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1. Vajaranant TS, Mafee MF, Kapur R, Rapoport M, Edward DP: Medulloepithelioma of the ciliary body and optic nerve: clinicopathologic, CT, and MR imaging features. Neuroimaging Clin N Am; 2005 Feb;15(1):69-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medulloepithelioma of the ciliary body and optic nerve: clinicopathologic, CT, and MR imaging features.
  • The definitive diagnosis of medulloepitheliomas of the ciliary body and optic nerve is made by histopathologic examination.
  • Familiarity with rare tumors aids clinicians in accurately diagnosing this rare neoplasm.
  • CT and MR imaging findings can be helpful, especially if the mass is confined in an area of the ciliary body without involvement of the retina.
  • Clinical diagnosis of medulloepitheliomas of the optic nerve and central nervous system (CNS) is more challenging.
  • The diagnosis is often made by histopathologic examination.
  • [MeSH-major] Ciliary Body. Neuroectodermal Tumors, Primitive / diagnosis. Optic Nerve Neoplasms / diagnosis. Uveal Neoplasms / diagnosis

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  • (PMID = 15927861.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY01792
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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2. Shields JA, Shields CL, Eagle RC Jr, Friedman ES, Wheatley HM: Age-related hyperplasia of the nonpigmented ciliary body epithelium (Fuchs adenoma) simulating a ciliary body malignant neoplasm. Arch Ophthalmol; 2009 Sep;127(9):1224-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age-related hyperplasia of the nonpigmented ciliary body epithelium (Fuchs adenoma) simulating a ciliary body malignant neoplasm.
  • [MeSH-major] Adenoma / pathology. Ciliary Body / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Aging. Diagnosis, Differential. Epithelium / pathology. Epithelium / surgery. Epithelium / ultrasonography. Female. Humans. Hyperplasia. Microscopy, Acoustic. Middle Aged

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  • (PMID = 19752438.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Stewart JM: Ciliary body edema. Ophthalmology; 2006 Jul;113(7):1247; author reply 1247-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ciliary body edema.
  • [MeSH-major] Ciliary Body / pathology. Edema / etiology. Retinal Detachment / surgery. Scleral Buckling / adverse effects. Uveal Diseases / etiology

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  • [CommentOn] Ophthalmology. 2006 Jan;113(1):36-41 [16290050.001]
  • (PMID = 16815411.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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4. Aptel F, Charrel T, Palazzi X, Chapelon JY, Denis P, Lafon C: Histologic effects of a new device for high-intensity focused ultrasound cyclocoagulation. Invest Ophthalmol Vis Sci; 2010 Oct;51(10):5092-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To evaluate the histologic effects and clinical outcomes of high-intensity focused ultrasound (HIFU) delivered by miniaturized annular transducers for ciliary body coagulation in an animal study.
  • Histologic examination showed segmental-to-annular lesions in the ciliary processes, caused mainly by coagulation necrosis, whereas the sclera and lens appeared undamaged.
  • CONCLUSIONS: Ultrasonic coagulation of the ciliary body with HIFU delivered via a circular miniaturized transducer seemed to be an effective and well-tolerated method of reducing intraocular pressure in an animal study.
  • [MeSH-major] Ciliary Body / pathology. Intraocular Pressure. Ultrasonic Therapy / instrumentation
  • [MeSH-minor] Animals. Ciliary Arteries. Equipment Design. Glaucoma / therapy. Male. Models, Biological. Necrosis. Rabbits. Tonometry, Ocular. Transducers

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  • (PMID = 20484580.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Mura JJ, Pavlin CJ, Condon GP, Belovay GW, Kranemann CF, Ishikawa H, Ahmed II: Ultrasound biomicroscopic analysis of iris-sutured foldable posterior chamber intraocular lenses. Am J Ophthalmol; 2010 Feb;149(2):245-252.e2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • UBM was used to determinate the haptic position in relation to the ciliary sulcus and ciliary body in these eyes.
  • RESULTS: Of the 30 haptics imaged, 16 (53.3%) were positioned in the ciliary sulcus.
  • Nine (30%) haptics were found over the ciliary processes, and 5 (16.7%) were over pars plana.
  • CONCLUSIONS: Iris-sutured PCIOL haptics were found to be in the ciliary sulcus or over the ciliary body with no significant tilt on UBM analysis.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19896636.001).
  • [ISSN] 1879-1891
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins
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6. Kodjikian L, Grange JD, Baldo S, Baillif S, Garweg JG, Rivoire M: Prognostic factors of liver metastases from uveal melanoma. Graefes Arch Clin Exp Ophthalmol; 2005 Oct;243(10):985-93
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  • Factors including patient demographics, characteristics of the uveal tumor, metastasis-free interval, severity of liver metastatic involvement, and treatments of metastases were studied retrospectively regarding their prognostic value, using univariate (Kaplan-Meier method) and multivariate (Cox model) analyses.
  • The median overall survival after diagnosis of liver metastases was 15 months.
  • In this cohort of 63 patients, ten or fewer preoperatively diagnosed metastases and primary uveal melanoma not involving the ciliary body were independently associated with better prognosis.
  • The two independent favorable prognostic factors are fewer than ten metastases at screening and the absence of ciliary body involvement.

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  • (PMID = 15891893.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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7. Sundin OH, Dharmaraj S, Bhutto IA, Hasegawa T, McLeod DS, Merges CA, Silval ED, Maumenee IH, Lutty GA: Developmental basis of nanophthalmos: MFRP Is required for both prenatal ocular growth and postnatal emmetropization. Ophthalmic Genet; 2008 Mar;29(1):1-9
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  • BACKGROUND: Nanophthalmos is a genetic disorder characterized by very small, hyperopic eyes that are without gross structural defects.
  • Recessive nanophthalmos is caused by severe mutations in the MFRP gene, which encodes a Frizzled-related transmembrane protein that is selectively expressed in the retinal pigment epithelium (RPE) and ciliary body.

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  • [CommentIn] Ophthalmic Genet. 2008 Dec;29(4):189 [19005993.001]
  • (PMID = 18363166.001).
  • [ISSN] 1744-5094
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY013610-03; United States / NEI NIH HHS / EY / EY016151-04; United States / NEI NIH HHS / EY / P30 EY001765; United States / NEI NIH HHS / EY / EY016151; United States / NEI NIH HHS / EY / R01 EY016151-04; United States / NEI NIH HHS / EY / R01 EY013610-03; United States / NEI NIH HHS / EY / R01 EY016151; United States / NEI NIH HHS / EY / EY013610; United States / NEI NIH HHS / EY / EY01765; United States / NEI NIH HHS / EY / R01 EY013610
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MFRP protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ NIHMS141632; NLM/ PMC2739627
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8. Viswanathan S, Mukul D, Qureshi S, Ramadwar M, Arora B, Kane SV: Orbital medulloepitheliomas -- with extensive local invasion and metastasis: a series of three cases with review of literature. Int J Pediatr Otorhinolaryngol; 2008 Jul;72(7):971-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraocular medulloepithelioma is a rare embryonal neoplasm which usually presents in childhood as a ciliary body mass.
  • This tumor is usually confined to the orbit and rarely tends to be locally aggressive and metastatic.
  • [MeSH-minor] Adolescent. Adult. Child. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 18499271.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 8
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9. Süveges I: [Intraocular tumours]. Magy Onkol; 2005;49(1):9-13
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  • Intraocular tumours may be benign or malignant.
  • Melanoma malignum may arise from all three areas of the uvea: the iris, the ciliary body and the choroid.
  • The tumour may also present intracranially, therefore CT of the skull should be performed in each case.
  • Histologically the tumour contains malignant neuroepithelial cells, which may form a rosette.
  • Some benign tumours are found by chance on routine eye examinations, others due to subjective and objective symptoms.
  • [MeSH-minor] Humans. Lymphoma / diagnosis. Lymphoma / therapy. Melanoma / diagnosis. Melanoma / therapy. Retinal Neoplasms / diagnosis. Retinal Neoplasms / therapy. Retinoblastoma / diagnosis. Retinoblastoma / therapy

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  • (PMID = 15902327.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 2
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10. Canovas D, Rennie IG, Nichols CE, Sisley K: Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory. Cancer; 2008 Apr 15;112(8):1787-94
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  • BACKGROUND: Uveal melanomas of the choroid and ciliary body are aggressive tumors causing the death of approximately 50% of patients.
  • Tumor location, and the baseline invasion of the melanoma, affected the ability of aqueous and vitreous from different patients to regulate invasive behavior.
  • CONCLUSIONS: The findings suggest that in situ uveal melanoma development reflects an interaction between the tumor and the environment of the eye.
  • Exposure to the aqueous would therefore contribute to the benign nature of iris melanomas, whereas potential interaction with the vitreous appears to promote the aggressive behavior of posterior uveal melanomas.
  • [MeSH-major] Aqueous Humor / physiology. Melanoma / pathology. Uveal Neoplasms / pathology. Vitreous Body / physiopathology
  • [MeSH-minor] Adult. Aged. Anticarcinogenic Agents / pharmacology. Carcinogens / pharmacology. Cell Line, Tumor. Cell Proliferation. Chemotaxis / physiology. Choroid Neoplasms / pathology. Ciliary Body / pathology. Cytokines / drug effects. Female. Follow-Up Studies. Humans. Iris Neoplasms / pathology. Male. Middle Aged. Neoplasm Invasiveness. Tissue Culture Techniques. Tissue Inhibitor of Metalloproteinase-2 / drug effects. Tissue Inhibitor of Metalloproteinase-3 / drug effects. Transforming Growth Factor beta2 / drug effects

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  • (PMID = 18300240.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Cytokines; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transforming Growth Factor beta2; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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11. Sandner D, Pillunat LE, Fischer R: [Adenoma of the pigmented epithelium of the ciliary body]. Klin Monbl Augenheilkd; 2009 Jan;226(1):68-9
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  • [Title] [Adenoma of the pigmented epithelium of the ciliary body].
  • [MeSH-major] Adenoma / diagnosis. Ciliary Body / pathology. Pigment Epithelium of Eye / pathology. Uveal Neoplasms / diagnosis

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  • (PMID = 19173167.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R: CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci; 2006 Dec;47(12):5505-13
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  • [Title] CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion.
  • PURPOSE: In a prior study, a S163R mutation in the complement-1q tumor necrosis factor-related protein 5 (CTRP5/ C1QTNF5) was reported to be associated with early-onset long anterior zonules (LAZ) and late-onset retinal degeneration (L-ORD).
  • The ocular tissues involved in the phenotype are the retinal pigment epithelium (RPE) in the posterior segment and ciliary epithelium (CE) and lens in the anterior segment.
  • RESULTS: A significant level of Ctrp5 expression was detected in the adult mouse in the ciliary body (CB) and RPE, and expression started at a very early stage of embryogenesis.
  • In the ciliary body, CTRP5 was localized to the apical aspects of the CE, the region between the bilayered ciliary epithelial cells.
  • [MeSH-major] Ciliary Body / metabolism. Membrane Proteins / genetics. Pigment Epithelium of Eye / metabolism. Point Mutation

