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1. Muller HL: Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm Res; 2008;69(4):193-202
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  • [Title] Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up.
  • BACKGROUND: Craniopharyngioma are embryogenic malformations of the sellar area.
  • With an overall incidence of 0.5-2 new cases per million population per year, 30-50% of all cases occur in childhood.
  • METHODS: Based on retrospective analysis of 306 patients with childhood craniopharyngioma (HIT ENDO), we found that QoL was negatively related to hypothalamic involvement, tumor size and the number of neurosurgical interventions.
  • The prospective surveillance of 98 patients in KRANIOPHARYNGEOM 2000 revealed frequent and early events in terms of tumor relapse after apparently complete resection (EFS: 0.60 +/- 0.09 at 3 years) and tumor progression after incomplete resection (EFS: 0.22 +/- 0.09).
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18204266.001).
  • [ISSN] 1423-0046
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 53
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2. Müller HL: Increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives. Int J Endocrinol; 2010;2010:519607

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  • [Title] Increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives.
  • Childhood craniopharyngiomas are rare embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium.
  • Significant daytime sleepiness and disturbances of circadian rhythms have been demonstrated in obese childhood craniopharyngioma patients.
  • Reports on a beneficial effect of treatment with central stimulating agents supported the hypothesis that secondary narcolepsy should be considered as a rare cause for severe daytime sleepiness in patients with childhood craniopharyngioma.

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  • (PMID = 21234339.001).
  • [ISSN] 1687-8345
  • [Journal-full-title] International journal of endocrinology
  • [ISO-abbreviation] Int J Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3017941
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3. Crom DB, Smith D, Xiong Z, Onar A, Hudson MM, Merchant TE, Morris EB: Health status in long-term survivors of pediatric craniopharyngiomas. J Neurosci Nurs; 2010 Dec;42(6):323-8; quiz 329-30
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  • [Title] Health status in long-term survivors of pediatric craniopharyngiomas.
  • Craniopharyngiomas are the third most common pediatric brain tumor and most common pediatric suprasellar tumor.
  • The purpose of this study was to analyze the health status of long-term survivors of pediatric craniopharyngioma treated primarily with radiation and conservative surgical resection.
  • Medical records of all long-term survivors of craniopharyngioma treated at St. Jude Children's Research Hospital and then transferred to the long-term follow-up clinic were reviewed.
  • In a small percentage of patients, complications may result in death even during extended remission of craniopharyngioma.
  • Because of the broad spectrum or morbidities experienced, survivors of craniopharyngioma continue to benefit from multidisciplinary care.

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  • (PMID = 21207770.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS756555; NLM/ PMC4895693
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4. Schultes B, Ernst B, Schmid F, Thurnheer M: Distal gastric bypass surgery for the treatment of hypothalamic obesity after childhood craniopharyngioma. Eur J Endocrinol; 2009 Jul;161(1):201-6
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  • [Title] Distal gastric bypass surgery for the treatment of hypothalamic obesity after childhood craniopharyngioma.
  • OBJECTIVE: Our goal was to describe the course of hypothalamic obesity in a craniopharyngioma patient treated with distal gastric bypass surgery and to outline distinct aspects of multidisciplinary case management.
  • PATIENT AND METHODS: A 29-year-old man, who had undergone craniopharyngioma resection at the age of 8, was referred to our Interdisciplinary Obesity Centre with a body mass index (BMI) of 52.0 kg/m(2), type 2 diabetes and obstructive sleep apnoea syndrome (OSAS).


5. Trivin C, Busiah K, Mahlaoui N, Recasens C, Souberbielle JC, Zerah M, Sainte-Rose C, Brauner R: Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index. BMC Pediatr; 2009;9:24
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  • [Title] Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index.
  • BACKGROUND: Obesity seems to be linked to the hypothalamic involvement in craniopharyngioma.
  • METHODS: 27 children with craniopharyngioma were classified as either grade 0 (n = 7, no hypothalamic involvement), grade 1 (n = 8, compression without involvement), or grade 2 (n = 12, severe involvement).
  • CONCLUSION: The hypothalamic involvement by the craniopharyngioma before surgery seems to determine the degree of insulin resistance, regardless of the BMI.
  • [MeSH-major] Craniopharyngioma / pathology. Hypothalamus / pathology. Insulin Resistance. Obesity / etiology. Pituitary Neoplasms / pathology

