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Items 1 to 54 of about 54
1. Doğanavşargil B, Serin G, Akyildiz M, Ertan Y, Tunçyürek M: Benign fibroblastic polyp of the colon: a case report. Turk J Gastroenterol; 2009 Dec;20(4):287-90
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  • [Title] Benign fibroblastic polyp of the colon: a case report.
  • There are a fair number of polyps in the gastrointestinal tract, which cannot be classified under a certain category.
  • We report herein a 50-year-old man with a 6-mm sigmoidal polyp; he had been operated previously for rectal carcinoma.
  • The polyp was characterized by benign-appearing spindle cells in the lamina propria leading to a wide separation and disorganization of the colonic crypts, accompanied by focal erosion and restricted areas suspicious for inflammatory fibroid polyp.
  • The histologic features were found consistent with the disease spectrum of 'benign fibroblastic polyp of the colon' defined by Eslami-Varzaneh et al.
  • [MeSH-major] Colon, Sigmoid / pathology. Colonic Polyps / pathology. Fibroblasts / pathology. Mucous Membrane / pathology

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  • (PMID = 20084575.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 9
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2. Meniconi RL, Caronna R, Benedetti M, Fanello G, Ciardi A, Schiratti M, Papini F, Farelli F, Dinatale G, Chirletti P: Inflammatory myoglandular polyp of the cecum: case report and review of literature. BMC Gastroenterol; 2010;10:10
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  • [Title] Inflammatory myoglandular polyp of the cecum: case report and review of literature.
  • BACKGROUND: Inflammatory myoglandular polyp (IMGP) is a rare non-neoplastic polyp of the large bowel, commonly with a distal localization (rectosigmoid), obscure in its pathogenesis.
  • A colonoscopy identified a red, sessile, lobulated polyp of the cecum, 4.2 cm in diameter, partially ulcerated.
  • The histological examination of the biopsy revealed the presence of inflammatory granulation tissue with lymphocytic and eosinophil infiltration associated to a fibrous stroma: it was diagnosed as inflammatory fibroid polyp.
  • Considering the polyp's features (absence of a peduncle and size) that could increase the risk of a polypectomy, a surgical resection was performed.
  • Histological examination of the specimen revealed inflammatory granulation tissue in the lamina propria, hyperplastic glands with cystic dilatations, proliferation of smooth muscle and multiple erosions on the polyp surface: this polyp was finally diagnosed as IMGP.
  • There was also another little polyp next to the ileocecal valve, not revealed at the colonoscopy, 0.8 cm in diameter, diagnosed as tubulovillous adenoma with low grade dysplasia.
  • It is a benign lesion of unknown pathogenesis and must be considered different from other non-neoplastic polyps of the large bowel such as inflammatory cap polyps (ICP), inflammatory cloacogenic polyps, juvenile polyps (JP), inflammatory fibroid polyps (IFP), polyps secondary to mucosal prolapse syndrome (MPS), polypoid prolapsing mucosal folds of diverticular disease.
  • [MeSH-major] Cecum / pathology. Cecum / surgery. Colonic Polyps / diagnosis. Colonic Polyps / surgery

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  • (PMID = 20102635.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2828397
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3. Lee SH, Lee KS, Lee JY, Ji JH, Park JK, Park YS, Hwang JH, Kim JW, Jung SH, Kim N, Lee DH, Kim SG, Kim JS, Jung HC, Song IS: [Clinical usefulness of fecal occult blood test as a screening method for asymptomatic patients with colon polyps]. Korean J Gastroenterol; 2006 Dec;48(6):388-94
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  • [Title] [Clinical usefulness of fecal occult blood test as a screening method for asymptomatic patients with colon polyps].
  • BACKGROUND/AIMS: Detection of asymptomatic benign colon polyp is increasing because colonoscopy is widely used as a screening and diagnostic method.
  • Fecal occult blood test is usually performed for the selection of patients requiring colonoscopy as well as mass screening for colon cancer.
  • The aim of this study was to investigate the usefulness of fecal occult blood test performed prior to colonoscopy as a screening method of benign colon polyps.
  • METHODS: Clinical characteristics of patients with polyps were evaluated according to the fecal occult blood test results in patients who underwent one-day fecal occult blood test and colonoscopic polypectomies from May 2003 to October 2004, retrospectively.
  • In univariate analysis, there was a significant difference in polyp size (p=0.02) and location (p=0.03) according to the presence of positive fecal occult blood tests.
  • In addition, age of the patient (p=0.046), polyp size (mean, p=0.04; largest, p<0.01) and the number of polyps (p=0.045) were significantly different.
  • However, in multivariate analysis, only polyp size larger than 20 mm was significantly related with positive fecal occult blood test with estimated odds ratio of 4.71.
  • CONCLUSIONS: Fecal occult blood test has limitations as a screening test in asymptomatic patients with colon polyps, except for colon polyps larger than 20 mm in size.
  • [MeSH-major] Colonic Polyps / diagnosis. Occult Blood
  • [MeSH-minor] Colonic Neoplasms / diagnosis. Colonoscopy. Female. Humans. Male. Mass Screening. Sensitivity and Specificity

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  • (PMID = 17189921.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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4. Brevet M, Chatelain D, Bartoli E, Geslin G, Delcenserie R, Braillon A, Sevestre H, Dupas JL: Colonic pseudolipomatosis: clinical, endoscopical and pathological features in nine cases. Gastroenterol Clin Biol; 2006 Jan;30(1):9-13
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  • [Title] Colonic pseudolipomatosis: clinical, endoscopical and pathological features in nine cases.
  • Colonic pseudolipomatosis is a rare and benign condition.
  • METHODS: All cases of colonic pseudolipomatosis seen between February 2002 and June 2004 at the Amiens Universisty Hospital were identified and analyzed.
  • RESULTS: During this period, 2099 colonoscopies were performed and 9 cases of colonic pseudolipomatosis were diagnosed (0.4%).
  • In three patients, colonic pseudolipomatosis was a fortuitous discovery during colonoscopy for polyp surveillance.
  • They extended over a two to 20 cm-long area, located in the right (two patients), transverse (four patients) or left colon (three patients).
  • CONCLUSION: Colonic pseudolipomatosis is rare.
  • [MeSH-major] Colonic Diseases / diagnosis. Colonic Diseases / pathology. Lipomatosis / diagnosis. Lipomatosis / pathology

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  • (PMID = 16514376.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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5. Kalof AN, Pritt B, Cooper K, Hyman NH, Blaszyk H: Benign fibroblastic polyp of the colorectum. J Clin Gastroenterol; 2005 Oct;39(9):778-81
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  • [Title] Benign fibroblastic polyp of the colorectum.
  • GOALS: We present the clinicopathologic features, endoscopic appearance, and ultrastructure of a newly described mesenchymal polyp of the colorectum, termed benign fibroblastic polyp.
  • RESULTS: Benign fibroblastic polyps appear endoscopically throughout the colorectum as submucosal lesions with a hyperplastic surface component.
  • These lesions are histologically and ultrastructurally distinct, but overlap with other mesenchymal polyps warrants additional immunohistochemical studies for definitive classification.
  • CONCLUSIONS: Benign fibroblastic polyps of the colorectum comprise a recently described distinct entity of mesenchymal polyps that appear to follow an indolent clinical course.
  • [MeSH-major] Colonic Polyps / pathology. Fibroblasts. Intestinal Polyps / pathology. Rectal Diseases / pathology

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  • (PMID = 16145339.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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6. Groisman GM, Polak-Charcon S, Appelman HD: Fibroblastic polyp of the colon: clinicopathological analysis of 10 cases with emphasis on its common association with serrated crypts. Histopathology; 2006 Mar;48(4):431-7
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  • [Title] Fibroblastic polyp of the colon: clinicopathological analysis of 10 cases with emphasis on its common association with serrated crypts.
  • AIMS: To describe the clinical and pathological features of 10 further cases of fibroblastic polyps (FP), a recently described, distinctive type of colorectal mucosal polyp.
  • Eight of the polyps were located in the sigmoid colon.
  • Five cases were associated with hyperplastic polyps.
  • Eight polyps represented mixed fibroblastic/hyperplastic polyps as they contained serrated (hyperplastic) crypts.
  • CONCLUSIONS: FP is a distinctive type of benign mucosal colorectal polyp characterized by its distal location, small size, frequent association with hyperplastic polyps, distinct morphological appearance and typical immunonegativity for markers of specific differentiation.
  • FP with serrated crypts (mixed fibroblastic/hyperplastic polyp) represents a frequent variant of this lesion.
  • Pathologists should recognize FP and discriminate it from other types of colorectal polyps.
  • [MeSH-major] Colon / pathology. Colonic Polyps / pathology

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  • (PMID = 16487365.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vimentin
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7. Kim HJ, Kang MK, Lee HS, Kim DS, Lee DH: Signet ring cell carcinoma arising from a solitary juvenile polyp in the colon. J Korean Soc Coloproctol; 2010 Oct;26(5):365-7

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  • [Title] Signet ring cell carcinoma arising from a solitary juvenile polyp in the colon.
  • Juvenile polyps are relatively common polyps that affect predominantly young patients and may occur in isolated, multiple, and/or familial forms.
  • They have been considered to be benign lesions without neoplastic potential, but for patients with multiple juvenile polyposis, the cumulative malignant risk is greater than fifty percents.
  • In patients with a solitary polyp, the risks are minimal, and only a few cases of malignant change from a solitary juvenile polyp have been reported.
  • We describe the case of a twenty one year old female with one solitary juvenile polyp, which contained a signet ring cell carcinoma in the mucosal layer.