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  • (PMID = 17122142.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY07003; United States / NEI NIH HHS / EY / EY07060; United States / NEI NIH HHS / EY / EY13198; United States / NEI NIH HHS / EY / P30EY13080
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTRP5 protein, mouse; 0 / Membrane Proteins
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13. Mei H, Xing Y, Yang J, Wang A, Xu Y, Heiligenhaus A: Influence of antisense oligonucleotides targeting tumor necrosis factor-alpha on experimental herpetic-induced chorioretinitis of mouse eye. Pathobiology; 2009;76(1):45-50
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  • [Title] Influence of antisense oligonucleotides targeting tumor necrosis factor-alpha on experimental herpetic-induced chorioretinitis of mouse eye.
  • OBJECTIVE: To investigate the effect on the pathological process of topical treatment with antisense oligonucleotides (ASON) targeting tumor necrosis factor-alpha (TNF-alpha) in experimental herpes simplex virus type-1 (HSV-1)-induced chorioretinitis of mouse eye.
  • The number of inflammatory cells in the ASON group was significantly lower than in the PBS group, especially in the choroid, retina and ciliary body.
  • [MeSH-major] Chorioretinitis / drug therapy. Eye Infections, Viral / drug therapy. Oligonucleotides, Antisense / therapeutic use. Tumor Necrosis Factor-alpha / metabolism

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19188750.001).
  • [ISSN] 1423-0291
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Oligonucleotides, Antisense; 0 / Tumor Necrosis Factor-alpha
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14. Fujii N, Kaji Y, Fujii N, Nakamura T, Motoie R, Mori Y, Kinouchi T: Collapse of homochirality of amino acids in proteins from various tissues during aging. Chem Biodivers; 2010 Jun;7(6):1389-97
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  • Here, we discuss the presence of D-beta-Asp-containing proteins in the lens, ciliary body, drusen, and sclera of the eye, skin, cardiac muscle, blood vessels of the lung, chief cells of the stomach, longitudinal and circular muscles of the stomach, and small and large intestines.

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  • (PMID = 20564552.001).
  • [ISSN] 1612-1880
  • [Journal-full-title] Chemistry & biodiversity
  • [ISO-abbreviation] Chem. Biodivers.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Proteins; 4SR0Q8YD1X / D-Aspartic Acid
  • [Number-of-references] 28
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15. Abramson DH, Rollins IS, Lin A, Odell P, Folberg R: Tadalafil-induced subretinal and choroidal hemorrhage in a patient with an unsuspected uveal (choroidal and ciliary body) melanoma. Arch Ophthalmol; 2006 Jul;124(7):1058-60
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  • [Title] Tadalafil-induced subretinal and choroidal hemorrhage in a patient with an unsuspected uveal (choroidal and ciliary body) melanoma.

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  • [ErratumIn] Arch Ophthalmol. 2007 Mar;125(3):438. Dosage error in article text
  • (PMID = 16832036.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbolines; 0 / Phosphodiesterase Inhibitors; 742SXX0ICT / Tadalafil
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16. Miller SN, Colitz CM, Dubielzig RR: Anatomy of the California sea lion globe. Vet Ophthalmol; 2010 Sep;13 Suppl:63-71
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  • A large, wide ciliary cleft with prominent trabeculae and a single continuous pectinate ligament was present.
  • A round lens attached to the ciliary body via direct attachment to ciliary processes and delicate zonular ligaments.
  • There was a circumferential muscle at the base of the ciliary processes.

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  • (PMID = 20840092.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Héon E, Crick RP, Child A, Sarfarazi M: Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum Mol Genet; 2005 Mar 15;14(6):725-33
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  • WDR36 gene expression in lens, iris, sclera, ciliary muscles, ciliary body, trabecular meshwork, retina and optic nerve were established by RT-PCR.


18. Kohno R, Ikeda Y, Yonemitsu Y, Hisatomi T, Yamaguchi M, Miyazaki M, Takeshita H, Ishibashi T, Sueishi K: Sphere formation of ocular epithelial cells in the ciliary body is a reprogramming system for neural differentiation. Brain Res; 2006 Jun 6;1093(1):54-70
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  • [Title] Sphere formation of ocular epithelial cells in the ciliary body is a reprogramming system for neural differentiation.
  • Retinal stem/progenitor properties were also isolated from the ciliary body (CB) of the eye where, as in the CNS, such stem/progenitors also form spheres and have been considered to expand only via expansion by their proliferation even from the single-cell level (called spheres of pigment cells from the ciliary margin: PCM-spheres).
  • [MeSH-major] Cell Differentiation / physiology. Ciliary Body / cytology. Neurons / cytology. Stem Cells / cytology

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  • (PMID = 16697356.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 38966-21-1 / Aphidicolin
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19. Dai YH, Xie LX, Wu XG, Huang YS, Gong HQ, Yin HM: [Experimental study of low molecular weight heparin drug delivery system for prevention of posterior capsular opacification in rabbit eyes]. Zhonghua Yan Ke Za Zhi; 2009 Nov;45(11):1033-8
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  • Neither infiltration of inflammatory cells at the cornea, iris, trabecular meshwork and ciliary body nor retinal degeneration or necrosis was found in any group at 12 weeks.

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  • (PMID = 20137424.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Heparin, Low-Molecular-Weight; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid
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20. Meghpara B, Li X, Nakamura H, Khan A, Bejjani BA, Lin S, Edward DP: Human anterior chamber angle development without cell death or macrophage involvement. Mol Vis; 2008;14:2492-8
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  • Few CD68 positive cells were observed in the iris stroma and the anterior ciliary body between fetal weeks 10 and 18 (F10w and F18w).

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  • [ISSN] 1090-0535
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  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Bauer J, Kilic E, Vaarwater J, Bastian BC, Garbe C, de Klein A: Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma. Br J Cancer; 2009 Sep 1;101(5):813-5
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  • METHODS: GNAQ exon 5 was amplified from 75 ciliary body and choroidal melanoma DNAs and sequenced directly.
  • RESULTS: Of the 75 tumour DNA samples analysed, 40 (53.3%) harboured oncogenic mutations in GNAQ codon 209.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gq-G11 / genetics. Melanoma / diagnosis. Melanoma / genetics. Mutation / genetics. Uveal Neoplasms / diagnosis. Uveal Neoplasms / genetics

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  • (PMID = 19654573.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11
  • [Other-IDs] NLM/ PMC2736834
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22. Manns F, Parel JM, Denham D, Billotte C, Ziebarth N, Borja D, Fernandez V, Aly M, Arrieta E, Ho A, Holden B: Optomechanical response of human and monkey lenses in a lens stretcher. Invest Ophthalmol Vis Sci; 2007 Jul;48(7):3260-8
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  • METHODS: Cynomolgus monkey (n = 48; age: 3.8-11 years), rhesus monkey (n = 35; age: 0.7-17 years) and human (n = 20, age 8-70 years) eyes obtained postmortem, including the lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching system.
  • The load, lens diameter, inner ciliary body diameter, and lens power were measured at each step and the diameter- and power-load responses were quantified.

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  • (PMID = 17591897.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY014801; United States / NEI NIH HHS / EY / R01 EY014225; United States / NEI NIH HHS / EY / EY14225-01; United States / NEI NIH HHS / EY / F31EY015395; United States / NEI NIH HHS / EY / F31 EY015395; United States / NEI NIH HHS / EY / P30 EY14801
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS396538; NLM/ PMC3429371
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23. Dong XG, Xu YM, Yuan GQ, Shi WY, Xie LX, Wang SG: [Intraocular implantation of cyclosporine A drug delivery system in the treatment of experimental uveitis]. Zhonghua Yan Ke Za Zhi; 2005 Jul;41(7):636-41
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  • A large amount of inflammatory cells infiltration and marked tissue disorganization were found at ciliary body and retina in groups A and B.
  • [MeSH-minor] Animals. Drug Delivery Systems. Drug Implants. Female. Male. Rabbits. Random Allocation. Vitreous Body / metabolism

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  • (PMID = 16080900.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drug Implants; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine
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24. Cleary G, Spalton DJ, Zhang JJ, Marshall J: In vitro lens capsule model for investigation of posterior capsule opacification. J Cataract Refract Surg; 2010 Aug;36(8):1249-52
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  • The intact crystalline lens-zonule-ciliary body complex is dissected from the globe in one piece and pinned with 8 entomological pins through the ciliary body to a soft silicone ring with an internal diameter of 12.7 mm.

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  • [Copyright] Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20656145.001).
  • [ISSN] 1873-4502
  • [Journal-full-title] Journal of cataract and refractive surgery
  • [ISO-abbreviation] J Cataract Refract Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Torres VL, Allemann N, Erwenne CM: Ultrasound biomicroscopy features of iris and ciliary body melanomas before and after brachytherapy. Ophthalmic Surg Lasers Imaging; 2005 Mar-Apr;36(2):129-38
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  • [Title] Ultrasound biomicroscopy features of iris and ciliary body melanomas before and after brachytherapy.
  • BACKGROUND AND OBJECTIVE: To determine ultrasound biomicroscopy (UBM) features of iris and ciliary body melanomas before and after brachytherapy.
  • RESULTS: Before brachytherapy, UBM examination showed a solid mass in the iris, ciliary body, or both in all four cases and allowed its characterization, sizing, and positioning.
  • Two cases had a pigmented scleral lesion corresponding to the tumor location, but UBM did not detect any scleral infiltration at those sites.
  • Complications related to brachytherapy were demonstrated, including cataract, peripheral anterior synechiae at tumor location, and secondary scleral thinning.
  • CONCLUSION: UBM played an important role as a complementary diagnostic method for anterior uveal melanomas, particularly ciliary body melanomas, but also allowed therapeutic planning (brachytherapy or surgery) and follow-up after treatment.
  • [MeSH-major] Brachytherapy. Ciliary Body / ultrasonography. Iris Neoplasms / ultrasonography. Melanoma / ultrasonography. Uveal Neoplasms / ultrasonography

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  • (PMID = 15792314.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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26. Zhao X, Das AV, Soto-Leon F, Ahmad I: Growth factor-responsive progenitors in the postnatal mammalian retina. Dev Dyn; 2005 Feb;232(2):349-58
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  • However, recent observations suggest that another derivative of the optic neuroepithelium, the ciliary body, contains a mitotically quiescent population of neural progenitors that proliferate in the presence of growth factors and demonstrate properties of neural stem cells.
  • Given their marginal position and neural properties and potential, these cells may represent a residual population of retinal progenitors, analogous to those found in the ciliary marginal zone of fish and amphibians.

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • (PMID = 15637695.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Growth Substances; 0 / Ki-67 Antigen; G34N38R2N1 / Bromodeoxyuridine
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27. Hou HY, Wang YS, Xu JF, Zhang P, Su XN, Wang YC, Liu JP: [The distribution and phenotype of bone marrow-derived cells in mice's eyes after induction of choroidal neovascularization by laser photocoagulation]. Zhonghua Yan Ke Za Zhi; 2008 Mar;44(3):212-6
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  • GFP-labelled cells appeared in CNV lesions (including choroid beneath CNV lesion), neurosensory retina over CNV, corneoscleral limbus, ciliary body, optic disc and sclera, retina and choroid distant from CNV.
  • However, F4/80 + green cells can be also detected in neurosensory retina over CNV, corneoscleral limbus and ciliary body.

