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1. Stürmer J, Mermoud A, Sunaric Mégevand G: [Trabeculectomy with mitomycin C supplemented with cross-linking hyaluronic acid: a pilot study]. Klin Monbl Augenheilkd; 2010 Apr;227(4):273-6
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  • [Transliterated title] Erste Erfahrungen mit einem retikulierten Hyaluronsäurepräparat bei der Trabekulektomie.
  • PATIENTS AND METHODS: In a non-randomised pilot study cross-linking hyaluronic acid (HealaFlow) was injected below the scleral flap and under the conjunctiva in 66 patients undergoing filtering surgery.
  • CONCLUSIONS: Injections of HealaFlow below the scleral flap and the conjunctiva at the end of the surgery along with intraoperative application of MMC showed promising IOP-lowering effects in trabeculectomy.

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20408072.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antibiotics, Antineoplastic; 0 / Cross-Linking Reagents; 0 / Drug Combinations; 50SG953SK6 / Mitomycin; 9004-61-9 / Hyaluronic Acid
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2. Zeppa L, Romano MR, Capasso L, Tortori A, Majorana MA, Costagliola C: Sutureless human sclera donor patch graft for Ahmed glaucoma valve. Eur J Ophthalmol; 2010 May-Jun;20(3):546-51
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  • PURPOSE: To report the safety and effectiveness of a sutureless human sclera donor patch graft covering the subconjunctival portion of glaucoma drainage implant tube to prevent its erosion throughout the overlying conjunctiva.
  • The anterior part of the tube was covered with human donor scleral graft and kept in place with fibrin glue (Tissue Coll) under the conjunctiva.
  • No conjunctival erosion over the AGV tube nor sign of endophthalmitis was recorded at any time during the follow-up period.
  • CONCLUSIONS: AVG implant surgery with sutureless human sclera donor patch graft represents an effective and relatively safe surgical procedure for complicated glaucomas, avoiding conjunctival erosions over the AGV tube.
  • [MeSH-major] Conjunctiva / surgery. Glaucoma / surgery. Glaucoma Drainage Implants. Prosthesis Implantation / methods. Sclera / transplantation. Suture Techniques

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  • (PMID = 20037905.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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3. Hoffman K, Videan EN, Fritz J, Murphy J: Diagnosis and treatment of ocular coccidioidomycosis in a female captive chimpanzee (Pan troglodytes): a case study. Ann N Y Acad Sci; 2007 Sep;1111:404-10
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  • [Title] Diagnosis and treatment of ocular coccidioidomycosis in a female captive chimpanzee (Pan troglodytes): a case study.
  • Subsequent development of a coccidioidal granuloma of the ventral conjunctiva and anterior uvea was noted over the next several months, distorting the lens, iris, pupil, and sclera and progressing to uveitis.
  • [MeSH-major] Coccidioidomycosis / diagnosis. Coccidioidomycosis / therapy. Eye / microbiology. Uveitis / diagnosis. Uveitis / therapy
  • [MeSH-minor] Animals. Coccidioides / metabolism. Conjunctivitis / diagnosis. Conjunctivitis / microbiology. Conjunctivitis / therapy. Conjunctivitis / veterinary. Female. Ketoconazole / therapeutic use. Models, Anatomic. Pan troglodytes

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  • (PMID = 17303834.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1U42RR15090-05
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] R9400W927I / Ketoconazole
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4. Mehta M, Fay A: Squamous cell carcinoma of the eyelid and conjunctiva. Int Ophthalmol Clin; 2009;49(1):111-21
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  • [Title] Squamous cell carcinoma of the eyelid and conjunctiva.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Conjunctival Neoplasms / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Survival Rate

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  • (PMID = 19125070.001).
  • [ISSN] 0020-8167
  • [Journal-full-title] International ophthalmology clinics
  • [ISO-abbreviation] Int Ophthalmol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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5. Jumblatt MM, Imbert Y, Young WW Jr, Foulks GN, Steele PS, Demuth DR: Glycoprotein 340 in normal human ocular surface tissues and tear film. Infect Immun; 2006 Jul;74(7):4058-63
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  • Lesser amounts of gp340 were detected in the cornea and conjunctiva.
  • Consistent with Western blot data, reverse transcription-PCR and real-time quantitative PCR showed that gp340 transcripts were abundant in lacrimal gland tissue and were also present in the cornea and conjunctiva.
  • Immunohistochemistry localized gp340 to the acinar cells of the lacrimal gland and the deeper layers of the conjunctival epithelium. gp340 was not detected in conjunctival goblet cells.

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  • (PMID = 16790779.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R03 EY015134; United States / NIDCR NIH HHS / DE / R01 DE014605; United States / NEI NIH HHS / EY / EY015636; United States / NEI NIH HHS / EY / EY015134; United States / NEI NIH HHS / EY / R01 EY010736; United States / NIDCR NIH HHS / DE / DE014605; United States / NEI NIH HHS / EY / R24 EY015636; United States / NEI NIH HHS / EY / EY10736; United States / NIDCR NIH HHS / DE / R01 DE012750
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agglutinins; 0 / Eye Proteins; 0 / Receptors, Immunologic; 0 / glycoprotein 340
  • [Other-IDs] NLM/ PMC1489741
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6. Wilson DP, Bowlin AK, Bavoil PM, Rank RG: Ocular pathologic response elicited by Chlamydia organisms and the predictive value of quantitative modeling. J Infect Dis; 2009 Jun 15;199(12):1780-9
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  • METHODS: Guinea pigs were inoculated in the conjunctiva with various infectious doses of Chlamydia caviae.
  • [MeSH-major] Chlamydia / pathogenicity. Chlamydia Infections / pathology. Conjunctiva / pathology. Conjunctivitis / pathology. Eye Infections, Bacterial / pathology

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  • (PMID = 19419335.001).
  • [ISSN] 0022-1899
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI54310
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Zola E, van der Meulen IJ, Lapid-Gortzak R, van Vliet JM, Nieuwendaal CP: A conjunctival mass in the deep superior fornix after a long retained hard contact lens in a patient with keloids. Cornea; 2008 Dec;27(10):1204-6
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  • [Title] A conjunctival mass in the deep superior fornix after a long retained hard contact lens in a patient with keloids.
  • A pseudoptosis and an impressive mass growing from the superior tarsal conjunctiva with a lot of mucous discharge were present in the left eye.
  • The previous history of dry eyes and chronic conjunctivitis led us to miss the diagnosis at the first visits, despite persisting complaints.
  • [MeSH-major] Conjunctival Diseases / complications. Conjunctival Diseases / etiology. Contact Lenses / adverse effects. Eyelid Diseases / complications. Eyelid Diseases / etiology. Keloid / complications

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  • (PMID = 19034144.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Ointments
  • [Number-of-references] 10
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8. Garrett Q, Xu S, Simmons PA, Vehige J, Flanagan JL, Willcox MD: Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium. Invest Ophthalmol Vis Sci; 2008 Nov;49(11):4844-9
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  • PURPOSE: The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested.
  • This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctival epithelium.
  • METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used for OCTN1 and OCTN2 mRNA expression in cultured human corneal-limbal epithelial (HCLE) or human conjunctival epithelial (HCjE) cells.
  • Immunofluorescence staining with polyclonal antibody against human OCTN1 or OCTN2 was performed to investigate transporter expression in ocular epithelial cells or rabbit corneal and conjunctival epithelium.
  • CONCLUSIONS: This report is the first to document OCTN1 and OCTN2 expression in human corneal and conjunctival epithelial cells.
  • [MeSH-major] Carnitine / metabolism. Conjunctiva / metabolism. Epithelial Cells / metabolism. Epithelium, Corneal / metabolism. Gene Expression. Organic Cation Transport Proteins / genetics. RNA, Messenger / genetics

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  • (PMID = 18641280.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organic Cation Transport Proteins; 0 / RNA, Messenger; 0 / SLC22A4 protein, human; 0 / SLC22A5 protein, human; S7UI8SM58A / Carnitine
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9. Kuzmanović Elabjer B, Busić M, Elabjer E: Retrospective clinical analysis of free conjunctival autograft in treatment of pterygia. Coll Antropol; 2008 Mar;32(1):303-6
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  • [Title] Retrospective clinical analysis of free conjunctival autograft in treatment of pterygia.
  • The paper is a clinical retrospective analysis of free conjunctival autograft in treatment of pterygia.
  • In period from 1998 until 2006, 47 patients with pterygia were operated using free conjunctival autograft.
  • Free autograft was taken from superotemporal conjunctiva.
  • Free conjunctival autograft was successfully taken in all patients.
  • In glaucoma patients, delayed healing of the cornea, conjunctival harvest area and the graft was noted.
  • Free conjunctival graft is a safe and effective method of pterygium surgery that produces only few complications and has low recurrence rate.
  • [MeSH-major] Conjunctiva / transplantation. Pterygium / surgery

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  • (PMID = 18494218.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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10. Tellier Z: Intravenous immunoglobulin in eye involvement. Clin Rev Allergy Immunol; 2005 Dec;29(3):295-306
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  • Ocular inflammation may affect all eye layers: conjunctiva, sclera, uvea, and orbital tissues.

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  • (PMID = 16391405.001).
  • [ISSN] 1080-0549
  • [Journal-full-title] Clinical reviews in allergy & immunology
  • [ISO-abbreviation] Clin Rev Allergy Immunol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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11. Murata M, Takanami T, Shimizu S, Kubota Y, Horiuchi S, Habano W, Ma JX, Sato S: Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF). Curr Eye Res; 2006 Feb;31(2):171-80
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  • Histological analysis displayed no particular tissue damage in the conjunctiva where siRNA was injected.

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  • (PMID = 16500768.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Double-Stranded; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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12. Lee E, Doyle E, Jenkins C: Trabeculectomy surgery augmented with intra-Tenon injection of mitomycin C. Acta Ophthalmol; 2008 Dec;86(8):866-70
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  • This technique involved injecting MC into the Tenon's layer during the procedure, rather than applying it directly to the under-surface of the conjunctiva.

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  • (PMID = 19086929.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin
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13. Lynch MI, Moraes LF, Malagueño E, Ferreira S, Cordeiro F, Oréfice F: [Clinical characteristics of 64 individuals carrying active posterior presumptively toxoplasmic uveitis, in Pernambuco]. Arq Bras Oftalmol; 2008 Jan-Feb;71(1):43-8
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  • [Transliterated title] Características clínicas de 64 indivíduos portadores de uveítis posterior activa presumiblemente toxoplásmica en Pernambuco.
  • Hyperemia of the conjunctiva was observed in 29.7% of the patients and alterations of the cornea in 51.6%.
  • [MeSH-major] Aqueous Humor / parasitology. Toxoplasmosis, Ocular / diagnosis. Uveitis, Posterior / parasitology. Visual Acuity

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  • (PMID = 18408836.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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14. Nagata T, Nabe T, Fujii M, Mizutani N, Kohno S: Effects of multiple dexamethasone treatments on aggravation of allergic conjunctivitis associated with mast cell hyperplasia. Biol Pharm Bull; 2008 Mar;31(3):464-8
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  • In addition, the number of mast cells in the conjunctiva was increased by multiple challenges.
  • Mast cells in the conjunctival tissue were detected by toluidine blue staining.
  • In conclusion, increased numbers of mast cells in the conjunctival tissue may be associated with the aggravation of allergic conjunctivitis symptoms.

