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1. Huang CL: Regulation of ion channels by secreted Klotho: mechanisms and implications. Kidney Int; 2010 May;77(10):855-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choroid plexus of the brain.

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  • (PMID = 20375979.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 0 / Ion Channels; 0 / Ions; 0 / Receptors, Fibroblast Growth Factor
  • [Number-of-references] 39
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2. Proniewvska-Skretek E, Wojnar M, Mariak Z, Zalewska R: [Genetic abnormalities underlying formation of choroidal melanoma]. Klin Oczna; 2005;107(1-3):140-2
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  • Neoplastic transformation in the choroid can be triggered as a consequence of the following genetic alterations: --deletions and/or amplifications in the genetic material, usually in the chromosome 3, 6, 8, 9, 11, and 18; --point mutations, especially within some egzones, which leads to monosomia or loss of heterozygosity of the chromosome.
  • [MeSH-major] Choroid Neoplasms / genetics. Melanoma / genetics

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  • (PMID = 16052827.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 14
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3. Labasque M, Meffre J, Carrat G, Becamel C, Bockaert J, Marin P: Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants. Mol Pharmacol; 2010 Nov;78(5):818-26
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  • Similar observations were made in vivo in mouse choroid plexus, a structure rich in constitutively active 5-HT(2C) receptors.
  • [MeSH-minor] Animals. Arrestins / metabolism. Calmodulin / genetics. Calmodulin / metabolism. Cell Line. Choroid Plexus / drug effects. Choroid Plexus / metabolism. Drug Inverse Agonism. Enzyme Activation. Humans. In Vitro Techniques. Male. Mice. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Mutation. Phosphorylation. Protein Multimerization. Rats. Rats, Sprague-Dawley. Serotonin 5-HT2 Receptor Agonists / pharmacology. Serotonin 5-HT2 Receptor Antagonists / pharmacology. Signal Transduction

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  • (PMID = 20699324.001).
  • [ISSN] 1521-0111
  • [Journal-full-title] Molecular pharmacology
  • [ISO-abbreviation] Mol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Arrestins; 0 / Calmodulin; 0 / Receptor, Serotonin, 5-HT2C; 0 / Serotonin 5-HT2 Receptor Agonists; 0 / Serotonin 5-HT2 Receptor Antagonists; 0 / beta-arrestin; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.6.1.- / GTP-Binding Proteins
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4. Smith-Bindman R, Chu P, Goldberg JD: Second trimester prenatal ultrasound for the detection of pregnancies at increased risk of Down syndrome. Prenat Diagn; 2007 Jun;27(6):535-44
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  • In the absence of a structural anomaly, the isolated ultrasound soft markers of choroid plexus cyst, echogenic bowel, renal pyelectasis, clenched hands, clinodactyly, two-vessel umbilical cord, short femur, and short humerus were not associated with Down syndrome.
  • The genetic sonogram should not be used as a sequential test following serum biochemistry, as this would substantially reduce the prenatal diagnosis of Down syndrome cases.


5. Troilo D, Nickla DL, Mertz JR, Summers Rada JA: Change in the synthesis rates of ocular retinoic acid and scleral glycosaminoglycan during experimentally altered eye growth in marmosets. Invest Ophthalmol Vis Sci; 2006 May;47(5):1768-77
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  • In the same eyes the rate of RA synthesis in vivo was measured separately in the retina and the choroid/RPE (choroid with RPE attached) by HPLC.
  • RESULTS: Induced changes in vitreous chamber length in diffuser-treated eyes correlated inversely with the rate of scleral GAG synthesis (P < 0.05) and directly correlated with the rate of RA synthesis measured separately in the retina (P < 0.05) and the choroid/RPE (P < 0.05).
  • In group 1, the rate of scleral GAG synthesis was significantly lower (P < 0.01) in the treated eyes relative to control eyes, and the rate of RA synthesis in both the retina and the choroid/RPE was significantly higher (P < 0.01).
  • In group 2, the rates of scleral GAG synthesis and RA synthesis in either the retina or choroid/RPE were not found to change significantly in the treated eyes compared with the control eyes.

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  • (PMID = 16638980.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY011228; United States / NEI NIH HHS / EY / EY011228; United States / NEI NIH HHS / EY / R01 EY009391; United States / NEI NIH HHS / EY / EY09391; United States / NEI NIH HHS / EY / R24 EY014817
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycosaminoglycans; 5688UTC01R / Tretinoin; 9007-49-2 / DNA
  • [Other-IDs] NLM/ NIHMS22359; NLM/ PMC1892188
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6. Campos M, Amaral J, Becerra SP, Fariss RN: A novel imaging technique for experimental choroidal neovascularization. Invest Ophthalmol Vis Sci; 2006 Dec;47(12):5163-70
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  • Immediately after laser exposure, a circular area devoid of fluorescent labeling was observed, indicating disruption of the choroid-Bruch's membrane-RPE complex.
  • CONCLUSIONS: A novel imaging technique was developed that allows a three-dimensional reconstruction and measurement of laser-induced CNV lesions in rat choroid/RPE flatmounts.

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  • (PMID = 17122098.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD11b; 0 / Biomarkers; 0 / Fluorescent Dyes; 0 / Glycoproteins; 0 / Indoles; 0 / Lectins; 0 / fluorescein isothiocyanate dextran; 0 / isolectin B4-binding glycoprotein, rat; 17466-45-4 / Phalloidine; 47165-04-8 / DAPI; I223NX31W9 / Fluorescein-5-isothiocyanate; K3R6ZDH4DU / Dextrans
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7. Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y: Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology; 2010 Feb;117(2):303-12.e1
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  • There were no correlates to the deposits seen under the RPE or in the choroid.
  • [MeSH-major] Macular Degeneration / diagnosis. Retinal Drusen / diagnosis

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  • [Copyright] Copyright (c) 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19815280.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Clardy SL, Wang X, Boyer PJ, Earley CJ, Allen RP, Connor JR: Is ferroportin-hepcidin signaling altered in restless legs syndrome? J Neurol Sci; 2006 Sep 25;247(2):173-9
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  • Restless legs syndrome (RLS) is a neurological disorder characterized by a strong urge to move the legs.
  • Therefore, we provide immunocytochemical evidence that ferroportin is expressed by the epithelial cells of the choroid plexus and the ependymal cells lining the ventricles.

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  • (PMID = 16759669.001).
  • [ISSN] 0022-510X
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Cation Transport Proteins; 0 / HAMP protein, human; 0 / Hepcidins; 0 / metal transporting protein 1
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9. Sung WS, Dubey A, Erasmus A, Hunn A: Solitary choroid plexus metastasis from carcinoma of the oesophagus. J Clin Neurosci; 2008 May;15(5):594-7
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  • [Title] Solitary choroid plexus metastasis from carcinoma of the oesophagus.
  • Metastatic tumors to the brain presenting exclusively in the choroid plexus are rare and are most frequently associated with renal cell carcinoma.
  • In this paper, the authors report an unusual case of intraventricular metastasis, and to the authors' knowledge, this is the first case of solitary metastasis from oesophageal carcinoma to the choroid plexus to be described in the literature.
  • Metastatic disease is an important differential diagnosis which must be considered even for a patient without a documented primary malignancy who presents with a single lesion in the ventricle.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / secondary. Choroid Plexus Neoplasms / secondary. Esophageal Neoplasms / pathology

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  • (PMID = 18313927.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 24
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10. Avetisov SE, Likhvantseva VG, Reshetnikov AV, Fedorov AA, Vereshchagina MV, Balaian ML, Krupnov RN: [Russian photosensitizer radachlorine in photodynamic therapy for epibulbar and choroid tumors: experimental studies]. Vestn Oftalmol; 2005 Sep-Oct;121(5):9-13
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  • [Title] [Russian photosensitizer radachlorine in photodynamic therapy for epibulbar and choroid tumors: experimental studies].
  • The authors used the Russian agent Radachlorine as a photosensitizer (PS) in photodynamic therapy (PDT) for epibulbar and chorioid tumors.
  • [MeSH-major] Choroid Neoplasms / drug therapy. Eye Neoplasms / drug therapy. Melanoma, Experimental / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use
  • [MeSH-minor] Animals. Fluorescein Angiography. Male. Mice. Neoplasm Transplantation. Rabbits. Radiation Dosage. Recurrence. Time Factors. Treatment Outcome

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  • (PMID = 16274055.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 19660-77-6 / chlorin e6
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11. Nixon PF: Glutamate export at the choroid plexus in health, thiamin deficiency, and ethanol intoxication: review and hypothesis. Alcohol Clin Exp Res; 2008 Aug;32(8):1339-49
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  • [Title] Glutamate export at the choroid plexus in health, thiamin deficiency, and ethanol intoxication: review and hypothesis.
  • INTRODUCTION: The earliest observed effect in the pathogenesis of experimental Wernicke's encephalopathy and of ethanol intoxication in rats is impairment of the blood cerebrospinal fluid (CSF) barrier at the choroid plexus (CP).
  • [MeSH-major] Alcoholic Intoxication / metabolism. Choroid Plexus / metabolism. Glutamates / metabolism. Thiamine Deficiency / metabolism

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  • (PMID = 18616670.001).
  • [ISSN] 1530-0277
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glutamates; 3K9958V90M / Ethanol; IY9XDZ35W2 / Glucose
  • [Number-of-references] 109
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12. Steinle JJ, Cappocia FC Jr, Jiang Y: Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells. Growth Factors; 2008 Dec;26(6):325-30
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  • Modulation of this signaling in the choroid may offer a new avenue for therapeutics.
  • [MeSH-major] Adrenergic beta-Agonists / pharmacology. Choroid / metabolism. Endothelial Cells / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Isoproterenol / pharmacology. Receptors, Adrenergic, beta / metabolism. Up-Regulation

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  • (PMID = 19021032.001).
  • [ISSN] 1029-2292
  • [Journal-full-title] Growth factors (Chur, Switzerland)
  • [ISO-abbreviation] Growth Factors
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG027827-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Angiopoietin-1; 0 / Eye Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Nerve Growth Factors; 0 / Receptors, Adrenergic, beta; 0 / Serpins; 0 / Vascular Endothelial Growth Factor A; 0 / pigment epithelium-derived factor; L628TT009W / Isoproterenol
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13. Bourges JL, Bloquel C, Thomas A, Froussart F, Bochot A, Azan F, Gurny R, BenEzra D, Behar-Cohen F: Intraocular implants for extended drug delivery: therapeutic applications. Adv Drug Deliv Rev; 2006 Nov 15;58(11):1182-202
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  • For ocular diseases affecting the choroid and outer retina, transscleral or intrasscleral implants are gaining momentum.

