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Items 1 to 100 of about 483
1. Kaveri H, Punnya A: Pilomatricoma: a dermal analog of calcifying odontogenic cyst. Indian J Dent Res; 2008 Jul-Sep;19(3):261-3
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatricoma, also known as "Calcifying Epithelioma of Malherbe" is an uncommon, benign, cutaneous tumor originating from the hair matrix.
  • Most often, its precise preoperative diagnosis is not possible.
  • We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions.
  • [MeSH-major] Facial Neoplasms / diagnosis. Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans. Orbit / pathology

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  • (PMID = 18797106.001).
  • [ISSN] 0970-9290
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Krishna Swaroop DS, Ramakrishna BA, Bai SJ, Shanthi V: Trichoadenoma of Nikolowski. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):277-9
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  • Trichoadenoma of Nikolowski is a rare benign cutaneous tumor, which is usually solitary, nodular and occurs on the face or buttocks any time during adult life.
  • [MeSH-major] Neoplasms, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18603709.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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3. Varsori M, Dettwiler S, Chaloupka K: [Eyelid chondroid syringoma: a case report]. J Fr Ophtalmol; 2007 Jan;30(1):e3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Syringome chondroïde de la paupière: à propos d'un cas.
  • Chondroid syringoma is a rare benign skin tumor of the head and neck.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelid Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17287665.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J; 2010 Jan 6;29(1):131-44
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis.
  • [MeSH-major] Cell Cycle / physiology. Histone Deacetylases / metabolism. Tubulin / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Acetylation. Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Catalytic Domain. Cell Line, Tumor. Cytokinesis. Genes, Tumor Suppressor. Humans. Keratinocytes / cytology. Keratinocytes / drug effects. Keratinocytes / metabolism. Melanocytes / cytology. Melanocytes / drug effects. Melanocytes / metabolism. Melanoma / genetics. Melanoma / metabolism. Melanoma / pathology. Mice. Microtubules / metabolism. Mutation. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. Skin Neoplasms / genetics. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology


5. Daoudi A, Boutayeb F, Elmrini A: [Insulated arm pilomatrixoma: A rare localization. A case report]. Chir Main; 2006 Sep;25(3-4):163-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatrixoma also known as calcified epithelioma of Malherbe, is a rare benign cutaneous tumor.
  • [MeSH-major] Hair Diseases. Pilomatrixoma. Skin Neoplasms
  • [MeSH-minor] Adult. Arm. Female. Follow-Up Studies. Hair / pathology. Humans. Skin / pathology. Time Factors. Treatment Outcome

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  • (PMID = 17175805.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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6. Xia W, Longaker MT, Yang GP: P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts. Am J Physiol Regul Integr Comp Physiol; 2006 Mar;290(3):R501-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Keloids are abnormal fibrous growths of the dermis that develop only in response to wounding and represent a form of benign skin tumor.

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  • (PMID = 16467496.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / K08-GM-069977; United States / NIGMS NIH HHS / GM / R01-GM-65213
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TGFB2 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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7. Fernandes NF, Sinha S, Lambert WC, Schwartz RA: Cutaneous horn: a potentially malignant entity. Acta Dermatovenerol Alp Pannonica Adriat; 2009 Dec;18(4):189-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous horn: a potentially malignant entity.
  • A cutaneous horn is a conical, dense, hyperkeratotic protrusion that often appears similar to the horn of an animal.
  • It is a morphologic designation referring to an unusually cohesive keratinized material, not a true pathologic diagnosis.
  • Cutaneous horns occur in association with, or as a response to, a wide variety of underlying benign, pre-malignant, and malignant cutaneous diseases.
  • The most important common concern is distinguishing a hyperkeratotic actinic keratosis from a cutaneous squamous cell carcinoma.
  • Keratoacanthoma is another cause, as illustrated herein as a projective cutaneous tumor with a fingernail-like appearance.
  • The treatment of choice for cutaneous horns is shave excision with subsequent histopathologic evaluation to rule out underlying malignancy and to guide potential further therapy.
  • [MeSH-major] Keratosis / diagnosis
  • [MeSH-minor] Humans. Keratoacanthoma / diagnosis. Keratosis, Actinic / diagnosis

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  • (PMID = 20043059.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Letter; Review
  • [Publication-country] Slovenia
  • [Number-of-references] 30
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8. Sengul D, Sengul I, Astarci MH, Ustun H, Mocan G: Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34. Asian Pac J Cancer Prev; 2010;11(6):1615-9
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34.
  • BACKGROUND AND AIMS: Differential diagnosis of the group of benign trichoblastomas, trichofolliculomas, trichoadenomas and trichoepitheliomas, and basal cell carcinomas (BCCs) is troublesome for the clinician as well as the pathologist, especially when only small biopsy specimens are available.
  • METHODS: Thirty benign tumors of cutaneous appendages originating from hair follicles (BTCOHF) and 30 BCCs were retrieved from our archives and immunohistochemically stained.
  • CONCLUSIONS: CD34 may contribute to differential diagnosis of skin lesions.
  • [MeSH-major] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Skin Appendage / diagnosis. Hair Diseases / diagnosis. Hair Follicle / pathology. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Prognosis

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  • (PMID = 21338206.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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9. Hammami H, Benmously R, Badri T, Debbiche A, Ben Ayed M, Mokhtar I, Fenniche S: Atypical clinical appearance and localization of trichilemmoma. a case report. Pathologica; 2009 Jun;101(3):133-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichilemmoma is a benign cutaneous tumor that shows characteristics of differentiation similar to the outer hair sheath.
  • Several lines of evidence suggest that trichilemmoma should be considered in the differential diagnosis of any indistinct facial papule.
  • This report documents a non-facial example of trichilemmoma.
  • Atypical clinical appearance and localization of this neoplasm in our patient suggest that only histological findings are specific of this tumor.
  • [MeSH-major] Back / pathology. Hair Diseases / pathology. Skin Neoplasms / pathology

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  • (PMID = 19886550.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Tanaka Y, Bhunchet E, Shibata T: A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. Breast Cancer; 2008;15(2):175-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine spiradenoma (ES) is a fairly common, benign, cutaneous tumor originating from the sweat glands.
  • In contrast, the malignant counterpart of ES, malignant eccrine spiradenoma (MES), is extremely rare.
  • We present the first reported case of this tumor metastasizing to an intramammary lymph node (IMLN).
  • The uncommon metastasizing focus of the periumbilical MES and its histopathological similarity with a primary breast carcinoma made the diagnosis difficult.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18270794.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. González-Vela MC, Val-Bernal JF, Martino M, González-López MA, García-Alberdi E, Hermana S: Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma. Histol Histopathol; 2005 07;20(3):801-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements.
  • [MeSH-major] Fibroma / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 15944929.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin
  • [Number-of-references] 21
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12. Al-Daraji WI, Al-Dawoud A: Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association. Clin Exp Dermatol; 2005 Mar;30(2):137-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association.
  • A 75-year-old woman presented to her general practitioner with a keratotic skin lesion on her abdomen.
  • Primary cutaneous ganglioneuroma is an exceedingly rare benign tumour of the skin with only 13 cases having been reported in English literature.
  • We describe the second case of primary cutaneous ganglioneuroma associated with seborrheic keratosis.
  • [MeSH-major] Ganglioneuroma / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / complications

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  • (PMID = 15725239.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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13. Demirseren ME, Afandiyev K, Ceran C: Reconstruction of the perioral and perinasal defects with facial artery perforator flaps. J Plast Reconstr Aesthet Surg; 2009 Dec;62(12):1616-20
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twelve clinical cases with 14 perioral and perinasal skin defects resulting from malignant or benign skin tumour excision were reconstructed using facial artery perforator flaps.
  • The donor-site scars were designed parallel to the facial wrinkles when possible.
  • The aesthetically pleasing donor site based on the facial artery perforators offers a versatile tailor-made flap, because of the reliable presence of perforators, with a large arc of rotation.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Esthetics. Face / blood supply. Female. Humans. Male. Middle Aged. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Nose Neoplasms / pathology. Nose Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19010102.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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14. Naik V, Arsenovic N, Reed M: Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma. Dermatol Online J; 2009;15(9):6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous tumor characterized by proliferation of the eccrine gland elements closely associated with capillary angiomatosis and proliferation of other dermal elements, such as adipose tissue, hair and epidermis.
  • Clinically, this condition must be differentiated from other angiomatoses and a definitive diagnosis is based upon histology.
  • Eccrine angiomatous hamartoma is a benign slowly growing lesion for which aggressive treatment is not indicated.
  • [MeSH-major] Eccrine Glands / pathology. Hamartoma / diagnosis. Sweat Gland Diseases / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Friction. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Nevus, Blue / diagnosis. Skin / injuries. Skin Neoplasms / diagnosis

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  • (PMID = 19930993.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Kamarashev J, French LE, Dummer R, Kerl K: Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms. J Cutan Pathol; 2009 Oct;36(10):1099-102
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms.
  • Histologically, a well-circumscribed tumor of 3 mm diameter was found in the dermis.
  • Multinuclear cells were present as were numerous small-to-medium vessels throughout the tumor.
  • The tumor stroma showed myxoid areas.
  • The histological features and immunoprofile were consistent with the diagnosis of symplastic glomus tumor, a rare histological variant, which has been defined as a glomus tumor exhibiting marked nuclear atypia, in the absence of any other criteria for malignancy.
  • The biological behavior of the tumor is benign.
  • It is essential to differentiate this entity from malignant glomus tumor, which has metastatic potential.
  • Even prominent cellular atypia and nuclear pleomorphism in a glomus tumor as in our case is not a marker of malignancy in the absence of additional criteria.
  • [MeSH-major] Fingers / pathology. Glomus Tumor / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2009 John Wiley & Sons A/S.
  • (PMID = 19602065.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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16. Káram-Orantes M, Fonte-Avalos V, Zuloaga-Salcedo S, Domínguez-Cherit J: [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006]. Gac Med Mex; 2007 Sep-Oct;143(5):371-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006].
  • [Transliterated title] Frecuencia de tumores benignos durante el periodo de 2000-2006 en el Hospital General "Dr. Manuel Gea González".
  • BACKGROUND: Benign skin neoplasms are defined as autonomous growing tissue unrelated to normal growing of the skin, that persist even after the originating stimulus dissapears.
  • Almost all human beings have a certain number of benign cutaneous neoplasms and many never seek medical attention.
  • There is a dearth of information regarding the frequency of these tumors.
  • The aim of this study was to record the number of benign tumors studied at the Dermatology Department of a medical facility.
  • We included year of admission, number of biopsies, sex, age, tumor location, histological and clinical diagnoses.
  • RESULTS: We analyzed 9,436 biopsies of which 3,765 constituted benign neoplasms; 595 were not included and our total sample was 3,170 tumors.
  • The most frequent tumors according to histopathological diagnoses in descending order were: melanocytic, cutaneous cysts, fibrous tumors, vascular tumors, epidermal tumors, fat tumors, tumors with hair differentiation, neural tumors, glandular tumors, tumors with sebaceous differentiation, cartilage and bone tumors, and smooth muscle tumors.
  • The most common benign tumors were: Melanocytic nevi, epidermal cysts, seborrheic keratoses, pyogenic granulomas, lipomas and dermatofibromas.
  • CONCLUSIONS: Melanocytes represented by melanocytic nevi (junctional, intradermic and compound) were the most frequent benign neoplasms, followed by epidermoid cysts.
  • Our results illustrate the most common benign tumors observed in a dermatology department.
  • [MeSH-major] Neoplasms / epidemiology

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  • (PMID = 18246930.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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17. Choi CW, Park HS, Kim YK, Lee SH, Cho KH: Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. J Dermatol; 2008 Aug;35(8):499-502
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichoepithelioma (TE) is a benign neoplasm of the skin that resembles basal cell carcinoma (BCC) in its clinical and histological features.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Elastic Tissue / pathology. Keratin-15 / analysis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis. Staining and Labeling
  • [MeSH-minor] Biomarkers / analysis. Diagnosis, Differential. Histocytochemistry. Humans. Immunohistochemistry