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  • (PMID = 18785543.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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28. Yadav UC, Subramanyam S, Ramana KV: Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci; 2009 May;50(5):2276-82
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  • Similarly increased expression of inflammatory markers iNOS and Cox-2 in ciliary body and retinal wall was also significantly inhibited by benfotiamine.
  • The increased phosphorylation of PKC and the activation of NF-kappaB in the ciliary body and in the retinal wall of EIU rat eyes were suppressed by benfotiamine.

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  • (PMID = 19136698.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM071036-05; United States / NIGMS NIH HHS / GM / R01 GM071036; United States / NIGMS NIH HHS / GM / GM71036; United States / NIGMS NIH HHS / GM / R01 GM071036-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Cytokines; 0 / Lipopolysaccharides; 0 / NF-kappa B; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, rat; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / Ptgs2 protein, rat; EC 2.7.11.13 / Protein Kinase C; X66NSO3N35 / Thiamine; Y92OUS2H9B / benphothiamine
  • [Other-IDs] NLM/ NIHMS115303; NLM/ PMC2685466
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29. Kim SI, Cha YJ, Park SE: A case report on the change of the refractive power after a blunt trauma. Korean J Ophthalmol; 2008 Mar;22(1):53-7
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  • The angle and depth of the anterior chamber, the ciliary body, and the choroids were examined by ultrasound biomicroscopy (UBM) over 3 months.
  • During the 3 months after the injury, we made comparisons between the menifest and the cycloplegic refractions, the depths of anterior chambers, the thickness of the lenses, the axial lengths, and the UBM-determined appearances of the angles and depths of the anterior chambers, the ciliary bodies, and the choroids in both eyes.
  • RESULTS: We suspect that the depth reduction in the anterior chamber, the increase in anterior to posterior lens diameter, and the edema in the ciliary body are all related to the change in the refractive power following the blunt trauma.
  • [MeSH-major] Ciliary Body / injuries. Eye Injuries / complications. Myopia / etiology. Wounds, Nonpenetrating / complications

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  • (PMID = 18323707.001).
  • [ISSN] 1011-8942
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2629954
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30. Sollosy M, Preda M, Simionescu C, Mărgăritescu C: [Histopathological changes in pseudoexfoliative syndrome]. Oftalmologia; 2007;51(2):100-7
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  • RESULTS: We have demonstrated in this study using this three coloration that the abnormal material is exfoliative material and not amyloid in all the ocular structures that were studied (conjunctiva, cornea, lens and ciliary body).
  • [MeSH-minor] Biopsy. Ciliary Body / pathology. Coloring Agents. Congo Red. Cornea / pathology. Hematoxylin. Humans. Lens, Crystalline / pathology. Microscopy, Electron

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  • (PMID = 17937045.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Coloring Agents; 3U05FHG59S / Congo Red; YKM8PY2Z55 / Hematoxylin
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31. Tsai JH, Freeman JM, Chan CC, Schwartz GS, Derby EA, Petersen MR, Holland EJ: A progressive anterior fibrosis syndrome in patients with postsurgical congenital aniridia. Am J Ophthalmol; 2005 Dec;140(6):1075-9
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  • Surgical findings indicated that the fibrotic membrane also can involve the ciliary body and anterior retina.


32. Doshi M, Marcus C, Bejjani BA, Edward DP: Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes. Exp Eye Res; 2006 Jan;82(1):24-32
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  • Previously, investigators have reported detection of Cyp1b1 mRNA in the ciliary body and epithelium and neuroepithelium in the developing mouse eye, employing in situ hybridization techniques.
  • Similarly, additional investigators have detected CYP1B1 mRNA in the iris, ciliary body, non-pigmented ciliary epithelial line, cornea, retinal-pigment epithelium, and retina in the human adult eye, using Northern blotting.
  • In the anterior segment anti-CYP1B1 immunoreactivity (IR) was detected early in fetal development in the primitive ciliary epithelium.
  • As well, the most intense CYP1B1 IR was in the non-pigmented ciliary epithelium.
  • CYP1B1 IR was primarily immunolocalized to the non-pigmented ciliary epithelium and early in fetal development.
  • These findings suggest that the abnormalities in the development of the trabecular meshwork in PCG may result from diminished or absent metabolism of important endogenous substrates in the ciliary epithelium due to non-functional CYP1B1 enzyme.
  • [MeSH-minor] Adult. Ciliary Body / chemistry. Ciliary Body / embryology. Cornea / chemistry. Cornea / embryology. Cytochrome P-450 CYP1B1. Female. Fetal Development. Humans. Immunohistochemistry / methods. Iris / chemistry. Iris / embryology. Male. Pregnancy. Pregnancy Trimester, First. Pregnancy Trimester, Second. Retina / chemistry. Retina / embryology. Statistics, Nonparametric. Trabecular Meshwork / chemistry. Trabecular Meshwork / embryology

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  • (PMID = 15979611.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES012072; United States / NIEHS NIH HHS / ES / R01 ES09878; United States / NEI NIH HHS / EY / R01 EY11780
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP1B1 protein, human; EC 1.14.14.1 / Cyp1b1 protein, mouse; EC 1.14.14.1 / Cytochrome P-450 CYP1B1
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33. Trastman-Caruso E, Dorairaj S, Barocas VH, Tello C, Liebmann JM, Ritch R: Pigment dispersion syndrome patients do not have larger-than-normal irides. J Glaucoma; 2010 Sep;19(7):493-6
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  • A radial image of the iris and ciliary body was taken at the temporal quadrant before and after accommodation with the patient looking at a standardized target.
  • Ciliary body thickness was measured 500 μm posterior to the scleral spur.
  • For all quantities measured (iris thickness at 500, 1000, 3000 μm; iris cross-sectional area; ciliary body thickness and area), there was no significant difference between the control group and the PDS group (P>0.35).
  • CONCLUSIONS: Iris cross-sectional area and thickness and ciliary body thickness were similar in the accommodated and unaccommodated states in PDS and controls.
  • [MeSH-major] Exfoliation Syndrome / diagnosis. Iris / pathology
  • [MeSH-minor] Accommodation, Ocular. Adult. Ciliary Body / pathology. Ciliary Body / ultrasonography. Female. Gonioscopy. Humans. Intraocular Pressure. Male. Microscopy, Acoustic. Middle Aged

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  • (PMID = 20164802.001).
  • [ISSN] 1536-481X
  • [Journal-full-title] Journal of glaucoma
  • [ISO-abbreviation] J. Glaucoma
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-15795
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Croft MA, Glasser A, Heatley G, McDonald J, Ebbert T, Dahl DB, Nadkarni NV, Kaufman PL: Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye. Invest Ophthalmol Vis Sci; 2006 Mar;47(3):1076-86
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  • [Title] Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye.
  • PURPOSE: The underlying causes of presbyopia, and the functional relationship between the ciliary muscle and lens during aging are unclear.
  • METHODS: Centripetal ciliary body and lens equator movements were measured during accommodation in 28 eyes of 21 rhesus monkeys (ages, 5.7-26 years) by goniovideography.
  • Narrowing of the angle between the anterior aspect of the ciliary body and the inner aspect of the cornea was used as a surrogate indicator of forward ciliary body movement during accommodation.
  • RESULTS: Average centripetal ciliary body movement in older eyes (age > or =17 years, n = 16) was approximately 20% (0.09 mm) less than in young eyes (age, 6-10 years, n = 6), but not enough to explain the 60% (0.21 mm) loss in centripetal lens movement nor the 76% (10.2 D) loss in accommodative amplitude.
  • Average forward ciliary body movement was 67% (49 degrees ) less in older (n = 11) versus young (n = 6) eyes.
  • Maximum accommodative amplitude correlated significantly with the amplitude of centripetal lens movement (0.02 +/- 0.003 mm/D; n = 28; P < 0.001) and with forward ciliary body movement (3.34 +/- 0.54 deg/D; n = 21; P = 0.01).
  • CONCLUSIONS: Decreased lens movement with age could be in part secondary to extralenticular age-related changes, such as loss of ciliary body forward movement.
  • Ciliary body centripetal movement may not be the limiting component in accommodation in the older eye.

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  • (PMID = 16505044.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY016665; United States / NEI NIH HHS / EY / R01 EY010213; United States / NEI NIH HHS / EY / R01 EY014651-03; United States / NEI NIH HHS / EY / EY014651-03; United States / NEI NIH HHS / EY / R01 EY014651
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Roller RA, Almond NB, Anderson W: Traumatic iridodialysis in a student naval aviator applicant. Aviat Space Environ Med; 2005 Feb;76(2):147-50
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  • This defect results from compression of the anterior-posterior aspect of the globe itself, which stretches the anterior ring segments and leads to the separation of the iris root from the ciliary body.
  • Establishing the diagnosis in aviators is important since any visual disturbance may incapacitate the pilot, resulting in a mishap or interference with completion of the mission.
  • [MeSH-major] Eye Injuries / diagnosis. Iris / injuries. Wounds, Nonpenetrating / diagnosis
  • [MeSH-minor] Adult. Aviation. Diagnosis, Differential. Humans. Male. Military Personnel. Visual Acuity

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  • (PMID = 15742834.001).
  • [ISSN] 0095-6562
  • [Journal-full-title] Aviation, space, and environmental medicine
  • [ISO-abbreviation] Aviat Space Environ Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Hermans EA, Dubbelman M, van der Heijde GL, Heethaar RM: Change in the accommodative force on the lens of the human eye with age. Vision Res; 2008 Jan;48(1):119-26
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  • In conclusion, the preservation of the net force delivered by the extralenticular ciliary body indicates that the causes of presbyopia must be ascribed to lenticular changes.
  • [MeSH-minor] Adult. Child. Ciliary Body / physiology. Finite Element Analysis. Humans. Middle Aged. Models, Biological. Presbyopia / physiopathology. Stress, Mechanical

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  • (PMID = 18054980.001).
  • [ISSN] 0042-6989
  • [Journal-full-title] Vision research
  • [ISO-abbreviation] Vision Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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37. Brennan R, Jan JE, Lyons CJ: Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology. Eye (Lond); 2007 Jul;21(7):901-8
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  • Melatonin is synthesized in the retina, lens, ciliary body as well as other parts of the body.

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  • (PMID = 17001324.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Number-of-references] 97
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38. Silverman RH, Cannata J, Shung KK, Gal O, Patel M, Lloyd HO, Feleppa EJ, Coleman DJ: 75 MHz ultrasound biomicroscopy of anterior segment of eye. Ultrason Imaging; 2006 Jul;28(3):179-88
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  • We scanned the ciliary body and cornea of a human eye six years post-LASIK.
  • The iris and ciliary body were visualized despite attenuation by the overlying sclera.
  • [MeSH-major] Ciliary Body / diagnostic imaging. Cornea / diagnostic imaging. Microscopy, Acoustic

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  • (PMID = 17147058.001).
  • [ISSN] 0161-7346
  • [Journal-full-title] Ultrasonic imaging
  • [ISO-abbreviation] Ultrason Imaging
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / P41 EB002182; United States / NIBIB NIH HHS / EB / R01 EB000238; United States / NIBIB NIH HHS / EB / EB000238; United States / NIBIB NIH HHS / EB / P41-EB2182
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS12503; NLM/ PMC1764628
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39. Ramaesh T, Williams SE, Paul C, Ramaesh K, Dhillon B, West JD: Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development. Exp Eye Res; 2009 Aug;89(2):263-73
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  • However, microphthalmia was more severe, corneal vascularisation occurred earlier (during fetal stages), pigmented cells were present in the vitreous and corneal stroma and the ciliary body was malformed or abnormal.