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  • (PMID = 17107737.001).
  • [ISSN] 0169-409X
  • [Journal-full-title] Advanced drug delivery reviews
  • [ISO-abbreviation] Adv. Drug Deliv. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drug Implants; 0 / Pharmaceutical Preparations; 0 / Polymers
  • [Number-of-references] 141
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14. Tran HV, Zografos L: Primary choroidal melanoma in phakomatosis pigmentovascularis IIa. Ophthalmology; 2005 Jul;112(7):1232-5
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  • Ocular melanocytosis also was present unilaterally in all patients involving the sclera, the iris, the choroid, the distribution of the trigeminal nerve, or a combination thereof.
  • [MeSH-major] Choroid Neoplasms / complications. Melanoma / complications. Melanosis / complications. Nevus, Pigmented / complications. Port-Wine Stain / complications

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  • (PMID = 15939474.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Wills NK, Ramanujam VM, Kalariya N, Lewis JR, van Kuijk FJ: Copper and zinc distribution in the human retina: relationship to cadmium accumulation, age, and gender. Exp Eye Res; 2008 Aug;87(2):80-8
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  • Thus, we assessed the distribution of zinc and copper in the neural retina, retinal pigment epithelium (RPE) and choroid (Bruch's membrane-choroid;.
  • In the choroid, mean Cu and Zn levels were higher in aged donors (>or=55 years old) than young donors (<55 years) and levels of these metals were strongly correlated with each other (r=0.90).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cadmium / metabolism. Child. Child, Preschool. Choroid / metabolism. Copper / metabolism. Female. Humans. Infant. Male. Middle Aged. Retinal Pigment Epithelium / metabolism. Sex Characteristics. Spectrophotometry, Atomic / methods. Zinc / metabolism

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  • (PMID = 18579132.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metals, Heavy; 00BH33GNGH / Cadmium; 789U1901C5 / Copper; J41CSQ7QDS / Zinc
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16. Vogel T, Gruss P: Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse. Gene Expr Patterns; 2009 Feb;9(2):83-93
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  • This study shows for the first time, that murine Af9 is transcribed in various CNS structures including the subventricular zone (SVZ) of the cerebral cortex, hippocampus, cerebellar cortex, septum and various thalamic structures, the choroid plexus, and the midbrain/hindbrain boundary.

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  • (PMID = 19000783.001).
  • [ISSN] 1567-133X
  • [Journal-full-title] Gene expression patterns : GEP
  • [ISO-abbreviation] Gene Expr. Patterns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aff1 protein, mouse; 0 / Aff2 protein, mouse; 0 / Cutl2 protein, mouse; 0 / DNA-Binding Proteins; 0 / Homeodomain Proteins; 0 / Mllt1 protein, mouse; 0 / Mllt3 protein, mouse; 0 / Nuclear Proteins; 0 / Transcription Factors
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17. Kadam RS, Kompella UB: Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve. J Pharmacol Exp Ther; 2010 Mar;332(3):1107-20
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  • [Title] Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve.
  • In intact tissue methods, Kt:b followed the order choroid-retinal pigment epithelium (RPE) > trabecular meshwork > retina > sclera approximately optic nerve; propranolol > betaxolol > pindolol approximately timolol approximately metoprolol > sotalol approximately atenolol approximately nadolol.
  • Log (melanin binding capacity) correlated positively with choroid-RPE log (Kt:b) (R(2) of 0.5).
  • With an increase in concentration, Kt:b decreased in trabecular meshwork for all beta-blockers and for some lipophilic beta-blockers in choroid-RPE and sclera.
  • With an increase in drug lipophilicity, in vivo tissue distribution increased in choroid-RPE, iris-ciliary body, sclera, and cornea but exhibited a declining trend in retina, vitreous, and lens.
  • In vitro bovine intact tissue, wet weight Kt:b correlated positively with rat in vivo tissue/vitreous humor distribution for sclera, choroid-RPE, and retina (R(2) of 0.985-0.993).
  • Less lipophilic solutes exhibiting limited nonproductive binding in choroid-RPE might exhibit greater trans-scleral delivery to the retina and vitreous.

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  • (PMID = 19926800.001).
  • [ISSN] 1521-0103
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY017533; United States / NEI NIH HHS / EY / R01 EY017533-04A2; United States / NEI NIH HHS / EY / EY017533
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Melanins
  • [Other-IDs] NLM/ PMC2835449
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18. Koç A, Arisoy O, Pala E, Erdem M, Kaymak AO, Erkal O, Karaoğuz MY: Prenatal diagnosis of mosaic ring 22 duplication/deletion with terminal 22q13 deletion due to abnormal first trimester screening and choroid plexus cyst detected on ultrasound. J Obstet Gynaecol Res; 2009 Oct;35(5):978-82
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  • [Title] Prenatal diagnosis of mosaic ring 22 duplication/deletion with terminal 22q13 deletion due to abnormal first trimester screening and choroid plexus cyst detected on ultrasound.
  • We report a rare case of mosaic ring chromosome 22 duplication/deletion in a fetus for whom karyotype analysis was required because of an abnormal finding in the maternal serum screening test and a choroid plexus cyst detected on prenatal ultrasound.
  • We discuss the prenatal diagnosis of this rare condition.
  • [MeSH-major] Central Nervous System Cysts / ultrasonography. Choroid Plexus / ultrasonography. Choroid Plexus Neoplasms / ultrasonography. Chromosome Deletion. Chromosomes, Human, Pair 22. Mosaicism. Ring Chromosomes
  • [MeSH-minor] Abortion, Induced. Female. Genetic Testing. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Pregnancy. Pregnancy Trimester, First / genetics. Prenatal Diagnosis. Ultrasonography, Prenatal

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  • (PMID = 20149051.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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19. Marques F, Sousa JC, Coppola G, Falcao AM, Rodrigues AJ, Geschwind DH, Sousa N, Correia-Neves M, Palha JA: Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation. J Cereb Blood Flow Metab; 2009 May;29(5):921-32
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  • [Title] Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation.
  • The choroid plexus, being part of the blood-brain barriers and responsible for the production of cerebrospinal fluid, is ideally positioned to transmit signals into and out of the brain.
  • This study, using microarray analysis, shows that the mouse choroid plexus displays an acute-phase response after an inflammatory stimulus induced in the periphery by lipopolysaccharide (LPS).
  • Importantly, several acute-phase proteins, whose blood concentrations rise in response to inflammation, may contribute to the effects observed in vivo after LPS injection, as suggested by the differential response of primary choroid plexus epithelial cell cultures to LPS alone or to serum collected from animals exposed to LPS.
  • By modulating the composition of the cerebrospinal fluid, which will ultimately influence the brain parenchyma, the choroid plexus response to inflammation may be of relevance in brain homeostasis in health and disease.
  • [MeSH-major] Acute-Phase Reaction / metabolism. Choroid Plexus / immunology. Choroid Plexus / metabolism. Gene Expression Profiling

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  • (PMID = 19240744.001).
  • [ISSN] 1559-7016
  • [Journal-full-title] Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • [ISO-abbreviation] J. Cereb. Blood Flow Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides
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20. Xu H, Chen M, Forrester JV: Para-inflammation in the aging retina. Prog Retin Eye Res; 2009 Sep;28(5):348-68
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  • With age, para-inflammatory changes have also been observed in the choroidal tissue, evidenced by 1) increased thickness of choroid;.

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  • (PMID = 19560552.001).
  • [ISSN] 1873-1635
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 252
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21. Tokosová E, Uhmannová R, Hlinomazová Z: [Malignant melanoma of the uvea in the Department of Ophthalmology, Faculty Hospital Brno Bohunice, Czech Republic, EU]. Cesk Slov Oftalmol; 2008 Jan;64(1):30-3
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  • PURPOSE: The malignant melanoma of the uvea (MMU) is the most common intraocular tumor among adults.
  • The aim of the retrospective study was to evaluate the stage of the malignant melanoma of the uvea (MMU) at the time of diagnosis in a group of patients, to whom it was diagnosed in the Department of Ophthalmology, Faculty Hospital Brno.
  • METHODS: The group of 19 patients was analyzed in accordance to various criteria: age, sex, location of MMU (iris, ciliary body, and choroid), size of MMU at the time of diagnosis, clinical signs of MMU, methods used in the diagnostic evaluation of the MMU, its treatment, histological type, TNM classification, and metastases.
  • RESULTS: MM of the choroid was diagnosed in 14 cases, MM of the ciliary body in 4 cases and MM of the iris in 1 patient.
  • The patient with MM of the iris was treated by means of therapeutic partial iridectomy and lamelar keratectomy, 5 patients were treated by means of brachytherapy, 3 patients were treated by means of Leksell gama knife and 10 patients underwent the enucleation because of large size of the tumor.
  • At the time of the MMU diagnosis, there were no metastases present in any of the 19 patients.
  • The variety of MMU clinical signs' knowledge may help to the early diagnosis of MMU, which will contribute to the opportunity to use the treatment, which particulary spares the visual functions.
  • [MeSH-major] Melanoma / diagnosis. Uveal Neoplasms / diagnosis

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  • (PMID = 18225497.001).
  • [ISSN] 1211-9059
  • [Journal-full-title] Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
  • [ISO-abbreviation] Cesk Slov Oftalmol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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22. Kopf B, Ercolani D, Zago S, Bucchi E, Rosti G, Marangolo M: Unilateral retinal detachment as the initial sign of lung adenocarcinoma. J Exp Clin Cancer Res; 2007 Mar;26(1):141-3
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  • In patients with lung cancer, uveal metastases, in particular to the choroid, are the most frequent, and are associated mainly with small cell carcinoma or undifferentiated carcinoma.
  • Bronchoscopic biopsies were performed with diagnosis of adenocarcinoma of the lung.
  • [MeSH-major] Adenocarcinoma / secondary. Bone Neoplasms / secondary. Lung Neoplasms / diagnosis. Retinal Detachment / etiology. Retinal Neoplasms / secondary

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  • (PMID = 17550143.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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23. Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T: Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol; 2005;70:283-90
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  • Because the pRb pathway is disrupted in most solid human cancers, we have generated genetically engineered mouse cancer models by inactivating pRb function in several cell types, including astrocytes and mammary, prostate, ovarian, and brain choroid plexus epithelia.
  • Cell type dictates the pathways involved in tumor progression.

