an intramammary lymph node (IMLN).

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  • (PMID = 18270794.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • No staining was seen in eccrine gland cells.
  • No staining was seen in eccrine poromas, eccrine spiradenomas, and syringomas.
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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24. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • Recent immunohistochemical studies of these two tumors have provided compelling evidence that these two tumors may merely represent a single tumor type with a spectrum of histological features.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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25. Collman DR, Blasko M, Alonzo J, Stess R: Clear cell hidradenoma of the ankle. J Foot Ankle Surg; 2007 Sep-Oct;46(5):387-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell hidradenoma is a relatively common, benign eccrine neoplasm with rare presentations in the foot and ankle.
  • Variable clinical and histopathologic characteristics of the tumor warrant careful consideration over primary and recurrent malignancy, particularly eccrine carcinoma.
  • The first known case of primary benign clear cell hidradenoma of the ankle is presented with imaging studies, surgical management, and clinicopathologic correlation, distinguishing the neoplasm from its malignant counterparts.

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  • (PMID = 17761324.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities.
  • METHODS: We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal neoplasms.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • CK15 and nestin expression were noted in 11 of 23 (48%) and 7 of 23 (30%) cases in the malignant group, respectively (6 microcystic adnexal carcinoma, 7 porocarcinoma, and 9 eccrine carcinoma).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry

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  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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27. Marzano AV, Fiorani R, Girgenti V, Crosti C, Alessi E: Familial syringoma: report of two cases with a published work review and the unique association with steatocystoma multiplex. J Dermatol; 2009 Mar;36(3):154-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringoma is a benign neoplasm of eccrine origin.
  • Clinically, it manifests as small skin-colored to yellowish soft papules usually localized around the eyes and on the upper cheeks of middle-aged women.
  • In the latter, steatocystoma multiplex, which is regarded as a benign cystic neoplasm of the folliculosebaceous unit or a nevoid malformation differentiated in the direction of the sebaceous duct, was associated.

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  • (PMID = 19335690.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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28. Hong SK, Lee HJ, Cho SH, Seo JK, Lee D, Sung HS: Syringomas Treated by Intralesional Insulated Needles without Epidermal Damage. Ann Dermatol; 2010 Aug;22(3):367-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringoma is a benign adnexal tumor derived from intradermal eccrine ducts; it predominantly occurs in women at puberty or later in life.
  • Although syringoma is a common benign neoplasm, there have been no effective therapies for its removal.

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  • [Cites] Dermatol Surg. 2007 Mar;33(3):310-3 [17338688.001]
  • [Cites] J Clin Pathol. 2007 Feb;60(2):145-59 [16882695.001]
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  • (PMID = 20711282.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917699
  • [Keywords] NOTNLM ; Insulated needle / Syringoma
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29. Martínez Luna E, Rebollo Domínguez N, Vega Memije ME, Arenas R: [Vulvar syringoma: a report of two cases]. Ginecol Obstet Mex; 2006 May;74(5):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringoma is a benign neoplasm of eccrine origin.
  • Syringomas involving the genitalia are rare, they present as multiple, bilateral, skin-colored papules over the labia majora.

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  • (PMID = 16972525.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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30. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • By far the most common composite tumor was spiradenocylindroma.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F: Giant clear cell hidradenoma of the knee. J Cutan Pathol; 2010 Sep;37(9):e37-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension.
  • The tumor was mobile, located above the patellar tendon and was without bony involvement on imaging studies.
  • Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall.
  • Microscopically, the tumor cells showed an infiltrative growth pattern at the periphery, however, the tumor cytology was bland and no necrosis or mitoses were identified.
  • Immunohistochemically, tumor cells were positive for cytokeratin, CAM5.2, p53, carcino-embryonic antigen (CEA) and epithelial membrane antigen (EMA), and negative for CD10 and Ki-67.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney Neoplasms / diagnosis. Knee. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19615032.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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32. Skoro M, Ostović KT, Cikara I, Müller D, Novak NP, Virag M: Fine needle aspiration cytology of chondroid syringoma. Coll Antropol; 2010 Jun;34(2):687-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma (CS) is a rare, benign, appendageal tumor with diagnostic feature of myxochondroid stroma supporting eccrine and apocrine epithelial structures.