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  • (PMID = 18789069.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Keratin-15
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18. Tran TA, Hayner-Buchan A, Jones DM, McRorie D, Carlson JA: Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). Am J Dermatopathol; 2007 Apr;29(2):197-200
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous balloon cell dermatofibroma (fibrous histiocytoma).
  • Dermatofibroma (DF) or cutaneous fibrous histiocytoma is a common benign skin tumor that exhibits multiple, distinct histologic variants.
  • Excisional biopsy revealed a circumscribed fibrous tumor populated by mostly clear and spindle cells.
  • A zonal arrangement separated the varied tumor cells where the most superficial, polypoid area showed large, clear polygonal balloon cells; the mid-dermal zone demonstrated a transition between balloon cells, epithelioid cells, and spindle cells; and the deep dermal zone had storiform arrangement of spindle cells, with the fascicles separated by coarse collagen bundles.
  • Ultrastructurally, the clear tumor cells were filled with multiple, empty, nonmembrane bound vacuoles of varying size.
  • DF with balloon cell change, likely secondary to persistent irritation, should be added to the differential diagnosis of cutaneous primary and metastatic neoplasms showing balloon cell degeneration such as balloon cell melanocytic nevi and renal cell carcinoma, respectively.
  • [MeSH-major] Heel. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Diagnosis, Differential. Factor XIIIa / analysis. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Neprilysin / analysis. Time Factors. Treatment Outcome. Vacuoles / ultrastructure

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  • (PMID = 17414448.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa; EC 3.4.24.11 / Neprilysin
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19. Badeloe S, Frank J: Clinical and molecular genetic aspects of hereditary multiple cutaneous leiomyomatosis. Eur J Dermatol; 2009 Nov-Dec;19(6):545-51

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  • [Title] Clinical and molecular genetic aspects of hereditary multiple cutaneous leiomyomatosis.
  • Multiple cutaneous and uterine leiomyomatosis syndrome (MCUL; OMIM 150800) is an autosomal dominantly inherited tumor predisposition disorder, characterized by leiomyomas of the skin and uterus.
  • Cutaneous leiomyoma can easily be recognized and confirmed by histological examination.
  • Recognition of these benign skin tumors can lead to the diagnosis of MCUL or HLRCC.
  • Timely diagnosis is crucial for offering affected individuals and families potentially life-saving regular prophylactic screening examinations for renal tumors.
  • Here we provide an overview of clinical and genetic features of this complex tumor syndrome and discuss patient management and current therapeutic strategies.
  • [MeSH-minor] Biomarkers / metabolism. Biopsy. Diagnosis, Differential. Female. Genetic Counseling. Genetic Predisposition to Disease. Humans. Kidney Neoplasms / genetics. Metabolism, Inborn Errors / genetics. Skin Neoplasms / genetics. Uterine Neoplasms / genetics

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  • (PMID = 19939761.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers; EC 4.2.1.2 / Fumarate Hydratase
  • [Number-of-references] 99
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20. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • In this paper case of 16-years-old male patient with many solid tumors in subcutaneous tissue on both arms will be reported.
  • The first skin lesion appeared on the left arm 6 years ago.
  • Histopathological test has proved the clinical diagnosis of pilomatrixoma.
  • [MeSH-major] Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Cicatrix / diagnosis. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Inflammation. Male. Treatment Outcome

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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21. Deutsch J, Trick D, Delank KW: [Giant scalp mass]. HNO; 2010 Dec;58(12):1204-7
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  • [Transliterated title] Monströser Tumor der Kopfhaut.
  • A 55-year-old man was referred to our department with bleeding from a painless tumor located at the left parietal region of the head which had been progressively growing for a period of 2 years.
  • The partly livid and ulcerated surface of the tumor was interspersed with light-yellow chalky material.
  • Histopathological examination led to the diagnosis of a giant pilomatricoma.
  • Pilomatricoma is a rare, benign skin neoplasm that originates from hair matrix cells and is most frequently located in the head and neck region.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
  • [Cites] J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):191-5 [9704827.001]
  • [Cites] Dermatol Surg. 2007 May;33(5):596-600 [17451583.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2000 Dec;126(12):1435-9 [11115277.001]
  • [Cites] Arch Dermatol. 1973 Oct;108(4):532-4 [4745286.001]
  • (PMID = 20577705.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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22. Chaplin A, Conrad DM, Tatlidil C, Jollimore J, Walsh N, Covert A, Pasternak S: Primary cutaneous PEComa. Am J Dermatopathol; 2010 May;32(3):310-2
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  • [Title] Primary cutaneous PEComa.
  • A 48-year-old woman attended a physician because of a solitary cutaneous nodule on the left lower leg.
  • Microscopic examination of the excisional specimen revealed a dermal tumor composed of nests of epithelioid cells exhibiting clear cytoplasm.
  • The tumor showed an infiltrative border.
  • Immunohistochemical evaluation revealed that the tumor cells were positive for HMB-45 and microftalmia associated transcription factor (MITF).
  • The tumor cells were negative for S-100 protein, alfa smooth muscle actin, HHF-35, and various cytokeratins.
  • The case is one of a primary cutaneous pecoma.
  • Pecomas are rare, recently described mesenchymal tumors composed of perivascular epithelioid cells.
  • They constitute a spectrum of lesions in different organs including angiomyolipoma of the kidney and liver, sugar tumor of the lung, lymphangiomatosis, and lymphangiomyoma.
  • Primary cutaneous PEComas are exceptionally rare and have only recently been recognized.
  • Follow-up data is limited but they appear to behave in a benign fashion.
  • We report an additional case with the goal of alerting dermatopathologists to this distinctive unusual neoplasm.
  • [MeSH-major] Perivascular Epithelioid Cell Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Biopsy. Desmin / analysis. Female. Humans. Leg. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Neoplasm Proteins / analysis. Treatment Outcome

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  • (PMID = 20139753.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / MITF protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Neoplasm Proteins
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23. Chwirot BW, Kuźbicki Ł: Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours. Melanoma Res; 2007 Jun;17(3):139-45
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  • [Title] Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours.
  • In this study, we investigated whether the COX-2 expression level might be a useful immunohistochemical marker for distinguishing cutaneous melanomas from benign melanocytic lesions.
  • Up to now, immunohistochemical markers have not ensured satisfactory sensitivity and specificity of differential pathologic diagnosis of melanoma.
  • In conclusion, COX-2 is the first immunohistochemical marker that allows the distinguishing of early melanomas from benign melanocytic lesions with both high sensitivity and specificity.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cyclooxygenase 2 / analysis. Immunohistochemistry. Melanoma / diagnosis. Membrane Proteins / analysis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Melanocytes / enzymology. Melanocytes / pathology. Neoplasm Staging. Predictive Value of Tests. ROC Curve. Sensitivity and Specificity

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  • (PMID = 17505259.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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24. Conscience I, Jovenin N, Coissard C, Lorenzato M, Durlach A, Grange F, Birembaut P, Clavel C, Bernard P: P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas. Eur J Dermatol; 2006 Sep-Oct;16(5):518-22
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  • [Title] P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas.
  • BACKGROUND: Recently, an increased expression of P16, a cell cycle regulatory tumor suppressor protein, has been demonstrated in cervical squamous neoplasms as a marker of malignancy.
  • In contrast, studies performed in skin carcinomas led to contradictory results.
  • OBJECTIVES: Our first aim was to evaluate P16 expression in different types of non-melanoma skin cancers compared with normal skin and benign tumors.
  • The second aim was to evaluate the relationship between P16 expression and the location of skin tumors (i.e. exposed versus non exposed sites).
  • Finally, we also studied Ki67 expression in skin carcinomas and control biopsies.
  • METHODS: Skin biopsy specimens with typical histologic features of squamous cell carcinoma (SCC; n = 30), Bowen's disease (BD; n = 17), basal cell carcinoma (BCC; n = 10), seborrheic keratosis (SK; n = 10) and normal human skin (NHS; n = 9) were obtained from 76 patients seen at our institution between 2001 and 2003.
  • RESULTS: P16 overexpression was observed in 58% of cutaneous carcinomas (SCC: 60%; BD: 58%; BCC: 50%) versus 0% of SK or NHS (0%) (p = 0.006).
  • Ki67 expression in over 5% of tumour cells was observed in 69% of cutaneous carcinomas (SCC: 54%; BD: 76%; BCC: 80%) versus 16% in the group including SK (30%) and NHS (0%) (p = 0.04).
  • Overexpression of P16 was associated with a high rate of Ki67 positive tumour cells in 23/57 malignant skin tumors (40%).
  • Sixty-eight percent of tumors located on sun-exposed areas versus 23% of those located on non sun-exposed areas overexpressed P16 (p = 0.02).
  • CONCLUSION: Our study demonstrated that the expression of P16 and Ki67 is associated with skin carcinomas.
  • Within cutaneous carcinoma specimens, P16 overexpression was significantly associated with the location on sun-exposed areas, suggesting a possible induction of P16 overexpression by UV radiation.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Skin Neoplasms / metabolism. Ultraviolet Rays

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  • (PMID = 17101472.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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25. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • CONCLUSIONS: The degree of Bcl-x expression in cutaneous adnexal glandular structures appears to be related to their mode of secretion, being strongest in cells with apoptotic degradation of the entire cell (sebocytes).
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • Bcl-x may be useful in identifying cells with sebaceous differentiation in poorly differentiated adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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26. Pagni F: [Cutaneous inflammatory pseudotumor (plasmocytoid granuloma)]. Pathologica; 2007 Jun;99(3):84-6
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  • [Title] [Cutaneous inflammatory pseudotumor (plasmocytoid granuloma)].
  • Cutaneous inflammatory pseudotumor is a rare benign condition that should be macroscopically differentiated, from dermatofibroma and metastases of carcinoma and, histologically from cutaneous lymphomas and other more aggressive diseases.
  • We report herein the case of a 63-year-old man with a painless nodule of the left arm skin with a rapid growth (1 month ago).
  • The final diagnosis was Plasmocytoid granuloma an entity that is recognized within the so called "Cutaneous inflammatory pseudotumor" together with the myofibroblastic tumor.
  • [MeSH-major] Arm. Granuloma, Plasma Cell / pathology. Skin Diseases / pathology

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  • (PMID = 17987729.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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27. Thomas L, Kluwe L, Chuzhanova N, Mautner V, Upadhyaya M: Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden. Neurogenetics; 2010 Oct;11(4):391-400
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  • [Title] Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.
  • Neurofibromatosis type 1, (NF1) is a complex, autosomal dominant disorder characterized by benign and malignant tumors which result from NF1 gene mutations.
  • We have analyzed the somatic mutations in 89 cutaneous neurofibromas derived from three unrelated NF1 patients with high tumor burden, by loss of heterozygosity (LOH) analysis of the NF1, TP53, RB1, and CDKN2A genes, by assessing microsatellite instability (MSI), by direct sequencing of the NF1, TP53, and several mismatch repair (MMR) genes and by multiplex ligation-dependent probe amplification of the NF1 and TP53 genes.
  • The aim was both to assess the possible clonality of these tumors and also to assess the involvement of other potential genetic loci in the development of these neurofibromas.
  • Each mutation was distinct demonstrating the independent origin of each tumor.
  • While somatic LOH of the TP53 gene was identified in four tumors, no specific deletions or sequence variations were identified.
  • LOH of markers flanking the RB1 gene was also found in one tumor but no CDKN2A mutations were detected.
  • Although evidence of MSI was seen in 21 tumors, no MMR gene alterations were identified.
  • The identification of LOH involving TP53 and RB1 loci is a novel finding in benign cutaneous neurofibromas possibly demonstrating an alternative underlying molecular mechanism associated with the development of these benign tumors from this cohort of patients.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Genes, Neurofibromatosis 1. Mutation. Neurofibroma / genetics. Skin Neoplasms / genetics

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  • (PMID = 20358387.001).
  • [ISSN] 1364-6753
  • [Journal-full-title] Neurogenetics
  • [ISO-abbreviation] Neurogenetics
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein
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28. Venkatesh K, Saini ML, Rangaswamy R, Murthy S: Neural fibrolipoma without macrodactyly: a subcutaneous rare benign tumor. J Cutan Pathol; 2009 May;36(5):594-6

