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1. Sherer DM, Gorelick C, Wagreich A, Lee YC, Serur E, Zigalo A, Abulafia O: Sonographic findings of a large vulvar lipoma. Ultrasound Obstet Gynecol; 2007 Oct;30(5):786-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas of the vulva are rare benign tumors that consist of mature fat cells often interspersed with strands of fibrous connective tissue.
  • They arise from the vulvar fatty pads and present as soft, multilobulated subcutaneous neoplasms.
  • We present the sonographic findings of a large lipoma of the vulva, and demonstrate the contribution of topical application of a high-frequency transvaginal transducer in depicting lobular structural features, characteristic of this soft tissue tumor.
  • [MeSH-major] Lipoma / ultrasonography. Soft Tissue Neoplasms / ultrasonography. Vulvar Neoplasms / ultrasonography

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  • [Copyright] Copyright (c) 2007 ISUOG
  • (PMID = 17763338.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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2. Jo JH, Lee JH, Kim DC, Kim SH, Kwon HC, Kim JS, Kim HJ: A case of benign metastasizing leiomyoma with multiple metastasis to the soft tissue, skeletal muscle, lung and breast. Korean J Intern Med; 2006 Sep;21(3):199-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of benign metastasizing leiomyoma with multiple metastasis to the soft tissue, skeletal muscle, lung and breast.
  • Benign metastasizing leiomyoma (BML) is composed of well-differentiated smooth muscle cells and dense connective tissue.
  • BML affects middle-aged women who have had previous hysterectomies due to a histologically benign-appearing uterine leiomyoma.
  • We report here on a case of BML from the uterine leiomyoma in a 39-year-old woman that involved the soft tissues, skeletal muscles, lungs and breasts.
  • The microscopic findings of the breast and lung tumor were similar to those of the benign uterine leiomyoma.
  • We report here on a rare case of benign metastasizing uterine leiomyoma that involved the soft tissue, skeletal muscles, lungs and breasts, and we include a review of the relevant literature.
  • [MeSH-major] Breast Neoplasms / secondary. Leiomyoma / pathology. Lung Neoplasms / secondary. Muscle Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Uterine Neoplasms / pathology

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  • (PMID = 17017672.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 094ZI81Y45 / Tamoxifen
  • [Other-IDs] NLM/ PMC3890726
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3. Wu C, Wei Q, Utomo V, Nadesan P, Whetstone H, Kandel R, Wunder JS, Alman BA: Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res; 2007 Sep 1;67(17):8216-22
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  • [Title] Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.
  • Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface markers that identify mesenchymal progenitors.
  • We examined 29 mesenchymal tumors ranging from benign to high-grade sarcomas and identified SP cells in all but six samples.
  • There was a positive correlation between the percentage of SP cells and the grade of the tumor.
  • SP cells preferentially formed tumors when grafted into immunodeficient mice, and only cells from tumors that developed from the SP cells had the ability to initiate tumor formation upon serial transplantation.
  • Although SP cells are able to efflux rhodamine dye in addition to Hoechst 33342, we found that the ability to efflux rhodamine dye did not identify a population of cells enriched for tumor-initiating capacity.
  • Here, we identify a subpopulation of cells within a broad range of benign and malignant mesenchymal tumors with tumor-initiating capacity.
  • [MeSH-major] Neoplasms, Connective and Soft Tissue / pathology. Neoplastic Stem Cells / cytology
  • [MeSH-minor] Animals. Cell Proliferation. Disease Progression. Humans. Mice. Mice, Inbred NOD. Mice, SCID. Neoplasm Invasiveness. Neoplasm Transplantation / pathology. Transplantation, Heterologous

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  • (PMID = 17804735.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Koksel O, Demir Apaydin F, Ayan E, Demir M, Ozdulger A: Elastofibroma dorsi: Review of eight cases. Surg Today; 2010 May;40(5):423-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Elastofibroma dorsi (ED) is a rare, benign soft tissue tumor arising from connective tissue and usually found in the subscapular region.
  • We conducted this retrospective study to contribute to a better understanding of this tumor, the pathogenesis of which is still unclear.
  • The tumor was located on the right in two patients, on the left in one, and bilaterally in five.
  • CONCLUSIONS: We could not establish a relationship between the side of the dominant hand and the tumor location.
  • If this tumor becomes symptomatic, local excision is the best treatment; however, as malignant transformation has not been reported, follow-up is recommended for asymptomatic lesions.
  • [MeSH-major] Fibroma / surgery. Soft Tissue Neoplasms / surgery. Thoracic Neoplasms / surgery