40. Sancho-Pelluz J, Wunderlich KA, Rauch U, Romero FJ, van Veen T, Limb GA, Crocker PR, Perez MT: Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci; 2008 Dec;49(12):5602-10
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  • Specific staining was observed only in cells found in the vitreous margin of the retina and in surrounding tissues (sclera, cornea, ciliary body, choroid).

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  • (PMID = 18641281.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD11b; 0 / Membrane Glycoproteins; 0 / Receptors, Immunologic; 0 / Sialic Acid Binding Ig-like Lectin 1; 0 / Siglec1 protein, mouse; 147336-22-9 / Green Fluorescent Proteins; GZP2782OP0 / N-Acetylneuraminic Acid
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41. Pedrigi RM, David G, Dziezyc J, Humphrey JD: Regional mechanical properties and stress analysis of the human anterior lens capsule. Vision Res; 2007 Jun;47(13):1781-9
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  • The lens capsule of the eye functions, in part, as a deformable support through which the ciliary body applies tractions that can alter lens curvature and corresponding refractive power during the process of accommodation.

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  • (PMID = 17467027.001).
  • [ISSN] 0042-6989
  • [Journal-full-title] Vision research
  • [ISO-abbreviation] Vision Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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42. Roy H: The red eye. Compr Ther; 2006;32(1):43-6
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  • Most cases are benign and can be managed by the primary care provider.
  • The key is recognizing cases requiring ophthalmological consultation by differentiating between ciliary and conjunctival injection.
  • Ciliary injection indicates inflammation of the cornea, iris, or ciliary body, whereas conjunctival injection mainly affects the posterior conjunctival blood vessels.
  • [MeSH-major] Eye Diseases / diagnosis. Eye Diseases / therapy
  • [MeSH-minor] Diagnosis, Differential. Eye Foreign Bodies / diagnosis. Eye Foreign Bodies / therapy. Humans

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  • (PMID = 16785582.001).
  • [ISSN] 0098-8243
  • [Journal-full-title] Comprehensive therapy
  • [ISO-abbreviation] Compr Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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43. Nesher R, Mechoulam H, Zamir E, Pe'er J: [Association between iris color and ciliary body pigmentation: possible implications for cyclophotoablation treatment]. Harefuah; 2008 Feb;147(2):131-3, 182
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  • [Title] [Association between iris color and ciliary body pigmentation: possible implications for cyclophotoablation treatment].
  • BACKGROUND: Cyclophotoablation for glaucoma treatment is dependent on the amount of laser energy absorbed by the ciliary body and related to the degree of its pigmentation.
  • Iris color may be assessed by observing the eye, but it is unknown whether it correlates with ciliary body pigmentation.
  • AIM: We evaluated whether ciliary pigmentation correlates with iris color.
  • METHODS: The pigmented epithelium of the ciliary processes of 31 enucleated eyes was qualitatively scored for six histological parameters and correlated with iris color.
  • CONCLUSION: Iris color correlates with ciliary pigmentation and may serve as one of the factors determining laser power needed for cyclophotoablation.
  • [MeSH-major] Ciliary Body / physiology. Corneal Surgery, Laser. Eye Color / physiology. Iris / physiology. Laser Therapy. Pigment Epithelium of Eye / physiology

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  • (PMID = 18357669.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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44. Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR: Cavitary choroidal melanoma. Can J Ophthalmol; 2005 Oct;40(5):619-22
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  • The results of ultrasonography, magnetic resonance imaging, computed tomography, and immunohistochemical studies are presented for a 38-year-old woman who developed an amelanotic tumor in the posterior choroid.
  • Enucleation was performed and histopathologic examination showed a choroidal melanoma of spindle cell type, with intratumoral cavitations lined by flattened tumor cells.
  • COMMENTS: The majority of previous reports of intraocular cavitary tumors describe cavitary ciliary body tumors.
  • Uveal melanoma should be included in the differential diagnosis of choroidal cavitary lesions.

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  • (PMID = 16391628.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Vimentin
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45. Peña MT, Naranjo C, Klauss G, Fondevila D, Leiva M, Roura X, Davidson MG, Dubielzig RR: Histopathological features of ocular leishmaniosis in the dog. J Comp Pathol; 2008 Jan;138(1):32-9
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  • Ocular tissues affected, in order of frequency, were conjunctiva and limbus, ciliary body, iris, cornea, sclera and iridocorneal angle, choroid and the optic nerve sheath.

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  • (PMID = 18048051.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Tolleson WH, Doss JC, Latendresse J, Warbritton AR, Melchior WB Jr, Chin L, Dubielzig RR, Albert DM: Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. Arch Ophthalmol; 2005 Aug;123(8):1088-94
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  • OBJECTIVE: To characterize a murine model of spontaneous amelanotic melanoma arising in the uvea of transgenic mice bearing a targeted deletion of the Ink4a/Arf tumor suppressor locus (exons 2 and 3) and expressing human H-ras controlled by the human tyrosinase promoter.
  • Tumor cells exhibited epithelioid and spindle-shaped morphological features and closely resembled the human counterpart.
  • CONCLUSION: Spontaneous uveal malignant melanomas occurring in male Tyr-RAS+ Ink4a/Arf-/- transgenic mice arise within the choroid or ciliary body and share histopathological features characteristic of human uveal melanoma.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Gene Deletion. Genes, ras / genetics. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Tumor Suppressor Protein p14ARF / genetics. Uveal Neoplasms / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Disease Models, Animal. Genotype. Male. Mice. Mice, Transgenic

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  • (PMID = 16087843.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 01917; United States / NCI NIH HHS / CA / R01 CA 93947
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 1.14.18.1 / Monophenol Monooxygenase
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47. Lindqvist A, He YG, Andersson S: Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. J Histochem Cytochem; 2005 Nov;53(11):1403-12
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  • By immunohistochemical analysis it was revealed that BCO2 was detected in cell types that are known to express BCO1, such as epithelial cells in the mucosa of small intestine and stomach, parenchymal cells in liver, Leydig and Sertoli cells in testis, kidney tubules, adrenal gland, exocrine pancreas, and retinal pigment epithelium and ciliary body pigment epithelia in the eye.

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  • (PMID = 15983114.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-62192
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / RNA, Messenger; EC 1.13.11.- / Dioxygenases; EC 1.14.19.- / Fatty Acid Desaturases; EC 1.14.99.- / BCO2 protein, human; EC 1.14.99.36 / beta-Carotene 15,15'-Monooxygenase
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48. Damato EM, Damato B, Sibbring JS, Coupland SE: Ciliary body melanoma with partial deletion of chromosome 3 detected with multiplex ligation-dependent probe amplification. Graefes Arch Clin Exp Ophthalmol; 2008 Nov;246(11):1637-40
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  • [Title] Ciliary body melanoma with partial deletion of chromosome 3 detected with multiplex ligation-dependent probe amplification.
  • BACKGROUND: The management of a patient with a small, pigmented ciliary body tumour is controversial, the various options including observation, radiotherapy, fine needle aspiration biopsy and excision biopsy.
  • We report a case of ciliary body melanoma with partial deletion of chromosome 3, which was missed with fluorescence in situ hybridization (FISH) but detected with multiplex ligation-dependent probe amplification (MLPA).
  • METHODS: A 23-year-old woman underwent an excision biopsy for a 4.5 mm by 3.9 mm by 2.0 mm ciliary body tumour, which was assessed by histology, immunohistochemistry, FISH and MLPA.
  • RESULTS: Histology showed the tumour to a melanoma of mixed cell type.
  • FISH with a centromeric probe indicated that the tumour was of disomy 3 type with a good prognosis; however, MLPA revealed a partial deletion of the long arm of chromosome 3.
  • To our knowledge this is the first reported case of ciliary body melanoma assessed by MLPA.
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human, Pair 3. Ciliary Body. Melanoma / genetics. Uveal Neoplasms / genetics

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  • [Cites] Diagn Mol Pathol. 2005 Mar;14(1):9-16 [15714058.001]
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  • (PMID = 18563430.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Probes
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49. Williams TA, Bansal A, Sung V: Early tractional ciliary body detachment in a uveitic eye after cataract surgery managed with circumferential anterior capsulectomy. Br J Ophthalmol; 2008 Mar;92(3):430-1
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  • [Title] Early tractional ciliary body detachment in a uveitic eye after cataract surgery managed with circumferential anterior capsulectomy.
  • [MeSH-major] Ciliary Body. Lens Capsule, Crystalline / surgery. Phacoemulsification / adverse effects. Uveal Diseases / etiology

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  • (PMID = 18303171.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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50. Ramulu P, Iliff NT, Green WR, Kuo IC: Asymptomatic conjunctival mucosa-associated lymphoid tissue-type lymphoma with presumed intraocular involvement. Cornea; 2007 May;26(4):484-6
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  • Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid.
  • A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population.
  • [MeSH-major] Choroid Neoplasms / pathology. Ciliary Body / pathology. Conjunctival Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Uveal Neoplasms / pathology

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  • (PMID = 17457201.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY 001765-29
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
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51. Mancini V, Battaglia M, Lucarelli G, Di Lorenzo V, Ditonno P, Bettocchi C, Selvaggi FP: Unusual solitary metastasis of the ciliary body in renal cell carcinoma. Int J Urol; 2008 Apr;15(4):363-5
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  • [Title] Unusual solitary metastasis of the ciliary body in renal cell carcinoma.
  • We describe a rare case of metachronous ciliary RCC metastasis in a 42-year-old man who had undergone left radical nephrectomy for conventional RCC (pT3aN0M0, G2 Fuhrman) 6 years earlier.
  • Solitary metastasis of the left eye presented with inflammatory symptoms, but examination of the fundus and bulbar ultrasound revealed a small mass of the ciliary body.
  • Ocular metastasis of RCC is rare, can appear years after treating the primary tumor and should not be excluded in RCC follow-up.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Ciliary Body / pathology. Kidney Neoplasms / pathology. Uveal Neoplasms / secondary

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  • (PMID = 18380830.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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52. Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP: Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp Eye Res; 2008 Oct;87(4):376-84
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  • Myocilin was also detected by immunohistochemistry in trabecular meshwork, ciliary body, iris, cornea, sclera, choroid, and retinal pigment epithelial cells.

