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1. Meek KM: Corneal collagen-its role in maintaining corneal shape and transparency. Biophys Rev; 2009 Jul;1(2):83-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Corneal collagen-its role in maintaining corneal shape and transparency.
  • Corneal collagen has a number of properties that allow it to fulfil its role as the main structural component within the tissue.
  • This review describes the structure and arrangement of corneal collagen from the nanoscopic to the macroscopic level, and how this relates to the maintenance of the form and transparency of the cornea.

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  • (PMID = 28509987.001).
  • [ISSN] 1867-2450
  • [Journal-full-title] Biophysical reviews
  • [ISO-abbreviation] Biophys Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Collagen / Cornea / Structure / Transparency
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2. Tsukahara N, Tani Y, Lee E, Kikuchi H, Endoh K, Ichikawa M, Sugita S: Microstructure characteristics of the cornea in birds and mammals. J Vet Med Sci; 2010 Sep;72(9):1137-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microstructure characteristics of the cornea in birds and mammals.
  • In this study, the microstructure of the cornea was compared among chickens (Gallus gallus), jungle crows (Corvus macrorhynchos), rats (Rattus norvegicus) and rabbits (Oryctolagus cuniculus).

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  • (PMID = 20410677.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Coloring Agents; 9007-34-5 / Collagen
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3. Elias PM: Stratum corneum defensive functions: an integrated view. J Invest Dermatol; 2005 Aug;125(2):183-200
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stratum corneum defensive functions: an integrated view.
  • Regardless of their relative importance, these protective cutaneous functions largely reside in the stratum corneum (SC).

  • COS Scholar Universe. author profiles.
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  • (PMID = 16098026.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR19098; United States / NIAMS NIH HHS / AR / AR39448
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids
  • [Number-of-references] 242
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4. Hirao T, Takahashi M: Carbonylation of cornified envelopes in the stratum corneum. FEBS Lett; 2005 Dec 19;579(30):6870-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carbonylation of cornified envelopes in the stratum corneum.
  • Stratum corneum (SC), the outermost layer of the skin, is continuously exposed to oxidative stress via sunlight, lipid peroxidation, and is subsequently accompanied by oxidative modification.

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  • (PMID = 16336969.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antibodies, Monoclonal; 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Protein Precursors; 0 / Proteins; 0 / Xanthenes; 60108-77-2 / involucrin; 82354-19-6 / Texas red
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5. Karring H, Thøgersen IB, Klintworth GK, Møller-Pedersen T, Enghild JJ: The human cornea proteome: bioinformatic analyses indicate import of plasma proteins into the cornea. Mol Vis; 2006;12:451-60
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The human cornea proteome: bioinformatic analyses indicate import of plasma proteins into the cornea.
  • Increased biochemical knowledge of normal and diseased corneas is essential for the understanding of corneal homeostasis and pathophysiology.
  • In a recent study, we characterized the proteome of the normal human cornea and identified 141 distinct proteins.
  • This dataset represents the most comprehensive protein study of the cornea to date and provides a useful reference for further studies of normal and diseased human corneas.
  • The list of identified proteins is available at the Cornea Protein Database.
  • In the present paper, we review the utilized procedures for extraction and fractionation of corneal proteins and discuss the potential roles of the identified proteins in relation to homeostasis, diseases, and wound-healing of the cornea.
  • Thus, exceptionally few of the traditional blood/plasma proteins and immune defense proteins that were identified in the human cornea were recognized in the gene expression libraries of the cornea.
  • This observation strongly indicates that these abundant corneal proteins are not expressed in the cornea but originate from the surrounding pericorneal tissue.
  • [MeSH-major] Blood Proteins / metabolism. Computational Biology / methods. Cornea / metabolism. Proteome / metabolism

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  • (PMID = 16710169.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01-EY12712
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Proteome
  • [Number-of-references] 91
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6. Fujimoto T, Shirakami K, Tojo K: Effect of microdermabrasion on barrier capacity of stratum corneum. Chem Pharm Bull (Tokyo); 2005 Aug;53(8):1014-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of microdermabrasion on barrier capacity of stratum corneum.
  • A new microdermabrasion system is used for peeling the stratum corneum in a controlled manner.
  • The fine corundum powders ejected by suction power, being quickly in contact with the skin surface, abrade and remove a tiny fragment of stratum corneum.
  • The fraction of the stratum corneum removed by microdermabrasion can be controlled by the operating conditions; the duration of application (L) and the degree of vacuum setting (V).
  • The stratum corneum barrier function with respect to the rate of skin penetration is well correlated by the product of the square of the degree of the vacuum and the duration of the probe setting.

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  • (PMID = 16079538.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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7. Nakashima Y, Yoshitomi F, Oshika T: Clinical evaluation of cornea pseudoguttata. Br J Ophthalmol; 2007 Jan;91(1):22-5
MedlinePlus Health Information. consumer health - Corneal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical evaluation of cornea pseudoguttata.
  • AIM: To report on cornea pseudoguttata which occurred in 44 eyes from 40 patients.
  • RESULTS: Cornea pseudoguttata was found in 44 eyes of 40 patients (1.1%).
  • All patients had some form of anterior-segment ocular diseases, including keratitis (corneal infiltration) with contact lens wear (n = 16), epidemic keratoconjunctivitis (n = 8), corneal epithelial defect (n = 6), superficial punctate keratitis (n = 4), corneal foreign body (n = 3), keratitis of unknown causes (n = 3), corneal ulcer (n = 2), herpetic keratitis (n = 1), and iritis (n = 1).
  • Six eyes were lost to follow-up, but in the remaining 38 eyes, cornea pseudoguttata completely resolved as the primary anterior-segment diseases subsided.
  • Specular microscopy, measured after resolution of cornea pseudoguttata, showed that corneal endothelial cell density was not different between the affected and contralateral healthy eyes.
  • CONCLUSION: Cornea pseudoguttata is commonly found in cases with corneal infiltration and inflammation.
  • These results indicate that cornea pseudoguttata is reversible in its nature and resolves completely without any damage to the corneal endothelial cells.
  • [MeSH-major] Cornea / pathology. Corneal Diseases / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Anterior Eye Segment / pathology. Cell Count. Child. Endothelial Cells / pathology. Endothelium, Corneal / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 16973660.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1857589
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8. Giansanti F, Rapizzi E, Virgili G, Mencucci R, Bini A, Vannozzi I, Menchini U: Clear corneal incision of 2.75 mm for cataract surgery induces little change of astigmatism in eyes with low preoperative corneal cylinder. Eur J Ophthalmol; 2006 May-Jun;16(3):385-393

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear corneal incision of 2.75 mm for cataract surgery induces little change of astigmatism in eyes with low preoperative corneal cylinder.
  • PURPOSE: To assess the early astigmatic effect induced by 2.75 mm clear cornea incisions with different locations for cataract surgery.
  • Computerized videokeratography was used to measure corneal astigmatism before surgery and after 1, 4, and 12 weeks.
  • Corneal astigmatism was recorded as cylinder and axis and it was then converted to 2 power vector.
  • Model based prediction and comparisons were made for the most commonly used corneal incision sites: 12 (both eyes), 2 (left eye), and 8 (right eye) oclock meridian.
  • RESULTS: After 3 months the differences in corneal astigmatism (JCC 0 ) between the incisions performed at 12 and 2 oclock were not statistically significant (-0.08, 95% CI: -0.19, -0.02); the differences in JCC 0 between incisions at 12 and 8 oclock were -0.17 (95% CI: -0.30, -0.05; p<0.01).
  • CONCLUSIONS: This study has shown that a 2.75 mm clear corneal incision causes a small change of corneal cylinder regardless of incision site.

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  • (PMID = 28221468.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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9. van der Beek MT, Bernards AT, Lapid-Gortzak R: Mycobacterium chelonae keratitis in a patient with Sjogren''s syndrome. Eur J Ophthalmol; 2008 Mar-Apr;18(2):294-296

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Upon arrival the left eye showed diffuse corneal edema and centrally several large infiltrates with fluffy edges, surrounded by several smaller satellite infiltrates.
  • The cornea was scraped for culture and grew M chelonae and sensitivity testing showed sensitivity to ciprofloxacin, clofazimine, and clarithromycin.
  • Treatment was continued for a total of 10 months during which the infiltrates cleared completely, but the central cornea remained scarred.
  • Good communication between the ophthalmologist and the microbiologist is crucial for a rapid diagnosis.

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  • (PMID = 28221637.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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10. Mansouri MR, Mirshahi A, Hosseini M: Domestic ocular injuries: A case series. Eur J Ophthalmol; 2007 Jul-Aug;17:654-659

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cornea was involved in 50.0% and sclera, lens, and retina each was involved in 4.8%.

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  • (PMID = 28221564.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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11. Fasce F, Spinelli A, Bolognesi G, Rossi M, Gemma M: Comparison of BD MultiviscTM with the soft shell technique in cases with hard lens nucleus and Fuchs endothelial dystrophy. Eur J Ophthalmol; 2007 Sep-Oct;17(1):709-713

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To compare the efficacy of 2.5% sodium hyaluronate (BD MultiviscTM) with the soft shell technique in reducing corneal endothelial cell damage during cataract phacoemulsification in patients with hard lens nucleus (3+) and cornea guttata.
  • Thirty-seven eyes (randomly divided into Groups A and B) with hard lens nucleus (grade 3 or higher) and cornea guttata had phacoemulsification using the soft shell technique (Group A) with Biolon(R) (sodium hyaluronate 1%) and Viscoat(R) (sodium hyaluronate 3%-chondroitin sulfate 4%) or with BD MultiviscTM alone (Group B).
  • Patients were evaluated preoperatively and after 1, 15, 90, and 180 days, checked for best-corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness, and corneal endothelial density.
  • RESULTS: There were no significant differences between the two groups at 3 and 6 months in BCVA, IOP, corneal thickness, or endothelial cell density.
  • The increase of central corneal thickness (preoperative: Group A 584+/-30 micronm, Group B 573+/-30 micronm; postoperative at 90 days: Group A 593+/-38 micronm, Group B 577+/-25 micronm) was not significant.
  • CONCLUSIONS: The results suggest that the soft shell technique (Biolon(R), Viscoat(R)) and 2.5% sodium hyaluronate (BD MultiviscTM) are both effective in protecting the corneal endothelium in Fuchs dystrophy during phacoemulsification in patients with hard lens nucleus.

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  • (PMID = 28221509.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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12. Saenz-Frances F, Calvo-Gonzalez C, Jimenez-Santos M, Mendez-Hernandez C, Fernandez-Vidal AM, Martinez-De-La-Casa JM, Garcia-Sanchez J, Garcia-Feijoo J: Herpetic optic neuritis associated with herpetic keratitis. Eur J Ophthalmol; 2007 Jul-Aug;17:683-684

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One week later slit lamp examination showed diffuse stromal corneal oedema and a dendritic lesion in the nasal zone of the corneal epithelium.
  • A week later, the optic disc swelling and corneal lesions had resolved.
  • CONCLUSIONS: The precise mechanism through which the papilla and cornea were successively affected in our patient is unclear but the sensitive innervation of both these structures is provided by the nasal branch of the nasociliary nerve and the spread of herpes via this nerve could affect both sites.

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  • (PMID = 28221572.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Pawar PK, Majumdar DK: Effect of formulation factors on in vitro permeation of moxifloxacin from aqueous drops through excised goat, sheep, and buffalo corneas. AAPS PharmSciTech; 2006 Mar;7(1):E89

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Permeation characteristics of drug were evaluated by putting 1 mL formulation on freshly excised cornea (0.50 cm<sup>2</sup>) fixed between donor and receptor compartments of an all-glass modified Franz diffusion cell and measuring the drug permeated in the receptor (containing 10 mL bicarbonate ringer at 37°C under stirring) by spectrophotometry at 291 nm, after 120 minutes.
  • Formulation with benzyl alcohol significantly (P<.05) increased permeation with buffalo cornea compared with its control.

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  • (PMID = 28290028.001).
  • [ISSN] 1530-9932
  • [Journal-full-title] AAPS PharmSciTech
  • [ISO-abbreviation] AAPS PharmSciTech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; concentration / cornea / moxifloxacin / pH / permeation / preservative
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14. Nagy M, Hadházy C, Vigváry L: [General symptoms of cornea Salzmann-type degeneration]. Orv Hetil; 2007 Mar 4;148(9):413-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [General symptoms of cornea Salzmann-type degeneration].
  • [Transliterated title] A cornea Salzmann-féle nodularis degeneratiojával társuló általános tünetek.
  • After a brief review of the symptoms of Salzmann's nodular corneal dystrophy the authors report on 28 patients.
  • The regressive change of the corneal stroma, the hyaline cartilage and the bones relies assumably on an abnormality of their mutual component, the mucopolysaccharides.
  • This explains the relationship between osteoporosis and metabolic disorder of mucopolysaccharides.
  • 3. The remarkably high occurrence of cataracta, in comparison to a normal population of the same age, is presumably related to the metabolic disorder of mucopolysaccharides.
  • 4. The aforesaid seem to confirm that Salzmann's nodular corneal dystrophy, corneal dystrophy is not induced by repeated inflammations but conversely, pathological metabolism of the cornea in consequence of dystrophy is responsible for serial keratitis.
  • [MeSH-major] Bone and Bones / pathology. Cornea / pathology. Corneal Diseases / complications. Corneal Diseases / diagnosis. Glycosaminoglycans / metabolism. Hyaline Cartilage / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Cataract / complications. Diagnosis, Differential. Female. Humans. Keratitis / etiology. Male. Middle Aged. Osteoporosis / chemically induced

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  • (PMID = 17344169.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Glycosaminoglycans
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15. Bailly N, Sherif ZA, Pleyer U, Rieck P: [Confocal microscopy in corneal dystrophies: a comparison between confocal slit scanning (ConfoScan P2) and laser scanning microscopy (Rostock Cornea Modul-HRT II)]. Klin Monbl Augenheilkd; 2006 Sep;223(9):735-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Confocal microscopy in corneal dystrophies: a comparison between confocal slit scanning (ConfoScan P2) and laser scanning microscopy (Rostock Cornea Modul-HRT II)].
  • [Transliterated title] Konfokale Scanning-Mikroskopie: Eine vergleichende Darstellung von Hornhautdystrophiebefunden mittels ConfoScanP2 und Rostock Cornea Modul-HRT II.
  • BACKGROUND: The object of this work was a comparison of confocal images of corneal dystrophies made by a slit scanning microscope versus a laser scanning microscope.
  • MATERIAL AND METHODS: Using the Rostock Cornea Modul-HRT II as a confocal laser scanning microscope the images of five patients with some epithelial, stromal and endothelial corneal dystrophies were acquired.
  • RESULTS: Confocal images from both devices were able to provide significant helpful diagnostic findings about the corneal microstructure.
  • CONCLUSION: Evaluating corneal dystrophies in vivo, an equivalent utility of both technical approaches has been observed.
  • [MeSH-major] Corneal Dystrophies, Hereditary / pathology. Microscopy, Confocal / instrumentation. Ophthalmoscopes

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  • (PMID = 16986083.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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16. Jurowska-Liput J, Krzyzanowska P, Szelepin Ł, Nizankowska MH: [Evaluation on the cellular level the filtering bleb following trabeculectomy, using the HRT II Cornea Module]. Klin Oczna; 2008;110(10-12):343-6
Hazardous Substances Data Bank. MITOMYCIN C .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluation on the cellular level the filtering bleb following trabeculectomy, using the HRT II Cornea Module].
  • [Transliterated title] Przyzyciowa ocena pecherzyka filtracyjnego na poziomie komórkowym za pomoca HRT II Cornea Module.
  • PURPOSE: Evaluation on the cellular level the filtering bleb following trabeculectomy, using the HRT II Cornea Module.

