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1. Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD: Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev; 2002 Oct;11(10 Pt 1):1012-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?
  • Recent studies have suggested that hyperplastic polyps may be benign precursor lesions for a distinct subset of colorectal tumors.
  • We conducted a clinic-based case-control study to evaluate risk factors for hyperplastic polyps.
  • Cases with hyperplastic polyps (n = 219), adenomas (n = 437), and both types of polyps (n = 138), along with colonoscopy-negative controls (n = 708), were identified at a gastroenterology practice in the Minneapolis area during 1991-1994.
  • Risk factors for hyperplastic and adenomatous polyps were generally similar to those for colorectal cancer.
  • Male sex, smoking, and alcohol consumption were associated with increased risk of all polyp groups; nonsteroidal anti-inflammatory drug use, hormone replacement therapy use, and calcium intake were associated with reduced risk.
  • There was no apparent association between increasing age and hyperplastic polyp risk (P = 0.21) in this analysis, although it was a strong risk factor for adenoma (P < 0.001).
  • The odds ratio (OR) for hyperplastic polyps associated with >25 pack-years of smoking was 4.1 [95% confidence interval (CI), 2.2-7.6], whereas the OR for adenoma alone was 1.3 (95% CI, 0.8-2.3).
  • The OR estimate for individuals diagnosed with both polyp types was 4.2 (95% CI, 1.9-9.3).
  • These results suggest, as one possibility, that the consistent association of adenoma and smoking observed in previous studies may be partially attributable to the inclusion of individuals with both adenomas and hyperplastic polyps in the adenoma case group.
  • To the contrary, individuals with both polyp types may be expressing a phenotype distinct from those who have only adenomas and should be considered separately.
  • Further studies are necessary to establish which polyp phenotypes are related to smoking.
  • Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential.
  • [MeSH-major] Adenomatous Polyps / etiology. Colonic Neoplasms / etiology. Colonic Polyps / etiology. Smoking / adverse effects
  • [MeSH-minor] Adult. Aged. Alcohol Drinking / adverse effects. Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Case-Control Studies. Female. Hormone Replacement Therapy / adverse effects. Humans. Hyperplasia. Male. Middle Aged. Phenotype. Risk Factors. Sex Factors

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  • (PMID = 12376501.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5-T32-CA09168; United States / NIEHS NIH HHS / ES / ES-07033; United States / NCI NIH HHS / CA / P01 CA 50405; United States / NCI NIH HHS / CA / T32 CA09661
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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2. Taniguchi E, Nakajima H, Hongyo T, Fukuda K, Li LY, Kurooka M, Matsuda H, Nomura T: Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice. Cancer Lett; 2002 Aug 28;182(2):127-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice.
  • N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatments for a long period induced morphological and molecular alterations in the benign human colorectal polyps which were maintained in the severe combined immunodeficient C.B17/N-scid/scid mice.
  • Thirty four xenografts of colorectal polyps from five solitary polyp and three familial polyposis patients were examined for K-ras and p53 mutations.
  • Additional and new K-ras mutations were also induced in two polyps in which K-ras mutation had pre-existed. p53 mutations were not observed in both MNNG-treated and untreated groups.
  • The results indicate that K-ras mutation plays an important role in human colorectal carcinogenesis as is the case in experimental animals.
  • [MeSH-major] Colonic Polyps / pathology. Genes, p53. Genes, ras / genetics. Methylnitronitrosoguanidine / toxicity. Mutagenesis. Mutagens / toxicity
  • [MeSH-minor] Animals. Codon / drug effects. Codon / genetics. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Disease Models, Animal. Humans. Mice. Mice, SCID. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Time Factors. Transplantation, Heterologous

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  • (PMID = 12048157.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Codon; 0 / Mutagens; 12H3O2UGSF / Methylnitronitrosoguanidine
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