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1. Hussein MR, Elsers DA, Fadel SA, Omar AE: Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions. J Clin Pathol; 2006 Mar;59(3):316-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions.
  • BACKGROUND: Although the presence of tumour infiltrating lymphocytes (TIL) is a constant feature in melanomas, their immunophenotypic characterisation is still incomplete.
  • We hypothesise that the transition from normal skin to benign naevi (BN) to melanocytic dysplastic naevi (MDN) to radial growth phase cutaneous malignant melanoma (RGP-CMM) to vertical growth phase cutaneous malignant melanoma (VGP-CMM) is associated with alterations in TIL.
  • This study attempted to test this hypothesis and to characterise TIL in the melanocytic skin lesions.
  • RESULTS: Histologically, the transitions from normal skin to BN to MDN to RGP-CMM to VGP-CMM was associated with a gradual increase in the numbers of TIL (total, parenchymal, stromal, perivascular, and epidermal TIL, as well as TIL at the base of the lesions).
  • All these differences between the normal skin and the lesional ones reached statistical significance (p<0.01).
  • CONCLUSIONS: The gradual increase in TIL during melanoma tumorigenesis may reflect increased antigenicity of the tumour cells.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lymphocytes, Tumor-Infiltrating / pathology. Melanocytes / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Analysis of Variance. Antigens, CD20 / analysis. Antigens, CD3 / analysis. Antigens, CD45 / analysis. Case-Control Studies. Disease Progression. Humans. Immunohistochemistry / methods. Immunophenotyping. Lymphocyte Count. Neoplasm Staging. Nevus / immunology. Nevus / pathology. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 16505286.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD3; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC1860334
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2. Abalo-Lojo JM, Cameselle-Teijeiro J, Gonzalez F: Pilomatrixoma: late onset in two periocular cases. Ophthal Plast Reconstr Surg; 2008 Jan-Feb;24(1):60-2
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  • First described by Malherbe and Chenantais in 1880, pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • It is typically a tumor of younger individuals and rarely presents in older patients.
  • [MeSH-major] Eyelid Neoplasms / pathology. Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18209650.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Golpour M: Evaluation of characteristics of patients with pilomatricoma in Mazandaran Province, 1996-2006. Pak J Biol Sci; 2009 Mar 15;12(6):548-50
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  • Mean age of the patients was 20.1 years .The most frequent sites of the tumor were the forearm (41.30%).
  • It can be concluded, because the pilomatricoma is a benign cutaneous neoplasm with differentiation toward hair matrix, so that it is not seen in palm or plantar surface, but could present in any other area.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19580010.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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4. Garrido-Ruiz MC, Carrillo R, Enguita AB, Peralto JL: Signet-ring cell dermatofibroma. Am J Dermatopathol; 2009 Feb;31(1):84-7
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  • Dermatofibroma or cutaneous fibrous histiocytoma is a common benign skin lesion with multiple, distinct histologic variants, including cellular, aneurismal, epithelioid, atypical, lipidized "ankle-type," palisading, and cholesterotic.
  • Although dermatofibromas are considered benign neoplasms, certain variants including cellular and aneurismal ones have shown to have a notable tendency to locally recur after excision.
  • The finding of signet-ring cells in a skin neoplasm always raises the suspicion of metastatic adenocarcinoma, although a number of reports have shown their occurrence in primitive cutaneous neoplasms as well.
  • We present, for the first time, a new, distinctive variant of dermatofibroma, so-called signet-ring cell dermatofibroma, in a 16-year-old man with a slowly growing skin tumor on the lateral side of his right leg.
  • Histochemical and immunohistochemical stainings confirmed the diagnosis of dermatofibroma.
  • The phenomenon described in this case enlarges the histologic spectrum of cutaneous fibrous histiocytoma and may cause substantial differential diagnostic problems.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19155733.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Demirseren ME, Afandiyev K, Ceran C: Reconstruction of the perioral and perinasal defects with facial artery perforator flaps. J Plast Reconstr Aesthet Surg; 2009 Dec;62(12):1616-20
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  • Twelve clinical cases with 14 perioral and perinasal skin defects resulting from malignant or benign skin tumour excision were reconstructed using facial artery perforator flaps.
  • The donor-site scars were designed parallel to the facial wrinkles when possible.
  • The aesthetically pleasing donor site based on the facial artery perforators offers a versatile tailor-made flap, because of the reliable presence of perforators, with a large arc of rotation.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Esthetics. Face / blood supply. Female. Humans. Male. Middle Aged. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Nose Neoplasms / pathology. Nose Neoplasms / surgery. Treatment Outcome


6. Seyfarth HJ, Wirtz H, Borte G, Gradistanac T, Gessner C, Hammerschmidt S: [Ultrasound guided transthoracic biopsy - safety and efficaces]. Pneumologie; 2007 Sep;61(9):563-7
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  • BACKGROUND: The biopsy of pulmonary neoplasms localized in close proximity of the thoracic wall and the histological examination of the specimens represent an important diagonstic tool in the work up of benign and malign pulmonary tumours.
  • 43 pulmonary or pleural and 3 mediastinal neoplasms were investigated.
  • The neoplasm reached the pleura in 41 cases.
  • RESULTS: The histological examination provided the diagnosis in 44 of 46 cases (95.6 %): lung cancer n = 29, other malign tumours n = 9; benign tumours n = 6).
  • Complications were observed in three patients: haemoptysis, cutaneous emphysema (without need for intervention), pneumothorax with consecutive chest tube placement (one case each).
  • [MeSH-major] Biopsy, Needle / methods. Lung Neoplasms / pathology. Lung Neoplasms / ultrasonography. Pulmonary Disease, Chronic Obstructive / pathology. Pulmonary Disease, Chronic Obstructive / ultrasonography. Ultrasonography, Interventional / methods

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  • (PMID = 17602390.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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7. Massi D, Landriscina M, Piscazzi A, Cosci E, Kirov A, Paglierani M, Di Serio C, Mourmouras V, Fumagalli S, Biagioli M, Prudovsky I, Miracco C, Santucci M, Marchionni N, Tarantini F: S100A13 is a new angiogenic marker in human melanoma. Mod Pathol; 2010 Jun;23(6):804-13
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  • S100A13 is upregulated in astrocytic gliomas, in which it correlates with VEGF-A expression, microvessel density and tumor grading, and promotes a more aggressive, invasive phenotype in lung cancer-derived cell lines.
  • To investigate the involvement of S100A13 in human cutaneous melanoma, we analyzed a series of 87 cutaneous melanocytic lesions: 14 common acquired melanocytic nevi, 14 atypical, so-called 'dysplastic' nevi, 45 melanomas (17 radial growth phase and 28 vertical growth phase) and 14 melanoma metastases.
  • We found that S100A13 was expressed in melanocytic lesions; compared with benign nevi, S100A13 protein expression was significantly upregulated in melanomas (P=0.024), in which it correlated positively with the intensity of VEGF-A staining (P=0.041) and microvessel density (P=0.007).
  • In conclusion, S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth.
  • [MeSH-major] Biomarkers, Tumor / analysis. Capillaries / chemistry. Melanoma / blood supply. Melanoma / chemistry. Neovascularization, Pathologic / metabolism. S100 Proteins / analysis. Skin Neoplasms / blood supply. Skin Neoplasms / chemistry
  • [MeSH-minor] Aged. Antigens, CD / analysis. Female. Fibroblast Growth Factor 1 / analysis. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Prognosis. RNA, Messenger / analysis. Receptors, Cell Surface / analysis. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 20208480.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL035627; United States / NHLBI NIH HHS / HL / R01 HL035627; United States / NHLBI NIH HHS / HL / R01 HL035627-23
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / ENG protein, human; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / S100 Proteins; 0 / S100A13 protein, human; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 104781-85-3 / Fibroblast Growth Factor 1
  • [Other-IDs] NLM/ NIHMS204422; NLM/ PMC2882157
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8. Yamamoto Y, Nakamine H, Nakamura S: Recurrent primary cutaneous large B-cell lymphoma after a long-term remission. Pathol Int; 2006 Oct;56(10):645-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent primary cutaneous large B-cell lymphoma after a long-term remission.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD20 / genetics. Antigens, CD20 / metabolism. Antigens, CD79 / genetics. Antigens, CD79 / metabolism. Gene Expression Regulation, Neoplastic / genetics. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans. Male. Proto-Oncogene Proteins c-bcl-2 / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism. Remission Induction. Time Factors

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  • (PMID = 16984625.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / Proto-Oncogene Proteins c-bcl-2
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9. Lucas A, Betlloch I, Planelles M, Martínez T, Pérez-Crespo M, Mataix J, Belinchón I: Non-melanocytic benign skin tumors in children. Am J Clin Dermatol; 2007;8(6):365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-melanocytic benign skin tumors in children.
  • BACKGROUND: Dermatologists often attend children with benign skin tumors and cysts.
  • The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors.
  • OBJECTIVE: The objective of this study was to determine the nature of non-melanocytic benign skin tumors amenable to dermatologic surgery in children.
  • METHODS: Histopathologic studies of skin tumors in children treated by our department between January 2004 and December 2005 were studied.
  • Malignant and melanocytic tumors were excluded.
  • Age, sex, type of tumor, diagnostic category, site, size, reason for removal, type of anesthesia, and any other associated disorders were recorded.
  • RESULTS: The records revealed that 121 patients presented 129 non-melanocytic benign skin tumors (73 in boys and 56 in girls).
  • Tumors were located on the head and neck (45.7%), trunk (34.1%), and limbs (20.1%).
  • The reasons that led to removal of the tumors were: increase in the size of the tumor (49%); various types of discomfort, such as severe itching or pain (30%); parental concern (4%); diagnostic uncertainty (16%); and esthetic reasons (1%).
  • CONCLUSION: There is a wide diversity of non-melanocytic benign skin tumors in children, some of which require surgical treatment.
  • Pilomatrixomas appear to be the most frequent benign tumors; there are also high frequencies of infundibular cysts, pyogenic granulomas, and viral tumors.
  • [MeSH-major] Skin Neoplasms / pathology

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  • (PMID = 18039019.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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10. Badeloe S, Frank J: Clinical and molecular genetic aspects of hereditary multiple cutaneous leiomyomatosis. Eur J Dermatol; 2009 Nov-Dec;19(6):545-51
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  • [Title] Clinical and molecular genetic aspects of hereditary multiple cutaneous leiomyomatosis.
  • Multiple cutaneous and uterine leiomyomatosis syndrome (MCUL; OMIM 150800) is an autosomal dominantly inherited tumor predisposition disorder, characterized by leiomyomas of the skin and uterus.
  • Cutaneous leiomyoma can easily be recognized and confirmed by histological examination.
  • Recognition of these benign skin tumors can lead to the diagnosis of MCUL or HLRCC.
  • Timely diagnosis is crucial for offering affected individuals and families potentially life-saving regular prophylactic screening examinations for renal tumors.
  • Here we provide an overview of clinical and genetic features of this complex tumor syndrome and discuss patient management and current therapeutic strategies.
  • [MeSH-minor] Biomarkers / metabolism. Biopsy. Diagnosis, Differential. Female. Genetic Counseling. Genetic Predisposition to Disease. Humans. Kidney Neoplasms / genetics. Metabolism, Inborn Errors / genetics. Skin Neoplasms / genetics. Uterine Neoplasms / genetics