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  • [Title] Neural fibrolipoma without macrodactyly: a subcutaneous rare benign tumor.
  • Neural fibrolipoma, also known as lipofibromatous hamartoma of nerves and neurolipomatosis, is a rare subcutaneous benign lesion involving the upper extremity with a marked predilection for median nerve.
  • Cut section revealed presence of fibrofatty tissue within and around the enlarged nerve.
  • Knowledge of characteristic histological and radiological findings is necessary for diagnosis and treatment.
  • [MeSH-minor] Adult. Fibroma / pathology. Fibroma / surgery. Fingers / pathology. Hand / pathology. Hand / surgery. Humans. Male. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 19476532.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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29. Clarke LE, Seykora JT: Primary cutaneous adenomyoepithelioma. J Cutan Pathol; 2007 Aug;34(8):654-7
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  • [Title] Primary cutaneous adenomyoepithelioma.
  • An 83-year-old Caucasian woman presented to her dermatologist with a 5-cm subcutaneous tumor on her right thigh.
  • Incisional biopsy showed a multinodular tumor composed of variably sized glands comprised of a luminal layer of epithelial cells surrounded by one or more layers of myoepithelial cells.
  • The histopathologic features resembled those of adenomyoepithelioma, an uncommon neoplasm usually encountered within the breast.
  • Primary cutaneous adenomyoepithelioma is very rare yet shares histopathologic features with common cutaneous lesions such as spiradenomas and benign mixed tumors (chondroid syringomas).
  • Primary cutaneous adenomyoepithelioma is part of the spectrum of epithelial-myoepithelial tumors that includes benign mixed tumor, myoepithelioma and myoepithelial carcinoma.
  • This rare tumor may mimic malignant lesions including metastatic adenocarcinoma.
  • Like its breast counterpart, primary cutaneous adenomyoepithelioma should probably be regarded as a neoplasm of borderline malignant potential.
  • [MeSH-major] Adenomyoma / pathology. Myoepithelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17640238.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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30. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
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  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • The most common site was the oral cavity (61.76 %).
  • The most frequently suspected clinical diagnosis was fibroma (17.65 %).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Makino E, Yamada J, Tada J, Arata J, Iwatsuki K: Cutaneous angiolipoleiomyoma. J Am Acad Dermatol; 2006 Jan;54(1):167-71
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  • [Title] Cutaneous angiolipoleiomyoma.
  • We describe a girl with cutaneous angiolipoleiomyoma on the buttock.
  • The 16-year-old girl had a 2.5- x 1.5-cm subcutaneous tumor on the right buttock, which was slightly tender.
  • The tumor appeared to be vascular and was, therefore, surgically excised.
  • Cutaneous angiomyolipoma, which is also known as cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor.
  • We point out the differences between the cutaneous and renal forms of angiomyolipoma, and conclude that the cutaneous lesion is distinct from a renal lesion in several aspects, including tuberous sclerosis complex association and immunoreactivity to both HMB-45 and MART-1.
  • [MeSH-major] Angiomyolipoma / diagnosis. Buttocks. Skin Neoplasms / diagnosis

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  • (PMID = 16384779.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Han JI, Kim DY, Na KJ: Dysregulation of the Wnt/beta-catenin signaling pathway in canine cutaneous melanotic tumor. Vet Pathol; 2010 Mar;47(2):285-91
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  • [Title] Dysregulation of the Wnt/beta-catenin signaling pathway in canine cutaneous melanotic tumor.
  • To investigate whether the Wnt/beta-catenin signal transduction pathway is involved in canine cutaneous melanomagenesis, 18 formalin-fixed paraffin-embedded canine cutaneous melanotic tumor tissues were examined.
  • For analysis of expression and translocation of beta-catenin in canine cutaneous melanotic tumors, semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were performed.
  • Semiquantitative RT-PCR showed a substantial increase in expression of ctnnb1 mRNA in canine cutaneous melanotic tumors compared to normal canine melanocytes, regardless of whether the tumor was benign or malignant.
  • Immunohistochemistry revealed cytoplasmic accumulation of beta-catenin in melanotic tumors.
  • The present study demonstrated that abnormal intracellular accumulation and substantially increased expression of beta-catenin are involved in canine cutaneous melanotic tumor.
  • [MeSH-major] Dog Diseases / pathology. Melanoma / veterinary. Skin Neoplasms / veterinary. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Dogs. Female. Gene Expression Regulation, Neoplastic. Immunohistochemistry / veterinary. Male. Molecular Sequence Data. RNA, Neoplasm / chemistry. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / veterinary. Sequence Alignment. Sequence Analysis, DNA. Signal Transduction. Statistics, Nonparametric

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  • (PMID = 20139375.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / Wnt Proteins; 0 / beta Catenin
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33. Mourmouras V, Fimiani M, Rubegni P, Epistolato MC, Malagnino V, Cardone C, Cosci E, Nisi MC, Miracco C: Evaluation of tumour-infiltrating CD4+CD25+FOXP3+ regulatory T cells in human cutaneous benign and atypical naevi, melanomas and melanoma metastases. Br J Dermatol; 2007 Sep;157(3):531-9
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  • [Title] Evaluation of tumour-infiltrating CD4+CD25+FOXP3+ regulatory T cells in human cutaneous benign and atypical naevi, melanomas and melanoma metastases.
  • They have not yet been investigated in the entire spectrum of melanocytic cutaneous lesions within a tumour site.
  • OBJECTIVES: To evaluate CD4+CD25+FOXP3+ Tregs among tumour-infiltrating lymphocytes in cutaneous melanocytic lesions.
  • METHODS: We analysed 128 lesions (10 benign junctional common naevi, 10 benign compound common naevi, 10 compound Spitz naevi, 10 junctional atypical naevi, 20 compound atypical naevi, 20 radial growth phase melanomas, 30 vertical growth phase melanomas and 18 melanoma metastases).
  • Their evaluation within a tumour site could be useful for prognostic and therapeutic purposes.
  • [MeSH-major] Lymphocytes, Tumor-Infiltrating / immunology. Melanoma / immunology. Nevus, Pigmented / immunology. Skin Neoplasms / immunology. T-Lymphocytes, Regulatory / immunology
  • [MeSH-minor] Antigens, CD4 / analysis. Biomarkers, Tumor / analysis. Female. Humans. Interleukin-2 Receptor alpha Subunit / metabolism. Male

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  • (PMID = 17596146.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / Biomarkers, Tumor; 0 / Interleukin-2 Receptor alpha Subunit
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34. Messeguer F, Sanmartín O, Martorell-Calatayud A, Nagore E, Requena C, Guillén-Barona C: [Acquired progressive lymphangioma (benign lymphangioendothelioma)]. Actas Dermosifiliogr; 2010 Nov;101(9):792-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acquired progressive lymphangioma (benign lymphangioendothelioma)].
  • [Transliterated title] Linfangioma progresivo adquirido (linfangioendotelioma benigno).
  • Acquired progressive lymphangioma is a rare vascular tumor with a locally aggressive behavior.
  • The tumor was in the hypogastric region and had arisen on a congenital vascular lesion previously diagnosed as multifocal cutaneous angiomatosis.
  • [MeSH-major] Lymphangioma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Angiomatosis / congenital. Angiomatosis / pathology. Disease Progression. Edema / etiology. Humans. Male. Movement Disorders / etiology. Pain / etiology. Skin Diseases / congenital. Skin Diseases / pathology

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  • (PMID = 21034710.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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35. Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS: Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi. Ophthalmology; 2007 Apr;114(4):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.
  • PURPOSE: To evaluate a kindred with familial uveal and cutaneous melanoma and to identify potential genetic and environmental factors that may predispose individuals to develop uveal melanoma.
  • METHODS: Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds.
  • MAIN OUTCOME MEASURES: Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma.
  • RESULTS: The proband and his mother had uveal melanoma, 3 cutaneous melanomas occurred among 2 siblings, and 2 other siblings had basal cell carcinomas.
  • No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF.
  • Seven out of 10 siblings had a history of cutaneous and/or ocular nevi.
  • Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma).
  • Six were also found to be in the "high-risk" classification for cutaneous malignancies based on scores from a previously validated risk assessment tool.
  • CONCLUSIONS: Our results strengthen the association between uveal melanoma, atypical nevi, and cutaneous melanoma.
  • This relationship supports the recommendation that individuals with a personal or family history of uveal melanoma, particularly in combination with atypical nevi, should be regularly screened for uveal and cutaneous melanoma.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Pedigree. Risk Factors. Sequence Analysis, DNA. Surveys and Questionnaires. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17207529.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p14ARF
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36. Gönül M, Gul U, Gunduz H, Artantas S, Demiriz M: Disseminated lobular capillary hemangioma: two case reports. J Dermatol; 2005 Dec;32(12):996-9
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  • Lobular capillary hemangioma, also known as pyogenic granuloma, is a common, solitary, benign neoplasm of the skin and mucous membranes.
  • We report two cases of disseminated lobular capillary hemangioma without an associated disorder.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Skin Diseases / pathology

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  • (PMID = 16471465.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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37. Benlier E, Alicioglu B, Kandulu H, Yurdakul ES, Top H: An unusual association of cutaneous myxoma with Favre-Racouchot syndrome. Prague Med Rep; 2008;109(4):321-4
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  • [Title] An unusual association of cutaneous myxoma with Favre-Racouchot syndrome.
  • We present a case of bilateral foot multiple cutaneous myxomas, associated with Favre-Racouchot syndrome (FRS) which is a dermatologic condition of multiple large comedones and nodules of the periorbital areas.
  • To our knowledge, there has been no report of the association of cutaneous myxoma and FRS.
  • Additionally, the magnetic resonance images of this benign tumor which is rare in the literature are presented.
  • [MeSH-major] Facial Dermatoses / complications. Foot Diseases / complications. Myxoma / complications. Skin Neoplasms / complications

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  • (PMID = 19537683.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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38. Vilallonga R, Espin Basany E, Armengol M: Cavernous hemangioma: unusual benign tumor of the transverse colon. Turk J Gastroenterol; 2009 Jun;20(2):146-9
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  • [Title] Cavernous hemangioma: unusual benign tumor of the transverse colon.
  • The rectosigmoid is the most common site of this disease in the gastrointestinal tract, while colonic localization is very uncommon.
  • This tumor can be diagnosed as solitary, multiple, or part of a more complex syndrome with cutaneous manifestations.
  • Sometimes, however, recognition of these tumors is difficult and can be a cause of failed surgical treatment and severe complications.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Hemangioma, Cavernous / diagnosis

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  • (PMID = 19530050.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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39. Venkataraman G, Hammadeh R: Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma. APMIS; 2006 Oct;114(10):744-8
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  • [Title] Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma.
  • Aneurysmal fibrous histiocytoma is an unusual variant of the spectrum of fibrous histiocytomas with the peculiar morphologic appearance of a benign aneurysmal vasoformative process that ultimately culminates in multiple microhemorrhages within the tumor.
  • It looks strikingly different from the usual cutaneous lesions encountered in clinical dermatology practice.
  • A single report of a cutaneous aneurysmal fibrous histiocytoma in the skin of the back of a 60-year-old male is described with emphasis on the immunostaining pattern and review of the literature.
  • There is a significant potential for confusion of this lesion with other cutaneous lesions, clinically as well as pathologically.
  • Caution is warranted to avoid misinterpretation of cutaneous fibrohistiocytic tumors.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aneurysm / pathology. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17004978.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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40. Jokinen CH, Wolgamot GM, Argenyi ZB: Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin. J Cutan Pathol; 2008 Feb;35(2):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin.
  • Schwannoma and neurofibroma account for the majority of cutaneous benign peripheral nerve sheath tumors and usually pose little diagnostic difficulty in their classic forms.
  • In rare instances, however, benign peripheral nerve sheath tumors may display epithelioid morphology and lack otherwise usual features of schwannoma or neurofibroma, making classification difficult.
  • These unusual changes may prompt consideration of other benign neoplasms or a malignancy.
  • Benign epithelioid peripheral nerve sheath tumor (BEPNST) is a somewhat non-specific term recently proposed to describe these neoplasms of imprecise histogenesis.
  • We report a unique case of cutaneous BEPNST with a peculiar arrangement of abundant extracellular collagen, different than the previously observed patterns.
  • Specifically, the neoplastic cells in this tumor were nearly obscured by the collagen, which formed large nodules and compressed the majority of the few remaining tumor cells to the periphery of the lesion.
  • This excessive collagen production emphasizes the importance of adequate sampling to ensure a correct diagnosis.
  • [MeSH-major] Collagen / ultrastructure. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Neck / pathology