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  • (PMID = 21152141.001).
  • [ISSN] 2093-7830
  • [Journal-full-title] Journal of the Korean Society of Coloproctology
  • [ISO-abbreviation] J Korean Soc Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2998024
  • [Keywords] NOTNLM ; Carcinoma / Colonic polyps / Signet ring cell / Solitary juvenile polyps
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8. Qayyum A, Sawan AS: Profile of colonic biopsies in King Abdul Aziz University Hospital, Jeddah. J Pak Med Assoc; 2009 Sep;59(9):608-11
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  • [Title] Profile of colonic biopsies in King Abdul Aziz University Hospital, Jeddah.
  • OBJECTIVE: To scrutinize all colonic biopsies and document the prevalence and pattern of various colonic diseases amongst the patients presenting at a tertiary care hospital of Western Saudi Arabia.
  • METHODS: We examined the record of all colonic biopsies, processed at Histopathology Department of King Abdul Aziz University Hospital; Jeddah from January 2002 to July 2007.
  • RESULTS: The colonic biopsies received during the study period were 711.
  • Biopsies showing inflammatory, nonspecific/infective and other miscellaneous colonic lesions were 477.
  • Of the 107 benign polyps seen, the most dominant was adenomatous polyp.
  • Tubular adenomas are the most common type of polyps and adenocarcinoma is the most common malignancy of the colon.
  • [MeSH-major] Colonic Diseases / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adolescent. Adult. Aged. Child. Child, Preschool. Colitis, Ulcerative / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Female. Humans. Male. Middle Aged. Prevalence. Saudi Arabia / epidemiology. Young Adult

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  • (PMID = 19750855.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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9. Agaimy A, Stoehr R, Vieth M, Hartmann A: Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations. Am J Surg Pathol; 2010 Nov;34(11):1663-71
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  • [Title] Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.
  • Colorectal fibroblastic polyp and intramucosal perineurioma are 2 synonyms for a recently described benign mucosal lesion with a predilection for the rectosigmoid colon.
  • The pathogenesis of fibroblastic polyp/intramucosal perineurioma and the nature of serrated crypts observed in them are poorly understood.
  • We analyzed the clinicopathological features of 29 fibroblastic polyps and investigated them for the first time for mutations known to be involved in serrated colorectal epithelial polyps (BRAF, KRAS, and PIK3CA).
  • All lesions represented asymptomatic solitary polyps (mean size 3.5 mm) localized predominantly in the rectosigmoid colon (81%).
  • Hyperplastic polyps, classical adenoma, and sessile serrated adenoma/lesion coexisted in 12 (44%), 12 (44%), and 5 (17%) patients, respectively.
  • Our results indicate that serrated fibroblastic polyps/intramucosal perineuriomas represent a unique type of mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma).
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Epithelial Cells / pathology. Fibroblasts / pathology. Intestinal Mucosa / pathology. Mutation. Nerve Sheath Neoplasms / pathology. Proto-Oncogene Proteins B-raf / genetics. Stromal Cells / pathology

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  • (PMID = 20962618.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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10. Goldstein PJ, Cabanas J, da Silva RG, Sugarbaker PH: Pseudomyxoma peritonei arising from colonic polyps. Eur J Surg Oncol; 2006 Sep;32(7):764-6
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  • [Title] Pseudomyxoma peritonei arising from colonic polyps.
  • This manuscript describes this disease arising from a benign or malignant colonic polyp.
  • METHODS: From a database of over 1000 pseudomyxoma peritonei patients and colorectal carcinomatosis patients, three cases were identified in which the primary tumor site was a colonic polyp.
  • RESULTS: In a review of the clinical management of these patients, all three had an event whereby neoplastic cells from the surface of the colonic polyp could have gained access to the free peritoneal cavity.
  • CONCLUSIONS: Colonic polyps can serve as a source of dysplastic cells whereby pseudomyxoma peritonei can result.
  • Caution to prevent seeding to the free peritoneal cavity during surgery for colonic polyps should be observed.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasm Seeding. Peritoneal Neoplasms / secondary. Pseudomyxoma Peritonei / etiology

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  • (PMID = 16765563.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Zmora O, Benjamin B, Reshef A, Neufeld D, Rosin D, Klein E, Ayalon A, Shpitz B: Laparoscopic colectomy for colonic polyps. Surg Endosc; 2009 Mar;23(3):629-32
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  • [Title] Laparoscopic colectomy for colonic polyps.
  • BACKGROUND: Benign colonic polyps not amenable to colonoscopic resection or those containing carcinoma require surgical excision.
  • The aim of this study was to review our experience with the laparoscopic approach for retrieval of colonic polyps with specific emphasis on safety, feasibility, and tumor localization.
  • METHODS: Retrospective chart review of all patients who underwent laparoscopic colectomy for colonic polyps was performed.
  • RESULTS: Forty-nine patients (22 males, 27 males, mean age 66 years) underwent laparoscopic colectomy for colonic polyps.
  • Indications for surgery were presumably benign polyps in 38 patients, and superficial carcinoma in a polyp, diagnosed by colonoscopy, in 11; twenty-three patients underwent preoperative localization procedures.
  • In 19% of patients who did not have preoperative localization, difficulties locating the polyp were encountered during surgery, requiring intraoperative endoscopy or conversion to laparotomy.
  • In 7 of the 38 patients with presumably benign lesion, colon cancer was diagnosed in the colectomy specimen.
  • CONCLUSIONS: Laparoscopic surgery for the treatment of colonic polyps seems to be feasible and safe, with a low complication rate.
  • Although one-fifth of presumably benign polyps harbored cancer, none of these patients had positive lymph nodes.
  • [MeSH-major] Colectomy / methods. Colonic Polyps / surgery. Laparoscopy / methods

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  • (PMID = 19067054.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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12. Blumberg D: Laparoscopic colon resection of benign polyps: high grade dysplasia on endoscopic biopsy and polyp location predict risk of cancer. Surg Laparosc Endosc Percutan Tech; 2009 Jun;19(3):255-7
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  • [Title] Laparoscopic colon resection of benign polyps: high grade dysplasia on endoscopic biopsy and polyp location predict risk of cancer.
  • BACKGROUND: To ensure that an oncologic resection is not compromised, laparoscopic surgery is not recommended for colon cancer patients during the learning curve.
  • Although patients with colon polyps are frequently selected as "learning cases," several studies have found a high incidence of occult cancers in this subset of patients questioning the safety of this approach.
  • A retrospective review was performed of laparoscopic resections for colonic polyps to determine the incidence of occult cancer and, clinical and pathologic factors predictive of cancer.
  • METHODS AND RESULTS: From January 2004 and September 2007, 44 colectomies were performed for colonic polyps.
  • High-grade dysplasia on endoscopic biopsy and polyp location distal to the splenic flexure was associated with a significantly (P<0.05) increased risk of cancer.
  • Forty-three percent of cancers were detected in polyps with high-grade dysplasia compared with 8% of polyps without dysplasia on biopsy.
  • Polyps distal to the splenic flexure had a 43% rate of occult cancers detected compared with 8% in polyps proximal to the splenic flexure.
  • CONCLUSIONS: Colonic polyps with high-grade dysplasia on endoscopic biopsy and polyps located distal to the splenic flexure are associated with the highest risk of cancer and may not be appropriate cases during the learning curve.
  • [MeSH-major] Biopsy / methods. Colectomy / methods. Colonic Neoplasms / pathology. Colonic Polyps / surgery. Colonoscopy / methods. Laparoscopy / methods