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  • (PMID = 18674535.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY015736-04; United States / NEI NIH HHS / EY / EY007065-22; United States / NEI NIH HHS / EY / F32 EY007065; United States / NEI NIH HHS / EY / R01 EY014411; United States / NEI NIH HHS / EY / EY15736; United States / NEI NIH HHS / EY / R01 EY015736; United States / NEI NIH HHS / EY / R01 EY015736-04; United States / NEI NIH HHS / EY / EY14411; United States / NEI NIH HHS / EY / R01 EY007065-22; United States / NEI NIH HHS / EY / EY07065; United States / NEI NIH HHS / EY / R01 EY007065
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Culture Media, Conditioned; 0 / Cytoskeletal Proteins; 0 / Eye Proteins; 0 / Glycoproteins; 0 / Recombinant Proteins; 0 / trabecular meshwork-induced glucocorticoid response protein
  • [Other-IDs] NLM/ NIHMS72534; NLM/ PMC2866087
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53. Sharif NA, Kelly CR, Crider JY, Davis TL: Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. J Ocul Pharmacol Ther; 2006 Dec;22(6):389-401
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  • [Title] Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension.
  • PURPOSE AND METHODS: The aim of this study was to characterize the serotonin (5-hydroxytryptamine; 5-HT) receptors that mediate phosphoinositide (PI) hydrolysis and intracellular Ca2+ ([Ca2+]i) mobilization in isolated cells of human ciliary muscle (h-CM) from multiple donors using a variety of agonists and antagonists.
  • An additional aim was to visualize the mRNAs and receptor binding sites for 5-HT2 receptors in human ciliary body (h-CB), CM, and other tissues by reverse transcriptase polymerase chain reaction and quantitative autoradiography techniques, respectively, and to correlate with ocular hypotensive activity of such compounds.
  • [3H]-5-HT and [3H]-ketanserin autoradiography on sections of human eyes revealed a high density of 5-HT2 receptor binding sites in the iris, ciliary epithelium, and longitudinal CM.
  • [MeSH-major] Ciliary Body / metabolism. Muscle Cells / metabolism. Ocular Hypertension. Receptors, Serotonin, 5-HT2 / biosynthesis. Signal Transduction


54. Gao B, Huber RD, Wenzel A, Vavricka SR, Ismair MG, Remé C, Meier PJ: Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Exp Eye Res; 2005 Jan;80(1):61-72
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  • [Title] Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium.
  • PURPOSE: To identify and localize the expression of multispecific organic anion transporting polypeptides (Oatps/OATPs) in the ciliary body epithelium and to investigate their possible involvement in the transport of the antiglaucoma agent unoprostone.
  • METHODS: Oatps/OATPs were detected by immunoblot analysis and by immunofluorescence microscopy in homogenized and fixed rat and human ciliary body samples using specific polyclonal antibodies.
  • RESULTS: Immunoblots of ciliary body extracts were positive for rat Oatp1a4, Oatp1a5 and Oatp1b2 and for human OATP1A2, OATP1C1, OATP2B1, OATP3A1 and OATP4A1.
  • Confocal immunofluorescence microscopy localized Oatp1a4 and Oatp1b2 as well as all immunoblot positive human OATPs at the basolateral plasma membrane of the non-pigmented rat and human ciliary body epithelium, respectively.
  • However, for human OATPs additional regional differences in expression were found with OATP1A2 and OATP1C1 being expressed only in the pars plana of human ciliary body epithelium.
  • CONCLUSIONS: Several multispecific organic anion transporting polypeptides are expressed at the basolateral plasma membrane of the non-pigmented, and to a lesser extent also of the pigmented, epithelium in rat and human ciliary body.
  • These Oatps/OATPs can account for the previously suggested 'liver-like' transport functions of mammalian ciliary body epithelium.
  • [MeSH-major] Ciliary Body / metabolism. Dinoprost / analogs & derivatives. Organic Anion Transporters / analysis

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  • (PMID = 15652527.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transport Protein 1; 0 / Organic Anion Transporters; 0 / Peptides; 0 / SLCO3A1 protein, human; 0 / SLCO4A1 protein, human; 69553-75-9 / isopropyl unoprostone; B7IN85G1HY / Dinoprost
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55. Barraza RA, McLaren JW, Poeschla EM: Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure. Mol Ther; 2010 Mar;18(3):491-501
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  • We used lentiviral vectors to stably express COX-2 and other PG biosynthesis and response transgenes in the ciliary body epithelium and trabecular meshwork (TM), the ocular suborgans that produce aqueous humor and regulate its outflow, respectively.
  • [MeSH-minor] Animals. Aqueous Humor / metabolism. Cats. Ciliary Body / metabolism. Cyclooxygenase 2 / genetics. Disease Models, Animal. Humans. Lentivirus / genetics. Models, Genetic. Trabecular Meshwork / metabolism. Transgenes

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  • (PMID = 19953083.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY014411; United States / NEI NIH HHS / EY / EY14411
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prostaglandins; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC2839422
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56. Burdon KP, Sharma S, Hewitt AW, McMellon AE, Wang JJ, Mackey DA, Mitchell P, Craig JE: Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Mol Vis; 2008;14:1727-36
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  • RESULTS: Clusterin was identified in normal human iris, the ciliary body, lens capsule, optic nerve, and aqueous humor.

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  • (PMID = 18806885.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CLU protein, human; 0 / Clusterin
  • [Other-IDs] NLM/ PMC2542387
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57. Cerase A, De Francesco S, Citterio A, Hadjistilianou T, Malandrini A, Mastrangelo D, Toti P, Venturi C: Growth of congenital malignant teratoid medulloepithelioma of the ciliary body: a case study. J Neurooncol; 2010 Feb;96(3):443-8
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  • [Title] Growth of congenital malignant teratoid medulloepithelioma of the ciliary body: a case study.
  • The purpose of this study was to describe the growth pattern of congenital malignant teratoid medulloepithelioma of the ciliary body by reporting clinical and imaging findings with pathological correlation.
  • An 11-month-old little girl presented with a whitish-pink iris mass in the right eye resulting from a small ciliary body mass consistent with medulloepithelioma at both clinical and computed tomography (CT) findings.
  • The eye was then enucleated, and histology confirmed the diagnosis.
  • This uncommon case displays the natural history of congenital malignant teratoid medulloepithelioma of the ciliary body.
  • While the tumour might have been successfully treated by local excision at diagnosis, the delay in surgical treatment led to tumour overgrowth with consequent need for enucleation.
  • [MeSH-major] Brain Neoplasms. Ciliary Body / pathology. Neoplasms, Neuroepithelial. Neuroectodermal Tumors, Primitive

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  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
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  • [Publication-country] United States
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58. Yang H, Wang R, Gu Q, Zhang X: Feasibility study of chitosan as intravitreous tamponade material. Graefes Arch Clin Exp Ophthalmol; 2008 Aug;246(8):1097-105
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  • BACKGROUND: Chitosan can inhibit fibroblastic proliferation by suppressing fibroblast cells, and has the similar physiological characteristics as normal vitreous body, so it might have the potential to become vitreous filling material and might possibly inhibit proliferative vitreous retinopathy.
  • To investigate the possibility of chitosan as vitreous filling material, this study was designed to investigate retina, ciliary body, lens and cornea morphology changes, intraocular pressure and intraocular inflammatory factors fluctuating after chitosan intravitreous tamponade.
  • The concentration of IL-6, IL-8 (radioimmunoassay), NO (nitrate reductase method) in aqueous humor and vitreous body were tested at day 15 and day 30 post-op.
  • At day 30 post-op, the cornea, ciliary body, and lens were dissected for light microscopy examination, and the retinal tissues 2PD away from the optic disc on the vertical orientation of posterior pole were dissected for light- and electro-microscope examination.
  • In vitreous body at day 30 post-op, the concentrations of IL-8 in experimental group and control group were 10.17 +/- 3.63 ng/ml and 10.69 +/- 3.52 ng/ml, and those of NO were 50.23 +/- 19.69 micromol/mL and 50.60 +/- 12.72 micromol/mL respectively, all higher than in the blank control group (30.37 +/- 14.63 micromol/ml) (P < 0.05); the concentrations of IL-6 were 24.51 +/- 10.71 ng/ml and 26.36 +/- 13.00 ng/ml, no significant difference to the blank control group (24.06 +/- 5.98 ng/ml) (P > 0.05).
  • At various time points, there was no significant difference in the concentrations of IL-6, IL-8 and NO in aqueous humor and vitreous body in the experimental group and the control group (P > 0.05).
  • There was no morphological change found under light microscopy in cornea, ciliary body and lens.
  • [MeSH-minor] Animals. Aqueous Humor / metabolism. Ciliary Body / drug effects. Ciliary Body / pathology. Cornea / drug effects. Cornea / pathology. Feasibility Studies. Injections. Interleukin-6 / metabolism. Interleukin-8 / metabolism. Lens, Crystalline / drug effects. Lens, Crystalline / pathology. Nitric Oxide / metabolism. Rabbits. Vitrectomy. Vitreous Body / metabolism

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  • (PMID = 18431591.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Hemostatics; 0 / Interleukin-6; 0 / Interleukin-8; 31C4KY9ESH / Nitric Oxide; 9012-76-4 / Chitosan
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59. Paques M, Guyomard JL, Simonutti M, Roux MJ, Picaud S, Legargasson JF, Sahel JA: Panretinal, high-resolution color photography of the mouse fundus. Invest Ophthalmol Vis Sci; 2007 Jun;48(6):2769-74
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  • RESULTS: High-resolution digital imaging of the fundus, including the ciliary body, was routinely obtained.
  • TEFI significantly improves the quality of in vivo photography of retina and ciliary process of mice.

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  • (PMID = 17525211.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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60. Onyimba CU, Vijapurapu N, Curnow SJ, Khosla P, Stewart PM, Murray PI, Walker EA, Rauz S: Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye. J Endocrinol; 2006 Aug;190(2):483-93
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  • Recent descriptive studies have localised 11beta-HSD1 to the human corneal epithelium and non-pigmented epithelium (NPE) of the ciliary body, indicating a link to corneal epithelial physiology and aqueous humour production.
  • No staining was seen in the albino 'pigmented' ciliary epithelium.
  • Specific enzyme assays for oxo-reductase (cortisone-->cortisol) and dehydrogenase (cortisol-->cortisone) activity indicated predominant 11beta-HSD1 oxo-reductase activity from both the intact ciliary body tissue (n=12, median 2.1 pmol/mg per h and range 1.25-2.8 pmol/mg per h; P=0.006) and primary cultures of corneal epithelial cells (n=12, median 3.0 pmol/mg per h and range 1.0-7.4 pmol/mg per h, P=0.008) compared with dehydrogenase activity (median 1.0 pmol/mg per h and range 0.5-2.0 pmol/mg per h; median 0.5 pmol/mg per h and range 0.25-1.9 pmol/mg per h respectively).
  • These findings were supported by expression of 11beta-HSD1 protein as visualised by Western blotting of ciliary body tissue and immunocytochemistry of corneal epithelial cells.
  • The NZWAR provides a suitable in vivo model for the further evaluation of 11beta-HSD1 activity in the eye, especially its role in corneal epithelial and ciliary body physiology.
  • [MeSH-major] 11-beta-Hydroxysteroid Dehydrogenase Type 1 / analysis. Ciliary Body / metabolism. Epithelium, Corneal / metabolism. Glucocorticoids / metabolism

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  • (PMID = 16899581.001).
  • [ISSN] 0022-0795
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 1; V27W9254FZ / Cortisone; WI4X0X7BPJ / Hydrocortisone
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61. Pfeiffer-Guglielmi B, Francke M, Reichenbach A, Fleckenstein B, Jung G, Hamprecht B: Glycogen phosphorylase isozyme pattern in mammalian retinal Müller (glial) cells and in astrocytes of retina and optic nerve. Glia; 2005 Jan 1;49(1):84-95
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  • In contrast, astrocytes in the brain and spinal cord as well as the epithelial cells of the pars caeca and of the ciliary body express both the BB and MM isoform.
  • [MeSH-minor] Animals. Brain / cytology. Brain / enzymology. Ciliary Body / cytology. Ciliary Body / enzymology. Epithelial Cells / cytology. Epithelial Cells / enzymology. Glycogen / metabolism. Glycogen Phosphorylase, Brain Form / metabolism. Glycogen Phosphorylase, Muscle Form / metabolism. Guinea Pigs. Immunohistochemistry. Isoenzymes / metabolism. Mice. Rabbits. Rats. Rats, Inbred BN. Spinal Cord / cytology. Spinal Cord / enzymology

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  • [Copyright] copyright (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15390095.001).
  • [ISSN] 0894-1491
  • [Journal-full-title] Glia
  • [ISO-abbreviation] Glia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 9005-79-2 / Glycogen; EC 2.4.1.- / Glycogen Phosphorylase; EC 2.4.1.- / Glycogen Phosphorylase, Brain Form; EC 2.4.1.- / Glycogen Phosphorylase, Muscle Form
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62. Wiechmann AF, Summers JA: Circadian rhythms in the eye: the physiological significance of melatonin receptors in ocular tissues. Prog Retin Eye Res; 2008 Mar;27(2):137-60
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  • The diurnal changes in environmental illumination are conveyed by the retina to the brain to entrain circadian rhythms throughout the body.
  • The circadian signaling molecule, melatonin, is secreted into the circulation from the pineal gland, and is also produced within specific ocular cells such as retinal photoreceptors, ciliary epithelial cells, and perhaps cells of the lens.
  • Melatonin receptors have been identified in many ocular tissues, including the neural retina, retinal pigment epithelium, ciliary body, cornea, sclera, and lens.