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  • (PMID = 18310911.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Cry j I protein, Cryptomeria japonica; 0 / Glucocorticoids; 0 / Plant Proteins; 7S5I7G3JQL / Dexamethasone; 820484N8I3 / Histamine
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15. Fukushima A: Roles of T-cells in the development of allergic conjunctival diseases. Cornea; 2007 Oct;26(9 Suppl 1):S36-40
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  • [Title] Roles of T-cells in the development of allergic conjunctival diseases.
  • Massive infiltration of eosinophils is the typical histopathologic feature of severe forms of allergic conjunctival diseases (ACDs) such as vernal keratoconjunctivitis.
  • Therefore, my group studied the likely roles of immunocompetent cells bearing Ag-specific receptors in inducing conjunctival eosinophil infiltration in ACDs.
  • The transfer of Ag-primed splenocytes or T-cells, but not of Ag-specific IgE, induced conjunctival eosinophil infiltration.
  • We also showed that soon after EC induction by T-cell transfer, activated Ag-specific T-cells infiltrated the conjunctiva.
  • Moreover, when EC-developing animals were topically treated with the T-cell-specific immunosuppressants cyclosporin A and FK506, conjunctival eosinophil infiltration was abrogated.
  • In addition, only the transfer of Ag-specific type 2 helper T-cells (TH2 cells), but not of type 1 helper T-cells or CD8 T-cells, could induce conjunctival eosinophil infiltration.
  • Our data show that Ag-specific TH2 cells play a crucial role in inducing conjunctival eosinophil infiltration during the development of EC.
  • It is necessary to elucidate the roles that conjunctival residential cells and immunocompetent cells other than T-cells play in the conjunctival eosinophil infiltration of EC.
  • [MeSH-major] Conjunctiva / pathology. Conjunctivitis, Allergic / immunology. T-Lymphocytes / immunology

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  • (PMID = 17881914.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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16. Fathy FM, El-Barghathi A, El-Ahwal A, El-Bagar S: Study on human ophthalmomyiasis externa caused by Oestrus ovis larva, in Sirte-Libya: parasite features, clinical presentation and management. J Egypt Soc Parasitol; 2006 Apr;36(1):265-82, following 282
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  • The larva usually limits it's activity to the conjunctiva and cornea, but, penetration of the eye is a potential complication.
  • Important criteria for diagnosis were; sudden mobile foreign body sensation with abrupt itching and lacrimation occurring in endemic area, in warm months even without history of fly strike.
  • So, early diagnosis and treatment are essential to avoid complications.

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  • (PMID = 16605116.001).
  • [ISSN] 1110-0583
  • [Journal-full-title] Journal of the Egyptian Society of Parasitology
  • [ISO-abbreviation] J Egypt Soc Parasitol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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17. Khalfaoui T, Kria L, Anane R, Erraies K, Beltaief O, Mkannez G, Zhioua R, Ben Jilani S, Ouertani Meddeb A: [Expression of intercellular adhesion molecule type 1 in the conjunctiva of diabetic patients: a preliminary study]. J Fr Ophtalmol; 2006 Sep;29(7):783-8
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  • [Title] [Expression of intercellular adhesion molecule type 1 in the conjunctiva of diabetic patients: a preliminary study].
  • [Transliterated title] Expression de la molécule d'adhésion intercellulaire de type 1 au niveau de la conjonctive des patients diabétiques: une étude préliminaire.
  • The purpose of our investigation was to study the expression of intercellular adhesion molecule type 1 (ICAM-1) in the conjunctiva of diabetic patients without retinopathy in comparison with normal human conjunctiva.
  • PATIENTS AND METHODS: Fifteen conjunctival biopsies were obtained from diabetic patients without retinopathy.
  • The normal human conjunctiva were taken from five patients undergoing senile cataract surgery.
  • In the normal human conjunctiva, the expression of ICAM-1 was very low.
  • CONCLUSION: This preliminary study shows that ICAM-1 is present in the conjunctiva of diabetic patients without retinopathy and thus may add new insights into the pathogenesis of diabetic retinopathy.
  • [MeSH-major] Conjunctiva / metabolism. Diabetes Mellitus, Type 2 / metabolism. Intercellular Adhesion Molecule-1 / biosynthesis

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  • (PMID = 16988628.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 126547-89-5 / Intercellular Adhesion Molecule-1
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18. Nizam MH, Ruszymah BH, Chua KH, Ghafar NA, Hamzah JC: Ex vivo growth of rabbit bulbar, fornix and palpebral conjunctival epithelia in a serum-free and feeder layer-free culture system. Med J Malaysia; 2008 Jul;63 Suppl A:111-2
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  • [Title] Ex vivo growth of rabbit bulbar, fornix and palpebral conjunctival epithelia in a serum-free and feeder layer-free culture system.
  • This study was conducted to explore the feasibility of culturing conjunctiva epithelial cells in serum-free and feeder layer-free culture system with regard to the cell morphology and immunocytochemistry of the rabbit bulbar, fornix and palpebral conjunctiva epithelia.
  • The results showed that epithelium cells from all the three conjunctiva regions can be cultured in a serum-free and feeder layer-free environment.
  • These findings suggested that fornix was a better source of cells for the development of tissue engineered conjunctiva for future clinical application.
  • [MeSH-major] Conjunctiva / cytology. Corneal Diseases / surgery. Epithelium, Corneal / cytology

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  • (PMID = 19025010.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 68238-35-7 / Keratins
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19. Touzri RA, Mohamed Z, Khalil E, Ilhem MB, Insaf M, Bassima F, Amel MO: [Ocular malignancies of xeroderma pigmentosum: clinical and therapeutic features]. Ann Dermatol Venereol; 2008 Feb;135(2):99-104
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  • Blindness was noted in 3/26 (12%) eyes in patients without malignant tumour and in 10/38 (26%) eyes in patients with malignant tumour.
  • Lesions occur almost exclusively in the eyelids, conjunctiva, limbus and/or cornea.
  • The rapid regression of these tumours, particularly in the cornea and limbus, may cause blindness, emphasising the importance of early management and regular monitoring of patients in order to allow early diagnosis of this condition, thereby ensuring the least mutilant treatment possible.
  • [MeSH-minor] Adolescent. Adult. Blindness / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / surgery. Corneal Diseases / pathology. Corneal Diseases / surgery. Humans. Limbus Corneae / pathology. Photophobia / etiology. Prospective Studies. Retrospective Studies

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  • (PMID = 18342089.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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20. Yospaiboon Y, Wongwai P, Ratanapakorn T, Sinawat S: Translimbal fixation of posterior chamber lenses. J Med Assoc Thai; 2005 Nov;88 Suppl 9:S77-81
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  • An inferior groove was made to bury the suture knot and was sutured closed to prevent the knot erosion through the conjunctiva.
  • [MeSH-major] Cataract / diagnosis. Cataract Extraction / methods. Lens Implantation, Intraocular / methods. Limbus Corneae / surgery

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  • (PMID = 16681056.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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21. Ha SW, Lee JM, Jeung WJ, Ahn HB: Clinical effects of conjunctiva-Müller muscle resection in anophthalmic ptosis. Korean J Ophthalmol; 2007 Jun;21(2):65-9
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  • [Title] Clinical effects of conjunctiva-Müller muscle resection in anophthalmic ptosis.
  • PURPOSE: To evaluate the clinical effects of conjunctiva-Muller muscle resection through conjunctival incision in anophthalmic patients with mild ptosis.
  • METHODS: Conjunctiva-Müller muscle resection was performed by one surgeon in 8 patients (8 eyes) who had received evisceration or enucleation and responded to 10% phenylephrine solution to correct ptosis.
  • The Müller muscle was resected 7.5 to 9 mm through conjunctival incision during surgery to match the MRD 1 of sound eye.
  • CONCLUSIONS: Conjunctiva-Müller muscle resection is one of the effective methods of correcting mild ptosis in anophthalmic patients.
  • [MeSH-major] Anophthalmos / complications. Blepharoptosis / surgery. Conjunctiva / surgery. Facial Muscles / surgery. Ophthalmologic Surgical Procedures / methods

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  • [Cites] Ophthal Plast Reconstr Surg. 2000 Mar;16(2):94-100 [10749155.001]
  • [Cites] Ophthal Plast Reconstr Surg. 2002 Nov;18(6):426-9 [12439055.001]
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  • [Cites] Am J Ophthalmol. 1982 May;93(5):647-51 [7081363.001]
  • (PMID = 17592234.001).
  • [ISSN] 1011-8942
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2629698
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22. Stein JD, Antonyshyn OM: Aesthetic eyelid reconstruction. Clin Plast Surg; 2009 Jul;36(3):379-97
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  • The eyelids are critical in the protection of the conjunctiva and sclera of the globe and, in turn, the preservation of vision.

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  • (PMID = 19505609.001).
  • [ISSN] 1558-0504
  • [Journal-full-title] Clinics in plastic surgery
  • [ISO-abbreviation] Clin Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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23. Lee JI, Kim MJ, Kim IH, Kim YB, Kim MC: Surgical correction of corneal dermoid in a dog. J Vet Sci; 2005 Dec;6(4):369-70
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  • On ophthalmic examination, left eye revealed hyperemia in conjunctiva of the temporal canthus due to choristoma with hair.
  • At surgery, the choristoma invaded by stromal layer of the cornea, and extended to limbus and conjunctiva.

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  • (PMID = 16294006.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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24. Yurdakök K, Güner SN, Yalçin SS: Validity of using pallor to detect children with mild anemia. Pediatr Int; 2008 Apr;50(2):232-4
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  • METHODS: Healthy children aged 6-24 months (n = 141) admitted to well baby clinic were assessed for the presence of pallor at three anatomic sites (palm, conjunctiva, buccal mucosa) on admission by two blinded observers (Integrated Management of Childhood Illness [IMCI] certificate pediatrician and a pediatric resident).
  • The interobserver agreement was highest for buccal and conjunctival pallor (kappa = 0.64 and 0.63, respectively), and lowest for palmar pallor (kappa = 0.49).
  • [MeSH-major] Anemia, Iron-Deficiency / complications. Anemia, Iron-Deficiency / diagnosis. Pallor / etiology

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  • (PMID = 18353066.001).
  • [ISSN] 1442-200X
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Australia
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25. Yalçin SS, Unal S, Gümrük F, Yurdakök K: The validity of pallor as a clinical sign of anemia in cases with beta-thalassemia. Turk J Pediatr; 2007 Oct-Dec;49(4):408-12
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  • Patients with beta-thalassemia A aged 2 to 32 years who were admitted to the Hematology Unit, Department of Pediatrics, Ihsan Doğramaci Children's Hospital, Ankara, Turkey were assessed for the presence of pallor in three anatomic sites (palm, conjunctiva, buccal mucosa) by a trained pediatrician.
  • The sensitivities of palmar, buccal and conjunctival pallor for identifying thalassemic children with anemia were 93.2, 80.7 and 90.9%, respectively.
  • Cases with Hb values less than 11 g/dl could be easily detected by conjunctival pallor, independent of serum ferritin levels.
  • Conjunctival pallor was more useful than buccal and palmar pallor in cases with high ferritin levels.
  • [MeSH-major] Anemia / diagnosis. Pallor / etiology. Physical Examination / methods. beta-Thalassemia / blood
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Conjunctiva / pathology. Female. Ferritins / blood. Hand / pathology. Hemoglobins / analysis. Humans. Male. Mouth Mucosa / pathology. Sensitivity and Specificity. Turkey


26. Gao Q, Mou S, Ge J, To CH, Hui Y, Liu A, Wang Z, Long C, Tan J: A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve. Eye (Lond); 2008 Mar;22(3):461-8
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  • Physiological balanced solution (PBS) was then injected into the capsule and inflated to support retina and control intraocular pressure (IOP) through the tube-valve system subsequently fixed under the conjunctiva.