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  • (PMID = 19542857.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Sakamoto T, Kato H, Okabe T, Ohya T, Iesato H, Yokomori T, Haga SS: A large inflammatory fibroid polyp of the colon treated by endoclip-assisted endoscopic polypectomy: A case report. Dig Liver Dis; 2005 Dec;37(12):968-72
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  • [Title] A large inflammatory fibroid polyp of the colon treated by endoclip-assisted endoscopic polypectomy: A case report.
  • Inflammatory fibroid polyp is a rare benign polypoid lesion of the gastrointestinal tract.
  • Histologically, inflammatory fibroid polyp is characterised by an admixture of numerous small vessels, fibroblasts and oedematous connective tissue, accompanied by marked inflammatory infiltration by eosinophils.
  • A pedunculated and reddish polyp was found endoscopically in the ascending colon.
  • The polyp was large but was resected endoscopically without any problems.
  • Histologically, the abnormal tissue of the polyp was located in the submucosal and mucosal layer.
  • These findings are compatible with the histological diagnosis of inflammatory fibroid polyp.
  • The surgical margin of the polyp was free of the tumour.
  • Inflammatory fibroid polyp is more commonly found in the stomach or small intestine, and rarely in the colon, and therefore our case is a rare example of large and pedunculated colonic inflammatory fibroid polyp, which was treated successfully by endoscopic polypectomy.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy. Occult Blood

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  • (PMID = 16243012.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Zwielly A, Mordechai S, Sinielnikov I, Salman A, Bogomolny E, Argov S: Advanced statistical techniques applied to comprehensive FTIR spectra on human colonic tissues. Med Phys; 2010 Mar;37(3):1047-55
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  • [Title] Advanced statistical techniques applied to comprehensive FTIR spectra on human colonic tissues.
  • PURPOSE: Colon cancer is a major public health problem due to its high disease rate and death toll worldwide.
  • In the present study, the authors investigated the potential of FTIR microscopy to define spectral changes among normal, polyp, and cancer human colonic biopsied tissues.
  • METHODS: A large database of FTIR microscopic spectra was compiled from 230 human colonic biopsies.
  • The database was divided into five subgroups: Normal, cancerous tissues, and three stages of benign colonic polyps, namely, mild, moderate, and severe polyps, which are precursors of carcinoma.
  • RESULTS: While PCA analysis shows only partial success in distinguishing among cancer, polyp, and the normal tissues, multivariate analysis (e.g., LDA) shows a promising distinction even within the polyp subgroups.
  • CONCLUSIONS: Good classification accuracy among normal, polyp, and cancer groups was achieved with a success rate of approximately 85%.
  • These results strongly support the potential of developing FTIR microscopy as a simple, reagent-free tool for early detection of colon cancer and, in particular, for discriminating among the benign premalignant colonic polyps having increasing degrees of dysplasia severity (mild, moderate, and severe).
  • [MeSH-major] Algorithms. Biomarkers, Tumor / analysis. Colonic Neoplasms / chemistry. Colonic Neoplasms / diagnosis. Diagnosis, Computer-Assisted / methods. Spectroscopy, Fourier Transform Infrared / methods

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  • (PMID = 20384240.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Macaigne G, Boivin JF, Cheaib S, Auriault ML, Deplus R: [Single filiform polyp revealed by severe haemorrhage in a patient with normal colon. Report of a case and review of the literature]. Gastroenterol Clin Biol; 2006 Jun-Jul;30(6-7):913-5
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  • [Title] [Single filiform polyp revealed by severe haemorrhage in a patient with normal colon. Report of a case and review of the literature].
  • [Transliterated title] Polype filiforme unique développé dans un côlon normal et révélé par une hémorragie digestive sévère. A propos d'un cas et revue de la littérature.
  • Filiform polyposis or giant inflammatory polyp is an uncommon benign lesion that has principally been reported in patients with evidence of inflammatory bowel disease, Crohn's disease or ulcerative colitis.
  • More rarely, PF found in association with colonic non specific inflammation.
  • PF has rarely been reported in patients without previous colonic disease.
  • We report the case of a 60-year-old woman without history of colonic disease who presented a PF revealed by hematochesia.
  • [MeSH-major] Colonic Polyps / diagnosis. Gastrointestinal Hemorrhage / etiology

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  • (PMID = 16885880.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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16. Kim BC, Cheon JH, Lee SK, Kim TI, Kim H, Kim WH: Needle knife-assisted endoscopic polypectomy for a large inflammatory fibroid colon polyp by making its stalk into an omega shape using an endoloop. Yonsei Med J; 2008 Aug 30;49(4):680-6
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  • [Title] Needle knife-assisted endoscopic polypectomy for a large inflammatory fibroid colon polyp by making its stalk into an omega shape using an endoloop.
  • Colonic inflammatory fibroid polyp (IFP) is an uncommon benign polypoid lesion, which is composed of fibroblasts, numerous small vessels and edematous connective tissue with marked eosinophilic inflammatory cell infiltration.
  • This condition is frequently detected in the stomach and small intestine, but uncommon in the colon.
  • Although IFP is a benign lesion, surgical resections are performed in most colonic cases because the polyps are usually too large to resect endoscopically.
  • Here, we present a case of IFP in the descending colon successful endoscopically resected using a novel technique of trapping its stalk with an endoloop, forming the stalk into an omega shape, and then dissecting the stalk with a needle knife.
  • [MeSH-major] Colonic Polyps / pathology. Colonic Polyps / surgery. Colonoscopy / methods. Leiomyoma / surgery

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  • (PMID = 18729316.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2615300
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17. Calabuig-Fariñas S, López-Guerrero JA, Ribera MJ, Navarro S, Ramos D, Pellín A, Llombart-Bosch A: Inflammatory fibroid polyp of the small bowel with a mutation in exon 12 of PDGFR alpha. Virchows Arch; 2009 Mar;454(3):327-31
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  • [Title] Inflammatory fibroid polyp of the small bowel with a mutation in exon 12 of PDGFR alpha.
  • Inflammatory fibroid polyp (IFP) is a benign reactive uncommon submucosal lesion of the gastrointestinal tract, the small intestine being the most common site of origin.
  • [MeSH-major] Colonic Polyps / genetics. Colonic Polyps / pathology. Leiomyoma / genetics. Leiomyoma / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics

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  • (PMID = 19189127.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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18. Lipof T, Bartus C, Sardella W, Johnson K, Vignati P, Cohen J: Preoperative colonoscopy decreases the need for laparoscopic management of colonic polyps. Dis Colon Rectum; 2005 May;48(5):1076-80
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  • [Title] Preoperative colonoscopy decreases the need for laparoscopic management of colonic polyps.
  • PURPOSE: Patients are commonly referred to surgeons for surgical resection of polyps that cannot be excised colonoscopically.
  • Second, and more importantly, many of these polyps can be removed endoscopically by an experienced colorectal surgeon, avoiding unnecessary colon resection.
  • Over a period of five years, we have reviewed preoperative colonoscopy in patients who were referred for surgical treatment of benign polyps.
  • METHODS: From January 1999 through September 2003 all patients referred for surgical resection of a benign polyp were consecutively entered into a database by a single group of colorectal surgeons.
  • All patients underwent preoperative colonoscopy on the day before the planned colon resection.
  • The referral and preoperative colonoscopy reports and all pathology results were reviewed to record the polyp size, location, histology, and subsequent treatment.
  • The average size of the polyps was 24 mm (range, 10-60 mm).
  • The location of the polyp as determined by preoperative colonoscopy differed from the location noted on referral colonoscopy in nine patients (13 percent).
  • Of the 48 who underwent surgery, 23 (47 percent) had a colonic tattoo placed, at the discretion of the surgeon.
  • Of the 48 patients who underwent surgery, 45 (94 percent) underwent laparoscopic colon resection.
  • CONCLUSIONS: We concluded that patients referred for surgical resection of a polyp should undergo repeat colonoscopy preoperatively, given that in our study one-third of patients were spared unnecessary colectomy.
  • In addition, repeat endoscopy by the operating surgeon offers an opportunity to confirm the location of the lesion and place a colonic tattoo to facilitate laparoscopic resection.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / methods. Laparoscopy / utilization