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  • (PMID = 19195162.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin
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17. Aktan M, Okka B, Okka M, Duman S: Improvement In Rabbit Corneal Cell Suspension Viability After Freezing With Gingko Biloba Extrakt. Acta Medica (Hradec Kralove); 2007;50(2):145-148

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improvement In Rabbit Corneal Cell Suspension Viability After Freezing With Gingko Biloba Extrakt.
  • We investigated whether the addition of Gingko Biloba extract (EGb 761) to rabbit corneal epithelial medium before cell freezing improved cell viability after freezing then thawing.
  • After removal of corneas, they were treated with enzymes and the corneal epithelium was prepared as a single cell suspension in freezing media with or without EGb 761.
  • After freezing for two weeks then thawing, a higher cell viability was found in the cornea cell suspensions which had been frozen pretreated with EGb 761 in the media.
  • The improvement with corneal cell viability with EGb 761 pretreatment is postulated to be based on the antioxidant capacity of the plant extract.

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  • (PMID = 28949915.001).
  • [ISSN] 1211-4286
  • [Journal-full-title] Acta medica (Hradec Kralove)
  • [ISO-abbreviation] Acta Medica (Hradec Kralove)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Keywords] NOTNLM ; Cornea Epithelium / Cryopreservation / Gingko Biloba Extract
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18. Chen M, Matsuda H, Wang L, Watanabe T, Kimura MT, Igarashi J, Wang X, Sakimoto T, Fukuda N, Sawa M, Nagase H: Pretranscriptional Regulation of Tgf-β1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali. Mol Ther; 2010 Mar;18(3):519-527

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pretranscriptional Regulation of Tgf-β1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali.
  • : Corneal alkali burns are a serious clinical problem that often leads to permanent visual impairment.
  • In this process, transforming growth factor (Tgf)-β1 is upregulated and involved in the response to corneal injury and the process of corneal stromal scarring.
  • To develop an efficient compound to inhibit Tgf-β1 in the cornea, we designed GB1201, a pyrrole-imidazole (PI) polyamide targeting rat Tgf-β1 gene promoter to the activator protein-1 (AP-1) binding site.
  • Topically administrated GB1201 was distributed immediately to the nuclei of all cell layers of the cornea and remained for 24 hours.
  • A corneal alkali burn model in rats was used to evaluate the therapeutic efficacy of GB1201.
  • GB1201 suppressed the upregulation of Tgf-β1 in the burned cornea, both in the mRNA and protein levels.
  • Moreover, daily treatment with GB1201 for a week significantly improved the corneal tissue wound healing, reduced corneal stromal scarring, and prevented corneal haze formation.

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  • [Copyright] Copyright © 2010 The American Society of Gene & Cell Therapy. Published by Elsevier Inc. All rights reserved.
  • (PMID = 28182879.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Imre L, Resch M, Megyesi M, Németh J: [In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module]. Ophthalmologe; 2007 Aug;104(8):697-700, 702-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module].
  • [Transliterated title] In-vitro-Untersuchung der Mikrostruktur von handelsüblichen ophthalmologischen Suspensionen mittels HRT-II Rostock Cornea Modul.
  • BACKGROUND: To investigate the particles of commercially used ophthalmic suspensions with the HRT II Rostock Cornea Module and to compare them with particle parameters given in the literature.
  • CONCLUSION: Exact and reproducible in vitro microstructural examination of ophthalmic suspensions was possible due to the high resolution of the HRT II Rostock Cornea Module.

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  • [Cites] J Cataract Refract Surg. 1998 May;24(5):672-7 [9610452.001]
  • [Cites] Clin Exp Pharmacol Physiol. 2000 Jul;27(7):558-62 [10874518.001]
  • [Cites] Cornea. 2006 Feb;25(2):127-31 [16371768.001]
  • [Cites] BMC Cell Biol. 2006 Jun 22;7:25 [16790072.001]
  • [Cites] Ophthalmologe. 2002 Apr;99(4):276-80 [12058503.001]
  • (PMID = 17593371.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Colloids; 0 / Ophthalmic Solutions; 0 / Sulfonamides; 0 / Suspensions; 0 / Thiazines; 7S5I7G3JQL / Dexamethasone; 9451Z89515 / brinzolamide; 9PHQ9Y1OLM / Prednisolone; O0ZR1R6RZ2 / Betaxolol
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20. Steiber Z, Ehlers N, Heegaard S, Hjortdal J, Berta A, Prause JU: Brown cornea. Graefes Arch Clin Exp Ophthalmol; 2008 Apr;246(4):537-41
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brown cornea.
  • BACKGROUND: A brown cornea is relatively rare.
  • We report a case of progressive brown corneal pigmentation in a patient with a primary acquired melanosis of the conjunctiva.
  • METHODS: Case report with clinico-pathological correlation and discussion of possible mechanisms of particle clearance of the cornea.
  • RESULTS: A 36-year-old female developed a corneal stromal pigmentation adjacent to a pigmented conjunctival lesion of the left eye.
  • The corneal pigmentation had progressed through 8 years.
  • Despite surgery the corneal pigmentation increased, and visual acuity dropped in the diseased eye.
  • The corneal pigmentation also increased.
  • The host cornea contained pigmented cells in the mid-stroma.
  • CONCLUSIONS: The brown pigmentation of the cornea was due to pigment granules from the iris tumours liberated to the anterior chamber.
  • The pigment was transported into the cornea through the endothelium and accumulated in melanophages between corneal lamellas.
  • The pigment subsequently cleared via the corneal limbus in a process resembling clearance of corneal haemochromatosis.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Corneal Diseases / pathology. Corneal Stroma / ultrastructure. Iris Neoplasms / pathology. Melanoma / pathology. Melanosis / pathology. Nevus, Pigmented / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm / analysis. Eye Enucleation. Female. Humans. Keratoplasty, Penetrating. MART-1 Antigen. Melanocytes / ultrastructure. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. S100 Proteins / analysis

  • MedlinePlus Health Information. consumer health - Corneal Disorders.
  • MedlinePlus Health Information. consumer health - Melanoma.
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  • [Cites] Br J Ophthalmol. 1992 Jul;76(7):444-6 [1627518.001]
  • [Cites] Am J Ophthalmol. 1979 Sep;88(3 Pt 2):592-7 [484690.001]
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  • (PMID = 18193447.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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21. Mazhdrakova I, Demerdjieva Z: [Neovascularisation of the cornea]. Klin Monbl Augenheilkd; 2005 Aug;222(8):623-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neovascularisation of the cornea].
  • [Transliterated title] Neovaskularisation der Hornhaut.
  • The penetration of blood vessels in the cornea causes a reduction of transparency and as a result reduced vision or even blindness.
  • The following methods were used: Split-lamp investigation of the cornea with fluorescein, fluorescein angiography of the corneal neovessels, light and electron microscopy.
  • RESULTS: Application of heparin and methylprednisolone reversibly inhibited the process of neoangiogenesis but intensified the corneal ulcer.
  • The application of cobalt dichloride stimulated angiogenesis in the cornea.
  • CONCLUSIONS: The application of inhibitors of neoangiogenesis decreases the repair processes in corneal lesions with initial neovascularization.
  • The angiogenic factors are distributed by diffusion in the corneal stroma and neovessels initiate from the nearest limbic vessels.
  • [MeSH-major] Corneal Neovascularization / pathology
  • [MeSH-minor] Alkalies. Angiogenesis Inducing Agents / pharmacology. Angiogenesis Inhibitors / pharmacology. Animals. Burns, Chemical / pathology. Cornea / pathology. Corneal Stroma / pathology. Eye Burns / pathology. Fluorescein Angiography. Microcirculation / drug effects. Microcirculation / pathology. Microscopy, Electron. Ophthalmoscopy. Rabbits

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  • (PMID = 16118742.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Alkalies; 0 / Angiogenesis Inducing Agents; 0 / Angiogenesis Inhibitors
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22. Nishida T: [The cornea: stasis and dynamics]. Nippon Ganka Gakkai Zasshi; 2008 Mar;112(3):179-212; discussion 213
MedlinePlus Health Information. consumer health - Corneal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The cornea: stasis and dynamics].
  • The physiological roles of the cornea are to conduct external light into the eye, focus it, together with the lens, onto the retina, and to provide rigidity to the entire eyeball.
  • Good vision thus requires maintenance of the transparency and proper refractive shape of the cornea.
  • Although the cornea appears to be a relatively static structure, dynamic processes operate within and around the cornea at the tissue, cell, and molecular level.
  • In this article, I review the mechanisms responsible for maintenance of corneal homeostasis as well as the development of new modes of treatment for various corneal diseases.
  • I. The static cornea: structure and physiological functions.
  • The cornea is derived from ectoderm, so that it can be considered as transparent skin.
  • The surface of the cornea is covered by tear fluid, which serves both as a lubricant and as a conduit for regulatory molecules.
  • The cornea is also supplied with oxygen and various nutrients by the aqueous humor and a loop vascular system in addition to tear fluid.
  • The cornea interacts with its surrounding tissues directly as well as indirectly through tear fluid or aqueous humor, with such interactions playing an important role in the regulation of corneal structure and functions.
  • The resident cells of the cornea-epithelial cells, fibroblasts (keratocytes), and endothelial cells--also engage in mutual interactions through network systems.
  • These interactions as well as those with infiltrated cells and regulation by nerves contribute to the maintenance of the normal structure and functions of the cornea as well as to the repair of corneal injuries.
  • II. The dynamic cornea: maintenance of structure and functions by network systems.
  • Developments in laser and computer technology have allowed observation of the cells and collagen fibers within the cornea.
  • Furthermore, progress in cell and molecular biology has allowed characterization of dynamic network systems-including cell-cell and cell-extracellular matrix interactions as well as cytokines and neural factors-that contribute to the maintenance of corneal transparency and shape.
  • III. Disruption of network systems: persistent corneal epithelial defects and corneal ulcer.
  • Selection of the appropriate treatment for pathologic lesions of the cornea and the accompanying decrease in visual acuity requires localization of the lesion with regard to the epithelium, stroma, or endothelium of the cornea.
  • In certain instances, however, it is not possible to determine the cause of the problem within the cornea.
  • For example, corneal epithelial wound healing may be delayed, leading to the development of persistent epithelial defects, as a result of disruption of intercellular junctions between epithelial cells, an abnormality of the corneal basement membrane, altered concentrations of various cytokines in tear fluid, a lowered corneal sensation, or allergic reactions in the lid conjunctiva.
  • Loss of corneal epithelial barrier function can further allow inflammatory cytokines present in tear fluid, together with infiltrated cells, to activate keratocytes and elicit excessive degradation of collagen in the stroma, thereby giving rise to corneal ulcer.
  • IV. Development of new drugs for corneal diseases.
  • We have attempted to apply the results of basic scientific research to the development of new drugs for corneal diseases that remain difficult to treat.
  • 1. Development of eyedrops for treatment of persistent corneal epithelial defects.
  • We demonstrated the clinical efficacy of fibronectin eyedrops for the treatment of persistent epithelial defects of the cornea.
  • Furthermore, in seeking an alternative to fibronectin eyedrops, we are investigating the effects of a peptide corresponding to the second cell-binding domain of fibronectin on corneal epithelial wound healing.
  • Considering that urokinase-type plasminogen activator may be expressed at the site of corneal epithelial defects and facilitates epithelial migration, the potential clinical application of annexin V, which stimulates the secretion of urokinase-type plasminogen activator for the treatment of persistent corneal epithelial defects is also now under investigation in Japan.
  • Substance P, a neurotransmitter, stimulates corneal epithelial migration in a synergistic manner with insulin-like growth factor (IGF)--1.
  • We have shown that eyedrops containing both the substance P-derived peptide FGLM-amide and the IGF-1--derived peptide SSSR are effective for the treatment of persistent corneal epithelial defects in individuals with diabetic keratopathy or neurotrophic keratopathy, both of which are associated with a reduction in corneal sensation.
  • 3. Development of drugs for corneal ulcer.
  • Treatment of corneal infection with antibiotics does not necessarily halt the process of corneal ulceration, which is characterized by excessive degradation of stromal collagen, or resolve persistent corneal epithelial defects.
  • In addition to eyedrops for the treatment of persistent corneal epithelial defects, we have therefore also been working on the development of new drugs for the treatment of corneal ulcer.
  • To this end, we have established an experimental system in which corneal fibroblasts are cultured in a three-dimensional collagen gel.
  • With this system, we have shown that triptolide and steroids inhibit collagen degradation by corneal fibroblasts.
  • Triptolide or its derivatives are thus potential drugs for the treatment of corneal ulcer and would work by acting directly on corneal fibroblasts rather than by inhibiting the secreted enzymes(matrix metalloproteinases) responsible for collagen degradation.
  • [MeSH-major] Cornea / physiology. Corneal Diseases / etiology

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  • (PMID = 18411711.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Diterpenes; 0 / Epoxy Compounds; 0 / Fibronectins; 0 / Oligopeptides; 0 / Ophthalmic Solutions; 0 / Phenanthrenes; 0 / phenylalanyl-glycyl-leucyl-methioninamide; 19ALD1S53J / triptolide; EC 3.4.24.- / Matrix Metalloproteinases, Secreted
  • [Number-of-references] 161
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23. Seiler T, Koller T: [Asphericity of the cornea and astigmatism]. Klin Monbl Augenheilkd; 2005 Dec;222(12):977-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Asphericity of the cornea and astigmatism].
  • [Transliterated title] Asphärizität der Hornhaut und Astigmatismus.
  • BACKGROUND: Regarding astigmatism of the cornea, curvature as well as asphericity depend on the meridional axis.
  • METHODS: The astigmatic eye was modelled using a biconoid anterior corneal surface by means of a commercially available optical designer programme (Zemax EE, Zemax).
  • Thirty eyes with astigmatism of up to 5.3 D underwent corneal topography (Keratograph C, Oculus) which allowed a numerical evaluation of the cylindric power as well as the asphericity in the main meridians.
  • RESULTS: The quality of the retinal image of an eye with corneal astigmatism can be improved by a factor of 2.28 if the asphericity is optimised.
  • CONCLUSIONS: Anisotropic asphericity of the cornea may significantly enhance or compensate central corneal astigmatism.
  • Laser correction of corneal astigmatism must take meridional asphericity into account.
  • [MeSH-major] Astigmatism / physiopathology. Astigmatism / surgery. Corneal Topography / methods. Models, Biological. Refraction, Ocular. Retinoscopy / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Computer Simulation. Diagnosis, Computer-Assisted / methods. Humans. Image Interpretation, Computer-Assisted / methods. Keratomileusis, Laser In Situ / methods. Reproducibility of Results. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 16380884.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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24. Safvati A, Cole N, Hume E, Willcox M: Mediators of neovascularization and the hypoxic cornea. Curr Eye Res; 2009 Jun;34(6):501-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediators of neovascularization and the hypoxic cornea.
  • The maintenance of corneal avascularity is essential to vision.
  • The mechanisms by which the cornea becomes vascularized in response to inflammation or hypoxic stress are beginning to be elucidated.
  • A detailed understanding of the molecular responses of the cornea to hypoxia is critical for prevention and development of novel treatments for neovascularization in a range of disease states.
  • Here, we have examined the current literature on the major mediators of angiogenesis, which have previously been reported during hypoxia in the cornea in order to better understand the mechanisms by which corneal angiogenesis occurs in circumstances where the available oxygen is reduced.
  • The normal cornea produces angiogenic factors that are regulated by the production of anti-angiogenic molecules.
  • The various cell types of the cornea respond differentially to inflammatory and hypoxic stimuli.
  • An understanding of the factors that may predispose patients to development of corneal blood vessels may provide an opportunity to develop novel prophylactic strategies.
  • The difficulties with extrapolating data from other cell types and animal models to the cornea are also examined.
  • [MeSH-major] Angiogenesis Inducing Agents / metabolism. Anoxia / metabolism. Corneal Neovascularization / etiology. Corneal Neovascularization / metabolism
  • [MeSH-minor] Cornea / blood supply. Humans

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  • (PMID = 19899985.001).
  • [ISSN] 1460-2202
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents
  • [Number-of-references] 200
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25. Yuan Y, Verma R: Measuring microelastic properties of stratum corneum. Colloids Surf B Biointerfaces; 2006 Mar 1;48(1):6-12
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Measuring microelastic properties of stratum corneum.
  • The elastic modulus (E') of isolated stratum corneum is measured at varying depths through the use of an atomic force microscope (AFM) as well as a nano-indentor (Hysitron Triboscope).
  • Measurements on dry and hydrated stratum corneum show an order of magnitude difference in E' and the measured tandelta (E''/E') is seen to increase from approximately 0.1 to 0.25.
  • The sensitivity of the measurements is tested with applying known treatments to stratum corneum and exploring their effects on biomechanical parameters.