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  • (PMID = 19939761.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers; EC 4.2.1.2 / Fumarate Hydratase
  • [Number-of-references] 99
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11. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • The specimens consisted of 17 cases of soft tissue leiomyosarcoma (LMS), 4 cases of cutaneous LMS, 22 cases of conventional malignant fibrous histiocytoma (MFH) and 2 cases of angiomatoid fibrous histiocytoma.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • This locus may point to the existence of a genetically altered tumour suppressor gene involved in the pathogenesis of LMS and MFH.
  • Our results support the hypothesis that MFHs may represent a morphological pathway in tumour progression of LMSs.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Allelic Imbalance. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Nerve Sheath Neoplasms / genetics. Polymerase Chain Reaction. Sarcoma, Synovial / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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12. Miracco C, De Nisi MC, Arcuri F, Cosci E, Pacenti L, Toscano M, Lalinga AV, Biagioli M, Rubegni P, Vatti R, Maellaro E, Del Bello B, Massi D, Luzi P, Tosi P: Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours. Int J Oncol; 2006 Feb;28(2):345-52
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  • [Title] Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours.
  • Although MIF's functions in cancer have not been completely elucidated, its expression has usually been correlated with tumour progression and aggressiveness, and it is currently discussed as a new promising target for novel therapies.
  • We evaluated MIF protein expression in 126 skin lesions, including benign and atypical nevi, melanoma and melanoma metastases.
  • Benign nevi were subdivided into nevocytic and Spitz/blue types; and melanomas into the radial, and vertical growth phase.
  • All samples expressed MIF mRNA but it was significantly lower in benign nevi vs atypical nevi, melanomas and metastases (p=0.001; p<0.0001; p=0.002, respectively).
  • Whereas we observed a trend towards higher expression levels of mRNA in atypical and malignant tumours, MIF protein was highly expressed in all lesions, although limited to the cytoplasm in most benign nevi.
  • These observations suggest differences in MIF protein storage, subcellular location and properties in most benign nevi vs atypical and malignant tumours that should be confirmed by further investigation and correlation with clinical outcome.
  • [MeSH-major] Macrophage Migration-Inhibitory Factors / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. RNA, Messenger / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Nucleus / metabolism. Cytoplasm / metabolism. Humans. Immunohistochemistry. Neoplasm Metastasis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16391788.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Macrophage Migration-Inhibitory Factors; 0 / RNA, Messenger
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13. Alexis AF, Sergay AB, Taylor SC: Common dermatologic disorders in skin of color: a comparative practice survey. Cutis; 2007 Nov;80(5):387-94
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  • [Title] Common dermatologic disorders in skin of color: a comparative practice survey.
  • There is a paucity of data on the epidemiology of dermatologic disease in populations with skin of color.
  • We reviewed the diagnosis codes of 1412 patient visits from August 2004 through July 2005 at the Skin of Color Center at St. Luke's-Roosevelt Hospital Center, in New York.
  • During visits by black patients, the 5 most common diagnoses observed at our center were acne (ICD-9 [International Classification of Diseases, Ninth Revision] 706.1); dyschromia (ICD-9 709.09); contact dermatitis and other eczema, unspecified cause (ICD-9 692.9); alopecia (ICD-9 704.0); and seborrheic dermatitis (ICD-9 690.1).
  • During visits by white patients, the 5 most common diagnoses recorded were acne (ICD-9 706.1); lesion of unspecified behavior (ICD-9 238.2); benign neoplasm of skin of trunk (ICD-9 216.5); contact dermatitis and other eczema, unspecified cause (ICD-9 692.9); and psoriasis (ICD-9 696. 1).
  • [MeSH-major] Skin Diseases / diagnosis. Skin Diseases / ethnology
  • [MeSH-minor] Acne Vulgaris / diagnosis. Acne Vulgaris / ethnology. African Continental Ancestry Group. Dermatitis, Contact / diagnosis. Dermatitis, Contact / ethnology. Dermatitis, Seborrheic / diagnosis. Dermatitis, Seborrheic / ethnology. Eczema / diagnosis. Eczema / ethnology. European Continental Ancestry Group. Humans. Psoriasis / diagnosis. Psoriasis / ethnology. Retrospective Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / ethnology

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  • (PMID = 18189024.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Saikali S, Paumier V, Garrelon JL, Le Gall F: [Facial primary cutaneous ganglioneuroma]. Ann Pathol; 2009 Apr;29(2):138-41
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  • [Title] [Facial primary cutaneous ganglioneuroma].
  • [Transliterated title] Ganglioneurome cutané primitif de la face.
  • Ganglioneuroma is a benign neoplasm of the sympathetic nervous system most often arising in the posterior mediastinum, retroperitoneum, adrenal medulla and pelvis.
  • The occurrence of ganglioneuroma in the skin is rare with only 10 cases reported in the literature.
  • [MeSH-major] Ganglioneuroma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19364589.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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15. Bales E, Mills L, Milam N, McGahren-Murray M, Bandyopadhyay D, Chen D, Reed JA, Timchenko N, van den Oord JJ, Bar-Eli M, Keyomarsi K, Medrano EE: The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer Res; 2005 Feb 1;65(3):692-7
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  • Here we analyzed such expression in more detail and show that cyclin E is overexpressed and present in low molecular weight (LMW) isoforms in metastatic melanoma and in a subset of primary invasive melanoma tumor tissues, but not in benign nevi.
  • The biological significance of these findings was established by showing that overexpression of two LMW cyclin E forms named cyclin E truncated 1 [cyclinE(T1)] and cyclin E truncated 2 [cyclinE(T2)] in a low tumorigenic and non-metastatic primary cutaneous melanoma cell line generated angiogenic tumors with prominent perineural invasion compared with full-length cyclin E.
  • Together, these results indicate that the LMW cyclin E forms are functional and likely act as regulators of human melanoma tumor progression and invasion.
  • [MeSH-minor] Animals. Blotting, Western. CDC2-CDC28 Kinases / metabolism. Cell Cycle Proteins / metabolism. Cyclin-Dependent Kinase 2. Cyclin-Dependent Kinase Inhibitor p21. Humans. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Molecular Weight. Neoplasm Metastasis. Neoplasm Transplantation. Neovascularization, Pathologic / metabolism. Protein Isoforms. Transfection. Transplantation, Heterologous

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  • (PMID = 15705861.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cdkn1a protein, mouse; 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Protein Isoforms; EC 2.7.11.22 / CDC2-CDC28 Kinases; EC 2.7.11.22 / CDK2 protein, human; EC 2.7.11.22 / Cdk2 protein, mouse; EC 2.7.11.22 / Cyclin-Dependent Kinase 2
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16. Hsieh TJ, Wang CK, Tsai KB, Chen YW: Pilomatricoma: magnetic resonance imaging and pathological evaluation. J Comput Assist Tomogr; 2008 Mar-Apr;32(2):320-3
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  • Pilomatricoma is an asymptomatic, slowly growing, benign skin tumor that is typically located in the regions of head and neck.
  • Our case revealed late enhancement in the dynamic magnetic resonance imaging study that is a common pattern more in a benign soft tissue tumor and caused dramatic uptake in the bone scintigraphy.
  • [MeSH-major] Hair Diseases / diagnosis. Magnetic Resonance Imaging / methods. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18379325.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Presutti L, Alicandri-Ciufelli M, Mattioli F, Marchioni D, Costantini M: A case of syryngocystadenoma papilliferum (SCAP) involving middle ear, presenting with otomastoiditis and cerebral abscess. Auris Nasus Larynx; 2008 Sep;35(3):401-3
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  • Syryngocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal neoplasm of apocrine gland origin.
  • We describe a case of SCAP of external and middle ear, presenting with otomastoiditis and cerebral abscess; this aggressive behavior, never reported for a benign adenoma of the external or middle ear, could lead to a differential diagnosis with cholesteatoma or malignancies.
  • [MeSH-major] Ear, Middle. Empyema, Subdural / etiology. Mastoiditis / etiology. Streptococcal Infections / etiology. Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis. Temporal Lobe
  • [MeSH-minor] Adult. Cholesteatoma, Middle Ear / diagnosis. Chronic Disease. Diagnosis, Differential. Epilepsy, Tonic-Clonic / etiology. Fever of Unknown Origin / etiology. Humans. Male. Mastoid / pathology. Mastoid / surgery. Otitis Media / pathology. Otitis Media / surgery. Tomography, X-Ray Computed

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  • (PMID = 17870265.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Brailey LL, Davis T, Kolker SE, Murry TC, Thomas D, Bale AE, Ruhoy SM: Congenital linear unilateral basal cell nevus: a case report with patched gene molecular studies. J Cutan Pathol; 2007 Jan;34(1):65-70
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  • BACKGROUND: Linear unilateral basal cell nevus represents a linear collection of macules and papules histologically similar to basal cell carcinoma but with benign clinical behavior.
  • The differential diagnosis included the nevoid basal cell carcinoma syndrome.
  • [MeSH-major] Nevus / genetics. Nevus / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Thigh
  • [MeSH-minor] DNA, Neoplasm. Diagnosis, Differential. Humans. Infant. Loss of Heterozygosity. Microsatellite Repeats. Mutation. Receptors, Cell Surface / genetics. Receptors, G-Protein-Coupled / genetics

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  • (PMID = 17214858.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Receptors, Cell Surface; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human; 0 / patched receptors
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19. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • We report 7 patients with sebaceous tumors in which neoplastic cells were arranged in a trabecular and ribbon-like pattern or formed rosettes/pseudorosettes.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Although the neoplasm appeared benign architecturally, the presence of cytologic atypia qualified 2 tumors as low-grade carcinomas.
  • We conclude that the carcinoid-like pattern is another distinctive pattern indicative of sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Schwartz RA, Rothenberg J: Metastatic adenocarcinoma of breast within a benign melanocytic nevus in the context of cutaneous breast metastatic disease. J Cutan Pathol; 2010 Dec;37(12):1251-4
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  • [Title] Metastatic adenocarcinoma of breast within a benign melanocytic nevus in the context of cutaneous breast metastatic disease.
  • Metastatic breast cancer of skin may be seen in a number of forms.
  • It is rare to find it in association with a benign melanocytic nevus.
  • We describe a patient with metastatic adenocarcinoma of breast within a benign melanocytic nevus and delineate this occurrence within the context of reviewing cutaneous breast metastatic disease.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Metastasis

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 20002237.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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21. Busam KJ: Cutaneous desmoplastic melanoma. Adv Anat Pathol; 2005 Mar;12(2):92-102
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  • [Title] Cutaneous desmoplastic melanoma.
  • It most often presents as an indurated lesion in chronically sun-damaged skin.
  • At the time of excision, the tumors usually extend into the reticular dermis or deeper.
  • It may simulate histologically sclerosing melanocytic nevi as well as various benign and malignant nonmelanocytic lesions.
  • There is significant morphologic variability among tumors classified as DM.
  • Desmoplasia may be prominent throughout the entire tumor ("pure" DM) or represent a portion of an otherwise nondesmoplastic melanoma ("combined" DM).
  • Some tumors show neuroma-like features with prominent nerve involvement, in which case the term "desmoplastic neurotropic melanoma" is used.
  • Evidence is also emerging that for patients with thick melanomas, the presence of a paucicellular fibrosing tumor histology (pure DM) is a favorable prognostic factor for survival.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Fibrosis. Humans. Neoplasm Recurrence, Local. Nevus, Pigmented / diagnosis. S100 Proteins / analysis. Sunlight / adverse effects

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  • (PMID = 15731577.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
  • [Number-of-references] 56
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22. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • In this paper case of 16-years-old male patient with many solid tumors in subcutaneous tissue on both arms will be reported.
  • The first skin lesion appeared on the left arm 6 years ago.
  • Histopathological test has proved the clinical diagnosis of pilomatrixoma.
  • [MeSH-major] Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Cicatrix / diagnosis. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Inflammation. Male. Treatment Outcome

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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23. Repertinger S, Wang J, Adickes E, Sarma DP: Melanoma in-situ arising in seborrheic keratosis: a case report. Cases J; 2008;1(1):263
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  • BACKGROUND: Seborrheic keratosis is a very common benign skin tumor in man.
  • Melanoma is rare but is the most dreaded of all malignant skin tumors.
  • CASE PRESENTATION: An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion.