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  • (PMID = 17525767.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Silicone Elastomers
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27. Cham G, Pan JC, Lim F, Earnest A, Gopalakrishnakone P: Effects of topical heparin, antivenom, tetracycline and dexamethasone treatment in corneal injury resulting from the venom of the black spitting cobra (Naja sumatrana), in a rabbit model. Clin Toxicol (Phila); 2006;44(3):287-92
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  • Pooled venom was frozen at -30 degrees C. 0.05 mL of 20 times dilute venom was introduced into the conjunctiva, in groups of three rabbits randomly.

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  • (PMID = 16749547.001).
  • [ISSN] 1556-3650
  • [Journal-full-title] Clinical toxicology (Philadelphia, Pa.)
  • [ISO-abbreviation] Clin Toxicol (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antivenins; 0 / Cobra Venoms; 0 / Ointments; 7S5I7G3JQL / Dexamethasone; 9005-49-6 / Heparin; F8VB5M810T / Tetracycline
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28. Ishige I, Eishi Y, Takemura T, Kobayashi I, Nakata K, Tanaka I, Nagaoka S, Iwai K, Watanabe K, Takizawa T, Koike M: Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis; 2005 Mar;22(1):33-42
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  • DNA of 45 isolates of P. acnes from these patients, 67 isolates from normal skin, conjunctiva, and intestine, and 39 isolates from sarcoid lymph nodes were compared by random amplified polymorphic DNA analysis.

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  • (PMID = 15881278.001).
  • [ISSN] 1124-0490
  • [Journal-full-title] Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
  • [ISO-abbreviation] Sarcoidosis Vasc Diffuse Lung Dis
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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29. Mondal SK, Banerjee A, Ghosh A: Histopathological study of conjunctival lesions. J Indian Med Assoc; 2007 Apr;105(4):206, 208, 212
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  • [Title] Histopathological study of conjunctival lesions.
  • Lesions of conjunctiva comprise a varied spectrum of conditions.
  • A total of 50 patients, 34 males and 16 females, with lesions in conjunctiva were subjected to study.
  • The study was done to report the spectrum and frequency of different lesions of conjunctiva in a tertiary care eye hospital in India.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy. Conjunctival Diseases / pathology. Eosine Yellowish-(YS). Female. Hematoxylin. Humans. Male. Middle Aged. Singapore

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  • (PMID = 17822190.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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30. Napora KJ, Obuchowska I, Łyson T, Sieśkiewicz A, Bień M, Mariak Z, Mariak Z: [Modern neurosurgical techniques to remove intraorbital foreign bodies--report of two cases]. Klin Oczna; 2009;111(7-9):240-5
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  • During the primary ophthalmological intervention--orbitotomy accessed through the conjunctiva of the fornix of the upper eyelid and the second cut through the wound in the eyelid--the foreign body was not removed.
  • During the primary ophthalmological operation--orbitotomy accessed through the conjunctiva of the fornix of the lower eyelid--the foreign body was not removed.
  • The patient was moved to the Department of Neurosurgery, where the surgeon unsuccesfuly attempted to remove the foreign body through the wound in the conjunctiva of the fornix of the lower eyelid with the aid of neuronavigation.

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  • (PMID = 19899582.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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31. Hashimoto T, Dainichi T, Ohyama B, Hamada T, Ishii N, Sato N, Tanigawa O, Nakayama J, Amano S, Nishiyama T, Karashima T, Nakama T, Yasumoto S: A case of antilaminin 332 mucous membrane pemphigoid showing a blister on the bulbar conjunctiva and a unique epitope on the alpha3 subunit. Br J Dermatol; 2010 Apr;162(4):898-9
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  • [Title] A case of antilaminin 332 mucous membrane pemphigoid showing a blister on the bulbar conjunctiva and a unique epitope on the alpha3 subunit.
  • [MeSH-major] Cell Adhesion Molecules / immunology. Conjunctiva / immunology. Pemphigoid, Benign Mucous Membrane / immunology

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  • (PMID = 20199543.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Anti-Inflammatory Agents; 0 / Cell Adhesion Molecules; 0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / kalinin; 8W5C518302 / Dapsone; 9PHQ9Y1OLM / Prednisolone
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32. Kalpravidh M, Tuntivanich P, Vongsakul S, Sirivaidyapong S: Canine amniotic membrane transplantation for corneal reconstruction after the excision of dermoids in dogs. Vet Res Commun; 2009 Dec;33(8):1003-12
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  • Slight pigmentation of the bulbar conjunctiva at the limbus was observed in 1 dog that had pre-existing pigmentary keratitis.

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  • (PMID = 19760128.001).
  • [ISSN] 1573-7446
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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33. Messmer EM, Bulgen M, Kampik A: Hyperosmolarity of the tear film in dry eye syndrome. Dev Ophthalmol; 2010;45:129-38
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  • Dry eye diagnosis was established when > or =3 of the following criteria were fulfilled:(1) Ocular Surface Disease Index > 15;.
  • (3) staining of the conjunctiva in the typical interpalpebral area;.
  • Technical problems with the Tearlab, reflex tearing, or the difficulty in establishing a dry eye diagnosis with the recommended tests may account for these results.
  • [MeSH-major] Diagnostic Techniques, Ophthalmological. Dry Eye Syndromes / diagnosis. Tears / chemistry

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20502033.001).
  • [ISSN] 0250-3751
  • [Journal-full-title] Developments in ophthalmology
  • [ISO-abbreviation] Dev Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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34. Tsurumaru N, Arai M, Teruya K, Sueda J, Yamakawa R: Seprafilm as a new antifibrotic agent following trabeculectomy in rabbit eyes. Jpn J Ophthalmol; 2009 Mar;53(2):164-70
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  • PURPOSE: To investigate the efficacy of Seprafilm (Genzyme, Framingham, MA, USA) in preventing postoperative adhesion between the conjunctiva and sclera after glaucoma filtering surgery.
  • RESULTS: The mean adhesive force between the conjunctiva and sclera in the Seprafilm group (125.6 +/- 94.5 mmHg) was lower than that of the non-Seprafilm group (263.3 +/- 79.3 mmHg) (P = 0.0041, unpaired t test).
  • CONCLUSIONS: Seprafilm can reduce postoperative conjunctiva-sclera adhesion and may be a desirable antifibrotic agent for trabeculectomy in the early stages of wound repair.
  • [MeSH-major] Conjunctival Diseases / prevention & control. Hyaluronic Acid / therapeutic use. Membranes, Artificial. Postoperative Complications. Scleral Diseases / prevention & control. Trabeculectomy

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  • (PMID = 19333702.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Membranes, Artificial; 0 / Seprafilm; 9004-61-9 / Hyaluronic Acid
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35. Haicl P, Janková H: [Prevalance of conjunctival concretions]. Cesk Slov Oftalmol; 2005 Jul;61(4):260-4
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  • [Title] [Prevalance of conjunctival concretions].
  • AIM: To establish prevalence of conjunctival concretions in a random cohort of patients visiting the general outpatients' department of the Department of Ophthalmology of the Faculty Hospital and 1st Medical faculty, Charles University in Prague, Czech Republic.
  • The complete eye examination, including detailed check-up of tarsal conjunctiva and conjunctiva of the fornices at the slit lamp was performed.
  • The presence of conjunctival concretions, frequency of the foreign body sensation in patients with concretions, localization of the concretions and their structure, dependence of the concretions' presentation on the patient's age, the dysfunction of the Meibomian glands, and chronic meibomitis were established.
  • RESULTS: The presence of the conjunctival concretions was found in 198 patients (39.6%), symptomatic were 6% of patients with deposits only.
  • In 30.3% of patients with conjunctival concretions, the dysfunction of Meibomian glands, or chronic meibomitis were detected.
  • SUMMARY: Frequent presence of conjunctival deposits in random cohort of patients was established, and occurrence in younger groups of patients was noticed.
  • [MeSH-major] Calculi / diagnosis. Conjunctival Diseases / diagnosis

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  • (PMID = 16164094.001).
  • [ISSN] 1211-9059
  • [Journal-full-title] Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
  • [ISO-abbreviation] Cesk Slov Oftalmol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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36. Tavolato M, Babighian S, Galan A: Spontaneous extrusion of a stainless steel glaucoma drainage implant (Ex-PRESS). Eur J Ophthalmol; 2006 Sep-Oct;16(5):753-5
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  • METHODS: An Ex-PRESS was implanted under the conjunctiva in a 76-year-old man with primary open-angle glaucoma.
  • Implanting the device under a scleral flap should be considered to avoid adverse events such as extrusion or conjunctival erosion.

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  • (PMID = 17061230.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Ayyala RS, Duarte JL, Sahiner N: Glaucoma drainage devices: state of the art. Expert Rev Med Devices; 2006 Jul;3(4):509-21
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  • Glaucoma drainage devices (GDDs) create an alternate aqueous pathway by channeling aqueous from the anterior chamber through a long tube to an equatorial plate, inserted under the conjunctiva, which promotes bleb formation.

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  • (PMID = 16866647.001).
  • [ISSN] 1743-4440
  • [Journal-full-title] Expert review of medical devices
  • [ISO-abbreviation] Expert Rev Med Devices
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biocompatible Materials
  • [Number-of-references] 127
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38. Coman OA, Rotar C, Stoleru S, Ghiţă-Cristescu I, Păunescu H, Fulga I: Influencing vascular reactivity in vivo by histaminergic agonists and antagonists. Rom J Morphol Embryol; 2007;48(4):403-6
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  • The aim of the present study is to analyze the differences in reactivity between the iris and conjunctiva vessels after the topical administration of histamine and histamine receptor blockers respectively.
  • The results show differences in reactivity between iris and conjunctiva vascular territories.

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  • (PMID = 18060191.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Histamine Agonists; 0 / Histamine Antagonists; 820484N8I3 / Histamine; 884KT10YB7 / Ranitidine; FF28EJQ494 / Promethazine; J76UF062FS / Pancuronium
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39. Coats DK: Cul-de-sac incision for strabismus surgery in older patients. Binocul Vis Strabismus Q; 2009;24(4):233-5
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  • [Title] Cul-de-sac incision for strabismus surgery in older patients.
  • INTRODUCTION: A limbal surgical approach for strabismus surgery is often recommended for older patients, in the belief that the conjunctiva of older patients is too thin and prone to tear during surgery performed through a cul-de-sac incision.
  • The purpose of this study was to evaluate the use of the cul-de-sac approach in patients more than 40 years of age.
  • METHODS: This is a retrospective analysis of consecutive patients more than 40 years of age who underwent strabismus surgery using a modified cul-de-sac approach to reduce manipulation of the conjunctiva during surgery.
  • RESULTS: A total of 32 cul-de-sac incisions were used to operate on 37 muscles in 19 consecutive patients more than 40 years old.
  • Tears resulting in extension of the conjunctival incision occurred in several patients, but no other complications were encountered.
  • CONCLUSION: Strabismus surgery can be performed through a cul-de-sac incision in older patients.
  • Slight modifications of the surgical technique to prevent excessive manipulation of the incision and to reduce the risk of tearing the conjunctiva are helpful.
  • The cul-de-sac approach offers some important potential advantages to older patients undergoing strabismus surgery.

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  • (PMID = 20001952.001).
  • [ISSN] 1088-6281
  • [Journal-full-title] Binocular vision & strabismus quarterly
  • [ISO-abbreviation] Binocul Vis Strabismus Q
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Komáromy AM, Varner SE, de Juan E, Acland GM, Aguirre GD: Application of a new subretinal injection device in the dog. Cell Transplant; 2006;15(6):511-9
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  • After removing the CSID, the conjunctiva over the sclerotomy site had to be closed.
  • In a second group of 28 dogs [16 normals, 10 RPE65 mutants, and 2 with progressive rod cone degeneration (prcd)], the 25-gauge needle of the RetinaJect was used to penetrate the conjunctiva and the sclera.
  • No closure of the conjunctiva was required.
  • The main advantage of the RetinaJect was that no surgical dissection was required; this led to a shorter procedure time and milder postoperative conjunctival swelling.

