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1. Ito H, Akiyama M, Nakagawa H, Uematsu R, Deguchi K, McMillan JR, Nishimura S, Shimizu H: N-linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin. Arch Dermatol Res; 2007 Jan;298(8):403-7
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  • [Title] N-linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin.
  • However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail.
  • To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients.

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  • (PMID = 17021764.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Oligosaccharides; 0 / Polysaccharides
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2. Iwai I, Shimadzu K, Kobayashi Y, Hirao T, Etou T: Increased carbonyl protein level in the stratum corneum of inflammatory skin disorders: A non-invasive approach. J Dermatol; 2010 Aug;37(8):693-8
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  • [Title] Increased carbonyl protein level in the stratum corneum of inflammatory skin disorders: A non-invasive approach.
  • The stratum corneum (SC) is the interface of body and environment, and is continuously exposed to oxidative stress, resulting in carbonyl modification of proteins.
  • We have developed a simple and non-invasive method to assess carbonyl protein (CP) level in the SC, applied it to various kinds of skin, and revealed a link between the stratum corneum carbonylated protein (SCCP) level and water content in the SC.
  • Psoriasis vulgaris (PV) and atopic dermatitis (AD) are typical inflammatory skin disorders, of which the stratum corneum shows markedly low water content.

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  • (PMID = 20649709.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Wong R, Tran V, Talwalker S, Benson NR: Analysis of RNA recovery and gene expression in the epidermis using non-invasive tape stripping. J Dermatol Sci; 2006 Nov;44(2):81-92
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  • We hypothesize that RNA recovered by tape strip is not derived from corneocytes but from cells associated with the stratum corneum.
  • [MeSH-minor] Abdomen. Adolescent. Adult. Back. Extremities. Female. Forehead. Humans. Interleukin-8 / genetics. Interleukin-8 / metabolism. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Specimen Handling. Tumor Necrosis Factor-alpha / genetics. Tumor Necrosis Factor-alpha / metabolism. Water Loss, Insensible

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  • (PMID = 17014996.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adhesives; 0 / Interleukin-8; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 63231-63-0 / RNA
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4. Gagna CE, Chan NJ, Farnsworth PN, Kuo HR, Kanthala TR, Patel AH, Patel NH, Law A, Patel PP, Richards SA, Yam T, Nici A, Lambert WC: Localization and quantification of intact, undamaged right-handed double-stranded B-DNA, and denatured single-stranded DNA in normal human epidermis and its effects on apoptosis and terminal differentiation (denucleation). Arch Dermatol Res; 2009 Oct;301(9):659-72
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  • In addition, we examined the precise starting point of cell death within the epidermis (suprabasal layer); examined how DNA structure affects gene expression of melanocytes; and characterized the "transitional cells" located between the stratum granulosum and stratum corneum, viz., epidermal phase transition zone (EPTZ).

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  • (PMID = 19517127.001).
  • [ISSN] 1432-069X
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Single-Stranded
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5. Pellanda C, Ottiker E, Strub C, Figueiredo V, Rufli T, Imanidis G, Surber C: Topical bioavailability of triamcinolone acetonide: effect of dose and application frequency. Arch Dermatol Res; 2006 Oct;298(5):221-30
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  • The aim of the study was to investigate the effect of dose (Experiment 1) and application frequency (Experiment 2) on the penetration of triamcinolone acetonide (TACA) into human stratum corneum (SC) in vivo.

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  • (PMID = 16858572.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adhesives; 0 / Glucocorticoids; F446C597KA / Triamcinolone Acetonide
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6. Parish WE, Read J, Paterson SE: Changes in basal cell mitosis and transepidermal water loss in skin cultures treated with vitamins C and E. Exp Dermatol; 2005 Sep;14(9):684-91
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  • Incubation in 60% RH was achieved using a novel chamber and dishes exposing only the corneum, sealing the medium.

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  • (PMID = 16098128.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Culture Media; 1406-18-4 / Vitamin E; PQ6CK8PD0R / Ascorbic Acid
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7. Larese FF, D'Agostin F, Crosera M, Adami G, Renzi N, Bovenzi M, Maina G: Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicology; 2009 Jan 8;255(1-2):33-7
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  • Moreover, silver nanoparticles could be detected in the stratum corneum and the outermost surface of the epidermis by electron microscopy.

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  • (PMID = 18973786.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Indicators and Reagents; 3M4G523W1G / Silver
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8. Badiee P, Nejabat M, Alborzi A, Keshavarz F, Shakiba E: Comparative study of Gram stain, potassium hydroxide smear, culture and nested PCR in the diagnosis of fungal keratitis. Ophthalmic Res; 2010;44(4):251-6
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  • [Title] Comparative study of Gram stain, potassium hydroxide smear, culture and nested PCR in the diagnosis of fungal keratitis.
  • METHODS: Patients with eye findings suspected of FK were enrolled for cornea sampling.
  • [MeSH-major] Bacteriological Techniques. Corneal Ulcer / diagnosis. Eye Infections, Fungal / diagnosis. Fungi / cytology. Fungi / genetics. Gentian Violet. Phenazines. Polymerase Chain Reaction

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20699629.001).
  • [ISSN] 1423-0259
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA, Fungal; 0 / Gram's stain; 0 / Hydroxides; 0 / Phenazines; 0 / Potassium Compounds; J4Z741D6O5 / Gentian Violet; WZH3C48M4T / potassium hydroxide
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9. Raj D, Brash DE, Grossman D: Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol; 2006 Feb;126(2):243-57
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  • Apoptosis balances proliferation to maintain epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignant cells.

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  • (PMID = 16418733.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R01 AR050102-03; United States / NIAMS NIH HHS / AR / K08 AR048618; United States / NIAMS NIH HHS / AR / AR048953-03; United States / NIAMS NIH HHS / AR / R03 AR048953-03; United States / NIAMS NIH HHS / AR / R01 AR050102; United States / NIAMS NIH HHS / AR / K08 AR48618; United States / NIAMS NIH HHS / AR / AR050102-03; United States / NIAMS NIH HHS / AR / R03 AR048953
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 135
  • [Other-IDs] NLM/ NIHMS44279; NLM/ PMC2291295
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10. Ben-Shlomo G, Plummer C, Barrie K, Brooks D: Curvularia keratomycosis in a dog. Vet Ophthalmol; 2010 Mar;13(2):126-30
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  • Ophthalmic examination revealed a 3-4 mm diameter corneal ulcer with faint edema at the lesion edge, and a raised grayish area on the paraxial cornea near the 2 o'clock position.
  • After 8 days of medical therapy, an improvement of clinical signs was noted, and 15 days after initiation of treatment, the ulcer was healed with minimal corneal scarring.

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  • [CommentIn] Vet Ophthalmol. 2010 Jul;13(4):278; author reply 278 [20618810.001]
  • (PMID = 20447033.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Wei LC, Tsai TC, Tsai HY, Wang CY, Shen YC: Comparison of voriconazole concentration in the aqueous humor and vitreous between non-scraped and scraped corneal epithelium groups after topical 1% voriconazole application. Curr Eye Res; 2010 Jul;35(7):573-9
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  • [Title] Comparison of voriconazole concentration in the aqueous humor and vitreous between non-scraped and scraped corneal epithelium groups after topical 1% voriconazole application.
  • PURPOSE: To investigate the penetration of topical 1% voriconazole through the cornea into the aqueous humor in New Zealand white rabbits and to determine the effect of mechanical scraping of the corneal epithelium.
  • MATERIALS AND METHODS: The right eyes of 29 New Zealand white rabbits were maintained with the epithelium intact, and the left eyes underwent mechanical epithelium debridement of the central 7.5 mm of the cornea.
  • [MeSH-major] Antifungal Agents / pharmacokinetics. Aqueous Humor / metabolism. Debridement. Epithelium, Corneal / metabolism. Pyrimidines / pharmacokinetics. Triazoles / pharmacokinetics. Vitreous Body / metabolism

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  • (PMID = 20597643.001).
  • [ISSN] 1460-2202
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Ophthalmic Solutions; 0 / Pyrimidines; 0 / Triazoles; JFU09I87TR / Voriconazole
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12. Blaise G, Nikkels AF, Hermanns-Lê T, Nikkels-Tassoudji N, Piérard GE: Corynebacterium-associated skin infections. Int J Dermatol; 2008 Sep;47(9):884-90
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  • BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum.
  • MATERIALS AND METHODS: A 2-year, two-center, prospective survey assessed the demographics of pitted keratolysis, including age, gender, site of infection, symptoms, patients' complaints, the use of protective and/or occlusive shoes, seasonality of diagnosis, drug intake, associated skin signs (including dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous diagnoses and treatments.
  • [MeSH-major] Corynebacterium / isolation & purification. Corynebacterium Infections / diagnosis. Skin Diseases, Bacterial / diagnosis

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  • (PMID = 18937649.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 52
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13. Xie JL, Li TZ, Qi SH, Huang B, Chen XG, Chen JD: A study of using tissue-engineered skin reconstructed by candidate epidermal stem cells to cover the nude mice with full-thickness skin defect. J Plast Reconstr Aesthet Surg; 2007;60(9):983-90
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  • RESULTS: The transplanted skin developed a well-differentiated epidermis composed of stratum basale, prickle cell layer, granular layer and stratum corneum and clearly defined dermis with the morphological features of intact skin.

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  • (PMID = 17662463.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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14. Tate M, Grove G, Joch R, Laabs J, Menard K, Nelson B, Shepard K, Zepp R, Zerweck C, Zuleger R: Dye exclusion as a means to measure wetness protection of human skin. Skin Res Technol; 2007 Aug;13(3):293-8
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  • Damage to the stratum corneum occurs from prolonged exposure to wetness and limited product breathability, which reduces evaporation.
  • [MeSH-major] Coloring Agents. Diaper Rash / diagnosis. Diapers, Infant / adverse effects. Epidermis / metabolism. Water / metabolism

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  • (PMID = 17610651.001).
  • [ISSN] 0909-752X
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Ointments; 059QF0KO0R / Water
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15. Akita S, Akino K, Imaizumi T, Tanaka K, Anraku K, Yano H, Hirano A: A polyurethane dressing is beneficial for split-thickness skin-graft donor wound healing. Burns; 2006 Jun;32(4):447-51
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  • We examined their clinical usefulness such as accelerated healing time, frequency of changing the dressing, degree of pain, or amount of exudates, and performed moisture meter analysis at 1 month and 1 year after re-epithelialization, which reflects the quality of the stratum corneum and subsequent scarring.

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  • (PMID = 16621321.001).
  • [ISSN] 0305-4179
  • [Journal-full-title] Burns : journal of the International Society for Burn Injuries
  • [ISO-abbreviation] Burns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Polyurethanes
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16. Sosne G, Qiu P, Kurpakus-Wheater M: Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clin Ophthalmol; 2007 Sep;1(3):201-7
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  • [Title] Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent.
  • In cornea, as in other tissues, Tbeta(4) promotes cell migration and wound healing, has anti-inflammatory properties, and suppresses apoptosis.
  • In this review we discuss the current state of knowledge regarding the effects of Tbeta(4) in maintaining the healthy, functional cornea.