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  • [Cites] Australas J Dermatol. 2006 May;47(2):109-13 [16637806.001]
  • [Cites] J Am Acad Dermatol. 2000 May;42(5 Pt 1):831-3 [10775864.001]
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  • (PMID = 18947402.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2577645
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24. Machet L, Nemeth-Normand F, Giraudeau B, Perrinaud A, Tiguemounine J, Ayoub J, Alison D, Vaillant L, Lorette G: Is ultrasound lymph node examination superior to clinical examination in melanoma follow-up? A monocentre cohort study of 373 patients. Br J Dermatol; 2005 Jan;152(1):66-70
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  • Mean age at diagnosis of melanoma was 59 years (range 14-90, SD 15).
  • Despite this apparent superiority of ultrasound examination over palpation, only 7.2% of the patients really benefited from ultrasound examination (earlier lymph node metastasis detection or avoidance of unnecessary surgery), while 5.9% had some deleterious effect from ultrasound examination (unnecessary stress caused by repetition of ultrasound examination for benign lymph nodes, useless removal of benign lymph node).
  • CONCLUSIONS: This study confirms the greater sensitivity of ultrasound examination to clinical examination in the diagnosis of node metastases from cutaneous melanoma.
  • [MeSH-major] Lymphatic Metastasis / ultrasonography. Melanoma / secondary. Melanoma / ultrasonography. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Long-Term Care / methods. Male. Middle Aged. Neoplasm Staging. Palpation. Physical Examination. Practice Guidelines as Topic. Sensitivity and Specificity

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  • (PMID = 15656802.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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25. Idan A, Griffiths KA, Harwood DT, Seibel MJ, Turner L, Conway AJ, Handelsman DJ: Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial. Ann Intern Med; 2010 Nov 16;153(10):621-32
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  • BACKGROUND: Benign prostatic hypertrophy increases with age and can result in substantially decreased quality of life for older men.
  • [MeSH-minor] Administration, Cutaneous. Antigens, Neoplasm / blood. Body Composition / drug effects. Bone Density / drug effects. Collagen Type I / blood. Double-Blind Method. Estradiol / blood. Fetal Proteins. Gels. Humans. Luteinizing Hormone / blood. Male. Middle Aged. Peptide Fragments. Procollagen. Prostate-Specific Antigen / blood. Prostatic Hyperplasia / prevention & control. Testosterone / blood

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  • [CommentIn] Ann Intern Med. 2010 Nov 16;153(10):678-9 [21079226.001]
  • [CommentIn] Praxis (Bern 1994). 2011 Mar 2;100(5):319-20 [21365566.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2010 Nov 16;153(10):I38 [21079202.001]
  • (PMID = 21079217.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Antigens, Neoplasm; 0 / Collagen Type I; 0 / Fetal Proteins; 0 / Gels; 0 / Peptide Fragments; 0 / Procollagen; 0 / procollagen Type I N-terminal peptide; 08J2K08A3Y / Dihydrotestosterone; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol; 9002-67-9 / Luteinizing Hormone; EC 3.4.21.77 / Prostate-Specific Antigen
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26. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31
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  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • PEComa is a rare, recently described, family of tumors with diverse clinicopathologic expression and which express melanocytic and muscle markers.
  • It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin.
  • To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-major] Cheek / pathology. Facial Neoplasms / diagnosis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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27. Matsuo Y, Kamitani T: Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma. PLoS One; 2010;5(5):e10481
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  • BACKGROUND: Melanoma is the major cause of skin cancer death worldwide.
  • Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes.
  • METHODOLOGY/PRINCIPAL FINDINGS: Recently, we found that human melanoma cell lines highly express alpha-synuclein, whereas the protein is undetectable in the non-melanoma cancer cell lines tested.
  • To investigate the expression of alpha-synuclein in human melanoma tissues, we immunostained sections of melanoma, nevus, non-melanocytic cutaneous carcinoma, and normal skin. alpha-Synuclein was positively detected in 86% of the primary and 85% of the metastatic melanoma sections, as well as in 89% of nevus sections.
  • However, alpha-synuclein was undetectable in non-melanocytic cutaneous carcinoma and normal skin.
  • CONCLUSIONS/SIGNIFICANCE: The Parkinson's disease-related protein, alpha-synuclein, is expressed in both malignant and benign melanocytic lesions, such as melanomas and nevi.
  • Although alpha-synuclein cannot be used to distinguish between malignant and benign melanocytic skin lesions, it might be a useful biomarker for the diagnosis of metastatic melanoma.
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Cell Line, Tumor. Female. Humans. MART-1 Antigen. Male. Melanins / metabolism. Middle Aged. Neoplasm Proteins / metabolism. Nevus / metabolism. Nevus / pathology. Pigmentation. Retinoblastoma / metabolism. Retinoblastoma / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 20463956.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG024497
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanins; 0 / Neoplasm Proteins; 0 / alpha-Synuclein
  • [Other-IDs] NLM/ PMC2864738
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28. Glaich AS, Behroozan DS, Cohen JL, Goldberg LH: Lymphoepithelioma-like carcinoma of the skin: a report of two cases treated with complete microscopic margin control and review of the literature. Dermatol Surg; 2006 Feb;32(2):316-9
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  • [Title] Lymphoepithelioma-like carcinoma of the skin: a report of two cases treated with complete microscopic margin control and review of the literature.
  • Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm with microscopic similarities to non-cutaneous lymphoepitheliomatous malignancies, particularly undifferentiated carcinoma of the nasopharynx.
  • It can be clinically and histologically confused with other benign and malignant tumors.
  • [MeSH-major] Carcinoma / surgery. Skin Neoplasms / surgery

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  • (PMID = 16442062.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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29. Sapp M, Bienkowska-Haba M: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus. FEBS J; 2009 Dec;276(24):7206-16
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  • Papillomaviruses are epitheliotropic non-enveloped double-stranded DNA viruses, whose replication is strictly dependent on the terminally differentiating tissue of the epidermis.
  • They induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carcinoma).

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  • (PMID = 19878308.001).
  • [ISSN] 1742-4658
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI081809-01A1; United States / NIAID NIH HHS / AI / R01 AI081809; United States / NCRR NIH HHS / RR / P20 RR018724; United States / NCRR NIH HHS / RR / P20-RR018724; United States / NIAID NIH HHS / AI / AI081809-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Capsid Proteins; 0 / HPV L1 protein, Human papillomavirus; 0 / Heparan Sulfate Proteoglycans; 0 / Oncogene Proteins, Viral
  • [Number-of-references] 80
  • [Other-IDs] NLM/ NIHMS160680; NLM/ PMC2795018
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30. Naik V, Arsenovic N, Reed M: Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma. Dermatol Online J; 2009;15(9):6
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  • Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous tumor characterized by proliferation of the eccrine gland elements closely associated with capillary angiomatosis and proliferation of other dermal elements, such as adipose tissue, hair and epidermis.
  • Clinically, this condition must be differentiated from other angiomatoses and a definitive diagnosis is based upon histology.
  • Eccrine angiomatous hamartoma is a benign slowly growing lesion for which aggressive treatment is not indicated.
  • [MeSH-major] Eccrine Glands / pathology. Hamartoma / diagnosis. Sweat Gland Diseases / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Friction. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Nevus, Blue / diagnosis. Skin / injuries. Skin Neoplasms / diagnosis

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  • (PMID = 19930993.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Blomberg M, Jeppesen EM, Skovby F, Benfeldt E: FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature. Dermatology; 2010;220(4):297-305
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  • [Title] FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature.
  • Somatic FGFR3 mutations have been found in malignant neoplasms and more recently in several cutaneous elements.
  • In the recent literature, an increasing number of different cutaneous elements have been found to harbor mutations of FGFR3, suggesting that FGFR3 plays a role in the pathogenesis of these elements.
  • We review the present literature, describing studies in which FGFR3 mutations have been investigated in skin lesions: primarily seborrheic keratoses and epidermal nevi, but also other benign skin tumors and a single case of a squamous cell carcinoma.
  • In addition, an overview of the FGFR3 point mutations in relation to each cutaneous element is given.
  • Based on the current knowledge, it seems likely that these cutaneous lesions have a common genetic background.

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20453470.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 12629-01-5 / Human Growth Hormone; 33515-09-2 / Gonadotropin-Releasing Hormone; 9100L32L2N / Metformin; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Number-of-references] 54
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32. Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N: Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res; 2010 Nov 15;70(22):9381-90
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  • [Title] Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
  • Notably, we found the DKO mice to be extremely susceptible to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin carcinogenesis that involves oncogenic mutation of the H-ras gene.
  • Mechanistic investigations suggested that the high incidence of cancer in DKO mice likely reflected a cooperative effect of increased benign skin tumor formation caused by p21Waf1/Cip1 loss, with increased malignant conversion of benign skin tumors caused by p16(INK4a) loss.
  • Our findings establish an intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
  • [MeSH-major] Cell Aging. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Skin Neoplasms / metabolism

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  • [Copyright] Copyright © 2010 AACR.
  • (PMID = 21062974.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / H2AX protein, mouse; 0 / Histones; 0 / Octamer Transcription Factor-3; 0 / Pou5f1 protein, mouse; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 3.6.5.2 / ras Proteins; NI40JAQ945 / Tetradecanoylphorbol Acetate
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33. Wu Y, Zhang XB, Liu HJ, Zheng LD, Li JW, Lin Y: [Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Jul;36(7):466-9
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  • [Title] [Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma].
  • METHODS: Immunohistochemical study for CD10 and CD9 using Streptavidin-biotin complex technique was carried out in 48 cases of primary cutaneous malignant melanoma (CMM), 23 cases of metastatic melanoma and 23 cases of benign nevus.
  • RESULTS: The positivity rate of CD10 was highest in metastatic melanoma and lowest in benign nevus (P < 0.01).
  • The expression of CD10 and CD9 in CMM also correlated with tumor histology, Clark's level of invasion and presence of nodal metastasis.
  • [MeSH-major] Antigens, CD / metabolism. Melanoma / metabolism. Melanoma / pathology. Membrane Glycoproteins / metabolism. Neprilysin / metabolism. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD9. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 17845760.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; EC 3.4.24.11 / Neprilysin
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34. Golod O, Soriano T, Craft N: Palisaded encapsulated neuroma--a classic presentation of a commonly misdiagnosed neural tumor. J Drugs Dermatol; 2005 Jan-Feb;4(1):92-4
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  • [Title] Palisaded encapsulated neuroma--a classic presentation of a commonly misdiagnosed neural tumor.
  • We present a case report of a classical presentation of palisaded encapsulated neuroma (PEN) of the skin occurring on the nasolabial crease and a review of the literature.
  • Histologic examination revealed a well-circumscribed dermal nodule of small spindle cells with wavy nuclei arranged in fascicles, consistent with the diagnosis of PEN.
  • PEN is a previously described, benign cutaneous neural tumour, with a histological appearance between that of a neurofibroma and a schwannoma.
  • [MeSH-major] Neuroma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasm Proteins / metabolism