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  • (PMID = 17121162.001).
  • [ISSN] 0963-6897
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY06855; United States / NEI NIH HHS / EY / EY13132; United States / NEI NIH HHS / EY / EY13729; United States / NEI NIH HHS / EY / EY15398
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Vlasov SK: [Changes in the organ of vision in pathological tortuosity and atherosclerotic stenosis of the carotid arteries]. Vestn Oftalmol; 2010 Sep-Oct;126(5):58-62
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  • There are nonspecific and specific signs of circulatory disorders in the anterior ocular segment - bulbar conjunctiva.

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  • (PMID = 21328897.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
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42. Pisella PJ: [Pathology of the ocular surface]. Rev Prat; 2006 Jun 15;56(11):1226-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Pathologie de la surface oculaire.
  • The ocular surface is a new concept including the cornea, the conjunctiva, the lids and the lachrymal tear film in a new approach as an anatomic, physiologic and physiopathologic entity.
  • [MeSH-major] Conjunctivitis / diagnosis. Dry Eye Syndromes / diagnosis

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  • (PMID = 16903523.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 8
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43. Santos NC, de Sousa LB, Trevisani VF, Rigueiro MP, de Freitas D: [Bilateral epibulbar rheumatoid nodulosis: case report]. Arq Bras Oftalmol; 2006 May-Jun;69(3):439-42
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  • [Transliterated title] Nodulose reumatóide epibulbar bilateral: relato de caso.
  • A 64-year-old woman with a diagnosis of rheumatoid arthritis developed painless bilateral episcleral rheumatoid nodules without any flare-up of her associated disease.
  • Biopsy of the lesions disclosed a lymphocytic and plasmacytic infiltration within the conjunctiva, overlying palisading granulomas with multinucleated giant cells, and central necrobiotic degeneration of the collagen of the episclera and superficial sclera.
  • [MeSH-major] Rheumatoid Nodule / diagnosis. Scleritis / diagnosis

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  • (PMID = 16936975.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 8N3DW7272P / Cyclophosphamide
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44. Bräuer L, Kindler C, Jäger K, Sel S, Nölle B, Pleyer U, Ochs M, Paulsen FP: Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system. Invest Ophthalmol Vis Sci; 2007 Sep;48(9):3945-53
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  • METHODS: Expression of mRNA for SP-A and SP-D was analyzed by RT-PCR in healthy lacrimal gland, conjunctiva, cornea, and nasolacrimal ducts as well as in a spontaneously immortalized conjunctival epithelial cell line (HCjE; IOBA-NHC) and a SV40-transfected cornea epithelial cell line (HCE).
  • RESULTS: The presence of SP-A and SP-D on mRNA and protein levels was evidenced in healthy lacrimal gland, conjunctiva, cornea, and nasolacrimal duct samples.
  • Immunohistochemistry revealed the production of both peptides by acinar epithelial cells of the lacrimal gland and epithelial cells of the conjunctiva and nasolacrimal ducts, whereas goblet cells revealed no reactivity.
  • [MeSH-minor] Aged. Aged, 80 and over. Blotting, Western. Cell Line. Conjunctiva / metabolism. Cornea / metabolism. Female. Humans. Immunoblotting. Immunoenzyme Techniques. Keratitis, Herpetic / metabolism. Keratoconus / metabolism. Male. Middle Aged. Nasolacrimal Duct / metabolism. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17724171.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pulmonary Surfactant-Associated Protein A; 0 / Pulmonary Surfactant-Associated Protein D; 0 / RNA, Messenger
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45. Lo Russo L, Fierro G, Guiglia R, Compilato D, Testa NF, Lo Muzio L, Campisi G: Epidemiology of desquamative gingivitis: evaluation of 125 patients and review of the literature. Int J Dermatol; 2009 Oct;48(10):1049-52
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  • There was extra-oral involvement of skin in 14% of patients, conjunctiva in 7%, genital mucosa in 26%, and internal organs in 3%.

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  • (PMID = 19775398.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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46. Below H, Behrens-Baumann W, Bernhardt C, Völzke H, Kramer A, Rudolph P: Systemic iodine absorption after preoperative antisepsis using povidone-iodine in cataract surgery-- an open controlled study. Dermatology; 2006;212 Suppl 1:41-6
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  • After preoperative conjunctival and periorbital antisepsis with povidone-iodine (PVP-I), the systemic absorption of iodine after cataract surgery was measured to evaluate the risk of thyroid side effects.
  • Five different combinations of PVP-I alone or in combination with PVP-I-free antiseptics were applied to the conjunctiva and periorbital skin.
  • Because the iodine absorption is only slight and of doubtful clinical relevance, presurgical conjunctival antisepsis can be achieved with 1.25% PVP-I; so far clinically manifest anamnestic thyroid disorders are excluded.

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  • (PMID = 16490974.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 25655-41-8 / Povidone-Iodine; 9679TC07X4 / Iodine
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47. Cagigrigoriu A, Boero E, Carenini AB, Rolle T, Cappia S, Bacillo E, Papotti M, Gregori D, Brovarone FV, Grignolo FM: Do antiglaucomatous prostaglandins induce melanogenesis in human conjunctiva?: an impression cytology pilot study. J Glaucoma; 2010 Jan;19(1):44-50
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  • [Title] Do antiglaucomatous prostaglandins induce melanogenesis in human conjunctiva?: an impression cytology pilot study.
  • PURPOSE: To determine the effect of antiglaucomatous prostaglandin analogs on conjunctival melanogenesis.
  • Skin complexion, eye color, conjunctival pigmentation, lacrimal tests, and corneal fluorescein staining were evaluated.
  • Immunoreactivity for Tyrosinase was assayed on conjunctival imprints.
  • RESULTS: Twenty percent of patients treated with prostaglandins and 10% of the control subjects clinically manifested conjunctival pigmentation (P=0.279).
  • Only 4% (8/198) of the conjunctival specimens were positive to Tyrosinase immunostaining, with no statistically significant difference among the groups (P=0.449).
  • CONCLUSIONS: According to our preliminary results, prostaglandin antiglaucomatous analogs do not significantly enhance pigmentation in the superficial layers of the conjunctiva.
  • The existence of the Tyrosinase enzyme in the superficial layers of the conjunctiva suggests that basal melanocytes may transfer their melanogenic apparatus to superficial epithelial cells.
  • [MeSH-major] Antihypertensive Agents / administration & dosage. Conjunctiva / drug effects. Melanins / metabolism. Prostaglandins F, Synthetic / administration & dosage

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  • (PMID = 20075674.001).
  • [ISSN] 1536-481X
  • [Journal-full-title] Journal of glaucoma
  • [ISO-abbreviation] J. Glaucoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Antihypertensive Agents; 0 / Melanins; 0 / Ophthalmic Solutions; 0 / Prostaglandins F, Synthetic; EC 1.14.18.1 / Monophenol Monooxygenase
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48. Uusitalo H, Chen E, Pfeiffer N, Brignole-Baudouin F, Kaarniranta K, Leino M, Puska P, Palmgren E, Hamacher T, Hofmann G, Petzold G, Richter U, Riedel T, Winter M, Ropo A: Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol; 2010 May;88(3):329-36
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  • The patients were queried for ocular symptoms, and ocular signs were assessed by using tear break-up time, Schirmer's test, fluorescein staining and evaluation of conjunctival hyperaemia and blepharitis.
  • In addition, HLA-DR and MUC5AC in conjunctival impression cytology specimens were analyzed, and a drop discomfort/quality of life (QoL) questionnaire was employed.
  • The number of the patients with abnormal fluorescein staining of cornea (81.6%) and conjunctiva (84.2%), blepharitis (60.1%), conjunctival hyperaemia (84.2%) and abnormal Schirmer's test (71.5%) was also reduced significantly to 40.6%, 43.2%, 40.6%, 60.0% and 59.4% correspondingly.
  • A reduction in the number of patients with abnormal conjunctival cells based on HLA-DR and MUC5AC was also detected.
  • [MeSH-minor] Administration, Topical. Adult. Aged. Aged, 80 and over. Blepharitis / chemically induced. Blepharitis / metabolism. Blepharitis / prevention & control. Conjunctival Diseases / chemically induced. Conjunctival Diseases / metabolism. Conjunctival Diseases / prevention & control. Female. Gonioscopy. HLA-DR Antigens / metabolism. Humans. Hyperemia / chemically induced. Hyperemia / metabolism. Hyperemia / prevention & control. Male. Middle Aged. Mucin 5AC / metabolism. Ocular Hypertension / drug therapy. Ophthalmoscopy. Patient Satisfaction. Prostaglandins F, Synthetic / administration & dosage. Prostaglandins F, Synthetic / adverse effects. Quality of Life. Surveys and Questionnaires. Tonometry, Ocular

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  • (PMID = 20546237.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Benzalkonium Compounds; 0 / HLA-DR Antigens; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Preservatives, Pharmaceutical; 0 / Prostaglandins F; 0 / Prostaglandins F, Synthetic; 1O6WQ6T7G3 / tafluprost; 6Z5B6HVF6O / latanoprost
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49. Korb DR, Herman JP, Finnemore VM, Exford JM, Blackie CA: An evaluation of the efficacy of fluorescein, rose bengal, lissamine green, and a new dye mixture for ocular surface staining. Eye Contact Lens; 2008 Jan;34(1):61-4
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  • PURPOSE: Sodium fluorescein is considered the premier dye for corneal staining and, similarly, rose bengal (RB) for conjunctival staining.
  • The purposes of this study were to review the clinical staining characteristics of fluorescein, rose bengal, and lissamine green in controlled dose and concentration and determine whether optimal staining of the cornea and bulbar conjunctiva are possible by using dye mixtures.
  • Fourteen subjects with a diagnosis of dry eye were tested for staining with various combinations of the dyes.
  • RESULTS: A mixture of 2% fluorescein and 1% rose bengal was the most efficacious staining mixture for the cornea and conjunctiva, but moderate to marked discomfort was reported.
  • The mixture of 2% fluorescein and 1% lissamine green did not result in discomfort and provided optimal corneal and conjunctival staining with only slightly less efficacy than 2% fluorescein and 1% rose bengal; 2% and 3% lissamine green produced burning and discomfort.
  • The preferred mixture for simultaneous and efficacious staining of the cornea and conjunctiva without an adverse sensation was 2% fluorescein and 1% lissamine green.
  • CONCLUSIONS: A mixture of 2% fluorescein and 1% lissamine green offers excellent simultaneous corneal and bulbar conjunctival staining and could replace the use of individual dyes for ocular staining and contact lens practice.
  • [MeSH-major] Conjunctiva / pathology. Cornea / pathology. Dry Eye Syndromes / diagnosis. Fluorescein. Lissamine Green Dyes. Rose Bengal. Staining and Labeling / methods