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  • (PMID = 19668473.001).
  • [ISSN] 1177-5467
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2701135
  • [Keywords] NOTNLM ; apoptosis / cell migration / cornea / inflammation / thymosin beta 4 / wound healing
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17. Sahu SK, Das S, Sharma S, Vemuganti GK: Acanthamoeba keratitis presenting as a plaque. Cornea; 2008 Oct;27(9):1066-7
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  • METHODS: A 55-year-old woman presented with a yellow plaque-like lesion on the cornea surrounded by an infiltrate.
  • CONCLUSIONS: Acanthamoeba infection of cornea may present as a plaque-like lesion.
  • [MeSH-major] Acanthamoeba Keratitis / pathology. Cornea / pathology
  • [MeSH-minor] Atropine / administration & dosage. Atropine / therapeutic use. Biguanides / administration & dosage. Biguanides / therapeutic use. Ciprofloxacin / administration & dosage. Ciprofloxacin / therapeutic use. Diagnosis, Differential. Drug Administration Schedule. Drug Therapy, Combination. Eye Infections, Fungal / diagnosis. Female. Humans. Middle Aged. Ophthalmic Solutions

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  • (PMID = 18812773.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biguanides; 0 / Ophthalmic Solutions; 28757-47-3 / polyhexamethylene biguanide; 5E8K9I0O4U / Ciprofloxacin; 7C0697DR9I / Atropine
  • [Number-of-references] 8
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18. Tobey NA, Djukic Z, Brighton LE, Gambling TM, Carson JL, Orlando RC: Lateral cell membranes and shunt resistance in rabbit esophageal epithelium. Dig Dis Sci; 2010 Jul;55(7):1856-65
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  • BACKGROUND AND AIMS: The structures that contribute to shunt resistance (Rs) in esophageal epithelium are incompletely understood, with 35-40% of Rs known to be calcium-dependent, reflecting the role of e-cadherin.
  • Two calcium-independent candidates for the remaining approximately 60% of Rs have been identified: the glycoprotein matrix (GPM) within stratum corneum of esophageal epithelium, and the lateral cell membranes (LCMs) from neighboring cells.
  • That urea reduced R(T), and so Rs, by widening the intercellular spaces, and not by altering the e-cadherin-dependent apical junctional complex, was supported by the ability of: (a) calcium-free solution to reduce R(T) beyond that produced by urea, (b) hypertonic urea to reduce R(T) beyond that produced by calcium free solution, (c) hypertonic sucrose to collapse the intercellular spaces and raise R(T), and (d) empigen, a zwitterionic detergent, to non-osmotically widen the intercellular spaces and reduce R(T).

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  • (PMID = 20503073.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 5R37-DK036013; United States / NIDDK NIH HHS / DK / DK063669
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Hypertonic Solutions; 57-50-1 / Sucrose; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.- / Hexosaminidases; EC 3.2.1.18 / Neuraminidase; EC 3.2.1.97 / glycopeptide alpha-N-acetylgalactosaminidase
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19. Boury-Jamot M, Sougrat R, Tailhardat M, Le Varlet B, Bonté F, Dumas M, Verbavatz JM: Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? Biochim Biophys Acta; 2006 Aug;1758(8):1034-42
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  • Skin is the limiting tissue of the body and within skin, the stratum corneum (SC) of the epidermis is the limiting barrier to water loss by evaporation.

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  • (PMID = 16872579.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / AQP3 protein, human; 0 / Aquaporins; 158801-98-0 / Aquaporin 3; PDC6A3C0OX / Glycerol
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20. Sheu MT, Wu AB, Lin KP, Shen CH, Ho HO: Effect of tocopheryl polyethylene glycol succinate on the percutaneous penetration of minoxidil from water/ethanol/polyethylene glycol 400 solutions. Drug Dev Ind Pharm; 2006 Jun;32(5):595-607
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  • Tocopheryl polyethylene glycol succinate (TPGS) was mainly retained locally in the stratum corneum, and the amount was proportional to the increase in the amount of TPGS added to these ten solvent formulations.

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  • (PMID = 16720414.001).
  • [ISSN] 0363-9045
  • [Journal-full-title] Drug development and industrial pharmacy
  • [ISO-abbreviation] Drug Dev Ind Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Solutions; 0 / Surface-Active Agents; 0 / Vasodilator Agents; 059QF0KO0R / Water; 1406-18-4 / Vitamin E; 30IQX730WE / Polyethylene Glycols; 3K9958V90M / Ethanol; 5965120SH1 / Minoxidil; 9002-96-4 / alpha-tocopheryl polyethylene glycol succinate
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21. Gonzalez Maglio DH, Paz ML, Ferrari A, Weill FS, Czerniczyniec A, Leoni J, Bustamante J: Skin damage and mitochondrial dysfunction after acute ultraviolet B irradiation: relationship with nitric oxide production. Photodermatol Photoimmunol Photomed; 2005 Dec;21(6):311-7
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  • RESULTS: Morphological analysis showed disruption of the epidermal stratum corneum and basale after UVB irradiation.

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  • (PMID = 16313242.001).
  • [ISSN] 0905-4383
  • [Journal-full-title] Photodermatology, photoimmunology & photomedicine
  • [ISO-abbreviation] Photodermatol Photoimmunol Photomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 11062-77-4 / Superoxides; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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22. Talarico EF Jr, Kennedy BG, Marfurt CF, Loeffler KU, Mangini NJ: Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium. Mol Vis; 2005 Mar 2;11:169-78
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  • [Title] Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium.
  • Little is known about the expression of these isoforms in corneal epithelium (CE).
  • PMCA2 IR was detected cytoplasmically within basal and wing cells in both central cornea and limbus.
  • PMCA3 IR was located in basal cell nuclei in central cornea, but in a perinuclear location in the limbal, basal, and wing cells.
  • [MeSH-major] Calcium-Transporting ATPases / genetics. Cation Transport Proteins / genetics. Epithelium, Corneal / enzymology. Gene Expression Regulation, Enzymologic

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  • (PMID = 15765049.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R0I EY11308
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cation Transport Proteins; 0 / Isoenzymes; 0 / RNA, Messenger; EC 3.6.3.8 / ATP2B1 protein, human; EC 3.6.3.8 / ATP2B2 protein, human; EC 3.6.3.8 / ATP2B3 protein, human; EC 3.6.3.8 / Calcium-Transporting ATPases; EC 3.6.3.8 / Plasma Membrane Calcium-Transporting ATPases; SY7Q814VUP / Calcium
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23. Rahman I, Cannon PS, Sadiq SA: Tonopen versus Goldmann applanation tonometry for detecting restrictive thyroid eye disease. Ophthal Plast Reconstr Surg; 2010 Jan-Feb;26(1):36-8
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  • The aim of this study was to assess whether the IOP when measured with the eyes in upgaze (the Goldmann applanation tonometer [GAT] head applanating the inferior/peripheral cornea) is similar when compared with the central corneal IOP in upgaze using the Tono-Pen XL.
  • METHODS: IOP was measured with the GAT on the central cornea in primary gaze and on the inferior cornea in upgaze.
  • IOP was measured with the Tono-Pen XL in the central cornea in both primary gaze and upgaze.
  • [MeSH-major] Graves Ophthalmopathy / diagnosis. Intraocular Pressure. Ocular Motility Disorders / diagnosis. Oculomotor Muscles / pathology. Tonometry, Ocular / instrumentation

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  • (PMID = 20090483.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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24. Lascaratos G, Gupta M, Bridges L, MacRae M: Myofibroma of the conjunctiva invading the cornea in infancy. J Pediatr Ophthalmol Strabismus; 2010;47 Online:e1-3
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  • [Title] Myofibroma of the conjunctiva invading the cornea in infancy.
  • To the authors' knowledge, this is the first reported case of myofibroma originating from the conjunctiva and this case highlights the importance of considering myofibromatosis in the differential diagnosis of unusual conjunctival lesions.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Cornea / pathology. Myofibroma / pathology
  • [MeSH-minor] Actins / analysis. Biomarkers, Tumor / analysis. Female. Humans. Infant. Neoplasm Invasiveness. Vimentin / analysis

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21214145.001).
  • [ISSN] 1938-2405
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Vimentin
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25. Suh LH, Yoo SH, Deobhakta A, Donaldson KE, Alfonso EC, Culbertson WW, O'Brien TP: Complications of Descemet's stripping with automated endothelial keratoplasty: survey of 118 eyes at One Institute. Ophthalmology; 2008 Sep;115(9):1517-24
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  • PURPOSE: To compile a survey of complications during and after Descemet's stripping with automated endothelial keratoplasty (DSAEK) in 118 eyes conducted by cornea subspecialists at a single academic center.
  • Detached DSAEK grafts were repositioned, rebubbled, or both immediately after diagnosis of this complication.
  • In 17 eyes, successful reattachment of the cornea occurred (68%).
  • CONCLUSIONS: Descemet's stripping with automated endothelial keratoplasty has become a popular and effective treatment for corneal endothelial dysfunction, but complications resulting from DSAEK do occur.
  • [MeSH-major] Corneal Transplantation. Descemet Membrane / surgery. Endothelium, Corneal / transplantation. Intraoperative Complications. Postoperative Complications
  • [MeSH-minor] Anterior Chamber / pathology. Corneal Diseases / surgery. Female. Graft Survival. Health Surveys. Humans. Lens Implantation, Intraocular. Male. Phacoemulsification. Retrospective Studies. Silicone Oils / administration & dosage. Sulfur Hexafluoride / administration & dosage. Tomography, Optical Coherence

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  • (PMID = 18378315.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Silicone Oils; WS7LR3I1D6 / Sulfur Hexafluoride
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26. Bilgihan K, Ozdek SC, Sari A, Hasanreisoğlu B: Excimer laser-assisted anterior lamellar keratoplasty for keratoconus, corneal problems after laser in situ keratomileusis, and corneal stromal opacities. J Cataract Refract Surg; 2006 Aug;32(8):1264-9
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  • [Title] Excimer laser-assisted anterior lamellar keratoplasty for keratoconus, corneal problems after laser in situ keratomileusis, and corneal stromal opacities.
  • PURPOSE: To evaluate excimer laser-assisted anterior lamellar keratoplasty to augment thin corneas as in keratoconus (<350 microm) and corneal ectasia after laser in situ keratomileusis (LASIK) and to treat anterior stromal opacities.
  • The treatment group was divided into corneal ectasia and stromal opacity groups.
  • The remaining cornea (epithelium, Bowman's membrane, and stroma) was punched with a 7.5 or 7.7 mm trephine.
  • After transepithelial ablation of the host cornea to 200 mum thickness, the corneal button was sutured with interrupted 10-0 monofilament nylon.
  • Preoperative and postoperative simulated keratometric cylinders and corneal thickness values were compared using the Wilcoxon signed rank test.
  • The mean corneal thickness was 381.2 +/- 88.2 microm preoperatively, which significantly increased to 534.9 +/- 96.6 microm postoperatively (P < .05).
  • CONCLUSIONS: This technique presents a different modality for the treatment of keratoconus, post-LASIK corneal problems, and other corneal stromal opacities with anterior lamellar keratoplasty.
  • [MeSH-major] Corneal Opacity / surgery. Corneal Stroma / surgery. Corneal Transplantation / methods. Keratoconus / surgery. Keratomileusis, Laser In Situ / adverse effects. Laser Therapy / methods
  • [MeSH-minor] Adult. Child. Corneal Diseases / etiology. Corneal Diseases / surgery. Dilatation, Pathologic / etiology. Dilatation, Pathologic / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications. Refraction, Ocular. Visual Acuity

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  • (PMID = 16863959.001).
  • [ISSN] 0886-3350
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Robertson DM, Ladage PM, Yamamoto N, Jester JV, Petroll WM, Cavanagh HD: Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice. Eye Contact Lens; 2006 Jan;32(1):3-7
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  • [Title] Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice.
  • PURPOSE: The antiapoptotic protein Bcl-2 and its proapoptotic counterpart Bax may play an important role in the regulation of corneal epithelial renewal.
  • To understand the physiologic importance of Bcl-2 and Bax in the healthy cornea, epithelial and stromal thickness, proliferation, and surface cell exfoliation rates were examined in the central cornea of genetically altered mice overexpressing Bcl-2 and lacking Bax.
  • Corneal epithelial renewal was examined by in vivo tandem scanning confocal microscopy to measure total corneal and sublayer thickness and by immunohistochemistry on whole mount corneal tissues to determine basal epithelial cell proliferation using 5-bromo-2-deoxyuridine (BrdU) and surface cell exfoliation with a Calcein AM-Ethidium homodimer assay (live/dead).
  • Western blotting confirmed that there was no change in the level of Bcl-2 expression in the corneal epithelium in the Bcl-2 transgenic or Bax knockout strains.
  • CONCLUSIONS: The significant difference in epithelial and stromal thickness suggests a functional role for Bcl-2 and Bax in the maintenance of corneal homeostasis; however, the lack of significant alterations in proliferation, cell exfoliation, and levels of Bcl-2 protein in the adult corneal epithelium suggest that these phenotypic changes are a result of a new stable homeostatic equilibrium (proliferation + migration = shedding).
  • Additional experiments to delineate the role of Bcl-2 and Bax during development and in the adult cornea are necessary.
  • [MeSH-major] Cornea / physiology. Gene Expression Regulation. Genes, bcl-2 / genetics. Homeostasis / genetics. bcl-2-Associated X Protein / genetics

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  • (PMID = 16415685.001).
  • [ISSN] 1542-2321
  • [Journal-full-title] Eye & contact lens
  • [ISO-abbreviation] Eye Contact Lens
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-10738
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bax protein, mouse; 0 / bcl-2-Associated X Protein
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28. Filoni S: Retina and lens regeneration in anuran amphibians. Semin Cell Dev Biol; 2009 Jul;20(5):528-34
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  • By contrast, the regeneration of the lens has been demonstrated only in larvae of species belonging to the Xenopus genus, where the lens regenerates through transdifferentiation of the outer cornea.
  • Retinal pigmented epithelium to neural retina and outer cornea to lens transdifferentiation processes are triggered and sustained by signaling molecules belonging to the family of the fibroblast growth factor.