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  • (PMID = 19341477.001).
  • [ISSN] 1471-2431
  • [Journal-full-title] BMC pediatrics
  • [ISO-abbreviation] BMC Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Ghrelin; 0 / Leptin; 0 / Receptors, Leptin; 67763-96-6 / Insulin-Like Growth Factor I; Q51BO43MG4 / Thyroxine; WI4X0X7BPJ / Hydrocortisone
  • [Other-IDs] NLM/ PMC2675525
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6. Kim RJ, Shah R, Tershakovec AM, Zemel BS, Sutton LN, Grimberg A, Moshang T: Energy expenditure in obesity associated with craniopharyngioma. Childs Nerv Syst; 2010 Jul;26(7):913-7
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  • [Title] Energy expenditure in obesity associated with craniopharyngioma.
  • BACKGROUND AND PURPOSE: Obesity is a common yet incompletely understood complication of childhood craniopharyngioma.
  • We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children.
  • METHODS: Eleven craniopharyngioma patients were recruited for a study on body composition and energy balance.
  • The obese craniopharyngioma patients had a mean age (+/-SD) of 11.2 +/- 1.7 years.
  • RESULTS: Obese craniopharyngioma patient subjects had increased mean (+/-standard error) fat-free mass compared to obese controls (57% +/- 0.88 % vs 50.0% +/- 0.87%, p = 0.02).
  • The obese craniopharyngioma patients had a 17% lower REE compared to values expected from the World Health Organization equation (1,541 +/- 112.6 vs 1,809 +/- 151.8 kcal; p = 0.01).
  • CONCLUSIONS: Lower REE may be a factor contributing to obesity in children with craniopharyngioma.
  • Further study is needed into the mechanisms for reduced energy expenditure in patients with craniopharyngioma.

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  • (PMID = 20107994.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK080644-01A1; United States / NIDDK NIH HHS / DK / K12 DK063682; United States / NCRR NIH HHS / RR / UL1RR024134; United States / NIDDK NIH HHS / DK / K23 DK080644-01A1; United States / NCRR NIH HHS / RR / UL1 RR024134
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Other-IDs] NLM/ NIHMS189864; NLM/ PMC2883002
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7. Kiehna EN, Merchant TE: Radiation therapy for pediatric craniopharyngioma. Neurosurg Focus; 2010 Apr;28(4):E10
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  • [Title] Radiation therapy for pediatric craniopharyngioma.
  • OBJECT: The treatment of craniopharyngioma is highly controversial.
  • METHODS: An extensive literature review was performed for all studies including radiation therapy, with or without surgery, for pediatric craniopharyngioma.
  • RESULTS: The authors identified 32 papers describing radiation therapy for treatment of pediatric craniopharyngioma, with disease control ranging from 44 to 100%.
  • CONCLUSIONS: Conservative surgery and radiation therapy results in long-term disease control in pediatric patients with craniopharyngioma that is comparable to results obtained with radical surgery alone.
  • However, children with craniopharyngioma remain vulnerable to late treatment failures and side effects from radiation therapy, including endocrinopathies, vasculopathies, and secondary tumors, which may be detrimental to the quality of life.
  • Long-term follow-up beyond 5-10 years is necessary to assess tumor control relative to functional outcomes.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radiotherapy, Conformal / methods

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  • (PMID = 20367354.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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8. Beltran C, Naik M, Merchant TE: Dosimetric effect of target expansion and setup uncertainty during radiation therapy in pediatric craniopharyngioma. Radiother Oncol; 2010 Dec;97(3):399-403
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  • [Title] Dosimetric effect of target expansion and setup uncertainty during radiation therapy in pediatric craniopharyngioma.
  • PURPOSE: Investigate the effect of tumor change and setup uncertainties on target coverage for pediatric craniopharyngioma during RT.
  • METHODS AND MATERIALS: Fifteen pediatric patients with craniopharyngioma (mean 5.1 years) were included in this study.
  • MRI was performed before and a median of six times during RT to monitor changes in the tumor volume.
  • CONCLUSIONS: The GTV of pediatric craniopharyngioma patients change size during therapy and adaptive planning is critical for conformal plans; therefore early and regular surveillance imaging is required.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy, Conformal. Radiotherapy, Intensity-Modulated

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  • [Copyright] Copyright © 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 21074883.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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9. Luu QT, Loredo LN, Archambeau JO, Yonemoto LT, Slater JM, Slater JD: Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report. Cancer J; 2006 Mar-Apr;12(2):155-9
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  • [Title] Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report.
  • This retrospective preliminary review evaluated the efficacy and toxicity of fractionated proton radiotherapy in the management of pediatric craniopharyngioma.
  • All had undergone at least one tumor resection.
  • DISCUSSION: Fractionated proton radiotherapy is an effective treatment for children with craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy. Protons / therapeutic use. Radiotherapy, Conformal / methods