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  • (PMID = 18180687.001).
  • [ISSN] 1542-2321
  • [Journal-full-title] Eye & contact lens
  • [ISO-abbreviation] Eye Contact Lens
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Drug Combinations; 0 / Lissamine Green Dyes; 0 / Ophthalmic Solutions; 1ZPG1ELY14 / Rose Bengal; TPY09G7XIR / Fluorescein
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50. Demir U, Demir T, Ilhan N: The protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation. Ophthalmologica; 2005 Jan-Feb;219(1):49-53
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  • [Title] The protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation.
  • PURPOSE: The purpose of this study was to determine the protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation.
  • The rabbits were exposed to 2 J/cm(2)/h of ultraviolet A radiation (UVA) in the range of 320-405 nm for 12 h per day within 90 days.
  • Conjunctival and corneal free malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) levels were compared among the groups.
  • RESULTS: Conjunctival free MDA levels were lower in the alpha-lipoic acid group compared with the UVA and PUVA groups (p < 0.05, p < 0.001, respectively).
  • Both conjunctival SOD levels (p < 0.05, p < 0.01, respectively) and conjunctival GSH-PX levels (p < 0.01, p < 0.001, respectively) were higher in the alpha-lipoic acid group compared with other groups.
  • [MeSH-major] Antioxidants / therapeutic use. Conjunctiva / radiation effects. Conjunctival Diseases / prevention & control. Cornea / radiation effects. Corneal Diseases / prevention & control. Radiation Injuries, Experimental / prevention & control. Thioctic Acid / therapeutic use

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15627828.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 4Y8F71G49Q / Malondialdehyde; 73Y7P0K73Y / Thioctic Acid; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; U4VJ29L7BQ / Methoxsalen
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51. Pakravan M, Klesert TR, Akpek EK: Isolated lichen planus of the conjunctiva. Br J Ophthalmol; 2006 Oct;90(10):1325-6
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  • [Title] Isolated lichen planus of the conjunctiva.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Lichen Planus / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Dry Eye Syndromes / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 16980648.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1857434
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52. Aihara M, Saito Y, Higashide T, Okubo S, Sasaki T, Sugiyama K: Conjunctival vasculature patterns influencing the filtering bleb shape following trabeculectomy with limbal-based conjunctival flaps. Jpn J Ophthalmol; 2009 Jul;53(4):374-9
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  • [Title] Conjunctival vasculature patterns influencing the filtering bleb shape following trabeculectomy with limbal-based conjunctival flaps.
  • PURPOSE: To investigate the correlation between conjunctival vasculature factors and two types of functional bleb shape, cystic and diffuse, formed after trabeculectomy with limbal-based conjunctival flaps.
  • For each bleb type, the presence of neovascularized vessels in the dissected area (NVc) or the nondissected area (NVi), an avascular area (AVA), or a posterior tarsal artery (PTA) feeding the conjunctiva was analyzed.
  • CONCLUSIONS: Avoidance of damage to the PTA during conjunctival dissection might facilitate the formation of a diffuse filtration bleb.
  • The conjunctival vasculature should be considered to avoid cystic avascular bleb formation in trabeculectomy with limbal-based flaps.
  • [MeSH-major] Conjunctiva / blood supply. Glaucoma / surgery. Neovascularization, Physiologic. Surgical Flaps / blood supply. Surgical Flaps / pathology. Surgically-Created Structures. Trabeculectomy

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  • (PMID = 19763754.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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53. Hong S, Kim T, Chung SH, Kim EK, Seo KY: Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren's syndrome. J Ocul Pharmacol Ther; 2007 Feb;23(1):78-82
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  • Additionally, impression cytology of the bulbar conjunctiva was performed.

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  • (PMID = 17341155.001).
  • [ISSN] 1080-7683
  • [Journal-full-title] Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • [ISO-abbreviation] J Ocul Pharmacol Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Ophthalmic Solutions; 0 / Preservatives, Pharmaceutical; X4W7ZR7023 / Methylprednisolone
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54. Qi F, Xie LX: [Updates on tissue engineering of the eye]. Zhonghua Yan Ke Za Zhi; 2009 Mar;45(3):285-8
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  • Tissue engineering conjunctiva and corneal epithelia have been clinically well applied in the reconstruction of the ocular surface; immortalizing corneal endothelia may be the key problem in creating tissue engineering cornea; and the future of tissue engineering retina may be not as good as that of artificial retina.
  • [MeSH-minor] Conjunctiva. Humans. Retina

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  • (PMID = 19575931.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
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55. Aspiotis M, Gorezis S, Asproudis I, Tsanou E, Papadiotis E, Kamina S, Agnantis NJ, Bai M: Primary mantle cell lymphoma of the conjunctiva: a case report. Virchows Arch; 2006 Oct;449(4):472-5
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  • [Title] Primary mantle cell lymphoma of the conjunctiva: a case report.
  • Primary non-Hodgkin's lymphomas of the conjunctiva are uncommon.
  • In this study, we report an extremely rare case of conjunctival mantle cell lymphoma in a 78-year-old man, presenting as a unilateral epibulbar mass.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / pathology. Lymphoma, Mantle-Cell / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Humans. Immunohistochemistry. Male

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  • (PMID = 16969632.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Bivolaru I, Selaru D, Serghiescu I: [Ocular melanocytosis and delayed psycho-intellectual development--other association?]. Oftalmologia; 2009;53(3):101-4
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  • The conjunctival epithelium is not affected, as opposed to conjunctival melanosis.
  • The pigmentation is grayish-blue and its consistency with the underlying tissues as the conjunctiva moves (deep pigmentation) is an essential diagnostic clue.
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Iris / pathology. Male. Sclera / pathology. Syndrome

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  • (PMID = 19899554.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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57. Hinkle DM, Karcioglu ZA: Conjunctival biopsy of anophthalmic socket in sarcoidosis. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):163-4
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  • [Title] Conjunctival biopsy of anophthalmic socket in sarcoidosis.
  • A case of sarcoidosis was diagnosed by a random conjunctival biopsy from an anophthalmic socket.
  • Biopsy of subconjunctival nodules in the left eye failed to demonstrate granulomatous inflammation; however, a random conjunctival biopsy from the normal-appearing anophthalmic socket conjunctiva revealed noncaseating granulomas.
  • Conjunctival biopsy is a safe, cost-effective means of diagnosis in sarcoidosis suspects.
  • To our knowledge, this is the first reported case of sarcoidosis confirmed with random conjunctival biopsy from an anophthalmic socket.
  • [MeSH-major] Anophthalmos / pathology. Conjunctiva / pathology. Conjunctival Diseases / diagnosis. Eye Enucleation. Sarcoidosis / diagnosis
  • [MeSH-minor] Adult. Biopsy. Eye Injuries, Penetrating / surgery. Female. Humans. Sarcoidosis, Pulmonary / diagnosis

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  • (PMID = 15778678.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Rao NG, Mahapatra SK, Pattnayak S, Pattnaik K: Intravitreal live adult Brugian filariasis. Indian J Ophthalmol; 2008 Jan-Feb;56(1):76-8
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  • It involves the eyelids, conjunctiva, cornea, anterior chamber and uvea.

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  • [Cites] Ann Trop Med Parasitol. 2000 Jan;94(1):83-6 [10723527.001]
  • [Cites] Clin Microbiol Rev. 1998 Apr;11(2):366-81 [9564568.001]
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  • (PMID = 18158414.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2636063
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59. Coman OA, Savu OR, Ghiţă I, Păunescu H, Coman L, Fulga I: [Effects of serotonin on reactivity of ocular vasculature]. Oftalmologia; 2007;51(4):126-33
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  • The aim of this study was to analyze the differences in reactivity between the vessels (arteries and veins) of the iris and conjunctiva.
  • RESULTS: There were obtained differences in reactivity between iris and conjunctival vessels and between iris arteries and veins for the different concentrations of tested serotonin solutions.
  • CONCLUSIONS: Iris and conjunctival vessels contain serotonin receptors with different types and densities, whose activation produced vasoconstriction in both territories, but with different evolution and intensity.
  • The different vascular response might be a protective mechanism against dissemination of conjunctival infections.
  • [MeSH-major] Arteries / drug effects. Conjunctiva / blood supply. Conjunctiva / drug effects. Iris / blood supply. Iris / drug effects. Serotonin / metabolism. Serotonin Agents / pharmacology. Veins / drug effects

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  • (PMID = 18543689.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Receptors, Serotonin; 0 / Serotonin Agents; 0 / Vasodilator Agents; 333DO1RDJY / Serotonin; OL961R6O2C / Felodipine
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60. Bongiorno MR, Lodato G, Affronti A, Aragona F, Aricò M: Amelanotic conjunctival melanoma. Cutis; 2006 Jun;77(6):377-81
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  • [Title] Amelanotic conjunctival melanoma.
  • Conjunctival melanoma is a rare condition of the eye pigment predominantly affecting white adults.
  • We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus.
  • The de novo amelanotic malignant melanoma of the conjunctiva we describe is an extremely uncommon tumor mainly affecting white adults.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • (PMID = 16838771.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Pflugfelder SC, Stern ME: Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol; 2007 Oct;7(5):450-3
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  • [Title] Future directions in therapeutic interventions for conjunctival inflammatory disorders.
  • PURPOSE OF REVIEW: To review recent advances in pathogenesis and treatment of conjunctival inflammatory disorders.
  • RECENT FINDINGS: The conjunctiva becomes inflamed in a number of conditions, including allergy, atopy, dry eye, mucus membrane pemphigoid, Stevens-Johnson syndrome and surgical manipulation.
  • SUMMARY: Increased understanding of the key mediators of conjunctival inflammation coupled with improved drug delivery methods are leading to more effective therapy for conjunctival inflammatory disorders.
  • [MeSH-minor] Animals. Conjunctiva / immunology. Cytokines / immunology. Cytokines / metabolism. Humans

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  • (PMID = 17873588.001).
  • [ISSN] 1528-4050
  • [Journal-full-title] Current opinion in allergy and clinical immunology
  • [ISO-abbreviation] Curr Opin Allergy Clin Immunol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 26
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62. Auxenfans C, Builles N, Andre V, Lequeux C, Fievet A, Rose S, Braye FM, Fradette J, Janin-Manificat H, Nataf S, Burillon C, Damour O: [Porous matrix and primary-cell culture: a shared concept for skin and cornea tissue engineering]. Pathol Biol (Paris); 2009 Jun;57(4):290-8
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  • [Transliterated title] Matrice poreuse et culture de cellules primaires : un même concept pour la reconstruction cutanée et cornéenne.
  • The basal layer of the limbal epithelium is located in a transitional zone between the cornea and the conjunctiva and contains the stem cell population of the corneal epithelium called limbal-stem cells (LSC).

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  • (PMID = 18602223.001).
  • [ISSN] 1768-3114
  • [Journal-full-title] Pathologie-biologie
  • [ISO-abbreviation] Pathol. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Glycosaminoglycans; 9007-34-5 / Collagen; 9012-76-4 / Chitosan
  • [Number-of-references] 72
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63. Ueta M, Hamuro J, Ueda E, Katoh N, Yamamoto M, Takeda K, Akira S, Kinoshita S: Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. Invest Ophthalmol Vis Sci; 2008 Aug;49(8):3387-94
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  • The inflammatory infiltrates in the perioral skin consisted primarily of CD4(+) and CD8(+) cells; CD4(+) and CD45R/B220(+) cells were mainly detected in the conjunctiva.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Animals. CD4-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / immunology. Conjunctiva / pathology. Cytokines / genetics. Enzyme-Linked Immunosorbent Assay. Gene Expression. Genotype. Goblet Cells / pathology. Immunoglobulin E / blood. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Stevens-Johnson Syndrome / immunology. Stevens-Johnson Syndrome / pathology. Th2 Cells / immunology. Trans-Activators / physiology

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  • (PMID = 18441309.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cytokines; 0 / Nfkbiz protein, mouse; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / STAT6 Transcription Factor; 0 / Stat6 protein, mouse; 0 / Trans-Activators; 37341-29-0 / Immunoglobulin E
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64. Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22
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  • [Title] [Conjunctival tumors].
  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient.
  • Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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65. Persa C, Osmotherly K, Chao-Wei Chen K, Moon S, Lou MF: The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense. Exp Eye Res; 2006 Oct;83(4):817-23
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  • The goal of this study is to examine the distribution of CBS in the various regions of the eye, including conjunctiva, cornea, iris, lens, vitreous, retina and optic nerve using fresh eyes from both pigs (6 months) and humans (4-82 years).
  • We have found that pig eye showed the highest CBS protein presence in cornea, conjunctiva and iris, followed by retina and optic nerve.