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  • (PMID = 15696992.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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35. Schad K, Baumann Conzett K, Cozzio A: [Cutaneous lymphomas]. Ther Umsch; 2010 Sep;67(9):453-64
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  • [Title] [Cutaneous lymphomas].
  • Cutaneous lymphomas are a heterogenous group of lymphoproliferative disorders of the T- and B-lymphocytes with a low incidence of approximately 1:100000/year.
  • They belong to the Non-Hodgkin lymphoma.
  • The skin is the second most abundant site of extranodal lymphoma formation (after the GI tract).
  • The new WHO/EORTC classification of cutaneous T- and B-cell lymphomas provides a widely accepted nomenclature for primary cutaneous lymphomas based primarily on clinical, but also on histologic, cytologic and molecular features.
  • The clear distinction of primary cutaneous from secondary cutaneous lymphoma will also be important to prevent overtreatment of the frequently benign primary cutaneous lymphoma.
  • Treatment of primary cutaneous lymphoma is skin-directed in early disease stages, and uses as systemic approach in advanced stages.
  • Skin-directed therapies encompass UV-light treatment such as UVB311nm, or PUVA, topical steroids class III and IV, or bexaroten gel.
  • We recommend that advanced stages of cutaneous lymphoma should be treated in centers that offer clinical studies in this field, because prognosis of late stages is still dismal and there is so far no therapeutic approach that has led to an increase in overall survival.
  • Hence, inclusion of patients in prospective controlled clinical studies should always be considered in patients with primary cutaneous lymphoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymphoma, B-Cell / diagnosis. Lymphoma, T-Cell, Cutaneous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Interferon-alpha / therapeutic use. Mycosis Fungoides / diagnosis. Mycosis Fungoides / drug therapy. Mycosis Fungoides / pathology. Mycosis Fungoides / radiotherapy. Neoplasm Staging. PUVA Therapy. Prognosis. Radiotherapy, Adjuvant. Skin / pathology

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  • (PMID = 20806174.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha
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36. Khalil SH, Hamadah IR: The applicability of T-cell receptor gamma gene rearrangement as an adjuvant diagnostic tool in skin biopsies for cutaneous T-cell lymphoma. Saudi Med J; 2006 Jul;27(7):951-4
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  • [Title] The applicability of T-cell receptor gamma gene rearrangement as an adjuvant diagnostic tool in skin biopsies for cutaneous T-cell lymphoma.
  • OBJECTIVE: The diagnosis of cutaneous T-cell lymphoid infiltrates may be difficult based on clinical and routine immunohistologic findings.
  • In this situation, an ancillary technique demonstrating the presence of a monoclonal cell proliferation could help to rule in or out cutaneous T-cell lymphoma (CTCL) in cases that clinically and histopathologically do not allow a definitive diagnosis.
  • Southern blot analysis is a time-consuming method with low sensitivity that should not be considered for the routine diagnosis of cutaneous lymphoid infiltrates.
  • METHODS: We retrospectively studied 124 biopsies from 104 patients (66 biopsies with the clinical and histological diagnosis or suspicious of CTCL and 58 biopsies with histological diagnosis of benign reactive dermatological conditions who presented to the Dermatology Unit at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia between 1996 and 2004.
  • CONCLUSION: The detection of clonal TCR gamma gene rearrangement by PCR based method is an adjuvant diagnostic marker for CTCL, although it can be seen in some benign dermatoses.
  • [MeSH-major] Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics. Lymphoma, T-Cell, Cutaneous / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Biopsy. DNA, Neoplasm / analysis. Humans. Polymerase Chain Reaction / methods. Retrospective Studies. Saudi Arabia / epidemiology. Sensitivity and Specificity. Skin / pathology

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  • (PMID = 16830010.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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37. MacKie RM, Hauschild A, Eggermont AM: Epidemiology of invasive cutaneous melanoma. Ann Oncol; 2009 Aug;20 Suppl 6:vi1-7
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  • [Title] Epidemiology of invasive cutaneous melanoma.
  • Phenotypic markers of high-risk subjects include high counts of benign melanocytic naevi.
  • Other risk factors considered include exposure to natural and artificial ultraviolet radiation, the effect of female sex hormones, socioeconomic status, occupation, exposure to pesticides and ingestion of therapeutic drugs including immunosuppressives and non-steroidal anti-inflammatory drugs.
  • Aids to earlier diagnosis are considered, including public education, screening and use of equipment such as the dermatoscope.

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  • (PMID = 19617292.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
  • [Other-IDs] NLM/ PMC2712590
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38. Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R: A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution. Am J Dermatopathol; 2009 Feb;31(1):37-43
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  • [Title] A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution.
  • In 2 patients, the lesions spontaneously regressed within a few months after initial diagnosis.
  • In the majority of these cases, the lesions started showing evidence of clinical spontaneous regression and even complete resolution within a few months of initial diagnosis.
  • Because most of these cases follow a relatively benign clinical course, we recommend a more conservative approach in the clinical management of these patients.
  • [MeSH-major] Antigens, CD30 / metabolism. Lymphoma, Large-Cell, Anaplastic / complications. Lymphoma, Large-Cell, Anaplastic / pathology. Skin Diseases / complications. Skin Diseases / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hyperplasia. Male. Middle Aged. Neoplasm Regression, Spontaneous

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  • (PMID = 19155723.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30
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39. Cohn ML, Goncharuk VN, Diwan AH, Zhang PS, Shen SS, Prieto VG: Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms. J Cutan Pathol; 2005 Sep;32(8):533-6
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  • [Title] Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms.
  • Recent studies have suggested that some metastatic solid tumors lack claudin expression.
  • It is unknown whether claudins play a role in cutaneous melanoma.
  • Immunohistochemical studies were performed on tissue microarrays containing 19 benign melanocytic nevi (BN), 21 dysplastic nevi (DN), 23 primary malignant melanomas (MMs), and 31 metastatic melanomas (MMMs) using a polyclonal anti-claudin-1 antibody.
  • Immunoreactivity in tumor cells and associated vessels was graded by intensity and by percentage of reactive cells.
  • Tumor-associated vessels showed the following results: 11 of 19 (58%) in BN, 14 of 21 (67%) in DN, 17 of 23 (74%) in MM, and 6 of 31 (19%) in MMM.
  • A significant loss of expression was noted between MMM and all other lesions in tumor cells and associated vessels.
  • Within primary melanomas, there was a significant correlation between expression of claudin in tumor cells and Clark level/Breslow thickness.
  • Also significant was a decreased expression of claudin in tumor vessels of lesions with higher Breslow thickness or Clark level.
  • These data suggest that loss of claudin-1 may play a significant role in the acquisition of metastatic phenotype in cutaneous melanoma.
  • Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms.
  • [MeSH-major] Dysplastic Nevus Syndrome / metabolism. Melanoma / metabolism. Membrane Proteins / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Blood Vessels / metabolism. Blood Vessels / pathology. Claudin-1. Endothelium, Vascular / metabolism. Endothelium, Vascular / pathology. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Neoplasm Metastasis. Phenotype. Protein Array Analysis

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  • (PMID = 16115050.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins
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40. Sztramska A, Dymerska D, Chwirot BW: Skin layer-specific Melan-A expression during progression of human cutaneous melanoma: implications for diagnostic applications of the marker. Melanoma Res; 2008 Aug;18(4):259-67
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  • [Title] Skin layer-specific Melan-A expression during progression of human cutaneous melanoma: implications for diagnostic applications of the marker.
  • We have performed objective immunohistochemical assessment of the expression of Melan-A in benign naevi and melanomas at different stages of progression.
  • Our results show a complex pattern of changes in the expression of Melan-A in melanomas depending on the location of melanoma cells within individual skin layers.
  • The expression of the antigen during tumour progression significantly decreases for melanoma cells located in the granular/spinous layer (r=-0.94, P=0.02) and increases for the papillary layer (r=0.99, P=0.002) and reticular layer (r=0.89, P=0.04).
  • It should also be emphasized that from the Clark II level of progression the melanomas can be detected with high sensitivity and specificity using a simple cut-off test based on the determination of Melan-A expression in tumour cells located within the papillary layer.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Melanoma / diagnosis. Neoplasm Proteins / metabolism. Skin / metabolism. Skin Neoplasms / diagnosis

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  • (PMID = 18626310.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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41. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. Neurosurgery; 2006 Jul;59(1):E206; discussion E206
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  • [Title] Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report.
  • OBJECTIVE: The majority of tumors of the cerebellopontine angle (CPA) are benign.
  • We discuss the differential diagnosis and prognosis of melanotic lesions at this location.
  • A neurological work-up revealed a large tumor in the left CPA radiographically diagnosed as a vestibular schwannoma.
  • INTERVENTION: A translabyrinthine approach revealed a pigmented, vascular neoplasm encasing vessels and cranial nerves of the left CPA.
  • The tumor was subtotally resected, and a histopathological diagnosis of melanoma was made.
  • The patient had no history of cutaneous melanoma and no other site of disease was ever discovered.
  • The differential diagnosis of melanotic lesions of the CPA is discussed as are the prognostic implications of each diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / diagnosis. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Radiotherapy, Adjuvant. Tomography, X-Ray Computed


42. Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS: Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi. Ophthalmology; 2007 Apr;114(4):774-9
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  • [Title] Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.
  • PURPOSE: To evaluate a kindred with familial uveal and cutaneous melanoma and to identify potential genetic and environmental factors that may predispose individuals to develop uveal melanoma.
  • METHODS: Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds.
  • MAIN OUTCOME MEASURES: Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma.
  • RESULTS: The proband and his mother had uveal melanoma, 3 cutaneous melanomas occurred among 2 siblings, and 2 other siblings had basal cell carcinomas.
  • No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF.
  • Seven out of 10 siblings had a history of cutaneous and/or ocular nevi.
  • Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma).
  • Six were also found to be in the "high-risk" classification for cutaneous malignancies based on scores from a previously validated risk assessment tool.
  • CONCLUSIONS: Our results strengthen the association between uveal melanoma, atypical nevi, and cutaneous melanoma.
  • This relationship supports the recommendation that individuals with a personal or family history of uveal melanoma, particularly in combination with atypical nevi, should be regularly screened for uveal and cutaneous melanoma.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Pedigree. Risk Factors. Sequence Analysis, DNA. Surveys and Questionnaires. Tumor Suppressor Protein p14ARF / genetics


43. Pires I, Queiroga FL, Alves A, Silva F, Lopes C: Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. Anticancer Res; 2009 Jul;29(7):2713-7
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  • [Title] Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.
  • BACKGROUND: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression.
  • MATERIALS AND METHODS: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression.
  • CONCLUSION: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.
  • The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression.
  • [MeSH-major] Cadherins / metabolism. Histiocytoma, Benign Fibrous / veterinary. Neoplasm Regression, Spontaneous

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  • (PMID = 19596951.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cadherins
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44. Ausmus GG, Piliang MP, Bergfeld WF, Goldblum JR: Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature. J Cutan Pathol; 2007 Sep;34(9):726-30
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  • BACKGROUND: Perineurioma is a rare benign soft-tissue tumor composed of cells showing differentiation toward the perineurial cells of the nerve sheath.
  • Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF.
  • RESULTS: Histopathologic examination revealed a 2.0-cm well-circumscribed, spindle-cell neoplasm with slender, elongated, bipolar, wavy cytoplasmic processes and wavy, elongated nuclei in a hyalinized stroma with focal myxoid areas.
  • Perineuriomas can be confused with other spindle-cell neoplasms, and relevant features and immunohistochemistry of these lesions are outlined.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Mucin-1 / metabolism. Thorax. Tomography, X-Ray Computed. Treatment Outcome


45. Cross NJ, Fung DE: Tuberous sclerosis: a case report. Spec Care Dentist; 2010 Jul-Aug;30(4):157-9
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  • Tuberous sclerosis is an inherited neurocutaneous disorder that occurs in approximately 1 in 7,500 live births.
  • It is characterized by benign neoplasms of the skin, heart, kidneys, lungs, central nervous system, and mucosa.
  • Histologically, the appearance was described as nonspecific, but was consistent with a diagnosis of tuberous sclerosis.
  • [MeSH-major] Gingival Diseases / diagnosis. Tuberous Sclerosis / diagnosis
  • [MeSH-minor] Biopsy. Child. Dental Care for Disabled. Dental Caries / diagnosis. Female. Humans. Incisor / abnormalities