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  • (PMID = 18316227.001).
  • [ISSN] 1350-9462
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY09391; United States / NEI NIH HHS / EY / EY13686
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Melatonin; JL5DK93RCL / Melatonin
  • [Number-of-references] 226
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63. Ozturk B, Buyukberber S, Coskun U, Yaman E, Yildiz R, Kaya AO, Oner Y, Benekli M: Solitary iris metastasis from breast cancer with dramatic course: case report. Med Oncol; 2007;24(4):463-5
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  • As a first metastatic site, iris and ciliary body are relatively rare.
  • Iris and ciliary metastases were diagnosed by ophthalmological examination.
  • Ciliary body and iris metastases of breast cancer must be considered as a manifestation of aggressive clinical course and poor prognosis.
  • [MeSH-major] Breast Neoplasms / pathology. Iris Neoplasms / diagnosis. Iris Neoplasms / secondary

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  • (PMID = 17917101.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Siu AW, Maldonado M, Sanchez-Hidalgo M, Tan DX, Reiter RJ: Protective effects of melatonin in experimental free radical-related ocular diseases. J Pineal Res; 2006 Mar;40(2):101-9
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  • In the eye, melatonin is produced in the retina and in the ciliary body.

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  • (PMID = 16441546.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antioxidants; JL5DK93RCL / Melatonin
  • [Number-of-references] 131
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65. Strakhov VV, Mineeva LA, Buzykin MA: [Involutional changes in the human eye accommodative apparatus as evidenced by ultrasound biometry and biomicroscopy]. Vestn Oftalmol; 2007 Jul-Aug;123(4):32-5
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  • The presbyopic patients were found to have a significantly diminished tone in the middle and posterior portions of the lenticular ligamentous apparatus to the extent of its sag, with the altered direction of their passage between the crystalline lenticular equator and the ciliary body crown, i. e. from meridional to radial.
  • [MeSH-major] Accommodation, Ocular. Ciliary Body / ultrasonography. Lens, Crystalline / ultrasonography. Microscopy, Acoustic / methods. Presbyopia / ultrasonography. Refraction, Ocular

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  • (PMID = 17802760.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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66. Colitz CM: Feline uveitis: diagnosis and treatment. Clin Tech Small Anim Pract; 2005 May;20(2):117-20
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  • [Title] Feline uveitis: diagnosis and treatment.
  • Uveitis is the inflammation of any or all parts of the vascular tunic of the eye; the vascular tunic includes the iris, the ciliary body, and choroid.
  • A good knowledge base, up-to-date reference materials, and good instruments will improve the diagnosis of uveitis.
  • Feline uveitis can be caused by numerous infectious agents in addition to neoplasia and less likely trauma.
  • Iris melanoma is the most common primary uveal neoplasia and trauma-associated sarcoma is the second most common primary uveal neoplasia.
  • Treatment for the clinical signs of anterior uveitis include topical steroidal or non-steroidal anti-inflammatory agents, parasympatholytic agents for ciliary spasm, to keep the pupil dilated, and to prevent posterior synechia.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / therapy. Uveitis / veterinary

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  • (PMID = 15948426.001).
  • [ISSN] 1096-2867
  • [Journal-full-title] Clinical techniques in small animal practice
  • [ISO-abbreviation] Clin Tech Small Anim Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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67. Mohamed MD, Gupta M, Parsons A, Rennie IG: Ultrasound biomicroscopy in the management of melanocytoma of the ciliary body with extrascleral extension. Br J Ophthalmol; 2005 Jan;89(1):14-6
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  • [Title] Ultrasound biomicroscopy in the management of melanocytoma of the ciliary body with extrascleral extension.
  • AIM: To demonstrate the ultrasound biomicroscopic features of a ciliary body melanocytoma with extrascleral extension, and a conservative approach in its management.
  • Two cases of ciliary body melanocytoma were suspected at presentation, confirmed histologically by biopsy, and subsequently monitored for change by serial ultrasound biomicroscopic imaging.
  • CONCLUSIONS: Melanocytoma is a rare tumour.
  • However if considered in the differential diagnosis at presentation and confirmed histologically, further management with use of the ultrasound biomicroscope as an accurate mode of imaging is an acceptable technique for preservation of the eye and avoids surgical excision.
  • [MeSH-major] Ciliary Body / ultrasonography. Nevus, Pigmented / ultrasonography. Uveal Neoplasms / ultrasonography

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  • (PMID = 15615738.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1772463
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68. Al-Jamal RT, Toivonen P, Kivelä T: Nucleolar size in choroidal and ciliary body melanomas and corresponding hepatic metastases. Acta Ophthalmol; 2010 Jun;88(4):458-62
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  • [Title] Nucleolar size in choroidal and ciliary body melanomas and corresponding hepatic metastases.
  • METHODS: A cross-sectional histopathological analysis of 37 metastases (13 surgical or needle biopsies, 24 autopsies) and corresponding primary choroidal and ciliary body melanomas was conducted, using statistical tests appropriate for paired data.
  • Hepatic metastases, especially in autopsy specimens rather than surgical biopsies, tended to have a smaller MLN (median 3.6 mum) than the corresponding primary tumour (median difference, 0.55 mum; p = 0.066).
  • Overall survival after diagnosis of metastasis was comparable whether hepatic metastases had a large or small MLN (p = 0.95), whereas a high MVD tended to be associated with shorter survival (p = 0.096) among the 13 patients with known survival.
  • CONCLUSIONS: The results suggest that MLN is not a useful marker for assessing prognosis after diagnosis of hepatic metastasis from uveal melanoma.

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  • (PMID = 19549104.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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69. Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW: B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci; 2006 Dec;47(12):5376-84
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  • Ciliary body PE cells did not promote conversion of T cells into Tregs.

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  • (PMID = 17122127.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY05678; United States / NEI NIH HHS / EY / EY11983
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD3; 0 / Antigens, CD86; 0 / Antigens, Differentiation; 0 / CTLA-4 Antigen; 0 / Cd86 protein, mouse; 0 / Ctla4 protein, mouse; 0 / Forkhead Transcription Factors; 0 / Foxp3 protein, mouse
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70. Xian J, Xu Q, Wang Z, Yang B, Wei W, Yan Z, Sun J, Shi J, Young GS: MR imaging of adenomas of the nonpigmented ciliary epithelium of the eye. AJNR Am J Neuroradiol; 2010 May;31(5):886-90
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  • [Title] MR imaging of adenomas of the nonpigmented ciliary epithelium of the eye.
  • BACKGROUND AND PURPOSE: ANPCEs are rare benign tumors of the eye arising from the NPCE in adults, which may be clinically mistaken for melanoma.
  • RESULTS: MR imaging revealed a circumscribed enhancing mass within the ciliary body of the eye in all 8 patients.
  • CONCLUSIONS: ANPCE should be included in the differential diagnosis of a spheric or ovoid enhancing ciliary body mass with T1 similar to that in the lacrimal gland and T2 equal to or longer than that in the lacrimal gland.
  • [MeSH-major] Adenoma / pathology. Ciliary Body / pathology. Magnetic Resonance Imaging / methods. Uveal Neoplasms / pathology

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  • (PMID = 20044507.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Kirwan C, Carney D, O'Keefe M: Merkel cell carcinoma metastasis to the iris in a 23 year old female. Ir Med J; 2009 Feb;102(2):53-4
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  • Histological diagnosis can be difficult and electron microscopy or immunohistochemistry are frequently required in addition to light microscopy.
  • Early diagnosis and complete surgical excision is associated with a favourable prognosis.
  • Intra-ocular metastases to the choroid and ciliary body have also been reported.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Fatal Outcome. Female. Humans. Mydriatics. Neoplasm Recurrence, Local / radiotherapy. Scalp

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  • (PMID = 19405321.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Mydriatics
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72. Bharti K, Nguyen MT, Skuntz S, Bertuzzi S, Arnheiter H: The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res; 2006 Oct;19(5):380-94
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  • Concomitantly with domain specification, the eye primordium progresses from a vesicle to a cup, RPE pigmentation extends towards the ventral side, and the future ciliary body and iris form from the margin zone between RPE and retina.

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  • (PMID = 16965267.001).
  • [ISSN] 0893-5785
  • [Journal-full-title] Pigment cell research
  • [ISO-abbreviation] Pigment Cell Res.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / Z01 NS002790-17; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] Denmark
  • [Number-of-references] 101
  • [Other-IDs] NLM/ NIHMS10499; NLM/ PMC1564434
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73. Higashiyama H, Kinoshita M, Asano S: Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray. Acta Histochem; 2008;110(1):86-93
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  • FXR immunolabeling was observed in the enterohepatic system--including absorptive epithelium in the intestines, hepatocytes and gall bladder epithelium, several epithelial lineage cells including the basal cells of stratified epithelium in the tongue, esophagus, forestomach--skin, corneal epithelium and ciliary body epithelium in the eye and adrenocortical cells--including glandular cells in the zona reticularis/fasciculata.

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  • (PMID = 17963822.001).
  • [ISSN] 0065-1281
  • [Journal-full-title] Acta histochemica
  • [ISO-abbreviation] Acta Histochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor
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74. Sharif NA: Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action. Curr Drug Targets; 2010 Aug;11(8):978-93
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  • The relative distribution and density of these mRNAs were as follows: ciliary body (CB) (5HT(2A) > 5HT(2B) > 5HT(2C)), ciliary epithelium (CE) (5HT(2A) > 5HT(2B) = 5HT(2C)) and trabecular meshwork (TM) (5HT(2A)= 5HT(2B) >> 5HT(2C)).
  • Furthermore, quantitative autoradiography revealed a relatively high specific binding of [(3)H]-5HT and [(3)H]-ketanserin to 5HT(2) receptors in human CE and longitudinal ciliary muscle (CM).