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  • (PMID = 19095070.001).
  • [ISSN] 1096-3634
  • [Journal-full-title] Seminars in cell & developmental biology
  • [ISO-abbreviation] Semin. Cell Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 82
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29. Saika S, Yamanaka O, Sumioka T, Okada Y, Miyamoto T, Shirai K, Kitano A, Tanaka S: Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea. Eye Contact Lens; 2010 Sep;36(5):286-9
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  • [Title] Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea.
  • Maintenance of the transparency and regular shape of the cornea are essential to the normal vision, whereas opacification of the tissue impairs vision.
  • Fibrogenic reaction leading to scarring in an injured cornea is characterized by appearance of myofibroblasts, the key player of the fibrogenic reaction, and excess accumulation of fibrous extracellular matrix.
  • Modulation of transforming growth factor beta signal transduction molecules, e.g., Smad and mitogen-activated protein kinases, by gene transfer and other technology provides a new concept of prevention/treatment of unfavorable fibrogenesis in the cornea.
  • [MeSH-major] Cornea / physiology. Cornea / physiopathology. Corneal Diseases / prevention & control. Corneal Diseases / therapy. Signal Transduction / physiology. Transforming Growth Factor beta / metabolism
  • [MeSH-minor] Cell Transdifferentiation. Endothelium, Corneal / pathology. Fibrosis. Gene Transfer Techniques. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mitogen-Activated Protein Kinases / genetics. Myofibroblasts / pathology. Smad Proteins / genetics. Wound Healing

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  • (PMID = 20823707.001).
  • [ISSN] 1542-233X
  • [Journal-full-title] Eye & contact lens
  • [ISO-abbreviation] Eye Contact Lens
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Smad Proteins; 0 / Transforming Growth Factor beta; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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30. Wiechers JW, Musee N: Engineered inorganic nanoparticles and cosmetics: facts, issues, knowledge gaps and challenges. J Biomed Nanotechnol; 2010 Oct;6(5):408-31
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  • Data indicates that although particular types of ENPs can penetrate into the skin, until now no penetration has been detected beyond the stratum corneum of the ENPs used in cosmetics.

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  • (PMID = 21329039.001).
  • [ISSN] 1550-7033
  • [Journal-full-title] Journal of biomedical nanotechnology
  • [ISO-abbreviation] J Biomed Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Inorganic Chemicals
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31. Primo FL, Bentley MV, Tedesco AC: Photophysical studies and in vitro skin permeation/retention of Foscan/nanoemulsion (NE) applicable to photodynamic therapy skin cancer treatment. J Nanosci Nanotechnol; 2008 Jan;8(1):340-7
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  • After topical application in a skin animal model, we evaluated the Foscan/NE diffusion flux into the skin layers (stratum corneum and epidermis + dermis) by classical procedures using Franz Diffusion cells.

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  • (PMID = 18468080.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Emulsions; 0 / Mesoporphyrins; 0 / Photosensitizing Agents; FU21S769PF / temoporfin
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32. Wakashin K: Sanitary napkin contact dermatitis of the vulva: location-dependent differences in skin surface conditions may play a role in negative patch test results. J Dermatol; 2007 Dec;34(12):834-7
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  • Resistance of the skin against external irritant stimuli is variable among different body sites and the genital skin, which is covered by thin stratum corneum, is thought to have low resistance against various external irritating and mechanical stimuli induced by wearing a sanitary napkin.
  • [MeSH-major] Dermatitis, Contact / diagnosis. Dermatitis, Contact / etiology. Menstrual Hygiene Products / adverse effects. Patch Tests. Vulva

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  • (PMID = 18078410.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. Poindexter BJ: Immunofluorescence deconvolution microscopy and image reconstruction of human defensins in normal and burned skin. J Burns Wounds; 2005;4:e7
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  • In normal skin, human beta defensin-1 was localized to the perinuclear region of keratinocytes; human beta defensin-2 was primarily localized to the stratum germinativum; human beta defensin-3 was found in dendritic cells of the stratum spinosum; human neutrophil peptide was randomly distributed in the papillary dermis; and LL-37 was concentrated in the stratum corneum and along ducts.

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  • [Cites] Burns. 1999 Aug;25(5):411-3 [10439149.001]
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  • (PMID = 16921412.001).
  • [ISSN] 1554-0766
  • [Journal-full-title] Journal of burns and wounds
  • [ISO-abbreviation] J Burns Wounds
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1501114
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34. Karla PK, Quinn TL, Herndon BL, Thomas P, Pal D, Mitra A: Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. J Ocul Pharmacol Ther; 2009 Apr;25(2):121-32
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  • [Title] Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.
  • PURPOSE: The purpose of this manuscript is to investigate the presence of nucleoside/nucleotide efflux transporter in cornea and to evaluate the role in ocular drug efflux.
  • METHODS: RT-PCR, immunoprecipitation followed by Western blot analysis and immunostaining were employed to establish molecular presence of multidrug resistance associated protein 5 (MRP5) on cornea.
  • Corneal efflux by MRP5 was studied with bis(POM)-PMEA and acyclovir using rabbit and human corneal epithelial cells along with MRP5 over expressing cells (MDCKII-MRP5).
  • Ex vivo studies using excised rabbit cornea and in vivo ocular microdialysis in male New Zealand white rabbits were used to further evaluate the role of MRP5 in conferring ocular drug resistance.
  • RESULTS: RT-PCR confirms the expression of MRP5 in both rabbit and human corneal epithelial cells along with MDCKII-MRP5 cells.
  • Immunoprecipitation followed by Western blot analysis using a rat (M511-54) monoclonal antibody that reacts with human epitope confirms the expression of MRP5 protein in human corneal epithelial cells and MDCKII-MRP5 cells.
  • Immunostaining performed on human cornea indicates the localization of this efflux pump on both epithelium and endothelium.
  • TLC/autoradiography suggested the conversion of bis(POM)-PMEA to PMEA in rabbit and human corneal epithelial cells.
  • Ex vivo study on intact rabbit corneas demonstrated accumulation of PMEA in cornea in the presence of ATP-depleting medium.
  • CONCLUSIONS: Taken together immunolocalization on human cornea, in vitro efflux in human, rabbit corneal and MRP5 over expressing cells, ex vivo and in vivo studies in intact rabbit cornea suggest that MRP5 on cornea can significantly lower the permeability of antiviral and glaucoma drugs.

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  • (PMID = 19323627.001).
  • [ISSN] 1557-7732
  • [Journal-full-title] Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • [ISO-abbreviation] J Ocul Pharmacol Ther
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / 05R01EY009171-14
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCC5 protein, human; 0 / Amides; 0 / Antihypertensive Agents; 0 / Antiviral Agents; 0 / Multidrug Resistance-Associated Proteins; 0 / Propionates; 0 / Prostaglandins F, Synthetic; 0 / Quinolines; 0 / bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine; 4208238832 / Cloprostenol; 5Q9O54P0H7 / verlukast; 6Z5B6HVF6O / latanoprost; JAC85A2161 / Adenine; QXS94885MZ / Bimatoprost; X4HES1O11F / Acyclovir
  • [Other-IDs] NLM/ PMC2963904
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35. Tovar MO, Obando MJ, Gómez E, Caldas ML, Hurtado H: [Histology and morphometry of the in the freshwater Paracheirodon axelrodi (Characiformes: Characidae)]. Rev Biol Trop; 2009 Dec;57(4):1107-18
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  • Cornea of endotelial tissue with two membranes.
  • Cornea thickness was 27.6 microm (SD = 4.3, n = 20); iris thickness was 18.9 microm (SD = 1.9, n = 20); rete mirabilis choroid 22.2 microm (SD = 3.2, n = 20) and sclera: 15.9 microm (SD = 1.2, n = 20).
  • The TRO, areae centrales in the retina, and thin cornea, suggests the need of a well developed visual system resulting from a predatory diet.

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  • (PMID = 20073338.001).
  • [ISSN] 0034-7744
  • [Journal-full-title] Revista de biología tropical
  • [ISO-abbreviation] Rev. Biol. Trop.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Costa Rica
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36. Schrage NF, Kompa S, Ballmann B, Reim M, Langefeld S: Relationship of eye burns with calcifications of the cornea? Graefes Arch Clin Exp Ophthalmol; 2005 Aug;243(8):780-4
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  • [Title] Relationship of eye burns with calcifications of the cornea?
  • INTRODUCTION: The clinical pattern of corneal calcification has been considered to be a part of chronic eye diseases, such as uveitis, severe glaucoma, keratitis and eye burns.
  • Since, in some cases of eye burns, we have found corneal calcifications to be related to the initial calciferous caustic agents and to the use of phosphate-buffer-containing fluids, we have reviewed our files of clinical eye burns for the incidence and appearance of corneal calcification.
  • RESULTS: Calciferous burning agents and corneal calcification are correlated (P<0.01).
  • Initial single rinsing with phosphate does not produce corneal calcification (P=0.134).
  • There is evidence that corneal calcifications are correlated with chronically administered phosphate-buffered eye drops (P<0.005).
  • We present case reports of three different types of eye burns and later therapy resulting in corneal calcification.
  • Corneal calcifications are presumably related to longer-lasting phosphate application.
  • In cases of chronic corneal disturbance, we recommend the elimination of phosphate-buffered medications to prevent corneal calcification.
  • [MeSH-major] Burns, Chemical / drug therapy. Calcinosis / chemically induced. Corneal Diseases / chemically induced. Eye Burns / chemically induced
  • [MeSH-minor] Adolescent. Adult. Aged. Calcium Compounds / adverse effects. Child. Cornea / drug effects. Cornea / metabolism. Female. Homeostasis. Humans. Male. Middle Aged. Ophthalmic Solutions. Oxides / adverse effects. Retrospective Studies. Water-Electrolyte Imbalance / metabolism