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  • (PMID = 20425544.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Dreux N, Marty M, Chibon F, Vélasco V, Hostein I, Ranchère-Vince D, Terrier P, Coindre JM: Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases. Mod Pathol; 2010 Dec;23(12):1657-66

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases.
  • The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors.
  • Given its implication in these tumors and particularly adipocytic tumors, and the availability of antibodies usable on paraffin-embedded tissues, we evaluated the immunohistochemical expression of this gene in a series of 1052 mesenchymal tumors.
  • We thus analyzed 880 cases on tissue microarray and 182 cases on whole sections (211 adipocytic tumors, 628 sarcomas, 213 benign mesenchymal tumors, and 10 normal adipose tissues).
  • A nuclear immunostaining was detected in 86% of conventional and intramuscular lipomas, in 86% of well-differentiated liposarcomas and in 67% of dedifferentiated liposarcomas, as opposed to 16% of other benign adipose tumors and to 15% of non-well-differentiated liposarcoma/dedifferentiated liposarcoma sarcomas.
  • Among benign mesenchymal tumors and lesions, it was detected in 90% of nodular fasciitis and in 88% of benign fibrous histiocytomas with respective specificities of 85 and 100%, and in 90% of aggressive angiomyxoma, contrary to other vulvovaginal tumor types, which expressed HMGA2 only rarely.
  • The normal adipose tissue was always negative for HMGA2.
  • Although not specific, immunohistochemical detection of the HMGA2 protein is helpful for the distinction of normal adipose tissue from well-differentiated lesions, particularly on biopsy or on re-excision.
  • Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. HMGA2 Protein / biosynthesis. Neoplasms, Connective and Soft Tissue / diagnosis. Neoplasms, Connective and Soft Tissue / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis

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  • (PMID = 20834238.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein
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7. Hoseini AT, Razavi SM, Khabazian A: Lipoma in oral mucosa: two case reports. Dent Res J (Isfahan); 2010;7(1):41-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoma is a common tumor of soft tissue.
  • Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal por-tions of extremities.
  • The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor.
  • Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions (mucocele and mixed tumor) might be included in differential diagnosis.
  • We present two cases of oral lipoma in unusual locations: one in junction of soft and hard palate and the other in tongue.

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  • (PMID = 21448446.001).
  • [ISSN] 2008-0255
  • [Journal-full-title] Dental research journal
  • [ISO-abbreviation] Dent Res J (Isfahan)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3065337
  • [Keywords] NOTNLM ; Differential diagnosis / Lipoma / Pathology
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8. Kim EY, Choe YH, Sung K, Park SW, Kim JH, Ko YH: Multidetector CT and MR imaging of cardiac tumors. Korean J Radiol; 2009 Mar-Apr;10(2):164-75
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  • In the diagnosis of cardiac tumors, the use of MDCT and MRI can help differentiate benign from malignant masses.
  • Especially, the use of MDCT is advantageous in providing anatomical information and MRI is useful for tissue characterization of cardiac masses.
  • Knowledge of the characteristic MRI findings of benign cardiac tumors or thrombi can be helpful to avoid unnecessary surgical procedures.
  • [MeSH-minor] Contrast Media / administration & dosage. Electrocardiography. Hemangioma / pathology. Humans. Lymphoma / pathology. Neoplasms, Connective and Soft Tissue / pathology. Papilloma / pathology