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  • (PMID = 16630407.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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10. Waber DP, Pomeroy SL, Chiverton AM, Kieran MW, Scott RM, Goumnerova LC, Rivkin MJ: Everyday cognitive function after craniopharyngioma in childhood. Pediatr Neurol; 2006 Jan;34(1):13-9
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  • [Title] Everyday cognitive function after craniopharyngioma in childhood.
  • Despite clinical impressions that cognitive complaints are prominent in patients with a history of craniopharyngioma, formal neuropsychologic documentation is inconsistent.
  • This study assessed everyday cognitive complaints and neuropsychologic test performance to evaluate the prevalence of problems and the relationship of these domains to one another in patients treated for craniopharyngioma in childhood or adolescence.
  • Ten patients treated for craniopharyngioma completed measures of everyday cognitive function (Cognitive Failures Questionnaire, Rivermead Behavioural Memory Test) and a battery of standard neuropsychologic tests.
  • Adolescents and young adults with treated craniopharyngioma experience deficits in everyday cognitive functions, many involving memory, that are not easily detected by standard neuropsychologic testing.
  • [MeSH-major] Activities of Daily Living / psychology. Cognition Disorders / etiology. Craniopharyngioma / psychology. Memory Disorders / etiology. Pituitary Neoplasms / psychology

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  • (PMID = 16376272.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P30-HD18655
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Hamid R, Sarkar S, Hossain MA, Mazumder U, Akanda NI, Parvin R: Clinical picture of craniopharyngioma in childhood. Mymensingh Med J; 2007 Jul;16(2):123-6
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  • [Title] Clinical picture of craniopharyngioma in childhood.
  • Although there is a bi-modal age distribution-1st peak at 5-10 years and the 2nd peak at 55-65 years, the common patients are children (9% of childhood tumour).
  • A typical child with Craniopharyngioma (CP) is short, obese and half blind and has a poor school record.
  • We found major endocrinological deficiency in child patients with Craniopharyngioma in 17% cases.


12. Thompson D, Phipps K, Hayward R: Craniopharyngioma in childhood: our evidence-based approach to management. Childs Nerv Syst; 2005 Aug;21(8-9):660-8
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  • [Title] Craniopharyngioma in childhood: our evidence-based approach to management.
  • OBJECTIVES: In 1996 we published our results for treatment of childhood craniopharyngioma.
  • As result of that study, we redefined the role of radical surgery in the treatment of craniopharyngioma and developed a new treatment strategy in an attempt to improve the quality of outcome without compromising tumour control.
  • METHODS: A detailed assessment of the treatment pathway and outcome was undertaken for children treated for craniopharyngioma in our unit from 1996 to 2004.
  • RESULTS: Forty-eight children with craniopharyngioma presented in the study period.
  • CONCLUSIONS: A treatment paradigm for childhood craniopharyngioma is presented which improves the quality of outcome without compromising tumour control.
  • [MeSH-major] Craniopharyngioma / therapy. Evidence-Based Medicine. Pituitary Neoplasms / therapy

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  • [Cites] J Clin Endocrinol Metab. 1996 Jul;81(7):2734-7 [8675604.001]
  • [Cites] J Neurosurg. 1990 Jul;73(1):3-11 [2352020.001]
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  • [Cites] Childs Nerv Syst. 2001 Dec;17 (12 ):724-30 [11862438.001]
  • [Cites] J Neurosurg. 1992 Jan;76(1):47-52 [1727168.001]
  • (PMID = 15959733.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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13. Kadri H, Mawla AA: Endoscopy-assisted microsurgical total resection of craniopharyngioma in childhood. Minim Invasive Neurosurg; 2006 Dec;49(6):369-72
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  • [Title] Endoscopy-assisted microsurgical total resection of craniopharyngioma in childhood.
  • Craniopharyngioma is a benign tumour that needs total resection to reduce the recurrence rate and consequently improve the quality of life for the affected children.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopes. Microsurgery / instrumentation. Pituitary Neoplasms / surgery

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  • (PMID = 17323266.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Pancucci G, Massimi L, Caldarelli M, D'Angelo L, Sturiale C, Tamburrini G, Tufo T, Di Rocco C: [Pediatric craniopharyngioma: long-term results in 61 cases]. Minerva Pediatr; 2007 Jun;59(3):219-31
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  • [Title] [Pediatric craniopharyngioma: long-term results in 61 cases].
  • AIM: The aim of this study was to analyze the long-term results of the surgical management of craniopharyngioma in children by reviewing a series of patients consecutively treated in a single institution, and to assess the efficacy of intratumoral chemotherapy with interferon-alpha.
  • CONCLUSION: The current experience confirms the still remarkable challenges in the treatment of craniopharyngioma in childhood.
  • [MeSH-major] Brain / pathology. Craniopharyngioma / therapy. Hypophysectomy. Pituitary Neoplasms / therapy