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  • (PMID = 15756579.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calcium Compounds; 0 / Ophthalmic Solutions; 0 / Oxides; C7X2M0VVNH / lime
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37. Aptel F, Olivier N, Deniset-Besseau A, Legeais JM, Plamann K, Schanne-Klein MC, Beaurepaire E: Multimodal nonlinear imaging of the human cornea. Invest Ophthalmol Vis Sci; 2010 May;51(5):2459-65
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  • [Title] Multimodal nonlinear imaging of the human cornea.
  • PURPOSE: To evaluate the potential of third-harmonic generation (THG) microscopy combined with second-harmonic generation (SHG) and two-photon excited fluorescence (2PEF) microscopies for visualizing the microstructure of the human cornea and trabecular meshwork based on their intrinsic nonlinear properties.
  • METHODS: Fresh human corneal buttons and corneoscleral discs from an eye bank were observed under a multiphoton microscope incorporating a titanium-sapphire laser and an optical parametric oscillator for the excitation, and equipped with detection channels in the forward and backward directions.
  • RESULTS: Original contrast mechanisms of THG signals in cornea with physiological relevance were elucidated.
  • This imaging method should prove particularly useful for assessing glaucoma and corneal physiopathologies.
  • [MeSH-major] Cornea / cytology. Microscopy, Fluorescence, Multiphoton / methods
  • [MeSH-minor] Collagen / analysis. Corneal Edema / pathology. Corneal Stroma / cytology. Endothelium, Corneal / cytology. Epithelium, Corneal / cytology. Eye Banks. Fluorescence Polarization. Humans. Sclera / cytology. Tissue Donors. Trabecular Meshwork / cytology

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  • (PMID = 20071677.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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38. Feldman BH, Kim T: Enhanced effect of double-stacked intrastromal corneal ring segments in keratoconus. J Cataract Refract Surg; 2010 Feb;36(2):332-5
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  • [Title] Enhanced effect of double-stacked intrastromal corneal ring segments in keratoconus.
  • We present a patient with poor visual acuity and contact lens intolerance due to advanced keratoconus who had femtosecond-assisted placement of two 0.35 mm intrastromal corneal ring segments (ICRS) in the right eye.
  • This resulted in a dramatic central shift of the cone and flattening of the inferior paracentral cornea with significant improvement in vision.
  • To our knowledge, this is the first report of double-stacked ICRS in a human cornea and raises the possibility that significantly thicker segments may provide enhanced anatomic and visual effects in some keratoectatic patients.
  • [MeSH-major] Corneal Stroma / surgery. Keratoconus / surgery. Prostheses and Implants. Prosthesis Implantation
  • [MeSH-minor] Corneal Topography. Humans. Male. Middle Aged. Visual Acuity / physiology

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  • [Copyright] Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20152617.001).
  • [ISSN] 1873-4502
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. dal Belo SE, Gaspar LR, Maia Campos PM, Marty JP: Skin penetration of epigallocatechin-3-gallate and quercetin from green tea and Ginkgo biloba extracts vehiculated in cosmetic formulations. Skin Pharmacol Physiol; 2009;22(6):299-304
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  • The stratum corneum was removed by tape stripping and immersed in methanol and the epidermis was mechanically separated from the dermis and triturated in methanol to extract EGCG and quercetin.
  • The majority of EGCG was quantified in the stratum corneum (0.87 microg/cm(2)), which was statistically higher than the EGCG concentrations found in viable epidermis (0.54 microg/cm(2)) and in the dermis (0.38 microg/cm(2)).
  • The majority of quercetin was quantified in the viable epidermis (0.23 microg/cm(2)), which was statistically higher than the EGCG concentration found in the stratum corneum layer (0.17 microg/cm(2)).

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  • (PMID = 19786823.001).
  • [ISSN] 1660-5535
  • [Journal-full-title] Skin pharmacology and physiology
  • [ISO-abbreviation] Skin Pharmacol Physiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Cosmetics; 0 / Plant Extracts; 8R1V1STN48 / Catechin; 9IKM0I5T1E / Quercetin; BQM438CTEL / epigallocatechin gallate
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40. Isnard N, Bourles-Dagonet F, Robert L, Renard G: Studies on corneal wound healing. Effect of fucose on iodine vapor-burnt rabbit corneas. Ophthalmologica; 2005 Nov-Dec;219(6):324-33
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  • [Title] Studies on corneal wound healing. Effect of fucose on iodine vapor-burnt rabbit corneas.
  • Corneal wound healing often leads to the development of scar tissue with loss of transparency.
  • Reconstitution of transparent corneal stroma depends on the regulation of the biosynthetic activities of postlesional keratocytes and also to a large extent on the limitation of matrix degradation, attributed essentially to the upregulation of matrix metalloproteases and especially MMP-9.
  • Using a standardized method for the production of reproducible corneal lesions by burning with iodine vapors, we could show that the local application of 0.5 mg/ml L-fucose reduced significantly MMP-9 upregulation and accelerated the recovery of the epithelial layer of the cornea.
  • In order to study the effect of fucose on normal corneas, it was added to rabbit as well as human cornea explant cultures, and the production and release of MMP-9 was determined by zymography.
  • Fucose at a concentration of 0.5 mg/ml produced a 70% decrease of MMP-9 activity released in the medium by corneal explant cultures.
  • These results justify the use of fucose for the local treatment of corneal wounds.
  • [MeSH-major] Burns, Chemical / drug therapy. Epithelium, Corneal / drug effects. Eye Burns / chemically induced. Fucose / therapeutic use. Matrix Metalloproteinase 9 / metabolism. Wound Healing / drug effects

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16286790.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 3713-31-3 / Fucose; 9679TC07X4 / Iodine; EC 3.4.24.35 / Matrix Metalloproteinase 9
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41. Jungersted JM, Høgh JK, Hellgren LI, Jemec GB, Agner T: Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides. Arch Dermatol Res; 2010 Nov;302(9):653-6
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  • [Title] Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides.
  • To investigate the effect of systemic alitretinoin on skin barrier function and response to irritants, a secondary objective was to determine if changes occur in the lipid profile of stratum corneum after treatment with systemic alitretinoin.
  • No significant changes in stratum corneum lipids were found after 2 months of treatment.
  • In conclusion, systemic alitretinoin does not influence skin susceptibility to irritants or the ceramide profile of stratum corneum.

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  • (PMID = 20535487.001).
  • [ISSN] 1432-069X
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ceramides; 0 / Irritants; 0 / Retinoids; 368GB5141J / Sodium Dodecyl Sulfate; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin
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42. Stiles J, Pogranichniy R: Detection of virulent feline herpesvirus-1 in the corneas of clinically normal cats. J Feline Med Surg; 2008 Apr;10(2):154-9
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  • To evaluate the clinically normal feline cornea for the presence of virulent feline herpesvirus-1 (FHV-1), corneas from 31 cats (25 with normal eyes and six with active disease or corneal scarring) euthanased at a shelter were collected.
  • One cornea was positive for feline calicivirus (FCV) in addition to FHV-1, but only in media that included dexamethasone.
  • VI and rt-PCR were negative for FHV-1 and FCV in cats with active disease or corneal scarring.
  • [MeSH-major] Cat Diseases / virology. Cornea / virology. Corneal Diseases / veterinary. Herpesviridae / isolation & purification. Herpesviridae Infections / veterinary

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  • (PMID = 18155950.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7S5I7G3JQL / Dexamethasone
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43. Kashiwagi H: [Ocular disorders of anticancer drugs--ocular side effects]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1639-44
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  • We report have eye disorders caused by anticancer drugs on the ocular surface (eyelids, conjunctiva, cornea), retina, optic nerve, and sites of the lacrymal ducts.
  • For disorders of the anterior ocular segment, we use gefitinib (Iressa®) and erlotinib (Tarceba®), cetuximab (Arbitax®) for trichomegaly while for lacrymal duct disorders and retinas with corneal problems revolt biochemistry, S-1 (TS-1®), erlotinib, docetaxel, paclitaxel and tamoxifen, paclitaxel, tamoxifen, optic neuropathy with 5-fluorouracil (5-FU), S-1 and docetaxel have been reported.
  • Eye disorders can be relieved by discontinuation of the anticancer drug, but one may cause irreversible change, and early diagnosis and treatment are required.

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  • (PMID = 20841924.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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44. Helvik JV, Rødahl E, Drivenes Ø, Haarr L: Identification and characterization of two zebrafish nectin-1 genes that are differentially expressed in the developing eye and brain. Dev Dyn; 2009 Jan;238(1):43-55
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  • Only nectin-1a was detected in the cornea, the lens, and in the region of photoreceptor cell differentiation in the retina.

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
  • (PMID = 19097185.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Protein Isoforms; 0 / Zebrafish Proteins; 0 / nectins
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45. Oster SF, Ebrahimi KB, Eberhart CG, Schein OD, Stark WJ, Jun AS: A clinicopathologic series of primary graft failure after Descemet's stripping and automated endothelial keratoplasty. Ophthalmology; 2009 Apr;116(4):609-14
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  • MAIN OUTCOME MEASURES: Examination of specimens for corneal endothelial cell viability and host-donor interface characteristics.
  • RESULTS: Clinical history revealed that 88% (14/16) of studied DSAEK grafts detached before failure, and pathologic examination found that 75% (12/16) of failed grafts had atrophic corneal endothelium.
  • CONCLUSIONS: Marked loss of the corneal endothelium is the prominent feature of primary DSAEK graft failure.
  • Examples of surgical features, such as incomplete Descemet's stripping and residual full-thickness cornea with a DSAEK graft, are shown.
  • [MeSH-major] Corneal Transplantation / pathology. Descemet Membrane / pathology. Endothelium, Corneal / pathology. Endothelium, Corneal / transplantation. Graft Rejection / pathology

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  • [CommentIn] Ophthalmology. 2009 Apr;116(4):601-2 [19344818.001]
  • [CommentIn] Ophthalmology. 2009 Dec;116(12):2481-2; author reply 2482 [19948285.001]
  • (PMID = 18962919.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Kim EC, Kim DJ, Lee SS, Kim MS: Ultrastructural changes of cornea after ethanol ingestion in Otsuka Long-Evans Tokushima fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats. Graefes Arch Clin Exp Ophthalmol; 2010 Oct;248(10):1457-66
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  • [Title] Ultrastructural changes of cornea after ethanol ingestion in Otsuka Long-Evans Tokushima fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats.
  • Central corneal thickness (CCT) was measured with an ultrasound pachymeter after 11 weeks.
  • After corneal buttons were excised, transmission electron microscopy (TEM) examination was performed.
  • CONCLUSIONS: Corneal ultrastructural damage can develop in the pre-diabetic stage and when alcohol is ingested chronically in rats.
  • [MeSH-major] Cornea / drug effects. Cornea / ultrastructure. Diabetes Mellitus, Type 2 / pathology. Disease Models, Animal. Ethanol / toxicity

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  • (PMID = 20582705.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Reactive Oxygen Species; 3K9958V90M / Ethanol
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47. Rogers MS, Birsner AE, D'Amato RJ: The mouse cornea micropocket angiogenesis assay. Nat Protoc; 2007;2(10):2545-50
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  • [Title] The mouse cornea micropocket angiogenesis assay.
  • The mouse corneal micropocket angiogenesis assay uses the avascular cornea as a canvas to study angiogenesis in vivo.
  • A micropocket is surgically created in the mouse cornea and a pellet implanted.
  • Five days later, the area of the cornea overgrown by the angiogenic response is measured using a slit lamp.
  • [MeSH-major] Cornea / blood supply. Corneal Neovascularization

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  • (PMID = 17947997.001).
  • [ISSN] 1750-2799
  • [Journal-full-title] Nature protocols
  • [ISO-abbreviation] Nat Protoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 62031-54-3 / Fibroblast Growth Factors
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48. Zhang J, Carraway CA, Carraway KL: Muc4 expression during blood vessel formation in damaged rat cornea. Curr Eye Res; 2006 Dec;31(12):1011-4
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  • [Title] Muc4 expression during blood vessel formation in damaged rat cornea.
  • PURPOSE: To determine the timing of Muc4 expression during the association of endothelial cells to form blood vessels in the rat corneal stroma after corneal wounding.
  • METHODS: Corneal damage was inflicted using brief cauterization with silver nitrite.
  • RESULTS: Blood vessels and von Willebrand Factor-stained cells were very sparse in corneal stroma from unwounded corneas.
  • [MeSH-major] Burns, Chemical / metabolism. Corneal Stroma / blood supply. Endothelium, Vascular / metabolism. Eye Burns / chemically induced. Mucins / metabolism. Neovascularization, Physiologic / physiology