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  • (PMID = 19270863.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 26
  • [Other-IDs] NLM/ PMC2651440
  • [Keywords] NOTNLM ; Cardiac tumor / Magnetic resonance (MR) / Multidetector CT
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9. Warzecha J, Kamand A, Daecke W, Meurer A: [Benign soft tissue tumors in orthopedics]. Orthopade; 2010 Dec;39(12):1171-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign soft tissue tumors in orthopedics].
  • For the most part soft tissue tumors are benign.
  • The course of even benign tumors is sometimes complicated.
  • Benign soft tissue tumors are subdivided according to the current WHO classification from 2002.
  • They are classified by the tissue they mimick.
  • Some benign soft tissue tumors occur in the context of a syndrome, leading to multiple tumors.
  • In these cases there is the threat of a tumor becoming malignant (neurofibromatosis, Maffucci syndrome).
  • [MeSH-major] Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Connective Tissue / pathology. Connective Tissue / surgery. Diagnosis, Differential. Early Diagnosis. Female. Fibroma / diagnosis. Fibroma / pathology. Fibroma / surgery. Hemangioma / diagnosis. Hemangioma / pathology. Hemangioma / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Humans. Lipoma / diagnosis. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Prognosis

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  • (PMID = 21107807.001).
  • [ISSN] 1433-0431
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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10. van de Rijn M, Fletcher JA: Genetics of soft tissue tumors. Annu Rev Pathol; 2006;1:435-66
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  • [Title] Genetics of soft tissue tumors.
  • Sarcomas form a highly diverse group of rare tumors that are derived from connective tissue.
  • More than 100 different malignant and benign soft tissue neoplasms can be recognized by histologic examination.
  • Few diagnostic markers exist, and the cell of origin for many soft tissue tumors is unknown.
  • For example, the success of the treatment of gastrointestinal stromal tumor with Imatinib has led to an increased effort to find targeted therapies for other malignancies.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Regulation, Neoplastic. Sarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 18039122.001).
  • [ISSN] 1553-4006
  • [Journal-full-title] Annual review of pathology
  • [ISO-abbreviation] Annu Rev Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 144
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11. Subhas N, Bui KL, Sundaram M, Ilaslan H, Recht MP: Incidental tumor and tumor-like lesions around the knee. Semin Musculoskelet Radiol; 2009 Dec;13(4):353-70
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  • [Title] Incidental tumor and tumor-like lesions around the knee.
  • Encountering an incidental tumor or tumor-like lesion during a routine magnetic resonance imaging (MRI) of the knee is not uncommon.
  • By far, the majority of these lesions are benign and many of them have characteristic appearances on MRI to allow a confident diagnosis.
  • The most common, and some less common, but important incidental lesions will be discussed including bone lesions (bone cysts, subchondral fractures, enchondromas, non-ossifying fibromas, "tug" lesions, osteochondromas, bone infarcts, and prominent red marrow) and soft tissue lesions (synovial hemangiomas, intracapsular chondromas, bursae, synovitis, soft-tissue cysts, hematomas, heterotopic ossification, vascular lesions and normal variants).
  • [MeSH-major] Bone Diseases / pathology. Incidental Findings. Joint Diseases / pathology. Knee Joint / pathology. Magnetic Resonance Imaging / methods. Neoplasms, Connective Tissue / pathology
  • [MeSH-minor] Bone Cysts / pathology. Bursa, Synovial / pathology. Humans. Synovial Membrane / pathology

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  • [Copyright] (c) Thieme Medical Publishers.
  • (PMID = 19890803.001).
  • [ISSN] 1098-898X
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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12. Liu YJ, Wang Y, Li ZL, Wang ZG, Wei M, Cai X, Xue J, Zhou M, Li HP, Zhu JL: [The value of arthroscopic minimally invasive surgery in diagnosis and treatment of benign bone and joint tumors]. Zhonghua Yi Xue Za Zhi; 2007 Mar 20;87(11):751-3
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  • [Title] [The value of arthroscopic minimally invasive surgery in diagnosis and treatment of benign bone and joint tumors].
  • OBJECTIVE: To approach the values of arthroscopic minimally invasive surgery (MIS) in diagnosis and treatment of benign bone and joint tumors.
  • METHOD: 20 cases of benign bone and joint tumors were diagnosed and treated by arthroscopic MIS.
  • In the treatments of distal femoral and calcaneal benign tumors, firstly, Kirschner wires were drilled into the pathological regions under the monitor of C-arm; then 6 mm diameter hollow drills were drilled follow the guide Kirschner wires and run-through the opposite side of cortical bone; then the arthroscope was inserted to check-up the pathological regions, then curettes or bite clamps were inserted from the opposite side to clean up tumor tissues; finally, 8 of the 13 were embedded with allograft gelsiccation bone, other 6 were embedded with carbonate hydroxyapatite cement.
  • One case of distal tibia epidermoid cyst were removed under arthroscope and filled with allograft bone.
  • 6 soft connective tissue tumors in knee articular cavities were removed under the monitor of arthroscope.
  • RESULT: According to pathological reports, 6 were yellow pigments tumors in knee articular cavities, 4 were osteoid osteomas of femoral bones, 3 were osteofibrous dysplasias, 2 were nonossifying fibromas, 4 were bone cysts of calcaneuses, one was distal tibia epidermoid cyst.
  • CONCLUSION: It is an accurate, minimally invasive and easy to manipulate technology to treat benign bone and joint tumors with the monitor of arthroscope.
  • [MeSH-major] Arthroscopes. Bone Neoplasms / surgery. Knee Joint. Minimally Invasive Surgical Procedures / methods
  • [MeSH-minor] Adult. Bone Cysts / surgery. Epidermal Cyst / surgery. Female. Humans. Male. Treatment Outcome