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  • (PMID = 17519867.001).
  • [ISSN] 0026-4946
  • [Journal-full-title] Minerva pediatrica
  • [ISO-abbreviation] Minerva Pediatr.
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 76543-88-9 / interferon alfa-2a
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15. Müller HL, Gebhardt U, Wessel V, Schröder S, Kolb R, Sörensen N, Maroske J, Hanisch E: First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity. Klin Padiatr; 2007 Nov-Dec;219(6):323-5
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  • [Title] First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity.
  • Craniopharyngiomas are embryogenic malformations which lead to eating disorders and morbid obesity due to hypothalamic involvement in about 50% of all patients with pediatric craniopharyngioma.
  • The experience with laparoscopic adjustable gastric banding (LAGB) in obese craniopharyngioma patients is limited.
  • We are reporting on four patients with childhood craniopharyngioma diagnosed at age 2, 11, 12, and 21 years.
  • We conclude that LAGB could be effective in weight reduction of obese craniopharyngioma patients with hypothalamic syndrome.
  • Close follow-up is necessary in order to analyze long-term effects and complications of LAGB in patients with childhood craniopharyngioma and morbid obesity.
  • [MeSH-major] Craniopharyngioma / complications. Gastroplasty. Laparoscopy. Obesity, Morbid / etiology. Obesity, Morbid / surgery. Pituitary Neoplasms / complications

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  • (PMID = 18050042.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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16. Liu AK, Bagrosky B, Fenton LZ, Gaspar LE, Handler MH, McNatt SA, Foreman NK: Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy. Pediatr Blood Cancer; 2009 Feb;52(2):227-30
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  • [Title] Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy.
  • BACKGROUND: Craniopharyngioma is a benign brain tumor that can be treated with some combination of surgery, intracystic chemotherapy and radiation therapy.
  • Treatment for craniopharyngioma, especially radiation therapy, is associated with a variety of long-term toxicities including vascular abnormalities.
  • We report on the incidence of vascular abnormalities seen in the children with craniopharyngioma who received radiation therapy at our institution.
  • PROCEDURE: We reviewed our experience with craniopharyngioma patients who received radiation therapy from 1995 to 2008.
  • RESULTS: Twenty of the 22 children with craniopharyngioma who received radiation therapy had imaging available.
  • CONCLUSIONS: We report a high incidence of vascular abnormalities in children with craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / complications. Craniopharyngioma / radiotherapy. Vascular Diseases / etiology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18937328.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin
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17. Pedreira CC, Stargatt R, Maroulis H, Rosenfeld J, Maixner W, Warne GL, Zacharin MR: Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood. J Pediatr Endocrinol Metab; 2006 Jan;19(1):15-24
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  • [Title] Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood.
  • Patients with craniopharyngioma are at risk for many adverse effects related to the tumour's invasive behaviour and its proximity to many vital structures.
  • Profound psychosocial problems, memory impairment, pituitary and hypothalamic dysfunction in addition to the physical handicap of visual loss are frequently recognized sequelae of craniopharyngioma treatment.
  • OBJECTIVES: To examine health related quality of life (QoL) and psychological outcomes of patients treated for craniopharyngioma at the Royal Children's Hospital, Melbourne, between January 1980 and September 2003.
  • Few craniopharyngioma survivors (18/30) were available for evaluation, demonstrating difficulties in attempts to assess this complex group.
  • CONCLUSIONS: Craniopharyngioma and its treatment result in significant, complex medical, social, psychological and emotional difficulties.
  • [MeSH-major] Craniopharyngioma / psychology. Hypothalamus / physiopathology. Pituitary Neoplasms / psychology. Quality of Life / psychology

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  • [CommentIn] J Pediatr Endocrinol Metab. 2006 Jan;19(1):11-3 [16509523.001]
  • (PMID = 16509524.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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18. May JA, Krieger MD, Bowen I, Geffner ME: Craniopharyngioma in childhood. Adv Pediatr; 2006;53:183-209
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  • [Title] Craniopharyngioma in childhood.
  • In summary, much progress has been made in our understanding of childhood craniopharyngiomas.
  • These histologically benign but "geographically malignant" tumors are challenging to treat and require experienced clinicians from multiple disciplines including neurosurgery, radiology, hematology/oncology, ophthalmology, endocrinology, and general pediatrics to address the multiple issues that arise with diagnosis, treatment, and long-term follow-up of affected children.
  • [MeSH-major] Craniopharyngioma. Pituitary Neoplasms
  • [MeSH-minor] Child. Combined Modality Therapy. Growth Hormone / therapeutic use. Humans. Hypothalamo-Hypophyseal System / physiopathology. Obesity / physiopathology. Radiotherapy Dosage. Wnt Proteins / genetics