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  • (PMID = 18190449.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9007-34-5 / Collagen
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41. Abalo-Lojo JM, Cameselle-Teijeiro J, Gonzalez F: Pilomatrixoma: late onset in two periocular cases. Ophthal Plast Reconstr Surg; 2008 Jan-Feb;24(1):60-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • First described by Malherbe and Chenantais in 1880, pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • It is typically a tumor of younger individuals and rarely presents in older patients.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18209650.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Soldano AC, Meehan SA: Cutaneous solitary fibrous tumor: a report of 2 cases and review of the literature. Am J Dermatopathol; 2008 Feb;30(1):54-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous solitary fibrous tumor: a report of 2 cases and review of the literature.
  • Solitary fibrous tumor is an uncommon mesenchymal neoplasm that can arise in both pleural and extrapleural locations.
  • Composed of spindled cells intimately admixed with collagen bundles arranged in a "patternless pattern," this heterogeneous tumor can mimic a variety of benign and malignant mesenchymal neoplasms.
  • We present the histological and immunohistochemical findings of two primary cutaneous solitary fibrous tumors, discuss the differential diagnosis, and review the literature.
  • Although solitary fibrous tumors in cutaneous and subcutaneous regions are extremely rare, it should be considered in the differential diagnosis of primary spindle cell neoplasms of the skin.
  • [MeSH-major] Skin Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18212546.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Cohen PR, Martinelli PT, Schulze KE, Nelson BR: The cuticular purse string suture: a modified purse string suture for the partial closure of round postoperative wounds. Int J Dermatol; 2007 Jul;46(7):746-53
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  • BACKGROUND: The purse string suture can be used to provide primary closure for small skin defects or as a partial closure for larger round wounds.
  • The size of the defect is reduced secondary to the tension placed on the suture, which uniformly advances the skin from the entire periphery of the wound.
  • The location and types of the tumors removed were also summarized.
  • RESULTS: Postoperative wounds were created following Mohs' micrographic excision of nonmelanoma skin cancer (basal cell carcinoma, 44; squamous cell carcinoma, 25), wide local excision of melanoma (29), or conservative excision of benign cutaneous neoplasms (two).
  • The incidence of purse string suture for partial closure of each tumor was 4.1% for basal cell carcinoma, 7.3% for squamous cell carcinoma, and 46.3% for melanoma.
  • The tumors were equally distributed on the trunk, head and neck, and extremities; however, purse string closures for basal cell carcinomas were more frequent on the trunk, head, and neck, relative to squamous cell carcinomas and melanomas, which were more common on the extremities.
  • CONCLUSION: The cuticular purse string suture is a rapid and simple procedure that provides complete or partial closure of round skin defects and excellent long-term cosmetic and functional results.
  • The purse string suture is also useful following nonmelanoma skin cancer removal in patients who insist on maintaining an active lifestyle in the immediate postoperative period, who are receiving one or more systemic anticoagulant and/or antiplatelet agents, and who have large surgical wounds that would require either a skin graft or a local cutaneous flap in order to close the postoperative defect.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Melanoma / surgery. Skin Neoplasms / surgery. Suture Techniques

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  • (PMID = 17614809.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. El Ibrahimi A, Daoudi A, Znati K, Elmrini A, Boutayeb F: [Insulated leg pilomatrixoma: a rare localization]. Ann Chir Plast Esthet; 2009 Aug;54(4):388-91
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  • [Transliterated title] Pilomatricome isolé de la jambe. Une rare localisation.
  • Pilomatrixoma is a benign skin neoplasm of the hair follicle.
  • It's usually misdiagnosed and confused with other skin lesions.
  • [MeSH-major] Hair Diseases. Leg. Pilomatrixoma. Skin Neoplasms

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  • (PMID = 19195758.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Lin YC, Hsiao PF, Wu YH, Sun FJ, Scher RK: Recurrent digital glomus tumor: analysis of 75 cases. Dermatol Surg; 2010 Sep;36(9):1396-400

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent digital glomus tumor: analysis of 75 cases.
  • BACKGROUND: Glomus tumors are rare, benign, cutaneous neoplasms that must be excised completely to prevent recurrence.
  • OBJECTIVE: To investigate factors associated with recurrence of glomus tumors after surgery.
  • METHODS AND MATERIALS: Fifty-eight women and 17 men with digital glomus tumors underwent surgery between 1990 and 2008 at our hospital.
  • RESULTS Mean age at diagnosis was 41.8, with an average diagnostic delay of 3.9 years.
  • The tumor was located on a finger in 70 cases (right, 29; left, 41) and a toe in five (right, 3; left, 2).
  • The tumor recurred in 13 (17%) patients.
  • Recurrence was more likely if the tumor was skin-colored (odds ratio (OR)=31.67, 95% confidence interval (CI)=2.68-373.74, p=.006) or located within the nail matrix (OR=5.79, 95% CI=1.03-32.49, p=.046).
  • CONCLUSION: Skin-colored tumors or those in the nail matrix are at higher risk of recurrence.
  • [MeSH-major] Fingers. Glomus Tumor / epidemiology. Glomus Tumor / surgery. Neoplasm Recurrence, Local / epidemiology

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  • [Copyright] © 2010 by the American Society for Dermatologic Surgery, Inc.
  • (PMID = 20629689.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Fernandez-Flores A: Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53. Rom J Morphol Embryol; 2010;51(2):295-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53.
  • BACKGROUND: Cutaneous smooth muscle tumors are rare and sometimes the differential diagnosis between leiomyoma and leiomyo-sarcoma is difficult and based in very subtle criteria.
  • This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas.
  • MATERIAL AND METHODS: We studied 30 benign cutaneous smooth muscle tumors, including angioleiomyomas, common leiomyomas and a symplastic leiomyoma, as well as four leiomyosarcomas and one cutaneous metastasis of leiomyosarcoma.
  • All cases were reviewed in order to confirm the diagnosis, before the cases were included in the study.
  • RESULTS: Six cases from the 31 (19.35%) benign cutaneous smooth muscle tumors showed some expression of p53.
  • The case of a cutaneous metastasis of leiomyosarcoma showed expression of p53 by 20% of cells.
  • CONCLUSIONS: We conclude that expression of p53 by a high percentage of cells in a cutaneous smooth muscle cell tumor should be considered as highly suspicious for malignancy.
  • [MeSH-major] Leiomyoma / metabolism. Leiomyosarcoma / metabolism. Skin Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20495746.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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48. Walsh SN, Sangüeza OP: PEComas: a review with emphasis on cutaneous lesions. Semin Diagn Pathol; 2009 Aug;26(3):123-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PEComas: a review with emphasis on cutaneous lesions.
  • The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC).
  • PEC tumors (or PEComas), other than AML, CCST, and LAM, are not associated with TSC and typically occur in middle-aged adult females.
  • These neoplasms are composed of nests and fascicles of clear to granular epithelioid and/or spindled cells with a consistent arrangement around blood vessels.
  • Although the most common sites are the gastrointestinal and genitourinary tracts, approximately 23 cases, to date, of PEComas arising in the skin have been reported.
  • Primary cutaneous PEComas also have a predilection for adult females and most often present as a painless mass on the extremities.
  • In contrast to other sites, the myogenic marker most commonly expressed in PEComas of the skin is desmin.
  • Most reported cutaneous PEComas follow a benign course, however, a malignant case has been reported.
  • [MeSH-major] Desmin / metabolism. Epithelioid Cells / pathology. Perivascular Epithelioid Cell Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Female. Humans. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 20043511.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
  • [Number-of-references] 65
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49. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9

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  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • All eight cases of AMT of the skin showed CK15 immunostaining of the neoplastic cells, and all four cases of syringocystadenoma papilliferum, all five cases of spiradenoma, and both cases of cylindroma also showed a focally positive reaction to CK15.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • In AMT of the skin, the proportion of CK15-positive cells in the follicular or sebaceous differentiation group (78.8%, average of four cases) was significantly higher than the group without this differentiation (8.8%, average of four cases).
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • AMT of the skin with follicular or sebaceous differentiation are considered to show an immature stage of apocrine differentiation still rich in stem cells or to originate from stem cells with an incompletely established apocrine fate.
  • The partially positive reaction for CK15 in syringocystadenomas papilliferum and spiradenoma/cylindroma may depend on the ability to express CK15 in stem cells with an apocrine fate or result from the follicular and apocrine nature of this neoplasm.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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50. Vonderheid EC: On the diagnosis of erythrodermic cutaneous T-cell lymphoma. J Cutan Pathol; 2006 Feb;33 Suppl 1:27-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] On the diagnosis of erythrodermic cutaneous T-cell lymphoma.
  • Erythrodermic cutaneous T-cell lymphoma (E-CTCL) is the cause of less than 5% of all cases of generalized erythroderma.
  • A methodical evaluation of skin, blood, and lymph node samples using standard histology, immunohistochemistry (IHC), flow cytometry (FC), and molecular analysis for evidence of a dominant T-cell clone has been recommended in a recently published diagnostic algorithm.
  • In this commentary, the author discusses available information regarding the role of these diagnostic methods for the diagnosis of E-CTCL with emphasis on personal observations regarding skin IHC and polymerase chain reaction (PCR)-based molecular studies as adjunct diagnostic studies on a series of 55 patients with erythrodermic mycosis fungoides and 50 patients with Sézary syndrome compared to 50 patients with extensive benign inflammatory skin disease.
  • The conclusions are (1) IHC of the skin does not reliably differentiate E-CTCL from benign simulants, (2) presence of phenotypically abnormal T cells in the blood or expanded subsets of CD4+CD7- or CD4+CD26- cells by FC is particularly helpful as a diagnostic study, (3) the presence of an identical T-cell clone in the skin and blood also is a specific diagnostic criterion for E-CTCL, but exceptions may occur, and (4) the PCRgamma-denaturing gradient gel electrophoresis technique appears to be more reliable than PCRgamma-single-stranded conformational polymorphism for diagnostic purposes.
  • [MeSH-major] Dermatitis, Exfoliative / diagnosis. Lymphoma, T-Cell, Cutaneous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Polymerase Chain Reaction

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  • (PMID = 16412210.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 107
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51. Fernandez NJ, West KH, Jackson ML, Kidney BA: Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors. Vet Pathol; 2005 Jul;42(4):437-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
  • Immunohistochemical and histochemical stains are useful adjunct techniques in the diagnosis of canine cutaneous round cell tumors, which can appear histologically similar.
  • We applied a panel of monoclonal antibodies (recognizing tryptase, chymase, serotonin for mast cells; CD1a, CD18, MHC class II for histiocytes; CD3 for T lymphocytes; CD79a for B lymphocytes and plasma cells) and one histochemical stain (naphthol AS-D chloroacetate for chymase activity) to formalin-fixed, paraffin-embedded sections of canine cutaneous mast cell tumors, histiocytomas, lymphosarcomas, plasmacytomas, and unidentified round cell tumors.
  • Of 21 tumors with a histologic diagnosis of mast cell tumor, 7/7 (100%) grade I, 6/7 (85.7%) grade II, and 3/7 (42.9%) grade III tumors were diagnosed as mast cell tumors based on positive staining for tryptase antigen and chymase activity.
  • Chymase was detected immunohistochemically in both tumor and nontumor cells, while serotonin was not detected in most mast cell tumors, and thus, neither was useful in the diagnosis of mast cell tumors.
  • A final diagnosis was obtained for 4/5 (80%) of the unidentified tumors, indicating the usefulness of multiple stains in poorly differentiated round cell tumors.
  • [MeSH-major] Dog Diseases / pathology. Histiocytoma, Benign Fibrous / veterinary. Immunohistochemistry / veterinary. Lymphoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Antibodies, Monoclonal. Antigens, CD18. Chymases. Coloring Agents. Diagnosis, Differential. Dogs. Histological Techniques / veterinary. Serine Endopeptidases. Tryptases

