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1. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med; 2008;4:18
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  • [Title] Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma.
  • BACKGROUND: A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis.
  • Diagnosis is often delayed due to its variable and often benign clinical appearance.
  • Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma.
  • [MeSH-major] Facial Neoplasms / pathology. Hemangiosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18694495.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2533304
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2. Massi D, Landriscina M, Piscazzi A, Cosci E, Kirov A, Paglierani M, Di Serio C, Mourmouras V, Fumagalli S, Biagioli M, Prudovsky I, Miracco C, Santucci M, Marchionni N, Tarantini F: S100A13 is a new angiogenic marker in human melanoma. Mod Pathol; 2010 Jun;23(6):804-13
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  • Angiogenesis is critical in melanoma progression and metastasis and relies on the synthesis and release of proangiogenic molecules such as vascular endothelial growth factor (VEGF)-A and fibroblast growth factors (FGFs).
  • S100A13 is upregulated in astrocytic gliomas, in which it correlates with VEGF-A expression, microvessel density and tumor grading, and promotes a more aggressive, invasive phenotype in lung cancer-derived cell lines.
  • To investigate the involvement of S100A13 in human cutaneous melanoma, we analyzed a series of 87 cutaneous melanocytic lesions: 14 common acquired melanocytic nevi, 14 atypical, so-called 'dysplastic' nevi, 45 melanomas (17 radial growth phase and 28 vertical growth phase) and 14 melanoma metastases.
  • We found that S100A13 was expressed in melanocytic lesions; compared with benign nevi, S100A13 protein expression was significantly upregulated in melanomas (P=0.024), in which it correlated positively with the intensity of VEGF-A staining (P=0.041) and microvessel density (P=0.007).
  • In conclusion, S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth.
  • [MeSH-major] Biomarkers, Tumor / analysis. Capillaries / chemistry. Melanoma / blood supply. Melanoma / chemistry. Neovascularization, Pathologic / metabolism. S100 Proteins / analysis. Skin Neoplasms / blood supply. Skin Neoplasms / chemistry
  • [MeSH-minor] Aged. Antigens, CD / analysis. Female. Fibroblast Growth Factor 1 / analysis. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Prognosis. RNA, Messenger / analysis. Receptors, Cell Surface / analysis. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 20208480.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL035627; United States / NHLBI NIH HHS / HL / R01 HL035627; United States / NHLBI NIH HHS / HL / R01 HL035627-23
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / ENG protein, human; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / S100 Proteins; 0 / S100A13 protein, human; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 104781-85-3 / Fibroblast Growth Factor 1
  • [Other-IDs] NLM/ NIHMS204422; NLM/ PMC2882157
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3. Sidoroff A: [Epidemiology of cutaneous vascular neoplasms and malformations in childhood]. Handchir Mikrochir Plast Chir; 2009 Apr;41(2):65-9
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  • [Title] [Epidemiology of cutaneous vascular neoplasms and malformations in childhood].
  • PURPOSE: A representative compilation of data on the incidence and prevalence of benign cutaneous vascular neoplasms and malformations in childhood has been made.
  • Complex vascular malformations or severe cases of vascular tumours are very rare.
  • CONCLUSION: All in all, vascular lesions are very common findings in childhood, but in most cases harmless and transient in nature.
  • Complex and/or life-threatening severe vascular tumours and malformations that represent a considerable therapeutic challenge are extremely rare events.
  • [MeSH-major] Arteriovenous Malformations / epidemiology. Hemangioma / epidemiology. Skin / blood supply. Skin Neoplasms / epidemiology. Soft Tissue Neoplasms / epidemiology
  • [MeSH-minor] Age Factors. Austria. Child. Child, Preschool. Cohort Studies. Cross-Sectional Studies. Health Surveys. Hemangioma, Capillary / epidemiology. Hemangioma, Cavernous / epidemiology. Humans. Incidence. Infant. Infant, Newborn. Infant, Premature, Diseases / epidemiology. Neoplasm Regression, Spontaneous. Port-Wine Stain / epidemiology