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  • (PMID = 16460919.001).
  • [ISSN] 0927-7765
  • [Journal-full-title] Colloids and surfaces. B, Biointerfaces
  • [ISO-abbreviation] Colloids Surf B Biointerfaces
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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26. Gefen A, Shalom R, Elad D, Mandel Y: Biomechanical analysis of the keratoconic cornea. J Mech Behav Biomed Mater; 2009 Jul;2(3):224-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biomechanical analysis of the keratoconic cornea.
  • Keratoconus is a non-inflammatory disease characterized by irregular thinning and gradual bulging of the cornea, which results in distortion of the corneal surface that causes blurred vision.
  • We conducted three-dimensional finite element (FE) simulations to analyze the biomechanical factors contributing to the distorted shape of a keratoconic cornea.
  • The analyses revealed that three factors affect the shape distortion of keratoconic corneas: (i) localized thinning, and (ii) reduction in the tissue's meridian elastic modulus or (iii) reduction in the shear modulus perpendicular to the corneal surface, whereas thinning showed the most predominant effect.
  • The IOP levels had little influence on dioptric power in the healthy cornea, but a substantial influence in keratoconic conditions.
  • [MeSH-major] Computer Simulation. Cornea / physiopathology. Keratoconus / physiopathology. Models, Biological

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  • (PMID = 19627827.001).
  • [ISSN] 1878-0180
  • [Journal-full-title] Journal of the mechanical behavior of biomedical materials
  • [ISO-abbreviation] J Mech Behav Biomed Mater
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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27. Ayres BD, Rapuano CJ: Refractive power of the cornea. Compr Ophthalmol Update; 2006 Sep-Oct;7(5):243-51; discussion 253-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Refractive power of the cornea.
  • Corneal refractive surgeries, such as laser in situ keratomileusis and photorefractive keratectomy, have become some of the most commonly performed elective surgical procedures today.
  • A common problem in the postrefractive patient is accurate prediction of the corneal power for use in intraocular lens calculation.
  • The purpose of this article is to review the literature and to discuss why it is difficult to determine the power of the postkeratorefractive cornea, and to describe the multiple techniques used to assist in calculation of the power of the cornea.
  • With proper patient history, examination, and careful calculation(s), it is possible to closely estimate the refractive power of the postkeratorefractive cornea.
  • [MeSH-major] Cornea / physiology. Refraction, Ocular / physiology
  • [MeSH-minor] Corneal Topography. Humans

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  • (PMID = 17132433.001).
  • [ISSN] 1527-7313
  • [Journal-full-title] Comprehensive ophthalmology update
  • [ISO-abbreviation] Compr Ophthalmol Update
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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28. Jungersted JM, Høgh JK, Hellgren LI, Jemec GB, Agner T: Ethnicity and stratum corneum ceramides. Br J Dermatol; 2010 Dec;163(6):1169-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ethnicity and stratum corneum ceramides.
  • BACKGROUND: The barrier function of the skin is dependent on an optimal composition of the stratum corneum lipids, exemplified by the altered lipid profile in patients with atopic eczema (AE).
  • OBJECTIVES: To investigate possible differences in stratum corneum lipids between different healthy ethnicities living in the same environment.
  • Twenty-five participants of Asian origin (Asians), 18 of African origin (Africans) and 28 of Danish origin (white-skinned), all students at universities in the Copenhagen area of Denmark, had the ceramide profile of their stratum corneum examined using the cyanoacrylate method and analysed using high-performance thin layer chromatography.

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 21039401.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ceramides; 97C5T2UQ7J / Cholesterol
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29. Zorlutuna P, Tezcaner A, Kiyat I, Aydinli A, Hasirci V: Cornea engineering on polyester carriers. J Biomed Mater Res A; 2006 Oct;79(1):104-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cornea engineering on polyester carriers.
  • In this study, biodegradable polyester based carriers were designed for tissue engineering of the epithelial and the stromal layers of the cornea, and the final construct was tested in vitro.
  • In the construction of the epithelial layer, micropatterned films were prepared from blends of biodegradable and biocompatible polyesters of natural (PHBV) and synthetic (P(L/DL)LA) origin, and these films were seeded with D407 (retinal pigment epithelial) cells.
  • To serve as the stromal layer of the cornea, highly porous foams of P(L/DL)LA-PHBV blends were seeded with 3T3 fibroblasts.
  • On the basis of these results, we concluded that the micropatterned films and the foams made of P(L/DL)LA-PHBV blends have a serious potential as tissue engineering carriers for the reconstruction of the epithelial and stromal layers of the cornea.
  • [MeSH-major] Cornea. Polyesters. Tissue Engineering

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  • [Copyright] (c) 2006 Wiley Periodicals, Inc
  • (PMID = 16758462.001).
  • [ISSN] 1549-3296
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyesters
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30. Lombardo M, Lombardo G, Serrao S: Long-term optical quality of the photoablated cornea. J Opt Soc Am A Opt Image Sci Vis; 2007 Mar;24(3):588-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term optical quality of the photoablated cornea.
  • Corneal aberration data over 3, 5, and 7 mm pupils were collected for up to three years after surgery.
  • The optical performance of the anterior cornea was characterized by estimation of the modulation transfer function (MTF) and the point-spread function.
  • The high-order corneal wavefront aberrations were shown to stabilize one year after surgery.
  • Over photopic pupils, after an early slight increase, corneal RMS-high-order aberrations (HOA) tended to decrease toward preoperative values.
  • On the other hand, over mid- and large-pupil sizes, corneal HOA significantly increased compared with the preoperative state, while the optical performance of the cornea was diminished.
  • [MeSH-major] Cornea / physiopathology. Cornea / surgery. Corneal Topography / methods. Models, Biological. Myopia / physiopathology. Myopia / surgery

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  • (PMID = 17301848.001).
  • [ISSN] 1084-7529
  • [Journal-full-title] Journal of the Optical Society of America. A, Optics, image science, and vision
  • [ISO-abbreviation] J Opt Soc Am A Opt Image Sci Vis
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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31. Elias PM, Choi EH: Interactions among stratum corneum defensive functions. Exp Dermatol; 2005 Oct;14(10):719-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interactions among stratum corneum defensive functions.
  • Yet, the term "barrier function" of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis.

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  • (PMID = 16176279.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 62
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32. Aptel F, Olivier N, Deniset-Besseau A, Legeais JM, Plamann K, Schanne-Klein MC, Beaurepaire E: Multimodal nonlinear imaging of the human cornea. Invest Ophthalmol Vis Sci; 2010 May;51(5):2459-65
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodal nonlinear imaging of the human cornea.
  • PURPOSE: To evaluate the potential of third-harmonic generation (THG) microscopy combined with second-harmonic generation (SHG) and two-photon excited fluorescence (2PEF) microscopies for visualizing the microstructure of the human cornea and trabecular meshwork based on their intrinsic nonlinear properties.
  • METHODS: Fresh human corneal buttons and corneoscleral discs from an eye bank were observed under a multiphoton microscope incorporating a titanium-sapphire laser and an optical parametric oscillator for the excitation, and equipped with detection channels in the forward and backward directions.
  • RESULTS: Original contrast mechanisms of THG signals in cornea with physiological relevance were elucidated.
  • This imaging method should prove particularly useful for assessing glaucoma and corneal physiopathologies.
  • [MeSH-major] Cornea / cytology. Microscopy, Fluorescence, Multiphoton / methods
  • [MeSH-minor] Collagen / analysis. Corneal Edema / pathology. Corneal Stroma / cytology. Endothelium, Corneal / cytology. Epithelium, Corneal / cytology. Eye Banks. Fluorescence Polarization. Humans. Sclera / cytology. Tissue Donors. Trabecular Meshwork / cytology

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  • (PMID = 20071677.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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33. Matsuura T, Ikeda H, Idota N, Motokawa R, Hara Y, Annaka M: Anisotropic swelling behavior of the cornea. J Phys Chem B; 2009 Dec 24;113(51):16314-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anisotropic swelling behavior of the cornea.
  • The phase equilibrium property and structural and dynamical properties of pig cornea were studied by macroscopic observation of swelling behavior, dynamic light scattering (DLS), and small-angle X-ray scattering (SAXS) under various conditions.
  • It was found that the corneal gel collapses into a compact state isotropically or anisotropically depending on the external conditions.
  • The corneal gel collapses uniformly into a compact state at a temperature above 55 degrees C because of the denaturation of collagen, whereas it collapses along an axis parallel to the optic axis with increasing NaCl concentration.
  • SAXS measurements revealed that the periodicity of the collagen fiber of the cornea does not change even at higher NaCl concentration, which indicates that hydration and dehydration resulting from changes in salt concentration simply cause swelling and deswelling of the glycosaminoglycan (GAG), which is located between the regular two-dimensional lattices of collagen fibers, which obliges the change in thickness.
  • From observations of the dynamics of light scattered by the corneal gel, intensity autocorrelation functions that revealed two independent diffusion coefficients were obtained.
  • [MeSH-major] Cornea / chemistry

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  • (PMID = 19954152.001).
  • [ISSN] 1520-5207
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gels
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34. Wang X, Ujihara M, Imae T, Ishikubo A, Sugiyama Y, Okamoto T: Characterization of mimetic lipid mixtures of stratum corneum. Colloids Surf B Biointerfaces; 2010 Jun 15;78(1):92-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of mimetic lipid mixtures of stratum corneum.
  • The lipid mixture, treated at temperature higher than 100 degrees C, displayed the similar thermal character to native human Stratum Corneum (SC), although hydration changed structural characters of the lipid mixtures as well as human SC: Hydration gave rise to the variation of lamellar distances in lipid mixtures such as lengthening of vertical repeat distance and slight-shortening of the lateral repeat distance.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20227254.001).
  • [ISSN] 1873-4367
  • [Journal-full-title] Colloids and surfaces. B, Biointerfaces
  • [ISO-abbreviation] Colloids Surf B Biointerfaces
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ceramides; 0 / Lipids; 2V16EO95H1 / Palmitic Acid; 97C5T2UQ7J / Cholesterol
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35. Chen WL, Sun Y, Lo W, Tan HY, Dong CY: Combination of multiphoton and reflective confocal imaging of cornea. Microsc Res Tech; 2008 Feb;71(2):83-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combination of multiphoton and reflective confocal imaging of cornea.
  • We combine reflective confocal microscopy with multiphoton microscopy to form a minimally invasive technique to observe the cornea.
  • The two imaging modalities allow detection of complementary information from the cornea.
  • The autofluorescence signal shows the cytoplasm of epithelial cells, and the second harmonic generation signal is used to detect collagen, found mostly in the stroma of the cornea.
  • The system is first tested on bovine cornea.
  • [MeSH-major] Cornea / cytology. Image Processing, Computer-Assisted / methods. Microscopy, Confocal / methods
  • [MeSH-minor] Animals. Cattle. Corneal Stroma / cytology. Epithelial Cells / cytology. Keratinocytes / cytology

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  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17902180.001).
  • [ISSN] 1059-910X
  • [Journal-full-title] Microscopy research and technique
  • [ISO-abbreviation] Microsc. Res. Tech.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Shimmura S, Kawakita T: Accessory cell populations in the cornea. Ocul Surf; 2006 Apr;4(2):74-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accessory cell populations in the cornea.
  • According to the "classical" doctrine, resident cells of the cornea include the stratified epithelial cells, quiescent keratocytes, and a single layer of nondividing endothelial cells.
  • However, it has become increasingly evident that other cell types are involved in the homeostasis of the cornea.
  • The presence of various cell types from different lineages has raised concern among researchers as to what we are actually "seeing" in the cornea.
  • Although definitive conclusions cannot yet be drawn, this review attempts to clarify the various accessory cell types reported in the human and murine cornea.
  • The epithelial layer of the limbal area includes melanocytes, as well as antigen-presenting cells that are also present in the peripheral clear cornea.
  • The most debated tissue currently is perhaps the corneal stroma, where resident keratocytes are not as large a population as was previously believed.
  • Bone marrow-derived cells are found in the cornea, and these may not express the typical HLA molecules usually found on the surface of antigen-presenting cells.
  • Although the cell body of the neuron itself is not in the cornea, neural glial cells, such as Schwann cells, are present in the stroma.
  • The use of specific molecular markers and high-quality imaging techniques will be required to fully elucidate the various accessory cells of the cornea and their function.
  • [MeSH-major] Cornea / cytology

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  • [CommentIn] Ocul Surf. 2006 Jul;4(3):119 [16900267.001]
  • (PMID = 16681078.001).
  • [ISSN] 1542-0124
  • [Journal-full-title] The ocular surface
  • [ISO-abbreviation] Ocul Surf
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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37. Henriquez VM, Evinger C: Modification of cornea-evoked reflex blinks in rats. Exp Brain Res; 2005 Jun;163(4):445-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modification of cornea-evoked reflex blinks in rats.
  • Although maintaining the tear film on the cornea is the most important role of blinking, information about the organization and modification of cornea-evoked blinks is sparse.
  • This study characterizes cornea-evoked blinks and their modification in urethane-anesthetized rats.
  • Cornea-evoked blinks typically begin 16.2 ms after an electrical stimulus to the cornea and last an average of 50.2 ms.
  • In response to cornea stimulation, the orbicularis oculi EMG activity typically exhibits two bursts that correlate with the arrival of A delta and C-fiber inputs to the spinal trigeminal complex.
  • In the paired-stimulus paradigm, suppression of the blink evoked by the second cornea stimulus occurs for interstimulus intervals less than 300 ms and is exclusively unilateral.
  • Stimulation of the contralateral cornea does not affect subsequent blinks evoked from stimulation of the ipsilateral cornea.
  • To determine whether activation of cornea-related neurons in the border region between the spinal trigeminal caudalis subdivision and the C1 spinal cord (Vc/C1) inhibits the second blink in the paired-stimulus paradigm, we examine the suppression of cornea-evoked blinks caused by microstimulation in this region.
  • Activation of this region, however, is unlike suppression in the paired-stimulus paradigm because Vc/C1 activation bilaterally inhibits cornea-evoked blinks.
  • Thus, activation of Vc/C1 is a previously unidentified mechanism for modulating cornea-evoked blinks.
  • [MeSH-major] Afferent Pathways / physiology. Blinking / physiology. Cornea / physiology. Eyelids / physiology. Muscle, Skeletal / physiology. Trigeminal Caudal Nucleus / physiology