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  • (PMID = 20698155.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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33. Weinreb I, O'Malley F, Ghazarian D: Ectopic hamartomatous thymoma: a case demonstrating skin adnexal differentiation with positivity for epithelial membrane antigen, androgen receptors, and BRST-2 by immunohistochemistry. Hum Pathol; 2007 Jul;38(7):1092-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic hamartomatous thymoma: a case demonstrating skin adnexal differentiation with positivity for epithelial membrane antigen, androgen receptors, and BRST-2 by immunohistochemistry.
  • Ectopic hamartomatous thymoma is a rare tumor of the lower neck occurring in adult men, which follows a benign course.
  • The origin of this tumor has been debated, but it is now believed to arise from remnants of the cervical sinus of His from early development.
  • We describe a case of ectopic hamartomatous thymoma with typical features, as well as multifocal areas of skin adnexal differentiation.
  • These included sebaceous, eccrine, and apocrine elements.
  • Epithelial membrane antigen stained sebaceous cells and the luminal borders of eccrine and apocrine ducts.
  • [MeSH-major] Carrier Proteins / metabolism. Glycoproteins / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / diagnosis. Receptors, Androgen / metabolism. Thymoma / diagnosis

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  • (PMID = 17574947.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Mucin-1; 0 / PIP protein, human; 0 / Receptors, Androgen
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34. Zembowicz A, Garcia CF, Tannous ZS, Mihm MC, Koerner F, Pilch BZ: Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. Am J Surg Pathol; 2005 Oct;29(10):1330-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Calponin, smooth muscle actin, and p63 immunohistochemical stains did not disclose myoepithelial cells around larger tumor nests in most cases, supporting the notion that EMPSGC is an invasive carcinoma.
  • In 10 cases, cystic areas lined by benign epithelium indistinguishable from eccrine ducts were present.
  • In some foci, the benign ductal epithelium was undermined or replaced by carcinoma in situ with similar cytologic features to the solid or papillary areas of EMPSGC.
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cheek / pathology. Eyelid Neoplasms / metabolism. Eyelid Neoplasms / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16160476.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Gündüz K, Demirel S, Heper AO, Günalp I: A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. Surv Ophthalmol; 2006 May-Jun;51(3):280-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We performed excisional biopsy of the lesion and lateral advancement skin flap for reconstruction of the skin defect.
  • Histopathologic and immunohistochemical findings were consistent with atypical chondroid syringoma with eccrine differentiation.
  • Chondroid syringoma is a rare skin tumor that occurs, very rarely, in the eyelids, especially the lower eyelid.
  • Chondroid syringomas are classified as two types, the apocrine type characterized by tubular and cystic branching lumina lined by two layers of epithelial cells, and the eccrine type, which has small tubular lumina lined by a single layer of epithelial cells.
  • The tumor can have benign, atypical, and malignant variants.
  • Our patient had the atypical variant, which is characterized by benign cytological features, as well as the presence of infiltrative margins and/or satellite nodules.
  • Even benign chondroid syringomas, if incompletely excised, can recur with malignant transformation; thus, complete excision and regular follow-up is recommended for all chondroid syringomas.

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  • (PMID = 16644368.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. de Koning HD, Bovenschen HJ: Two adjacent nodules on the leg. Dermatol Online J; 2010;16(6):13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma.
  • Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor.

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  • (PMID = 20579468.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Chen CC, Chang YT, Liu HN: Clinical and histological characteristics of poroid neoplasms: a study of 25 cases in Taiwan. Int J Dermatol; 2006 Jun;45(6):722-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine poroma (EP) are relatively common benign eccrine neoplasms.
  • Other poroid neoplasms (PNs), namely hidroacanthoma simplex (HS), dermal duct tumor (DDT), and poroid hidradenoma (PH), are seldom reported.
  • [MeSH-major] Skin Neoplasms / pathology. Sweat Gland Diseases / pathology

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  • (PMID = 16796636.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Kruse AL, Zwahlen R, Bredell MG, Riener MO, Grätz KW: Apocrine hidrocystoma of the cheek. J Craniofac Surg; 2010 Mar;21(2):594-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Apocrine hidrocystoma is an uncommon benign cystic proliferation of the apocrine sweat glands.
  • Malignant melanoma, eccrine hidrocystoma, angioma, and follicular cysts have to be considered as differential diagnoses.
  • An exocrine tumor or, more unlikely, a melanoma was considered as a differential diagnosis.
  • CONCLUSIONS: This benign lesion can be excised by a narrow margin.
  • Therefore, knowledge of this benign entity in head and neck surgery including the differential diagnosis can prevent an unnecessarily large defect by too large margins.
  • [MeSH-minor] Diagnosis, Differential. Follicular Cyst / diagnosis. Hemangioma / diagnosis. Humans. Male. Melanoma / diagnosis. Middle Aged. Skin Diseases / diagnosis