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  • (PMID = 17565843.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • [Title] Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Because non-AML/non-LAM PEComas are extremely rare and their natural history and prognostic features undefined, we present our experience with 26 PEComas of soft tissue and the gynecologic tract, the largest series to date.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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14. Song SY, Noh JH, Lee SJ, Son HJ: Bronchogenic cyst of the stomach masquerading as benign stromal tumor. Pathol Int; 2005 Feb;55(2):87-91
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  • [Title] Bronchogenic cyst of the stomach masquerading as benign stromal tumor.
  • At the time of surgery, a soft 1.7 cm nodule was found in the lesser curvature side just below the gastroesophageal junction, and a gelatinous mass was protruded from the nodule during the resection.
  • Microscopically, the gastric subserosa showed cystic structures lined by pseudostratified ciliated columnar epithelium, seromucinous gland, connective tissue and complete layers of smooth muscle bundles.

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  • (PMID = 15693855.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Policarpio-Nicolas ML, Covell J, Bregman S, Atkins K: Fine needle aspiration cytology of clear cell "sugar" tumor (PEComa) of the lung: report of a case. Diagn Cytopathol; 2008 Feb;36(2):89-93
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  • [Title] Fine needle aspiration cytology of clear cell "sugar" tumor (PEComa) of the lung: report of a case.
  • PEComa (clear cell "sugar" tumor) of the lung is a rare benign tumor of the lung probably arising from the perivascular epithelioid cells (PECs).
  • In this case report, the clinical, cytologic and immunohistochemical features clear cell "sugar" tumor of the lung are discussed and compared with the previously published literature.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Neoplasms, Connective and Soft Tissue / diagnosis. Neoplasms, Connective and Soft Tissue / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181192.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9005-79-2 / Glycogen
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16. Policarpio-Nicolas ML, Abbott TE, Dalkin AC, Bennett-Wick J, Frierson HF Jr: Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature. Diagn Cytopathol; 2008 Feb;36(2):115-9
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  • [Title] Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature.
  • Oncogenic (tumor-induced) osteomalacia is a rare paraneoplastic syndrome of phosphate wasting that is frequently associated with phosphaturic mesenchymal tumor (PMT).
  • As the cytologic features of this tumor apparently have not been reported, we describe the fine-needle aspiration (FNA) findings for PMT that arose from the gluteal soft tissue in a patient with hypophosphatemia and multiple fractures secondary to osteomalacia.
  • The differential diagnosis included a variety of benign and malignant spindle cell neoplasms such as monophasic synovial sarcoma, leiomyoma, peripheral nerve sheath tumor, fibrosarcoma, and, less likely, metastatic melanoma and sarcomatoid carcinoma.
  • The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neoplasms, Connective and Soft Tissue / diagnosis. Phosphates / urine

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181193.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphates
  • [Number-of-references] 21
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17. Erdas E, Licheri S, Pinna G, Gerosa C, Ragazzo G: [Elastofibroma dorsi: case report and review of the literature]. G Chir; 2006 Oct;27(10):372-6

