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1. D'Andrea MR, Derian CK, Santulli RJ, Andrade-Gordon P: Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol; 2001 Jun;158(6):2031-41
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  • [Title] Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues.
  • We investigated the presence of PAR-1 and PAR-2 in human normal, benign and malignant tissues using immunohistochemistry and in situ hybridization.
  • Most notably, an up-regulation of PAR-1 and PAR-2 observed in proliferating, smooth muscle actin (SMA)-positive stromal fibroblasts surrounding the carcinoma cells was not observed in normal or benign conditions.
  • Furthermore, in vitro studies using proliferating, SMA-positive, human dermal fibroblasts, and scrape-wounded human dermal fibroblasts demonstrated the presence of PAR-1 and PAR-2 not detected in quiescent, SMA-negative cultures.
  • [MeSH-minor] Actins / analysis. Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Carcinoma / genetics. Carcinoma / metabolism. Cell Division. Cells, Cultured. Female. Humans. Immunohistochemistry. In Situ Hybridization. RNA, Messenger / biosynthesis. RNA, Neoplasm / biosynthesis. Receptor, PAR-1. Receptor, PAR-2

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  • (PMID = 11395381.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, PAR-1; 0 / Receptor, PAR-2; 0 / Receptors, Thrombin
  • [Other-IDs] NLM/ PMC1891970
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2. Schön M, Klein CE, Hogenkamp V, Kaufmann R, Wienrich BG, Schön MP: Basal-cell adhesion molecule (B-CAM) is induced in epithelial skin tumors and inflammatory epidermis, and is expressed at cell-cell and cell-substrate contact sites. J Invest Dermatol; 2000 Dec;115(6):1047-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In normal skin, B-CAM was expressed by endothelial cells of dermal blood vessels.
  • In contrast, B-CAM was strongly upregulated within the tumor tissue of both malignant and benign epithelial skin tumors, including basal cell carcinomas, squamous cell carcinomas, keratoacanthomas, and common warts.
  • Halting proliferation of transformed keratinocytes through cytostatic drugs resulted in decreased B-CAM synthesis.
  • [MeSH-major] Carcinoma / metabolism. Cell Adhesion Molecules / biosynthesis. Cell Communication / physiology. Dermatitis / metabolism. Neoplasm Proteins / biosynthesis. Skin Neoplasms / metabolism

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  • [CommentIn] J Invest Dermatol. 2001 Oct;117(4):995-7 [11676846.001]
  • (PMID = 11121140.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / BCAM protein, human; 0 / Cell Adhesion Molecules; 0 / Lutheran Blood-Group System; 0 / Neoplasm Proteins
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