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  • (PMID = 20489460.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • The PubMed database was searched for reported cases of syringocystadenoma papilliferum of the eyelid (keywords: syringocystadenoma, eyelid, apocrine, eccrine).
  • Nine lesions (64%) were associated with apocrine, eccrine, or sebaceous tumors or malformations.
  • None of the lesions was associated with a malignant neoplasm.
  • CONCLUSIONS: Syringocystadenoma papilliferum can rarely affect eyelid skin.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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40. Hatta N, Hirano T, Kimura T, Hashimoto K, Mehregan DR, Ansai S, Takehara K, Takata M: Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol; 2005 Feb;32(2):131-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
  • BACKGROUND: Distinguishing basal cell carcinoma (BCC) from other benign and malignant skin tumors is sometimes a difficult task for the pathologists.
  • METHODS: Gli1 transcript levels were measured by real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissues of 68 cases of various skin tumors.
  • The tumors included BCC (21), squamous cell carcinoma (13), seborrheic keratoses (8), trichoepithelioma (5), eccrine poroma/porocarcinoma (4), and sebaceous epithelioma/carcinoma (2).
  • CONCLUSIONS: Quantification of Gli1 transcripts by RT-PCR is helpful in discriminating BCC and trichoepithelioma from other skin tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Oncogene Proteins / metabolism. Skin Neoplasms / diagnosis. Transcription Factors / metabolism

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  • (PMID = 15606671.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gli protein; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / Transcription Factors
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41. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It can be classified as eccrine and apocrine according to its pathological characteristics.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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43. Lee MH, Kim NR, Ryu JA: Cyst-like solid tumors of the musculoskeletal system: an analysis of ultrasound findings. Skeletal Radiol; 2010 Oct;39(10):981-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twenty-three masses were identified, of which initial interpretation on gray scale included cystic tumor which pathology revealed to be solid tumors.
  • RESULTS: Of 23 masses, there were 5 giant cell tumors of the tendon sheath, 4 schwannomas, 3 vascular leiomyomas, 2 benign fibrous histiocytomas, 2 dermatofibrosarcoma protuberans, 2 granular cell tumors, 1 dermatofibroma, 1 fibroma of the tendon sheath, 1 fibromatosis, 1 eccrine spiradenoma, and 1 granulation tissue.

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  • (PMID = 20186412.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
  • The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge.
  • The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary skin tumors vs. cutaneous metastases of carcinomas from internal organs.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).
  • Sensitivity, specificity, and positive and negative predictive values of podoplanin and p63 immunoreactivity to separate primary skin neoplasms from metastatic carcinomas were 78.4, 100.0, 100.0 and 84.0% for podoplanin, respectively, and 100.0, 100.0, 100.0 and 100.0% for p63, respectively.
  • The differences in p63 and podoplanin immunohistochemical expression between primary skin tumors and metastatic carcinomas to the skin were statistically significant (p < 0, 0001).
  • The results of our study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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45. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • The commonest variants are those of eccrine sweat gland origin.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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46. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • Overlying skin was normal, and the swelling was fixed to the skin but freely mobile over underlying structure.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Gencoglan G, Karaarslan IK, Dereli T, Kazandi AC: Dermatofibroma on the palmar surface of the hand. Skinmed; 2008 Jan-Feb;7(1):41-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This was a firm and nontender lesion that was fixed to the overlying skin but moved freely from underlying structures.
  • The firm and nontender lesion was fixed to the overlying skin but moved freely from underlying structures (Figure B).
  • Clinical examination revealed a 0.6-cm, well-circumscribed nodule, with a dome shape and colored skin.
  • Clinically, the nodular lesion appeared to be a benign tumor (Figure C).
  • The subcutaneous fat and adjacent skin were normal.
  • No folliculosebaceous units at the periphery of the lesion were seen, but a few eccrine sweet glands were noted.
  • [MeSH-major] Dermatofibrosarcoma / pathology. Hand Dermatoses / pathology. Skin Neoplasms / pathology

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  • (PMID = 18174803.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Al-Qattan MM, Al-Turaiki TM, Al-Oudah N, Arab K: Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity. J Hand Surg Eur Vol; 2009 Jun;34(3):402-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity.
  • [MeSH-minor] Disease Progression. Humans. Male. Middle Aged. Nails. Thumb. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19457912.001).
  • [ISSN] 2043-6289
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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