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  • (PMID = 16869764.001).
  • [ISSN] 0091-7451
  • [Journal-full-title] Cold Spring Harbor symposia on quantitative biology
  • [ISO-abbreviation] Cold Spring Harb. Symp. Quant. Biol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA46283; United States / NCI NIH HHS / CA / U01-CA84294; United States / NCI NIH HHS / CA / U01-CA84314
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
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24. Torres RJ, Maia M, Noronha L, Farah ME, Luchini A, Brik D, Muccioli C, Précoma DB: [Evaluation of choroid and sclera early alterations in hypercholesterolemic rabbits: histologic and histomorphometric study]. Arq Bras Oftalmol; 2009 Jan-Feb;72(1):68-74
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  • [Title] [Evaluation of choroid and sclera early alterations in hypercholesterolemic rabbits: histologic and histomorphometric study].
  • PURPOSE: To demonstrate experimentally, by means of histological and histomorphometric examinations, the sclera and choroid degenerative alterations, which take place at an early stage due to a hypercholesterolemic diet.
  • RESULTS: The CG presented a mean sclera and choroid thickness of 228.61 +/- 31.71 micrometers in the peripheral region, while the thickness in the posterior region was approximately 246.07 +/- 25.66 micrometers.
  • There was a statistically significant difference in the sclera and choroid thickness between the groups in the peripheral region (p<0.001); however, this difference did not occur in the posterior region (p=0.250).
  • CONCLUSION: This study demonstrated that the hypercholesterolemic diet in rabbits induces a fast increase in the choroid and sclera thickness, mainly due to the increase in the number of histiocytes and collagen fibers.
  • [MeSH-major] Cholesterol, Dietary / adverse effects. Choroid / pathology. Hypercholesterolemia / metabolism. Sclera / pathology

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  • (PMID = 19347126.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Cholesterol, Dietary
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25. Fleming CE, Mar FM, Franquinho F, Sousa MM: Chapter 17: Transthyretin: an enhancer of nerve regeneration. Int Rev Neurobiol; 2009;87:337-46
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  • Transthyretin (TTR), a plasma and cerebrospinal fluid protein secreted by the liver and choroid plexus, is mainly known as the physiological carrier of thyroxine (T(4)) and retinol.
  • Under pathological conditions, various TTR mutations are related to familial amyloid polyneuropathy (FAP), a neurodegenerative disorder characterized by deposition of TTR amyloid fibrils, particularly in the peripheral nervous system (PNS), leading to axonal loss and neuronal death.

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  • (PMID = 19682646.001).
  • [ISSN] 0074-7742
  • [Journal-full-title] International review of neurobiology
  • [ISO-abbreviation] Int. Rev. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prealbumin
  • [Number-of-references] 28
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26. Avdonin PP, Grigorian EN, Markitantova IuV: [Transcriptional factor Pitx2: localization during triton retina regeneration]. Izv Akad Nauk Ser Biol; 2010 May-Jun;(3):283-8
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  • It was demonstrated that protein Pitx2 is expressed not only in retina but also in other tissues of the posterior sector of the eye (pigment epithelium, choroid) using immune-histochemical and Western blot hybridization.

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  • (PMID = 20583611.001).
  • [ISSN] 1026-3470
  • [Journal-full-title] Izvestiia Akademii nauk. Seriia biologicheskaia
  • [ISO-abbreviation] Izv. Akad. Nauk. Ser. Biol.
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Transcription Factors; 184787-43-7 / homeobox protein PITX2
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27. Brinkmann R, Schüle G, Neumann J, Framme C, Pörksen E, Elsner H, Theisen-Kunde D, Roider J, Birngruber R: [Selective retina therapy: methods, technique, and online dosimetry]. Ophthalmologe; 2006 Oct;103(10):839-49
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  • SRT makes it possible to selectively effect the RPE, sparing the adjacent neural retina with the photoreceptors and also the choroid below the RPE.

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  • (PMID = 17003949.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 48
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28. Mitsuhashi S, Yazaki M, Tokuda T, Sekijima Y, Washimi Y, Shimizu Y, Ando Y, Benson MD, Ikeda S: Biochemical characteristics of variant transthyretins causing hereditary leptomeningeal amyloidosis. Amyloid; 2005 Dec;12(4):216-25
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  • The relatively high level of unstable TTR variants in CSF, probably due to increased secretion from the choroid plexus, is considered to be the pathogenesis of the leptomeningeal-type of TTR amyloidosis.
  • [MeSH-minor] Adult. Aged. Choroid Plexus / metabolism. Female. Humans. Male. Middle Aged. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 16399646.001).
  • [ISSN] 1350-6129
  • [Journal-full-title] Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
  • [ISO-abbreviation] Amyloid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prealbumin
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29. Lu F, Zhou X, Jiang L, Fu Y, Lai X, Xie R, Qu J: Axial myopia induced by hyperopic defocus in guinea pigs: A detailed assessment on susceptibility and recovery. Exp Eye Res; 2009 Jun 15;89(1):101-8
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  • The refractive changes during the recovery corresponded to a slower vitreous lengthening and a rapid thickening of the choroid.
  • [MeSH-minor] Animals. Biometry / methods. Choroid / pathology. Disease Models, Animal. Disease Susceptibility. Guinea Pigs. Remission, Spontaneous. Retina / pathology. Tomography, Optical Coherence / methods. Vitreous Body / pathology

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  • (PMID = 19268468.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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30. Berdugo M, Bejjani RA, Valamanesh F, Savoldelli M, Jeanny JC, Blanc D, Ficheux H, Scherz A, Salomon Y, BenEzra D, Behar-Cohen F: Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes. Invest Ophthalmol Vis Sci; 2008 Apr;49(4):1633-44
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  • RESULTS: When occlusive parameters (fluence of 50 J/cm(2), 5 mg/kg drug dose and DLI [distance to light illumination] of 1 minute) were used, Stakel PDT was efficient immediately after treatment without associated structural damage of the RPE and retina overlying the treated choroid in the rabbit eye.
  • [MeSH-minor] Animals. Choroid / drug effects. Drug Evaluation, Preclinical. Fluorescein Angiography. Laser Coagulation. Pigment Epithelium of Eye / drug effects. Pigment Epithelium of Eye / ultrastructure. Porphyrins / therapeutic use. Rabbits. Rats. Rats, Inbred BN. Retina / drug effects. Retina / ultrastructure

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  • (PMID = 18385085.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacteriochlorophylls; 0 / Photosensitizing Agents; 0 / Porphyrins; 0 / WST11 compound; 129497-78-5 / verteporfin
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31. Dejneka NS, Wan S, Bond OS, Kornbrust DJ, Reich SJ: Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes. Mol Vis; 2008;14:997-1005
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  • RESULTS: Following intravitreal injection of 0.5 mg or 2.0 mg radiolabeled bevasiranib to Dutch-Belted rabbits, bevasiranib was detected in the vitreous, iris, retina, retinal pigment epithelium (RPE), and sclera (+choroid).

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  • (PMID = 18523657.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Vasconcellos LP, Santos AR, Veiga JC, Schilemann I, Lancellotti CL: Supratentorial intraventricular schwannoma of the choroid plexus. Arq Neuropsiquiatr; 2009 Dec;67(4):1100-2
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  • [Title] Supratentorial intraventricular schwannoma of the choroid plexus.
  • [MeSH-major] Choroid Plexus Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 20069228.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Brazil
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33. Buckle C, Smith JK: Choroid plexus papilloma of the third ventricle. Pediatr Radiol; 2007 Jul;37(7):725
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  • [Title] Choroid plexus papilloma of the third ventricle.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Magnetic Resonance Imaging. Papilloma, Choroid Plexus / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 17464502.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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34. Amorosi S, D'Armiento M, Calcagno G, Russo I, Adriani M, Christiano AM, Weiner L, Brissette JL, Pignata C: FOXN1 homozygous mutation associated with anencephaly and severe neural tube defect in human athymic Nude/SCID fetus. Clin Genet; 2008 Apr;73(4):380-4
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  • Moreover, we found that FOXN1 gene is expressed in mouse developing choroid plexus.


35. Tappeiner C, Dohrmann J, Spital G, Heiligenhaus A: Multifocal posterior uveitis in Crohn's disease. Graefes Arch Clin Exp Ophthalmol; 2007 Mar;245(3):457-9
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  • RESULTS: The perimetry revealed absolute and relative scotomas corresponding to multifocal inflammatory lesions in the retina and choroid, reduced a/b amplitudes in multifocal-ERG and hypofluorescent dots in angiography.
  • CONCLUSION: Multifocal inflammatory lesions in the retina and choroid in patients with Crohn's disease may occur and may precede a recurrent intestinal episode.

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  • (PMID = 16788825.001).
  • [ISSN] 0721-832X
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36. Tian J, Ishibashi K, Ishibashi K, Reiser K, Grebe R, Biswal S, Gehlbach P, Handa JT: Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response. Proc Natl Acad Sci U S A; 2005 Aug 16;102(33):11846-51
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  • [Title] Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response.
  • Although AGE fluorescence was increased in D-gal-treated retinal pigment epithelium (RPE)-choroid compared with controls at all time points, ERG showed no AGE-induced functional toxicity.
  • Progressive ultrastructural aging in the RPE-choroid was associated temporally with a transcriptional response of early inflammation, matrix expansion, and aberrant lipid processing and, later, down-regulation of energy metabolism genes, up-regulation of crystallin genes, and altered expression of cell structure genes.
  • [MeSH-major] Cell Aging / physiology. Choroid / metabolism. Glycosylation End Products, Advanced / metabolism. Pigment Epithelium of Eye / metabolism. Transcription, Genetic / genetics

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  • (PMID = 16081535.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY014005; United States / NEI NIH HHS / EY / EY 14055; United States / NEI NIH HHS / EY / EY134020-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycosylation End Products, Advanced; 0 / RNA, Messenger; X2RN3Q8DNE / Galactose
  • [Other-IDs] NLM/ PMC1182551
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37. Niimi M, Tao L, Lin SH, Yin J, Wu X, Fukui H, Kambayashi J, Ye J, Sun B: Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells. J Biomed Sci; 2009;16:92
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  • However, ODC-AS was only detected in adipose tissue and in iris and sclera-choroid complex of the eye.