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  • (PMID = 20426763.001).
  • [ISSN] 1873-5592
  • [Journal-full-title] Current drug targets
  • [ISO-abbreviation] Curr Drug Targets
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Serotonin 5-HT2 Receptor Agonists; 0 / Serotonin Receptor Agonists
  • [Number-of-references] 102
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75. Georgouli T, Chang B, Nelson M, James T, Tanner S, Shelley D, Saldana M, McGonagle D: Use of high-resolution microscopy coil MRI for depicting orbital anatomy. Orbit; 2008;27(2):107-14
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  • The ciliary body and zonules of the lens are clearly visible.
  • Therefore, its introduction in routine clinical use can facilitate diagnosis and pre-operative planning in challenging cases.

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  • [CommentIn] Orbit. 2009;28(2-3):208 [19839916.001]
  • (PMID = 18415870.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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76. Reilly MA, Hamilton PD, Ravi N: Dynamic multi-arm radial lens stretcher: a robotic analog of the ciliary body. Exp Eye Res; 2008 Jan;86(1):157-64
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  • [Title] Dynamic multi-arm radial lens stretcher: a robotic analog of the ciliary body.
  • The lens stretcher acts as a robotic analog of the ciliary body.
  • [MeSH-major] Ciliary Body / physiology. Lens, Crystalline / physiology. Models, Anatomic. Robotics / instrumentation

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  • (PMID = 18068804.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY 02687
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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77. Schalenbourg A, Coupland S, Kacperek A, Damato B: Iridocyclectomy for neovascular glaucoma caused by proton-beam radiotherapy of pigmented ciliary adenocarcinoma. Graefes Arch Clin Exp Ophthalmol; 2008 Oct;246(10):1499-501
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  • [Title] Iridocyclectomy for neovascular glaucoma caused by proton-beam radiotherapy of pigmented ciliary adenocarcinoma.
  • PURPOSE: To report neovascular glaucoma after proton-beam radiotherapy of an adenocarcinoma of the pigmented ciliary epithelium and its successful treatment by iridocyclectomy.
  • PATIENT AND METHODS: A 65-year-old man developed neovascular glaucoma 10 months after proton-beam radiotherapy of a small pigmented iridociliary tumour with a clinical differential diagnosis of uveal melanoma or adenocarcinoma.
  • The diagnosis of 'toxic tumour syndrome' was made, and iridocyclectomy performed.
  • RESULTS: Histopathology and immunohistochemistry of the specimen diagnosed an adenocarcinoma of the pigmented ciliary epithelium, with the presence of mitoses suggesting residual viable tumour cells.
  • CONCLUSIONS: Neovascular glaucoma after radiotherapy of a small, pigmented, ciliary body tumour raises the possibility of adenocarcinoma.
  • This 'toxic tumour syndrome' may respond to iridocyclectomy of the irradiated tumour.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Ciliary Body / radiation effects. Glaucoma, Neovascular / surgery. Iridectomy. Radiation Injuries / surgery. Radiotherapy, Intensity-Modulated / adverse effects. Uveal Neoplasms / radiotherapy

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  • [Cites] Ophthalmology. 1999 Jan;106(1):103-10 [9917789.001]
  • (PMID = 18581131.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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78. Ohta K, Ito A, Tanaka H: Neuronal stem/progenitor cells in the vertebrate eye. Dev Growth Differ; 2008 May;50(4):253-9
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  • In this review, we highlight three potential stem/progenitor cells in the eye, the ciliary body epithelium cells, the iris pigmented epithelium cells, and Müller glia.

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  • (PMID = 18336580.001).
  • [ISSN] 1440-169X
  • [Journal-full-title] Development, growth & differentiation
  • [ISO-abbreviation] Dev. Growth Differ.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins
  • [Number-of-references] 41
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79. Goto K, Yasuda M, Sugawara A, Kuramochi T, Itoh T, Azuma N, Ito M: Small eye phenotypes observed in a human tau gene transgenic rat. Curr Eye Res; 2006 Jan;31(1):107-10
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  • The expression of hTau protein was evident immunohistochemically in the ciliary body, extraocular muscle, lens epithelium, and pigment epithelium.

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  • (PMID = 16421024.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / tau Proteins
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80. Kurt RA, Gündüz K: Exoresection via partial lamellar sclerouvectomy approach for uveal tumors: A successful performance by a novice surgeon. Clin Ophthalmol; 2010;4:59-65
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  • Exoresection was considered for tumors with their epicenter in the iris or in the ciliary body.
  • The histopathologic diagnosis was uveal malignant melanoma in 16 patients, iridociliary nevus in 2 patients, iris nevus in 2 patients, and iridociliary melanocytoma in 2 patients.
  • CONCLUSIONS: Exoresection seems to be an effective treatment option in selected cases of iridociliary and ciliary body tumors.

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  • (PMID = 20169050.001).
  • [ISSN] 1177-5483
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Keywords] NOTNLM ; choroid / choroidal melanoma / ciliary body / ciliary melanoma / ciliary nevus / ciliochoroidal melanoma / exoresection / iridociliochoroidal melanoma / iris / iris melanoma / iris nevus / partial lamellar sclerouvectomy / uveal melanoma / uveal nevus
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81. Jonescu-Cuypers CP, Seitz B: [Postoperative complications and management of filtration surgery]. Ophthalmologe; 2009 Nov;106(11):1029-39
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  • Fibrin reaction, corneal dellen, iris prolapse, conjunctival leakage and ciliary body detachment are seen more rarely.

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  • (PMID = 19908048.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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82. Ubaud C: [What should be done when surgery fails? Intraocular pressure remains too low after filtrating surgery]. J Fr Ophtalmol; 2006 May;29 Spec No 2:70-2
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  • The definition of postoperative hypotony should be based on intraocular pressure (<5 mmHg) but should also take into account the associated anatomical risk, risk factors as well as the mechanisms involved, which vary depending on whether the anterior or posterior segment is concerned (presence or absence of the Seidel sign, primary or secondary ciliary body and choroidal detachment, etc.).

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  • (PMID = 17072228.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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83. Zelefsky JR, Fine HF, Rubinstein VJ, Hsu IS, Finger PT: Escitalopram-induced uveal effusions and bilateral angle closure glaucoma. Am J Ophthalmol; 2006 Jun;141(6):1144-7
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  • A medical history and ophthalmic examination (including slit-lamp photography and high-frequency ultrasonography) were performed at the time of diagnosis and at resolution of her symptoms.
  • RESULTS: High-frequency ultrasonography revealed bilateral choroidal effusions with ciliary body detachments and angle closure.
  • [MeSH-minor] Acute Disease. Adult. Anterior Eye Segment / ultrasonography. Depressive Disorder / drug therapy. Exudates and Transudates. Female. Functional Laterality. Glucocorticoids / therapeutic use. Humans. Intraocular Pressure

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  • (PMID = 16765693.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Serotonin Uptake Inhibitors; 0DHU5B8D6V / Citalopram
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84. Stachs O, Schneider H, Stave J, Beck R, Guthoff RF: [Three-dimensional ultrasound biomicroscopic examinations for haptic differentiation of potentially accommodative intraocular lenses]. Ophthalmologe; 2005 Mar;102(3):265-71
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  • PURPOSE: The principal ability of potentially accommodative IOLs is based on an axial shift of the IOL optics induced by the ciliary body action in interaction with a reversible change in haptic angulation.

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  • (PMID = 15503052.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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85. Zhang Y, Burgess D, Overbeek PA, Govindarajan V: Dominant inhibition of lens placode formation in mice. Dev Biol; 2008 Nov 1;323(1):53-63
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  • The lens in the vertebrate eye has been shown to be critical for proper differentiation of the surrounding ocular tissues including the cornea, iris and ciliary body.
  • However, in these studies, lens ablation was initiated (and completed) after the cornea, retina, iris and ciliary body had initiated their differentiation programs thereby precluding analysis of the early role of the lens in fate determination of these tissues.
  • Initial specification of the presumptive ciliary body and iris at the anterior margins of the retina was not altered in the Tox176 mice but their subsequent differentiation was blocked.
  • These results suggest that, in mice, specification of the retina, ciliary body and iris occurs at the very outset of eye development and independent of the lens.

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  • (PMID = 18778700.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY017610; United States / NICHD NIH HHS / HD / P30 HD024064; United States / NEI NIH HHS / EY / R01 EY017610-02; United States / NEI NIH HHS / EY / R01 EY017610; United States / NEI NIH HHS / EY / EY017610-02; United States / NICHD NIH HHS / HD / P30HD24064
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Crystallins; 0 / Diphtheria Toxin
  • [Other-IDs] NLM/ NIHMS77206; NLM/ PMC2652847
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86. Yang P, Fang W, Jin H, Li B, Chen X, Kijlstra A: Clinical features of Chinese patients with Fuchs' syndrome. Ophthalmology; 2006 Mar;113(3):473-80
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  • Ultrasound biomicroscopy revealed exudates adjacent to the ciliary body in 18 of 24 patients (75%).
  • Exudates adjacent to the ciliary body and subclinical retinal and optic nerve involvement were common in the patients who were studied by UBM and FFA.
  • [MeSH-minor] Adolescent. Adult. Aged. Ciliary Body / metabolism. Exudates and Transudates / metabolism. Female. Fluorescein Angiography. Humans. Iridocyclitis / complications. Iris Diseases / etiology. Male. Middle Aged. Optic Nerve Diseases / etiology. Pigmentation Disorders / etiology. Retinal Diseases / etiology. Retrospective Studies. Syndrome. Vision Disorders / etiology

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  • (PMID = 16458965.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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87. Khan AO, Al-Assiri A: Lens coloboma associated with a ciliary body cyst. Ophthalmic Genet; 2007 Dec;28(4):208-9
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  • [Title] Lens coloboma associated with a ciliary body cyst.
  • The purpose of this report is to describe the association of lens coloboma with an adjacent cyst in the ciliary body and to suggest that ciliary body cysts may be an under-recognized cause of congenital lens coloboma.
  • [MeSH-major] Ciliary Body / pathology. Coloboma / complications. Cysts / complications

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  • (PMID = 18161620.001).
  • [ISSN] 1381-6810
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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88. Hu J, Tang SB, Ma J, Wu JL, Shen HX: [Experimental studies on the existence and distribution characteristics of neural stem cells in adult human ciliary body and retina]. Zhonghua Yan Ke Za Zhi; 2007 Mar;43(3):222-7
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  • [Title] [Experimental studies on the existence and distribution characteristics of neural stem cells in adult human ciliary body and retina].
  • OBJECTIVE: To investigate the existence and distribution characteristics of neural stem cells in the eyes of adult human ciliary body and retina.
  • The protein and mRNA expressions of neural progenitor cell-specific antigen nestin in the ciliary body and retina were detected by immunohistochemical staining and reverse RT-PCR assays, respectively.
  • RESULTS: Immunohistochemical staining showed that there were a few nestin-positive cells existed in pigment epithelium layer of ciliary body and inner nuclear layer (INL) of retina. mRNA expression of nestin gene was detected in both the ciliary body and retina of the infant and adult eyes by RT-PCR assays.
  • The expression of nestin in the infant ciliary body was higher than that of the adult eye.
  • CONCLUSION: Cells with the features of neural stem cells are present in the pigment epithelium layer of ciliary body and the inner nuclear layer of retina in adult human eyes.
  • [MeSH-major] Adult Stem Cells / ultrastructure. Ciliary Body / cytology. Intermediate Filament Proteins / metabolism. Nerve Tissue Proteins / metabolism. Retina / cytology