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  • Elastofibroma dorsi (ED) is a rare, benign, often bilateral lesion of the thoracic wall, occurring most commonly in the infra-scapular region beneath the muscular tissue, generally found in elderly women.
  • Whether ED should be considered as a true neoplasm or merely as a reaction of connective tissue to repetitive minor trauma is still debated.
  • ED has characteristic features but a low incidence and is therefore not always easily distinguished from other benign and malignant soft-tissue tumors.
  • Nonetheless, marginal surgical excision was performed and the tumor was histologically diagnosed as ED.
  • As it is a benign lesion, surgical treatment is recommended only in symptomatic cases or if a large swelling is present.
  • [MeSH-major] Elastic Tissue / pathology. Fibroma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17147850.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 28
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18. Lee HW, Han SS, Kang J, Lee MW, Choi JH, Moon KC, Koh JK: Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? J Cutan Pathol; 2006 Apr;33(4):323-6
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  • [Title] Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor?
  • Eccrine angiomatous hamartoma (EAH) is a rare, benign condition characterized histologically by increased numbers of eccrine elements, as well as numerous capillary channels.
  • We report a 35-year-old female patient with multiple, sudoriparous, subcutaneous nodules on the right foot, which showed typical histopathological findings of EAH, and vascular components of the tumor consisted of thin-walled dilated vascular spaces intermixed with spindle cells and some histiocytoid endothelial cells representing spindle cell hemangioma (SCH).
  • [MeSH-major] Eccrine Glands / pathology. Foot. Hamartoma / diagnosis. Hemangioma / diagnosis. Neoplasms, Connective and Soft Tissue / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16630186.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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19. Edwards JR, Williams K, Kindblom LG, Meis-Kindblom JM, Hogendoorn PC, Hughes D, Forsyth RG, Jackson D, Athanasou NA: Lymphatics and bone. Hum Pathol; 2008 Jan;39(1):49-55
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  • [Title] Lymphatics and bone.
  • There is controversy regarding whether lymphatic vessels are present or absent in bone.
  • Although lymphangiomas have been described in bone, lymphatic vessels have not been identified morphologically with certainty in any other benign or malignant bone tumors or in normal human bone.
  • In this study, we determined by immunohistochemistry, using 2 specific lymphatic endothelial cell markers, LYVE-1 and podoplanin, whether lymphatics are present in normal bone and a wide range of primary and secondary bone neoplasms.
  • In normal bone, LYVE-1+/podoplanin+ lymphatic vessels were not identified in cortical or cancellous bone but were seen in connective tissue overlying the periosteum.
  • With the exception of lymphangioma, Gorham-Stout disease, and hemangioendothelioma, primary benign and malignant bone tumors (as well as secondary carcinomas) that were confined to bone did not contain lymphatic vessels.
  • Primary and secondary bone tumors that had extended through the bone cortex contained LYVE-1+/podoplanin+ lymphatic vessels that seemed to extend for a short distance from surrounding soft tissues into the tumor.
  • Three cases of osteosarcoma that had extended through the bone cortex and had lymph node metastases were all found to contain lymphatic vessels within the tumor.
  • These results indicate that the lymphatic circulation is unlikely to play a role in bone fluid transport in normal bone and that lymphatic vessels are absent from most primary and secondary tumors confined to bone.
  • These findings also suggest that lymphangiogenesis is not involved in the disease progression of most primary bone tumors and that carcinomatous metastasis to bone does not occur via lymphatics.
  • [MeSH-major] Bone Neoplasms / metabolism. Bone and Bones / anatomy & histology. Lymphatic Vessels / anatomy & histology. Membrane Glycoproteins / analysis. Vesicular Transport Proteins / analysis

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  • [CommentIn] Hum Pathol. 2009 Jan;40(1):143-4; author reply 144 [19027456.001]
  • (PMID = 17904616.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U137884182
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / LYVE1 protein, human; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Vesicular Transport Proteins
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20. Adachi Y, Horie Y, Kitamura Y, Nakamura H, Taniguchi Y, Miwa K, Fujioka S, Nishimura M, Hayashi K: CD1a expression in PEComas. Pathol Int; 2008 Mar;58(3):169-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC.
  • Recently the authors reported that benign clear cell sugar tumor of the lung, one of the PEComas, expressed CD1a.
  • Nineteen PEComas were obtained, which included angiomyolipoma of the kidney or liver, lymphangiomyomatosis of the uterus or lung and clear cell sugar tumor of the lung.
  • [MeSH-major] Antigens, CD1 / metabolism. Biomarkers, Tumor / metabolism. Epithelioid Cells / metabolism. Neoplasms, Connective and Soft Tissue / metabolism