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  • (PMID = 19825180.001).
  • [ISSN] 1423-0127
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carboxylic Acids; 0 / Lipids; 0 / Mitochondrial Membrane Transport Proteins; 0 / Organic Anion Transporters
  • [Other-IDs] NLM/ PMC2765418
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38. Tohmi M, Tsuda N, Zheng Y, Mizuno M, Sotoyama H, Shibuya M, Kawamura M, Kakita A, Takahashi H, Nawa H: The cellular and behavioral consequences of interleukin-1 alpha penetration through the blood-brain barrier of neonatal rats: a critical period for efficacy. Neuroscience; 2007 Nov 30;150(1):234-50
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  • Following s.c. injection of IL-1 alpha into rat neonates, IL-1 alpha immunoreactivity was first detected in the choroid plexus, brain microvessels, and olfactory cortex, and later diffused to many brain regions such as neocortex and hippocampus.

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  • (PMID = 17964733.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-1alpha; 0 / Nerve Tissue Proteins
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39. Shi X, Semkova I, Müther PS, Dell S, Kociok N, Joussen AM: Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Exp Eye Res; 2006 Dec;83(6):1325-34
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  • Western blotting demonstrated that TNF-alpha expression was 4.57-fold higher in the choroid and RPE one week after laser injury compared to control mice without laser.
  • [MeSH-major] Choroidal Neovascularization / prevention & control. Laser Coagulation / adverse effects. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Animals. Antibodies, Monoclonal / therapeutic use. Blotting, Western / methods. Choroid / metabolism. Etanercept. Immunoglobulin G / therapeutic use. Infliximab. Mice. Mice, Inbred C57BL. Pigment Epithelium of Eye / metabolism. Receptors, Tumor Necrosis Factor / therapeutic use

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  • (PMID = 16959248.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab; OP401G7OJC / Etanercept
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40. Chen Y, Burnes DL, de Bruin M, Mujat M, de Boer JF: Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging. J Biomed Opt; 2009 Mar-Apr;14(2):024016
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  • The relative scattering intensities from different layers such as the nerve fiber, photoreceptor, pigment epithelium, and choroid are measured and a quantitative comparison is presented.

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  • (PMID = 19405746.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01-EY014975; United States / NCRR NIH HHS / RR / R01-RR019768
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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41. Subramanian L, Tole S: Mechanisms underlying the specification, positional regulation, and function of the cortical hem. Cereb Cortex; 2009 Jul;19 Suppl 1:i90-5
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  • The cortical hem was first described as a potential signaling center at the telencephalic midline because of an enriched expression of multiple members of the Wnt and Bmp families of morphogens, and its position at the border between the presumptive cortex and the choroid plexus.

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  • (PMID = 19359348.001).
  • [ISSN] 1460-2199
  • [Journal-full-title] Cerebral cortex (New York, N.Y. : 1991)
  • [ISO-abbreviation] Cereb. Cortex
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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42. Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tchibana T, Kiyama H, Fukumura T, Kim DH, Saeki S: Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family. Biochem Biophys Res Commun; 2010 Jan 1;391(1):1110-5
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  • In situ hybridization of the rat brain showed that the transcripts were intensely present in the cerebral cortex, hippocampus, choroid plexus, ependyma and granular layer.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 20005200.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LDL-Receptor Related Proteins; 0 / LRP10 protein, human
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43. Meyza KZ, Sotowska-Brochocka J: Photoperiod affects distribution of dynorphin A in the brain of Siberian hamster. Acta Neurobiol Exp (Wars); 2006;66(3):207-13
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  • Structures of the hypothalamo-pituitary axis as well as cells of the ependyma, subcomissural organ and choroid plexus of the lateral and third brain ventricles are immunoreactive to anti-dynorphin IgG only in the LD.

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  • (PMID = 17133952.001).
  • [ISSN] 0065-1400
  • [Journal-full-title] Acta neurobiologiae experimentalis
  • [ISO-abbreviation] Acta Neurobiol Exp (Wars)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 74913-18-1 / Dynorphins
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44. Gibbs JE, Gaffen Z, Thomas SA: Nevirapine uptake into the central nervous system of the Guinea pig: an in situ brain perfusion study. J Pharmacol Exp Ther; 2006 May;317(2):746-51
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  • [(3)H]Nevirapine was coperfused with [(14)C]mannitol (a vascular/paracellular permeability marker) through the carotid arteries for up to 30 min, and accumulation in the brain, CSF, and choroid plexus was measured.

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  • (PMID = 16424147.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 073542; United Kingdom / Wellcome Trust / / RCDF 057254
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 99DK7FVK1H / Nevirapine
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45. Wax JR, Cartin A, Pinette MG, Blackstone J: Does the frequency of soft sonographic aneuploidy markers vary by fetal sex? J Ultrasound Med; 2005 Aug;24(8):1059-63
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  • Markers studied were biparietal diameter/femur length, transcerebellar diameter, ear length, echogenic bowel, femur length, humerus length, absent middle fifth phalanx, nuchal fold, renal pelvis dilatation, echogenic cardiac focus, and choroid plexus cysts.

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  • (PMID = 16040819.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Moriyama M, Ohno-Matsui K, Futagami S, Yoshida T, Hayashi K, Shimada N, Kojima A, Tokoro T, Mochizuki M: Morphology and long-term changes of choroidal vascular structure in highly myopic eyes with and without posterior staphyloma. Ophthalmology; 2007 Sep;114(9):1755-62
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  • A displacement of the entry site of the posterior ciliary arteries into the choroid was observed in 76.6% of the eyes with posterior staphyloma and in 25.3% of the eyes without (P<0.001).
  • [MeSH-major] Choroid / blood supply. Choroid Diseases / diagnosis. Choroid Diseases / etiology. Myopia, Degenerative / complications

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  • (PMID = 17368542.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; IX6J1063HV / Indocyanine Green
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47. Tseng KY, Ma HI, Hueng DY, Lin JH: Cavum septum pellucidum: a feasible route to third ventricle. Neurol India; 2010 Nov-Dec;58(6):942-4
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  • We report a patient with choroid glioma in the anterior part of the third ventricle, and coincident cavum septum pellucidum (CSP) in whom we could remove the tumor gross totally without damaging any neurovascular structures.
  • The tumor expanded the space between the rostrum of the corpus callosum and the column of the fornix and lifted up the floor of CSP.
  • The transcavum-septum-pellucidum approach anterior to foramen of Monro was chosen to remove the anterior third ventricle tumor.
  • We propose that the tumor had likely expanded within the above-mentioned space and elevated the floor of CSP thus increasing the anteroposterior diameter of the floor providing a feasible avenue to third ventricle making it feasible to pass through the enlarged space safely.
  • [MeSH-major] Choroid Neoplasms / surgery. Glioma / surgery. Septum Pellucidum / surgery. Third Ventricle / surgery

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  • (PMID = 21150064.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
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48. Maloney SC, Godeiro KD, Odashiro AN, Burnier MN Jr: Current and emerging concepts in the management of neovascular age-related macular degeneration. Cardiovasc Hematol Agents Med Chem; 2007 Apr;5(2):147-54
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  • The more severe form of the disease, known as neovascular AMD, is characterized by aberrant growth of blood vessels from the choroid into the subretinal space.

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  • (PMID = 17430137.001).
  • [ISSN] 1871-5257
  • [Journal-full-title] Cardiovascular & hematological agents in medicinal chemistry
  • [ISO-abbreviation] Cardiovasc Hematol Agents Med Chem
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Anti-Inflammatory Agents; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
  • [Number-of-references] 142
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49. Bastianetto S, Brouillette J, Quirion R: Neuroprotective effects of natural products: interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin. Neurochem Res; 2007 Oct;32(10):1720-5
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  • Interestingly, the choroid plexus secretes transthyretin, a protein that has been shown to prevent Abeta aggregation and that may be critical to the maintenance of normal learning capacities in aging.

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  • (PMID = 17406978.001).
  • [ISSN] 0364-3190
  • [Journal-full-title] Neurochemical research
  • [ISO-abbreviation] Neurochem. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid beta-Peptides; 0 / Antioxidants; 0 / Biological Products; 0 / Flavonoids; 0 / Neuroprotective Agents; 0 / Peptides; 0 / Phenols; 0 / Polyphenols; 0 / Prealbumin; 0 / Stilbenes; 5688UTC01R / Tretinoin; 8R1V1STN48 / Catechin; EC 2.7.- / Phosphotransferases; Q369O8926L / resveratrol
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50. Deyts C, Casane D, Vernier P, Bourrat F, Joly JS: Morphological and gene expression similarities suggest that the ascidian neural gland may be osmoregulatory and homologous to vertebrate peri-ventricular organs. Eur J Neurosci; 2006 Oct;24(8):2299-308
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  • We further speculate about the potential similarities between the ascidian NGC and the vertebrate choroid plexus, a neural peri-ventricular organ.

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  • (PMID = 17074050.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Angiotensin; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Somatostatin; 0 / Receptors, Tachykinin; 0 / Receptors, Vasopressin; 63231-63-0 / RNA; 9015-71-8 / Corticotropin-Releasing Hormone
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51. Aicardi J: Aicardi syndrome. Brain Dev; 2005 Apr;27(3):164-71
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  • The brain malformation is complex with cortical migration abnormalities, often cystic formations and sometimes choroid plexus papillomas; the eye anomalies, often feature a coloboma in addition to the lacunae, and focal seizures rather than spasms, are common.
  • [MeSH-major] Choroid Diseases. Corpus Callosum. Retinal Diseases. Spasms, Infantile


52. Stefanović I, Dacić B, Novak S, Veselinović D, Jovanović P, Dzunić B, Tomasević B: [Topographic localization of an intraocular foreign body by B-scan echography]. Vojnosanit Pregl; 2010 Mar;67(3):213-5
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  • The aim of this study was to retrospectively analyze echographic findings in patients with the diagnosis of intraocular foreign body with a special interest in localizations of a intraocular foreign body in the eye and the presence of an eventual infection - endophthalmitis.
  • In 7 injured eyes (25.9%), with the presence of intraocular foreign body, we found signs of endophthalmitis (organized blurring in vitreal space, thickened choroid).