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  • (PMID = 17169838.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY12343
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muc4 protein, rat; 0 / Mucin-4; 0 / Mucins; 0 / Sialoglycoproteins; 0 / von Willebrand Factor; 95IT3W8JZE / Silver Nitrate
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49. Niederer RL, Perumal D, Sherwin T, McGhee CN: Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol; 2007 Sep;91(9):1165-9
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  • [Title] Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study.
  • AIMS: To quantify and establish baseline normative data for age-related differences in cellular and innervation density in the normal, healthy, human cornea using laser scanning in vivo confocal microscopy.
  • METHODS: Cross-sectional study of 85 normal subjects assessed via corneal topography and laser scanning in vivo confocal microscopy.
  • No association was observed between age and basal epithelial cell density, or between age and central corneal thickness, corneal astigmatism or horizontal corneal diameter (p>0.05).
  • No association was observed between subject gender and corneal cell or innervation density.
  • Interestingly, corneal sub-basal nerve fibre density also significantly decreases with increasing age.
  • In vivo laser scanning confocal microscopy provides a safe, non-invasive method for the establishment of normative data and assessment of alterations in human corneal microstructure following surgery or disease processes.
  • [MeSH-major] Aging / pathology. Cornea / cytology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Count. Corneal Topography / methods. Endothelium, Corneal / cytology. Epithelium, Corneal / cytology. Female. Humans. Image Processing, Computer-Assisted / methods. Laser Scanning Cytometry / methods. Male. Microscopy, Confocal. Middle Aged. Nerve Fibers / ultrastructure

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  • (PMID = 17389741.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1954900
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50. Smetankin IG: [Capacities of infrared teleradiopyrometry in determining the temperature of a corneal wound during cataract phacoemulsification]. Vestn Oftalmol; 2009 Sep-Oct;125(5):12-5
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  • [Title] [Capacities of infrared teleradiopyrometry in determining the temperature of a corneal wound during cataract phacoemulsification].
  • Infrared teleradiopyrometry was used to determine the temperature of a corneal wound by ultrasonic extracapsular phacoemulsification (EP) on 55 eyes of patients with cataract.
  • The investigations showed that infrared teleradiopyrometry was a rather accurate and valid technique for determining the temperature of a corneal cut during EP; to lower thermal exposure of the cornea, it is more efficient to carry out micropulse bimanual phacoemulsification with the ultrasonic power of not more than 40%; if a ultrasonic power more than 50-60 is needed, it is more rational to use a flash mode.
  • [MeSH-major] Body Temperature. Cornea / physiology. Infrared Rays. Monitoring, Intraoperative / methods. Phacoemulsification / methods. Telemetry / methods. Thermography / methods

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  • (PMID = 19916326.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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51. Rothmayer M, Dultz W, Frins E, Zhan Q, Tierney D, Schmitzer H: Nonlinearity in the rotational dynamics of Haidinger's brushes. Appl Opt; 2007 Oct 10;46(29):7244-51
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  • We find that the birefringence of the cornea influences the rotational motion and the contrast of Haidinger's brushes and may offer an explanation for individual differences.
  • We have devised an experimental setup to simulate various phase shifts of the cornea and found a switching effect in the rotational dynamics of Haidinger's brushes.
  • [MeSH-major] Birefringence. Macular Degeneration / diagnosis. Optics and Photonics. Vision, Ocular

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  • (PMID = 17932536.001).
  • [ISSN] 0003-6935
  • [Journal-full-title] Applied optics
  • [ISO-abbreviation] Appl Opt
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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52. Sakimoto T, Rosenblatt MI, Azar DT: Laser eye surgery for refractive errors. Lancet; 2006 Apr 29;367(9520):1432-47
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  • Several laser and non-laser refractive surgical procedures have been used to modify the shape of the cornea and correct myopia, hyperopia, astigmatism, and presbyopia.
  • Introduction of the excimer laser to reshape the cornea has resulted in remarkable developments in the correction of these refractive errors.
  • [MeSH-major] Cornea. Laser Therapy / methods. Photorefractive Keratectomy / methods. Refractive Surgical Procedures

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  • (PMID = 16650653.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY10101
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 120
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53. Fenk LM, Heidlmayr K, Lindner P, Schmid A: Pupil size in spider eyes is linked to post-ecdysal lens growth. PLoS One; 2010;5(12):e15838
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  • MicroCT images suggest that the decrease of the pigment ring is linked to the growth of the corneal lens after ecdysis.
  • The pigment rings might improve vision in the immature eye by shielding light rays that would otherwise enter the eye via peripheral regions of the cornea, beside the growing crystalline lens.
  • [MeSH-minor] Animals. Cornea / pathology. Lens, Crystalline / growth & development. Lens, Crystalline / physiology. Light. Pigmentation. Spiders. Temperature. Time Factors. X-Ray Microtomography / methods

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  • (PMID = 21209876.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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54. Atchison DA, Charman WN: Thomas Young's contribution to visual optics: the Bakerian Lecture "on the mechanism of the eye". J Vis; 2010;10(12):16
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  • He considered the different possible origins of accommodation and confirmed that it was due to change in shape of the lens rather than to change in shape of the cornea or an increase in axial length.

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  • (PMID = 21047748.001).
  • [ISSN] 1534-7362
  • [Journal-full-title] Journal of vision
  • [ISO-abbreviation] J Vis
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Young T
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55. Tanaka G, Smith RJ, Siveter DJ, Parker AR: Three-dimensionally preserved decapod larval compound eyes from the Cretaceous Santana Formation of Brazil. Zoolog Sci; 2009 Dec;26(12):846-50
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  • The fossil eyes are comparable to phyllosoma larval eyes because of the following characters: the hemispherical visual surface on a stalked eye; the relatively small-size of the visual surface of the eye; rounded facets are arranged in square arrays in the anterior region; the fact that the neighboring ommatidia are bounded by ridges and/ or grooves; and the more convex inner surface of the cornea lens.

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  • (PMID = 19968472.001).
  • [ISSN] 0289-0003
  • [Journal-full-title] Zoological science
  • [ISO-abbreviation] Zool. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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56. Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP: Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp Eye Res; 2008 Oct;87(4):376-84
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  • Three of the six monoclonal antibodies recognize the N-terminus of myocilin (amino acids 33-214), two antibodies recognize the middle third of the protein (amino acids 215-368), and one antibody recognizes the C-terminus (amino acids 369-504).
  • Myocilin was also detected by immunohistochemistry in trabecular meshwork, ciliary body, iris, cornea, sclera, choroid, and retinal pigment epithelial cells.

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  • (PMID = 18674535.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY015736-04; United States / NEI NIH HHS / EY / EY007065-22; United States / NEI NIH HHS / EY / F32 EY007065; United States / NEI NIH HHS / EY / R01 EY014411; United States / NEI NIH HHS / EY / EY15736; United States / NEI NIH HHS / EY / R01 EY015736; United States / NEI NIH HHS / EY / R01 EY015736-04; United States / NEI NIH HHS / EY / EY14411; United States / NEI NIH HHS / EY / R01 EY007065-22; United States / NEI NIH HHS / EY / EY07065; United States / NEI NIH HHS / EY / R01 EY007065
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Culture Media, Conditioned; 0 / Cytoskeletal Proteins; 0 / Eye Proteins; 0 / Glycoproteins; 0 / Recombinant Proteins; 0 / trabecular meshwork-induced glucocorticoid response protein
  • [Other-IDs] NLM/ NIHMS72534; NLM/ PMC2866087
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57. Pisella PJ: [The cellular players in allergy]. J Fr Ophtalmol; 2007 Mar;30(3):283-7
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  • [Transliterated title] Les acteurs cellulaires de l'allergie.
  • The cornea could also be involved in allergic diseases, mostly in severe ones such as vernal or atopic keratoconjunctivitis, but most often, its pathology is due to direct cytotoxic effect of chemical mediators, such as eosinophil proteins, rarely results from mechanical or immunological pathways.
  • [MeSH-minor] Antigen-Presenting Cells / immunology. Conjunctiva / immunology. Conjunctiva / pathology. Cornea / immunology. Cornea / pathology. Eosinophils / immunology. Humans. Immunity, Cellular. Langerhans Cells / immunology. Lymphocyte Subsets / immunology. Macrophages / immunology. Mast Cells / immunology. Rhinitis, Allergic, Perennial / complications. Rhinitis, Allergic, Perennial / epidemiology. Rhinitis, Allergic, Seasonal / complications. Rhinitis, Allergic, Seasonal / epidemiology. Tears / physiology

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  • (PMID = 17417155.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 13
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58. Hong S, Kim CY, Seong GJ, Hong YJ: Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure. Am J Ophthalmol; 2007 Feb;143(2):362-3
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  • [Title] Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure.
  • PURPOSE: To determine the association of central corneal thickness (CCT) and visual field progression in patients with chronic primary angle-closure glaucoma (CPACG) with low intraocular pressure (IOP).
  • CONCLUSIONS: Patients with CPACG with a thinner cornea are at greater risk for visual field progression even if they maintain a low IOP after treatment.
  • [MeSH-major] Cornea / pathology. Glaucoma, Angle-Closure / complications. Intraocular Pressure. Vision Disorders / etiology. Visual Fields

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  • (PMID = 17258538.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Pamuk S: A mathematical model for capillary formation and development in tumor angiogenesis: a review. Chemotherapy; 2006;52(1):35-7
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  • [Title] A mathematical model for capillary formation and development in tumor angiogenesis: a review.
  • Following tumor angiogenic growth factors, EC in neighboring normal capillaries are activated to secrete proteases.
  • CONCLUSIONS: We obtained a very good computational agreement with the rabbit cornea experiments of Folkman [Sci Am 1976;234:58-64].
  • [MeSH-minor] Angiostatins. Animals. Cornea. Endothelial Cells / metabolism. Endothelial Cells / pathology. Fibronectins / biosynthesis. Peptide Hydrolases / metabolism. Rabbits

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  • (PMID = 16340197.001).
  • [ISSN] 0009-3157
  • [Journal-full-title] Chemotherapy
  • [ISO-abbreviation] Chemotherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Fibronectins; 86090-08-6 / Angiostatins; EC 3.4.- / Peptide Hydrolases
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60. Duchateau N, Hugol D, D'Hermies F, Meyer A, Labbé A, Dupas B, Iordanidou V, Renard G, Baudouin C: [Contribution of in vivo confocal microscopy to limbal tumor evaluation]. J Fr Ophtalmol; 2005 Oct;28(8):810-6
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  • [Title] [Contribution of in vivo confocal microscopy to limbal tumor evaluation].
  • [Transliterated title] Apport de la microscopie confocale in vivo dans l'exploration de tumeurs limbiques.
  • METHODS: We evaluated three tumors in three patients with the Heidelberg Retina Tomograph II, Rostock Cornea Module.
  • CONCLUSION: Our preliminary study showed that this type of limbal tumor could be explored using in vivo confocal microscopy.
  • [MeSH-major] Corneal Diseases / pathology. Eye Neoplasms / pathology. Limbus Corneae

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  • (PMID = 16249759.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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61. Kwok LS, Pierscionek BK, Bullimore M, Swarbrick HA, Mountford J, Sutton G: Orthokeratology for myopic children: wolf in sheep's clothing? Clin Exp Ophthalmol; 2005 Aug;33(4):343-7
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  • Orthokeratology attempts to reduce myopia by remoulding the corneal shape with contact lenses.
  • Some state that there is a lack of data on relative risks of corneal infection and that there is a need for large-scale randomized controlled studies; however, opinion is expressed by others that orthokeratology is a clinically safe procedure using modern lenses.
  • It is noted that the physiological and biophysical bases of orthokeratology are virtually unknown, and further research on the human cornea is indicated to scientifically establish the safety of orthokeratology.
  • [MeSH-minor] Child. Child, Preschool. Cornea / physiopathology. Humans. Infant. Prescriptions / statistics & numerical data. Prosthesis Fitting