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  • (PMID = 15785953.001).
  • [ISSN] 0014-4819
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY007391; United States / NEI NIH HHS / EY / EY07391
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
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38. Li LY, Tighe B: The anisotropic material constitutive models for the human cornea. J Struct Biol; 2006 Mar;153(3):223-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The anisotropic material constitutive models for the human cornea.
  • This paper presents an anisotropic analysis model for the human cornea.
  • The model is based on the assumption that the fibrils in the cornea are organised into lamellae, which may have preferential orientation along the superior-inferior and nasal-temporal directions, while the alignment of lamellae with different orientations is assumed to be random.
  • Hence, the cornea can be regarded as a laminated composite shell.
  • [MeSH-major] Cornea / chemistry. Models, Biological

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  • (PMID = 16426861.001).
  • [ISSN] 1047-8477
  • [Journal-full-title] Journal of structural biology
  • [ISO-abbreviation] J. Struct. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Olivier N, Aptel F, Plamann K, Schanne-Klein MC, Beaurepaire E: Harmonic microscopy of isotropic and anisotropic microstructure of the human cornea. Opt Express; 2010 Mar 1;18(5):5028-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Harmonic microscopy of isotropic and anisotropic microstructure of the human cornea.
  • Multiharmonic microscopy provides detailed images of the cornea microstructure over its entire thickness.
  • [MeSH-major] Cornea / anatomy & histology. Microscopy / methods
  • [MeSH-minor] Anisotropy. Computer Simulation. Corneal Stroma / anatomy & histology. Humans. Models, Biological

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  • (PMID = 20389515.001).
  • [ISSN] 1094-4087
  • [Journal-full-title] Optics express
  • [ISO-abbreviation] Opt Express
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Sivamani RK, Stoeber B, Liepmann D, Maibach HI: Microneedle penetration and injection past the stratum corneum in humans. J Dermatolog Treat; 2009;20(3):156-9
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  • [Title] Microneedle penetration and injection past the stratum corneum in humans.
  • However, efficient injection requires complete penetration through the lipophilic stratum corneum.
  • Here, we investigate whether hollow microneedles can penetrate and inject past the stratum corneum in human volunteers.
  • METHODS: Hexyl nicotinate (HN) induces skin capillary vasodilation and was used as the marker of stratum corneum penetration because of its lipophilic nature and slow partition from the lipophilic stratum corneum to the hydrophilic epidermis.
  • RESULTS: Microneedle injections decreased the time to reach maximum cutaneous blood flow by threefold, regardless of whether the stratum corneum had or had not been tape-stripped (p < 0.05).
  • CONCLUSION: Our results demonstrate that hollow microneedle arrays deliver past the stratum corneum and not into the stratum corneum.
  • Therefore, microneedles improve delivery in humans by penetrating past the stratum corneum and would be especially useful in the delivery of lipophilic drugs that partition slowly from the stratum corneum into the epidermis.

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  • (PMID = 19016065.001).
  • [ISSN] 1471-1753
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nicotinic Acids; BN07PB44IV / hexyl nicotinate
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41. Regina M, Zimmerman R, Malik G, Gausas R: Lymphangiogenesis concurrent with haemangiogenesis in the human cornea. Clin Exp Ophthalmol; 2007 Aug;35(6):541-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphangiogenesis concurrent with haemangiogenesis in the human cornea.
  • BACKGROUND: Corneal transplant rejection can occur with and without neovascularization; therefore, it is necessary to elucidate what other factors allow for rejection.
  • It has been suggested that the lymphatic system may play a role in graft failure, but it has also been held that the cornea is devoid of lymphatics.
  • The purpose of this study was to use this new tool to determine if the human cornea can undergo lymphangiogenesis.
  • METHODS: Twelve corneal buttons submitted for routine pathology were subjected to immunohistochemical staining with a monoclonal antibody against D2-40 to detect the presence/absence of lymphatics by light microscopy.
  • RESULTS: By the criteria defined, lymphatic vessels were identified in seven out of 12 corneal buttons.
  • CONCLUSIONS: Corneal lymphatics were identified in association with corneal neovascularization, via the use of a monoclonal antibody against D2-40.
  • [MeSH-major] Cornea / blood supply. Corneal Neovascularization / metabolism. Endothelium, Lymphatic / metabolism. Lymphangiogenesis

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  • (PMID = 17760636.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / monoclonal antibody D2-40
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42. Nakamura T, Kinoshita S: [Current regenerative therapy for the cornea]. Nihon Rinsho; 2008 May;66(5):955-60
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  • [Title] [Current regenerative therapy for the cornea].
  • The cornea is the avascular, transparent, and main optical element of the eye consisting primarily of 3 layers: the corneal epithelium, stroma, and endothelium.
  • It is believed that corneal epithelial stem cells exist in the basal cell layer of the limbal region.
  • In cases of corneal epithelial stem cell deficiency, corneal epithelial replacement using a tissue engineering technique holds great promise for ocular surface reconstruction.
  • Autologous cultivated corneal epithelial sheets are the safest and most reliable treatment, however, they are not useful for treating bilaterally affected ocular surface disorders.
  • In order to treat these bilateral cases, we must choose either an allogeneic cultivated corneal epithelial sheet or an autologous cultivated oral mucosal epithelial sheet.
  • [MeSH-major] Cornea / cytology. Corneal Transplantation / methods. Regenerative Medicine / methods. Stem Cells
  • [MeSH-minor] Cell Differentiation. Cell Proliferation. Epithelium, Corneal / cytology. Humans. Mouth Mucosa / cytology. Tissue Culture Techniques. Tissue Engineering / methods. Tissue Engineering / trends. Transplantation, Autologous. Transplantation, Homologous

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  • (PMID = 18464516.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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43. Rousseau M, Bédouet L, Lati E, Gasser P, Le Ny K, Lopez E: Restoration of stratum corneum with nacre lipids. Comp Biochem Physiol B Biochem Mol Biol; 2006 Sep;145(1):1-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Restoration of stratum corneum with nacre lipids.
  • Using immunofluorescence labelling, we showed that lipids extracted from the mother of pearl of P. margaritifera induced a reconstitution of the intercellular cement of the stratum corneum.

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  • (PMID = 16877020.001).
  • [ISSN] 1096-4959
  • [Journal-full-title] Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • [ISO-abbreviation] Comp. Biochem. Physiol. B, Biochem. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / Lipids; 0 / filaggrin; EC 2.3.2.13 / Transglutaminases; EC 2.3.2.13 / transglutaminase 1
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44. Schroeter J, Rieck P: Endothelial evaluation in the cornea bank. Dev Ophthalmol; 2009;43:47-62
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  • [Title] Endothelial evaluation in the cornea bank.
  • An adequately high endothelial cell density after the culture period is a decisive criterion that must be met before releasing adonor cornea for grafting.
  • [MeSH-major] Cornea. Endothelium, Corneal / cytology. Eye Banks / methods. Organ Preservation
  • [MeSH-minor] Cell Count. Cell Survival. Corneal Transplantation. Graft Survival / physiology. Humans. Organ Culture Techniques. Quality Control. Tissue Donors

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19494636.001).
  • [ISSN] 0250-3751
  • [Journal-full-title] Developments in ophthalmology
  • [ISO-abbreviation] Dev Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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45. Neronov A, Mazgalova J, Cholakova M, Dimitrova M, Deligiozova I, Kovatcheva S, Nikolova E: Integrity of endothelium in cryopreserved human cornea. Cryo Letters; 2005 Mar-Apr;26(2):131-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Integrity of endothelium in cryopreserved human cornea.
  • The aim of the present study was to elaborate an optimal method for cryopreservation of human donor cornea for transplantation and to follow the morphological changes in the structure of the endothelial cell layer using scanning electron microscopy (SEM).
  • Sixteen groups, with four donor cornea each, were cryopreserved at cooling rates of 1 degree C per min and 5 degree C per min.
  • Four additional human cornea were used as controls.
  • Endothelial cell recovery of the cornea after thawing and 24 hours culture, was calculated as a percent of the preserved recovered cells.
  • Sufficient recovery of the endothelial cell layer, making the cornea suitable for transplantation was obtained using the cryoprotectants dimethyl sulfoxide and especially polyethylene glycol-400.
  • [MeSH-major] Corneal Transplantation. Cryopreservation / methods. Endothelium, Corneal / transplantation. Endothelium, Corneal / ultrastructure

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  • (PMID = 15897965.001).
  • [ISSN] 0143-2044
  • [Journal-full-title] Cryo letters
  • [ISO-abbreviation] Cryo Letters
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cryoprotective Agents; 30IQX730WE / Polyethylene Glycols; YOW8V9698H / Dimethyl Sulfoxide
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46. Garralda A, Epelde A, Iturralde O, Compains E, Maison C, Altarriba M, Goldaracena MB, Maraví-Poma E: [Cornea transplant]. An Sist Sanit Navar; 2006;29 Suppl 2:163-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cornea transplant].
  • [Transliterated title] Trasplante de córnea.
  • The keratoplasty, or cornea transplant, is one of the oldest surgical techniques in opthalmology, whose indication are:.
  • 1) tectonic, in order to preserve corneal anatomy and integrity;.
  • 2) clinical, in order to eliminate the inflamed corneal tissue in cases refractory to medical treatment;.
  • [MeSH-major] Corneal Transplantation

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  • (PMID = 16998525.001).
  • [ISSN] 1137-6627
  • [Journal-full-title] Anales del sistema sanitario de Navarra
  • [ISO-abbreviation] An Sist Sanit Navar
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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47. Quinton L, Gaudin K, Baillet A, Chaminade P: Microanalytical systems for separations of stratum corneum ceramides. J Sep Sci; 2006 Feb;29(3):390-8
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  • [Title] Microanalytical systems for separations of stratum corneum ceramides.
  • The advantages of this method are the use of a normal stationary phase more reliable due to its chemical stability, its surface homogeneity and its development in microchromatography without chlorinated solvents which offers small LOD and the whole profile of lipids present in stratum corneum (SC).

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  • (PMID = 16544881.001).
  • [ISSN] 1615-9306
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ceramides; 0 / Solvents; 7631-86-9 / Silicon Dioxide; 9002-89-5 / Polyvinyl Alcohol
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48. Gill HS, Andrews SN, Sakthivel SK, Fedanov A, Williams IR, Garber DA, Priddy FH, Yellin S, Feinberg MB, Staprans SI, Prausnitz MR: Selective removal of stratum corneum by microdermabrasion to increase skin permeability. Eur J Pharm Sci; 2009 Sep 10;38(2):95-103
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective removal of stratum corneum by microdermabrasion to increase skin permeability.
  • This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability.
  • Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues.
  • In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen.
  • In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.

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  • [Cites] Dermatol Surg. 2000 Aug;26(8):754-6 [10940062.001]
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  • (PMID = 19559791.001).
  • [ISSN] 1879-0720
  • [Journal-full-title] European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • [ISO-abbreviation] Eur J Pharm Sci
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / P30 AI050409; United States / NIBIB NIH HHS / EB / R01 EB006369; None / None / / R01 EB006369-01A1; None / None / / R01 EB006369-02; United States / NIBIB NIH HHS / EB / R01 EB006369; United States / NIBIB NIH HHS / EB / R01 EB006369-02; United States / NIBIB NIH HHS / EB / R01 EB006369-01A1; United States / NIAID NIH HHS / AI / U01 AI074579
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS128130; NLM/ PMC2731013
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49. Khan AO, Al-Katan H, Al-Gehedan S, Al-Rashed W: Bilateral congenital stromal cyst of the cornea. J AAPOS; 2007 Aug;11(4):400-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral congenital stromal cyst of the cornea.
  • Stromal corneal cysts have not been documented in histological studies of congenital corneal leukoma.
  • We describe a bilateral congenital case in which the cysts occupied posterior excavations of the cornea and the affected infant developed angle-closure glaucoma.

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  • (PMID = 17360203.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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50. Arya SK, Malik A, Samra SG, Gupta S, Gupta H, Sood S: Squamous cell carcinoma of cornea. Int Ophthalmol; 2008 Oct;28(5):379-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma of cornea.
  • PURPOSE: To report a case of isolated squamous cell carcinoma of cornea.
  • RESULTS: An 80-year-old man presented with decreased vision and a white gelatinous mass on his left cornea.
  • Histopathology of the mass revealed it to be an invasive well-differentiated squamous cell carcinoma of cornea.
  • CONCLUSIONS: Isolated squamous cell carcinoma of cornea, though a rare entity, should be kept in mind in patients with any corneal mass.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Corneal Diseases / pathology. Eye Neoplasms / pathology

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  • (PMID = 17898932.001).
  • [ISSN] 0165-5701
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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51. Zhao XC, Yee RW, Norcom E, Burgess H, Avanesov AS, Barrish JP, Malicki J: The zebrafish cornea: structure and development. Invest Ophthalmol Vis Sci; 2006 Oct;47(10):4341-8
ZFIN. ZFIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The zebrafish cornea: structure and development.
  • PURPOSE: To evaluate the zebrafish as a model for the studies of corneal development and disease.
  • METHODS: Zebrafish embryos and larvae at various stages of development were used for documenting corneal morphogenesis and differentiation.
  • Corneal samples were collected from embryos, larvae, and adult zebrafish for histologic and electron microscopy analysis.
  • Expression patterns of corneal polypeptides were investigated by immunostaining of sections.
  • RESULTS: The zebrafish cornea develops rapidly during embryogenesis, so that its three major layers, the epithelium, the stroma, and the endothelium, are well formed by day 3 postfertilization.
  • The subsequent steps of corneal differentiation, such as the thickening of the corneal stroma, proceed relatively slowly.
  • Several polypeptides are highly enriched in the epithelium or the stroma of the larval and adult zebrafish cornea and are excellent markers of corneal differentiation.
  • CONCLUSIONS: Development and differentiation of the zebrafish cornea are easily accessible to analysis.
  • Anatomic and ultrastructural characterization of the zebrafish cornea demonstrates many similarities to the human cornea and provides the basis for the use of the zebrafish model both to analyze the basic genetic mechanisms of corneal development and to study the causes of corneal disease.
  • [MeSH-major] Cornea / embryology. Cornea / growth & development. Zebrafish / anatomy & histology
  • [MeSH-minor] Animals. Cell Differentiation. Corneal Stroma / cytology. Embryo, Nonmammalian / anatomy & histology. Embryonic Development. Endothelium, Corneal / cytology. Epithelium, Corneal / cytology. Eye Proteins / metabolism. Immunohistochemistry. Morphogenesis

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  • (PMID = 17003424.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY016859; United States / NEI NIH HHS / EY / EY11882; United States / NEI NIH HHS / EY / P30EY10608; United States / NEI NIH HHS / EY / P30EY14104; United States / NEI NIH HHS / EY / R01 EY13117
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins
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52. Kao WW, Xia Y, Liu CY, Saika S: Signaling pathways in morphogenesis of cornea and eyelid. Ocul Surf; 2008 Jan;6(1):9-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Signaling pathways in morphogenesis of cornea and eyelid.
  • Interactions and signaling between mesenchymal and epithelial cells are essential for morphogenesis, organogenesis, cell differentiation, and growth of cornea and eyelids during embryogenesis.
  • This review discusses known signaling transduction pathways involved in the morphogenesis of the cornea and eyelids during embryonic development and homeostasis in adults, using genetically modified experimental animal models.
  • [MeSH-major] Cornea / embryology. Eyelids / embryology. Morphogenesis / physiology. Signal Transduction / physiology

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  • (PMID = 18264652.001).
  • [ISSN] 1542-0124
  • [Journal-full-title] The ocular surface
  • [ISO-abbreviation] Ocul Surf
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-010556; United States / NEI NIH HHS / EY / EY-011845; United States / NEI NIH HHS / EY / EY-012486; United States / NEI NIH HHS / EY / EY-013755; United States / NEI NIH HHS / EY / EY-015227
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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53. Russell LM, Wiedersberg S, Delgado-Charro MB: The determination of stratum corneum thickness: an alternative approach. Eur J Pharm Biopharm; 2008 Aug;69(3):861-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The determination of stratum corneum thickness: an alternative approach.
  • The individual thickness of the stratum corneum is required to normalise drug permeation profiles in dermato-pharmacokinetic studies.
  • This is typically due to the removal of loose outer layers of stratum corneum, which do not contribute significantly to barrier function.
  • The results suggest that the linear model may overestimate the stratum corneum thickness and is open to subjectivity regarding the selection of data points to be fitted.