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  • (PMID = 17089867.001).
  • [ISSN] 0065-3101
  • [Journal-full-title] Advances in pediatrics
  • [ISO-abbreviation] Adv Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 9002-72-6 / Growth Hormone
  • [Number-of-references] 102
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19. Müller HL, Gebhardt U, Etavard-Gorris N, Kolb R, Warmuth-Metz M, Sörensen N: Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up--recommendations in KRANIOPHARYNGEOM 2000. Onkologie; 2005 Mar;28(3):150-6
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  • [Title] Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up--recommendations in KRANIOPHARYNGEOM 2000.
  • As the survival rate after craniopharyngioma diagnosed during childhood and adolescence is high, prognosis and quality of life (QoL) in survivors mainly depend on adverse late effects such as hypopituitarism and obesity.
  • In order to evaluate and standardize diagnostic and therapeutical strategies in childhood craniopharyngioma the prospective multicenter surveillance study KRANIOPHARYNGEOM 2000 was initiated for patients diagnosed with craniopharyngioma during childhood and adolescence.
  • We are reporting on current strategies for laboratory diagnostics and endocrine substitution in patients with childhood craniopharyngioma recruited in KRANIOPHARYNGEOM 2000.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Diabetes Insipidus, Neurogenic / diagnosis. Diabetes Insipidus, Neurogenic / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • (PMID = 15772466.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 24
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20. Elliott RE, Moshel YA, Wisoff JH: Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases. J Neurosurg Pediatr; 2009 Aug;4(2):105-12
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  • [Title] Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases.
  • Local recurrence following radical resection is one of the most common complications of pediatric craniopharyngioma.
  • Only 28 cases of ectopic recurrence of craniopharyngioma have been reported in the literature, and only 13 cases occurred in patients originally treated as children.
  • In this consecutive series of 86 children who underwent radical resection of primary and recurrent craniopharyngiomas, 4 patients (4.7%) experienced ectopic tumor recurrence, accounting for 27% of all recurrences after gross-total resection.
  • The authors report on the successful surgical treatment of these 4 patients and the impact of ectopic craniopharyngioma recurrence on survival.
  • [MeSH-major] Craniopharyngioma / secondary. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery

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  • (PMID = 19645541.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Hukin J, Visser J, Sargent M, Goddard K, Fryer C, Steinbok P: Childhood craniopharyngioma: Vancouver experience. Childs Nerv Syst; 2005 Aug;21(8-9):758-65
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  • [Title] Childhood craniopharyngioma: Vancouver experience.
  • OBJECTIVE: To present our institution's experience in the management of childhood craniopharyngioma since 1982.
  • METHODS: We retrospectively reviewed the records of all children diagnosed with craniopharyngioma at our children's hospital from its opening in 1982 through to 2003.
  • CONCLUSIONS: Most children diagnosed with craniopharyngioma are long-term survivors.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Irradiation. Pituitary Neoplasms / therapy