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  • (PMID = 20618782.001).
  • [ISSN] 1754-4505
  • [Journal-full-title] Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
  • [ISO-abbreviation] Spec Care Dentist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Soldano AC, Meehan SA: Cutaneous solitary fibrous tumor: a report of 2 cases and review of the literature. Am J Dermatopathol; 2008 Feb;30(1):54-8
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  • [Title] Cutaneous solitary fibrous tumor: a report of 2 cases and review of the literature.
  • Solitary fibrous tumor is an uncommon mesenchymal neoplasm that can arise in both pleural and extrapleural locations.
  • Composed of spindled cells intimately admixed with collagen bundles arranged in a "patternless pattern," this heterogeneous tumor can mimic a variety of benign and malignant mesenchymal neoplasms.
  • We present the histological and immunohistochemical findings of two primary cutaneous solitary fibrous tumors, discuss the differential diagnosis, and review the literature.
  • Although solitary fibrous tumors in cutaneous and subcutaneous regions are extremely rare, it should be considered in the differential diagnosis of primary spindle cell neoplasms of the skin.
  • [MeSH-major] Skin Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18212546.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Stadler R: Optimal combination with PUVA: rationale and clinical trial update. Oncology (Williston Park); 2007 Feb;21(2 Suppl 1):29-32
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  • Cutaneous T-cell lymphoma (CTCL) is relatively benign in its early stages, but survival rates decrease dramatically as the disease progresses.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymphoma, T-Cell, Cutaneous / drug therapy. PUVA Therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Clinical Trials as Topic. Combined Modality Therapy. Diphtheria Toxin / therapeutic use. Disease Progression. Doxorubicin / therapeutic use. Humans. Immunologic Factors / therapeutic use. Interferon-alpha / therapeutic use. Interleukin-2 / therapeutic use. Neoplasm Staging. Photopheresis. Recombinant Fusion Proteins / therapeutic use. Retinoids / therapeutic use. Tetrahydronaphthalenes / therapeutic use

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  • (PMID = 17474357.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Diphtheria Toxin; 0 / Immunologic Factors; 0 / Interferon-alpha; 0 / Interleukin-2; 0 / Recombinant Fusion Proteins; 0 / Retinoids; 0 / Tetrahydronaphthalenes; 25E79B5CTM / denileukin diftitox; 80168379AG / Doxorubicin; A61RXM4375 / bexarotene
  • [Number-of-references] 26
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48. Zhang Q, Wang WH, Zhao M, Shen L, Cheng JH, Zhang BY, Li LF: Clinical and pathological study of lichen-planus-like keratosis in China. J Dermatol; 2006 Jul;33(7):457-61
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  • Lichen-planus-like keratosis is usually diagnosed pathologically; rarely, a definitive diagnosis can be made grossly in the clinic.
  • Lichen-planus-like keratosis is not uncommon in clinical practice in China, the diagnosis of lichen-planus-like keratosis should be made by a combination of clinical manifestations and pathological changes.
  • It is better to classify lichen-planus-like keratosis as a benign skin tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. China / epidemiology. Diagnosis, Differential. Female. Humans. Lichen Planus / diagnosis. Male. Middle Aged

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  • (PMID = 16848817.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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49. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • The tumors arose most often on the upper limb (35%) or head and neck (33%).
  • Fifty-two percent of the tumors were limited to the dermis, and 48% also involved superficial subcutaneous tissue.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Nearly all tumors had a lobulated or micronodular architecture and were composed of nests and bundles of epithelioid to spindled cells with palely eosinophilic cytoplasm, often separated by dense hyaline collagen; 17 (13%) showed focally sheetlike areas, and 5 (4%) were notably plexiform.
  • Myxoid stroma was observed in 38 (29%) tumors; 11 (8%) were predominantly myxoid.
  • Most tumors showed mild cytologic atypia in the form of nuclear variability and small nucleoli; 33 (25%) contained notably pleomorphic cells.
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • All tumors were negative for S-100 protein.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-major] Neurothekeoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. Hügel H: [Fibrohistiocytic skin tumors]. J Dtsch Dermatol Ges; 2006 Jul;4(7):544-55
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  • [Title] [Fibrohistiocytic skin tumors].
  • [Transliterated title] Fibrohistiozytäre Tumoren der Haut.
  • The fibrohistiocytic tumors of the skin are a heterogeneous group of dermal/subcutaneous mesenchymal neoplasms which show fibroblastic, myofibroblastic and histiocytic (macrophage-like) differentiation, often one beside the other in the same tumor.
  • The WHO classification of 2005 includes the following entities as fibrohistiocytic tumors of the skin: BENIGN: 1.
  • INTERMEDIATE: 4. plexiform fibrohistiocytic tumor; 5. dermatofibrosarcoma protuberans; 6. atypical Fibroxanthoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / classification. Histiocytoma, Benign Fibrous / pathology. Leiomyoma / classification. Leiomyoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Histiocytic Disorders, Malignant / classification. Histiocytic Disorders, Malignant / pathology. Humans

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  • (PMID = 16827912.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
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51. Wright NA, Thomas CG, Calame A, Cockerell CJ: Granular cell atypical fibroxanthoma: case report and review of the literature. J Cutan Pathol; 2010 Mar;37(3):380-5
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  • The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man.
  • The granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors.
  • We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor. Disease-Free Survival. Humans. Immunohistochemistry. Male. Scalp / metabolism. Scalp / pathology. Scalp / surgery. Treatment Outcome

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  • (PMID = 19341433.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • Only one case of sporadic TB in a composite tumor has been reported, arising in an apocrine poroma.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • It was often positive in the associated neoplasm.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • TB can be added to the spectrum of SK-associated tumors.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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53. Sugano DM, Lucci LM, Avila MP, Rehder JR, Pettinati J: [Eyelid trichoepithelioma--report of 2 cases]. Arq Bras Oftalmol; 2005 Jan-Feb;68(1):136-9
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  • [Transliterated title] Tricoepitelioma palpebral--relato de 2 casos.
  • Trichoepithelioma is a benign skin tumor and is most commonly found on the face, however, there are few reports about its occurrence on the eyelids.
  • [MeSH-major] Eyelid Neoplasms / pathology. Neoplasms, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 15824820.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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54. Roche NA, Monstrey SJ, Matton GE: Pilomatricoma in children: common but often misdiagnosed. Acta Chir Belg; 2010 Mar-Apr;110(2):250-4
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  • A pilomatricoma, also known as pilomatrixoma or calcifying epithelioma of Malherbe, is a benign skin tumor arising from the hair follicle matrix.
  • This tumor is common in children and young adults, especially in the head and neck region.
  • The history is typical of a slowly enlarging mass, irregularly contoured, it is fixed to the skin but slides freely over the, underlying tissues, often with a discolouration which varies from red to purple-bluish.
  • Ultrasound examination, MRI-scan and fine-needle aspiration can be helpful if the diagnosis is uncertain.
  • [MeSH-major] Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20514848.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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55. Káram-Orantes M, Fonte-Avalos V, Zuloaga-Salcedo S, Domínguez-Cherit J: [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006]. Gac Med Mex; 2007 Sep-Oct;143(5):371-5
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  • [Title] [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006].
  • [Transliterated title] Frecuencia de tumores benignos durante el periodo de 2000-2006 en el Hospital General "Dr. Manuel Gea González".
  • BACKGROUND: Benign skin neoplasms are defined as autonomous growing tissue unrelated to normal growing of the skin, that persist even after the originating stimulus dissapears.
  • Almost all human beings have a certain number of benign cutaneous neoplasms and many never seek medical attention.
  • There is a dearth of information regarding the frequency of these tumors.
  • The aim of this study was to record the number of benign tumors studied at the Dermatology Department of a medical facility.
  • We included year of admission, number of biopsies, sex, age, tumor location, histological and clinical diagnoses.
  • RESULTS: We analyzed 9,436 biopsies of which 3,765 constituted benign neoplasms; 595 were not included and our total sample was 3,170 tumors.
  • The most frequent tumors according to histopathological diagnoses in descending order were: melanocytic, cutaneous cysts, fibrous tumors, vascular tumors, epidermal tumors, fat tumors, tumors with hair differentiation, neural tumors, glandular tumors, tumors with sebaceous differentiation, cartilage and bone tumors, and smooth muscle tumors.
  • The most common benign tumors were: Melanocytic nevi, epidermal cysts, seborrheic keratoses, pyogenic granulomas, lipomas and dermatofibromas.
  • CONCLUSIONS: Melanocytes represented by melanocytic nevi (junctional, intradermic and compound) were the most frequent benign neoplasms, followed by epidermoid cysts.
  • Our results illustrate the most common benign tumors observed in a dermatology department.
  • [MeSH-major] Neoplasms / epidemiology

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  • (PMID = 18246930.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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56. El Safoury OS, Fawzy MM, El Maadawa ZM, Mohamed DH: Quantitation of mast cells and collagen fibers in skin tags. Indian J Dermatol; 2009;54(4):319-22
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  • [Title] Quantitation of mast cells and collagen fibers in skin tags.
  • BACKGROUND: Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people.
  • AIMS: The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags.
  • METHODS: Thirty participants with skin tags were divided into two groups (15 diabetic and 15 nondiabetic).
  • Three biopsies were obtained from one anatomical site: A large skin tag, a small skin tag, and adjacent normal skin.
  • RESULTS: A statistically significant correlation between mast cell count and percentage of collagen mean area was detected in both studied groups (except in large skin tags of the nondiabetic group).
  • CONCLUSION: The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts.

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  • [Cites] Eur J Histochem. 2006 Apr-Jun;50(2):133-40 [16864125.001]
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  • (PMID = 20101330.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2807705
  • [Keywords] NOTNLM ; Bismarck brown / Image analyzer / mast cells / mean collagen area % / skin tags
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57. Halliday GM, Lyons JG: Inflammatory doses of UV may not be necessary for skin carcinogenesis. Photochem Photobiol; 2008 Mar-Apr;84(2):272-83
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  • [Title] Inflammatory doses of UV may not be necessary for skin carcinogenesis.
  • The UV wavelengths in sunlight are the main cause of skin cancer in humans.
  • While it is clear that immunosuppression and gene mutations are essential biologic events via which UV causes skin cancer, the requirement for UV-induced inflammation is less certain.
  • Both the UVB (290-320 nm) and UVA (320-400 nm) wavebands within sunlight can cause skin cancer, gene mutations and immunosuppression.
  • However, UVB, but not UVA, at realistic doses can cause inflammation, and UVB induces skin cancer, immunosuppression and gene mutations at doses much lower than those required to cause inflammation.
  • Inflammation enhances skin carcinogenesis, but may not be UV induced, and inflammatory mediators at doses too low to cause inflammation may be required.
  • Our hypothesis is therefore that subinflammatory doses of both UVA and UVB cause benign skin tumors.
  • [MeSH-major] Neoplasms, Radiation-Induced / etiology. Skin Neoplasms / etiology. Ultraviolet Rays

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  • (PMID = 18353168.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 152
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58. Finn LS, Argenyi ZB: Congenital panfollicular nevus: report of a new entity. J Cutan Pathol; 2005 Jan;32(1):59-62
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  • The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units.
  • We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives.
  • This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.
  • [MeSH-major] Hair Diseases / congenital. Hamartoma / congenital. Nevus / congenital. Skin Neoplasms / congenital


59. Krejsgaard T, Vetter-Kauczok CS, Woetmann A, Kneitz H, Eriksen KW, Lovato P, Zhang Q, Wasik MA, Geisler C, Ralfkiaer E, Becker JC, Ødum N: Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma. Blood; 2009 Jun 4;113(23):5896-904
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  • [Title] Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma.
  • Here, we demonstrate nuclear factor-kappa B (NF-kappaB)-mediated ectopic expression of Blk in malignant T-cell lines established from patients with cutaneous T-cell lymphoma (CTCL).
  • Already in early disease the majority of epidermotropic T cells express Blk, whereas Blk expression is not observed in patients with benign inflammatory skin disorders.
  • In a longitudinal study of an additional 24 patients biopsied for suspected CTCL, Blk expression significantly correlated with a subsequently confirmed diagnosis of CTCL.