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  • (PMID = 17605904.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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89. Kiratli H, Bilgiç S, Söylemezoglu F: [Ciliary body leiomyomas. Three case reports]. J Fr Ophtalmol; 2005 Dec;28(10):1105-9
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  • [Title] [Ciliary body leiomyomas. Three case reports].
  • We present our experience with three patients, two of whom were women, 16, 28 and 44 years of age, presenting with leiomyomas of the ciliary body.
  • Although there are no specific clinical or imaging signs for intraocular leiomyoma, this tumor should be suspected when pigmented ciliary body tumors are encountered, especially in young female patients.
  • [MeSH-major] Ciliary Body. Leiomyoma / diagnosis. Uveal Neoplasms / diagnosis

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  • (PMID = 16395205.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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90. Shukla S, Damji KF, Harasymowycz P, Chialant D, Kent JS, Chevrier R, Buhrmann R, Marshall D, Pan Y, Hodge W: Clinical features distinguishing angle closure from pseudoplateau versus plateau iris. Br J Ophthalmol; 2008 Mar;92(3):340-4
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  • PURPOSE: To evaluate clinical aspects of patients with the diagnosis of plateau iris (PI) or pseudoplateau iris (PPI) made by ultrasound biomicroscopy (UBM) in order to determine if there are any clinical factors that can help differentiate between these two entities.
  • METHOD: A retrospective cohort of consecutive UBM patients with the diagnosis of PI or PPI.
  • The diagnosis of PI was based on an anteriorly positioned ciliary body that abutted the peripheral iris, a narrow (<10 degrees) or closed angle for at least 180 degrees, and the anterior portion of the iris positioned anterior to scleral spur.
  • The diagnosis of PPI was similar to plateau except that large or a cluster of small cysts had to be present in the iridociliary sulcus.
  • CONCLUSIONS: In patients being referred to a UBM clinic for evaluation of angle-closure mechanism, younger males with a bumpy peripheral iris have a higher likelihood of having a diagnosis of pseudoplateau iris.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ciliary Body / pathology. Ciliary Body / ultrasonography. Cysts / complications. Cysts / ultrasonography. Diagnosis, Differential. Female. Humans. Laser Therapy. Male. Microscopy, Acoustic. Middle Aged. Retrospective Studies


91. Ganea E, Harding JJ: Glutathione-related enzymes and the eye. Curr Eye Res; 2006 Jan;31(1):1-11
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  • The presence of glutathione, and of the related enzymes has been also reported in other parts of the eye, such as ciliary body and trabecular meshwork, suggesting that the same enzyme systems are present in all tissues of the eye to generate NADPH and to maintain gluthatione in the reduced form.

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  • (PMID = 16421014.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.49 / Glucosephosphate Dehydrogenase; EC 1.8.1.7 / Glutathione Reductase; GAN16C9B8O / Glutathione
  • [Number-of-references] 100
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92. Natiello M, Samuelson D: Three-dimensional reconstruction of the angioarchitecture of the ciliary body of the West Indian manatee (Trichechus manatus). Vet Ophthalmol; 2005 Nov-Dec;8(6):367-73
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  • [Title] Three-dimensional reconstruction of the angioarchitecture of the ciliary body of the West Indian manatee (Trichechus manatus).
  • OBJECTIVE: To examine the angioarchitecture of the ciliary body in the West Indian manatee (Trichechus manatus), through the use of three-dimensional reconstruction.
  • RESULTS: The network of blood vessels in the ciliary processes of the West Indian manatee is fed by the major arterial circle that lies mostly near the base of the iris.
  • CONCLUSIONS: The angioarchitecture of the ciliary body of the West Indian manatee is clearly unique when compared to those previously examined in land mammals.
  • [MeSH-major] Ciliary Body / anatomy & histology. Ciliary Body / blood supply. Imaging, Three-Dimensional / veterinary. Trichechus manatus / anatomy & histology

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  • (PMID = 16359359.001).
  • [ISSN] 1463-5216
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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93. Abi-Ayad N, Grange JD, Watkin E, De Bats M, Fleury J, Kodjikian L, Gambrelle J: [Ring melanoma revealed by spontaneous hyphema]. J Fr Ophtalmol; 2007 Sep;30(7):729-32
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  • INTRODUCTION: Ring melanoma is a rare form of uveal melanoma characterized by the circumferential involvement of the ciliary body.
  • Unilateral chronic and refractory glaucoma is a classic circumstance of diagnosis.
  • Iris and iridocorneal angle were diffusely invaded by the tumor.
  • The fundus was masked but B-scan ultrasonography revealed a voluminous ciliochoroidal tumor.
  • Pathological examination confirmed the diagnosis of ring melanoma.
  • The tumor involved angle structures.
  • DISCUSSION: Acute or chronic ocular hypertonia is a classic but rare circumstance of uveal melanoma diagnosis.
  • Many mechanisms exist: neovascular glaucoma, secondary angle closure, involvement of angle structures, and trabecular obstruction by tumor cells or pigment.
  • [MeSH-major] Choroid Neoplasms / diagnosis. Hyphema / etiology. Melanoma / diagnosis

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  • (PMID = 17878826.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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94. Curtin J, Moloney G, Grigg J, Sharota Franzco D: Clinical characterization and proposed mechanism of juvenile glaucoma--a patient with a chromosome 4p deletion, Wolf-Hirschhorn Syndrome. Ophthalmic Genet; 2010 Sep;31(3):135-8
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  • Six other patients have been described with Wolf-Hirschhorn syndrome (WHS) and glaucoma, most being congenital glaucoma with diagnosis in infancy.
  • Our patient had narrow angles on gonioscopy, with ultrasound biomicroscopy revealing ciliary body cysts.
  • [MeSH-minor] Antihypertensive Agents / therapeutic use. Ciliary Body / pathology. Ciliary Body / ultrasonography. Cysts / ultrasonography. Gonioscopy. Humans. Intraocular Pressure. Male. Microscopy, Acoustic. Uveal Diseases / ultrasonography. Young Adult

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  • (PMID = 20569021.001).
  • [ISSN] 1744-5094
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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95. Lumbroso-Le Rouic L, Delacroix S, Dendale R, Levy-Gabriel C, Feuvret L, Noel G, Plancher C, Nauraye C, Garcia P, Calugaru V, Asselain B, Desjardins L: Proton beam therapy for iris melanomas. Eye (Lond); 2006 Nov;20(11):1300-5
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  • Ciliary body melanomas with iris involvement or tumours with extrascleral invasion were excluded.
  • Treatment consisted of 60 Gy of proton beam irradiation delivered in four fractions to the tumour volume.
  • The iridocorneal angle was invaded by the tumour in 71.4% of patients.
  • None of the patients showed tumour progression or ocular relapse.
  • The tumour response at 2 years was a flat lesion for 6.3% of cases, partial regression in 75% and stable in 18.8%.
  • CONCLUSIONS: Proton beam therapy shows potential utility for selected cases of localised iris melanomas allowing excellent local tumour control and eye preservation.

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  • (PMID = 16294207.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protons
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96. Hussein MR: Analysis of Bcl-2 protein expression in choroidal melanomas. J Clin Pathol; 2005 May;58(5):486-9
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  • RESULTS: Bcl-2 protein expression was seen in corneal epithelium, lens epithelium, the ciliary body, and retinal cells.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ciliary Body / chemistry. Epithelium, Corneal / chemistry. Female. Humans. Lens, Crystalline / chemistry. Male. Middle Aged. Retina / chemistry

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  • (PMID = 15858118.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
  • [Other-IDs] NLM/ PMC1770663
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97. Bernal A, Parel JM, Manns F: Evidence for posterior zonular fiber attachment on the anterior hyaloid membrane. Invest Ophthalmol Vis Sci; 2006 Nov;47(11):4708-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A custom-made device was designed to mount human cadaveric lenses, with the zonule, ciliary body, and sclera attached, inside an environmental scanning electron microscope (ESEM).
  • Anterior view micrographs showed that posterior zonular fibers originate from the ciliary body and anchor in the hyaloid membrane.
  • CONCLUSIONS: Contrary to the classic description, the majority of posterior zonular fibers are not attached directly to the posterior lens capsule, but are anchored to the anterior hyaloid membrane on their path from the ciliary body to the posterior capsule.
  • [MeSH-major] Lens Capsule, Crystalline / ultrastructure. Ligaments / ultrastructure. Vitreous Body / ultrastructure

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  • (PMID = 17065477.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 14225; United States / NEI NIH HHS / EY / P30 EY 014801
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Sihota R, Dada T, Aggarwal A, Srinivasan G, Gupta V, Chabra VK: Does an iridotomy provide protection against narrowing of the anterior chamber angle during Valsalva maneuvre in eyes with primary angle closure. Eye (Lond); 2008 Mar;22(3):389-93
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  • There was a significant increase in the thickness of the ciliary body from 0.92+0.25 to 1.17+0.31 mm (P=0.0006) and in the iris thickness from 0.47+0.17 to 0.57+0.11 mm (P=0.007).
  • The angle recess during Valsalva had a positive correlation with the baseline anterior chamber angle (r=0.41, P=0.05) and a negative correlation with the ciliary body thickness (r=-0.52, P=0.046).

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  • (PMID = 17417624.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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99. Peizeng Y, Qianli M, Xiangkun H, Hongyan Z, Li W, Kijlstra A: Longitudinal study of anterior segment inflammation by ultrasound biomicroscopy in patients with acute anterior uveitis. Acta Ophthalmol; 2009 Mar;87(2):211-5
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  • RESULTS: All investigated AAU patients showed severe ciliary injection, numerous dust keratic precipitates (KPs), aqueous flare and inflammatory cells, and were treated predominantly with corticosteroid and cycloplegic eyedrops.
  • Ultrasound biomicroscopy showed a large number of cells in the anterior and posterior chamber, marked oedema and exudates in and around the iris and ciliary body within 2 weeks of AAU onset.
  • CONCLUSIONS: Ultrasound biomicroscopy reveals severe inflammatory changes in and around the ciliary body in patients with AAU.

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  • (PMID = 18811638.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Mydriatics; 0 / Ophthalmic Solutions
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100. Deo M, Yu JY, Chung KH, Tippens M, Turner DL: Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev Dyn; 2006 Sep;235(9):2538-48
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  • Whereas miR-124a is expressed in neurons, miR-9 is expressed in neural progenitors and some neurons, and miR-204 is expressed in the choroid plexus, retinal pigment epithelium, and ciliary body. miR-204 is located in an intron of the TRPM3 gene, and the TRPM3 mRNA is coexpressed with miR-204 in the choroid plexus.

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • [ErratumIn] Dev Dyn. 2007 Mar;236(3):912
  • (PMID = 16736490.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MIRN204 microRNA, mouse; 0 / MicroRNAs; 0 / Oligonucleotide Probes; 0 / Oligoribonucleotides; TPY09G7XIR / Fluorescein
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