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  • (PMID = 20361695.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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53. Beke A, Papp C, Tóth-Pál E, Mezei G, Joó JG, Csaba A, Papp Z: Trisomies and other chromosome abnormalities detected after positive sonographic findings. J Reprod Med; 2005 Sep;50(9):675-91
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  • The incidence of chromosome abnormalities in cases of cerebral anomalies was 6.3% of cases with ventricular dilatation, 3.6% of cases with choroid plexus cysts and 15.9% of cases with other cranial anomalies.
  • CONCLUSION: Ultrasound plays an important role in prenatal diagnosis.
  • [MeSH-major] Chromosome Aberrations. Chromosome Disorders / ultrasonography. Fetal Diseases / ultrasonography. Prenatal Diagnosis

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  • (PMID = 16363756.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Kläs J, Wolburg H, Terasaki T, Fricker G, Reichel V: Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier. Cerebrospinal Fluid Res; 2010;7:11
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  • [Title] Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier.
  • BACKGROUND: Two rodent choroid plexus (CP) epithelial cell lines, Z310 and TR-CSFB, were compared with primary rat CP epithelial cells and intact CP tissue with respect to transport protein expression, function and tight junction (TJ) formation.

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  • (PMID = 20704740.001).
  • [ISSN] 1743-8454
  • [Journal-full-title] Cerebrospinal fluid research
  • [ISO-abbreviation] Cerebrospinal Fluid Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2927495
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55. Motley WW 3rd, Augsburger JJ, Hutchins RK, Schneider S, Boat TF: Pseudomonas aeruginosa endogenous endophthalmitis with choroidal abscess in a patient with cystic fibrosis. Retina; 2005 Feb-Mar;25(2):202-7
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  • RESULTS: Diagnosis was confirmed by culture of purulent fluid obtained by transcleral incision and drainage.
  • The infection persisted in spite of aggressive surgical intervention including extensive endoresection of the visibly affected retina and choroid and multiple administrations of appropriate intraocular, subconjunctival, and systemic antibiotics.
  • [MeSH-major] Abscess / microbiology. Choroid Diseases / microbiology. Cystic Fibrosis / microbiology. Endophthalmitis / microbiology. Eye Infections, Bacterial / microbiology. Pseudomonas Infections / microbiology. Pseudomonas aeruginosa / isolation & purification


56. Kodama M, Kawaguchi H, Komoto Y, Takemura M: Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer. J Obstet Gynaecol Res; 2010 Feb;36(1):199-203
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  • Involvement of intramedullary spinal cord and the choroid by ovarian cancer is rare, and coexistence of metastases at these sites is extremely rare and has never been reported.
  • She presented with blindness and other neurologic complaints during the course of treatment for a recurrence at 50 months after the primary surgical treatment for the tumor.
  • Early diagnosis and multidisciplinary treatment, including radiotherapy and chemotherapy, may offer good palliation for such unusual metastases of ovarian cancer.
  • [MeSH-major] Brain Neoplasms / secondary. Choroid Neoplasms / secondary. Cystadenocarcinoma, Serous / secondary. Neoplasm Recurrence, Local. Ovarian Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 20178552.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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57. Woo SJ, Kim JH, Yu HG: Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. J Ocul Pharmacol Ther; 2010 Jun;26(3):223-9
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  • CNV lesion dimensions including CNV area and CNV/choroid thickness ratio were also significantly reduced in the UDCA and TUDCA groups (7,664 +/- 630 microm(2), P < 0.001 and 8,558 +/- 570 microm(2), P < 0.001; 2.35 +/- 0.16, P = 0.026 and 2.27 +/- 0.15, P = 0.003) compared with the control group (12,147 +/- 661 microm(2) and 3.10 +/- 0.27).

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  • (PMID = 20565307.001).
  • [ISSN] 1557-7732
  • [Journal-full-title] Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • [ISO-abbreviation] J Ocul Pharmacol Ther
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Vascular Endothelial Growth Factor A; 516-35-8 / Taurochenodeoxycholic Acid; 60EUX8MN5X / tauroursodeoxycholic acid; 67XQY1V3KH / Argon; 724L30Y2QR / Ursodeoxycholic Acid
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58. Behl M, Zhang Y, Zheng W: Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure. Cerebrospinal Fluid Res; 2009 Sep 11;6:11
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  • Previous work from this laboratory demonstrated that the choroid plexus (CP) possesses the capacity to remove Abeta from the cerebrospinal fluid (CSF), and exposure to lead (Pb) compromises this function.

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  • (PMID = 19747378.001).
  • [ISSN] 1743-8454
  • [Journal-full-title] Cerebrospinal fluid research
  • [ISO-abbreviation] Cerebrospinal Fluid Res
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES008146; United States / NIEHS NIH HHS / ES / R21 ES017055; United States / NIEHS NIH HHS / ES / R56 ES008146
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2753621
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59. Norose K, Aosai F, Mun HS, Yano A: Effects of sulfamethoxazole on murine ocular toxoplasmosis in interferon-gamma knockout mice. Invest Ophthalmol Vis Sci; 2006 Jan;47(1):265-71
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  • In GKO C57BL/6 G3 mice, T. gondii DNA was detected in the brain, optic nerve, and retina, but not in the iris, choroid, sclera, and blood.

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  • (PMID = 16384972.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / DNA, Protozoan; 82115-62-6 / Interferon-gamma; JE42381TNV / Sulfamethoxazole
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60. Gillingham MB, Weleber RG, Neuringer M, Connor WE, Mills M, van Calcar S, Ver Hoeve J, Wolff J, Harding CO: Effect of optimal dietary therapy upon visual function in children with long-chain 3-hydroxyacyl CoA dehydrogenase and trifunctional protein deficiency. Mol Genet Metab; 2005 Sep-Oct;86(1-2):124-33
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  • Eleven subjects who were homozygote and heterozygote for the common mutation, c.1528G>C, had no change to severe progression of atrophy of the choroid and retina with time.

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  • [ISSN] 1096-7192
  • [Journal-full-title] Molecular genetics and metabolism
  • [ISO-abbreviation] Mol. Genet. Metab.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01 RR00334; United States / NCRR NIH HHS / RR / M01 RR000334-36S20613; United States / NCRR NIH HHS / RR / RR000334-360613; United States / NCRR NIH HHS / RR / M01 RR000334-340613; United States / NCRR NIH HHS / RR / RR000334-350613; United States / NCRR NIH HHS / RR / M01 RR003186-160251; United States / NCRR NIH HHS / RR / M01 RR000334-380613; United States / NCRR NIH HHS / RR / M01 RR003186; United States / NCRR NIH HHS / RR / M01 RR003186-130251; United States / NCRR NIH HHS / RR / M01 RR003186-150251; United States / NCRR NIH HHS / RR / M01 RR000334; United States / NCRR NIH HHS / RR / RR003186-15S30251; United States / NCRR NIH HHS / RR / M01 RR003186-15S30251; United States / NCRR NIH HHS / RR / RR000334-35S10613; United States / NCRR NIH HHS / RR / RR03186; United States / NCRR NIH HHS / RR / RR003186-150251; United States / NCRR NIH HHS / RR / M01 RR000334-35S10613; United States / NCRR NIH HHS / RR / RR000334-390613; United States / NCRR NIH HHS / RR / RR000334-36S20613; United States / NIGMS NIH HHS / GM / T32 GM008796; United States / NCRR NIH HHS / RR / M01 RR003186-140251; United States / NCRR NIH HHS / RR / M01 RR000334-350613; United States / NCRR NIH HHS / RR / RR000334-380613; United States / NCRR NIH HHS / RR / RR003186-140251; United States / NCRR NIH HHS / RR / M01 RR000334-360613; United States / NCRR NIH HHS / RR / RR003186-160251; United States / NCRR NIH HHS / RR / M01 RR000334-390613; United States / NCRR NIH HHS / RR / RR000334-340613; United States / NIGMS NIH HHS / GM / T32GM08976; United States / NCRR NIH HHS / RR / RR003186-130251
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids; EC 1.1.1.- / 3-Hydroxyacyl CoA Dehydrogenases; EC 1.1.1.211 / Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase
  • [Other-IDs] NLM/ NIHMS110388; NLM/ PMC2694051
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61. Guo Y, Jiang L: Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. Neurol Res; 2010 Feb;32(1):106-12
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  • In the brain, Oatp2 and P-gp immunopositive cells were observed in brain capillary endothelium and choroid plexus epithelium.
  • [MeSH-minor] Animals. Choroid Plexus / metabolism. Chronic Disease. Endothelial Cells / metabolism. Female. Lithium. Male. Pilocarpine. RNA, Messenger / metabolism. Rats. Rats, Wistar. Status Epilepticus / chemically induced. Status Epilepticus / metabolism

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  • (PMID = 19570321.001).
  • [ISSN] 1743-1328
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / P-Glycoprotein; 0 / RNA, Messenger; 0 / Slco1a4 protein, rat; 01MI4Q9DI3 / Pilocarpine; 9FN79X2M3F / Lithium
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62. Howden L, Giddings D, Power H, Aroussi A, Vloeberghs M, Garnett M, Walker D: Three-dimensional cerebrospinal fluid flow within the human ventricular system. Comput Methods Biomech Biomed Engin; 2008 Apr;11(2):123-33
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  • During this investigation CSF flow rate was set at a constant 500 ml/day, to mimic real life secretion of CSF into the system, and a pulsing velocity profile was added to the inlets to incorporate the effect of cardiac pulsations on the choroid plexus and their subsequent influence on CSF motion in the Hvs. Boundary conditions for the CSF exits from the ventricles (foramina of Magendie and Lushka) were found using a "nesting" approach, in which a simplified model of the entire central nervous system (CNS) was used to examine the effects of the CSF surrounding the ventricular system (VS).

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  • (PMID = 18297492.001).
  • [ISSN] 1025-5842
  • [Journal-full-title] Computer methods in biomechanics and biomedical engineering
  • [ISO-abbreviation] Comput Methods Biomech Biomed Engin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Studnicka J, Rencová E, Korda V, Hejcmanová D, Dusová J, Kvasnicka J: [Transpupillary thermotherapy in the treatment of choroidal neovascularization in age-related macular degeneration--one year's results]. Cesk Slov Oftalmol; 2006 May;62(3):190-9
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  • CONCLUSION: Our results show that transpupillary themotherapy belongs to important methods of treatment of the classical and occult membranes of the choroid in exsudative forms of the ARMD.