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  • (PMID = 15933894.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Metser U, Miller E, Lerman H, Even-Sapir E: Benign nonphysiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence. AJR Am J Roentgenol; 2007 Nov;189(5):1203-10
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  • [Title] Benign nonphysiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence.
  • OBJECTIVE: The objective of our study was to characterize benign lesions showing increased 18F-FDG uptake and to determine their incidence on whole-body FDG PET/CT performed in oncologic patients.
  • In addition, the performance of PET alone and PET/CT in characterizing lesions as benign was compared.
  • MATERIALS AND METHODS: A retrospective review of 1,134 consecutive reports of PET/CT studies performed in patients with proven or suspected malignancy over a 6-month period yielded 289 patients with 313 lesions that showed increased FDG uptake but were suspected to be benign (nonphysiologic) or indeterminate.
  • For each lesion, a decision was made as to whether a benign diagnosis could be obtained by the CT part of the study, the PET pattern, or clinical correlation, or whether histologic sampling was necessary.
  • The performance of PET alone and PET/CT for characterizing lesions as benign was compared.
  • Two hundred twenty-nine of the lesions were assessed further: 210 were benign and 19, malignant.
  • The final diagnosis was determined by pathology (n = 67), PET/CT follow-up (n = 58), correlative imaging (n = 59), clinical correlation (n = 32), or typical benign pattern on PET/CT (n = 13).
  • RESULTS: The causes for benign uptake of FDG were inflammatory processes (n = 154, 73.3%), benign tumors (n = 23, 11%), hematoma or seroma (n = 17, 8.1%), fracture (n = 7, 3.3%), fat necrosis (n = 3, 1.4%), and others (n = 6, 2.9%).
  • For lesions with moderate or marked uptake of FDG (n = 117, 55.7%), a benign diagnosis could have been suggested on either PET or CT (e.g., a "hot" osteophyte) in 33 lesions (28.2%), on CT alone (e.g., peritoneal fat necrosis) in 38 lesions (32.5%), on PET alone (e.g., sialadenitis) in 10 lesions (8.5%), or by clinical correlation (e.g., dental abscess) in four lesions (3.4%).
  • A benign diagnosis could not be established without histology (e.g., colonic polyp) in 32 lesions (27.4%).
  • The performance of PET/CT was superior to that of PET alone in characterizing lesions as benign (p < 0.001).
  • CONCLUSION: Benign lesions with increased FDG uptake are found in more than 25% of the PET/CT studies performed in patients with proven or suspected malignancy, with inflammation being the most common cause.

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  • (PMID = 17954662.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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20. Boyce S, Khor YP: A colonic submucosal lipoma presenting with recurrent intestinal obstruction attacks. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A colonic submucosal lipoma presenting with recurrent intestinal obstruction attacks.
  • Colonic submucosal lipomas are rare benign tumours of the colon, which may be discovered incidentally at colonoscopy, through imaging such as CT or at autopsy.
  • The patient presented 1 year later with intussusception and obstruction resulting from this polyp and required urgent surgery.
  • As complications can ensue, guidelines should be developed to advise on the management of such polyps in order to prevent consequent complications.

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  • [Cites] AJR Am J Roentgenol. 1979 Oct;133(4):743-5 [114027.001]
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  • (PMID = 21686420.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028313
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21. Nowicki MJ, Bishop PR, Subramony C, Wyatt-Ashmead J, May W, Crawford M: Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion. J Pediatr Gastroenterol Nutr; 2005 Nov;41(5):600-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion.
  • Colonic polyps are common both in adults and children; however, the malignant potential varies according to the type of polyp.
  • Most childhood polyps are solitary juvenile polyps, which have negligible malignant potential.
  • Chicken-skin mucosa (CSM) is an endoscopic finding initially described associated with adenomatous polyps and adenocarcinoma, suggesting a preneoplastic lesion.
  • Subsequently, CSM was described in association with juvenile polyps, suggesting that this mucosal finding is not a precursor to dysplasia.
  • To determine whether CSM represents a preneoplastic lesion, we studied endoscopic colonic mucosal biopsies for markers of cell replication (Ki-67) and malignant transformation (p53) in mucosal biopsies of CSM, normal colonic tissue, tubular adenomas, and adenocarcinomas.
  • The degree of Ki-67-positive staining cells was similar for CSM and normal colonic tissue, whereas there was significantly increased staining for both tubular adenomas and adenocarcinomas.
  • There was no evidence of p53 staining in CSM and normal colonic mucosa, whereas there was varying degrees of staining in tubular adenomas and adenocarcinomas.
  • The association of CSM with benign juvenile polyps and the absence of histologic markers for increased replication and malignant transformation support the notion that this endoscopic finding is not preneoplastic.
  • Rather, CSM arises in proximity to polyps of all histologic types because of local mucosal damage.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Intestinal Mucosa / pathology. Ki-67 Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / analysis. Biopsy. Child. Child, Preschool. Colon / pathology. Colonoscopy. Female. Humans. Immunohistochemistry. Male. Prospective Studies

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  • (PMID = 16254516.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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22. Lazaraki G, Tragiannidis D, Xirou P, Nakos A, Pilpilidis I, Katsos I: Endoscopic resection of giant lipoma mimicking colonic neoplasm initially presenting with massive haemorrhage: a case report. Cases J; 2009;2:6462

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of giant lipoma mimicking colonic neoplasm initially presenting with massive haemorrhage: a case report.
  • Lipomas of the colon are benign tumors that rarely occur.
  • During colonoscopy a giant polyp of over 50 mm in its bigger diameter, with a thick stalk of 2 cm, located in the transverse colon, was revealed.
  • In this report discussion over endoscopic resection of colonic lipomas mimicking neoplasms is also performed.

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  • (PMID = 20181161.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827102
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23. Poppers DM, Haber GB: Endoscopic mucosal resection of colonic lesions: current applications and future prospects. Med Clin North Am; 2008 May;92(3):687-705, x
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  • [Title] Endoscopic mucosal resection of colonic lesions: current applications and future prospects.
  • The introduction of submucosal fluid injection has remarkably extended the range of endoscopically resectable polyps.
  • The limiting factor for endoscopic resection is not polyp size, but polyp depth.
  • The success of are section ultimately depends on pathologic confirmation of a benign nature of this lesion or of a cancer limited to the mucosa.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / methods. Intestinal Mucosa / surgery
  • [MeSH-minor] Colonic Neoplasms / surgery. Humans

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  • (PMID = 18387382.001).
  • [ISSN] 0025-7125
  • [Journal-full-title] The Medical clinics of North America
  • [ISO-abbreviation] Med. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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24. Delaney CP, Champagne BJ, Marks JM, Sanuk L, Ermlich B, Chak A: Tissue apposition system: new technology to minimize surgery for endoscopically unresectable colonic polyps. Surg Endosc; 2010 Dec;24(12):3113-8
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  • [Title] Tissue apposition system: new technology to minimize surgery for endoscopically unresectable colonic polyps.
  • OBJECTIVE: This is the first clinical series using the Tissue Apposition System (TAS) device in a feasibility study of polypectomy as an alternative to laparoscopic colectomy (LC) for endoscopically unresectable polyps.
  • METHODS: After institutional review board approval, patients with endoscopically unresectable polyps who would otherwise require LC were enrolled.
  • The polyp site was visualized by colonoscopy and resected with laparoscopic assistance, using endoscopic mucosal resection (EMR) or submucosal dissection.
  • After confirming benign disease by frozen section, the polypectomy site was closed by TAS under laparoscopic observation to avoid injury to surrounding structures.
  • Polyps were from 20 to 50 (mean, 30) mm in diameter; six were in the right colon, and three were on the mesenteric border of the bowel.
  • All final pathology was benign.
  • Two TAS procedures required conversion to LC (one unresectable polyp and one device failure).
  • Follow-up colonoscopy revealed healing without polyp recurrence in any case.
  • One patient (initial 5-cm sigmoid polyp) developed a very mild clinically asymptomatic stricture in the sigmoid colon.
  • CONCLUSIONS: This initial human experience demonstrates that TAS can be used safely in the colon under laparoscopic control.
  • TAS permits safe closure of defects after endoscopic polypectomy of selected and otherwise unresectable polyps.
  • [MeSH-major] Colonic Polyps / surgery. Laparoscopy. Suture Techniques

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  • (PMID = 20490565.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • Mean polyp maximum dimension was 8.5 mm (range, 6-12 mm).
  • The majority of each polyp was nonmalignant SSA.
  • All 8 cases had an abrupt transition from benign to high-grade in situ or invasive malignancy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Aged. Aged, 80 and over. Carrier Proteins / analysis. Cell Transformation, Neoplastic / pathology. Colonic Polyps / pathology. Epithelium / pathology. Humans. Middle Aged. Nuclear Proteins / analysis