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  • [CommentIn] Clin Exp Ophthalmol. 2005 Aug;33(4):341-2 [16033341.001]
  • (PMID = 16033342.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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62. Diago T, Harto M, Serra I, Pardo D, Montero J, Díaz-Llopis M: [Aniridia, congenital glaucoma and white corneas in a newborn baby]. Arch Soc Esp Oftalmol; 2009 Nov;84(11):573-6
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  • CASE REPORT: We present the case of a newborn baby in whom we observed aniridia, congenital glaucoma and edematous corneas, without clearance of the cornea after glaucoma surgery, and in whom a keratoplasty was considered.
  • [MeSH-major] Abnormalities, Multiple. Aniridia / complications. Cornea / abnormalities. Glaucoma / complications. Glaucoma / congenital


63. Bantseev V, McCanna DJ, Driot JY, Sivak JG: The effects of toxicological agents on the optics and mitochondria of the lens and the mitochondria of the corneal epithelium. Semin Cell Dev Biol; 2008 Apr;19(2):150-9
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  • [Title] The effects of toxicological agents on the optics and mitochondria of the lens and the mitochondria of the corneal epithelium.
  • This research was correlated with an effort to use the optical properties of the intact lens in culture as a proxy for the cornea in measuring ocular toxicity.
  • In turn, this work led to the confocal study of the in vitro and then the in vivo cornea and their possible use in using confocal microscopy to evaluate the effect of various treatments on the integrity of the surface of the eye.
  • [MeSH-major] Alcohols / toxicity. Epithelium, Corneal / drug effects. Lens, Crystalline / drug effects. Mitochondria / drug effects. Optics and Photonics. Surface-Active Agents / toxicity
  • [MeSH-minor] Animals. Cornea / anatomy & histology. Cornea / ultrastructure. Humans. Organ Culture Techniques. Toxicity Tests / methods. Toxicology / methods

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  • (PMID = 17936038.001).
  • [ISSN] 1084-9521
  • [Journal-full-title] Seminars in cell & developmental biology
  • [ISO-abbreviation] Semin. Cell Dev. Biol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alcohols; 0 / Surface-Active Agents
  • [Number-of-references] 74
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64. Komatsu N, Saijoh K, Sidiropoulos M, Tsai B, Levesque MA, Elliott MB, Takehara K, Diamandis EP: Quantification of human tissue kallikreins in the stratum corneum: dependence on age and gender. J Invest Dermatol; 2005 Dec;125(6):1182-9
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  • [Title] Quantification of human tissue kallikreins in the stratum corneum: dependence on age and gender.
  • hK5, hK6, hK7, hK8, and hK13 have been identified in the stratum corneum (SC), stratum granulosum, and skin appendages.

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  • (PMID = 16354188.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.35 / Tissue Kallikreins; EC 3.4.21.4 / Trypsin
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65. Descargues P, Deraison C, Prost C, Fraitag S, Mazereeuw-Hautier J, D'Alessio M, Ishida-Yamamoto A, Bodemer C, Zambruno G, Hovnanian A: Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome. J Invest Dermatol; 2006 Jul;126(7):1622-32
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  • [Title] Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome.
  • SPINK5 (serine protease inhibitor Kazal-type 5), encoding the protease inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor), is the defective gene in Netherton syndrome (NS), a severe inherited keratinizing disorder.
  • Stratum corneum tryptic enzyme (SCTE)-like and stratum corneum chymotryptic enzyme (SCCE)-like activities were increased, suggesting that these proteases participate in the premature degradation of corneodesmosomal cadherins.

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  • (PMID = 16628198.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / DSC1 protein, human; 0 / Desmocollins; 0 / Desmoglein 1; 0 / Membrane Glycoproteins; 0 / Proteinase Inhibitory Proteins, Secretory; 0 / Receptor, PAR-2; 0 / SPINK5 protein, human; EC 3.4.21.- / KLK5 protein, human; EC 3.4.21.- / KLK7 protein, human; EC 3.4.21.- / Kallikreins
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66. Ruffien-Ciszak A, Gros P, Comtat M, Schmitt AM, Questel E, Casas C, Redoules D: Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry. J Pharm Biomed Anal; 2006 Jan 23;40(1):162-7
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  • [Title] Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry.
  • This method ensured a direct, rapid (less than 1 min), reliable (accuracy 12%) and non-invasive measurement of the global antioxidant capacity of the stratum corneum with a high spatiotemporal resolution.

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  • (PMID = 16137853.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Free Radical Scavengers; 0 / Reactive Oxygen Species; PQ6CK8PD0R / Ascorbic Acid
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67. Tsuzuki K, Yamashita K, Izumisawa Y, Kotani T: Microstructure and glycosaminoglycan ratio of canine cornea after reconstructive transplantation with glycerin-preserved porcine amniotic membranes. Vet Ophthalmol; 2008 Jul-Aug;11(4):222-7
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  • [Title] Microstructure and glycosaminoglycan ratio of canine cornea after reconstructive transplantation with glycerin-preserved porcine amniotic membranes.
  • OBJECTIVE: Although amniotic membranes of canine, feline, and equine species have some advantages as corneal transplantation material in many canine ocular diseases, their softness, thinness, and low availability can pose problems.
  • This paper describes the use of glycerin-preserved porcine amniotic membranes in corneal transplantation in eight normal dogs.
  • METHOD: A 0.4-mm deep recipient bed in the axial cornea of the OS of all dogs was created using an 8-mm Barron radial vacuum trephine.
  • The recipient bed was then filled with amnion, and the entire cornea was covered with another piece of the glycerin-preserved membrane.
  • The ocular signs evaluated were corneal opacity and corneal vascularization.
  • The dogs were euthanized on days 5, 10, 20, or 40 after surgery, and samples were collected to evaluate corneal thickness, parenchymal cell number, mean collagen fibril diameter, collagen fibril content and the glycosaminoglycan (GAG) ratio.
  • RESULTS: Corneal opacity was observed immediately after surgery.
  • Restoration of corneal transparency, regression of corneal vascularization, and visualization of the pupil and iris were noted on day 40.
  • CONCLUSIONS: The clinical observations were supported histologically by regained corneal thickness, parenchymal cell number, mean collagen fibril diameter, collagen fibril content, and GAG ratio, suggesting that this technique may be a novel method for the treatment of ocular surface disorders.
  • [MeSH-major] Amnion / transplantation. Corneal Diseases / veterinary. Corneal Transplantation / veterinary. Dog Diseases / surgery
  • [MeSH-minor] Animals. Cornea / pathology. Cornea / ultrastructure. Dogs. Female. Glycosaminoglycans / analysis. Male. Microscopy, Electron, Transmission / veterinary. Random Allocation. Swine. Transplantation, Heterologous / veterinary. Treatment Outcome

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  • (PMID = 18638347.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glycosaminoglycans
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68. Every SG, Leader JP, Molteno AC, Bevin TH, Sanderson G: Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns. Invest Ophthalmol Vis Sci; 2005 Oct;46(10):3616-22
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  • [Title] Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns.
  • PURPOSE: To perform ultraviolet (UV) macrophotography of the normal in vivo human cornea, establishing biometric data of the major component of UV absorption for comparison with the Hudson-Stähli (HS) line, the distribution of iron demonstrated by Perl stain, and cases of typical amiodarone keratopathy.
  • Image-analysis software was used to grade the major component of UV absorption for slope and the coordinates of its points of intersection with the vertical corneal meridian and inflection.
  • RESULTS: In group 1 the major component had a mean slope of 5.8 degrees, sloping down from nasal to temporal cornea.
  • The mean coordinates of points of intersection with the vertical corneal meridian and inflection were (0, 0.30) and (0.02, 0.31), respectively.
  • No significant differences between groups 1 and 2 were found for slope (P = 0.155), intersection with the vertical corneal meridian (P = 0.517), and point of inflection (P = 0.344).
  • The major component of UV absorption was consistent with published characteristics of the HS line, and coincidence of UV absorption and Perl-stained iron was demonstrated in one corneal button.
  • CONCLUSIONS: UV photography demonstrates subclinical corneal iron, confirming its deposition in an integrated HS line/vortex pattern.
  • [MeSH-major] Cornea / anatomy & histology. Cornea / physiology. Photography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amiodarone / adverse effects. Corneal Diseases / chemically induced. Corneal Diseases / metabolism. Corneal Diseases / pathology. Female. Ferritins / metabolism. Humans. Iron / metabolism. Male. Middle Aged. Ultraviolet Rays

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  • (PMID = 16186341.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-73-2 / Ferritins; E1UOL152H7 / Iron; N3RQ532IUT / Amiodarone
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69. Piérard GE, Piérard-Franchimont C, Quatresooz P: Updating corneofungimetry: a bioassay exploring dermatomycoses and antifungal susceptibility. Mycopathologia; 2010 Jan;169(1):27-35
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  • The corneofungimetry bioassay was designed to test comparatively a series of antifungals on pathogenic fungi growing on sheets of human stratum corneum.

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  • (PMID = 19644764.001).
  • [ISSN] 1573-0832
  • [Journal-full-title] Mycopathologia
  • [ISO-abbreviation] Mycopathologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antifungal Agents
  • [Number-of-references] 69
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70. Uzal FA, Houston RS, Riley SP, Poppenga R, Odani J, Boyce W: Notoedric mange in two free-ranging mountain lions (Puma concolor). J Wildl Dis; 2007 Apr;43(2):274-8
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  • The diagnosis of notoedric mange was confirmed by histology and direct examination of mites obtained from skin scrapings of the two animals.
  • Histologically, the affected skin showed acanthotic epidermis with parakeratosis and parasitic tunnels in the stratum corneum.

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  • (PMID = 17495313.001).
  • [ISSN] 0090-3558
  • [Journal-full-title] Journal of wildlife diseases
  • [ISO-abbreviation] J. Wildl. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rodenticides
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71. Piérard-Franchimont C, Piérard GE: [Spotlight on sensory irritation and its treatment]. Rev Med Liege; 2005 Oct;60(10):796-8
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  • The responsible ingredients are often agents affecting functions of stratum corneum without being obvious chemical irritants.

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  • (PMID = 16358667.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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72. Ghosn MG, Tuchin VV, Larin KV: Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography. Invest Ophthalmol Vis Sci; 2007 Jun;48(6):2726-33
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  • [Title] Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography.
  • In this study the authors investigated the capability of optical coherence tomography (OCT) for noninvasive monitoring and quantification of diffusion of different analytes in sclera and cornea of rabbit eyes.
  • Diffusion of different analytes was monitored and quantified in rabbit cornea and sclera of whole eyeballs.
  • For instance, mannitol was found to have a permeability coefficient of (8.99 +/- 1.43) x 10(-6) cm/s in cornea and (6.18 +/- 1.08) x 10(-6) cm/s in sclera.
  • [MeSH-major] Ciprofloxacin / pharmacokinetics. Cornea / metabolism. Dexamethasone / pharmacokinetics. Mannitol / pharmacokinetics. Metronidazole / pharmacokinetics. Sclera / metabolism. Tomography, Optical Coherence / methods

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  • (PMID = 17525205.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 140QMO216E / Metronidazole; 3OWL53L36A / Mannitol; 5E8K9I0O4U / Ciprofloxacin; 7S5I7G3JQL / Dexamethasone
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73. Wozniak K, Sommer F: [Surgical management of entropion]. Ophthalmologe; 2010 Oct;107(10):905-10
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  • As a result of persistent entropion and trichiasis severe complications of the conjunctiva and the cornea can occur, which can lead to loss of visual acuity.