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  • (PMID = 19351960.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA089194; United States / NCI NIH HHS / CA / CA89194
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; EC 2.7.1.- / protein-tyrosine kinase p55(blk); EC 2.7.10.2 / src-Family Kinases
  • [Other-IDs] NLM/ PMC2700325
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60. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Title] Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • The ACC-like areas were a minor but significant component in all lesions and were usually multifocal and blended with the conventionally appearing parts of the neoplasms.
  • In some neoplasms, only mucin occurred in these pseudoglandular structures, whereas in other cases, a combination of all 3 secretory products was encountered.
  • Although well-developed bilayered glands with a demonstrable peripheral myoepithelial cell layer were not recognizable in the ACC-like areas, immunohistochemistry demonstrated myoepithelial differentiation in these portions of the tumors.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Syndrome

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Requena L, Luis Díaz J, Manzarbeitia F, Carrillo R, Fernández-Herrera J, Kutzner H: Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. J Cutan Pathol; 2008 Feb;35(2):225-30
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  • [Title] Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases.
  • The term hemangioendothelioma has been used in recent years to name a heterogeneous group of vascular neoplasms, intermediate in both biological behavior and histopathologic appearance between benign tumors (hemangiomas) and frankly malignant tumors (angiosarcomas).
  • The latter is a vascular neoplasm showing varying combinations of benign, low-grade malignant and malignant vascular components.
  • The neoplasm showed a more aggressive behavior than other reported cases of composite hemangioendothelioma and it developed satellitosis and metastases to the inguinal lymph nodes.
  • [MeSH-major] Foot Diseases / pathology. Hemangioendothelioma / pathology. Leg / pathology. Lymphatic Metastasis / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18190450.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein
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62. Chaby G, Viseux V, Chatelain D, Denoeux JP, Lok C: [Myxofibrosarcoma associated with anetoderma]. Ann Dermatol Venereol; 2006 Jan;133(1):35-7
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  • BACKGROUND: Association of malignant cutaneous tumor and secondary anetoderma is rare.
  • One year later, she developed a recurrent tumor at the same site, with similar clinical presentation, which was treated by broad excision.
  • DISCUSSION: Secondary anetoderma is usually seen in association with cutaneous infections and benign skin tumors.
  • Myxofibrosarcoma (formerly referred to as myxoid malignant fibrous histiocytoma) is characterized by an abundant myxoid background in at least one half of the tumor.
  • The tumor recurs in almost two-thirds of cases and metastasizes in one-fourth.
  • Our case confirms that a unique, acquired anetodermic lesion can reveal a malignant tumor.
  • [MeSH-major] Fibrosarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16495849.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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63. Fernandez-Flores A, Manjon JA: Mitosis in dermatofibroma: a worrisome histopathologic sign that does not necessarily equal recurrence. J Cutan Pathol; 2008 Sep;35(9):839-42
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  • BACKGROUND: High mitotic rate is a worrying histopathologic feature that pathologists occasionally face when diagnosing benign fibrous histiocytoma (BFH), that otherwise seem to be benign.
  • CONCLUSIONS: We conclude that common BFH can occasionally present a high mitotic rate and still show a benign behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mitosis. Neoplasm Recurrence, Local. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antibodies, Antinuclear / immunology. Antibodies, Monoclonal / immunology. Biomarkers, Tumor / metabolism. Biopsy. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged

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  • (PMID = 18331566.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MIB-1 antibody
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64. Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J; 2010 Jan 6;29(1):131-44
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  • CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis.
  • [MeSH-major] Cell Cycle / physiology. Histone Deacetylases / metabolism. Tubulin / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Acetylation. Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Catalytic Domain. Cell Line, Tumor. Cytokinesis. Genes, Tumor Suppressor. Humans. Keratinocytes / cytology. Keratinocytes / drug effects. Keratinocytes / metabolism. Melanocytes / cytology. Melanocytes / drug effects. Melanocytes / metabolism. Melanoma / genetics. Melanoma / metabolism. Melanoma / pathology. Mice. Microtubules / metabolism. Mutation. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. Skin Neoplasms / genetics. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology


65. Dorić M, Radović S, Kuskunović S, Hukić A, Babić M, Tomić I, Selak I: Dermal squamomelano-cytic tumor: neoplasm of uncertain biological potential. Bosn J Basic Med Sci; 2008 May;8(2):152-5
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  • [Title] Dermal squamomelano-cytic tumor: neoplasm of uncertain biological potential.
  • We report a case of exceedingly rare cutaneous neoplasm with histological features of malignancy and uncertain biological potential.
  • The nodular, darkly pigmented facial tumor with central exulceration, size 12 x 10 x 7 mm, of the skin 61-year-old man preauricular left was completely exised.
  • Histologically tumor consists of atypical squamous cells, which express signs of moderate to significant pleomorphism, mitotically active, with foci forming of parakeratotic horn cysts ("pearls").
  • Characteristically tumor also consists of large number of atypical melanocytes with multifocal pattern, inserted between atypical squamous cells, and which contain large amount of dark brown pigment melanin.
  • The follow-up time of four years no evidence of recurrence or metastasis, similar all reported cases, but it is too short period in estimation to guarantee a benign course.
  • However, it appears that this group of neoplasm may have different prognosis from pure squamous carcinoma or malignant melanoma.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Facial Neoplasms / diagnosis. Facial Neoplasms / pathology. Melanoma / diagnosis. Melanoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 18498266.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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66. Demirkan NC, Bir F, Erdem O, Düzcan E: Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors. J Cutan Pathol; 2007 Jun;34(6):467-73
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  • [Title] Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors.
  • The aim of this study was to determine the role of beta-catenin-related proteins in various benign trichogenic tumors.
  • METHODS: We investigated the expression of beta-catenin, E-cadherin, c-myc and cyclin D1 immunohistochemically, and the expression of these molecules were compared between two groups consisting of 12 PMXs and 12 other benign trichogenic tumors (OBTTs).
  • RESULTS: In PMX group, nuclear and/or cytoplasmic expression of beta-catenin was associated with a loss of membranous expression of E-cadherin (p = 0.002).
  • In OBTT group, a membranous expression of E-cadherin and beta-catenin was observed, and there was a stronger nuclear immunoreactivity of cyclin D1 compared with PMX group (p = 0.006).
  • [MeSH-major] Cadherins / metabolism. Cyclins / metabolism. Hair Diseases / metabolism. Pilomatrixoma / metabolism. Proto-Oncogene Proteins c-myc / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cyclin D. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism


67. Kannangara AP, Levitan D, Fleischer AB Jr: Six patients with early-stage cutaneous T-cell lymphoma successfully treated with topical 5-fluorouracil. J Drugs Dermatol; 2010 Aug;9(8):1017-8
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  • [Title] Six patients with early-stage cutaneous T-cell lymphoma successfully treated with topical 5-fluorouracil.
  • Topical 5-fluorouracil (5-FU) has been used in the treatment of various benign and malignant tumors of the skin, but only few address its therapeutic value on cutaneoues T-cell lymphoma. (CTCL).
  • Four patients achieved complete response (CR) and two patients responded partially (PR).
  • [MeSH-major] Fluorouracil / therapeutic use. Lymphoma, T-Cell, Cutaneous / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Adult. Aged. Aged, 80 and over. Antimetabolites, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / adverse effects. Antimetabolites, Antineoplastic / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 20684155.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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68. Pham TT, Selim MA, Burchette JL Jr, Madden J, Turner J, Herman C: CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol; 2006 Feb;33(2):123-8
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  • BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC).
  • However, it is important to distinguish these neoplasms.
  • Limited immunohistochemical stains are available to separate these two tumors.
  • Cases were analyzed for pattern of CD10 expression by tumor cells and surrounding stroma.
  • Thus, CD10 may be a useful adjunct marker in distinguishing these tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / metabolism. Neoplasms, Basal Cell / metabolism. Neprilysin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 16420307.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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69. Clarke LE, Seykora JT: Primary cutaneous adenomyoepithelioma. J Cutan Pathol; 2007 Aug;34(8):654-7
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  • [Title] Primary cutaneous adenomyoepithelioma.
  • An 83-year-old Caucasian woman presented to her dermatologist with a 5-cm subcutaneous tumor on her right thigh.
  • Incisional biopsy showed a multinodular tumor composed of variably sized glands comprised of a luminal layer of epithelial cells surrounded by one or more layers of myoepithelial cells.
  • The histopathologic features resembled those of adenomyoepithelioma, an uncommon neoplasm usually encountered within the breast.
  • Primary cutaneous adenomyoepithelioma is very rare yet shares histopathologic features with common cutaneous lesions such as spiradenomas and benign mixed tumors (chondroid syringomas).
  • Primary cutaneous adenomyoepithelioma is part of the spectrum of epithelial-myoepithelial tumors that includes benign mixed tumor, myoepithelioma and myoepithelial carcinoma.
  • This rare tumor may mimic malignant lesions including metastatic adenocarcinoma.
  • Like its breast counterpart, primary cutaneous adenomyoepithelioma should probably be regarded as a neoplasm of borderline malignant potential.
  • [MeSH-major] Adenomyoma / pathology. Myoepithelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17640238.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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70. de Prado Prieto L, García Olmos L, Rodríguez Salvanés F, Otero Puime A: [Evaluation of referrals in primary care]. Aten Primaria; 2005 Feb 28;35(3):146-51
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  • [Transliterated title] Evaluación de la demanda derivada en atención primaria.
  • The most common conditions referred, 25.6% of all referrals, are gynecologist check, blindness, other illnesses of subcutaneous cellular tissue, arthrosis, joint pain, diabetes, benign neoplasm of skin, depression and hypoacusis.

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  • (PMID = 15737271.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Spain
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71. Leboeuf NR, Mahalingam M: Acanthomatous superficial sebaceous hamartoma? A study of six cases with clarification of the nomenclature. J Cutan Pathol; 2007 Nov;34(11):865-70
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  • The nomenclature for benign tumors with foci of sebaceous differentiation is confusing and varied.
  • Furthermore, the unifying architecture of the cases presented supports maintenance of the original nomenclature of superficial epithelioma with sebaceous differentiation and indicates that this neoplasm is perhaps not as rare as currently believed.
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Keratosis, Seborrheic / pathology. Male. Middle Aged

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  • (PMID = 17944728.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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72. McHugh JB, Fullen DR, Ma L, Kleer CG, Su LD: Expression of polycomb group protein EZH2 in nevi and melanoma. J Cutan Pathol; 2007 Aug;34(8):597-600
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  • We sought to determine the pattern of EZH2 expression in benign and malignant melanocytic tumors to see if EZH2 might play a role in melanoma pathogenesis and progression.
  • METHODS: We identified and reviewed 11 compound nevi, 13 dysplastic nevi, 13 Spitz nevi, 9 in situ melanomas, 10 non-metastatic invasive melanomas and 19 melanomas metastatic to lymph nodes from the University of Michigan pathology archives.
  • RESULTS: We observed an incremental increase in EZH2 expression from benign nevi to melanoma: scores of 1.18 and 1.08 for ordinary and dysplastic nevi, 1.7 and 1.78 for Spitz nevi and in situ melanoma, and 1.9 and 3.0 for invasive and metastatic melanoma, respectively.
  • EZH2 expression for metastatic melanoma was significantly higher compared with invasive and in situ melanoma and benign nevi (p < or = 0.01).
  • CONCLUSIONS: EZH2 protein levels increase incrementally from benign nevi to melanoma, which suggests that EZH2 may play a role in the pathogenesis and progression of melanoma.
  • [MeSH-major] DNA-Binding Proteins / metabolism. Melanoma / metabolism. Melanoma / secondary. Nevus / metabolism. Nevus / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Transcription Factors / metabolism
  • [MeSH-minor] Disease Progression. Humans. Immunohistochemistry. Neoplasm Invasiveness. Polycomb Repressive Complex 2. Polycomb-Group Proteins. Repressor Proteins / metabolism