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  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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26. Galamb O, Sipos F, Solymosi N, Spisák S, Krenács T, Tóth K, Tulassay Z, Molnár B: Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. Cancer Epidemiol Biomarkers Prev; 2008 Oct;17(10):2835-45
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results.
  • PURPOSE: Gene expression profile (GEP)-based classification of colonic diseases is a new method for diagnostic purposes.
  • EXPERIMENTAL DESIGN: Total RNA was extracted, amplified, and biotinylated from frozen colonic biopsies of patients with colorectal cancer (n=22), adenoma (n=20), hyperplastic polyp (n=11), inflammatory bowel disease (n=21), and healthy normal controls (n=11), as well as peripheral blood samples of 19 colorectal cancer and 11 healthy patients.
  • RESULTS: Adenoma samples could be distinguished from hyperplastic polyps by the expression levels of nine genes including ATP-binding cassette family A, member 8, insulin-like growth factor 1 and glucagon (sensitivity, 100%; specificity, 90.91%).
  • [MeSH-minor] Adenoma / blood. Adenoma / genetics. Adenoma / pathology. Biomarkers, Tumor / analysis. Biopsy. Case-Control Studies. Chi-Square Distribution. Colonic Polyps / blood. Colonic Polyps / genetics. Colonic Polyps / pathology. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Inflammatory Bowel Diseases / blood. Inflammatory Bowel Diseases / pathology. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction

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  • (PMID = 18843029.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
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27. Katsinelos P, Chatzimavroudis G, Zavos C, Pilpilidis I, Lazaraki G, Papaziogas B, Paroutoglou G, Kountouras J, Paikos D: Cecal lipoma with pseudomalignant features: a case report and review of the literature. World J Gastroenterol; 2007 May 7;13(17):2510-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonic lipoma is a well-documented benign neoplasia, endoscopically appearing as a smooth round yellowish polyp with a thick stalk or broad-based attachment.
  • Based on the colonoscopy findings, right hemicolectomy was laparoscopically performed for a presumptive diagnosis of a cecal adenocarcinoma, but histological examination revealed a colonic lipoma with overlying mucosal ulceration.
  • [MeSH-major] Cecum / pathology. Colonic Neoplasms / pathology. Lipoma / pathology

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  • (PMID = 17552037.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 49
  • [Other-IDs] NLM/ PMC4146772
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28. Bezsilla J, Bende S, Varga L, Botos A, Liptay-Wagner P, Sikorszki L, Sümegi J, Nagy G: [Laparoscopic colon operations for endoscopically unremovable polyps and tumors]. Magy Seb; 2005 Oct;58(5):305-10
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laparoscopic colon operations for endoscopically unremovable polyps and tumors].
  • Minimally invasive surgery of benign lesions is widely accepted and can be performed with good results even during the learning curve.
  • After gaining adequate expertise one can remove polyps which can not be treated with a colonoscope and early colonic carcinomas.
  • We performed 16 laparoscopic resections for colon polyps and early carcinomas between December 2002 and March 2005.
  • On one occasion a benign polyp was removed through mini laparotomy after colotomy; 13 resections and 2 subtotal colectomies were performed.
  • [MeSH-major] Colectomy / methods. Colonic Neoplasms / surgery. Colonic Polyps / surgery. Laparoscopy

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  • (PMID = 16496772.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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29. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the colon--Abrikossoff's tumor].
  • [Transliterated title] Granularcelletumor i colon--Abrikossoffs tumor.
  • A 50-year-old woman had a right hemicoletomy due to a large sessile polyp in the ascending colon, inappropriate for polypectomy.
  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • To our knowledge, this is the first reported case of synchronic adenoma and GCT in the colon.
  • To date there is no evidence of any association or disposing factors between GCT in the colon and colonic adenomas or malignancy.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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30. Fox VL, Perros S, Jiang H, Goldsmith JD: Juvenile polyps: recurrence in patients with multiple and solitary polyps. Clin Gastroenterol Hepatol; 2010 Sep;8(9):795-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile polyps: recurrence in patients with multiple and solitary polyps.
  • BACKGROUND & AIMS: Juvenile polyps are benign hamartomas with neoplastic potential that are the most frequent gastrointestinal polyp of childhood.
  • Most information about juvenile polyps in childhood comes from small published series that lack detailed outcome data.
  • We sought to identify a large cohort of children with one or more polyps and analyze clinical characteristics, including polyp recurrence, which might contribute to the development of management guidelines.
  • METHODS: A retrospective chart review study of patients with juvenile polyps of the colon was performed.
  • Cases were identified by searching a single hospital pathology database from 1990 to 2009 for the diagnosis of juvenile polyps.
  • RESULTS: A total of 257 children (median age, 5.6 y; 61.5% male) with juvenile polyps were identified.
  • Among 192 patients who underwent complete colonoscopy at initial diagnosis, 117 (60.9%) had a single polyp, 75 (39.1%) had multiple polyps, 8 (4.2%) had polyps restricted to the right colon, and a total of 1653 polyps were found during 350 colonoscopy examinations.
  • Polyps recurred in 21 of 47 (44.7%) patients after initial eradication, including 3 (16.7%) of 18 presenting with a single polyp.
  • Neoplasia was found in 10 of 257 (3.9%) patients (right colon in 7 patients).
  • Germline DNA abnormalities in mothers against decapentaplegic Drosophila (SMAD4), bone morphogenetic protein receptor 1A (BMPR1A), and phosphatase and tensin homolog (PTEN) were detected in 10 of 23 (43.5%) patients with multiple polyps.
  • CONCLUSIONS: Recurrent polyp formation is common in children with juvenile polyps and occurs in patients with multiple and solitary polyps.
  • Standardized protocols for detecting polyp recurrence, associated gene mutations, and neoplasia should be developed for children with juvenile polyps.
  • [MeSH-major] Colonic Neoplasms / epidemiology. Intestinal Polyposis / epidemiology

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  • [Copyright] Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20580940.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Singh S, Thakur M: Pneumoscrotum after colonoscopy. Can J Gastroenterol; 2008 Apr;22(4):411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present paper describes the case of an 81-year-old man with benign pneumoscrotum that formed after polypectomy at the site of a previous rectal polyp.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / adverse effects. Genital Diseases, Male / etiology. Intestinal Perforation / etiology. Scrotum. Subcutaneous Emphysema / etiology

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  • (PMID = 18414718.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
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32. Øgreid D, Hamre E: Stool DNA analysis detects premorphological colorectal neoplasia: a case report. Eur J Gastroenterol Hepatol; 2007 Aug;19(8):725-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We found, in an asymptomatic patient with familial occurrence of malignancy, that mutations in the oncogene Kras could be detected in stool 18 months before a premalignant polyp was detected and removed endoscopically.
  • Colorectal cancers usually develop from benign adenomas in a lengthy period of 5-10 years.
  • This case report shows that the use of genetic markers in stool testing has the potential to detect colon cancer in its very early stages when treatment is simple and often successful.
  • [MeSH-minor] Colonic Polyps / diagnosis. Genetic Markers. Humans. Male. Middle Aged. Mutation. Neoplastic Syndromes, Hereditary / diagnosis. Proto-Oncogene Proteins / genetics. ras Proteins / genetics

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  • (PMID = 17625445.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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33. Rüschoff J, Aust D, Hartmann A: [Colorectal serrated adenoma: diagnostic criteria and clinical implications]. Verh Dtsch Ges Pathol; 2007;91:119-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • More than 40 years ago Morson (1962) coined the paradigm that adenomas are the main precursors of colorectal carcinoma (CRC) whereas hyperplastic polyps are "non-neoplastic" lesions without cancer risk.
  • It's the merit of Jass (1999) to demonstrate that carcinogenesis in sporadic MSI-positive CRC is associated with serrated polyps.
  • These polyps form the hallmark of a third "serrated (neoplasia) pathway" exhibiting a hyperplastic polyp-like morphology characterized by serrated crypt epithelium.
  • In contrast to adenomatous polyps with readily apparent cytological atypia (dysplasia) the feature of dysplasia in serrated polyps is architectural distortion.
  • Today four categories of serrated lesions can be delineated: (i) the most frequent classic hyperplastic polyp (HP, 80-90%), followed by (ii) sessile serrated adenoma (SSA, 15-20%) and (iii) by the rare traditional serrated adenoma (TSA, < 1%).
  • Whereas HPP are benign, SSA are probably slowly progressing lesions and TSA as well as SSA with APC-type adenomatous atypias (iv. mixed SSA) indicate increased cancer risk.
  • Molecularly serrated polyps seem to share a defect in apoptosis caused by either K-ras or BRAF gene mutation leading to CpG island methylation (CIMP) affecting MLHI (--> MSI type CRC) or non-MMR oncogenes (--> MSI-L or MSS type serrated CRC, Mäkinen 2007).
  • [MeSH-minor] Colonic Polyps / pathology. Diagnosis, Differential. Genes, APC. Humans. Hyperplasia / pathology. Mutation


34. White V, Shaw AG, Tierney GM, Lund JN, Semeraro D: Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report. J Med Case Rep; 2008;2:130

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report.
  • Here we report a rare case of metaplastic ossification within a benign ulcerating adenoma and review the literature concerning the aetiology.
  • CASE PRESENTATION: A 63-year-old woman, who presented with a history of melaena, was found at colonoscopy to have a pedunculated ulcerating polyp.
  • Histological examination demonstrated multiple areas of osseous metaplasia within the polyp stroma.
  • CONCLUSION: Heterotopic ossification in colonic adenomas is a particularly rare phenomenon, with the majority of cases occurring within malignant lesions.