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  • (PMID = 20706724.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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74. Huang FC, Chen WJ, Shih MH: Paederus-induced keratitis. Cornea; 2010 Aug;29(8):941-3
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  • The outcomes and healing course of the corneal lesions were recorded.
  • All patients had diffuse punctate epithelial erosions or large epithelial defects on the unilateral cornea.
  • Prolonged corneal epithelialization was noted after lubrication with artificial tears and wearing a contact lens.
  • Two patients healed with a faint corneal scar.
  • CONCLUSIONS: Paederus-induced keratitis could result in extensive involvement of the corneal surface.
  • [MeSH-major] Beetles. Corneal Injuries. Insect Bites and Stings / complications. Keratitis / etiology

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  • (PMID = 20657212.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Tajika T, Takahashi H, Sakai Y, Fujii H, Isowaki A, Sakaki H: Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion. Xenobiotica; 2010 Aug;40(8):569-77
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  • At 0.5 and 2 h after instillation, DFBA was not detected in the cornea, aqueous humor, or iris/ciliary body.
  • The unknown metabolite was identified as de-17-side chain-glucocorticoid metabolite (DF21C), which is a novel glucocorticoid metabolite formed by the scission of the 17-side chain via an unknown metabolic reaction pathway.
  • [MeSH-major] Aqueous Humor / metabolism. Ciliary Body / metabolism. Cornea / metabolism. Fluprednisolone / analogs & derivatives. Glucocorticoids / pharmacokinetics

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  • (PMID = 20509750.001).
  • [ISSN] 1366-5928
  • [Journal-full-title] Xenobiotica; the fate of foreign compounds in biological systems
  • [ISO-abbreviation] Xenobiotica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dosage Forms; 0 / Glucocorticoids; 0 / Ophthalmic Solutions; 9H05937G3X / Fluprednisolone; S8A06QG2QE / difluprednate
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76. Shi XH, Wu QM, Li XR, Liu WA, Tan T, Yang ZH, Li L: [Clinical observation on Tongdu Tiaojin needling method for treatment of blepharoptosis]. Zhongguo Zhen Jiu; 2008 Dec;28(12):885-7
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  • RESULTS: The cured rate of 41.4% and the effective rate of 82.8% in the observation group were better than 24.1% and 48.2% in the control group (P<0.05); after treatment, the palpebral fissure widened and the level of the palpebra superior shading the cornea was alleviated in the two groups, but the observation group was superior to the control group (P<0.05).

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  • (PMID = 19127914.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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77. Hao J, Li SK, Kao WW, Liu CY: Gene delivery to cornea. Brain Res Bull; 2010 Feb 15;81(2-3):256-61
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  • [Title] Gene delivery to cornea.
  • This paper reviews the strategies of in vivo gene delivery to the cornea.
  • A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.
  • The introduction of foreign genes into intact corneal epithelium specifically requires more invasive procedures such as gene gun to disrupt the tight junction barrier and/or cell membranes.
  • The combination of iontophoresis and electroporation was found to be effective in delivering siRNA but not plasmid DNA into the corneal epithelium.
  • Nanocarriers such as polymeric micelles are promising methods of corneal gene delivery.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
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  • (PMID = 19560524.001).
  • [ISSN] 1873-2747
  • [Journal-full-title] Brain research bulletin
  • [ISO-abbreviation] Brain Res. Bull.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY15181; United States / NEI NIH HHS / EY / R01 EY015181; United States / NEI NIH HHS / EY / EY11845; United States / NEI NIH HHS / EY / R01 EY010556-09; United States / NEI NIH HHS / EY / R01 EY011845-07; United States / NEI NIH HHS / EY / R01 EY013755-07; United States / NEI NIH HHS / EY / EY010556-09; United States / NEI NIH HHS / EY / R01 EY010556; United States / NEI NIH HHS / EY / R01 EY013755; United States / NEI NIH HHS / EY / EY011845-07; United States / NEI NIH HHS / EY / R01 EY015181-05; United States / NEI NIH HHS / EY / EY013755-07; United States / NEI NIH HHS / EY / R01 EY011845; United States / NEI NIH HHS / EY / EY10556
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
  • [Other-IDs] NLM/ NIHMS128071; NLM/ PMC2823390
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78. Meier P: Combined anterior and posterior segment injuries in children: a review. Graefes Arch Clin Exp Ophthalmol; 2010 Sep;248(9):1207-19
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  • 1) comprehensive secondary operation for internal reconstruction, 2) encircling buckle surgery, 3) management of the lens, 4) use of a temporary keratoprosthesis, 5) endophthalmitis, and 6) late complications, e.g., secondary glaucoma, secondary strabismus, leukoma cornea, and phthisis bulbi.

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  • (PMID = 20512348.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 79
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79. Tu KL, Ibrahim M, Kaye SB: Spontaneous resolution of descemet membrane detachment after deep anterior lamellar keratoplasty. Cornea; 2006 Jan;25(1):104-6
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  • METHODS: A 77-year-old woman with bilateral anterior corneal stromal scarring underwent a right deep lamellar keratoplasty with the Melles technique.
  • One year after deep lamellar keratoplasty, the donor cornea was clear, and best corrected visual acuity in the right eye was 20/40 with -2.75/+2.50 x 55.
  • [MeSH-major] Corneal Diseases / physiopathology. Corneal Transplantation / adverse effects. Descemet Membrane / physiopathology. Postoperative Complications

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  • (PMID = 16331050.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Xhauflaire-Uhoda E, Piérard GE, Quatresooz P: The skin landscape following nonoptical capacitance imaging. Am J Clin Dermatol; 2010;11(2):89-94
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  • Skin capacitance is an electrical property measurable at the level of the stratum corneum.
  • [MeSH-major] Electric Capacitance. Skin / metabolism. Skin Diseases / diagnosis

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  • (PMID = 20141229.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Surface-Active Agents; Z4152N8IUI / Silicon
  • [Number-of-references] 34
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81. Sarnoff DS, Saini R: Multiple nonmelanoma skin cancers in a patient with epidermolytic hyperkeratosis on long-standing retinoid therapy. J Drugs Dermatol; 2008 May;7(5):475-8
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  • Epidermolytic hyperkeratosis is a rare genetic disorder of keratinization.
  • In childhood, patients are erythrodermic and have a compromised stratum corneum, replaced with generalized hyperkeratosis as the patients age.

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  • (PMID = 18505142.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoids
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82. Mustoe TA: Evolution of silicone therapy and mechanism of action in scar management. Aesthetic Plast Surg; 2008 Jan;32(1):82-92
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  • The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts.

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  • (PMID = 17968615.001).
  • [ISSN] 0364-216X
  • [Journal-full-title] Aesthetic plastic surgery
  • [ISO-abbreviation] Aesthetic Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Silicone Gels
  • [Number-of-references] 44
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83. Choi SK, Kim JH, Lee D, Moon NJ: Successful treatment of superficial corneal irregularity by lamellar keratectomy using the femtosecond laser. Ophthalmic Surg Lasers Imaging; 2010;41 Online:e1-4
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  • [Title] Successful treatment of superficial corneal irregularity by lamellar keratectomy using the femtosecond laser.
  • The authors report successful vision restoration after cataract surgery using a femtosecond laser in a patient with superficial corneal irregularity.
  • A 62-year-old man with corneal irregularity and a cataract in the left eye was referred for treatment.
  • The superficial corneal opacity causing the irregularity was mainly located within the superficial anterior cornea.
  • To acquire a stable keratometric value, which is important for accurate calculation of intraocular lens power, lamellar keratectomy using a femtosecond laser (IntraLase; AMO, Irvine, CA) was performed to smooth the cornea surface.
  • Postoperatively, corneal smoothness was restored and a stable keratometric value was acquired.
  • The femtosecond laser may be an effective surgical tool for patients with superficial corneal irregularity and cataracts.
  • [MeSH-major] Cataract / complications. Corneal Diseases / complications. Corneal Diseases / surgery. Laser Therapy. Ophthalmologic Surgical Procedures

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21053869.001).
  • [ISSN] 1938-2375
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Stanila A, Mihai E, Saceleanu A, Teodoru A: [The therapeutic contact lens--advantages and limits]. Oftalmologia; 2006;50(2):51-5
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  • [Transliterated title] Lentila de contact terapeutică--avantaje si limite.
  • RESULTS AND DISCUSSIONS: The main positive effects of the TCL were: relief of pain, improving of re-epithelization, the tectonic effect, mechanic protection and hydratation of the cornea, visual improving and the permitting of the binocularity.
  • The limits of the TCL are related to: susceptibility of infections, non adaptation or loosing of the lens in irregularity of the cornea.
  • [MeSH-major] Contact Lenses. Corneal Diseases / therapy

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  • (PMID = 16927759.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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85. Hariharan S, Janoria KG, Gunda S, Zhu X, Pal D, Mitra AK: Identification and functional expression of a carrier-mediated riboflavin transport system on rabbit corneal epithelium. Curr Eye Res; 2006 Oct;31(10):811-24
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  • [Title] Identification and functional expression of a carrier-mediated riboflavin transport system on rabbit corneal epithelium.
  • PURPOSE: To investigate the functional expression of a carrier-mediated transport mechanism for riboflavin (vitamin B2) across cultured rabbit primary corneal epithelial cells (rPCECs) and intact rabbit cornea.
  • The secondary objective was to understand the physiological significance behind the presence of such a transport system for riboflavin on the apical side of the corneal epithelium.
  • Transport of [3H]riboflavin across rabbit cornea was also saturable at higher concentration and energy dependent but Na+ independent.
  • Substrate specificity studies across intact rabbit cornea produced results similar to the uptake studies in cultured rPCECs.
  • CONCLUSIONS: Results suggest the presence of a specialized, high-affinity transport mechanism for riboflavin that is expressed on the apical side of rabbit corneal epithelium and may in turn be responsible for influx of riboflavin from tears to cornea.
  • [MeSH-major] Epithelium, Corneal / metabolism. Membrane Transport Proteins / metabolism. Riboflavin / pharmacokinetics

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  • (PMID = 17050273.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY 09171-12; United States / NEI NIH HHS / EY / R01 EY 10659-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Membrane Transport Proteins; 0 / riboflavin-binding protein; Q13SKS21MN / 2,4-Dinitrophenol; SML2Y3J35T / Colchicine; TLM2976OFR / Riboflavin
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86. Kaye S, Choudhary A: Herpes simplex keratitis. Prog Retin Eye Res; 2006 Jul;25(4):355-80
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  • Primary infection may involve an ocular or non-ocular site, following which latency might be established principally in the trigeminal ganglion but also in the cornea.
  • Visual morbidity results from recurrent keratitis, which leads to corneal scarring, thinning and neovascularisation.
  • Although, recurrent disease may potentially occur through anterograde axonal spread from the trigeminal ganglion to the cornea, recent evidence suggests that HSV-1 in the cornea may be another source of recurrent disease.
  • Herpetic stromal disease is due to the immune response to virus within the cornea and the ability of the strain to cause corneal stromal disease is correlated with its ability to induce corneal vascularisation.
  • The pathogenesis of corneal scarring and vascularisation is uncertain but appears to be a complex interaction of various cytokines, chemokines and growth factors either brought in by inflammatory cells or produced locally in response to HSV-1 infection.
  • Elucidating their roles in corneal scarring and vascularisation may lead to improved therapies for HSK.
  • [MeSH-minor] Animals. Cornea / metabolism. Cornea / pathology. Cornea / virology. Corneal Neovascularization / etiology. Corneal Neovascularization / pathology. Genes, Viral / genetics. Herpesvirus 1, Human / genetics. Humans

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  • (PMID = 16807055.001).
  • [ISSN] 1350-9462
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 258
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87. Olivry T, Linder KE: Dermatoses affecting desmosomes in animals: a mechanistic review of acantholytic blistering skin diseases. Vet Dermatol; 2009 Oct;20(5-6):313-26
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  • In superficial pustular dermatophytosis of dogs and horses, Trichophyton hyphae colonize the stratum corneum, and acantholysis presumably develops because of proteases secreted by the dermatophytes.