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  • (PMID = 16769053.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY10595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 4.2.1.22 / Cystathionine beta-Synthase
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66. Koss MJ, Eder M, Blumenkranz MS, Klauss V, Ta CN, de Kaspar HM: [The effectiveness of the new fluoroquinolones against the normal bacterial flora of the conjunctiva]. Ophthalmologe; 2007 Jan;104(1):21-7
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  • [Title] [The effectiveness of the new fluoroquinolones against the normal bacterial flora of the conjunctiva].
  • [Transliterated title] Wirksamkeit neuer Fluorchinolone gegenüber der bakteriellen Normalflora der Bindehaut.
  • BACKGROUND: Our aim was to determine the antibiotic susceptibility of the preoperative conjunctival bacterial flora against 25 commonly used antibiotics, especially the new fluoroquinolones levofloxacin, gatifloxacin, and moxifloxacin.
  • PATIENTS AND METHODS: The Kirby-Bauer disk-diffusion technique was used to test for the in vitro antibiotic susceptibility of conjunctival bacterial strains isolated from 160 patients (median=74 years, mean=71 years) undergoing cataract surgery at the Department of Ophthalmology, Stanford University, CA, USA.
  • [MeSH-major] Conjunctiva / drug effects. Conjunctiva / microbiology. Conjunctivitis, Bacterial / drug therapy. Conjunctivitis, Bacterial / microbiology. Fluoroquinolones / administration & dosage. Staphylococcus / drug effects. Streptococcus / drug effects

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  • (PMID = 17160378.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Fluoroquinolones
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67. Veneziale RW, Bral CM, Sinha DP, Watkins RW, Cartwright ME, Rosenblum IY, Treinen KA, Kishnani NS, Nelson J, Chen Z, Faha B, Maneval D, Munger RJ, Cai XY, Cullen C, Arezzo JC: SCH 412499: biodistribution and safety of an adenovirus containing P21(WAF-1/CIP-1) following subconjunctival injection in Cynomolgus monkeys. Cutan Ocul Toxicol; 2007;26(2):83-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Findings included swollen, partially closed or shut eye(s) and transient congestion in the conjunctiva.
  • A mononuclear cell infiltrate was present in the conjunctiva, choroid and other ocular tissues, but completely or partially resolved over time.
  • [MeSH-minor] Anesthesia. Animals. Blood Pressure / physiology. Conjunctiva. Conjunctivitis / pathology. Electroretinography. Enzyme-Linked Immunosorbent Assay. Evoked Potentials, Visual / physiology. Eye / pathology. Female. Heart Rate / physiology. Injections. Macaca fascicularis. Male. Reverse Transcriptase Polymerase Chain Reaction. Tissue Distribution. Trabecular Meshwork. Wound Healing

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  • (PMID = 17612977.001).
  • [ISSN] 1556-9527
  • [Journal-full-title] Cutaneous and ocular toxicology
  • [ISO-abbreviation] Cutan Ocul Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21
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68. Beer F, Kuo CH, Morohoshi K, Goodliffe J, Munro P, Aye CC, Dawson M, Richardson RM, Jones LH, Ikeda Y, Nakamura T, Toda M, Flynn T, Ohbayashi M, Miyazaki D, Ono SJ: Role of beta-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies. Immunol Rev; 2007 Jun;217:96-104
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  • [Title] Role of beta-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies.
  • [MeSH-major] Chemokines, CC / metabolism. Conjunctiva / immunology. Hypersensitivity / immunology. Mast Cells / immunology. Receptors, IgE / immunology

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  • (PMID = 17498054.001).
  • [ISSN] 0105-2896
  • [Journal-full-title] Immunological reviews
  • [ISO-abbreviation] Immunol. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Chemokines, CC; 0 / Receptors, IgE
  • [Number-of-references] 18
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69. Gregory ME, Weir CR, Ramaesh K: Excision of granulation tissue and free conjunctival autograft in the management of necrotizing scleritis. Cornea; 2010 May;29(5):577-9
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  • [Title] Excision of granulation tissue and free conjunctival autograft in the management of necrotizing scleritis.
  • PURPOSE: To describe a novel use of conjunctival autograft in the management of surgically induced scleral necrosis that occurred after squint surgery.
  • Two weeks postoperatively, he developed conjunctival retraction and an area of scleral necrosis/melting with 80% thinning.
  • The surrounding conjunctiva was markedly inflamed with raised edges.
  • The conjunctiva surrounding the area of scleral melt was excised and the area covered by a conjunctival autograft resulting in complete healing of the scleral melt within 1 month of surgery.
  • CONCLUSION: The pathogenesis of surgically induced scleral necrosis not associated with autoimmune conditions may be the result of the products of inflammation and lytic enzymes released by the surrounding conjunctival tissue initiating the scleral melting process.
  • This type of surgically induced scleral necrosis may be successfully managed by excision of the surrounding inflamed conjunctiva, thus removing a potential source of collagenases, and covering the exposed sclera by a conjunctival transplant obviating the need for prolonged high-dose immunosuppression.
  • [MeSH-major] Conjunctiva / transplantation. Exotropia / surgery. Granulation Tissue / surgery. Postoperative Complications. Scleritis / surgery

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  • (PMID = 20335810.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Abedin A, Mohammed I, Hopkinson A, Dua HS: A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Invest Ophthalmol Vis Sci; 2008 Jan;49(1):28-33
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  • METHODS: Total RNA was obtained from impression cytology samples of the conjunctiva and cornea of normal patients and of those with bacterial, viral, acanthamoeba, or dry eye disease.
  • [MeSH-major] Acanthamoeba Keratitis / genetics. Anti-Infective Agents / metabolism. Antimicrobial Cationic Peptides / genetics. Conjunctiva / metabolism. Cornea / metabolism. Eye Infections / genetics. beta-Defensins / genetics

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  • (PMID = 18172071.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Antimicrobial Cationic Peptides; 0 / DEFB-109 peptide, human; 0 / RNA, Messenger; 0 / beta-Defensins
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71. Yamagami S, Ebihara N, Amano SY: Chemokine receptor gene expression in giant papillae of atopic keratoconjunctivitis. Mol Vis; 2005;11:192-200
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  • We evaluated chemokine receptor genes and their ligand expressions in upper tarsal conjunctival giant papillae of AKC with atopic dermatitis and/or asthma.
  • METHODS: CC, CXC, and CX3C chemokine receptor (R) gene expression levels in giant papillae of five clinically active AKC patients and in three age matched non-allergic control conjunctiva were measured with a multi-probe ribonuclease protection assay (RPA) system.
  • Ligand expression in cultured human conjunctival fibroblasts was examined by reverse transcription-polymerase chain reaction.
  • Cultured human conjunctival fibroblasts express stromal cell derived factor-1 (SDF-1/CXCL12) in vitro.
  • [MeSH-minor] Adolescent. Adult. Asthma / metabolism. Cell Culture Techniques. Child. Conjunctiva / metabolism. Dermatitis, Atopic / metabolism. Fibroblasts / metabolism. Fluorescent Antibody Technique, Indirect. Humans. Interleukin-13 / genetics. Interleukin-4 / genetics. Nuclease Protection Assays. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15788997.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-13; 0 / RNA, Messenger; 0 / Receptors, Chemokine; 207137-56-2 / Interleukin-4
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72. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Ozaki A, Ueno H: The immunization protocol determines whether endogenous interferon-gamma suppresses the infiltration of eosinophils into the conjunctiva. Immunol Lett; 2005 Sep 15;100(2):189-94
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  • [Title] The immunization protocol determines whether endogenous interferon-gamma suppresses the infiltration of eosinophils into the conjunctiva.
  • BACKGROUND: Studies with interferon-gamma knockout (GKO) mice showed that endogenous IFN-gamma suppresses the infiltration of inflammatory cells into the conjunctiva.
  • To examine whether this phenomenon is universally true, we induced conjunctival inflammation by four different immunization protocols.
  • RESULTS: Similar to a previous report, GKO mice showed significant eosinophilic infiltration into the conjunctiva after the footpad only injection of 50 microg RW.
  • On the contrary, either immunization of 100 microg RW in 2mg alum into only the left hind footpad or that of 25 microg RW in 2mg alum into both the left hind footpad and the tail base induced significant infiltration of eosinophils into the conjunctiva of GKO mice, compared to WT mice.

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  • (PMID = 15919119.001).
  • [ISSN] 0165-2478
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Allergens; 207137-56-2 / Interleukin-4; 37341-29-0 / Immunoglobulin E; 82115-62-6 / Interferon-gamma
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73. Waikagul J, Dekumyoy P, Yoonuan T, Praevanit R: Conjunctiva philophthalmosis: a case report in Thailand. Am J Trop Med Hyg; 2006 May;74(5):848-9
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  • [Title] Conjunctiva philophthalmosis: a case report in Thailand.
  • Examination conducted by an ophthalmologist revealed a small worm moving on the conjunctiva of the right eye.
  • [MeSH-major] Conjunctivitis / diagnosis. Eye Infections, Parasitic / diagnosis. Trematoda / isolation & purification. Trematode Infections / diagnosis
  • [MeSH-minor] Adult. Animals. Diagnosis, Differential. Female. Humans. Thailand

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  • (PMID = 16687691.001).
  • [ISSN] 0002-9637
  • [Journal-full-title] The American journal of tropical medicine and hygiene
  • [ISO-abbreviation] Am. J. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Popp MP, Liu L, Timmers A, Esson DW, Shiroma L, Meyers C, Berceli S, Tao M, Wistow G, Schultz GS, Sherwood MB: Development of a microarray chip for gene expression in rabbit ocular research. Mol Vis; 2007;13:164-73
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  • METHODS: Messenger RNA was isolated from anterior segment tissues (cornea, conjunctiva, and iris) and posterior segment tissues (lens, retina, and sclera) of rabbit eyes and used to create two independent cDNA libraries through the NEIBank project.
  • After 14 days, tissue was harvested from the conjunctiva and Tenon's capsule of both the surgically treated and untreated control eyes.

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  • (PMID = 17293780.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2536532
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75. Kiratli H, Kocabeyoğlu S, Bilgiç S: Severe pseudo-preseptal cellulitis following sub-Tenon's carboplatin injection for intraocular retinoblastoma. J AAPOS; 2007 Aug;11(4):404-5
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  • Sub-Tenon or subconjunctival administration of carboplatin is used to consolidate tumor regression by achieving high intraocular concentrations, without incurring systemic toxicity, in selected patients with intraocular retinoblastoma.
  • The development of this complication after injecting through the inferior conjunctiva and unexpectedly severe signs are the unusual features of these patients.
  • We did not encounter this complication after injections through the superior conjunctiva in 22 other patients using the same technique and identical drug dosage.