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  • (PMID = 18445248.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2386133
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35. Gross SA, Wallace MB: Hold on Picasso, narrow band imaging is here. Am J Gastroenterol; 2006 Dec;101(12):2717-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The goal of colonoscopy is to identify and remove premalignant and malignant polyps.
  • During colonoscopy it is not feasible to differentiate with certainty if a polyp is benign or premalignant, resulting in removal of all polyps via polypectomy.
  • In attempts to overcome this clinical dilemma, techniques such as chromendoscopy have been developed to aid in improving the accuracy of identifying precancerous polyps.
  • Chromendoscopy helps detect suspicious polyps using a dye spraying technique, but it is time consuming and causes collateral distortion of the adjacent mucosal field.
  • NBI and other similar technologies will likely provide an electronic, easier alternative to chromoendoscopy to aid the endoscopist in differentiation among benign, premalignant, and malignant mucosal patterns.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / methods

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  • [CommentOn] Am J Gastroenterol. 2006 Dec;101(12):2711-6 [17227517.001]
  • (PMID = 17227518.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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36. Willis S, Schumpelick V: [Open colon surgery]. Chirurg; 2005 Nov;76(11):1073-81
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Open colon surgery].
  • Open resection of the colon is one of the most frequent abdominal operations, which clearly indicates the great importance of colon carcinomas.
  • In this respect, the techniques employed are strictly standardized: right hemicolectomy for right colon carcinoma, transverse resection for right colon carcinoma, left hemicolectomy for descendent colon carcinoma, and sigmoid resection for sigmoid carcinoma.
  • In case of benign underlying disease, the operational method depends largely on the extent to which the intestine is affected and can include anything from simple colotomy and polyp removal to colectomy for toxic megacolon.
  • Elective colon surgery is usually primary, but in emergencies a protective stoma might be necessary.
  • Standardized indication and operational techniques enable low perioperative mortality and complication rates that make open colon resection usually un-problematic even in very old patients.
  • [MeSH-minor] Anastomosis, Surgical / methods. Colon / pathology. Colonic Polyps / mortality. Colonic Polyps / pathology. Colonic Polyps / surgery. Humans. Neoplasm Invasiveness / pathology. Neoplasm Staging. Postoperative Complications / mortality. Surgical Staplers. Surgical Wound Dehiscence / mortality. Survival Analysis. Suture Techniques

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  • (PMID = 16240155.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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37. Suehiro Y, Hinoda Y: Genetic and epigenetic changes in aberrant crypt foci and serrated polyps. Cancer Sci; 2008 Jun;99(6):1071-6
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  • [Title] Genetic and epigenetic changes in aberrant crypt foci and serrated polyps.
  • Serrated adenoma (SA) is a polyp with serrated architecture and dysplasia, and can be subclassified as traditional SA or sessile SA.
  • Serrated polyps include hyperplastic polyps (HP), SA, and admixed hyperplastic-adenomatous polyps and are considered a morphological continuum encompassing heteroplastic ACF, HP, admixed hyperplastic-adenomatous polyps, and SA.
  • Sporadic HP are usually present in the left colon, are small, and are considered benign.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. Epigenesis, Genetic

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  • (PMID = 18384435.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 85
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38. Benarroch-Gampel J, Riall TS: Extrapancreatic malignancies and intraductal papillary mucinous neoplasms of the pancreas. World J Gastrointest Surg; 2010 Oct 27;2(10):363-7

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  • The gastrointestinal tract is most commonly involved in secondary malignancies, with benign colon polyps and colon cancer commonly seen in western countries and gastric cancer commonly seen in Asian countries.
  • Other extrapancreatic malignancies associated with IPMNs include benign and malignant esophageal neoplasms, gastrointestinal stromal tumors, carcinoid tumors, hepatobiliary cancers, breast cancers, prostate cancers, and lung cancers.

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  • (PMID = 21160845.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999205
  • [Keywords] NOTNLM ; Intraductal papillary mucinous neoplasm / Invasive / Malignant potential / Non-invasive / Secondary malignancy
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39. Buchner AM, Shahid MW, Heckman MG, Krishna M, Ghabril M, Hasan M, Crook JE, Gomez V, Raimondo M, Woodward T, Wolfsen HC, Wallace MB: Comparison of probe-based confocal laser endomicroscopy with virtual chromoendoscopy for classification of colon polyps. Gastroenterology; 2010 Mar;138(3):834-42
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  • [Title] Comparison of probe-based confocal laser endomicroscopy with virtual chromoendoscopy for classification of colon polyps.
  • Our primary aim was to compare sensitivity and specificity of pCLE to virtual chromoendoscopy for classification of colorectal polyps using histopathology as a gold standard.
  • A secondary aim was to compare sensitivity and specificity of pCLE to virtual chromoendoscopy using a modified gold standard that assumed that all polyps >/=10 mm had malignant potential and were considered neoplastic or high risk.
  • Each polyp was diagnosed as benign or neoplastic based on confocal features according to modified Mainz criteria.
  • RESULTS: A total of 119 polyps (81 neoplastic, 38 hyperplastic) from 75 patients was assessed.
  • CONCLUSIONS: Confocal endomicroscopy demonstrated higher sensitivity with similar specificity in classification of colorectal polyps.
  • These new methods may replace the need for ex vivo histological confirmation of small polyps, but further studies are warranted.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Colon / pathology. Colonic Neoplasms / diagnosis. Colonic Polyps / diagnosis. Colonoscopes. Colonoscopy / methods. Microscopy, Confocal / instrumentation. Molecular Imaging / instrumentation. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19909747.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00874263
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Wang LC, Lee HC, Yeung CY, Chan WT, Jiang CB: Gastrointestinal polyps in children. Pediatr Neonatol; 2009 Oct;50(5):196-201
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  • [Title] Gastrointestinal polyps in children.
  • BACKGROUND: Gastrointestinal polyps are common in children.
  • The purpose of this study was to review the clinical manifestations, diagnostic procedures, endoscopic findings, management, pathology, and recurrence of gastrointestinal polyps in children at Mackay Memorial Hospital.
  • METHODS: We retrospectively reviewed the charts of 50 children with a diagnosis of gastrointestinal polyps managed at Mackay Memorial Hospital between January 1984 and April 2007.
  • Demographic data; clinical features; polyp size, number and location; endoscopic findings; management; pathology; and information on recurrences were extracted from the clinical records.
  • RESULTS: The distribution of polyps in the 50 patients included gastric (4 patients), duodenal (2), ileocecal (4) and colorectal polyps (40).
  • All patients with gastric polyps presented with vomiting, and three of the four patients with ileocecal polyps presented with intussusception.
  • The mean age of the 40 patients with colorectal polyps was 6.8 years.
  • The majority of those polyps were in the rectosigmoid colon; 36 patients presented with hematochezia.
  • Solitary polyps were identified in 33 patients and multiple polyps were identified in seven patients.
  • Most of the colorectal polyps were less than 2cm in diameter.
  • Histologically, the most frequent type was juvenile polyp.
  • CONCLUSION: Gastrointestinal polyps in children are usually benign.
  • Pediatricians treating a child with a gastrointestinal polyp should pay attention to the immediate complications of the polyps, such as intussusception or bleeding, the extraintestinal manifestations and long-term risk for malignancy.
  • [MeSH-major] Intestinal Polyps / complications. Polyps / complications. Stomach Diseases / complications
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Colonic Polyps / complications. Colonic Polyps / diagnosis. Colonic Polyps / therapy. Female. Humans. Infant. Male. Retrospective Studies