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  • (PMID = 16006603.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD18; 0 / Coloring Agents; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.39 / Chymases; EC 3.4.21.59 / Tryptases
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52. Sengul D, Sengul I, Astarci MH, Ustun H, Mocan G: CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle. Pol J Pathol; 2010;61(3):140-6
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  • [Title] CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.
  • AIMS: Differential diagnosis between the group of trichoadenoma, trichofolliculoma, trichoepithelioma, trichoblastoma and basal cell carcinoma has been creating some difficulties for the pathologist and the clinicians, particularly in the presence of small specimens.
  • MATERIAL AND METHODS: A total of 30 cases of benign tumours of cutaneous appendages originating from the hair follicle and 30 cases of basal cell carcinoma were retrieved from the archives deposited from 2004 to 2008.
  • The stromal CD10 immunopositivity of benign tumours of cutaneous appendages originating from the hair follicle was stronger than the other (p = 0.003) regarding both the numerical and the degree of expression.
  • CONCLUSIONS: CD10 may be very useful for the differential diagnosis between them particularly in the small and superficial biopsies and it may be even a life-saving method in some selected cases.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Hair Follicle / pathology. Neprilysin / metabolism. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 21225496.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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53. Sherrod QJ, Chiu MW, Gutierrez M: Multiple pilomatricomas: cutaneous marker for myotonic dystrophy. Dermatol Online J; 2008;14(7):22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple pilomatricomas: cutaneous marker for myotonic dystrophy.
  • Pilomatricoma (calcifying epithelioma of Malherbe) is a benign tumor of hair matrix derivation.
  • Since the onset of MPs may precede the signs of myotonic dystrophy, they can serve as potential early cutaneous markers for this systemic disease.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Myotonic Dystrophy / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18718206.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Several histologic variants of cutaneous FH have been described, some of which also have distinct clinical features including a propensity for local recurrence.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Only a single small series of these neoplasms has been published, and their clinical behavior is not well characterized.
  • The tumors ranged from 0.5 to 25 cm in size (median, 3.0 cm) and were well circumscribed grossly and microscopically.
  • All tumors were composed of bland ovoid to spindle cells arranged in a storiform pattern with admixed lymphocytes.
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • In summary, deep FH has many histologic features in common with cutaneous cellular FH; however, it usually has a more diffusely storiform pattern than the latter, is well circumscribed, and may have striking hemangiopericytomalike vessels.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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55. Gambichler T, Kreuter A, Grothe S, Altmeyer P, Brockmeyer NH, Rotterdam S: Versican overexpression in cutaneous malignant melanoma. Eur J Med Res; 2008 Nov 24;13(11):500-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Versican overexpression in cutaneous malignant melanoma.
  • OBJECTIVE: Tumor growth regulation by extracellular matrix components has been one of the main topics on tumor biology in the last years.
  • PATIENTS AND METHODS: Paraffin-embedded sections of benign nevi (BN), dysplastic nevi (DN), and primary SSM were assessed.
  • Decorin as well versican expression of SSM did not significantly correlate with Breslow tumor thickness or Clark level.
  • [MeSH-major] Melanoma / metabolism. Melanoma / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Versicans / metabolism

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  • (PMID = 19073385.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans; 0 / VCAN protein, human; 126968-45-4 / Versicans
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56. Einspahr JG, Thomas TL, Saboda K, Nickolof BJ, Warneke J, Curiel-Lewandrowski C, Ranger-Moore J, Duckett L, Bangert J, Fruehauf JP, Alberts DS: Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. Cancer; 2007 Dec 1;110(11):2519-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression.
  • BACKGROUND: A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN).
  • Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers.
  • METHODS: Markers of angiogenesis that included expression of the vascular endothelial growth factor A (VEGF-A) and microvessel density counts (MVD) were evaluated in 13 prospectively collected benign nevi (BN) and 19 DN from 16 individuals and in a comparison group of 17 primary melanomas (16 archival samples and 1 prospective melanoma).
  • [MeSH-major] Melanoma / metabolism. Skin Neoplasms / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Disease Progression. Dysplastic Nevus Syndrome / metabolism. Female. Humans. Immunohistochemistry. Male. Microcirculation. Middle Aged. Neovascularization, Pathologic. Nevus / metabolism. Prospective Studies

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17932890.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / CA27502
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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57. Haider AS, Peters SB, Kaporis H, Cardinale I, Fei J, Ott J, Blumenberg M, Bowcock AM, Krueger JG, Carucci JA: Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol; 2006 Apr;126(4):869-81
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  • [Title] Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia.
  • Using high-density oligonucleotide arrays, we measured expression of >12,000 genes in surgical excisions of invasive human squamous cell carcinomas (SCCs) versus site-matched control skin.
  • As SCCs are composed of epithelial cells, which are both hyperplastic and invasive, we sought to define gene sets associated with these biologic processes by comparing gene expression to psoriasis vulgaris, which is a condition of benign keratinocyte hyperplasia without invasiveness or pre-malignant potential.
  • We found that benign hyperplasia is associated with upregulation of genes including DEFB4 (defensin B4), SERPINB3 (serine proteinase inhibitor, member 3), STAT1 (signal transducer and activator of transcription 1), K16 (keratin 16), CEACAMs (carcinoembryonic antigen-related cell adhesion molecules), and WNT 5A (wingless-type MMTV integration site family, member 5A).
  • Growth factor pleiotrophin (PTN) was expressed at higher levels in non-tumor-bearing skin adjacent to excised SCC.
  • The current study defines a unique gene expression signature for cutaneous SCC in humans and suggests potential roles for WNT, FZD, and PTN in the pathogenesis of SCC.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Gene Expression Regulation, Neoplastic. Genes, Neoplasm. Skin Neoplasms / diagnosis
  • [MeSH-minor] Cell Proliferation. Diagnosis, Differential. Genomics. Humans. Hyperplasia / diagnosis. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16470182.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / A149832; United States / NCRR NIH HHS / RR / M01-RR00102; United States / PHS HHS / / R01-A149572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Temam F, Bizuneh E, Leekassa R: Disseminated form of syringoma (eruptive syringoma) sparing the face-a rare presentation causing diagnostic challenge. Ethiop Med J; 2008 Jul;46(3):273-6
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  • Syringomas are benign neoplasms of the skin commonly appearing around the eye lids.
  • The lesions are asymptomatic, firm, discrete, translucent or skin colored flat-topped papules.
  • [MeSH-major] Sweat Gland Neoplasms / pathology. Syringoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19271392.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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59. Edinger JT, Kant JA, Swerdlow SH: Cutaneous marginal zone lymphomas have distinctive features and include 2 subsets. Am J Surg Pathol; 2010 Dec;34(12):1830-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous marginal zone lymphomas have distinctive features and include 2 subsets.
  • Cutaneous marginal zone lymphomas (CMZL) were segregated in the WHO/EORTC consensus classification but grouped with other MALT lymphomas in the subsequent WHO classification.
  • The IgM cases showed a predominance of B cells in 5 out of 6 (P=0.0003), a diffuse proliferation of CD20 B cells in all (P<0.0001), CXCR3+ B cells in 2 out of 5 (P<0.04), and extracutaneous disease in 3 out of 6 (P<0.008).
  • These findings support the presence of 2 types of cutaneous MALT lymphomas with the class-switched cases being the most distinctive but still sharing significant features with MALT lymphomas from other sites, specifically an extranodal extramedullary CD5-, CD10- indolent small B cell lymphoma with plasmacytic differentiation, frequent benign follicular structures, and not fulfilling the criteria for any other well-defined lymphoma.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Humans. Immunoglobulin Class Switching. Immunoglobulins / genetics. Immunoglobulins / metabolism. Male. Middle Aged. Phenotype. Receptors, CXCR3 / metabolism

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  • (PMID = 21107089.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCR3 protein, human; 0 / Immunoglobulins; 0 / Receptors, CXCR3
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60. Logié A, Dunois-Lardé C, Rosty C, Levrel O, Blanche M, Ribeiro A, Gasc JM, Jorcano J, Werner S, Sastre-Garau X, Thiery JP, Radvanyi F: Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet; 2005 May 1;14(9):1153-60
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  • [Title] Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans.
  • Although acanthosis nigricans, a benign skin tumor, has been found in some syndromes associated with germinal activating mutations of FGFR3, the role of activated FGFR3 in the epidermis has never been investigated.
  • Mice expressing the transgene developed benign epidermal tumors with no sign of malignancy.
  • These skin lesions had features in common with acanthosis nigricans and other benign human skin tumors, including seborrheic keratosis, one of the most common benign epidermal tumors in humans.
  • A large proportion of these tumors (39%) harbored somatic activating FGFR3 mutations, identical to those associated with skeletal dysplasia syndromes and bladder and cervical neoplasms.
  • Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans.
  • [MeSH-major] Gene Expression. Keratosis, Seborrheic / genetics. Point Mutation. Protein-Tyrosine Kinases / genetics. Receptors, Fibroblast Growth Factor / genetics. Skin Neoplasms / genetics

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  • (PMID = 15772091.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Fgfr3 protein, mouse; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; G34N38R2N1 / Bromodeoxyuridine
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61. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • Its exact origin was unclear; it may have arisen from cutaneous nerves with deep extension or from neural structures in the sacral region.
  • [MeSH-major] Anus Neoplasms / veterinary. Horse Diseases / pathology. Nerve Sheath Neoplasms / veterinary
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Deng A, Petrali J, Jaffe D, Sina B, Gaspari A: Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol; 2005 Oct;27(5):432-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign cutaneous pseudoglandular schwannoma: a case report.
  • Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion.
  • We report here a patient with a benign cutaneous schwannoma composed of predominantly gland-like spaces that contained mucinous material and were lined by Schwann cells confirmed by immunohistochemistry and ultrastructural studies.
  • The tumor was well circumscribed and showed minimal cytologic atypia, indicating benignity.
  • We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphologic diversity of schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16148415.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Silva MS, Weiss M, Brum MC, Dos Anjos BL, Torres FD, Weiblen R, Flores EF: Molecular identification of bovine papillomaviruses associated with cutaneous warts in southern Brazil. J Vet Diagn Invest; 2010 Jul;22(4):603-6

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  • [Title] Molecular identification of bovine papillomaviruses associated with cutaneous warts in southern Brazil.
  • Bovine papillomaviruses (BPVs) are widespread pathogens mainly associated with benign, self-limiting, cutaneous lesions (warts).
  • Warts of 2 cattle harbored L1 sequences of a new BPV type (BAA5), otherwise identified almost exclusively in healthy skin.
  • The newly proposed BPV type "BR-UEL-4" was identified in a sarcoid tumor of a horse.