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  • (PMID = 18251780.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen
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21. Marshall AE, Martin SE, Agaram NP, Chen JH, Horn EM, Douglas-Akinwande AC, Hattab EM: A 61-year-old woman with osteomalacia and a thoracic spine lesion. Brain Pathol; 2010 Mar;20(2):499-502
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  • Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) is a rare, largely benign, mesenchymal neoplasm almost invariably associated with oncogenic osteomalacia.
  • It is generally found in the soft tissue and bone of the extremities.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasms, Complex and Mixed / complications. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Complex and Mixed / pathology. Neoplasms, Connective Tissue / complications. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / pathology

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  • (PMID = 20438469.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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22. Liu PT: Radiological reasoning: Acutely painful swollen finger. AJR Am J Roentgenol; 2007 Mar;188(3 Suppl):S13-7
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  • CONCLUSION: Giant cell tumor of the tendon sheath is a slowly growing, benign tumor of the synovium that commonly presents as a painless nodular mass in the hand or wrist.
  • Also termed "localized nodular tenosynovitis," these tumors are the most common soft-tissue tumors of the hand.
  • [MeSH-major] Edema / pathology. Fingers / pathology. Giant Cell Tumors / diagnosis. Neoplasms, Connective Tissue / complications. Neoplasms, Connective Tissue / diagnosis. Pain / etiology. Tendons / pathology

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  • (PMID = 17312081.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Peterson NR, Summerlin DJ, Cordes SR: Multiple phosphaturic mesenchymal tumors associated with oncogenic osteomalacia: case report and review of the literature. Ear Nose Throat J; 2010 Jun;89(6):E11-5
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  • [Title] Multiple phosphaturic mesenchymal tumors associated with oncogenic osteomalacia: case report and review of the literature.
  • Oncogenic osteomalacia is a rare paraneoplastic syndrome that occurs secondary to tumor development in a variety of locations.
  • The most common causal tumor is phosphaturic mesenchymal tumor (PMT), a histologically benign lesion.
  • Despite resection of both tumors, the patient's signs and symptoms did not resolve, suggesting either incomplete tumor removal or the presence of another undetected tumor.
  • [MeSH-major] Bone Neoplasms / etiology. Hypophosphatemia, Familial / pathology. Mesenchymoma / etiology. Osteomalacia / complications. Tibia / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Neoplasms, Connective and Soft Tissue / pathology

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  • (PMID = 20556724.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 36
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24. Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY: Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S47-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases.
  • Non-lymphoid mesenchymal neoplasms of salivary gland origin are rare, accounting for 1.9-5% of major salivary gland tumors.
  • We describe the clinico-pathologic features of 18 cases of mesenchymal neoplasms of the major salivary glands experienced at Asan Medical Center, Seoul, Korea, from 1998 to 2004.
  • Mesenchymal neoplasms accounted for 3.4% of the total of 524 major salivary gland tumors.
  • Thirteen tumors were benign, constituting 3.5% of the total of 371 benign neoplasms.
  • Schwannomas were the most common benign tumors (six cases), followed by lipomas (three cases), plexiform neurofibroma, hemangioma, desmoid tumor, and solitary fibrous tumor (one each).
  • The malignant tumors consisted of one dermatofibrosarcoma protuberans, synovial sarcoma, leiomyosarcoma, pleomorphic liposarcoma and desmoplastic small round cell tumor each.
  • Genetic analysis for fusion transcripts was conclusive in the diagnosis of desmoplastic small round cell tumor, which is extremely rare at this location.
  • Pre-operative imaging study and fine needle aspiration cytology had limitations in prediction of the mesenchymal nature of the tumors, due to either low index of suspicion, similarities to mixed tumors, or specimen inadequacy.
  • Awareness of the development of various mesenchymal tumors in the major salivary glands could increase the accuracy of preoperative and postoperative diagnosis, and therapeutic efficacy.
  • [MeSH-major] Neoplasms, Connective and Soft Tissue / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • (PMID = 17934743.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Bord A, Valsky DV, Yagel S: Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. Prenat Diagn; 2006 Nov;26(11):1065-7
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  • BACKGROUND: Skin tags, or acrochordons, are benign, soft, fleshy tumors that are composed of hyperplastic epidermis covering a dermal connective tissue stalk.
  • METHODS: Case report of a congenital perineal skin tag that presented as a perineal tumor during second-trimester sonographic scan at 23 weeks' gestation.