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  • (PMID = 18424094.001).
  • [ISSN] 0939-6411
  • [Journal-full-title] European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • [ISO-abbreviation] Eur J Pharm Biopharm
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / EB001420-03; United States / NIBIB NIH HHS / EB / R01 EB001420; United States / NIBIB NIH HHS / EB / EB-001420; United States / NIBIB NIH HHS / EB / R01 EB001420-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adhesives
  • [Other-IDs] NLM/ NIHMS66499; NLM/ PMC2577912
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54. Tabernero J, Klyce SD, Sarver EJ, Artal P: Functional optical zone of the cornea. Invest Ophthalmol Vis Sci; 2007 Mar;48(3):1053-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional optical zone of the cornea.
  • PURPOSE: When keratorefractive surgery is used to treat a central corneal diameter smaller than the resting pupil, visual symptoms of polyopia, ghosting, blur, haloes, and glare can be experienced.
  • METHODS: Corneal topography examination results from 1 eye of 34 unoperated normal eyes and 32 myopic eyes corrected by laser in situ keratomileusis (LASIK) were evaluated in three ways.
  • First, a uniform axial power method (FOZ(A)) assessed the area of the postoperative cornea that was within a +/-0.5-D window centered on the mathematical mode.
  • Second, FOZ was determined based on the corneal wavefront true RMS error as a function of the simulated pupil size (FOZ(R)).
  • CONCLUSIONS: These methods will be useful to more fully characterize corneal treatment profiles after keratorefractive surgery.
  • Because of its ease of implementation, direct spatial correspondence to corneal topography, and good correlation to the other more computationally intensive methods, the semiempiric uniform axial power method (FOZ(A)) appears to be most practical in use.
  • [MeSH-major] Cornea / physiopathology. Keratomileusis, Laser In Situ. Myopia / physiopathology. Refraction, Ocular / physiology
  • [MeSH-minor] Algorithms. Corneal Topography. Humans. Retrospective Studies. Sensory Thresholds / physiology

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  • (PMID = 17325146.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY02377; United States / NEI NIH HHS / EY / EY03311
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Khan AO, Aldahmesh M, Meyer B: Recessive cornea plana in the Kingdom of Saudi Arabia. Ophthalmology; 2006 Oct;113(10):1773-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recessive cornea plana in the Kingdom of Saudi Arabia.
  • OBJECTIVE: To characterize the molecular genetics of clinically diagnosed recessive cornea plana in the Kingdom of Saudi Arabia and establish the presence of common or limited founders (ancestors who originally harbored the disease-causing mutation) in the country's historically isolated population.
  • PARTICIPANTS: Twelve affected patients from apparently unrelated Saudi Arabian nuclear families with clinically diagnosed recessive cornea plana.
  • RESULTS: All 12 individuals had classic phenotypic features of recessive cornea plana and were homozygous for 1 of 2 KERA mutations--a novel frameshift mutation (1634delC) or a previously reported nonsense mutation (R313X).
  • CONCLUSION: Specific for mutation in KERA, the ophthalmic phenotype of recessive cornea plana does not significantly vary with different KERA mutations.
  • [MeSH-major] Corneal Dystrophies, Hereditary / genetics. Eye Proteins / genetics. Genes, Recessive. Proteoglycans / genetics

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  • (PMID = 17011957.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon, Nonsense; 0 / DNA Primers; 0 / Eye Proteins; 0 / KERA protein, human; 0 / Proteoglycans
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56. Du LQ, Wu XY, Li MC, Wang SG, Pang KP: Effect of different biomedical membranes on alkali-burned cornea. Ophthalmic Res; 2008 Oct;40(6):282-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of different biomedical membranes on alkali-burned cornea.
  • OBJECTIVE: To evaluate the effects of different biomedical membranes on alkali-burned cornea in vivo.
  • The right cornea of each rabbit was made into an alkali-burned model with 1 mmol/l NaOH.
  • The reepithelialization of each cornea was evaluated with fluorescein staining and 3 corneas of each group were excised to observe histological changes such as corneal wound healing, inflammation and collagen synthesis.
  • CONCLUSION: PDLLA/chitosan promoted wound healing of alkali-burned corneas in vivo and decreased scar tissue formation, while the effect of the PDLLA/collagen and PDLLA membranes was to promote corneal ulcers, which suggests that PDLLA/chitosan membrane transplantation is a potential effective strategy for treatment of alkali-burned cornea.
  • [MeSH-major] Burns, Chemical / surgery. Corneal Diseases / surgery. Eye Burns / chemically induced. Membranes, Artificial
  • [MeSH-minor] Animals. Chitosan. Collagen. Disease Models, Animal. Epithelium, Corneal / physiology. Lactic Acid. Polymers. Rabbits. Sodium Hydroxide. Wound Healing / physiology

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18463426.001).
  • [ISSN] 1423-0259
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Membranes, Artificial; 0 / Polymers; 26100-51-6 / poly(lactic acid); 33X04XA5AT / Lactic Acid; 55X04QC32I / Sodium Hydroxide; 9007-34-5 / Collagen; 9012-76-4 / Chitosan
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57. Ayala A, Warejecka DJ, Vaughan KA, Twining SS, Yue BY: The fibrinolysis inhibitor alpha2-antiplasmin in the human cornea. Curr Eye Res; 2005 Dec;30(12):1097-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The fibrinolysis inhibitor alpha2-antiplasmin in the human cornea.
  • PURPOSE: To determine whether the cornea contains and expresses, at the gene level, the major plasmin inhibitor alpha2-antiplasmin.
  • METHODS: Corneal sections were immunostained for alpha2-antiplasmin.
  • Extracts of human corneal stroma, epithelium, and endothelium were subjected to immunodot blot and Western blot analysis.
  • RESULTS: Alpha2-antiplasmin was observed in all three corneal layers by immunolocalization and Western blots.
  • Alpha2-antiplasmin mRNA was detected in epithelial and stromal extracts and cultured human corneal stromal cells.
  • CONCLUSIONS: Alpha2-antiplasmin and its mRNA are present in the cornea and may serve to regulate corneal plasmin activity.

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  • (PMID = 16354623.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY012731; United States / NEI NIH HHS / EY / R01-EY12931; United States / NEI NIH HHS / EY / P30-EY-10931; United States / NEI NIH HHS / EY / R01 EY012731-04; United States / NEI NIH HHS / EY / R01 EY 03890
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifibrinolytic Agents; 0 / RNA, Messenger; 0 / alpha-2-Antiplasmin
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58. Kotecha A: What biomechanical properties of the cornea are relevant for the clinician? Surv Ophthalmol; 2007 Nov;52 Suppl 2:S109-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What biomechanical properties of the cornea are relevant for the clinician?
  • Although the effects of central corneal thickness and corneal curvature on intraocular pressure measurement are well known, it has only recently become possible to measure the biomechanical properties of the cornea in vivo.
  • This article reviews the structural and material properties of the cornea and considers the effects of corneal parameters, including biomechanics, on IOP measurement.
  • The role of corneal biomechanics as a potential indicator of the structural integrity of the globe will also be discussed.
  • Current evidence suggests that the importance of corneal biomechanics to the glaucoma clinician rests primarily with its effects on IOP measurement.
  • However, the possibility that corneal biomechanics may give an indication of the structural integrity of the optic nerve head cannot be completely excluded.
  • Further population and longitudinal studies are needed to clarify whether current in vivo measures of corneal biomechanical properties, including corneal hysteresis, prove to be independent predictors of glaucoma susceptibility.
  • [MeSH-major] Cornea / anatomy & histology. Cornea / physiology. Intraocular Pressure / physiology

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  • (PMID = 17998034.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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59. Avetisov SE, Novikov IA, Bubnova IA, Antonov AA, Siplivyĭ VI: [Investigation of the biomechanical properties of the cornea by bidirectional applanation: new approaches to interpreting the results]. Vestn Oftalmol; 2008 Sep-Oct;124(5):22-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Investigation of the biomechanical properties of the cornea by bidirectional applanation: new approaches to interpreting the results].
  • This study deals with the biomechanical properties of the cornea, which is essential in solving different problems of clinical ophthalmology, specifically in predicting the potential complications of keratorefraction operations, in early diagnosing keratoconus, and interpreting the measurements of intraocular pressure.
  • The investigations confirmed the efficiency of using bidirectional applanation of the cornea to define its strength characteristics.
  • A procedure has been also developed to estimate the elasticity coefficient which reflects the elastic properties of the cornea irrespective of intraocular pressure values.
  • [MeSH-major] Cornea / physiology. Intraocular Pressure / physiology. Keratoconus / diagnosis. Ocular Hypertension / diagnosis. Tonometry, Ocular / methods
  • [MeSH-minor] Adolescent. Adult. Antihypertensive Agents / therapeutic use. Biomechanical Phenomena. Corneal Topography. Corneal Transplantation. Elasticity. Humans. Middle Aged. Models, Biological

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  • (PMID = 19062553.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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60. Khan AO, Aldahmesh MA, Al-Gehedan S, Meyer BF, Alkuraya FS: Corneal decompensation in recessive cornea plana. Ophthalmic Genet; 2009 Sep;30(3):142-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Corneal decompensation in recessive cornea plana.
  • PURPOSE: To report corneal decompensation in 3 patients with recessive cornea plana.
  • RESULTS: An adult and two children (all unrelated) with clinical recessive cornea plana had gradual decrease in vision.
  • Ophthalmic examination revealed corneal decompensation (stromal thickening and haze without epithelial changes) in the 3 patients.
  • CONCLUSIONS: The phenotype of recessive cornea plana can rarely include corneal decompensation.
  • [MeSH-major] Corneal Diseases / genetics. Corneal Diseases / pathology

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  • [ErratumIn] Ophthalmic Genet. 2009 Dec;30(4):208. Meyer, Brain F [corrected to Meyer, Brian F]
  • (PMID = 19941419.001).
  • [ISSN] 1744-5094
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KERA protein, human; 0 / Proteoglycans
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61. Papadia M, Barabino S, Valente C, Rolando M: Anatomical and immunological changes of the cornea in patients with pterygium. Curr Eye Res; 2008 May;33(5):429-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anatomical and immunological changes of the cornea in patients with pterygium.
  • PURPOSE: To test the hypothesis that anatomical and immunological changes are present in the cornea of patients affected by pterygium.
  • MATERIALS AND METHODS: The central cornea of 20 eyes of 18 patients with primary pterygium was examined by in vivo confocal microscopy using a 40x lens and an axial resolution of 5 microm.
  • CONCLUSIONS: In vivo confocal microscopy may be helpful in evaluating the immunological and structural changes of the cornea in patients with pterygium and understanding its pathophysiology and the possible role of anti-inflammatory therapy.
  • [MeSH-major] Corneal Diseases / immunology. Corneal Diseases / pathology. Pterygium / pathology
  • [MeSH-minor] Adult. Case-Control Studies. Cell Count. Dendritic Cells / pathology. Epithelium, Corneal / pathology. Female. Humans. Male. Microscopy, Confocal. Middle Aged. Prospective Studies

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  • (PMID = 18568879.001).
  • [ISSN] 1460-2202
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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62. Shankar V, Roberts F, Ramaesh K: Histopathological changes of cornea in long-term sympathetic ophthalmitis. Cornea; 2010 Nov;29(11):1287-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological changes of cornea in long-term sympathetic ophthalmitis.
  • PURPOSE: To report the histopathological changes occurring in the cornea in sympathetic ophthalmitis.
  • We report the histopathological features of the cornea.
  • CONCLUSIONS: Endothelial loss and development of bullous keratopathy associated with band keratopathy are predominate histopathological features of the cornea.
  • [MeSH-major] Cornea / pathology. Keratoplasty, Penetrating. Ophthalmia, Sympathetic / pathology. Ophthalmia, Sympathetic / surgery
  • [MeSH-minor] Bowman Membrane / pathology. Calcinosis / etiology. Child. Chronic Disease. Corneal Diseases / etiology. Corneal Diseases / pathology. Corneal Edema / etiology. Corneal Edema / pathology. Descemet Membrane / pathology. Endothelium, Corneal / pathology. Female. Humans. Male. Young Adult

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  • (PMID = 20802313.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Rogers MS, Birsner AE, D'Amato RJ: The mouse cornea micropocket angiogenesis assay. Nat Protoc; 2007;2(10):2545-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The mouse cornea micropocket angiogenesis assay.
  • The mouse corneal micropocket angiogenesis assay uses the avascular cornea as a canvas to study angiogenesis in vivo.
  • A micropocket is surgically created in the mouse cornea and a pellet implanted.
  • Five days later, the area of the cornea overgrown by the angiogenic response is measured using a slit lamp.
  • [MeSH-major] Cornea / blood supply. Corneal Neovascularization

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  • (PMID = 17947997.001).
  • [ISSN] 1750-2799
  • [Journal-full-title] Nature protocols
  • [ISO-abbreviation] Nat Protoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 62031-54-3 / Fibroblast Growth Factors
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64. Quantock AJ, Young RD, Akama TO: Structural and biochemical aspects of keratan sulphate in the cornea. Cell Mol Life Sci; 2010 Mar;67(6):891-906

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Structural and biochemical aspects of keratan sulphate in the cornea.
  • Keratan sulphate (KS) is the predominant glycosaminoglycan (GAG) in the cornea of the eye, where it exists in proteoglycan (PG) form.
  • KS-PGs have long been thought to play a pivotal role in the establishment and maintenance of the array of regularly-spaced and uniformly- thin collagen fibrils which make up the corneal stroma.
  • This characteristic arrangement of fibrils allows light to pass through the cornea.
  • Indeed, perturbations to the synthesis of KS-PG core proteins in genetically altered mice lead to structural matrix alterations and corneal opacification.
  • Similarly, mutations in enzymes responsible for the sulphation of KS-GAG chains are causative for the inherited human disease, macular corneal dystrophy, which is manifested clinically by progressive corneal cloudiness starting in young adulthood.
  • [MeSH-major] Cornea / chemistry. Cornea / metabolism. Keratan Sulfate / chemistry. Keratan Sulfate / metabolism