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  • (PMID = 20622233.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Talantov D, Mazumder A, Yu JX, Briggs T, Jiang Y, Backus J, Atkins D, Wang Y: Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res; 2005 Oct 15;11(20):7234-42
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  • [Title] Novel genes associated with malignant melanoma but not benign melanocytic lesions.
  • PURPOSE: Cutaneous melanoma is a common, aggressive cancer with increasing incidence.
  • EXPERIMENTAL DESIGN: Total RNA isolated from 45 primary melanoma, 18 benign skin nevi, and 7 normal skin tissue specimens were analyzed on an Affymetrix Hu133A microarray containing 22,000 probe sets.
  • RESULTS: Hierarchical clustering revealed a distinct separation of the melanoma samples from the benign and normal specimens.
  • Differential gene expression of two melanoma-specific genes, PLAB and L1CAM, were tested by a one-step quantitative reverse transcription-PCR assay on primary malignant melanoma, benign nevi, and normal skin samples, as well as on malignant melanoma lymph node metastasis and melanoma-free lymph nodes.
  • CONCLUSION: Our study systematically identified novel melanoma-specific genes and showed the feasibility of using a combination of PLAB and L1CAM in a reverse transcription-PCR assay to differentiate clinically relevant samples containing benign or malignant melanocytes.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / genetics. Melanocytes / metabolism. Melanoma / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Cluster Analysis. Female. Gene Expression Profiling. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16243793.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Weiss T, Weber L, Scharffetter-Kochanek K, Weiss JM: Solitary cutaneous dendritic cell tumor in a child: role of dendritic cell markers for the diagnosis of skin Langerhans cell histiocytosis. J Am Acad Dermatol; 2005 Nov;53(5):838-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary cutaneous dendritic cell tumor in a child: role of dendritic cell markers for the diagnosis of skin Langerhans cell histiocytosis.
  • We describe a child with a solitary dendritic cell (DC) tumor positive for S-100 protein, CD1a, and HLA-DR with the clinical and histopathologic features of a so-called solitary variant of congenital self-healing Hashimoto-Pritzker reticulohistiocytosis (CSHRH).
  • CSHRH is a spontaneously regressing, benign form of Langerhans cell histiocytosis (LCH) and was thought to be a histiocytosis consisting of precursor Langerhans cells.
  • In our study the tumor cells did not express CD68, indicating that they represent mature DCs.
  • Because of the negative finding for Langerin, it cannot be assessed whether the tumor consists of terminally mature Langerhans cells that have lost Langerin expression upon maturation or of mature dermal DCs.
  • Therefore the literature on CSHRH is reviewed in light of present knowledge on cutaneous DC immunology.
  • [MeSH-major] Dendritic Cells. Histiocytosis, Langerhans-Cell / pathology. Skin Diseases / pathology. Skin Neoplasms / pathology


66. Tucker T, Wolkenstein P, Revuz J, Zeller J, Friedman JM: Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology; 2005 Jul 26;65(2):205-11

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  • [Title] Association between benign and malignant peripheral nerve sheath tumors in NF1.
  • OBJECTIVE: People with neurofibromatosis type 1 (NF1) have a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST).
  • However, it is not known whether an individual's risk of developing an MPNST is associated with the burden of benign neurofibromas.
  • The authors conducted a study to determine whether people with NF1 who have benign neurofibromas of various kinds are at greater risk of developing MPNSTs than patients with NF1 who lack these benign tumors.
  • METHODS: Clinical information on 476 NF1 probands in the Henri Mondor Database was analyzed by logistic regression to examine associations between MPNSTs and internal plexiform, superficial plexiform, subcutaneous, and cutaneous neurofibromas.
  • CONCLUSIONS: The observation that malignant peripheral nerve sheath tumors are strongly associated with internal plexiform neurofibromas suggests that patients with neurofibromatosis type 1 with these benign tumors warrant increased surveillance for malignancy.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurofibroma, Plexiform / epidemiology. Neurofibromatosis 1 / epidemiology. Peripheral Nerves / pathology
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Life Expectancy. Logistic Models. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Prevalence. Prognosis. Risk Factors. Survival Rate. Tomography, X-Ray Computed / adverse effects. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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  • (PMID = 16043787.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Kazakov DV, Ivan D, Kutzner H, Spagnolo DV, Grossmann P, Vanecek T, Sima R, Kacerovska D, Shelekhova KV, Denisjuk N, Hillen U, Kuroda N, Mukensnabl P, Danis D, Michal M: Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. Am J Dermatopathol; 2009 May;31(3):236-47
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  • [Title] Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation.
  • We present a series of 14 cases of cutaneous hidradenocarcinomas.
  • The patients included 6 women and 8 men ranging in age at diagnosis from 34 to 93 years.
  • There was no predilection site.
  • Grossly, the tumors ranged in size from 1.2 to 6 cm.
  • Microscopically, of the 14 primary tumors, 9 showed low-grade cytomorphology, whereas the remaining 5 neoplasms were high-grade lesions.
  • The cellular composition of the tumors varied slightly, with clear cells, epidermoid cells, and transitional forms being present in each case.
  • Despite the bland appearance, the tumor metastasized to a lymph node.
  • Of 10 primaries studied, 4 tumors showed positive p53 immunoreaction in more than 25% of the cells comprising the malignant portion of the lesions, in 2 cases, a minority of the neoplastic cells (10%-20%) demonstrated nuclear staining, whereas the remaining 4 cases were negative.
  • It is concluded that cutaneous hidradenocarcinomas show some microscopic heterogeneity and comprise both low- and high-grade lesions that cytologically are similar to their benign counterpart, the hidradenoma.
  • Within the spectrum of low-grade lesions, there seem to exist tumors almost indistinguishable from hidradenomas but still being capable of regional or distant metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Gene Amplification. Mutation. Receptor, ErbB-2 / genetics. Sweat Gland Neoplasms / pathology. Translocation, Genetic. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19384064.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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68. Allison KH, Patel RM, Goldblum JR, Rubin BP: Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis. Am J Clin Pathol; 2005 Nov;124(5):685-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis.
  • We reviewed the clinicopathologic features of 5 cases of malignant peripheral nerve sheath tumor (MPNST) manifesting in superficial locations associated with cutaneous neurofibromas (4 cases) or superficial peripheral nerve (1 case).
  • Four cases had spindle cell morphologic features and were at least focally positive for S-100 protein, whereas the associated benign neural elements had more extensive S-100 immunoreactivity.
  • Immunohistochemical markers are helpful in excluding other lesions in the differential diagnosis.
  • However, identification of a benign precursor or origin from a nerve may be the most definitive way to properly classify these rare lesions.
  • [MeSH-major] Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. S100 Proteins / analysis

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  • (PMID = 16203275.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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69. Morgan MB, Purohit C, Anglin TR: Immunohistochemical distinction of cutaneous spindle cell carcinoma. Am J Dermatopathol; 2008 Jun;30(3):228-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical distinction of cutaneous spindle cell carcinoma.
  • Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma in which keratinocytes infiltrate the dermis as single cells with elongated nuclei rather than as cohesive nests or islands, and signs of keratinization of conventional squamous cell carcinoma are insubstantial or nonexistent.
  • Spindle cell carcinoma must be distinguished from spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, atypical fibroxanthoma (AFX), and scar.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cicatrix / diagnosis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Keratinocytes / chemistry. Keratinocytes / pathology. Keratins / analysis. Leiomyosarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Predictive Value of Tests

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  • (PMID = 18496422.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CK-34 beta E12; 68238-35-7 / Keratins
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70. Bezdekova M, Brychtova S, Sedlakova E, Steigerova J, Hlobilkova A, Bienova M, Kucerova R, Brychta T, Krejci V, Kolar Z: Immunohistochemical assessment of E-cadherin and beta-catenin in trichofolliculomas and trichoepitheliomas. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2007 Dec;151(2):251-5
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  • [Title] Immunohistochemical assessment of E-cadherin and beta-catenin in trichofolliculomas and trichoepitheliomas.
  • BACKGROUND: Trichofolliculomas and trichoepitheliomas are benign skin neoplasms originating from hair follicle cells.
  • It is known that the E-cadherin/beta-catenin system of adhesion molecules plays a crucial role in the maintenance of tissue architecture.
  • AIM: The aim of the present study was to investigate their involvement in benign hair follicle tumor development.
  • METHODS: Semiquantitative intensity of expression were examined in formalin-fixed and paraffin-embedded tissue sections of 53 trichoepitheliomas, 15 trichofolliculomas and 19 normal skin samples by indirect immunohistochemistry.
  • RESULTS: The intensity of E-cadherin/beta-catenin expression in tumor cells did not differ from controls.
  • However, normal hair follicles cells exhibited membranous E-cadherin/beta-catenin expression, whereas both types of tumors, particularly trichoepitheliomas, showed E-cadherin/beta-catenin expression with a predominantly cytoplasmic localization.
  • CONCLUSIONS: We suggest that this dystopic distribution of the E-cadherin/beta-catenin complex in hair follicle tumor cells may be a marker of cell-cell adhesion disruption which may contribute to the tumor formation.
  • [MeSH-major] Cadherins / analysis. Hair Diseases / metabolism. Neoplasms, Basal Cell / chemistry. Skin Neoplasms / chemistry. beta Catenin / analysis

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  • (PMID = 18345259.001).
  • [ISSN] 1213-8118
  • [Journal-full-title] Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
  • [ISO-abbreviation] Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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71. Demirkan NC, Bir F, Erdem O, Düzcan E: Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors. J Cutan Pathol; 2007 Jun;34(6):467-73
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  • [Title] Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors.
  • The aim of this study was to determine the role of beta-catenin-related proteins in various benign trichogenic tumors.
  • METHODS: We investigated the expression of beta-catenin, E-cadherin, c-myc and cyclin D1 immunohistochemically, and the expression of these molecules were compared between two groups consisting of 12 PMXs and 12 other benign trichogenic tumors (OBTTs).
  • RESULTS: In PMX group, nuclear and/or cytoplasmic expression of beta-catenin was associated with a loss of membranous expression of E-cadherin (p = 0.002).
  • In OBTT group, a membranous expression of E-cadherin and beta-catenin was observed, and there was a stronger nuclear immunoreactivity of cyclin D1 compared with PMX group (p = 0.006).
  • [MeSH-major] Cadherins / metabolism. Cyclins / metabolism. Hair Diseases / metabolism. Pilomatrixoma / metabolism. Proto-Oncogene Proteins c-myc / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cyclin D. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 17518774.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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72. Magro CM, Dyrsen ME: Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates. J Cutan Pathol; 2008 Nov;35(11):1040-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates.
  • BACKGROUND: Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells.
  • It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function as a ligand for E-selectin expressed on cutaneous endothelial cells.
  • DESIGN: We investigated the expression of CLA using the HECA-452 antibody on paraffin-embedded, formalin-fixed tissue in a variety of reactive, neoplastic and preneoplastic cutaneous lymphoid infiltrates of T- and B-cell derivation.
  • A loss of CLA in tumors normally positive for CLA was a feature of disease progression best exemplified by tumor-stage MF and acute ATCLL.
  • CLA expression was not only observed in primary cutaneous anaplastic large cell lymphoma but also seen in cases of nodal anaplastic large cell lymphoma secondarily involving the skin and was negative in cases of nodal anaplastic large cell lymphoma without any established skin involvement.
  • An oligodot pattern defined a novel reaction pattern in those aggressive systemic dyscrasias with a proclivity to involve the skin.
  • CLA was negative in the majority of B-cell lymphomas.
  • CONCLUSIONS: CLA plays a role in the pattern of T-cell lymphocyte migration in the skin and subcutis in both reactive and neoplastic states.
  • An alteration in the expression of this marker, whether it is in the context of the acquisition of expression in a cell that is normally CLA negative or its loss of expression, may define a key event in determining cutaneous and extracutaneous hematopoietic cell distribution.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Dermatitis / immunology. Lymphoma, B-Cell / immunology. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell, Cutaneous / immunology. Skin Neoplasms / immunology

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  • (PMID = 18681860.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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73. Usmani N, Merchant W, Yung A: A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma. J Cutan Pathol; 2008 Mar;35(3):329-31
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  • [Title] A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma.
  • We describe the case of a cutaneous symplastic leiomyoma in a 37-year-old woman who presented with a 4-year history of a painful slow growing lesion on the left upper arm.
  • The diagnosis was felt to be in keeping with a cutaneous symplastic leiomyoma, a rarely reported variant of the pilar leiomyoma.
  • Although the long-term outlook is probably benign, the presence of cytological atypia and mitoses in any spindle cell tumor is generally a concerning feature and warrants long-term follow up.
  • [MeSH-major] Leiomyoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adult. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Desmin / analysis. Female. Humans. Treatment Outcome

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  • (PMID = 18251750.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin
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74. Wu Y, Zhang XB, Liu HJ, Zheng LD, Li JW, Lin Y: [Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Jul;36(7):466-9
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  • [Title] [Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma].
  • METHODS: Immunohistochemical study for CD10 and CD9 using Streptavidin-biotin complex technique was carried out in 48 cases of primary cutaneous malignant melanoma (CMM), 23 cases of metastatic melanoma and 23 cases of benign nevus.
  • RESULTS: The positivity rate of CD10 was highest in metastatic melanoma and lowest in benign nevus (P < 0.01).
  • The expression of CD10 and CD9 in CMM also correlated with tumor histology, Clark's level of invasion and presence of nodal metastasis.
  • [MeSH-major] Antigens, CD / metabolism. Melanoma / metabolism. Melanoma / pathology. Membrane Glycoproteins / metabolism. Neprilysin / metabolism. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD9. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 17845760.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; EC 3.4.24.11 / Neprilysin
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75. Calder KB, Khalil FK, Schlauder S, Cualing HD, Morgan MB: Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol; 2008 Dec;30(6):545-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of survivin in cutaneous sebaceous lesions.
  • Survivin overexpression has been demonstrated in numerous malignancies including cutaneous squamous cell carcinoma and melanoma.
  • To date, there are no studies evaluating the expression of survivin in sebaceous neoplasms.
  • METHODS: Immunohistochemical expression of survivin was evaluated in a total of 20 extraocular sebaceous neoplasms: sebaceous hyperplasia (SH, 8), sebaceous adenoma (SA, 8), and sebaceous carcinoma (SC, 4).
  • These findings demonstrate the potential diagnostic utility of survivin, further assisting in the microscopic differentiation of benign and malignant sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Adenoma / metabolism. Microtubule-Associated Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Nucleus / metabolism. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology. Inhibitor of Apoptosis Proteins / metabolism. Male. Middle Aged