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  • (PMID = 16952203.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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26. Jung SN, Shin JW, Kwon H, Yim YM: Fibrolipoma of the tip of the nose. J Craniofac Surg; 2009 Mar;20(2):555-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibrolipoma is a rare benign tumor that usually presents as an asymptomatic, slowly growing mass with a firm or soft consistency clinically.
  • Histopathologic findings show the proliferation of normal mature fat and fibrous tissue.
  • [MeSH-minor] Adipocytes / pathology. Collagen. Connective Tissue / pathology. Eosinophilia / pathology. Follow-Up Studies. Humans. Male. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19305254.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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27. Goh BK, Chow PK, Kesavan S, Yap WM, Wong WK: Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate? J Surg Oncol; 2008 Apr 1;97(5):388-91
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Present surgical opinion is divided regarding the optimal method for the treatment of duodenal gastrointestinal stromal tumor (GIST) with some supporting the selective use of limited resection (LR) versus others who prefer pancreaticoduodenectomy (PD).
  • RESULTS: There were 15 GISTs, 1 leiomyosarcoma and 6 other non-GIST benign submucosal tumors.
  • Comparison between GIST and other benign tumors demonstrated that size was the only statistically significant distinguishing factor [8.5 (range, 2.5-18.0) vs. 2.5 (range, 1.5-8.0) cm, P = 0.014].
  • CONCLUSION: Benign non-GIST tumors may be distinguished from duodenal GIST as they are smaller in size.
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Connective and Soft Tissue / mortality. Neoplasms, Connective and Soft Tissue / pathology. Neoplasms, Connective and Soft Tissue / surgery. Paraganglioma / mortality. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Time Factors

  • Genetic Alliance. consumer health - Gastrointestinal Stromal Tumors.
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  • [Copyright] (Copyright) 2008 Wiley-Liss, Inc.
  • (PMID = 18163461.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Iatrou IA, Theologie-Lygidakis N, Leventis MD: Case report: desmoplastic fibroma of the mandible in a child presenting with TMJ dysfunction. Eur Arch Paediatr Dent; 2008 Jun;9(2):105-8
MedlinePlus Health Information. consumer health - Temporomandibular Joint Dysfunction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Desmoplastic fibroma of bone is a rare intraosseous benign but locally aggressive tumor of connective tissue origin.
  • Clinical and radiological examination revealed a tumor-like lesion of the mandible extending into the soft tissues, which on biopsy proved to be a desmoplastic fibroma.
  • TREATMENT: The surgical treatment included peripheral ostectomy of the mandible, via an intraoral approach, for the removal of the lesion and restoration of the bone defect with an iliac bone autograft.
  • Extended surgical removal of the tumor, with wide margins, proved to be the appropriate treatment.
  • [MeSH-minor] Bone Transplantation. Child. Follow-Up Studies. Humans. Male. Mandible / surgery. Osteotomy

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  • (PMID = 18534181.001).
  • [ISSN] 1818-6300
  • [Journal-full-title] European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur Arch Paediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Papadogeorgakis N, Petsinis V, Nikitakis N, Goutzanis L, Alexandridis C: Intramuscular myxoma of the masseter muscle. A case report. Oral Maxillofac Surg; 2009 Mar;13(1):37-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Myxomas are benign, locally infiltrative, connective tissue tumors that rarely occur in the head and neck region.
  • Computed tomography scan showed an intramasseter well-defined soft tissue mass.
  • After a preauricular approach, a circumscribed solid gelatinous tumor was excised with thin margins including adjacent muscle tissue.

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  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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