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  • (PMID = 19180424.001).
  • [ISSN] 1439-3980
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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4. Brenn T, Fletcher CD: Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol; 2005 Aug;29(8):983-96
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  • [Title] Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.
  • Cutaneous angiosarcoma is a rare but well-recognized complication after radiation therapy.
  • Atypical post-radiation vascular lesions (AVLs) with a benign course have been described recently, but few cases with limited follow-up have been studied so far.
  • A total of 42 cases diagnosed as either radiation-associated cutaneous vascular lesions or angiosarcoma were retrieved from departmental and consultation files from 1995 to 2003.
  • The time interval from radiation was significantly shorter for the development of AVL (median, 3.5 years) compared with cutaneous angiosarcoma (median, 6 years).
  • These were fairly well-circumscribed lesions confined within superficial to mid dermis and composed of complex anastomosing and focally dilated vascular spaces.
  • This study outlines the morphologic spectrum of radiation-associated cutaneous AVLs.
  • No adverse outcome has been observed so far in this more benign subset of cases, but longer-term follow-up is necessary.
  • [MeSH-major] Hemangiosarcoma / etiology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin / blood supply. Skin / pathology. Skin Neoplasms / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / radiotherapy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16006792.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Leon-Villapalos J, Wolfe K, Calonje E, Kangesu L: Involuting solitary cutaneous infantile myofibroma and thrombocytopaenia: a previously unreported clinical association. J Plast Reconstr Aesthet Surg; 2007;60(11):1260-2
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  • [Title] Involuting solitary cutaneous infantile myofibroma and thrombocytopaenia: a previously unreported clinical association.
  • Behaviour is usually benign, but mortality has been described in lesions with visceral involvement.
  • We report a unique case of congenital solitary cutaneous infantile myofibroma in a neonate associated with self-limiting thrombocytopaenia.
  • It is important to distinguish accurately these lesions from benign vascular tumours like haemangiomas, locally aggressive vascular tumours like Kaposiform haemangioendotheliomas, which are often associated with Kasabach-Merritt phenomenon and also with malignant soft tissue tumours of infancy.
  • [MeSH-major] Diseases in Twins / diagnosis. Myofibroma / diagnosis. Skin Neoplasms / diagnosis. Thrombocytopenia / diagnosis
  • [MeSH-minor] Humans. Infant. Male. Neoplasm Regression, Spontaneous. Treatment Outcome

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  • (PMID = 17950191.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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6. Rader C, Piorkowski J, Bass DM, Babigian A: Epulis gravidarum manum: pyogenic granuloma of the hand occurring in pregnant women. J Hand Surg Am; 2008 Feb;33(2):263-5
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  • Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular tumor of the skin and mucous membranes.
  • We propose the term epulis gravidarum manum to describe this skin lesion.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Hand / pathology. Pregnancy Complications / pathology. Skin Diseases / pathology

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  • (PMID = 18294552.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • The whorls were often arranged around a central structure resembling an axon or a vascular structure.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • Its exact origin was unclear; it may have arisen from cutaneous nerves with deep extension or from neural structures in the sacral region.
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Weaver J, Billings SD: Postradiation cutaneous vascular tumors of the breast: a review. Semin Diagn Pathol; 2009 Aug;26(3):141-9
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  • [Title] Postradiation cutaneous vascular tumors of the breast: a review.
  • Postradiation vascular tumors fall into two categories:.
  • (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner.
  • Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists.
  • Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial.
  • Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20043513.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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9. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Several histologic variants of cutaneous FH have been described, some of which also have distinct clinical features including a propensity for local recurrence.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Other common findings included a hemangiopericytomalike vascular pattern (42%) and stromal hyalinization (39%).
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • In summary, deep FH has many histologic features in common with cutaneous cellular FH; however, it usually has a more diffusely storiform pattern than the latter, is well circumscribed, and may have striking hemangiopericytomalike vessels.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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10. Pisacane AM, Risio M: VEGF and VEGFR-2 immunohistochemistry in human melanocytic naevi and cutaneous melanomas. Melanoma Res; 2005 Feb;15(1):39-43
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  • [Title] VEGF and VEGFR-2 immunohistochemistry in human melanocytic naevi and cutaneous melanomas.
  • Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) play a key role in vasculogenesis and angiogenic sprouting, which are crucial for tumour development and metastasis.
  • In order to determine their possible role in the acquisition of metastatic potential throughout melanocytic tumour progression, VEGF and VEGFR-2 immunohistochemical expression were evaluated in 36 human melanocytic tumours of the skin (24 malignant melanomas and 12 common naevi).
  • Taken together, these data indicate that VEGF production is a common event in benign melanocytic tumours, whereas VEGFR-2 expression, co-localized in the cytoplasmic and nuclear membrane, is associated with progression towards invasive melanoma.
  • The role exerted by VEGF/VEGFR-2, however, seems to be independent of the development of a tumour-related capillary network.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism
  • [MeSH-minor] Cell Nucleus / metabolism. Cell Nucleus / pathology. Cytoplasm / metabolism. Cytoplasm / pathology. Humans. Immunoenzyme Techniques. Neoplasm Invasiveness