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  • (PMID = 20178467.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 61
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88. Zhang CF, Yang ZL, Luo JB: [Effects of D-limonene and L-limonene on transdermal absorption of ligustrazine hydrochloride]. Yao Xue Xue Bao; 2006 Aug;41(8):772-7
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  • The peak shift and peak areas of C-H stretching vibration absorption were estimated by Fourier transform-infrared (FTIR).
  • Morphological changes in the stratum corneum (SC) treated with enhancers were observed by a scanning electron microscope (SEM) and apparent density, a new concept, was proposed to estimate the desquamated extent of SC for the first time.
  • The FTIR results revealed that the shift and decreased peak area of C-H stretching vibrations in the SC lipids were dependent on the enhancers.

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  • (PMID = 17039786.001).
  • [ISSN] 0513-4870
  • [Journal-full-title] Yao xue xue bao = Acta pharmaceutica Sinica
  • [ISO-abbreviation] Yao Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclohexenes; 0 / Pyrazines; 0 / Terpenes; 9MC3I34447 / limonene; V80F4IA5XG / tetramethylpyrazine
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89. Minor J, Dunstan R, Guyon R, André C, Barnhart K, Credille K: Comparative sequence analysis and radiation hybrid mapping of the canine keratin 10 gene. DNA Seq; 2005 Apr;16(2):89-95
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  • The type I keratin, K10, is expressed in epidermal keratinocytes undergoing terminal differentiation to form the stratum corneum, a barrier essential for life.

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  • (PMID = 16147859.001).
  • [ISSN] 1042-5179
  • [Journal-full-title] DNA sequence : the journal of DNA sequencing and mapping
  • [ISO-abbreviation] DNA Seq.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY318944
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / KRT10 protein, human; 147785-83-9 / Keratin-10; 68238-35-7 / Keratins
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90. Svane-Knudsen V, Rasmussen G, Ottosen PD: The distribution of free calcium ions in the cholesteatoma epithelium. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):77-80
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  • The concentration declined precipitously in the stratum corneum.

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  • (PMID = 14963721.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calcium Channels
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91. Tomita Y, Akiyama M, Shimizu H: Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis. Exp Dermatol; 2005 Aug;14(8):619-24
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  • [Title] Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis.
  • To determine any correlation between the stratum corneum barrier function and the phenotypic severity of congenital ichthyosis, we studied stratum corneum hydration, flexibility, thickness and transepidermal water loss (TEWL) in patients with congenital ichthyosis.
  • Stratum corneum hydration, thickness and flexibility were measured using a Corneometer ASA-M2.
  • The stratum corneum thickness was also examined using a skin biopsy technique.
  • Stratum corneum hydration and flexibility were significantly reduced in both congenital ichthyosis patient groups.
  • Stratum corneum thickness was significantly increased in both groups.
  • In the patient group with non-bullous congenital ichthyosis, significant negative correlations were confirmed between the VAS score and stratum corneum hydration and between the VAS score and flexibility.
  • A significant, positive correlation was also observed between the VAS score and stratum corneum thickness.
  • We conclude that stratum corneum hydration, flexibility and thickness measured by the corneometer, and TEWL on the arm may be a useful indicator of the severity of ichthyosis phenotype.
  • [MeSH-major] Epidermis / physiology. Hyperkeratosis, Epidermolytic / diagnosis. Ichthyosis / diagnosis. Ichthyosis / pathology. Ichthyosis, Lamellar / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Phenotype. Skin / pathology. Skin Absorption. Skin Diseases / diagnosis. Skin Physiological Phenomena

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  • (PMID = 16026584.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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92. Mohammadpour M, Jabbarvand M, Javadi MA: Focal corneal decompensation after filtering surgery with mitomycin C. Cornea; 2007 Dec;26(10):1285-7
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  • [Title] Focal corneal decompensation after filtering surgery with mitomycin C.
  • PURPOSE: To report a case with focal corneal decompensation after filtering surgery with inadvertent inadequate irrigation of mitomycin C (MMC).
  • The primary diagnosis was idiopathic bilateral granulomatous anterior uveitis.
  • The IOP was controlled without medications; however; the inferior third of the cornea was edematous because of severe endothelial dysfunction.
  • CONCLUSIONS: Inadequate irrigation of MMC during filtering surgery can cause focal corneal decompensation.
  • [MeSH-major] Alkylating Agents / administration & dosage. Corneal Edema / etiology. Glaucoma / drug therapy. Glaucoma / surgery. Mitomycin / administration & dosage. Trabeculectomy / adverse effects

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  • (PMID = 18043196.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkylating Agents; 50SG953SK6 / Mitomycin
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93. Fleiszig SM: The Glenn A. Fry award lecture 2005. The pathogenesis of contact lens-related keratitis. Optom Vis Sci; 2006 Dec;83(12):866-73
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  • Bacterial infection of the cornea is a rare, but sight-threatening, complication of contact lens wear that was first reported shortly after soft lenses were introduced onto the market in the 1970s.
  • [MeSH-minor] Awards and Prizes. Cornea / pathology. Humans. Incidence. Risk Factors

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  • (PMID = 17164674.001).
  • [ISSN] 1040-5488
  • [Journal-full-title] Optometry and vision science : official publication of the American Academy of Optometry
  • [ISO-abbreviation] Optom Vis Sci
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01EY11221
  • [Publication-type] Lectures; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Chen CC, Yang CM, Hu FR, Lee YC: Penetrating ocular injury caused by venomous snakebite. Am J Ophthalmol; 2005 Sep;140(3):544-6
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  • Antivenom was provided, but facial swelling, periorbital ecchymoses, massive subconjunctival hemorrhage, severe corneal edema, and exophthalmos of the right eye were noted.
  • Pathologic examination of the excised cornea showed necrosis on the endothelial side.
  • [MeSH-minor] Adult. Animals. Antivenins / therapeutic use. Conjunctival Diseases / etiology. Corneal Edema / etiology. Crotalid Venoms / poisoning. Ecchymosis / etiology. Eye Evisceration. Eye Hemorrhage / etiology. Humans. Male

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  • (PMID = 16139013.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antivenins; 0 / Crotalid Venoms
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95. Mezentsev A, Mastyugin V, Seta F, Ashkar S, Kemp R, Reddy DS, Falck JR, Dunn MW, Laniado-Schwartzman M: Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels. J Pharmacol Exp Ther; 2005 Oct;315(1):42-50
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  • [Title] Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels.
  • Injury to the ocular surface induces the production of the corneal epithelial-derived 12-hydroxyeicosatetrienoic acid (12-HETrE), which exhibits stereospecific potent inflammatory and angiogenic properties and is formed by a cytochrome P450 (P450) enzyme, CYP4B1.
  • We have cloned the rabbit corneal CYP4B1 into the expression plasmid pIRES2-enhanced green fluorescent protein (EGFP) and examined the effect of CYP4B1 overexpression on corneal inflammation in vivo and limbal vessel sprouting ex vivo.
  • Cultured rabbit corneal epithelial cells transfected with pIRES2-EGFP-CYP4B1 metabolized arachidonic acid to 12-HETrE at a rate five times higher than that of pIRES2-EGFP-transfected cells (3.53 +/- 0.08 versus 0.62 +/- 0.10 nmol/h/10(6) cells; mean +/- S.E.M., n = 6, p < 0.05), indicating a functional expression of the CYP4B1.
  • Injection of either plasmid into the rabbit cornea resulted in EGFP fluorescence in the corneal epithelium.
  • However, corneal neovascularization, as measured by the length of penetrating blood vessels, was significantly greater in the corneas of eyes transfected with the pIRES2-CYP4B1 compared with pIRES2-EGFP.
  • Corneal-limbal explants from eyes transfected with pIRES2-CYP4B1 showed a marked angiogenic activity (46 +/- 10 versus 12 +/- 3 mm capillary length, n = 6, p < 0.05), which correlated with increased levels of 12-HETrE, the CYP4B1-derived angiogenic 12-hydroxyeicosanoid (0.93 +/- 0.18 versus 0.15 +/- 0.02 pmol/explant, n = 6, p < 0.05), and was inhibited (76 +/- 5%) by the P450 inhibitor 17-octadecynoic acid.
  • The results further implicate the corneal CYP4B1 as a component of the inflammatory and angiogenic cascade initiated by injury to the ocular surface and raise the possibility of a new therapeutic target for preventing corneal neovascularization, namely, the CYP4B1-12-HETrE system.
  • [MeSH-major] Aryl Hydrocarbon Hydroxylases / physiology. Cornea / enzymology. Corneal Neovascularization / etiology

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  • (PMID = 16009741.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY06513; United States / NIGMS NIH HHS / GM / GM31278
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 117346-20-0 / 12-hydroxy-5,8,14-eicosatrienoic acid; 7324-41-6 / 8,11,14-Eicosatrienoic Acid; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / cytochrome P-450 CYP4B1
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96. Kato S, Aoshima H, Saitoh Y, Miwa N: Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue. J Photochem Photobiol B; 2010 Jan 21;98(1):99-105
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  • UVA-caused corneum scaling and disruption of epidermis layer were detected by scanning electron microscopy.

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 20036139.001).
  • [ISSN] 1873-2682
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type IV; 0 / Fluorescent Dyes; 0 / Fullerenes; 0 / Liposomes; NP9U26B839 / fullerene C60
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97. Kaestli LZ, Wasilewski-Rasca AF, Bonnabry P, Vogt-Ferrier N: Use of transdermal drug formulations in the elderly. Drugs Aging; 2008;25(4):269-80
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  • Studies have shown that age-related changes in hydration and lipidic structure result in an increased barrier function of the stratum corneum only for relatively hydrophilic compounds.

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  • (PMID = 18361538.001).
  • [ISSN] 1170-229X
  • [Journal-full-title] Drugs & aging
  • [ISO-abbreviation] Drugs Aging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Number-of-references] 85
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98. Remeijer L, Duan R, van Dun JM, Wefers Bettink MA, Osterhaus AD, Verjans GM: Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues. J Infect Dis; 2009 Jul 1;200(1):11-9
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  • [Title] Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues.
  • BACKGROUND: We determined the prevalence and clinical consequences of herpes simplex virus (HSV) type 1 (HSV-1), HSV type 2 (HSV-2), and varicella-zoster virus (VZV) in cornea tissues obtained after penetrating keratoplasty (PKP) was performed.
  • The HSV-1 DNA load in the corneas of patients with HK correlated with age, the recurrence-free interval, cornea neovascularization, steroid treatment before PKP, and disease severity.
  • Graft survival was inversely correlated with the corneal HSV-1 DNA load in patients with HK.
  • CONCLUSIONS: The data presented in this study argue for the implementation of real-time HSV-1 PCR to analyze the excised corneas of patients with HK, to improve post-PKP diagnosis and therapy.
  • Screening of donor corneal tissues for herpesviruses is redundant to prevent newly acquired post-PKP HK.
  • [MeSH-major] Cornea / virology. DNA, Viral / genetics. Herpesvirus 1, Human / genetics
  • [MeSH-minor] Cohort Studies. Corneal Diseases / surgery. Corneal Diseases / virology. Corneal Transplantation / methods. Graft Survival. Herpes Zoster / surgery. Herpes Zoster / virology. Herpesvirus 2, Human / genetics. Herpesvirus 3, Human / genetics. Humans. Keratoplasty, Penetrating. Retrospective Studies. Treatment Failure

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  • [CommentIn] J Infect Dis. 2009 Jul 1;200(1):1-4 [19476431.001]
  • (PMID = 19476433.001).
  • [ISSN] 0022-1899
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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99. Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR: A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Br J Dermatol; 2010 Mar;162(3):647-54
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  • Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes.


100. Landin WE, Mun GC, Nims RW, Harbell JW: Use of the cytosensor microphysiometer to predict results of a 21-day cumulative irritation patch test in humans. Toxicol In Vitro; 2007 Sep;21(6):1165-73
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  • The acute toxicity of the mu phi assay can be compared to the chronic toxicity of the 21CIPT, which is based largely on the exposure of test agents to the epidermal cells, resulting in damage and penetration of the stratum corneum leading to cell toxicity.

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  • (PMID = 17475442.001).
  • [ISSN] 0887-2333
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Surface-Active Agents
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