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  • (PMID = 19033926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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76. Clarke LE, Lee R, Militello G, Elenitsas R, Junkins-Hopkins J: Cutaneous epithelioid hemangioendothelioma. J Cutan Pathol; 2008 Feb;35(2):236-40
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous epithelioid hemangioendothelioma.
  • Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor of endothelial cell origin.
  • We discuss the clinical and histopathologic differential diagnoses for these tumors and review additional cases in which EHE has been mistaken for benign entities clinically.
  • [MeSH-major] Diagnostic Errors. Foot Diseases / pathology. Hemangioendothelioma, Epithelioid / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Condylomata Acuminata / pathology. Diagnosis, Differential. Foreign-Body Reaction / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neuroma / pathology. Schizophrenia / pathology. Substance-Related Disorders. Tinea Pedis / pathology. Warts / pathology

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  • (PMID = 18190452.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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77. Di Cicilia R, Castellucci P, Nannini M, Balbi T, Zannetti G, Fanti S, Biasco G, Pantaleo MA: Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence. Clin Nucl Med; 2009 Oct;34(10):696-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence.
  • Granular cell tumor of Abrikossoff is a rare neoplasm that may occur in a wide variety of cutaneous and visceral sites.
  • Granular cell tumor generally shows benign behavior.
  • Until now, no data were available on the most useful imaging approach for diagnosis and staging.
  • We present a case of F-18 fluorodeoxyglucose positron emission tomography in Abrikossoff tumor, suggesting that F-18 fluorodeoxyglucose positron emission tomography may have a potential role in the management of this neoplasm.
  • [MeSH-major] Fluorodeoxyglucose F18. Granular Cell Tumor / radionuclide imaging. Melanoma / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Recurrence

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  • (PMID = 19893405.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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78. Cibull TL, Billings SD: Cutaneous malignant ossifying fibromyxoid tumor. Am J Dermatopathol; 2007 Apr;29(2):156-9
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  • [Title] Cutaneous malignant ossifying fibromyxoid tumor.
  • The tumor, partially surrounded by a shell of woven and lamellar bone, had a lobular arrangement of highly cellular islands of tumor cells embedded in a variably fibrous to myxoid stroma.
  • Areas of tumor necrosis were present.
  • The tumor was diagnosed as an ossifying fibromyxoid tumor (OFMT).
  • OFMT is a rare tumor first described in 1989.
  • Although OFMT usually occurs in deep soft tissue, up to 11% of reported lesions presented as cutaneous tumors.
  • Most are histologically bland and apparently benign tumors, but OFMT with high nuclear grade, high cellularity, and >2 MF/50 high-power fields have shown potential for aggressive behavior including metastasis.
  • Given the histologic features, this tumor was considered a malignant OFMT.
  • [MeSH-major] Buttocks. Fibroma / pathology. Neoplasms, Bone Tissue / pathology. Sarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Ossification, Heterotopic

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  • (PMID = 17414437.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Rahmah NN, Horiuchi T, Nakayama J, Nitta J, Hongo K: Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma? Surg Neurol Int; 2010;1:60

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  • [Title] Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?
  • BACKGROUND: The authors report a rare case of a patient with previously treated cutaneous malignant melanoma that recurred 1 year later as an intracranial meningioma.
  • The patient had a history of cutaneous malignant melanoma surgery on the same location 1 year before.
  • CONCLUSION: To our knowledge, this is a rare report of a patient with this tumor occurrence.
  • This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

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  • (PMID = 20975977.001).
  • [ISSN] 2152-7806
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2958332
  • [Keywords] NOTNLM ; Malignant melanoma / coexistence-losomarginal artery / meningioma / neural crest / recurrence
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80. Nonaka D, Chiriboga L, Rubin BP: Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors. J Cutan Pathol; 2008 Nov;35(11):1014-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors.
  • BACKGROUND: Desmoplastic melanoma (DM) may simulate various benign and malignant lesions, including benign peripheral nerve sheath tumors (BPNSTs) and malignant peripheral nerve sheath tumors (MPNSTs).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Melanoma / metabolism. Nerve Sheath Neoplasms / metabolism. S100 Proteins / metabolism. Skin Neoplasms / metabolism


81. Shin JU, Lee KY, Roh MR: A case of a cutaneous angiomyolipoma. Ann Dermatol; 2009 May;21(2):217-20

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  • [Title] A case of a cutaneous angiomyolipoma.
  • A cutaneous angiomyolipoma, which is also known as a cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor.
  • This is the 20th reported case of cutaneous angiomyolipoma and the 3rd reported case in Korea.

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  • [Cites] Am J Dermatopathol. 2005 Oct;27(5):418-21 [16148412.001]
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  • (PMID = 20523792.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2861200
  • [Keywords] NOTNLM ; Angiolipoleiomyoma / Angiomyolipoma
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82. Hoefnagel JJ, Mulder MM, Dreef E, Jansen PM, Pals ST, Meijer CJ, Willemze R, Vermeer MH: Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma. Mod Pathol; 2006 Sep;19(9):1270-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma.
  • Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with expression patterns during normal B-cell development.
  • Primary cutaneous large B-cell lymphomas, leg type showed aberrant coexpression of Bcl-6 and Mum1/IRF4 and in addition strong expression of FOXP1.
  • In contrast, primary cutaneous follicle center lymphomas showed expression of Bcl-6, Pax-5, PU.1, Oct2 and BOB.1, but not of Mum1/IRF4, Blimp-1 and FOXP1.
  • Primary cutaneous marginal zone B-cell lymphoma showed expression of Pax-5, PU.1, Oct2 and BOB.1, but not Bcl-6 by the neoplastic B-cells, and Mum1/IRF4 and Blimp-1 by the neoplastic plasma cells.
  • In conclusion, in primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell lymphoma expression patterns were observed similar to their supposed benign counterparts, germinal center B-cells and postgerminal center B-cells, respectively, which might reflect their indolent clinical behaviour and excellent prognosis.
  • In contrast, the activated B-cell expression pattern in the group of primary cutaneous large B-cell lymphoma, leg type may contribute to its poor prognosis and Mum1/IRF4 and FOXP1 may serve as additional diagnostic markers for this type of primary cutaneous B-cell lymphoma.
  • [MeSH-major] B-Lymphocytes / metabolism. Lymphoma, B-Cell / metabolism. Skin Neoplasms / metabolism. Transcription Factors / biosynthesis
  • [MeSH-minor] B-Cell-Specific Activator Protein / biosynthesis. Biomarkers, Tumor / biosynthesis. Biopsy. DNA-Binding Proteins / biosynthesis. Fluorescent Antibody Technique, Indirect. Forkhead Transcription Factors / biosynthesis. Germinal Center / metabolism. Germinal Center / pathology. Humans. Immunoenzyme Techniques. Interferon Regulatory Factors / biosynthesis. Octamer Transcription Factor-2 / biosynthesis. Palatine Tonsil / metabolism. Palatine Tonsil / pathology. Proto-Oncogene Proteins / biosynthesis. Repressor Proteins / biosynthesis. Trans-Activators / biosynthesis

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  • [Copyright] Published online 16 June 2006.
  • (PMID = 16778825.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / BCL6 protein, human; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / FOXP1 protein, human; 0 / Forkhead Transcription Factors; 0 / Interferon Regulatory Factors; 0 / Octamer Transcription Factor-2; 0 / PAX5 protein, human; 0 / POU2AF1 protein, human; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 0 / interferon regulatory factor-4; 0 / proto-oncogene protein Spi-1
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83. Craig S, Bui-Mansfield LT, Lusk JD: Radiology pathology conference of Brooke Army Medical Center: trichoblastoma of breast. Clin Imaging; 2009 Jul-Aug;33(4):311-3
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  • The differential diagnosis of a superficial breast lesion detected on mammography typically includes seborrheic keratosis, dermal nevus, epidermal inclusion cyst, and basal cell carcinoma with subcutaneous invasion [Kopans DB.
  • Trichoblastoma is a benign skin neoplasm that is rarely found in the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography / methods

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  • (PMID = 19559355.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Saad AG, Mutema GK, Mutasim DF: Benign cutaneous epithelioid Schwannoma: case report and review of the literature. Am J Dermatopathol; 2005 Feb;27(1):45-7
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  • [Title] Benign cutaneous epithelioid Schwannoma: case report and review of the literature.
  • Benign peripheral nerve sheath tumors are relatively common.
  • Although variants with epithelioid foci can be present, the pure epithelioid variant of benign cutaneous schwannoma is extremely rare.
  • It was first reported as cutaneous epithelial schwannoma by Kindblom et al in 1998.
  • Care should be taken not to misdiagnose them as malignant neoplasms.
  • Their diagnosis can be problematic as their histopathologic features may overlap with those of other soft-tissue and melanocytic tumors.
  • We report a case of cutaneous epithelioid schwannoma and review of the literature.
  • [MeSH-major] Epithelioid Cells / pathology. Neurilemmoma / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Middle Aged

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  • (PMID = 15677978.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 3
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85. Lucas A, Betlloch I, Planelles M, Martínez T, Pérez-Crespo M, Mataix J, Belinchón I: Non-melanocytic benign skin tumors in children. Am J Clin Dermatol; 2007;8(6):365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-melanocytic benign skin tumors in children.
  • BACKGROUND: Dermatologists often attend children with benign skin tumors and cysts.
  • The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors.
  • OBJECTIVE: The objective of this study was to determine the nature of non-melanocytic benign skin tumors amenable to dermatologic surgery in children.
  • METHODS: Histopathologic studies of skin tumors in children treated by our department between January 2004 and December 2005 were studied.
  • Malignant and melanocytic tumors were excluded.
  • Age, sex, type of tumor, diagnostic category, site, size, reason for removal, type of anesthesia, and any other associated disorders were recorded.
  • RESULTS: The records revealed that 121 patients presented 129 non-melanocytic benign skin tumors (73 in boys and 56 in girls).
  • Tumors were located on the head and neck (45.7%), trunk (34.1%), and limbs (20.1%).
  • The reasons that led to removal of the tumors were: increase in the size of the tumor (49%); various types of discomfort, such as severe itching or pain (30%); parental concern (4%); diagnostic uncertainty (16%); and esthetic reasons (1%).
  • CONCLUSION: There is a wide diversity of non-melanocytic benign skin tumors in children, some of which require surgical treatment.
  • Pilomatrixomas appear to be the most frequent benign tumors; there are also high frequencies of infundibular cysts, pyogenic granulomas, and viral tumors.
  • [MeSH-major] Skin Neoplasms / pathology

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  • (PMID = 18039019.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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86. Grzanka AA, Placek W, Grzanka A, Sokolowska-Wojdylo M, Zuryn A: Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors. Neoplasma; 2010;57(1):41-6
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors.
  • Mycosis fungoides is an epidermotropic cutaneous T-cell lymphoma (CTCL).Specimens for presented study were taken from sixteen patients with MF confirmed by immunohistochemical methods and PCR and from nine patients with benign dermatoses.
  • We saw morphological differences between lymphocytes from MF and benign dermatoses.
  • In MF tumor stage labelling decreased in following order: CD7, CD3 and CD4.
  • We also found internalisation of studied antigens via the coated structures of the cell membrane -especially in tumor stage.
  • In benign dermatoses the majority of all receptors was present on the cell membrane.
  • We also found loss of CD3 and CD7 antigens in tumor stage what might be use as adiagnosis tool for this disease.
  • KEYWORDS: mycosis fungoides, benign dermatoses, CD3, CD4 and CD7 receptors, immumogold labelling.
  • [MeSH-major] Antigens, CD3 / analysis. Antigens, CD4 / analysis. Antigens, CD7 / analysis. Mycosis Fungoides / immunology. Skin Diseases / immunology. Skin Neoplasms / immunology

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  • (PMID = 19895171.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD4; 0 / Antigens, CD7
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87. Parente P, Coli A, Massi G, Mangoni A, Fabrizi MM, Bigotti G: Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. J Exp Clin Cancer Res; 2008;27:34
MedlinePlus Health Information. consumer health - Melanoma.