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  • (PMID = 20213925.001).
  • [ISSN] 1420-9071
  • [Journal-full-title] Cellular and molecular life sciences : CMLS
  • [ISO-abbreviation] Cell. Mol. Life Sci.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0600755; United Kingdom / Biotechnology and Biological Sciences Research Council / / B18021; United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D001919/1; United Kingdom / Biotechnology and Biological Sciences Research Council / / BBS/B/10994; United States / NEI NIH HHS / EY / EY014620
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 9056-36-4 / Keratan Sulfate
  • [Number-of-references] 184
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65. Read SA, Collins MJ, Carney LG, Franklin RJ: The topography of the central and peripheral cornea. Invest Ophthalmol Vis Sci; 2006 Apr;47(4):1404-15
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The topography of the central and peripheral cornea.
  • PURPOSE: To investigate the topography of the central and peripheral cornea in a group of young adult subjects with a range of normal refractive errors.
  • METHODS: Corneal topography data were acquired for 100 young adult subjects by a method that allows central and peripheral maps to be combined to produce one large, extended corneal topography map.
  • Corneal height, axial radius of curvature, and axial power data were analyzed.
  • The corneal height data were also fit with Zernike polynomials.
  • RESULTS: Conic fitting to the corneal height data revealed the average apical radius (Ro) was 7.77 +/- 0.2-mm and asphericity (Q) was -0.19 +/- 0.1 for a 6-mm corneal diameter.
  • The conic fit parameters were both found to change significantly for increasing corneal diameters.
  • For a 10-mm corneal diameter, Ro was 7.72 +/- 0.2 mm and Q was -0.36 +/- 0.1.
  • A slight but significant meridional variation was found in Q, with the steepest principal corneal meridian found to flatten at a slightly greater rate than the flattest meridian.
  • The RMS fit error for the conic section was found to increase markedly for larger corneal diameters.
  • Higher-order polynomial fits were needed to fit the peripheral corneal data adequately.
  • Analysis of the axial power data revealed highly significant changes occurring in the corneal best-fit spherocylinder with increasing distance from the corneal center.
  • The peripheral cornea was found to become significantly flatter and to decrease slightly in its toricity.
  • Individual subjects exhibited a range of different patterns of central and peripheral corneal topography.
  • Several of the higher order corneal surface Zernike coefficients were found to change significantly with increasing corneal diameter.
  • CONCLUSIONS: Highly significant changes occur in the shape of the cornea in the periphery.
  • On average, the peripheral cornea becomes significantly flatter and slightly less astigmatic than the central cornea.
  • A conic section is a poor estimator of the peripheral cornea.
  • [MeSH-major] Cornea / pathology. Corneal Topography. Refractive Errors / pathology

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  • (PMID = 16565374.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Cursiefen C: Immune privilege and angiogenic privilege of the cornea. Chem Immunol Allergy; 2007;92:50-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immune privilege and angiogenic privilege of the cornea.
  • The cornea is the transparent window of the eye and corneal transparency is essential for good vision.
  • Inflammatory reactions within the cornea cannot only cause tissue destruction and scar formation, but are also associated with angiogenesis and lymphangiogenesis in the cornea.
  • Both inflammation-associated processes interfere with corneal transparency and cause corneal blindness.
  • During evolution the cornea has developed mechanisms for preventing and modulating inflammatory and angiogenic reactions.
  • The fact that the cornea is normally devoid of both blood and lymphatic vessels and actively maintains this avascularity has been termed 'corneal angiogenic privilege'.
  • Corneal 'immune privilege', on the other hand, indicates that the cornea is an immune-privileged site and tissue, enabling the extraordinary success of histologically incompatible corneal transplantation.
  • Recent evidence indicates that there is considerable overlap in the molecular mechanisms maintaining corneal 'angiogenic' and 'immune privilege'.
  • [MeSH-major] Cornea / blood supply. Cornea / immunology. Neovascularization, Physiologic
  • [MeSH-minor] Angiogenesis Inhibitors / therapeutic use. Animals. Corneal Transplantation. Humans. Lymphangiogenesis

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  • (PMID = 17264482.001).
  • [ISSN] 1660-2242
  • [Journal-full-title] Chemical immunology and allergy
  • [ISO-abbreviation] Chem Immunol Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors
  • [Number-of-references] 30
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67. Read SA, Buehren T, Collins MJ: Influence of accommodation on the anterior and posterior cornea. J Cataract Refract Surg; 2007 Nov;33(11):1877-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of accommodation on the anterior and posterior cornea.
  • PURPOSE: To evaluate whether significant change occurs in the topography of the anterior or posterior cornea or in corneal thickness with accommodation.
  • METHODS: Corneal data were acquired for 12 young, healthy emmetropic subjects under 2 accommodation levels (relaxed and approximately 5.0 diopters) using a rotating Scheimpflug camera.
  • Anterior and posterior corneal elevation and sagittal curvature data as well as pachymetry data were analyzed to evaluate changes associated with accommodation.
  • Corneal elevation data were also analyzed using a recentering procedure designed to minimize the effect of ocular micromovements between measurements.
  • RESULTS: Changes in corneal parameters resulting from accommodation were small and generally insignificant.
  • No significant change was found in the best-fit corneal spherocylinder (anterior and posterior cornea) (P>.05).
  • Small changes were found in the corneal cylinder axis, indicative of small cyclotorsional eye movements accompanying accommodation.
  • The mean changes in corneal elevation were 0.09 +/- 0.41 microm (anterior cornea) and 0.17 +/- 0.65 microm (posterior cornea).
  • Only 0.50% (anterior cornea) and 0.27% (posterior cornea) of corneal elevation data points exhibited a statistically significant change with accommodation.
  • Recentering the corneal elevation data led to a reduction in the magnitude of change in corneal elevation with accommodation.
  • When these eye movements were accounted for in data analysis, no consistent significant change in the topography of the cornea was found with accommodation across an 8.0 to 9.0 mm corneal diameter.
  • [MeSH-major] Accommodation, Ocular / physiology. Cornea / physiology
  • [MeSH-minor] Adult. Corneal Topography. Endothelium, Corneal / physiology. Epithelium, Corneal / physiology. Eye Movements / physiology. Female. Humans. Male. Photography

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  • (PMID = 17964392.001).
  • [ISSN] 0886-3350
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Kaye SB, Neal T, Nicholson S, Szkurlat J, Bamber S, Baddon AC, Anderson S, Seddon K, Dwyer N, Lovering AM, Smith G: Concentration and bioavailability of ciprofloxacin and teicoplanin in the cornea. Invest Ophthalmol Vis Sci; 2009 Jul;50(7):3176-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concentration and bioavailability of ciprofloxacin and teicoplanin in the cornea.
  • PURPOSE: To investigate the concentration and bioavailability of ciprofloxacin and teicoplanin in the cornea.
  • METHODS: A biological assay was developed with corneal tissue used as a carrier for the antimicrobial.
  • Concentration and biological activity were determined with a chemical assay and zone of inhibition (ZOI) around corneal samples with epithelial and endothelial surfaces in contact with the indicator organism.
  • RESULTS: There were good correlations between antimicrobial concentration and ZOI, when either filter paper or corneal discs were used (R(2) > 92%).
  • Of 33 patients, the mean (median) concentration of ciprofloxacin in the cornea was 1.37 mg/L (0.46 mg/L) and 1.89 mg/L (1.44 mg/L; bioassay) in the epithelial and endothelial orientations, respectively, and 14.87 mg/L (7.41) in the cornea and 0.51 mg/L (0.42) in the aqueous (chemical assay).
  • For teicoplanin, the mean (median) concentration in the cornea was 9.58 mg/L (0 mg/L) in the epithelial and 4.78 mg/L (0 mg/L) in the endothelial orientations (bioassay).
  • In the chemical assay, teicoplanin could not be detected in the cornea or aqueous at the lower limit of detection of 3.6 mg/L.
  • CONCLUSIONS: The ZOI produced by corneal tissue provides a potential bioassay of antimicrobial activity and concentration.
  • Although in contrast to teicoplanin ciprofloxacin shows good corneal penetration, with high endothelial-to-epithelial levels, only approximately 10% of measured levels in a chemical assay are available, according to a bioassay.
  • Teicoplanin shows relatively poor corneal penetration through intact epithelium.
  • These methods may be useful in evaluating the biological activity across the cornea of antimicrobials introduced into ophthalmic practice to deal with changing bacterial resistance.
  • [MeSH-major] Anti-Bacterial Agents / pharmacokinetics. Ciprofloxacin / pharmacokinetics. Cornea / metabolism. Teicoplanin / pharmacokinetics
  • [MeSH-minor] Animals. Aqueous Humor / metabolism. Biological Availability. Corneal Diseases / metabolism. Corneal Diseases / surgery. Escherichia coli / drug effects. Fluorescence Polarization Immunoassay. Humans. Keratoplasty, Penetrating. Microbial Sensitivity Tests. Staphylococcus aureus / drug effects. Swine

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  • (PMID = 19218614.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 5E8K9I0O4U / Ciprofloxacin; 61036-62-2 / Teicoplanin
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69. Beyer J, Zhao XC, Yee R, Khaliq S, McMahon TT, Ying H, Yue BY, Malicki JJ: The role of crumbs genes in the vertebrate cornea. Invest Ophthalmol Vis Sci; 2010 Sep;51(9):4549-56
ZFIN. ZFIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of crumbs genes in the vertebrate cornea.
  • PURPOSE: To evaluate the role of crumbs genes and related epithelial polarity loci in the vertebrate cornea.
  • The expression of the CRB1 gene in the normal human cornea was examined by polymerase chain reaction (PCR) and immunohistochemical staining.
  • In addition, the layering of the corneal stroma is poorly formed or absent.
  • A PCR product of the correct size was obtained from normal human corneal samples.
  • Immunohistochemical staining using anti-CRB1 yielded positive brown deposits in the human cornea.
  • CONCLUSIONS: crumbs genes play a role in the differentiation of the vertebrate cornea.
  • Corneal defects associated with crumbs gene mutations are very severe in the zebrafish model and, in comparison, appear clinically less pronounced in the human eye.

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  • (PMID = 20805571.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY01792; United States / NEI NIH HHS / EY / P30 EY001792; United States / NEI NIH HHS / EY / EY017571; United States / NEI NIH HHS / EY / EY018728; United Kingdom / Wellcome Trust / / 063406/Z/2000/Z; United States / NEI NIH HHS / EY / EY03890; United States / NEI NIH HHS / EY / R21 EY018728; United States / NEI NIH HHS / EY / EY016859; United States / NEI NIH HHS / EY / R01 EY016859; United States / NEI NIH HHS / EY / EY10608; United States / NEI NIH HHS / EY / R01 EY011882; United States / NEI NIH HHS / EY / R01 EY003890; United States / NEI NIH HHS / EY / P30 EY010608; United States / NEI NIH HHS / EY / R03 EY017571
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRB1 protein, human; 0 / Crb1 protein, zebrafish; 0 / Eye Proteins; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Zebrafish Proteins
  • [Other-IDs] NLM/ PMC2941173
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70. Boote C, Hayes S, Young RD, Kamma-Lorger CS, Hocking PM, Elsheikh A, Inglehearn CF, Ali M, Meek KM: Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. J Struct Biol; 2009 May;166(2):195-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea.
  • In the cornea, the precise organisation of fibrillar collagen and associated proteoglycans comprising the stromal extracellular matrix plays a major role in governing tissue form and function.
  • Here we further characterize corneal ultrastructural changes as the rge eye develops post-hatch.
  • Wide-angle X-ray scattering disclosed alteration to dominant collagen lamellae directions in the rge chick cornea, compared to age-matched controls.
  • These changes accompanied eye globe enlargement and corneal flattening in affected birds, manifesting as a progressive loss of circumferential collagen alignment in the peripheral cornea and limbus in birds older than 1 month.
  • However, small-angle X-ray scattering results suggest collagen fibril separation and diameter increase more rapidly towards the corneal periphery in rge at 3 months post-hatch compared to controls, although central collagen fibril diameter was unchanged.
  • From a numerical simulation of tissue mechanics, progressive remodelling of stromal collagen in rge during globe enlargement post-hatch appears to be related to the corneal morphometric changes presented by the disease.
  • [MeSH-major] Cornea / pathology. Cornea / ultrastructure. Corneal Diseases / metabolism. Corneal Diseases / pathology. Retinal Diseases / metabolism. Retinal Diseases / pathology

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  • (PMID = 19258040.001).
  • [ISSN] 1095-8657
  • [Journal-full-title] Journal of structural biology
  • [ISO-abbreviation] J. Struct. Biol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0600755; United Kingdom / Medical Research Council / / G0501050; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Wellcome Trust / / 074165; United Kingdom / Department of Health / / HTD 539; United Kingdom / Medical Research Council / / G0001033
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Other-IDs] NLM/ PMC2680986
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71. Hill JR, Wertz PW: Structures of the ceramides from porcine palatal stratum corneum. Lipids; 2009 Mar;44(3):291-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Structures of the ceramides from porcine palatal stratum corneum.
  • Ceramides are the major type of lipid found in stratum corneum from the skin, gingiva and hard palate.
  • The present study examined the ceramides of the stratum corneum from the hard palate.
  • ASl, ASs and AP from palatal stratum corneum were essentially identical to their epidermal counterparts.

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  • (PMID = 19184160.001).
  • [ISSN] 1558-9307
  • [Journal-full-title] Lipids
  • [ISO-abbreviation] Lipids
  • [Language] eng
  • [Grant] United States / PHS HHS / / R01 DEO18032; United States / PHS HHS / / T32DEO 07288; United States / PHS HHS / / T32DEO 14678
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ceramides
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72. Dupps WJ Jr, Wilson SE: Biomechanics and wound healing in the cornea. Exp Eye Res; 2006 Oct;83(4):709-20
MedlinePlus Health Information. consumer health - Laser Eye Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biomechanics and wound healing in the cornea.
  • The biomechanical and wound healing properties of the cornea undermine the predictability and stability of refractive surgery and contribute to discrepancies between attempted and achieved visual outcomes after LASIK, surface ablation and other keratorefractive procedures.
  • Furthermore, patients predisposed to biomechanical failure or abnormal wound healing can experience serious complications such as keratectasia or clinically significant corneal haze, and more effective means for the identification of such patients prior to surgery are needed.
  • In this review, we describe the cornea as a complex structural composite material with pronounced anisotropy and heterogeneity, summarize current understanding of major biomechanical and reparative pathways that contribute to the corneal response to laser vision correction, and review the role of these processes in ectasia, intraocular pressure measurement artifact, diffuse lamellar keratitis (DLK) and corneal haze.
  • The current understanding of differences in the corneal response after photorefractive keratectomy (PRK), LASIK and femtosecond-assisted LASIK are reviewed.
  • Surgical and disease models that integrate corneal geometric data, substructural anatomy, elastic and viscoelastic material properties and wound healing behavior have the potential to improve clinical outcomes and minimize complications but depend on the identification of preoperative predictors of biomechanical and wound healing responses in individual patients.

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  • (PMID = 16720023.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY010056-13; United States / NICHD NIH HHS / HD / HD049091; United States / NEI NIH HHS / EY / EY010056; United States / NEI NIH HHS / EY / EY015638; United States / NCRR NIH HHS / RR / KL2 RR024990; United States / NEI NIH HHS / EY / R24 EY015638; United States / NEI NIH HHS / EY / R01 EY010056-13; United States / NICHD NIH HHS / HD / K12 HD049091; United States / NEI NIH HHS / EY / R01 EY010056
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Number-of-references] 120
  • [Other-IDs] NLM/ NIHMS118771; NLM/ PMC2691611
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73. Hazlett LD: Bacterial infections of the cornea (Pseudomonas aeruginosa). Chem Immunol Allergy; 2007;92:185-94
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bacterial infections of the cornea (Pseudomonas aeruginosa).
  • Recent advances in the field have been made using animal models, including inbred murine models that are classed as resistant (cornea heals) versus susceptible (cornea perforates).
  • Overall, studies with these inbred mice provide a better understanding of the mechanisms of innate immune responsiveness and abrogation of immune privilege operative after P. aeruginosa corneal infection.