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  • (PMID = 16758759.001).
  • [ISSN] 1211-9059
  • [Journal-full-title] Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
  • [ISO-abbreviation] Cesk Slov Oftalmol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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64. Weichel ED, Bower KS, Colyer MH: Chorioretinectomy for perforating or severe intraocular foreign body injuries. Graefes Arch Clin Exp Ophthalmol; 2010 Mar;248(3):319-30
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  • BACKGROUND: To report the outcomes of chorioretinectomy versus non-chorioretinectomy in combat ocular injuries where a foreign body penetrated the choroid or perforated the globe.
  • The chorioretinectomy group was repaired with a 20 gauge three-port pars plana vitrectomy (PPV) by removing the choroid and/or retina at the impact or perforation site of the foreign body following evacuation from a combat zone.
  • CONCLUSION: Chorioretinectomy is a surgical option that may improve final BCVA and increase globe survival rates when a foreign body penetrates the choroid or perforates the globe.
  • [MeSH-major] Choroid / surgery. Eye Foreign Bodies / surgery. Eye Injuries, Penetrating / surgery. Military Personnel. Ophthalmologic Surgical Procedures. Retina / surgery

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  • (PMID = 20155279.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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65. Tovar MO, Obando MJ, Gómez E, Caldas ML, Hurtado H: [Histology and morphometry of the in the freshwater Paracheirodon axelrodi (Characiformes: Characidae)]. Rev Biol Trop; 2009 Dec;57(4):1107-18
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  • Rete mirabilis choroid was composed mainly by capillaries, while sclera was composed of cartilaginous tissue.
  • Cornea thickness was 27.6 microm (SD = 4.3, n = 20); iris thickness was 18.9 microm (SD = 1.9, n = 20); rete mirabilis choroid 22.2 microm (SD = 3.2, n = 20) and sclera: 15.9 microm (SD = 1.2, n = 20).

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  • (PMID = 20073338.001).
  • [ISSN] 0034-7744
  • [Journal-full-title] Revista de biología tropical
  • [ISO-abbreviation] Rev. Biol. Trop.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Costa Rica
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66. Kim IK, Husain D, Michaud N, Connolly E, Lane AM, Durrani K, Hafezi-Moghadam A, Gragoudas ES, O'Neill CA, Beyer JC, Miller JW: Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid. Invest Ophthalmol Vis Sci; 2006 Jan;47(1):357-63
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  • [Title] Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid.
  • San Francisco, CA) directed against vascular endothelial growth factor (VEGF) in combination with verteporfin photodynamic therapy (PDT) on normal primate retina and choroid.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Choroid / drug effects. Photochemotherapy. Photosensitizing Agents / pharmacology. Porphyrins / pharmacology. Retina / drug effects

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  • (PMID = 16384985.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin; ZL1R02VT79 / Ranibizumab
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67. Komuro T, Okamoto S: Pure intracerebral mass lesion of adult T-cell leukemia/lymphoma--case report. Neurol Med Chir (Tokyo); 2010;50(6):492-4
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  • Laboratory examination showed transient leukocytosis (15900/microl) without febrile episode or elevation of C-reactive protein.
  • Neuroimaging revealed a solitary enhanced mass lesion in the right occipital lobe adjacent to the choroid plexus with prominent perifocal edema.
  • The patient underwent gross total removal, and the histological diagnosis was intracerebral ATL.
  • Intracerebral ATL should be considered in the differential diagnosis of intracerebral mass without leukemia or systemic lymphoma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Leukemia-Lymphoma, Adult T-Cell / diagnosis. Occipital Lobe / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Treatment Outcome

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  • (PMID = 20587977.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Lujan BJ, Rosenfeld PJ, Gregori G, Wang F, Knighton RW, Feuer WJ, Puliafito CA: Spectral domain optical coherence tomographic imaging of geographic atrophy. Ophthalmic Surg Lasers Imaging; 2009 Mar-Apr;40(2):96-101
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  • RESULTS: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid.
  • [MeSH-major] Macular Degeneration / diagnosis. Retinal Pigment Epithelium / pathology. Tomography, Optical Coherence

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  • (PMID = 19320296.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY014801; United States / NEI NIH HHS / EY / R03 EY016420
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Forooghian F, Yeh S, Faia LJ, Nussenblatt RB: Uveitic foveal atrophy: clinical features and associations. Arch Ophthalmol; 2009 Feb;127(2):179-86
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  • Clinical findings associated with foveal atrophy included atrophy of the retinal pigment epithelium and choroid (30 eyes [91%]), macular ischemia (13 eyes [39%]), cystoid macular edema (5 eyes [15%]), choroidal neovascularization (4 eyes [12%]), retinal detachment involving the macula (2 eyes [6%]), and serum antiretinal antibodies (2 eyes [6%]).
  • The cause of foveal atrophy is multifactorial and may include dysfunction and atrophy of the retinal pigment epithelium and choroid, cystoid macular edema, macular ischemia secondary to occlusive retinal vasculitis, choroidal neovascularization, retinal detachment, and possibly antibody-mediated damage directed against photoreceptors.
  • [MeSH-major] Fovea Centralis / pathology. Panuveitis / complications. Retinal Diseases / diagnosis. Retinal Diseases / etiology. Uveitis, Intermediate / complications. Uveitis, Posterior / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Atrophy / diagnosis. Atrophy / etiology. Choroid / pathology. Cross-Sectional Studies. Female. Fluorescein Angiography. Humans. Male. Middle Aged. Photoreceptor Cells, Vertebrate / pathology. Retinal Pigment Epithelium / pathology. Retrospective Studies. Tomography, Optical Coherence. Vision Disorders / diagnosis. Vision Disorders / etiology. Visual Acuity

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  • (PMID = 19204236.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 EY000356-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS62160; NLM/ PMC2653214
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70. Kuriyama F, Ueda Y, Araki M: Complete reconstruction of the retinal laminar structure from a cultured retinal pigment epithelium is triggered by altered tissue interaction and promoted by overlaid extracellular matrices. Dev Neurobiol; 2009 Dec;69(14):950-8
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  • We cultured a Xenopus RPE monolayer sheet isolated from the choroid on a filter cup with gels overlaid and found that the retinal tissue structure differentiated with all retinal layers present.
  • In contrast, when RPE monolayers were cultured similarly without isolation from the choroid, RPE cells proliferated, but remained pigmented instead of transdifferentiating, indicating that alteration in tissue interaction triggers transdifferentiation.
  • We then examined under the conventional tissue culture condition whether altered RPE-choroid interaction induces Pax6 expression.
  • Pax6 was upregulated in RPE cells soon after they were removed from the choroid, and this expression was not dependent of FGF2.
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Proliferation. Cell Transdifferentiation / physiology. Choroid / cytology. Choroid / metabolism. Eye Proteins / metabolism. Fibroblast Growth Factor 2 / metabolism. Fluorescent Antibody Technique. Homeodomain Proteins / metabolism. Organ Culture Techniques. Paired Box Transcription Factors / metabolism. Repressor Proteins / metabolism. Xenopus Proteins / metabolism. Xenopus laevis

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  • (PMID = 19701886.001).
  • [ISSN] 1932-846X
  • [Journal-full-title] Developmental neurobiology
  • [ISO-abbreviation] Dev Neurobiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Homeodomain Proteins; 0 / PAX6 protein; 0 / Paired Box Transcription Factors; 0 / Repressor Proteins; 0 / Xenopus Proteins; 103107-01-3 / Fibroblast Growth Factor 2
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71. Miyagi Y, Natori Y, Suzuki SO, Iwaki T, Morioka T, Arimura K, Maeda Y, Shono T, Matsukado K, Sasaki T: Purely cystic form of choroid plexus papilloma with acute hydrocephalus in an infant. Case report. J Neurosurg; 2006 Dec;105(6 Suppl):480-4
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  • [Title] Purely cystic form of choroid plexus papilloma with acute hydrocephalus in an infant. Case report.
  • Infants with acute hydrocephalus often present with nonspecific neurological signs, and cystic choroid plexus papilloma (CPP) is a very rare cause of acute obstructive hydrocephalus.
  • Endoscopic examination revealed a highly mobile cyst attached by a pedicle to the choroid plexus adjacent to the Monro foramen in the lateral ventricle.
  • Purely cystic CPP is a very rare pathological entity; however, when it does occur, it can cause obstructive hydrocephalus which, without rapid diagnosis and surgical intervention, could lead to sudden death.
  • [MeSH-major] Hydrocephalus / etiology. Hydrocephalus / pathology. Papilloma, Choroid Plexus / complications. Papilloma, Choroid Plexus / pathology


72. Brassesco MS, Valera ET, Neder L, Castro-Gamero AM, Arruda D, Machado HR, Sakamoto-Hojo ET, Tone LG: Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa. Neuropathology; 2009 Jun;29(3):293-8
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  • [Title] Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa.
  • Cytogenetic studies of choroid plexus tumors, particularly for atypical choroid plexus papillomas, have been rarely described.
  • In the present report, the cytogenetic investigation of an atypical choroid plexus papilloma occurring at the posterior fossa of a 16-year-old male is described.
  • Furthermore, the microscopic analysis of cultures showed nuclear buds, nucleoplasmic bridges, and micronuclei in 23% of tumor cells suggesting the presence of complex chromosomal abnormalities.
  • Previous cytogenetic studies on choroid plexus papillomas showed either normal, hypodiploid or hyperdiploid karyotypes.
  • To the best of our knowledge, this is the first report of polyploidy in choroid plexus papilloma of intermediate malignancy grade.
  • Although the mechanisms beneath such genome duplication remain to be elucidated, the observed abnormal nuclear shapes indicate constant restructuring of the tumor's genome and deserves further investigation.
  • [MeSH-major] Infratentorial Neoplasms / genetics. Papilloma, Choroid Plexus / genetics. Polyploidy
  • [MeSH-minor] Adolescent. Cell Nucleus / genetics. Cell Nucleus / pathology. Cell Nucleus Shape. Centromere / pathology. Chromosome Aberrations. Comparative Genomic Hybridization. Humans. In Situ Hybridization, Fluorescence. Male. Neoplasm Staging

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  • (PMID = 18627486.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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73. Yuan X, Gu X, Crabb JS, Yue X, Shadrach K, Hollyfield JG, Crabb JW: Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes. Mol Cell Proteomics; 2010 Jun;9(6):1031-46
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  • [Title] Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes.
  • A quantitative proteomics analysis of the macular Bruch membrane/choroid complex was pursued for insights into the molecular mechanisms of age-related macular degeneration (AMD).