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  • [Title] Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions.
  • This study was undertaken to assess the differential expression of Glut-1 and Glut-3 by benign and malignant melanocytic lesions.
  • METHODS: Immunohistochemical staining for Glut-1 and Glut-3 was performed on paraffin-embedded tissue sections prepared from melanocytic nevi (12 cases), Spitz nevi (12 cases) and primary cutaneous malignant melanomas (20 cases).
  • RESULTS: We observed immunoreactivity for Glut-1 in all melanocytic nevi, 9 of the 12 Spitz nevi and in 9 of the 20 malignant melanomas, whereas Glut-3 was expressed in all the melanocytic lesions, both benign and malignant.
  • Glut-1 was present in the majority of benign nevi, whereas its expression was downregulated in 55% of malignant melanomas.
  • Our results suggest that glucose transporter Glut-1 expression can significantly discriminate between human malignant melanoma and benign melanocytic nevi, and support the idea that additional mechanisms other than Glut-1 may contribute to glucose uptake in melanomas.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Immunohistochemistry

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  • (PMID = 18764953.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / Glucose Transporter Type 3
  • [Other-IDs] NLM/ PMC2553059
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88. Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Tu YT, Furue M, Moroi Y: Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol; 2008 Aug;35(8):722-30
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  • [Title] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma.
  • BACKGROUND: Activating transcription factor-2/Activator protein-1 (AP-1), Signal transducer and activator of transcription-3 and p53 are important regulators of cellular proliferation, apoptosis, differentiation in the pathogenesis of many human tumors, but the expression of phosphorylated (p)-activating transcription factor-2 (p-ATF2), phosphorylated (p)-signal transducer and activator of transcription-3 (p-STAT3) and p53 family (p63 and p73) has not been investigated in cutaneous angiosarcoma (CAS) and pyogenic granuloma (PG) so far.
  • OBJECTIVES: To investigate the expression of p-ATF2, p-STAT3 and p53 and its family in cutaneous vascular tumors (CAS and PG).
  • The p-ATF2-, p-STAT3- and p53 expression (% positive cells) in CAS and PG were significantly higher than in normal dermal vessels, but none of these transcription factors distinguished malignant (CAS)- from benign (PG) vascular tumor.
  • CONCLUSIONS: The present study suggests that overexpression of p-ATF2, p-STAT3 and possibly p53, but not p63 or p73, may contribute to the tumorigenesis of cutaneous vascular tumors.
  • [MeSH-major] Activating Transcription Factor 2 / biosynthesis. Gene Expression Regulation, Neoplastic. Granuloma, Pyogenic / metabolism. Hemangiosarcoma / metabolism. STAT3 Transcription Factor / biosynthesis. Skin Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis


89. Cooper JZ, Newman SR, Scott GA, Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases. Dermatol Surg; 2005 Feb;31(2):221-5; discussion 225
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  • [Title] Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is an unusual malignant fibrohistiocytic tumor of sun-damaged skin.
  • When first described, it was felt to be a reactive tumor of low malignant potential.
  • More recently, it has been shown to be a tumor of intermediate malignant potential.
  • Also, three of the five cases had other aggressive cutaneous malignancies.
  • LN-2 (CD74) staining was positive in three of five primary tumors and two of five metastatic tumors.
  • LN-2 staining may be a useful marker in identifying more aggressive tumor behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Face / pathology. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Metastasis. Scalp / pathology. Upper Extremity / pathology

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  • (PMID = 15762219.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Busam KJ: Cutaneous desmoplastic melanoma. Adv Anat Pathol; 2005 Mar;12(2):92-102
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  • [Title] Cutaneous desmoplastic melanoma.
  • It most often presents as an indurated lesion in chronically sun-damaged skin.
  • At the time of excision, the tumors usually extend into the reticular dermis or deeper.
  • It may simulate histologically sclerosing melanocytic nevi as well as various benign and malignant nonmelanocytic lesions.
  • There is significant morphologic variability among tumors classified as DM.
  • Desmoplasia may be prominent throughout the entire tumor ("pure" DM) or represent a portion of an otherwise nondesmoplastic melanoma ("combined" DM).
  • Some tumors show neuroma-like features with prominent nerve involvement, in which case the term "desmoplastic neurotropic melanoma" is used.
  • Evidence is also emerging that for patients with thick melanomas, the presence of a paucicellular fibrosing tumor histology (pure DM) is a favorable prognostic factor for survival.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Fibrosis. Humans. Neoplasm Recurrence, Local. Nevus, Pigmented / diagnosis. S100 Proteins / analysis. Sunlight / adverse effects

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  • (PMID = 15731577.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
  • [Number-of-references] 56
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91. Hafner C, Vogt T, Hartmann A: FGFR3 mutations in benign skin tumors. Cell Cycle; 2006 Dec;5(23):2723-8
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  • [Title] FGFR3 mutations in benign skin tumors.
  • Recently, the same FGFR3 mutations known from skeletal dysplasia syndromes and urothelial carcinoma have been shown to cause benign human skin tumors such as seborrheic keratoses and epidermal nevi.
  • The underlying mechanisms for the somatic FGFR3 mutations in the epidermis are unknown so far, as well as details of the involved signaling pathways in the mutant keratinocytes leading to the formation of acanthotic skin tumors.
  • Herein we discuss potential mechanisms and functional consequences of activating FGFR3 mutations in human skin.
  • Further studies are required to provide insights in the pathogenesis of benign skin tumors caused by FGFR3 mutations.
  • These studies will add to new non-invasive therapeutical strategies for benign acanthotic skin tumors in dermatology.
  • [MeSH-major] Mutation / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics

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  • (PMID = 17172848.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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92. Dorić M, Radović S, Kuskunović S, Hukić A, Babić M, Tomić I, Selak I: Dermal squamomelano-cytic tumor: neoplasm of uncertain biological potential. Bosn J Basic Med Sci; 2008 May;8(2):152-5
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  • [Title] Dermal squamomelano-cytic tumor: neoplasm of uncertain biological potential.
  • We report a case of exceedingly rare cutaneous neoplasm with histological features of malignancy and uncertain biological potential.
  • The nodular, darkly pigmented facial tumor with central exulceration, size 12 x 10 x 7 mm, of the skin 61-year-old man preauricular left was completely exised.
  • Histologically tumor consists of atypical squamous cells, which express signs of moderate to significant pleomorphism, mitotically active, with foci forming of parakeratotic horn cysts ("pearls").
  • Characteristically tumor also consists of large number of atypical melanocytes with multifocal pattern, inserted between atypical squamous cells, and which contain large amount of dark brown pigment melanin.
  • The follow-up time of four years no evidence of recurrence or metastasis, similar all reported cases, but it is too short period in estimation to guarantee a benign course.
  • However, it appears that this group of neoplasm may have different prognosis from pure squamous carcinoma or malignant melanoma.

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  • (PMID = 18498266.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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93. Florell SR, Cessna M, Lundell RB, Boucher KM, Bowen GM, Harris RM, Petersen MJ, Zone JJ, Tripp S, Perkins SL: Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates. Am J Clin Pathol; 2006 May;125(5):727-36
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  • [Title] Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates.
  • Our purpose was to evaluate the interobserver concordance for the diagnoses of mycosis fungoides (MF), atypical dermatoses (AD), and benign dermatoses (BD) and the impact of T-cell immunophenotyping on the diagnoses MF, AD, and BD.
  • Specimens of MF (n = 57), AD (n = 27), BD and normal skin (n = 54) were reviewed by 2 hematopathologists and 1 dermatopathologist to establish diagnostic interobserver concordance by routine morphologic examination.
  • The interobserver concordance was fair to moderate compared with the original diagnosis.
  • Immunophenotyping generally resulted in downgrading of the reaction pattern but was helpful in distinguishing MF from benign dermatoses.
  • [MeSH-major] Immunophenotyping. Leukemic Infiltration / diagnosis. Mycosis Fungoides / diagnosis. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Biomarkers, Tumor / metabolism. CD4-CD8 Ratio. Female. Humans. Male. Middle Aged. Observer Variation. ROC Curve. Reproducibility of Results

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  • (PMID = 16707374.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K23 RR 17525-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor
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94. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
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  • [Title] Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis.
  • BACKGROUND: The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities.
  • METHODS: We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal neoplasms.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry
  • [MeSH-minor] Boston. Cell Lineage. Diagnosis, Differential. Humans. Immunohistochemistry. Nestin. Predictive Value of Tests

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  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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95. Kanner WA, Brill LB 2nd, Patterson JW, Wick MR: CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol; 2010 Jul;37(7):744-50
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  • [Title] CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is a pleomorphic spindle cell lesion of the skin; it is considered in the differential diagnosis with spindle cell malignant melanoma (MM) and sarcomatoid carcinoma/spindle cell squamous cell carcinoma (SCC).
  • CD10 positivity was preferentially associated with the diagnosis of AFX (p < 0.001).
  • CONCLUSION: CD10 positivity is relatively specific in this context for the diagnosis of AFX.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD / biosynthesis. Cell Adhesion Molecules / biosynthesis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Membrane Proteins / biosynthesis. Middle Aged. Neprilysin / biosynthesis

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  • (PMID = 20184665.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / CKAP4 protein, human; 0 / Cell Adhesion Molecules; 0 / Membrane Proteins; EC 3.4.24.11 / Neprilysin
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96. Adler N, Tsabari C, Sulkes J, Ad-El D, Feinmesser M: Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma protuberans. J Cutan Pathol; 2008 Jun;35(6):532-5
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  • Findings within the tumors were compared with fibrocyte staining in adjacent tissue.
  • The prominent expression of COX-2 in DFSP may have clinical implications for treatment with COX-2 inhibitors in tumors that are not amenable to surgery.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Dermatofibrosarcoma / enzymology. Histiocytoma, Benign Fibrous / enzymology. Skin Neoplasms / enzymology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans

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  • (PMID = 18201240.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2
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97. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations.
  • Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in areas with a high density of eccrine sweat glands, like the palms or soles.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Only after histopathologic examination were they classified as eccrine porocarcinoma, showing features of epithelial tumors with abortive ductal differentiation.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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98. Labonte S, Hanna W, Bandarchi-Chamkhaleh B: A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma. J Cutan Pathol; 2007 Nov;34(11):857-60
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  • BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon spindle cell tumor of the skin.
  • There are case reports of partial response of DFSP to the tyrosine kinase inhibitor STI571 (Imatinib), despite the reported negativity of the tumor cells for CD117.
  • METHODS: Thirty-seven cases of clear-cut DFSP and 13 cases of clear-cut CDF were retrieved from the archives of Sunnybrook Health Sciences Center between 2000 and 2005.
  • [MeSH-major] Dermatofibrosarcoma / metabolism. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism

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  • (PMID = 17944726.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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99. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Studies have suggested that human papillomavirus or a benign clonal proliferation of epidermal cells is involved in the pathogenesis of some SK's, however, this issue remains to be resolved.

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
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  • [Title] Clear cell hidradenoma: a mimic of metastatic clear cell tumors.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Furthermore, immunohistochemical studies can aid in distinguishing the 2 tumors.
  • Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation.
  • Detailed clinical history, physical findings, and ancillary studies are essential for correct diagnosis and categorization of these tumors.
  • We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Axilla. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymph Nodes / surgery. Male. Middle Aged. Mitotic Index. Neoplasm Metastasis / diagnosis. Treatment Outcome

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  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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