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  • (PMID = 17264494.001).
  • [ISSN] 1660-2242
  • [Journal-full-title] Chemical immunology and allergy
  • [ISO-abbreviation] Chem Immunol Allergy
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30EY04068; United States / NEI NIH HHS / EY / R01EY02986; United States / NEI NIH HHS / EY / R01EY16058
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Chemokine CCL4; 0 / Interleukin-18; 0 / Macrophage Inflammatory Proteins; 0 / Toll-Like Receptors; 187348-17-0 / Interleukin-12; 82115-62-6 / Interferon-gamma
  • [Number-of-references] 55
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74. Rankl C, Zhu R, Luengo GS, Donovan M, Baghdadli N, Hinterdorfer P: Detection of corneodesmosin on the surface of stratum corneum using atomic force microscopy. Exp Dermatol; 2010 Nov;19(11):1014-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of corneodesmosin on the surface of stratum corneum using atomic force microscopy.
  • Corneodesmosin, a protein known to be present in the stratum corneum (SC), plays an important role in its physical integrity.

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 21182673.001).
  • [ISSN] 1600-0625
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / CDSN protein, human; 0 / Cross-Linking Reagents; 0 / Glycoproteins; 0 / Immunoglobulin G
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75. Shoham A, Hadziahmetovic M, Dunaief JL, Mydlarski MB, Schipper HM: Oxidative stress in diseases of the human cornea. Free Radic Biol Med; 2008 Oct 15;45(8):1047-55
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxidative stress in diseases of the human cornea.
  • Here, we review the roles of oxidative stress in the etiopathogeneses and pathophysiology of diseases of the human cornea including pterygium, keratoconus, trauma and chemical injury, and a host of inflammatory, metabolic, degenerative, and iatrogenic conditions.
  • [MeSH-major] Corneal Diseases / etiology. Oxidative Stress / physiology

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  • (PMID = 18718524.001).
  • [ISSN] 0891-5849
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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76. Krüger A, Hovakimyan M, Ramírez DF, Stachs O, Lubatschowski H, Wree A, Guthoff R, Heisterkamp A: [Two-photon microscopy of the cornea using intrinsic contrast]. Klin Monbl Augenheilkd; 2009 Dec;226(12):970-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two-photon microscopy of the cornea using intrinsic contrast].
  • [Transliterated title] Farbstofffreie Zweiphotonenmikroskopie der Augenhornhaut.
  • BACKGROUND: Three-dimensional imaging of the cornea under physiological conditions is best performed with intrinsic contrast mechanisms for the visualisation of cells and extracellular matrix.
  • However, the unique transparency of the cornea goes along with a lack of contrast for the extracellular matrix (ECM) in reflective mode microscopy and optical coherence tomography.
  • For the visualisation of the cornea and its layered substructures two non-linear contrast mechanisms are of main interest: Two-photon excited autofluorescence of NAD(P)H in the cytoplasma and second harmonic generation (SHG) in the collagen-I fibres of the stroma.
  • RESULTS: Using the autofluorescence of NAD(P)H the corneal epithelium with squamous cells, wing cells and basal cells is visualised in three dimensions without additional exogenoeus staining.
  • The en-face SHG images detected through the transparent cornea in forward direction show areas of parallel streaks, which increase in size and periodically alter in orientation (90 degrees , 45 degrees) with increasing depth from anterior to posterior.
  • CONCLUSION: These results and current reports on applications in the literature show that femtosecond laser-based non-linear microscopy is an emerging imaging modality which provides dye-free imaging of the corneal ECM and therefore complements scattering imaging modalities such as optical coherence tomography and confocal laser scanning microscopy in the reflective mode.
  • [MeSH-major] Epithelial Cells / cytology. Epithelium, Corneal / cytology. Image Enhancement / methods. Microscopy, Confocal / methods. Microscopy, Fluorescence, Multiphoton / methods

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20108191.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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77. Massig JH, Lingelbach E, Lingelbach B: Videokeratoscope for accurate and detailed measurement of the cornea surface. Appl Opt; 2005 Apr 20;44(12):2281-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Videokeratoscope for accurate and detailed measurement of the cornea surface.
  • The eyes of 18 individuals were investigated, and fine structures were found on these cornea surfaces.
  • [MeSH-major] Corneal Topography / instrumentation. Image Enhancement / instrumentation. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Imaging, Three-Dimensional / instrumentation. Ophthalmoscopes. Video Recording / instrumentation

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  • (PMID = 15861833.001).
  • [ISSN] 0003-6935
  • [Journal-full-title] Applied optics
  • [ISO-abbreviation] Appl Opt
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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78. Rosenbaum K, Rottler J, Steinbach R, Huber KK: [Reduced availability of potential cornea donors: reasons and suggestions]. Klin Monbl Augenheilkd; 2010 May;227(5):418-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Reduced availability of potential cornea donors: reasons and suggestions].
  • [Transliterated title] Limitierte Verfügbarkeit von potenziellen Hornhaut-Spendern: Gründe und Verbesserungsvorschläge.
  • AIM: The purpose of the study was to analyse the number of potential cornea donors in relationship to the number of actual donors.
  • Furthermore, in 16 organisational problems caused a failure in cornea donation.
  • [MeSH-major] Corneal Transplantation / psychology. Corneal Transplantation / utilization. Tissue Donors / psychology. Tissue Donors / supply & distribution

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  • (PMID = 20217636.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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79. Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T: Safety of UVA-riboflavin cross-linking of the cornea. Cornea; 2007 May;26(4):385-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety of UVA-riboflavin cross-linking of the cornea.
  • PURPOSE: To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach.
  • RESULTS: The currently used UVA radiant exposure of 5.4 mJ/cm and the corresponding irradiance of 3 mW/cm2 is below the known damage thresholds of UVA for the corneal endothelium, lens, and retina.
  • In a 400-microm-thick cornea saturated with riboflavin, the irradiance at the endothelial level was 0.18 mW/cm, which is a factor of 2 smaller than the damage threshold.
  • CONCLUSIONS: After corneal X-linking, the stroma is depopulated of keratocytes approximately 300 microm deep.
  • As long as the cornea treated has a minimum thickness of 400 microm (as recommended), the corneal endothelium will not experience damage, nor will deeper structures such as lens and retina.
  • [MeSH-major] Cornea / drug effects. Cornea / radiation effects. Cross-Linking Reagents. Photochemotherapy. Photosensitizing Agents / adverse effects. Riboflavin / adverse effects. Ultraviolet Rays / adverse effects
  • [MeSH-minor] Animals. Collagen / drug effects. Collagen / radiation effects. Corneal Stroma / drug effects. Corneal Stroma / radiation effects. Endothelium, Corneal / drug effects. Endothelium, Corneal / radiation effects. Fibroblasts / drug effects. Fibroblasts / radiation effects. Free Radicals. Humans. Radiation Tolerance

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  • [CommentIn] J Refract Surg. 2012 Feb;28(2):91-2 [22313434.001]
  • (PMID = 17457183.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Free Radicals; 0 / Photosensitizing Agents; 9007-34-5 / Collagen; TLM2976OFR / Riboflavin
  • [Number-of-references] 36
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80. Shaozhen Z, Jin-rong Z, Xiaorong L, Ruihua W, Xiaomin Z, Zhihong D: Microstructure of the cornea in high myopia with confocal microscope through focusing in vivo. Ann Ophthalmol (Skokie); 2009 Fall-Winter;41(3-4):162-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microstructure of the cornea in high myopia with confocal microscope through focusing in vivo.
  • We prospectively investigated the changes of microstructure of the cornea in 54 high myopias with confocal microscopy via focusing in vivo.
  • The microstructure of high myopic cornea is different from that of low and moderate myopia, however, whether corneal function would be involved is not clear.
  • [MeSH-major] Cornea / pathology. Fixation, Ocular. Microscopy, Confocal / methods. Myopia / pathology

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  • (PMID = 20214048.001).
  • [ISSN] 1530-4086
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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81. Wray LS, Orwin EJ: Recreating the microenvironment of the native cornea for tissue engineering applications. Tissue Eng Part A; 2009 Jul;15(7):1463-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recreating the microenvironment of the native cornea for tissue engineering applications.
  • A viable tissue-engineered corneal replacement needs to be transparent and mechanically resilient.
  • We hypothesize that the best scaffolding material will mimic the microenvironment of the natural corneal extracellular matrix (ECM).
  • This work describes a method for electrospinning collagen type I fibers that replicates the unique morphology and arrangement of collagen type I fibers in the native cornea.
  • In the cornea the collagen type I fibers are approximately 30 nm in diameter and aligned within stacked lamellae.
  • Rabbit corneal fibroblasts were cultured on the fiber constructs for 7 days.
  • Qualitative analysis of the cell morphology and intracellular protein expression suggests that the electrospun fibers provide a viable scaffold material for engineering a corneal tissue replacement.
  • [MeSH-major] Cornea / physiology. Tissue Engineering / methods

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  • (PMID = 19193140.001).
  • [ISSN] 1937-335X
  • [Journal-full-title] Tissue engineering. Part A
  • [ISO-abbreviation] Tissue Eng Part A
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Cross-Linking Reagents; 0 / Solutions
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82. Studer H, Larrea X, Riedwyl H, Büchler P: Biomechanical model of human cornea based on stromal microstructure. J Biomech; 2010 Mar 22;43(5):836-42
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biomechanical model of human cornea based on stromal microstructure.
  • The optical characteristics of the human cornea depends on the mechanical balance between the intra-ocular pressure and intrinsic tissue stiffness.
  • A wide range of ophthalmic surgical procedures alter corneal biomechanics to induce local or global curvature changes for the correction of visual acuity.
  • Due to the large number of surgical interventions performed every day, a deeper understanding of corneal biomechanics is needed to improve the safety of these procedures and medical devices.
  • The aim of this study is to propose a biomechanical model of the human cornea, based on stromal microstructure.
  • [MeSH-major] Cornea / anatomy & histology. Cornea / physiology. Intraocular Pressure / physiology. Models, Biological

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20006338.001).
  • [ISSN] 1873-2380
  • [Journal-full-title] Journal of biomechanics
  • [ISO-abbreviation] J Biomech
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Das C, Noro MG, Olmsted PD: Simulation studies of stratum corneum lipid mixtures. Biophys J; 2009 Oct 7;97(7):1941-51
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simulation studies of stratum corneum lipid mixtures.
  • We present atomistic molecular dynamics results for fully hydrated bilayers composed of ceramide NS-24:0, free fatty acid 24:0 and cholesterol, to address the effect of the different components in the stratum corneum (the outermost layer of skin) lipid matrix on its structural properties.
  • This indicates that the observed composition ratio in the stratum corneum lipid layer is responsible for both the good barrier properties and the stability of the lipid structure against mechanical stresses.

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  • (PMID = 19804725.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ceramides; 0 / Lipid Bilayers; 059QF0KO0R / Water
  • [Other-IDs] NLM/ PMC2756355
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84. Pinsky PM, van der Heide D, Chernyak D: Computational modeling of mechanical anisotropy in the cornea and sclera. J Cataract Refract Surg; 2005 Jan;31(1):136-45
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Computational modeling of mechanical anisotropy in the cornea and sclera.
  • PURPOSE: To determine the biomechanical deformation of the cornea resulting from tissue cutting and removal by use of a new computational model and to investigate the effect of mechanical anisotrophy resulting from the fibrillar architecture.
  • Results show it is important for the model to incorporate preexisting corneal physiological stress caused by intraocular pressure.
  • CONCLUSIONS: The mathematical model described appears to provide a framework for further development, capturing the essential features of mechanical anisotropy of the cornea.
  • [MeSH-major] Astigmatism / physiopathology. Cornea / physiopathology. Models, Theoretical. Sclera / physiopathology. Surgical Flaps

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  • (PMID = 15721706.001).
  • [ISSN] 0886-3350
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Jacobi U, Gautier J, Sterry W, Lademann J: Gender-related differences in the physiology of the stratum corneum. Dermatology; 2005;211(4):312-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gender-related differences in the physiology of the stratum corneum.
  • OBJECTIVE: In the present study, the effect of gender on the physiology of the stratum corneum was studied.
  • In addition, stratum corneum samples, removed by tape stripping, were studied for amount, spectroscopic properties, protein content, and mass.

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16286738.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Proteins
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86. Zhang ZY, Chu RY, Zhang XR, Hoffman MR, Zhou XT: Effects of femtosecond laser-assisted multilayer intrastromal ablation in the midperipheral cornea. J Cataract Refract Surg; 2010 Nov;36(11):1807-10
MedlinePlus Health Information. consumer health - Laser Eye Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of femtosecond laser-assisted multilayer intrastromal ablation in the midperipheral cornea.
  • The technique was performed in 2 patients, both of whom experienced a decrease in mean corneal power.
  • The multilayer intrastromal ablation technique, which flattens the cornea and decreases corneal power, can be used to correct moderate myopia without injuring the corneal epithelium.
  • [MeSH-major] Corneal Stroma / surgery. Corneal Surgery, Laser / methods. Lasers, Semiconductor / therapeutic use. Myopia / surgery
  • [MeSH-minor] Aged. Corneal Topography. Female. Humans. Visual Acuity / physiology

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  • [Copyright] Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21029884.001).
  • [ISSN] 1873-4502
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Lin HT, Liu ZG, Ling SQ, Xu CC, Zhao W, Li Q, Liang LY: [Exploration of lymphangiogenesis in alkali burned human cornea]. Zhonghua Yan Ke Za Zhi; 2009 Feb;45(2):115-21
MedlinePlus Health Information. consumer health - Corneal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Exploration of lymphangiogenesis in alkali burned human cornea].
  • OBJECTIVE: To explore the lymphangiogenesis process in alkali burned human cornea and to discuss factors modulating this process.
  • Twenty-two cases (22 eyes) of hospitalized patients suffering from alkali burned cornea and requiring keratoplasty from January to December 2005 were analyzed retrospectively.
  • Cornea specimens were assessed for lymphatic vessel counting (LVC) and blood vessel counting (BVC) via immunohistochemical staining and transmission electronic microscopy.
  • Meanwhile, HE staining was also performed to observe infiltration of polymorphonuclear (PMN) leucocytes in corneal tissues.
  • Lymphatic index may be a convenient and useful clinical index for evaluating lymphangiogenesis in corneal alkali burn.
  • [MeSH-major] Burns, Chemical / pathology. Corneal Injuries. Eye Burns / pathology. Lymphangiogenesis

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  • (PMID = 19573329.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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88. Geissler A, Sion S, Toulisse A, Maitrejean C, Paoli K, Durand-Gasselin J: [Cornea donation: improving hospital coordination]. J Fr Ophtalmol; 2005 Mar;28(3):252-6
MedlinePlus Health Information. consumer health - Organ Donation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cornea donation: improving hospital coordination].
  • [Transliterated title] Prélèvements de cornées: améliorer les performances d'une coordination hospitalière.
  • PURPOSE: To evaluate the impact of procedures developed to increase cornea donation in a general hospital.
  • The rate of cornea donors increased from 6% to 20% of the hospital's deaths.
  • CONCLUSION: The consideration of all hospital deaths, the use of a written protocol of contraindications for cornea donation and the wide use of telephone interviews to obtain family consent led to a dramatic increase in cornea donation.
  • [MeSH-major] Cornea. Hospitals. Tissue Donors. Tissue and Organ Harvesting. Tissue and Organ Procurement
  • [MeSH-minor] Corneal Transplantation. Eye Banks. Family. France. Hospital Mortality. Humans. Inpatients. Interviews as Topic