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  • (PMID = 20177130.001).
  • [ISSN] 1535-9484
  • [Journal-full-title] Molecular & cellular proteomics : MCP
  • [ISO-abbreviation] Mol. Cell Proteomics
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R56 EY014240; United States / NEI NIH HHS / EY / R01 EY014240; United States / NEI NIH HHS / EY / EY15638; United States / NEI NIH HHS / EY / EY14240; United States / NEI NIH HHS / EY / R01 EY014239; United States / NEI NIH HHS / EY / R24 EY015638; United States / NEI NIH HHS / EY / EY14239
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Proteome
  • [Other-IDs] NLM/ PMC2877969
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74. Levine JP, Freund KB, Cooney MJ, Klancnik JM Jr, Shirkey BL, Yannuzzi LA: Multifocal choroiditis in siblings. Retin Cases Brief Rep; 2008;2(2):151-3
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  • DISCUSSION: Multifocal choroiditis is an inflammatory disorder of the inner choroid and retinal pigment epithelium of unknown etiology.

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  • (PMID = 25389829.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Wind JJ, Bell RS, Bank WO, Myseros JS: Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone. J Neurosurg Pediatr; 2010 Dec;6(6):579-82
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  • [Title] Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone.
  • The authors present the case of a 3-month-old boy with a third ventricular tumor consistent with a choroid plexus papilloma.
  • Due to the vascular nature of these tumors and the age of this child, the tumor was embolized with a plan for eventual resection; however, embolization resulted in involution and total regression of the tumor.
  • In this specific scenario of a choroid plexus papilloma in an infant, when operative intervention may be technically difficult and associated with significant morbidity, embolization with close observation may be a valid treatment option.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Embolization, Therapeutic. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / therapy. Third Ventricle / pathology

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  • (PMID = 21121734.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Zhang L, Leung YF: Microdissection of zebrafish embryonic eye tissues. J Vis Exp; 2010;(40)
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  • A careful lifting action of this tissue can efficiently separate the presumptive choroid and sclera.
  • [MeSH-minor] Animals. Choroid / surgery. Lens, Crystalline / surgery. Models, Animal. Sclera / surgery

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77. Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessl A, Szurman P, Wolfrum U, Wijnholds J, Fischer MD, Humphries P, Seeliger MW: Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol; 2010 Aug;248(8):1063-70
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  • Also, the vascular endothelium developed fenestrations similar to the RPE-choroid interface.

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  • [ErratumIn] Graefes Arch Clin Exp Ophthalmol. 2010 Sep;248(9):1365. Fisher, M D [corrected to Fischer, M D]
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  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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78. Booij JC, Baas DC, Beisekeeva J, Gorgels TG, Bergen AA: The dynamic nature of Bruch's membrane. Prog Retin Eye Res; 2010 Jan;29(1):1-18
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  • Finally, we attempt to correlate recently published mRNA expression profiles of the RPE and choroid with molecular, structural and functional properties of BM.

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  • (PMID = 19747980.001).
  • [ISSN] 1873-1635
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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79. Girardin F: Membrane transporter proteins: a challenge for CNS drug development. Dialogues Clin Neurosci; 2006;8(3):311-21
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  • The lack of capillary fenestration, the low pinocytic activity and the tight junctions between brain capillary and choroid plexus endothelial cells represent further gatekeepers limiting the entrance of endogenous and exogenous compounds into the central nervous system.
  • Drug transport is a result of the concerted action of efflux and influx pumps (transporters) located both in the basolateral and apical membranes of brain capillary and choroid plexus endothelial cells.
  • They are ATP-independent polypeptides principally expressed at the basolateral membrane of brain capillary and choroid plexus endothelial cells that also mediate drug transport through central nervous system barriers.

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  • (PMID = 17117613.001).
  • [ISSN] 1294-8322
  • [Journal-full-title] Dialogues in clinical neuroscience
  • [ISO-abbreviation] Dialogues Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Central Nervous System Agents; 0 / Membrane Transport Proteins
  • [Number-of-references] 93
  • [Other-IDs] NLM/ PMC3181821
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80. Lu KT, Wu CY, Cheng NC, Wo YY, Yang JT, Yen HH, Yang YL: Inhibition of the Na+ -K+ -2Cl- -cotransporter in choroid plexus attenuates traumatic brain injury-induced brain edema and neuronal damage. Eur J Pharmacol; 2006 Oct 24;548(1-3):99-105
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  • [Title] Inhibition of the Na+ -K+ -2Cl- -cotransporter in choroid plexus attenuates traumatic brain injury-induced brain edema and neuronal damage.
  • We found that the expression of NKCC1 RNA and protein were up-regulated in choroid plexus apical membrane from 2 h after traumatic brain injury, peaked at 8 h, and lasted for 24 h.
  • [MeSH-minor] Animals. Choroid Plexus / drug effects. Choroid Plexus / metabolism. Choroid Plexus / pathology. Diuretics / pharmacology. Male. Neurons / drug effects. Neurons / metabolism. Neurons / pathology. Neuroprotective Agents / pharmacology. RNA / biosynthesis. Rats. Rats, Wistar. Sodium-Potassium-Chloride Symporters / biosynthesis. Solute Carrier Family 12, Member 2

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  • (PMID = 16962576.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Diuretics; 0 / Neuroprotective Agents; 0 / Slc12a2 protein, rat; 0 / Sodium Potassium Chloride Symporter Inhibitors; 0 / Sodium-Potassium-Chloride Symporters; 0 / Solute Carrier Family 12, Member 2; 0Y2S3XUQ5H / Bumetanide; 63231-63-0 / RNA
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81. Isager P, Østerlind A, Engholm G, Heegaard S, Lindegaard J, Overgaard J, Storm HH: Uveal and conjunctival malignant melanoma in Denmark, 1943-97: incidence and validation study. Ophthalmic Epidemiol; 2005 Aug;12(4):223-32
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  • Age-period-cohort modelling of the incidence rates was done based on age at diagnosis, calendar period and birth cohort in 5-year groups and for each gender.
  • Calendar period and birth cohort had no effect on the incidence in the ocular region or in the topography subgroups choroid/ciliary body and conjunctiva.
  • The incidence of iris melanomas increased substantially, whereas the rate was stable for choroid/ciliary body and conjunctival melanomas.


82. Moura LR, Ayres B, Feijóo L, Romano S, Odashiro AN, Burnier MN Jr: Presumed eccrine carcinoma metastatic to the choroid. Clin Exp Ophthalmol; 2006 Sep-Oct;34(7):699-700
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  • [Title] Presumed eccrine carcinoma metastatic to the choroid.
  • This is a rare aggressive neoplasm with poor outcome in most cases of metastatic disease, and in this case report, uveal metastasis was indicative of poor prognosis.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16970766.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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83. Rucker FJ, Wallman J: Chick eyes compensate for chromatic simulations of hyperopic and myopic defocus: evidence that the eye uses longitudinal chromatic aberration to guide eye-growth. Vision Res; 2009 Jul;49(14):1775-83
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  • To minimize the effects of altered eye-growth on image contrast, we studied only the earliest responses: first, we measured changes in choroidal thickness 45 min to 1 h after one 15-min episode in the drum, then we measured glycosaminoglycans (GAG) synthesis in sclera and choroid (by the incorporation of labeled sulfate in tissue culture) after a day of four 30-min episodes in the drum.

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  • (PMID = 19383509.001).
  • [ISSN] 1878-5646
  • [Journal-full-title] Vision research
  • [ISO-abbreviation] Vision Res.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR-03060; United States / NEI NIH HHS / EY / R01 EY002727; United States / NCRR NIH HHS / RR / G12 RR003060; United States / NEI NIH HHS / EY / R37 EY002727; United States / NEI NIH HHS / EY / R01 EY002727-29; United States / NEI NIH HHS / EY / EY002727-29; United States / NEI NIH HHS / EY / EY-02727
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS111767; NLM/ PMC2779109
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84. Owler BK, Pitham T, Wang D: Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus. Cerebrospinal Fluid Res; 2010;7:15
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  • The discovery of a family of membrane water channel proteins called aquaporins, and the finding that aquaporin 1 was located in the choroid plexus, has prompted interest in the role of aquaporins in cerebrospinal fluid (CSF) production and consequently hydrocephalus.

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  • (PMID = 20860832.001).
  • [ISSN] 1743-8454
  • [Journal-full-title] Cerebrospinal fluid research
  • [ISO-abbreviation] Cerebrospinal Fluid Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2949735
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85. Chesney J, Telang S, Yalcin A, Clem A, Wallis N, Bucala R: Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality. Biochem Biophys Res Commun; 2005 May 27;331(1):139-46
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  • First, we cloned the mouse homolog of iPFK2 and found that it is abundantly expressed in cortical neurons, epithelial cells, and secretory cells of the choroid plexus, pancreas, and adrenal gland of the adult mouse.


86. Sun M, Forsman C, Sergi C, Gopalakrishnan R, O'Connor MB, Petryk A: The expression of twisted gastrulation in postnatal mouse brain and functional implications. Neuroscience; 2010 Aug 25;169(2):920-31
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  • We show that Twsg1 is expressed in the adult mouse brain in the choroid plexus (CP), hippocampus, and other regions, with the strongest expression observed in CP.

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  • [Copyright] Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
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  • (PMID = 20493240.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01DE016601; United States / NIDCR NIH HHS / DE / R01 DE016601; United States / NIDCR NIH HHS / DE / R01 DE016601-03; United States / Howard Hughes Medical Institute / / ; United States / NIDCR NIH HHS / DE / DE016601-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins; 0 / Ligands; 0 / Proteins; 0 / Transforming Growth Factor beta; 0 / twisted gastrulation protein, mouse; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors
  • [Other-IDs] NLM/ NIHMS223925; NLM/ PMC2971674
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87. Warf BC, Kulkarni AV: Intraoperative assessment of cerebral aqueduct patency and cisternal scarring: impact on success of endoscopic third ventriculostomy in 403 African children. J Neurosurg Pediatr; 2010 Feb;5(2):204-9
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  • Several independent variables were tested in a single multivariable model, including those previously shown to be associated with ETV survival, that is, age, hydrocephalus etiology, and extent of choroid plexus cauterization (CPC).

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  • (PMID = 20121373.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Glenn JV, Beattie JR, Barrett L, Frizzell N, Thorpe SR, Boulton ME, McGarvey JJ, Stitt AW: Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging. FASEB J; 2007 Nov;21(13):3542-52
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  • Bruch's membrane and the innermost layers of the underlying choroid (BM-Ch) were dissected from fresh postmortem eye-cups (n=56).