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  • (PMID = 17306997.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin
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76. Aghamohammadi A, Imai K, Moazzami K, Abolhassani H, Tabatabaeiyan M, Parvaneh N, Nasiri Kalmarzi R, Nakagawa N, Oshima K, Ohara O, Nonoyama S, Rezaei N: Ataxia-telangiectasia in a patient presenting with hyper-immunoglobulin M syndrome. J Investig Allergol Clin Immunol; 2010;20(5):442-5
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  • However, at the age of 4 years, a neurological examination revealed gait disturbance and telangiectatic lesions on the conjunctiva; therefore, a diagnosis of AT was suggested.
  • [MeSH-major] Ataxia Telangiectasia / diagnosis. Cell Cycle Proteins / genetics. DNA-Binding Proteins / genetics. Hyper-IgM Immunodeficiency Syndrome / diagnosis. Mutation / genetics. Protein-Serine-Threonine Kinases / genetics. Respiratory Tract Infections / diagnosis. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Ataxia Telangiectasia Mutated Proteins. Child. Child, Preschool. Conjunctiva / pathology. Fatal Outcome. Female. Gait Disorders, Neurologic. Humans. Immunoglobulin M / biosynthesis. Immunoglobulin M / genetics. Immunoglobulin M / immunology. Immunosuppression. Prognosis. Recurrence. Respiratory Insufficiency

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  • (PMID = 20945614.001).
  • [ISSN] 1018-9068
  • [Journal-full-title] Journal of investigational allergology & clinical immunology
  • [ISO-abbreviation] J Investig Allergol Clin Immunol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Immunoglobulin M; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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77. Matsuo T, Ohara N, Namba Y, Koshima I, Ida K, Kanazawa S: Ophthalmic artery embolization as pretreatment of orbital exenteration for conjunctival squamous cell carcinoma. Cardiovasc Intervent Radiol; 2009 May;32(3):554-7
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  • [Title] Ophthalmic artery embolization as pretreatment of orbital exenteration for conjunctival squamous cell carcinoma.
  • A 75-year-old Chinese man with a 7-year history of gradual increase of the left eye swelling showed a massive conjunctival tumor growing outwardly from the interpalpebral fissure and had no light perception in the left eye.
  • Magnetic resonance imaging showed orbital invasion of the tumor around the left eyeglobe.
  • Pathologically, well-differentiated squamous cell carcinoma proliferated in exophytic, papillary, and nested fashions, arising from the bulbar conjunctiva.
  • Tumor cells were also found in the conjunctival stroma around the vessels.
  • The sclera at the equator had a perforated site with tumor cell invasion, but no intraocular invasion was found.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Conjunctiva / blood supply. Conjunctival Neoplasms / therapy. Embolization, Therapeutic / methods. Ophthalmic Artery

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  • (PMID = 18704568.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Turner HC, Budak MT, Akinci MA, Wolosin JM: Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays. Invest Ophthalmol Vis Sci; 2007 May;48(5):2050-61
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  • [Title] Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays.
  • PURPOSE: To determine global mRNA expression levels in corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression.
  • METHODS: cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide array representing more than 22,000 transcripts.
  • The corresponding numbers of conjunctival epithelium transcripts were 592 and 211, respectively.
  • In the conjunctiva, the biological processes that were most prominent were related to innate immunity and melanogenesis.
  • The transcript comparison identified a substantial number of genes that have either not been identified previously or are not known to be highly expressed in these two epithelia, including testican-1, ECM1, formin, CRTAC1, and NQO1 in the cornea and, in the conjunctiva, sPLA(2)-IIA, lipocalin 2, IGFBP3, multiple MCH class II proteins, and the Na-Pi cotransporter type IIb.
  • CONCLUSIONS: Comparative gene expression profiling leads to the identification of many biological processes and previously unknown genes that are potentially active in the function of corneal and conjunctival epithelia.

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  • (PMID = 17460260.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY014878-03; United States / NEI NIH HHS / EY / R01 EY014878-03; United States / NEI NIH HHS / EY / R03EY015132; United States / NEI NIH HHS / EY / R01 EY014878; United States / NEI NIH HHS / EY / R03 EY015132; United States / NEI NIH HHS / EY / R01EY014878
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS217065; NLM/ PMC2909883
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79. Kraft ME, Glaeser H, Mandery K, König J, Auge D, Fromm MF, Schlötzer-Schrehardt U, Welge-Lüssen U, Kruse FE, Zolk O: The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci; 2010 May;51(5):2504-11
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  • OATP2A1 protein expression was most prominent in the RPE and in epithelial and endothelial cell layers of anterior segment tissues, such as cornea, conjunctiva, iris, and ciliary body, whereas OATP2B1 protein was additionally expressed in trabecular meshwork, Schlemm canal, and choroidal vasculature.

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  • (PMID = 20019365.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Organic Anion Transporters; 0 / Prostaglandins F, Synthetic; 0 / RNA, Messenger; 0 / SLCO2A1 protein, human; 0 / SLCO2B1 protein, human; 6Z5B6HVF6O / latanoprost
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80. Phillips TE, Sharp J, Rodgers K, Liu H: M cell-targeted ocular immunization: effect on immunoglobulins in tears, feces, and serum. Invest Ophthalmol Vis Sci; 2010 Mar;51(3):1533-9
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  • PURPOSE: This study investigates whether antigen-sampling M cells, present in the follicle-associated epithelium (FAE) above organized conjunctiva-associated lymphoid tissue in rabbits, bind and retro-transport secretory IgA (sIgA) from the tear film.
  • RESULTS: Endogenous sIgA was found associated with the apical membrane of conjunctival M cells.
  • CONCLUSIONS: Conjunctival M cells bind and translocate sIgA from the tear film.
  • Topical conjunctival immunization leads to generation of antigen-specific immunoglobulins from both local and distant mucosae and in serum.

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  • (PMID = 19892871.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R03 EY013779; United States / NEI NIH HHS / EY / EY13779
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Immunoglobulin A, Secretory; 0 / Immunoglobulin G; 0 / Immunoglobulin M
  • [Other-IDs] NLM/ PMC2868436
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81. Fatima A, Iftekhar G, Sangwan VS, Vemuganti GK: Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium. Eye (Lond); 2008 Sep;22(9):1161-7
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  • METHODS: Corneal and conjunctival pannus tissues from 29 patients undergoing ocular reconstruction with cultured limbal cell transplantation were included.
  • The medical records of these patients were reviewed for demographics, aetiologic diagnosis, type of injury, interval between the initial insult and excision of pannus, and medical history involving human amniotic membrane (HAM) or limbal transplantation.
  • Goblet cells were seen over the cornea in 64% cases; their absence was associated with squamous metaplasia of the conjunctiva and with long duration of insult.

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  • (PMID = 17558385.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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82. Mastropasqua L, Nubile M, Lanzini M, Carpineto P, Toto L, Ciancaglini M: Corneal and conjunctival manifestations in Fabry disease: in vivo confocal microscopy study. Am J Ophthalmol; 2006 Apr;141(4):709-18
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  • [Title] Corneal and conjunctival manifestations in Fabry disease: in vivo confocal microscopy study.
  • PURPOSE: To describe the microscopic corneal and conjunctival findings in patients with Fabry disease (FD) related keratopathy by using in vivo confocal microscopy.
  • Corneal and conjunctival morphology were assessed by means of a scanning slit corneal confocal white-light microscopy and confocal laser-scanning microscope.
  • In all patients, conjunctival epithelial involvement represented by bright roundish intracellular inclusions was evidenced, appearing more pronounced in tarsal than in bulbar conjunctiva.
  • Confocal microscopy may assist ophthalmologists in the diagnosis of FD-related ocular surface and corneal manifestations.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Corneal Diseases / diagnosis. Fabry Disease / diagnosis


83. Liang H, Baudouin C, Faure MO, Lambert G, Brignole-Baudouin F: Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay. Mol Vis; 2009;15:1690-9
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  • The ocular surface changes were investigated using slit-lamp examination, corneal in vivo confocal microscopy (IVCM) for cornea, limbus, conjunctiva/conjunctiva-associated lymphoid tissue (CALT) investigations, and conjunctival imprints for cytology and flow cytometry (FCM) analyses.
  • LCEm did not induce any obvious signs of toxicity on the rabbit ocular surface with results similar to those of PBS; moreover, the conjunctiva/CALT and cornea had almost normal aspects.
  • [MeSH-minor] Animals. Antigens, CD45 / metabolism. Cations. Conjunctiva / cytology. Conjunctiva / drug effects. Emulsions. Flow Cytometry. Immunohistochemistry. Lymphoid Tissue / drug effects. Male. Microscopy, Confocal. Rabbits

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  • (PMID = 19710954.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cations; 0 / Emulsions; 0 / Ophthalmic Solutions; 0 / Prostaglandins; 0 / Prostaglandins F, Synthetic; 6Z5B6HVF6O / latanoprost; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC2731833
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84. Kohl E, Hillenkamp J, Landthaler M, Szeimies RM: [Skin and eyes]. Hautarzt; 2009 Jan;60(1):63-74; quiz 75
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  • The differential diagnosis must include atopic and seborrhoeic eyelid dermatitis.
  • Various immunobullous disorders involve the conjunctiva with varying severity.
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19130027.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 44
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85. Dietlein TS, Jordan J, Krieglstein GK: [Lateral tube repositioning following a Baerveldt glaucoma implant. An alternative surgical procedure in the case of repeated conjunctival arrosion]. Ophthalmologe; 2007 Jun;104(6):508-10
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  • [Title] [Lateral tube repositioning following a Baerveldt glaucoma implant. An alternative surgical procedure in the case of repeated conjunctival arrosion].
  • Conjunctival arrosion of the silicone tube following glaucoma implant surgery is a postoperative complication that generally requires surgical revision by means of a sclera or dura patch with mobilization of adjacent conjunctiva.
  • We present a case of repeated conjunctival arrosion following Baerveldt implant surgery, in which successful revision was achieved over the course of a year by changing the insertion site of the silicone tube into the anterior chamber without touching the plate of the glaucoma implant.
  • [MeSH-major] Conjunctival Diseases / surgery. Glaucoma Drainage Implants / adverse effects. Postoperative Complications / surgery

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  • (PMID = 17342525.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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86. Schellini SA, Hoyama E, Shiratori CA, Sakamoto RH, Candeias JM: Lack of papillomavirus (HPV) in pterygia of a Brazilian sample. Arq Bras Oftalmol; 2006 Jul-Aug;69(4):519-21
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  • METHODS: Thirty-six patients with unilateral primary pterygia were submitted to excision of pterygia and a sample of normal conjunctiva.

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  • (PMID = 17119724.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / DNA, Viral
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87. Masanganise R, Rusakaniko S, Makunike R, Hove M, Chokunonga E, Borok MZ, Mauchaza BG, Chirenje M, Masanganise VN, Magure T: A historical perspective of registered cases of malignant ocular tumors in Zimbabwe (1990 to 1999). Is HIV infection a factor? Cent Afr J Med; 2008 May-Aug;54(5-8):28-32
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  • RESULTS: The age-adjusted annual incidence rates of squamous cell carcinoma of the conjunctiva had a more than 10-fold increase from 0.17 to 1.8 per 100,000 people during periods 1990 and 1999 respectively.


88. Law SK, Coleman AL, Caprioli J: Dynamic tube movement of Ahmed glaucoma valve. J Glaucoma; 2009 Oct-Nov;18(8):628-31
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  • RESULTS: In all 3 eyes, the fibrovascular capsule and the plate were noted to be stationary in the superior temporal fornix under the conjunctiva and did not move with movement of the eye.