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  • [Cites] J Neurosurg. 1986 Jul;65(1):22-7 [3712025.001]
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  • (PMID = 15959732.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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22. Hafez MA, ElMekkawy S, AbdelBadie H, Mohy M, Omar M: Pediatric craniopharyngioma--rationale for multimodal management: the Egyptian experience. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:371-80
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  • [Title] Pediatric craniopharyngioma--rationale for multimodal management: the Egyptian experience.
  • BACKGROUND: Situated in a suprasellar location, craniopharyngiomas produce devastating endocrinological manifestations, visual impairment, and raised intracranial pressure, presenting a formidable disease entity for the neurosurgeon as well as the 'craniopharyngioma team'.
  • PATIENTS AND METHODS: Sixty-two new cases of pediatric craniopharyngioma were divided into three groups according to extent of removal: A (complete), B (subtotal), and C (partial).
  • Adjuvant radiotherapy is a useful tool in providing long-term tumor control.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Egypt. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Neurosurgical Procedures. Quality of Life. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16700313.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Müller HL, Handwerker G, Gebhardt U, Faldum A, Emser A, Kolb R, Sörensen N: Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control; 2006 May;17(4):583-9
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  • [Title] Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness.
  • Craniopharyngioma is a rare dysontogenetic benign tumor.
  • A self-assessment daytime sleepiness questionnaire (German version of the Epworth Sleepiness Scale [ESS]) was used to evaluate 79 patients with childhood craniopharyngioma.
  • Because hypothalamic lesions may explain daytime sleepiness in craniopharyngioma patients, salivary melatonin and cortisol concentrations were examined in severely obese (BMI>or=4SD) and non severely obese (BMI<4SD) craniopharyngioma patients (n=79), patients with hypothalamic pilocytic astrocytoma (n=19), and control subjects (n=30).
  • Using a general linear model procedure analyzing the influence of BMI and tumor diagnosis on diurnal salivary melatonin we found that morning salivary melatonin levels were related to BMI (F test: p-value=0.004) and tumor diagnosis (F-test: p-value=0.032).
  • Also for nighttime salivary melatonin levels significant relations with BMI (p-value in F-test: <0.001) and tumor diagnosis (p-value in F-test: 0.025) were detectable.
  • Melatonin concentrations in saliva of craniopharyngioma patients collected at nighttime or in the morning showed a negative correlation (Spearman's rho: -0.42; p=0.001; Spearman's rho: -0.31; p=0.020) with the patient's ESS score.
  • Severely obese craniopharyngioma patients and severely obese hypothalamic tumor patients had similar patterns of melatonin secretion.
  • As decreased nocturnal melatonin levels were associated with increased daytime sleepiness, BMI and hypothalamic tumor diagnosis, we initiated an experimental melatonin substitution in 10 adult obese patients (5f/5m) with childhood craniopharyngioma.
  • In all 10 patients with childhood craniopharyngioma the degree of daytime sleepiness significantly improved based on activity diaries, ESS, self assessment questionnaires and actimetry.
  • [MeSH-major] Craniopharyngioma / metabolism. Melatonin / secretion. Melatonin / therapeutic use. Obesity / metabolism. Pituitary Neoplasms / metabolism. Sleep Stages


24. Liu ZX, Liu YS, Yuan XR, Liu JF: [Surgical treatment of childhood craniopharyngioma: clinical analysis of 31 cases]. Zhongguo Dang Dai Er Ke Za Zhi; 2009 Aug;11(8):663-5
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  • [Title] [Surgical treatment of childhood craniopharyngioma: clinical analysis of 31 cases].
  • OBJECTIVE: To study the diagnosis, surgical treatment and outcome of craniopharyngioma in 31 children.
  • METHODS: The clinical data of 31 children (aged 7-14 years) with craniopharyngioma were studied retrospectively.
  • The 31 children were definitely diagnosed with craniopharyngioma by CT and MRI.
  • In the 31 cases, 19 (61.3%) underwent total tumor removal, 5 (16.1%) subtotal removal, and 7 (22.6%) partial removal.
  • After tumor removal, transient diabetes insipidus occurred in 19 cases (61.3%) and long-term diabetes insipidus in 3 cases.
  • Five patients (16.1%) had recurrent tumor in a mean follow-up of 32.5 months.
  • CONCLUSIONS: The diagnosis of childhood craniopharyngioma may be based on clinical manifestations and CT/MRI examinations.
  • Proper extent of tumor resection should be determined in order to reduce the tumor recurrence and the incidence of postoperative complications.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery

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  • (PMID = 19695196.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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25. Erşahin Y, Yurtseven T, Ozgiray E, Mutluer S: Craniopharyngiomas in children: Turkey experience. Childs Nerv Syst; 2005 Aug;21(8-9):766-72
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  • Although they have a benign histology, total resection without morbidity is very difficult.
  • METHODS: We aimed to review the results of pediatric craniopharyngioma patients treated in eight institutions in Turkey.
  • The recurrence (28%) was significantly higher in patients with subtotal and partial tumor removal (P=0.010).
  • Bad outcome was significantly associated with tumor dimension (P=0.039); the greater the tumor dimension, the worse the outcome.
  • Gender, tumor type and location, presence of hydrocephalus and calcification, histological type of craniopharyngioma, and surgical approach did not have a significant effect on the outcome.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy

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  • (PMID = 16001286.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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26. Sands SA, Milner JS, Goldberg J, Mukhi V, Moliterno JA, Maxfield C, Wisoff JH: Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma. J Neurosurg; 2005 Oct;103(4 Suppl):302-11
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  • [Title] Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma.
  • Further analyses indicated that retrochiasmatic tumor location, recurrence, and additional surgery were associated with poorer outcomes.
  • In contrast, hydrocephalus, tumor size, and sex were not prognostic variables, and patients significantly improved as post-operative time increased.
  • CONCLUSIONS: Attention toward late effects arising after the treatment of pediatric craniopharyngioma, including decreased postoperative physical health and behavioral functioning, is warranted.
  • Future approaches to treatment should consider the documented effects of either gross-total resection or limited surgery followed by cranial irradiation on QOL, with specific evaluation for those with retrochiasmatic tumors, a recurrent tumor, or the need for additional surgery.
  • [MeSH-major] Child Behavior. Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Quality of Life. Social Behavior