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  • (PMID = 15714119.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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11. Requena L, Luis Díaz J, Manzarbeitia F, Carrillo R, Fernández-Herrera J, Kutzner H: Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. J Cutan Pathol; 2008 Feb;35(2):225-30
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  • [Title] Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases.
  • The term hemangioendothelioma has been used in recent years to name a heterogeneous group of vascular neoplasms, intermediate in both biological behavior and histopathologic appearance between benign tumors (hemangiomas) and frankly malignant tumors (angiosarcomas).
  • The latter is a vascular neoplasm showing varying combinations of benign, low-grade malignant and malignant vascular components.
  • The neoplasm showed a more aggressive behavior than other reported cases of composite hemangioendothelioma and it developed satellitosis and metastases to the inguinal lymph nodes.
  • [MeSH-major] Foot Diseases / pathology. Hemangioendothelioma / pathology. Leg / pathology. Lymphatic Metastasis / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18190450.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein
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12. Urquhart JL, Uzieblo A, Kohler S: Detection of HHV-8 in pyogenic granuloma-like Kaposi sarcoma. Am J Dermatopathol; 2006 Aug;28(4):317-21
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  • Kaposi sarcoma (KS) is a low-grade vascular neoplasm associated with human herpesvirus-8 (HHV-8) infection.
  • Recently, we encountered 6 KS tumors that histologically mimicked pyogenic granuloma (PG), a common benign vascular tumor of the skin that usually does not figure in the histologic differential diagnosis of KS.

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  • (PMID = 16871034.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / latent nuclear antigen (LNA)
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13. Cohn ML, Goncharuk VN, Diwan AH, Zhang PS, Shen SS, Prieto VG: Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms. J Cutan Pathol; 2005 Sep;32(8):533-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms.
  • It is unknown whether claudins play a role in cutaneous melanoma.
  • Immunohistochemical studies were performed on tissue microarrays containing 19 benign melanocytic nevi (BN), 21 dysplastic nevi (DN), 23 primary malignant melanomas (MMs), and 31 metastatic melanomas (MMMs) using a polyclonal anti-claudin-1 antibody.
  • Immunoreactivity in tumor cells and associated vessels was graded by intensity and by percentage of reactive cells.
  • Tumor-associated vessels showed the following results: 11 of 19 (58%) in BN, 14 of 21 (67%) in DN, 17 of 23 (74%) in MM, and 6 of 31 (19%) in MMM.
  • A significant loss of expression was noted between MMM and all other lesions in tumor cells and associated vessels.
  • Within primary melanomas, there was a significant correlation between expression of claudin in tumor cells and Clark level/Breslow thickness.
  • Also significant was a decreased expression of claudin in tumor vessels of lesions with higher Breslow thickness or Clark level.
  • These data suggest that loss of claudin-1 may play a significant role in the acquisition of metastatic phenotype in cutaneous melanoma.
  • Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms.
  • [MeSH-major] Dysplastic Nevus Syndrome / metabolism. Melanoma / metabolism. Membrane Proteins / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Blood Vessels / metabolism. Blood Vessels / pathology. Claudin-1. Endothelium, Vascular / metabolism. Endothelium, Vascular / pathology. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Neoplasm Metastasis. Phenotype. Protein Array Analysis

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  • (PMID = 16115050.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins
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14. Trindade F, Haro R, Requena L: Giant angiolymphoid hyperplasia with eosinophilia on the chest. J Cutan Pathol; 2009 Apr;36(4):493-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiolymphoid hyperplasia with eosinophilia is a rare vascular proliferation characterized by single or multiple purplish, brownish papules and subcutaneous nodules, sometimes associated with pain or pruritus.
  • This rare benign process occurs with a female predominance.
  • Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp.
  • Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear.
  • The lesion is benign but may be persistent and is difficult to eradicate.
  • We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest.

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  • (PMID = 19278439.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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15. Pianezza ML, Singh D, Van der Kwast T, Jarvi K: Rare case of recurrent angiokeratoma of Fordyce on penile shaft. Urology; 2006 Oct;68(4):891.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiokeratomas are benign cutaneous vascular lesions characterized by dilated thin-walled blood vessels lying in the upper part of the dermis, mostly associated with an epidermal reaction such as acanthosis and/or hyperkeratosis.
  • [MeSH-major] Angiokeratoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Recurrence, Local. Penis

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  • (PMID = 17070385.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin.
  • To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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17. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma.
  • Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation.
  • We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
  • [MeSH-minor] Axilla. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymph Nodes / surgery. Male. Middle Aged. Mitotic Index. Neoplasm Metastasis / diagnosis. Treatment Outcome

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  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. Neurosurgery; 2006 Jul;59(1):E206; discussion E206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report.
  • OBJECTIVE: The majority of tumors of the cerebellopontine angle (CPA) are benign.
  • A neurological work-up revealed a large tumor in the left CPA radiographically diagnosed as a vestibular schwannoma.
  • INTERVENTION: A translabyrinthine approach revealed a pigmented, vascular neoplasm encasing vessels and cranial nerves of the left CPA.
  • The tumor was subtotally resected, and a histopathological diagnosis of melanoma was made.
  • The patient had no history of cutaneous melanoma and no other site of disease was ever discovered.