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  • (PMID = 17640228.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K08 CA 090876; United States / NCI NIH HHS / CA / R01 CA 107469
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Polycomb-Group Proteins; 0 / Repressor Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2
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73. Krishna Swaroop DS, Ramakrishna BA, Bai SJ, Shanthi V: Trichoadenoma of Nikolowski. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):277-9
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  • Trichoadenoma of Nikolowski is a rare benign cutaneous tumor, which is usually solitary, nodular and occurs on the face or buttocks any time during adult life.
  • [MeSH-major] Neoplasms, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18603709.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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74. Kazakov DV, Kutzner H, Mukensnabl P, Michal M: Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation. Am J Dermatopathol; 2006 Aug;28(4):341-5
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  • [Title] Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation.
  • The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few.
  • A new case of a cutaneous malignant adnexal neoplasm with multidirectional differentiation is reported here.
  • A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area, which was surgically excised.
  • Microscopically, the neoplasm was located in the dermis with focal extension into the subcutis.
  • We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation.
  • It differs from previously published cases of malignant adnexal tumors with multidirectional differentiation and further exemplifies the spectrum of diversity encountered in malignant proliferations with differentiation toward the folliculosebaceous-apocrine unit.
  • [MeSH-major] Adnexal Diseases / pathology. Cell Differentiation. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Shape. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging

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  • (PMID = 16871040.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • Due to the aggressive course in two cases, the review of the literature does not concentrate on morphology and differential diagnosis only, but discuss overall biology of this lesion too.
  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • There were recognized metastases by one woman in two ipsilateral axillary lymph nodes mimicking benign breast heterotopia in one of them.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • It arises in the deep breast tissue and structurally resembles the microcystic adnexal carcinoma of the skin.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.
  • The rarity of this neoplasm does not exclude deep knowledge.


76. Kaveri H, Punnya A: Pilomatricoma: a dermal analog of calcifying odontogenic cyst. Indian J Dent Res; 2008 Jul-Sep;19(3):261-3
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  • Pilomatricoma, also known as "Calcifying Epithelioma of Malherbe" is an uncommon, benign, cutaneous tumor originating from the hair matrix.
  • Most often, its precise preoperative diagnosis is not possible.
  • We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions.
  • [MeSH-major] Facial Neoplasms / diagnosis. Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans. Orbit / pathology

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  • (PMID = 18797106.001).
  • [ISSN] 0970-9290
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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77. Avninder S, Ramesh V, Vermani S: Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg. Dermatol Online J; 2007;13(2):14
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  • [Title] Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg.
  • Myxoid neurothekeoma is a rare benign cutaneous neoplasm of nerve sheath origin and is also called as benign nerve sheath myxoma.
  • [MeSH-major] Lower Extremity. Neurothekeoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17498433.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Cash SH, Dever TT, Hyde P, Lee JB: Epidermolysis bullosa nevus: an exception to the clinical and dermoscopic criteria for melanoma. Arch Dermatol; 2007 Sep;143(9):1164-7
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  • Although some of the reported cases have an alarming clinical appearance that is indistinguishable from melanoma, long-term follow-up has confirmed the benign nature of these rarely encountered melanocytic lesions.
  • Histopathologically, a pattern of persistent melanocytic neoplasm was observed.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Epidermolysis Bullosa. Humans. Male


79. Magro CM, Seilstad KH, Porcu P, Morrison CD: Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement. Am J Clin Pathol; 2006 Jul;126(1):14-22
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  • [Title] Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement.
  • Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype.
  • Her cutaneous disease progressed despite several cycles of chemotherapy and radiation therapy.
  • Rather than representing an aberrant phenotype, this tumor may represent the malignant counterpart of a benign population of weakly CD20+ T cells of the CD8 subset.
  • [MeSH-major] Antigens, CD / metabolism. Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics. Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / genetics. Immunoglobulin Heavy Chains / genetics. Lymphoma, T-Cell, Cutaneous / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Aged. Antigens, CD20 / metabolism. Antigens, CD8 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Genes, T-Cell Receptor beta / genetics. Humans. Immunophenotyping / methods. Neoplasm Recurrence, Local. Neprilysin / metabolism. Prednisolone / administration & dosage. T-Lymphocyte Subsets / immunology. T-Lymphocyte Subsets / pathology. Vincristine / administration & dosage

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  • (PMID = 16753590.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD20; 0 / Antigens, CD8; 0 / Immunoglobulin Heavy Chains; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; EC 3.4.24.11 / Neprilysin
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80. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
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  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Cardiac transplant patients have an increased incidence of multiple cutaneous neoplasms, but the AF is uncommon.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin, S100 protein and vimentin may be helpful in differential diagnosis.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged. Cyclosporins. Diagnosis, Differential. Humans. Immunosuppressive Agents / adverse effects. Male. Postoperative Complications

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  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
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81. Gomez-Moyano E, Vera-Casaño A, Martinez-Garcia S, Sanz-Trelles A, Crespo-Erchiga V: Two cases of dermatomyofibroma (plaque-like dermal fibromatosis). Int J Dermatol; 2010 Aug;49(8):914-7
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  • BACKGROUND: Dermatomyofibroma is a rare but distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • In both cases, histological examination showed a spindle-cell proliferation embedded among the collagen fibers of the dermis, arranged predominantly parallel to the skin surface.
  • CONCLUSION: Dermatologists and pediatricians should be aware of this benign entity in order to avoid unnecessary treatment.
  • [MeSH-major] Dermis / pathology. Fibroblasts / pathology. Histiocytoma, Benign Fibrous / diagnosis. Muscle, Smooth / pathology. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The International Society of Dermatology.
  • (PMID = 21174375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Deutsch J, Trick D, Delank KW: [Giant scalp mass]. HNO; 2010 Dec;58(12):1204-7
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  • [Transliterated title] Monströser Tumor der Kopfhaut.
  • A 55-year-old man was referred to our department with bleeding from a painless tumor located at the left parietal region of the head which had been progressively growing for a period of 2 years.
  • The partly livid and ulcerated surface of the tumor was interspersed with light-yellow chalky material.
  • Histopathological examination led to the diagnosis of a giant pilomatricoma.
  • Pilomatricoma is a rare, benign skin neoplasm that originates from hair matrix cells and is most frequently located in the head and neck region.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
  • [Cites] J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):191-5 [9704827.001]
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  • (PMID = 20577705.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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83. Fauth CT, Bruecks AK, Temple W, Arlette JP, DiFrancesco LM: Superficial leiomyosarcoma: a clinicopathologic review and update. J Cutan Pathol; 2010 Feb;37(2):269-76
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  • Fourteen tumors were confined to the dermis and 11 involved subcutaneous tissue.
  • Novel histological features included epidermal hyperplasia, sclerotic collagen bands and increasing tumor grade with the depth of the lesion.
  • CONCLUSIONS: SLMSs are rare but important smooth muscle tumors of the skin.
  • The clinical presentation may be non-specific.
  • SLMS can appear low grade or even benign on superficial biopsies, leading to undergrading or a delay in the correct diagnosis.
  • [MeSH-major] Leiomyosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19694881.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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84. Schöttler L, Körber A, Denisjuk N, Freise J, Dissemond J: [Malignant melanoma masquerading as a neurotrophic ulcer]. Med Klin (Munich); 2009 Sep 15;104(9):723-6
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  • After diagnosis and exclusion of metastases, a phase-adapted complete excision was carried out.
  • CONCLUSION: Malignant melanoma is a primary cutaneous malignant tumor.
  • Its thickness at the time of the initial diagnosis is crucial to the prognosis.
  • Ulcerated and amelanotic melanomas still present a considerable clinical challenge due to the likelihood of being mistaken for benign diseases and the occurrence of filiae when diagnosis is made too late.
  • This case report demonstrates the importance of differential diagnostic consideration of neoplasias, for example malignant melanoma, in cases of unclear, therapy-refractory wounds and discusses the relevant aspects in avoiding an unnecessary prolongation of diagnostics.
  • [MeSH-major] Diabetic Foot / diagnosis. Diabetic Nephropathies / diagnosis. Heel. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Interferons / therapeutic use. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Sentinel Lymph Node Biopsy

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  • (PMID = 19779677.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9008-11-1 / Interferons
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85. Clarke LE, Zhang PJ, Crawford GH, Elenitsas R: Myxofibrosarcoma in the skin. J Cutan Pathol; 2008 Oct;35(10):935-40
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  • [Title] Myxofibrosarcoma in the skin.
  • Myxofibrosarcoma, also known as myxoid malignant fibrous histiocytoma, is increasingly recognized as a distinct malignant neoplasm of fibroblastic origin with variable clinical and histopathologic features.
  • Myxofibrosarcomas are among the most common malignant mesenchymal neoplasms of older adults, and approximately two thirds develop within the dermis or subcutis.
  • Herein, we describe the clinicopathologic features of four cases of myxofibrosarcoma involving the skin.
  • Three of these cases were initially misdiagnosed as benign cutaneous neoplasms, two as myxoid neurofibroma.
  • These cases illustrate the clinicopathologic spectrum encompassed by myxofibrosarcoma in the skin and highlight the diagnostic difficulties it may present.
  • [MeSH-major] Fibrosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Fibroma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neurofibroma / pathology

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  • (PMID = 18494817.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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86. Xia W, Longaker MT, Yang GP: P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts. Am J Physiol Regul Integr Comp Physiol; 2006 Mar;290(3):R501-8
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  • Keloids are abnormal fibrous growths of the dermis that develop only in response to wounding and represent a form of benign skin tumor.

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  • (PMID = 16467496.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / K08-GM-069977; United States / NIGMS NIH HHS / GM / R01-GM-65213
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TGFB2 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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87. Mandrell JC, Santa Cruz D: Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? Semin Diagn Pathol; 2009 Aug;26(3):150-63
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  • [Title] Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma?
  • They have been considered a benign neoplasm with involution and complete resolution within few months.
  • Although considered the prototypical example of cutaneous pseudomalignancy, some believe that these tumors are squamous cell carcinomas and through the years there have been sporadic reports of "metastasizing keratoacanthomas".
  • The question has been raised as to whether keratoacanthoma is an unreliable histological diagnosis or these tumors have a latent, albeit rare, malignant potential.
  • Since a benign lesion is incapable of metastasis, some other explanation must be considered; the most likely one being a misdiagnosis.
  • While it is clear that in some cases, the histological and cytological features of squamous cell carcinoma and keratoacanthoma are difficult to distinguish by current techniques, these occasional limitations in diagnosis do not make keratoacanthomas a carcinoma.
  • We believe the evidence supports that keratoacanthomas are benign squamous proliferations.
  • The diagnosis can be made with confidence in appropriate biopsies and using well established clinicopathological criteria.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Keratoacanthoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Diagnostic Errors. Humans. Hyperplasia. Neoplasm Metastasis