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  • [CommentIn] J Neurosurg. 2005 Oct;103(4 Suppl):297-8; discussion 298 [16270679.001]
  • (PMID = 16270681.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Ohmori K, Collins J, Fukushima T: Craniopharyngiomas in children. Pediatr Neurosurg; 2007;43(4):265-78
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  • BACKGROUND: The modern era of pediatric craniopharyngioma treatment includes multiple modalities including microsurgical resection, irradiation, brachytherapy or chemotherapy.
  • The aim of this study was to describe the techniques and strategies for the treatment of pediatric craniopharyngiomas in light of a literature review with particular attention to the incidence of adverse postoperative effects.
  • METHODS: Twenty-seven pediatric patients (median age 9.0 years) who were surgically treated for craniopharyngiomas were evaluated.
  • CONCLUSIONS: For patients in whom early postoperative MRI reveals complete craniopharyngioma removal, a very low rate of recurrence is anticipated.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17627142.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 61
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28. Müller HL, Müller-Stöver S, Gebhardt U, Kolb R, Sörensen N, Handwerker G: Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:423-9
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  • [Title] Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients.
  • Prognosis in childhood craniopharyngioma survivors hinges upon late effects such as pituitary deficiency and obesity.
  • We analyzed the degree of daytime sleepiness in 115 childhood craniopharyngioma patients (47% obese) using the Epworth Sleepiness Scale (ESS).
  • Polysomnography (PSG) and Multiple Sleep Latency Tests (MSLT) were conducted with 10 obese patients presenting increased daytime sleepiness, with only two craniopharyngioma patients revealing a sleep related breathing disorder.
  • We speculate that secondary narcolepsy is an exacerbating condition of childhood craniopharyngioma obesity, supported by recent reports on orexin and narcolepsy which suggest hypothalamic failure in idiopathic narcolepsy.
  • [MeSH-major] Craniopharyngioma / complications. Narcolepsy / etiology. Obesity / complications. Pituitary Neoplasms / complications
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Central Nervous System Stimulants / therapeutic use. Child. Cohort Studies. Female. HLA Antigens / metabolism. Humans. Male. Polysomnography. Risk Factors. Sleep / physiology. Sleep Stages

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  • (PMID = 16700320.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 0 / HLA Antigens
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29. Zuccaro G: Radical resection of craniopharyngioma. Childs Nerv Syst; 2005 Aug;21(8-9):679-90
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  • [Title] Radical resection of craniopharyngioma.
  • INTRODUCTION: The best management of craniopharyngioma in children remains a controversial topic among neurosurgeons.
  • The two treatments for craniopharyngioma most commonly discussed in the literature are primary total resection and limited resection followed by radiotherapy.
  • Without ignoring the challenging behavior of these tumors, we strongly believe that the first approach in a child with a craniopharyngioma is to attempt total removal.
  • Trying to remove a craniopharyngioma that has been treated previously with other methods is, in our experience, much more dangerous because of adherences of the tumor to vascular and neural structures.
  • Among the 153 patients, the tumor was prechiasmatic in 35 and retrochiasmatic in 112; in ten, these were considered giant forms, and eight had a posterior fossa extension.
  • None of our patients regarded as having undergone total tumor resection disclosed recurrence after a follow-up of 1-16 years.
  • CONCLUSIONS: The treatment of choice in craniopharyngioma in childhood is total resection in order to avoid radiation therapy and recurrence.
  • [MeSH-major] Craniopharyngioma / therapy. Hypophysectomy / methods. Pituitary Irradiation. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Educational Status. Endocrine System Diseases / etiology. Female. Follow-Up Studies. Humans. Hydrocephalus / etiology. Infant. Infant, Newborn. Magnetic Resonance Imaging / methods. Male. Postoperative Complications. Retrospective Studies. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 16133275.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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30. Van Gompel JJ, Nippoldt TB, Higgins DM, Meyer FB: Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity. Neurosurg Focus; 2010 Apr;28(4):E3
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  • OBJECT: Obesity as a consequence of management of pediatric craniopharyngioma is a well-described phenomenon related to the degree of hypothalamic involvement.
  • Therefore, the purpose of this study was 1) to evaluate the pattern of postoperative weight gain related to preoperative body mass index (BMI), 2) determine if postoperative weight gain is an issue in adult patients, and 3) develop an objective MR imaging grading system to predict risk of postoperative weight gain and obesity in adults treated for craniopharyngioma.
  • METHODS: The authors retrospectively screened 296 patients with known craniopharyngioma for the following inclusion criteria: pathologically confirmed craniopharyngioma, index surgery at the authors' institution, and operative weight and height recorded with at least 3 months of follow-up including body weight measurement.
  • Comparing craniopharyngioma patients (cases) to age- and sex-matched controls, the preoperative BMIs were similar (p = 0.93) between cases (mean 28.9 [95% CI 30.9-26.9]) and controls (mean 29.3 [95% CI 31.9-26.7]).
  • CONCLUSIONS: Postoperative weight gain in adult patients undergoing surgery for craniopharyngioma is a significant problem and correlates with hypothalamic involvement, as it does in pediatric patients.
  • [MeSH-major] Craniopharyngioma / surgery. Magnetic Resonance Imaging / statistics & numerical data. Obesity / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis