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  • (PMID = 19856862.001).
  • [ISSN] 1875-9572
  • [Journal-full-title] Pediatrics and neonatology
  • [ISO-abbreviation] Pediatr Neonatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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41. Seo GJ, Sohn DK, Han KS, Hong CW, Kim BC, Park JW, Choi HS, Chang HJ, Oh JH: Recurrence after endoscopic piecemeal mucosal resection for large sessile colorectal polyps. World J Gastroenterol; 2010 Jun 14;16(22):2806-11
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  • [Title] Recurrence after endoscopic piecemeal mucosal resection for large sessile colorectal polyps.
  • AIM: To evaluate the safety and outcomes of endoscopic piecemeal mucosal resection (EPMR) for large sessile colorectal polyps.
  • METHODS: The patients enrolled in this study were 47 patients with 50 large sessile polyps (diameter, 2 cm or greater) who underwent EPMR using a submucosal saline injection technique between December 2002 and October 2005.
  • All medical records, including characteristics of the patients and polyps, complications, and recurrences, were retrospectively reviewed.
  • Mean polyp size was 30.1 mm.
  • Of 50 polyps identified, 34 (68%) were benign and 16 (32%) were malignant.
  • The recurrence rate after EPMR was 3.1% for benign polyps and 33.3% for malignant polyps (P < 0.05).
  • CONCLUSION: EPMR is safe, but should be applied carefully in malignant polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonic Polyps / surgery. Endoscopy, Gastrointestinal / methods. Intestinal Mucosa / pathology. Neoplasm Recurrence, Local / diagnosis

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  • [Cites] Gastrointest Endosc. 2000 Jun;51(6):697-700 [10840302.001]
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  • (PMID = 20533602.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2883138
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42. Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM: Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res; 2005 Feb 1;11(3):1203-9
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  • [Title] Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.
  • Colon cancer is the third leading cause of cancer-related death in the United States, affecting approximately 147,000 people each year.
  • Most colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a stepwise histologic progression sequence that starts from adenomas or hyperplastic polyps/serrated adenomas.
  • Genetic alterations and, more recently, epigenetic alterations have been associated with specific steps in this polyp-adenocarcinoma sequence and likely drive the histologic progression of colon cancer.
  • Consequently, we have assessed in colon adenomas and hyperplastic polyps the methylation status of MGMT, CDKN2A, and MLH1 to determine the timing and frequency of these events in the polyp-carcinoma progression sequence and subsequently to analyze the potential for these methylated genes to be molecular markers for adenomas and hyperplastic polyps.
  • We have found that methylated MGMT, CDKN2A, and MLH1 occur in 49%, 34%, and 7% of adenomas and in 5%, 10%, and 7% of hyperplastic polyps, respectively, and that they are more common in histologically advanced adenomas.
  • Furthermore, analysis of fecal DNA from persons who have undergone colonoscopic exams revealed methylated CDKN2A, MGMT, and MLH1 in fecal DNA from 31%, 48%, and 0% of individuals with adenomas and from 16%, 27%, and 10% of individuals with no detectable polyps, respectively.
  • These results show that aberrant methylated genes can be detected frequently in sporadic colon polyps and that they can be detected in fecal DNA.
  • Notably, improvements in the specificity and sensitivity of the fecal DNA-based assays will be needed to make them clinically useful diagnostic tests for polyps.
  • [MeSH-major] Biomarkers, Tumor / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA Methylation. DNA, Neoplasm / genetics

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  • (PMID = 15709190.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA 95103; United States / NCI NIH HHS / CA / U01 CA 094986
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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43. Amosenko FA, Korchagina EL, Matveeva TI, Vaganov IuE, Vlasov SB, Poltavets NV, Veselov VV, Gar'kavtseva RF, Poliakov AV: [Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]. Genetika; 2010 May;46(5):700-8
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  • [Title] [Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients].
  • To estimate diagnostic value of K-ras mutations during cancer risk group formation, they were studied in the samples of sporadic carcinomas (n = 33) and malignant (n = 13) polyps of large intestine obtained during surgery or polypectomy.
  • Mutation frequency in carcinomas, benign and malignant polyps was 43, 49, and 69%, respectively.
  • The maximum mutation frequency was revealed in polyps of patients over 70 years of age as well as in the adenomas of villous histology and large size ((1 cm).
  • No correlation between the K-ras mutation frequency and the extent of polyp dysplasia was observed.
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Neoplasm / genetics. Genes, ras / genetics. Mutation

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  • (PMID = 20583607.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm
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44. Pasquini P, Baiocchini A, Falasca L, Annibali D, Gimbo G, Pace F, Del Nonno F: Mucosal Schwann cell "Hamartoma": a new entity? World J Gastroenterol; 2009 May 14;15(18):2287-9
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  • Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract.
  • In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts.
  • To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation "mucosal Schwann hamartoma".

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  • (PMID = 19437573.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2682248
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45. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N: Microcarcinoids in large intestinal adenomas. Am J Surg Pathol; 2006 Dec;30(12):1531-6
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  • Unlike other mixed endocrine-glandular colorectal neoplasms, which are generally malignant, their glandular component is histologically benign and their natural history is favorable.
  • We present 4 cases of colonic adenomas containing microcarcinoids, a hitherto undescribed lesion that is either a precursor of composite adenoma-carcinoids or a related but independent entity.
  • The cases, identified among our surgical and consultation files, were endoscopically routine sessile polyps removed from 4 otherwise normal individuals, 3 from the cecum and 1 from the distal colon.
  • The microcarcinoids were 0.5 to 1.5 mm in size and situated within the basal lamina propria, where they interposed between the crypts and muscularis mucosae without disturbing the overall polyp architecture.
  • The glandular component of the polyps was unremarkable in 3 cases, but 1 polyp, in addition to a microcarcinoid, showed a diffuse pattern of mixed adenomatous-endocrine differentiation.
  • The patients' clinical course was benign on the basis of 2 years' median follow-up (range, 6 mo to 10 y).
  • Awareness of microcarcinoids in colonic adenomas should help avert potential diagnostic pitfalls posed by their pleomorphism, basal location, and infiltrative patterns, and may help clarify their natural history and possible relationship to composite glandular-carcinoid tumors.

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  • (PMID = 17122508.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Somani BK, Nicol G, Bhavan R, Swami S, Nabi G, Abacus Research Group: Synchronous resections of intra-abdominal pathologies during radical nephrectomy. A case-linked cohort study evaluation of outcomes. Eur J Surg Oncol; 2009 Aug;35(8):844-51
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  • Fifteen underwent radical nephrectomy and surgical resection of a second intra-abdominal non-urological malignancy: colonic tumour - 8, rectal tumour - 3, oesophageal tumour - 2 and gastric tumour - 2.
  • Fifteen patients underwent radical nephrectomy and surgical resection of a synchronous benign intra-abdominal pathology: gall bladder - 8, spleen - 3, uterine fibroid - 1, abdominal aortic aneurysm - 1, colonic polyp - 1 and suspected tumour infiltration of colon - 1.

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  • (PMID = 18976878.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Szajda SD, Jankowska A, Zwierz K: Carbohydrate markers in colon carcinoma. Dis Markers; 2008;25(4-5):233-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carbohydrate markers in colon carcinoma.
  • Spontaneously mutated multiple oncogenes and/or tumor suppressor genes in colon epithelial cell and its progeny, may cause proliferation out of control and create benign colon neoplasm (colon polyp).
  • If additional mutations involve genes responsible for cell adhesion and movement, aberrant epithelial cells may become malignant (colon cancer) and invade surrounding and remote tissues, creating secondary tumors called metastases.
  • To laboratory detection and monitoring of colon cancer are used tumor markers.
  • Glycoconjugate markers for colon cancer include aberrant: mucins covering the surface of the colon epithelial cells, cadherins, selectins and Ig-like adhesion molecules mediating cell-cell adhesion, integrins and integral membrane proteoglycans responsible for adhesion of colon epithelial cells to extracellular matrix, glycoconjugate components of ECM, as well as lysosomal membrane glycoproteins and exoglycosidases.
  • Detection of colon cancer at early non malignant stage is crucial in its prevention and eradication.
  • As colon cancer is the effect of accumulation many somatic mutations in oncogens, supressors, mismatch repair genes and many genes responsible for posttranslational modifications of proteins, multidirectional approach should be applied for its detection.
  • A glycobiological approach to diagnosis and treatment of colorectal cancer should be directed to detection changes in glycosylation accompanying every step of colon cancer progression, and correlation between changes in glycosylation and tumor progression.
  • [MeSH-major] Carbohydrates / chemistry. Carcinoma / metabolism. Colonic Neoplasms / metabolism