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  • (PMID = 16823290.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L: Myopericytoma: report of two cases associated with trauma. J Cutan Pathol; 2008 Sep;35(9):866-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern.
  • Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues.
  • The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies.
  • Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities.
  • [MeSH-major] Hemangiopericytoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Wounds and Injuries / complications
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Female. Humans. Male. Microfilament Proteins / metabolism. Middle Aged. Mouth Mucosa / injuries. Myosin Heavy Chains / metabolism. Nose / injuries. Treatment Outcome

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  • (PMID = 18494828.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; EC 3.6.4.1 / Myosin Heavy Chains
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20. Gouedard C, Dupré-Goetghebeur D, Gagneur A, Sannier K, Misery L: [Neonatal haemangiomatosis in identical twins with twin-twin transfusion syndrome]. Ann Dermatol Venereol; 2007 Nov;134(11):863-6
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  • INTRODUCTION: Benign natal haemangiomatosis is characterised by the presence of multiple congenital haemangiomas restricted to the skin.
  • It is differentiated from diffuse neonatal haemangiomatosis in which there is both cutaneous and visceral involvement, with higher morbidity and mortality.
  • It is a serious complication of twin pregnancies resulting from a dynamic process of interfoetal blood transfusion as a result of venous-venous or arteriovenous vascular anastomoses.
  • [MeSH-major] Diseases in Twins / congenital. Fetofetal Transfusion / genetics. Hemangioma / congenital. Infant, Premature. Infant, Premature, Diseases / genetics. Skin Neoplasms / congenital. Twins, Monozygotic
  • [MeSH-minor] Female. Fetal Growth Retardation / etiology. Humans. Infant, Newborn. Liver Neoplasms / congenital. Liver Neoplasms / genetics. Male. Neoplasm Regression, Spontaneous. Pregnancy

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  • (PMID = 18033069.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Edwards PC, Fantasia JE, Saini T, Rosenberg TJ, Sachs SA, Ruggiero S: Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Dec;102(6):765-72
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  • BACKGROUND: Neurofibromatosis 1 (NF1) is an autosomal dominantly inherited disorder caused by a spectrum of mutations affecting the Nf1 gene.
  • Affected patients develop benign and malignant tumors at an increased frequency.
  • Clinical findings include multiple cutaneous café-au-lait pigmentations, neurofibromas, axillary freckling, optic gliomas, benign iris hamartomas (Lisch nodules), scoliosis, and poorly defined soft tissue lesions of the skeleton.
  • Compared to normal bone, the Nf1-haploinsufficient bone in a patient with NF1 may be less able to remodel in response to as of yet unidentified stimuli (e.g. excessive mechanical stress and/or vascular fragility), and consequently may be more susceptible to developing CGCG-like lesions.
  • Alternatively, the CGCG in NF1 patients could represent a true neoplasm, resulting from additional, as of yet unidentified, genetic alterations to Nf1-haploinsufficient bone.

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  • (PMID = 17138179.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Schöniger S, Tivers MS, Baines SJ, Summers BA: Arteriovenous haemangioma in two dogs and a cat. J Comp Pathol; 2008 Aug-Oct;139(2-3):130-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Haemangiomas are benign vascular tumours and several types can be distinguished based on microscopical features.
  • One dog and the cat presented with a cutaneous vascular lesion, the other dog with a bleeding mass in the tongue.
  • Surgically excised masses comprised non-encapsulated proliferations of variably sized arterial- and venous-like vessels, accompanied by clusters of capillaries and immature vascular structures in the feline cutaneous tumour and the canine lingual neoplasm.
  • The results of this study expand the range of differential diagnoses for vascular neoplasms in the dog and cat.
  • [MeSH-major] Cat Diseases / pathology. Dog Diseases / pathology. Hemangioma / veterinary. Skin Neoplasms / veterinary. Tongue Neoplasms / veterinary

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  • (PMID = 18620702.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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