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  • (PMID = 19826392.001).
  • [ISSN] 1536-481X
  • [Journal-full-title] Journal of glaucoma
  • [ISO-abbreviation] J. Glaucoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Yamauchi Y, Minoda H, Yokoi K, Maruyama K, Kumakura S, Usui M, Cruz JM, Fukutake K: Conjunctival flora in patients with human immunodeficiency virus infection. Ocul Immunol Inflamm; 2005 Jul-Aug;13(4):301-4
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  • [Title] Conjunctival flora in patients with human immunodeficiency virus infection.
  • PURPOSE: To compare the conjunctival flora of human immunodeficiency virus (HIV)-positive and HIV-negative patients.
  • Also, to assess the prophylactic effect of oral clarithromycin against Mycobacterium avium complex on the conjunctival flora of HIV-positive patients.
  • All participants had a detailed anterior segment examination, including conjunctival cultures and laboratory blood tests.
  • The effect of systemic antibiotic treatment on the conjunctival flora of patients with HIV infection was evaluated by chi-square analysis.
  • RESULTS: Bacterial organisms in the conjunctival sac were detected in four out of 28 (14.3%) eyes of HIV-positive patients treated with systemic clarithromycin and in 32 out of 66 (48.5%) eyes of HIV-positive patients without systemic clarithromycin treatment (p < 0.01).
  • No difference was observed in the types and proportions of organisms isolated from the conjunctiva between HIV-positive patients without systemic clarithromycin treatment and controls.
  • CONCLUSION: There was no difference between the conjunctival flora of HIV-negative and HIV-positive patients.
  • Systemic clarithromycin treatment decreased the conjunctival flora of HIV patients, including those who had a CD4 count that was less than 50/microl.
  • [MeSH-major] Conjunctiva / microbiology. HIV Infections / microbiology


90. Bianciotto C, Shields CL, Lally SE, Freire J, Shields JA: CyberKnife radiosurgery for the treatment of intraocular and periocular lymphoma. Arch Ophthalmol; 2010 Dec;128(12):1561-7
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  • The tissue location of the lymphoma was orbit (7 eyes), conjunctiva (3 eyes), choroid (2 eyes), and retina (2 eyes).
  • The lymphoma type was classified as extranodal marginal zone B-cell lymphoma in 7 eyes (50%), diffuse large B-cell lymphoma in 3 eyes (21%), follicular lymphoma in 2 eyes (14%), and benign reactive lymphoid hyperplasia in 2 eyes (14%).
  • Complete tumor resolution without local recurrence over a mean follow-up of 23 months was documented in all cases.
  • Radiation-associated adverse effects included mild dry eye in 2 patients and cataract in 1 patient with conjunctival lymphoma.

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  • (PMID = 21149780.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Blazek M, Havel E, Cerman J, Bĕlobrádková E, Dĕdek T, Pocepcov I: [Case report: fat embolism syndrome--grave handicap after traumatic long-bones fractures]. Rozhl Chir; 2009 Nov;88(11):649-55
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  • The very first day the organ failure and coma with negative CT occurred, then ARDS, petechiae into the skin of chest and conjunctiva, also embolic closure of a. centralis retinae.

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  • (PMID = 20662446.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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92. Chandra A, Maurya OP, Reddy B, Kumar G, Pandey K, Bhaduri G: Amniotic membrane transplantation in ocular surface disorders. J Indian Med Assoc; 2005 Jul;103(7):364-6, 368
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  • Recipient bed was prepared by removing the fibrovascular pannus and necrosed conjunctiva.
  • Initial proper assessment of limbal involvement, conjunctival necrosis and corneal involvement is the key to the management of acute cases.
  • Shield ulcers and persistent epithelial defect and ocular surface defects secondary to tumour excision showed excellent results.

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  • (PMID = 16366188.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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93. Lévy BI: [The importance of microcirculation and tissue perfusion in hypertension]. Curr Med Res Opin; 2005;21 Suppl 5:S1-6
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  • Such changes have been seen in the structure and density of the microvasculature of heart muscle, the conjunctiva and retina, and in the kidneys.

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  • (PMID = 16197644.001).
  • [ISSN] 0300-7995
  • [Journal-full-title] Current medical research and opinion
  • [ISO-abbreviation] Curr Med Res Opin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] England
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94. Schallenberg M, Niederdräing N, Steuhl KP, Meller D: [Topical Mitomycin C as a therapy of conjunctival tumours]. Ophthalmologe; 2008 Aug;105(8):777-84
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  • [Title] [Topical Mitomycin C as a therapy of conjunctival tumours].
  • [Transliterated title] Topisches Mitomycin C als Therapie konjunktivaler Tumore.
  • Surgical excision with tumour free margins is the gold standard for squamous cell and melanocytic tumours of the conjunctiva.
  • Present studies have shown that mitomycin C is a good option in squamous cell neoplasia of the conjunctiva.
  • However, further multi-centre studies and long-term follow-up are needed.The results in treating melanocytic tumours of the conjunctiva with MMC are less convincing.
  • MMC seems to be an option for the treatment of primary acquired melanosis (PAM); but, if the tumour is suspicious for melanoma primary chemotherapy with MMC is obsolete.
  • In these cases MMC can only be used as an adjuvant therapy, otherwise tumour control is not assured.
  • However, prospective randomized controlled trials are necessary for a final evaluation of MMC therapy in melanocytic tumours of the conjunctiva.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Carcinoma in Situ / drug therapy. Carcinoma, Squamous Cell / drug therapy. Conjunctival Neoplasms / drug therapy. Melanoma / drug therapy. Mitomycin / administration & dosage

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  • (PMID = 18618124.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
  • [Number-of-references] 62
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95. Kim SJ, Toma HS, Midha NK, Cherney EF, Recchia FM, Doherty TJ: Antibiotic resistance of conjunctiva and nasopharynx evaluation study: a prospective study of patients undergoing intravitreal injections. Ophthalmology; 2010 Dec;117(12):2372-8
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  • [Title] Antibiotic resistance of conjunctiva and nasopharynx evaluation study: a prospective study of patients undergoing intravitreal injections.
  • PURPOSE: To determine the baseline antibiotic susceptibility patterns of conjunctival and nasopharyngeal flora isolated from patients undergoing intravitreal (IVT) injections for choroidal neovascularization (CNV).
  • METHODS: Bilateral conjunctival and unilateral nasopharyngeal cultures on the treatment side were taken before application of any topical medications.
  • RESULTS: A total of 57 bacterial isolates were obtained from the conjunctiva of 48 eyes.
  • [MeSH-major] Anti-Bacterial Agents / pharmacology. Bacteria / isolation & purification. Conjunctiva / microbiology. Drug Resistance, Multiple, Bacterial. Nasopharynx / microbiology

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  • [Copyright] Copyright © 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20656351.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Anti-Bacterial Agents
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96. Gill RF, Pirockinaite G, O'Sullivan NL, Montgomery PC: Nasal-associated lymphoid tissue is not an absolute requirement for the induction of rat tear IgA antibody responses. Curr Eye Res; 2010 Jan;35(1):1-8
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  • CONCLUSIONS: These results indicate that particulate antigen can be taken up by the conjunctiva and transported to the draining lymph nodes, showing that antigen does not need to access nasal-associated lymphoid tissue to induce tear IgA antibody responses.

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  • (PMID = 20021248.001).
  • [ISSN] 1460-2202
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE015277; United States / NEI NIH HHS / EY / EY14695
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Dinitrophenols; 0 / Haptens; 0 / Immunoglobulin A, Secretory; 0 / Immunoglobulin G; 0 / Serum Albumin, Bovine; 0 / dinitrophenyl-bovine serum albumin
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97. Ng J, Coroneo MT, Wakefield D, Di Girolamo N: Ultraviolet radiation and the role of matrix metalloproteinases in the pathogenesis of ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci; 2008 Dec;49(12):5295-306
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  • [Title] Ultraviolet radiation and the role of matrix metalloproteinases in the pathogenesis of ocular surface squamous neoplasia.
  • PURPOSE: Ocular surface squamous neoplasia (OSSN) is an uncommon tumor of the corneal and conjunctival epithelium associated with risk of permanent visual impairment.
  • The purposes of this study were to (1) identify and localize potential mediators in tissue from patients with OSSN and (2) culture human dysplastic conjunctival epithelial cells (DCECs) to determine their responsiveness to ultraviolet (UV)-B radiation compared with normal conjunctival epithelial cells (NCECs).
  • METHODS: Immunohistochemical analysis was performed on OSSN (n = 23) and normal conjunctival (n = 17) tissue to identify matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs).
  • RESULTS: A higher proportion of diseased specimens stained for MMP-1 (83%), MMP-3 (86%), TIMP-2 (87%), and TIMP-3 (83%) compared with normal conjunctiva (41%, 41%, 47%, and 53%, respectively).
  • [MeSH-major] Carcinoma in Situ / enzymology. Conjunctiva / radiation effects. Conjunctival Neoplasms / enzymology. Epithelial Cells / radiation effects. Matrix Metalloproteinases / metabolism. Ultraviolet Rays
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Annexin A5 / metabolism. Apoptosis / radiation effects. Cell Survival. Female. Flow Cytometry. Gene Expression Regulation, Enzymologic / physiology. Humans. Immunoenzyme Techniques. Male. Middle Aged. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Inhibitor of Metalloproteinases / genetics. Tissue Inhibitor of Metalloproteinases / metabolism. Tumor Cells, Cultured

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  • (PMID = 18641285.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A5; 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases
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98. Shin SY, Lee YJ: Conjunctival changes induced by LASIK suction ring in a rabbit model. Ophthalmic Res; 2006;38(6):343-9
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  • [Title] Conjunctival changes induced by LASIK suction ring in a rabbit model.
  • PURPOSE: To study histopathological changes in rabbit conjunctiva after suction ring application.
  • At all time points, conjunctival epithelium showed no positive staining for p65.
  • CONCLUSION: The transient elevation of pressure induced by a suction ring is sufficient to cause conjunctival damage.
  • These histological results support the finding that conjunctival damage caused by suction ring application is one of many etiologies of dry eye syndrome following laser in situ keratomileusis.
  • [MeSH-major] Conjunctival Diseases / etiology. Keratomileusis, Laser In Situ / instrumentation. Suction / adverse effects

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17047406.001).
  • [ISSN] 0030-3747
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Mucins; 0 / Synaptotagmin I; P4448TJR7J / Alcian Blue
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99. Mrugacz M, Zak J, Bakunowicz-Lazarczyk A, Wysocka J, Minarowska A: Flow cytometric analysis of HLA-DR antigen in conjunctival epithelial cells of patients with cystic fibrosis. Eye (Lond); 2007 Aug;21(8):1062-6
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  • [Title] Flow cytometric analysis of HLA-DR antigen in conjunctival epithelial cells of patients with cystic fibrosis.
  • PURPOSE: Cystic fibrosis (CF) is an autosomal-recessive genetic disorder.
  • The aim of this study was to investigate the expression of HLA-DR on conjunctival epithelial cells from patients with CF.
  • Tear film break-up time (TBUT), Schirmer test, lissamine green staining, and conjunctival impression cytology were carried out.
  • CONCLUSION: These results suggest that conjunctival epithelial cells play an important proinflammatory role in ocular changes in CF patients.
  • HLA-DR measurement might be a useful method for monitoring of inflammatory processes in the conjunctiva and could be helpful in the use of anti-inflammatory drugs in the treatment of ocular findings in CF patients.


100. Lima CS, Rocha EM, Silva NM, Sonatti MF, Costa FF, Saad ST: Risk factors for conjunctival and retinal vessel alterations in sickle cell disease. Acta Ophthalmol Scand; 2006 Apr;84(2):234-41
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  • [Title] Risk factors for conjunctival and retinal vessel alterations in sickle cell disease.
  • PURPOSE: The aim of this study was to clarify whether the clinical, laboratory and genetic aspects of sickle cell disease (SCD) influence the occurrence of vessel alterations in the conjunctiva and retina.
  • RESULTS: Conjunctival vessel alteration (CVA) was not influenced by age, gender, HbF estimation, serum creatinine and albuminuria levels, GFR values, beta-globin gene haplotypes or alpha-thalassaemia.
  • [MeSH-major] Anemia, Sickle Cell / physiopathology. Conjunctiva / blood supply. Retinal Vessels / physiopathology

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  • (PMID = 16637843.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9034-63-3 / Fetal Hemoglobin; AYI8EX34EU / Creatinine
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