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  • (PMID = 17567569.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0600053; United States / NIDDK NIH HHS / DK / DK19971; United Kingdom / Wellcome Trust / / WT066193
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycosylation End Products, Advanced
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89. Cho NH, Kim YT, Lee JH, Song C, Cho SW, Cho SH, Chi JG: Diagnostic challenge of fetal ontogeny and its application on the ovarian teratomas. Int J Gynecol Pathol; 2005 Apr;24(2):173-82
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  • Although neuroepithelial tubules (NET) often are a component of immature teratoma (IT), they are not always required for diagnosis.
  • The teratomatous components used as a roadmap to evaluate maturity included: a lobular structure of primitive endodermal tubules (FA 4 to 6 weeks), a ventricle-lined cortical plate (FA 9 weeks), a complex papillary choroid plexus (FA 10 weeks), melanin deposition in hair follicles (FA 15 weeks), and the bell stage of odontogenesis (FA 19 weeks).

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  • (PMID = 15782074.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Senapati SN, Samanta DR, Das PK, Byondyopadhyay A, Mohantya A: Choroid and cutaneous metastasis from a testicular tumor. Hematol Oncol Stem Cell Ther; 2008 Oct-Dec;1(4):249-51
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  • [Title] Choroid and cutaneous metastasis from a testicular tumor.
  • [MeSH-major] Choroid Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / pathology. Skin Neoplasms / secondary. Testicular Neoplasms / pathology

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  • (PMID = 20058483.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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91. Pérez-Blázquez E: [Ophthalmoscopic surveillance in treated patients with invasive Candida disease]. Rev Iberoam Micol; 2009 Mar 31;26(1):78-80
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  • [Transliterated title] Importancia de la vigilancia oftalmológica durante el tratamiento de la enfermedad invasora por Candida.
  • There are two characteristic ocular signs: Candida chorioretinitis defined as retina and choroid lesions without vitreal involvement, and Candida endophthalmitis defined as chorioretinitis with extension into the vitreous with characteristic fluffy balls.
  • [MeSH-major] Candidiasis / complications. Chorioretinitis / diagnosis. Endophthalmitis / diagnosis. Fungemia / complications. Ophthalmoscopy
  • [MeSH-minor] Adult. Child. Critical Illness. Humans. Immunocompromised Host. Infant, Newborn. Infant, Premature. Infant, Premature, Diseases / diagnosis. Infant, Premature, Diseases / epidemiology. Infant, Premature, Diseases / microbiology. Infant, Premature, Diseases / prevention & control. Neoplasms / complications. Neutropenia / complications. Prevalence

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  • (PMID = 19463283.001).
  • [ISSN] 1130-1406
  • [Journal-full-title] Revista iberoamericana de micología
  • [ISO-abbreviation] Rev Iberoam Micol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 28
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92. Pérez Blázquez E: [Ophtalmoscopic examination in critically ill non-neutropenic patients: Candida endophtalmitis]. Rev Iberoam Micol; 2006 Mar;23(1):16-9
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  • [Transliterated title] Fondo de ojo en el paciente crítico no neutropénico: endoftalmitis candidiásica.
  • There are two characteristic ocular signs: Candida chorioretinitis defined as retina and choroid lesions without vitreal involvement, and Candida endophthalmitis defined as chorioretinitis with extension into the vitreous with characteristic fluffy balls.
  • [MeSH-major] Candidiasis / diagnosis. Endophthalmitis / diagnosis. Endophthalmitis / microbiology. Eye Infections, Fungal / diagnosis. Ophthalmoscopy

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  • (PMID = 16499424.001).
  • [ISSN] 1130-1406
  • [Journal-full-title] Revista iberoamericana de micología
  • [ISO-abbreviation] Rev Iberoam Micol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 24
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93. Wang LC, Wan DP, Jung SM, Chen CC, Wong HF, Wan YL: Magnetic resonance imaging findings in the brains of rabbits infected with Angiostrongylus cantonensis: a long-term investigation. J Parasitol; 2005 Oct;91(5):1237-9
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  • Histological examination from days 108 to 207 PI revealed meningeal congestion, choroid plexus inflammation, infarction, granuloma with embedded larva, gliosis, and hemorrhage in the brain tissues.


94. Melo DH, Pierre Filho Pde T, Gomes PR, Holanda AG, Amadei LP: [Choroidal metastasis of gastric adenocarcinoma as a first sign of systemic disease recurrence: case report]. Arq Bras Oftalmol; 2010 Sep-Oct;73(5):467-8
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  • [Transliterated title] Metástase de adenocarcinoma gástrico para a coróide como um primeiro sinal de recorrência de doença sistêmica: relato de caso.
  • Examination of the left eye revealed an elevated creamy yellow choroidal tumor infiltrating the macular area and extending around the optic nerve head, suggesting metastasis.
  • There was orbital recurrence of the tumor, leading to exenteration.
  • This patient represents a rare occurrence of metastatic gastric adenocarcinoma to the choroid, developing as a first sign of systemic recurrence.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Orbital Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 21225136.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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95. Banka S, Walsh R, Brundler MA: First report of occurrence of choroid plexus papilloma and medulloblastoma in the same patient. Childs Nerv Syst; 2007 May;23(5):587-9
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  • [Title] First report of occurrence of choroid plexus papilloma and medulloblastoma in the same patient.
  • INTRODUCTION: Choroid plexus papilloma is a benign epithelial brain tumour showing a striking predilection for infants and occurring most frequently in the lateral and fourth ventricles.
  • Medulloblastoma, on the other hand, is a primitive neuroectodermal tumour and is the most frequent malignant brain tumour of the posterior fossa in children.
  • In this study, we report a metachronous occurrence of choroid plexus papilloma and medulloblastoma in the same patient, which has not been reported before to the best of our knowledge.
  • CASE REPORT: The authors describe the case of a girl who presented with an atypical choroid plexus papilloma on the posterior wall of the left lateral ventricle at 3 months of age that was resected completely.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Medulloblastoma / pathology. Papilloma, Choroid Plexus / pathology

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  • [ISSN] 0256-7040
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96. Stefanović I, Dacić-Krnjaja B, Djurić S: [Ultrasound biomicroscopy in diagnosis of anterior segment pathology]. Srp Arh Celok Lek; 2009 Mar-Apr;137(3-4):185-8
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  • [Title] [Ultrasound biomicroscopy in diagnosis of anterior segment pathology].
  • The existence of the ciliary body tumour was suspected, so she underwent a UBM diagnostic procedure.
  • UBM showed fibrin in the anterior chamber of the eye, occlusion of the pupil, and the absence of tumour.
  • UBM showed a solid tumour lesion filling the chamber angle in the lower part of the anterior chamber.
  • The origin of the tumour was the ciliary body rather than the choroid which was shown by the B scan ultrasound.

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  • (PMID = 19459567.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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97. Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, Viaño J: Sturge-Weber syndrome: study of 55 patients. Can J Neurol Sci; 2008 Jul;35(3):301-7
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  • All patients with unilateral or bilateral upper eyelid nevus flammeus had ipsilateral, unilateral or bilateral choroid-retinal angiomas.


98. Abbott NJ: Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol Neurobiol; 2005 Feb;25(1):5-23
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  • (1) Three main barrier layers at the interface between blood and tissue protect the central nervous system (CNS): the endothelium of brain capillaries, and the epithelia of the choroid plexus (CP) and the arachnoid.

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  • (PMID = 15962506.001).
  • [ISSN] 0272-4340
  • [Journal-full-title] Cellular and molecular neurobiology
  • [ISO-abbreviation] Cell. Mol. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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99. Vargas T, Antequera D, Ugalde C, Spuch C, Carro E: Gelsolin restores A beta-induced alterations in choroid plexus epithelium. J Biomed Biotechnol; 2010;2010:805405
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  • [Title] Gelsolin restores A beta-induced alterations in choroid plexus epithelium.
  • In previous studies we demonstrated that in AD patients, amyloid-beta (A beta) peptide also accumulates in choroid plexus, and that this process is associated with mitochondrial dysfunction and epithelial cell death.
  • However, the molecular mechanisms underlying A beta accumulation at the choroid plexus epithelium remain unclear.
  • A beta clearance, from the brain to the blood, involves A beta carrier proteins that bind to megalin, including gelsolin, a protein produced specifically by the choroid plexus epithelial cells.
  • In this study, we show that treatment with gelsolin reduces A beta-induced cytoskeletal disruption of blood-cerebrospinal fluid (CSF) barrier at the choroid plexus.
  • [MeSH-major] Amyloid beta-Peptides / metabolism. Choroid Plexus / drug effects. Choroid Plexus / metabolism. Gelsolin / pharmacology

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  • (PMID = 20369065.001).
  • [ISSN] 1110-7251
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid beta-Peptides; 0 / Cell Extracts; 0 / Gelsolin; 0 / Low Density Lipoprotein Receptor-Related Protein-2; 31C4KY9ESH / Nitric Oxide
  • [Other-IDs] NLM/ PMC2847388
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100. Wang RK, An L, Francis P, Wilson DJ: Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. Opt Lett; 2010 May 1;35(9):1467-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography.
  • We demonstrate the depth-resolved and detailed ocular perfusion maps within retina and choroid can be obtained from an ultrahigh sensitive optical microangiography (OMAG).
  • We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology.

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  • [Cites] Opt Express. 2009 Mar 2;17(5):4166-76 [19259253.001]
  • [Cites] Opt Express. 2008 Jul 21;16(15):11438-52 [18648464.001]
  • (PMID = 20436605.001).
  • [ISSN] 1539-4794
  • [Journal-full-title] Optics letters
  • [ISO-abbreviation] Opt Lett
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC010201; United States / NIBIB NIH HHS / EB / R01 EB009682-01; United States / NHLBI NIH HHS / HL / R01 HL093140-01; United States / NHLBI NIH HHS / HL / R01 HL093140; United States / NIBIB NIH HHS / EB / R01EB009682; United States / NHLBI NIH HHS / HL / HL093140-01S1; United States / NIDCD NIH HHS / DC / R01DC010201; United States / NHLBI NIH HHS / HL / HL093140-02; United States / NIDCD NIH HHS / DC / R01 DC010201-01; United States / NHLBI NIH HHS / HL / R01 HL093140-02; United States / NHLBI NIH HHS / HL / HL093140-01; United States / NHLBI NIH HHS / HL / R01HL093140; United States / NIDCD NIH HHS / DC / DC010201-01; United States / NHLBI NIH HHS / HL / R01 HL093140-01S1; United States / NIBIB NIH HHS / EB / EB009682-01; United States / NIBIB NIH HHS / EB / R01 EB009682
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS193314; NLM/ PMC2864924
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