88. Chaudhry IH, Calonje E: Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases. Histopathology; 2005 Aug;47(2):179-85
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  • [Title] Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases.
  • AIMS: Cutaneous and soft tissue granular cell tumour is a well-characterized benign neoplasm of neural origin.
  • However, there remains a subcategory of granular cell tumour, first described by Le Boit as 'primitive polypoid granular cell tumour', that shows no obvious line of differentiation.
  • METHODS AND RESULTS: Eleven cases of dermal non-neural granular cell tumour were retrieved from one of the authors referral archives (E.C.) and both the histology and immunohistochemistry reviewed.
  • The tumours were composed of elongated spindle-shaped to polygonal or round cells with prominent granular cell change, and tumour nuclei showing mild focal atypia to rare moderate atypia.
  • Immunohistochemical labelling of the tumour cells demonstrated expression for NKI-C3 (n = 11), focal, weak positivity for CD68 (n = 10) and FXIIIa (n = 2).
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Child. Factor XIIIa / analysis. Female. Humans. Immunohistochemistry. Lysosomes / immunology. Male. Middle Aged

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  • (PMID = 16045779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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89. Ma C, Quesnelle KM, Sparano A, Rao S, Park MS, Cohen MA, Wang Y, Samanta M, Kumar MS, Aziz MU, Naylor TL, Weber BL, Fakharzadeh SS, Weinstein GS, Vachani A, Feldman MD, Brose MS: Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biol Ther; 2009 May;8(10):907-16
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  • [Title] Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.
  • The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2, where allelic loss is both frequent and associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC).
  • To understand the extent of CSMD1 aberrations in vivo, we characterized 184 primary tumors from the head and neck, lung, breast and skin for gene copy number and analyzed expression in our HNSCCs and lung squamous cell carcinomas (SCCs).
  • We detected loss of CSMD1 in a large proportion of HNSCCs (50%), lung (46%) and breast cancers (55%), and to a lesser extent in cutaneous SCCs (29%) and basal cell carcinomas (BCCs, 17%) using array-based comparative genomic hybridization (aCGH).
  • CSMD1 expression was decreased in tumors compared to adjacent benign tissue (65%, 13/20) and was likely due to gene loss in 45% of cases (9/20).
  • We show loss of CSMD1 in primary HNSCC tissues, and document for the first time that CSMD1 is lost in breast, lung and cutaneous SCCs.
  • [MeSH-major] Breast Neoplasms / genetics. Head and Neck Neoplasms / genetics. Lung Neoplasms / genetics. Membrane Proteins / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Case-Control Studies. Chromosome Deletion. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Gene Dosage. Gene Expression. Humans. Loss of Heterozygosity. Mouth Neoplasms / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism


90. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • Syringocystadenoma papilliferum (SCAP) is a rare cutaneous adnexal neoplasm with variable clinical appearance and characteristic histology.
  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • The age at the time of the diagnosis varied from 3 to 48 years with an average age of 28 years.
  • Three tumors were localized in the scalp, 2 in the trunk, and 3 others of unusual locations: 1 in the eyelid, 1 in the thigh and 1 in the popliteal fossa.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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91. Zalaudek I, Ferrara G, Broganelli P, Moscarella E, Mordente I, Giacomel J, Argenziano G: Dermoscopy patterns of fibroepithelioma of pinkus. Arch Dermatol; 2006 Oct;142(10):1318-22
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  • BACKGROUND: Fibroepithelioma of Pinkus (FeP) is a rare variant of basal cell carcinoma that may clinically mimic a number of benign skin tumors.
  • Clinically, no FeP was correctly identified and, in half of all patients, a clinical differential diagnosis of purely benign skin lesions was made.
  • Dermoscopy enabled the correct diagnosis in 9 of 10 FePs, based on the presence of fine arborizing vessels, either alone or associated with dotted vessels, and white streaks (in 100%, 70%, and 90% of lesions, respectively).
  • CONCLUSIONS: Dermoscopy is helpful in diagnosing FeP and in differentiating this variant of basal cell carcinoma from other benign skin tumors commonly included in the clinical differential diagnosis.
  • This presumes, however, that dermoscopy is used as a first-line examination for all skin lesions, not only for those that are clinically suspect.
  • [MeSH-major] Neoplasms, Fibroepithelial / epidemiology. Neoplasms, Fibroepithelial / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Dermoscopy / utilization. Female. Humans. Italy / epidemiology. Male. Medical Records. Middle Aged. Retrospective Studies

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  • (PMID = 17043187.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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92. Zhuang D, Mannava S, Grachtchouk V, Tang WH, Patil S, Wawrzyniak JA, Berman AE, Giordano TJ, Prochownik EV, Soengas MS, Nikiforov MA: C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells. Oncogene; 2008 Nov 6;27(52):6623-34
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  • Intriguingly, the same mutations have been detected at higher incidences in benign nevi, which are largely composed of senescent melanocytes.
  • Reciprocally, overexpression of C-MYC in normal melanocytes suppressed BRAF(V600E)-induced senescence more efficiently than NRAS(Q61R)-induced senescence, which agrees with the generally higher rates of activating mutations in BRAF than NRAS gene in human cutaneous melanomas.

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  • (PMID = 18679422.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA120244-05; United States / NCI NIH HHS / CA / P30 CA046592; United States / NCI NIH HHS / CA / R01 CA107237; United States / NCI NIH HHS / CA / 5 P30 CA46592; United States / NCI NIH HHS / CA / CA107237; United States / NCI NIH HHS / CA / R01 CA120244; United States / NCI NIH HHS / CA / CA120244-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Protein Kinase Inhibitors; 0 / Proto-Oncogene Proteins c-myc; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS248659; NLM/ PMC3808965
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93. Tanaka Y, Bhunchet E, Shibata T: A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. Breast Cancer; 2008;15(2):175-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine spiradenoma (ES) is a fairly common, benign, cutaneous tumor originating from the sweat glands.
  • In contrast, the malignant counterpart of ES, malignant eccrine spiradenoma (MES), is extremely rare.
  • We present the first reported case of this tumor metastasizing to an intramammary lymph node (IMLN).
  • The uncommon metastasizing focus of the periumbilical MES and its histopathological similarity with a primary breast carcinoma made the diagnosis difficult.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18270794.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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94. Velazquez EF, Werchniack AE, Granter SR: Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases. Am J Dermatopathol; 2010 Jun;32(4):333-9
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  • [Title] Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases.
  • Desmoplastic cutaneous squamous cell carcinomas (SCCs) are rare neoplasms with an increased risk of local recurrence and metastasis usually affecting sun-exposed skin of the elderly.
  • To expand this clinicopathologic spectrum, we report 6 cases of an unusual variant of desmoplastic SCC in which the "desmoplastic" areas are predominantly composed of cytologically bland malignant spindle cells mimicking a reactive/benign scarring process.
  • All tumors affected sun-damaged skin of the head and commonly infiltrated into the subcutaneous fat and deeper structures.
  • Accurate recognition of this entity is essential because of potential misdiagnosis as a benign process including scar and dermatofibroma.
  • Careful search for atypical features and squamous differentiation, immunohistochemical studies, and, in some cases, deeper sections are required to establish the diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cicatrix / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology


95. Hussein MR, Elsers DA, Fadel SA, Omar AE: Clinicopathological features of melanocytic skin lesions in Egypt. Eur J Cancer Prev; 2006 Feb;15(1):64-8
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  • [Title] Clinicopathological features of melanocytic skin lesions in Egypt.
  • Although melanocytic skin lesions have been recognized since antiquity, their literature was limited to Caucasians.
  • To define these features, diagnostic records of the melanocytic skin lesions received at the Pathology Department, Assuit University Hospitals (1989-2004) were reviewed.
  • The lesions examined included 12 benign naevi (BN), 10 dysplastic naevi (DN), and 21 cutaneous malignant melanomas (CMMs).
  • The mean tumour thickness (Breslow) was 6+/-0.5 mm.
  • In Egypt, CMM is the third most common cutaneous neoplasm following squamous and basal cell carcinomas.
  • This is the first study that reports the clinicopathologic features of melanocytic skin lesions in Egypt.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 16374232.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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96. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Miracco C, Cevenini G, Franchi A, Luzi P, Cosci E, Mourmouras V, Monciatti I, Mannucci S, Biagioli M, Toscano M, Moretti D, Lio R, Massi D: Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions. Hum Pathol; 2010 Apr;41(4):503-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions.
  • This study was designed to assess the expression of Beclin 1 and LC3 in cutaneous melanocytic lesions, in which they have not yet been investigated.
  • In 149 lesions, including benign nevi, dysplastic nevi, radial growth phase melanomas, vertical growth phase melanomas, and melanoma metastases, proteins were evaluated by immunohistochemistry, and, in representative cases of benign nevi, vertical growth phase melanomas and melanoma metastases were evaluated by Western blotting.
  • Beclin 1 cytoplasmic protein and messenger RNA, as well as LC3 messenger RNA, significantly decreased with tumor progression (P < .05).
  • The percentage of cases with high cytoplasmic expression of beclin 1 from 100% in benign nevi declined to 86.4% in dysplastic nevi, 54.5% in radial growth phase melanomas, 54.3% in vertical growth phase melanomas, and 26.7% in melanoma metastases.
  • In a multivariate analysis, messenger RNAs for both genes discriminated between nonmalignant (benign and dysplastic nevi) and malignant (radial, vertical growth phase melanomas, and melanoma metastases) lesions.
  • Our results, therefore, indicate that beclin 1 and LC3 II autophagic gene expression is altered also in melanocytic neoplasms.
  • [MeSH-major] Apoptosis Regulatory Proteins / biosynthesis. Dysplastic Nevus Syndrome / metabolism. Melanoma / metabolism. Membrane Proteins / biosynthesis. Microtubule-Associated Proteins / biosynthesis. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Autophagy. Humans. Immunohistochemistry. Melanocytes / metabolism. Melanocytes / pathology. Middle Aged. Neoplasm Metastasis. Prognosis. Reverse Transcriptase Polymerase Chain Reaction. Skin / metabolism. Skin / pathology. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc.
  • (PMID = 20004946.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BECN1 protein, human; 0 / Membrane Proteins; 0 / Microtubule-Associated Proteins; 0 / light chain 3, human
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98. Tucker T, Wolkenstein P, Revuz J, Zeller J, Friedman JM: Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology; 2005 Jul 26;65(2):205-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between benign and malignant peripheral nerve sheath tumors in NF1.
  • OBJECTIVE: People with neurofibromatosis type 1 (NF1) have a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST).
  • However, it is not known whether an individual's risk of developing an MPNST is associated with the burden of benign neurofibromas.
  • The authors conducted a study to determine whether people with NF1 who have benign neurofibromas of various kinds are at greater risk of developing MPNSTs than patients with NF1 who lack these benign tumors.
  • METHODS: Clinical information on 476 NF1 probands in the Henri Mondor Database was analyzed by logistic regression to examine associations between MPNSTs and internal plexiform, superficial plexiform, subcutaneous, and cutaneous neurofibromas.
  • CONCLUSIONS: The observation that malignant peripheral nerve sheath tumors are strongly associated with internal plexiform neurofibromas suggests that patients with neurofibromatosis type 1 with these benign tumors warrant increased surveillance for malignancy.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurofibroma, Plexiform / epidemiology. Neurofibromatosis 1 / epidemiology. Peripheral Nerves / pathology
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Life Expectancy. Logistic Models. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Prevalence. Prognosis. Risk Factors. Survival Rate. Tomography, X-Ray Computed / adverse effects. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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  • (PMID = 16043787.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities.
  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • The histological, immunohistochemical (positive for epithelial membrane antigen, collagen type IV, laminin and vimentin but not S-100 protein) and ultrastructural features of a perineurioma form the basis for diagnosis.
  • The unusual case presented herein is a 21-year-old woman manifesting more than 30 cutaneous sclerosing perineuriomas on the hands and arms.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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100. Bechert CJ, Stern JB: Basal cell carcinoma with perineural invasion: reexcision perineural invasion? J Cutan Pathol; 2010 Mar;37(3):376-9
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  • Reexcision perineural invasion (RPI), a benign mimic of tumoral perineural invasion, may present a difficult histologic differential diagnosis.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasm Invasiveness / pathology. Neoplasm Seeding. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies






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