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  • (PMID = 15883489.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] France
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89. Mohan RR, Sharma A, Netto MV, Sinha S, Wilson SE: Gene therapy in the cornea. Prog Retin Eye Res; 2005 Sep;24(5):537-59
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene therapy in the cornea.
  • The cornea is an excellent candidate for gene therapy because of its accessibility and immune-privileged nature.
  • In the last two decades, various viral vectors, such as adeno, adeno-associated, retro, lenti, and herpes simplex, as well as non-viral methods, were examined for introducing DNA into corneal cells in vitro, in vivo and ex vivo.
  • Most of these studies used fluorescent or non-fluorescent marker genes to track the level and duration of transgene expression in corneal cells.
  • However, limited studies were directed to evaluate prospects of gene-based interventions for corneal diseases or disorders such as allograft rejection, laser-induced post-operative haze, herpes simplex keratitis, and wound healing in animal models.
  • We will review the successes and obstacles impeding gene therapy approaches used for delivering genes into the cornea.
  • [MeSH-major] Corneal Diseases / therapy. Genetic Therapy
  • [MeSH-minor] Animals. Cornea / physiology. Corneal Dystrophies, Hereditary / therapy. Corneal Opacity / therapy. Corneal Transplantation. Genetic Vectors. Graft Survival. Humans. Wound Healing

  • MedlinePlus Health Information. consumer health - Corneal Disorders.
  • MedlinePlus Health Information. consumer health - Genes and Gene Therapy.
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  • (PMID = 15955719.001).
  • [ISSN] 1350-9462
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY10056
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] England
  • [Number-of-references] 167
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90. Pandolfi A, Holzapfel GA: Three-dimensional modeling and computational analysis of the human cornea considering distributed collagen fibril orientations. J Biomech Eng; 2008 Dec;130(6):061006
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three-dimensional modeling and computational analysis of the human cornea considering distributed collagen fibril orientations.
  • A proper interplay between the material structure and the geometry guarantees the refractive function and defines the refractive properties of the cornea.
  • We propose a three-dimensional computational model for the human cornea that is able to provide the refractive power by analyzing the structural mechanical response with the nonlinear regime and the effect the intraocular pressure has.
  • For an assigned unloaded geometry we show how the distribution of the von Mises stress at the top surface of the cornea and through the corneal thickness and the refractive power depend on the material properties and the fibril dispersion.
  • We conclude that a model for the human cornea must not disregard the peculiar collagen fibrillar structure, which equips the cornea with the unique biophysical, mechanical, and optical properties.
  • [MeSH-major] Cornea / physiology. Cornea / ultrastructure. Fibrillar Collagens / physiology. Fibrillar Collagens / ultrastructure. Models, Biological

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  • (PMID = 19045535.001).
  • [ISSN] 0148-0731
  • [Journal-full-title] Journal of biomechanical engineering
  • [ISO-abbreviation] J Biomech Eng
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrillar Collagens
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91. Jirsova K, Neuwirth A, Kalasova S, Vesela V, Merjava S: Mesothelial proteins are expressed in the human cornea. Exp Eye Res; 2010 Nov;91(5):623-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesothelial proteins are expressed in the human cornea.
  • The goal of our study was to determine whether proteins typical of the human mesothelial cell phenotype, such as mesothelin, HBME-1 (Hector Battifora mesothelial cell-1) protein and calbindin 2, are expressed in the human cornea, especially in endothelial cells.
  • A strong signal for mesothelin was present in the corneal epithelium, while less intense staining was visible in the endothelium.
  • Similarly, higher and lower mRNA levels were detected using qRT-PCR in the corneal epithelium and endothelium, respectively.
  • HBME-1 antibody strongly stained the corneal endothelium and stromal keratocytes.
  • Marked positivity was present in the corneal stromal extracellular matrix, while no staining was present in the sclera.
  • Calbindin 2 was detected using immunohistochemistry and Western blotting in the corneal epithelium, endothelium and stroma. qRT-PCR confirmed its expression in epithelial and endothelial cells.
  • Three proteins expressed constitutively in mesothelial cells were detected in the human cornea.
  • The much more pronounced occurrence of calbindin 2 in the corneal epithelium compared to fewer positive endothelial cells explains the higher turnover of epithelial cells compared to the proliferatively inactive endothelium.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Corneal Stroma / metabolism. Endothelium, Corneal / metabolism. Epithelium, Corneal / metabolism. Membrane Glycoproteins / metabolism. S100 Calcium Binding Protein G / metabolism

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20709057.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Eye Proteins; 0 / GPI-Linked Proteins; 0 / HBME-1 antigen; 0 / Membrane Glycoproteins; 0 / RNA, Messenger; 0 / S100 Calcium Binding Protein G; 0 / mesothelin
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92. Rodríguez G, Barbosa-Barros L, Rubio L, Cócera M, Díez A, Estelrich J, Pons R, Caelles J, De la Maza A, López O: Conformational changes in stratum corneum lipids by effect of bicellar systems. Langmuir; 2009 Sep 15;25(18):10595-603

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conformational changes in stratum corneum lipids by effect of bicellar systems.
  • Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy was applied to study the effects of the bicelles formed by dimyristoyl-glycero-phosphocholine (DMPC) and dihexanoyl-glycero-phosphocholine (DHPC) in porcine stratum corneum (SC) in vitro.
  • Bicellar systems caused a phase transition from the gel or solid state to the liquid crystalline state in the lipid conformation of SC, reflecting the major order-disorder transition from hexagonally packed to disordered chains.

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  • (PMID = 19735132.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,2-dihexadecyl-sn-glycero-3-phosphocholine; 0 / Lipids; 0 / Phospholipid Ethers; U86ZGC74V5 / Dimyristoylphosphatidylcholine
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93. Pereira-Pacheco F, Robledo D, Rodríguez-Carvajal L, Freile-Pelegrín Y: Optimization of native agar extraction from Hydropuntia cornea from Yucatán, México. Bioresour Technol; 2007 Apr;98(6):1278-84
Hazardous Substances Data Bank. AGAR-AGAR .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optimization of native agar extraction from Hydropuntia cornea from Yucatán, México.
  • Response surface methodology (RSM) was used to determine optimum extraction conditions for yield, gelling temperature, melting temperature and apparent viscosity of native agar from the red alga Hydropuntia cornea.
  • Most of the physicochemical properties found in the native agar from H. cornea extracted at 100 degrees C/3 h were similar to commercial samples.

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  • (PMID = 16797974.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9002-18-0 / Agar
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94. Graglia F, Mari JL, Baïkoff G, Sequeira J: Contour detection of the cornea from OCT radial images. Conf Proc IEEE Eng Med Biol Soc; 2007;2007:5612-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contour detection of the cornea from OCT radial images.
  • In this paper, we present a new approach for contour detection in the frame of OCT images of the cornea.
  • With the aim of detecting upper and lower curves that define the cornea in radial slices, we have elaborated a three step specific method.
  • In the final step both anchor points are used as starting points for the algorithm: we trace the contour of the cornea pixel by pixel from these two points with a weight criterion.
  • Taking into account geometrical knowledge of the cornea enhances the robustness of the technique.
  • [MeSH-major] Artificial Intelligence. Cornea / anatomy & histology. Corneal Topography / methods. Image Interpretation, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Pattern Recognition, Automated / methods. Tomography, Optical Coherence / methods

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  • (PMID = 18003285.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Hao J, Li SK, Kao WW, Liu CY: Gene delivery to cornea. Brain Res Bull; 2010 Feb 15;81(2-3):256-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene delivery to cornea.
  • This paper reviews the strategies of in vivo gene delivery to the cornea.
  • A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.
  • The introduction of foreign genes into intact corneal epithelium specifically requires more invasive procedures such as gene gun to disrupt the tight junction barrier and/or cell membranes.
  • The combination of iontophoresis and electroporation was found to be effective in delivering siRNA but not plasmid DNA into the corneal epithelium.
  • Nanocarriers such as polymeric micelles are promising methods of corneal gene delivery.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
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  • (PMID = 19560524.001).
  • [ISSN] 1873-2747
  • [Journal-full-title] Brain research bulletin
  • [ISO-abbreviation] Brain Res. Bull.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY15181; United States / NEI NIH HHS / EY / R01 EY015181; United States / NEI NIH HHS / EY / EY11845; United States / NEI NIH HHS / EY / R01 EY010556-09; United States / NEI NIH HHS / EY / R01 EY011845-07; United States / NEI NIH HHS / EY / R01 EY013755-07; United States / NEI NIH HHS / EY / EY010556-09; United States / NEI NIH HHS / EY / R01 EY010556; United States / NEI NIH HHS / EY / R01 EY013755; United States / NEI NIH HHS / EY / EY011845-07; United States / NEI NIH HHS / EY / R01 EY015181-05; United States / NEI NIH HHS / EY / EY013755-07; United States / NEI NIH HHS / EY / R01 EY011845; United States / NEI NIH HHS / EY / EY10556
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
  • [Other-IDs] NLM/ NIHMS128071; NLM/ PMC2823390
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96. Ruffien-Ciszak A, Gros P, Comtat M, Schmitt AM, Questel E, Casas C, Redoules D: Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry. J Pharm Biomed Anal; 2006 Jan 23;40(1):162-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry.
  • This method ensured a direct, rapid (less than 1 min), reliable (accuracy 12%) and non-invasive measurement of the global antioxidant capacity of the stratum corneum with a high spatiotemporal resolution.

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  • (PMID = 16137853.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Free Radical Scavengers; 0 / Reactive Oxygen Species; PQ6CK8PD0R / Ascorbic Acid
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97. Tomita Y, Akiyama M, Shimizu H: Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis. Exp Dermatol; 2005 Aug;14(8):619-24
Genetic Alliance. consumer health - Ichthyosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis.
  • To determine any correlation between the stratum corneum barrier function and the phenotypic severity of congenital ichthyosis, we studied stratum corneum hydration, flexibility, thickness and transepidermal water loss (TEWL) in patients with congenital ichthyosis.
  • Stratum corneum hydration, thickness and flexibility were measured using a Corneometer ASA-M2.
  • The stratum corneum thickness was also examined using a skin biopsy technique.
  • Stratum corneum hydration and flexibility were significantly reduced in both congenital ichthyosis patient groups.
  • Stratum corneum thickness was significantly increased in both groups.
  • In the patient group with non-bullous congenital ichthyosis, significant negative correlations were confirmed between the VAS score and stratum corneum hydration and between the VAS score and flexibility.
  • A significant, positive correlation was also observed between the VAS score and stratum corneum thickness.
  • We conclude that stratum corneum hydration, flexibility and thickness measured by the corneometer, and TEWL on the arm may be a useful indicator of the severity of ichthyosis phenotype.
  • [MeSH-major] Epidermis / physiology. Hyperkeratosis, Epidermolytic / diagnosis. Ichthyosis / diagnosis. Ichthyosis / pathology. Ichthyosis, Lamellar / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Phenotype. Skin / pathology. Skin Absorption. Skin Diseases / diagnosis. Skin Physiological Phenomena

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  • (PMID = 16026584.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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98. Morishige N, Ko JA, Liu Y, Chikama T, Nishida T: Localization of semaphorin 3A in the rat cornea. Exp Eye Res; 2008 Apr;86(4):669-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localization of semaphorin 3A in the rat cornea.
  • We investigated the localization of Sema3A in the cornea, one of the most sensitive tissues in the body.
  • Immunoblot analysis and reverse transcription-polymerase chain reaction analysis revealed that Sema3A protein and mRNA are expressed in the normal rat cornea.
  • Immunofluorescence staining of frozen sections or tissue blocks prepared from the cornea revealed the presence of Sema3A in wing cells and basal cells (but not superficial cells) of the corneal epithelium, in keratocytes, and in the corneal endothelium.
  • The expression pattern of Sema3A in the corneal epithelium differed from those of zonula occludens-1 and connexin43.
  • These observations show that Sema3A is expressed in all cells of the rat cornea with the exception of superficial epithelial cells.
  • [MeSH-major] Cornea / metabolism. Eye Proteins / metabolism. Semaphorin-3A / metabolism
  • [MeSH-minor] Animals. Endothelium, Corneal / metabolism. Epithelium, Corneal / metabolism. Gene Expression. RNA, Messenger / genetics. Rats. Rats, Wistar. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 18308303.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / RNA, Messenger; 0 / Sema3a protein, rat; 0 / Semaphorin-3A
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99. Rim JE, Pinsky PM, van Osdol WW: Using the method of homogenization to calculate the effective diffusivity of the stratum corneum with permeable corneocytes. J Biomech; 2008;41(4):788-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Using the method of homogenization to calculate the effective diffusivity of the stratum corneum with permeable corneocytes.
  • The stratum corneum is the outermost layer of the skin, which acts as a barrier membrane against the penetration of molecules into and out of the body.
  • The macroscopic transport properties of the stratum corneum are functions of its microstructure and the transport properties of the corneocytes and the lipid matrix, and are of considerable interest in the context of transdermal drug delivery and quantifying exposure to toxins, as well as for determining the relation of skin disorders to disruption of the stratum corneum barrier.
  • Due to the complexity of the tissue and the difference in length scales involved in its microstructure, a direct analysis of the mass transport properties of the stratum corneum is not feasible.
  • In this study, we undertake an approach where the macroscopic diffusion tensor of the stratum corneum is obtained through homogenization using the method of asymptotic expansions.
  • The biphasic structure of the stratum corneum is fully accounted for by allowing the corneocytes to be permeable and considering the partitioning between the corneocytes and the lipid phases.
  • By systematically exploring the effect of permeable corneocytes on the macroscopic transport properties of the stratum corneum, we show that solute properties such as lipophilicity and relative permeabilities in the two phases have large effects on its transdermal diffusion behavior.

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  • (PMID = 18093598.001).
  • [ISSN] 0021-9290
  • [Journal-full-title] Journal of biomechanics
  • [ISO-abbreviation] J Biomech
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Haque S, Jones L, Simpson T: Thickness mapping of the cornea and epithelium using optical coherence tomography. Optom Vis Sci; 2008 Oct;85(10):E963-76
MedlinePlus Health Information. consumer health - Eye Wear.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thickness mapping of the cornea and epithelium using optical coherence tomography.
  • PURPOSE: To measure corneal and epithelial thickness across four meridians using Optical Coherence Tomography (OCT) and to compare these measurements between normal non-lens wearers (NLW), rigid gas permeable (RGP) lens wearers, and RGP-wearing keratoconics (KC).
  • A customized fixation target employing LEDs in eight directions of gaze was attached to the OCT and corneal images obtained.
  • Raw OCT scans were analyzed to yield values for corneal and epithelial thickness and color-coded maps were compiled.
  • RESULTS: Central corneal thickness (CCT) was thinnest in KC (447 +/- 68 microm) and similar between RGP (518 +/- 32 microm; pKC < 0.001) and NLW (517 +/- 21 microm) (p(KC) < 0.001 NLW pRGP > 0.05).
  • Peripheral corneal thickness in NLW was thickest in the superior temporal and thinnest in the inferior (I) regions (superior temporal(thickest) vs. I(thinnest) p < 0.001).
  • CONCLUSIONS: Thickness of the normal cornea and epithelium was greatest in the superior region.
  • In all groups, the inferior cornea and epithelium was thinnest, and to a greater extent in the KC group.
  • [MeSH-major] Contact Lenses. Cornea / pathology. Corneal Topography / methods. Epithelium, Corneal / pathology. Keratoconus / pathology. Tomography, Optical Coherence
  • [MeSH-minor] Adult. Corneal Stroma / pathology. Equipment Design. Female. Humans. Male. Young Adult

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  • (PMID = 18832971.001).
  • [ISSN] 1538-9235
  • [Journal-full-title] Optometry and vision science : official publication of the American Academy of Optometry
  • [ISO-abbreviation] Optom Vis Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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