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  • (PMID = 19126967.001).
  • [ISSN] 0278-0240
  • [Journal-full-title] Disease markers
  • [ISO-abbreviation] Dis. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cadherins; 0 / Carbohydrates; 0 / Glycoproteins; 0 / Mucins; 0 / Polysaccharides
  • [Number-of-references] 79
  • [Other-IDs] NLM/ PMC3827819
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48. Grady WM: Epigenetic events in the colorectum and in colon cancer. Biochem Soc Trans; 2005 Aug;33(Pt 4):684-8
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  • [Title] Epigenetic events in the colorectum and in colon cancer.
  • Colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a stepwise histological progression sequence, proceeding from either adenomas or hyperplastic polyps/serrated adenomas.
  • Genetic alterations have been associated with specific steps in this polyp-adenocarcinoma sequence and are believed to drive the histological progression of colon cancer.
  • Recently, epigenetic alterations, which include CGI (CpG island) DNA methylation, have been shown to occur in colon polyps and colon cancer.
  • The aberrant methylation of genes appears to co-operate with the genetic alterations to drive the initiation and progression of colon polyps to colon cancer.
  • These hypermethylated genes are not only probable pathogenic events affecting colon-cancer formation, but also neoplasm-specific molecular events that may be useful as molecular markers for colon tumours.
  • Furthermore, aberrant DNA methylation of tumour-suppressor genes may occur secondary to a genetic predisposition or to a field-cancerization effect in the colon and may be useful as molecular markers for the risk of developing colon cancer.
  • [MeSH-major] Colon / physiology. Colonic Neoplasms / genetics. Epigenesis, Genetic / genetics. Rectum / physiology
  • [MeSH-minor] Colonic Polyps / genetics. Gene Silencing. Genetic Markers. Humans

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  • (PMID = 16042574.001).
  • [ISSN] 0300-5127
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Number-of-references] 33
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49. Stoler DL, Nowak NJ, Matsui S, Wiseman SM, Chen N, Dutt SS, Bartos JD, Loree TR, Rigual NR, Hicks WL Jr, Sait SN, Anderson GR: Comparative genomic instabilities of thyroid and colon cancers. Arch Otolaryngol Head Neck Surg; 2007 May;133(5):457-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative genomic instabilities of thyroid and colon cancers.
  • OBJECTIVES: To assess the forms and extent of genomic instability in thyroid cancers and colorectal neoplasms and to determine if such measurements could explain the generally excellent prognosis of thyroid malignant neoplasms compared with colon carcinoma.
  • RESULTS: The genomic instability index of 32 thyroid carcinomas, 59 colon carcinomas, and 11 colon polyps was determined by ISSR-PCR; no difference was seen among the 3 groups by this method.
  • Fractional allelic loss rates were comparable in thyroid cancers and colon polyps and lower than FAL rates in colorectal cancers.
  • CONCLUSIONS: Genomic alterations in papillary thyroid carcinoma, such as in benign colon polyps, are principally smaller events detected by ISSR-PCR.
  • [MeSH-major] Carcinoma / genetics. Carcinoma, Papillary / genetics. Colonic Neoplasms / genetics. Genomic Instability / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17515504.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA16056; United States / NCI NIH HHS / CA / R01 CA 74127
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. Leman ES, Schoen RE, Weissfeld JL, Cannon GW, Sokoll LJ, Chan DW, Getzenberg RH: Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers. Cancer Res; 2007 Jun 15;67(12):5600-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers.
  • Colon cancer-specific antigen (CCSA)-3 and CCSA-4 are novel colon cancer markers identified by focused proteomic analysis of nuclear structural proteins.
  • Serum samples from 107 subjects undergoing colonoscopy, 28 subjects with colorectal cancer, and 125 subjects with benign disease or other types of cancer were evaluated.
  • Individuals who underwent colonoscopy were classified into mutually exclusive categories, including normal colon, hyperplastic polyp, nonadvanced adenoma, and advanced adenoma.
  • The specificity in individuals with normal, hyperplastic polyps, or nonadvanced adenomas was 82.0% (95% CI, 72.4-89.4%) and 91.0% (95% CI, 83.0-96.0%) for CCSA-3 and CCSA-4, respectively.
  • [MeSH-major] Adenocarcinoma / blood. Adenoma / blood. Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Colonic Neoplasms / blood

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  • [RetractionIn] Schoen RE, Weissfeld JL, Sokoll LJ, Chan DW, Cannon GW, Getzenberg RH. Cancer Res. 2013 Jan 15;73(2):1034 [23271721.001]
  • (PMID = 17575123.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01 CA084968
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / colon-specific antigen
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51. Fenech DS, Takahashi T, Liu M, Spencer L, Swallow CJ, Cohen Z, Macrae HM, McLeod RS: Function and quality of life after transanal excision of rectal polyps and cancers. Dis Colon Rectum; 2007 May;50(5):598-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Function and quality of life after transanal excision of rectal polyps and cancers.
  • PURPOSE: The purpose of this study was to determine the functional outcomes and health-related quality of life of patients after transanal excision of rectal cancers or polyps and to assess the relationship between functional outcomes and health-related quality of life.
  • METHODS: All patients having a transanal excision at the Mount Sinai Hospital from 1989 to 2002 were included if the indication for surgery was a benign or malignant neoplasm.
  • Of these, 29 had villous adenomas, 2 had carcinoids, and 1 had a hyperplastic polyp.
  • [MeSH-major] Colonic Polyps / surgery. Fecal Incontinence / physiopathology. Quality of Life. Recovery of Function. Rectal Neoplasms / surgery

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  • (PMID = 17309002.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Kim JH, Lim YJ, Kim YH, Sung IK, Shim SG, Oh SO, Park SS, Yang S, Son HJ, Rhee PL, Kim JJ, Rhee JC, Choi YH: Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev; 2007 Aug;16(8):1543-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We classified a total of 2,531 subjects into the adenoma group (n = 731) and the control group (n = 1,800), including normal colonoscopic finding, nonpolyp benign lesions, or histologically confirmed hyperplastic polyp.
  • An increased risk for metabolic syndrome was more evident for proximal than distal colon, for multiple (>/=3), and for advanced adenoma in the adenoma group.
  • [MeSH-major] Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Metabolic Syndrome X / epidemiology. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adenoma, Villous / epidemiology. Age Factors. Alcohol Drinking / epidemiology. Body Weights and Measures. Colonic Polyps / epidemiology. Colonoscopy. Diabetes Mellitus / epidemiology. Female. Humans. Hyperlipidemias / epidemiology. Hyperplasia. Hypertension / epidemiology. Korea / epidemiology. Male. Mass Screening. Middle Aged. Obesity / epidemiology. Precancerous Conditions / epidemiology. Risk Factors. Sex Factors. Smoking / epidemiology

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  • (PMID = 17684126.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Latchford AR, Neale KF, Spigelman AD, Phillips RK, Clark SK: Features of duodenal cancer in patients with familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2009 Jun;7(6):659-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two were diagnosed at surveillance and 3 were diagnosed during surgery performed for endoscopic features of advanced benign disease.
  • Duodenal cancers were associated with a significantly lower mean colonic polyp count than ampullary cancers (496 +/- 282 vs 1322 +/- 735; P = .025); there appeared to be familial clustering of this cancer.

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  • (PMID = 19281862.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Pickhardt PJ, Kim DH, Taylor AJ, Gopal DV, Weber SM, Heise CP: Extracolonic tumors of the gastrointestinal tract detected incidentally at screening CT colonography. Dis Colon Rectum; 2007 Jan;50(1):56-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Following cathartic preparation and colonic distention, supine and prone multidetector CT scans were obtained with thin-collimation low-dose technique without intravenous contrast.
  • Final diagnoses were benign in all cases and included lipoma (n = 3), small-bowel hamartoma (n = 2), appendiceal mucinous cystadenoma (n = 2), gastric leiomyoma (n = 1), small-bowel lymphangioma (n = 1), and gastric fundic gland polyp (n = 1).
  • CONCLUSIONS: Incidental extracolonic tumors of the gastrointestinal tract detected at screening CT colonography were all asymptomatic and benign but often prompted more invasive workup.

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  • (PMID = 17115333.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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