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  • (PMID = 20367360.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024150
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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31. Müller HL, Bruhnken G, Emser A, Faldum A, Etavard-Gorris N, Gebhardt U, Kolb R, Sörensen N: Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma. Childs Nerv Syst; 2005 Nov;21(11):975-80
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  • [Title] Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma.
  • OBJECTS: We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
  • [MeSH-major] Craniopharyngioma / psychology. Hypophysectomy / psychology. Pituitary Neoplasms / psychology. Quality of Life / psychology. Survivors / psychology
  • [MeSH-minor] Activities of Daily Living / classification. Activities of Daily Living / psychology. Adolescent. Adult. Body Mass Index. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Female. Follow-Up Studies. Humans. Hypothalamus / pathology. Infant. Longitudinal Studies. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / psychology. Obesity / psychology. Pituitary Irradiation. Postoperative Complications / psychology. Psychometrics / statistics & numerical data. Radiotherapy, Adjuvant. Reproducibility of Results. Self-Assessment. Sickness Impact Profile

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  • (PMID = 16075216.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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32. Müller HL, Gebhardt U, Pohl F, Flentje M, Emser A, Warmuth-Metz M, Kolb R, Calaminus G, Sörensen N: Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma. Klin Padiatr; 2006 Nov-Dec;218(6):315-20
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  • [Title] Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma.
  • In HIT Endo data on therapy and prognosis of 306 patients with childhood craniopharyngioma (CP) were analyzed.
  • Monitoring of cerebral imaging and clinical status is recommended in follow-up of patients with childhood CP.
  • [MeSH-major] Craniopharyngioma / surgery. Neoplasm Recurrence, Local. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Disease Progression. Follow-Up Studies. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Multicenter Studies as Topic. Neoplasm, Residual. Prospective Studies. Radiotherapy Dosage. Reoperation. Surveys and Questionnaires. Survival Analysis. Time Factors

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  • (PMID = 17080333.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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33. Müller HL: Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up. Expert Rev Neurother; 2010 Apr;10(4):515-24
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  • [Title] Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up.
  • Craniopharyngiomas are embryogenic malformations of the sellar region of low histological malignancy, thought to be derived from Rathke's pouch epithelium.
  • With an overall incidence of 0.5-2.0 new cases per million of the population per year, 30-50% of all cases occur in childhood.
  • However, quality of survival is substantially reduced in many survivors, owing to long-term sequelae, such as extreme obesity caused by hypothalamic tumor involvement, which occurs in up to 40% of all cases.
  • The treatment of craniopharyngioma remains controversial.
  • Radical surgical strategies are associated with poor outcome in craniopharyngioma with hypothalamic involvement.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • (PMID = 20367205.001).
  • [ISSN] 1744-8360
  • [Journal-full-title] Expert review of neurotherapeutics
  • [ISO-abbreviation] Expert Rev Neurother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 56
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34. Kalina MA, Skala-Zamorowska E, Kalina-Faska B, Malecka-Tendera E, Mandera M: Practical approach to childhood craniopharyngioma: a role of an endocrinologist and a general paediatrician. Childs Nerv Syst; 2009 Sep;25(9):1053-60
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  • [Title] Practical approach to childhood craniopharyngioma: a role of an endocrinologist and a general paediatrician.
  • OBJECTIVES: The objectives of this study are to evaluate co-morbidities in patients with craniopharyngioma and to elaborate an interdisciplinary protocol of the follow-up.
  • CONCLUSIONS: On the grounds of these observations, the management of craniopharyngioma in our institution includes repeated hormonal and metabolic assays in chosen time intervals.
  • [MeSH-major] Craniopharyngioma / epidemiology. Craniopharyngioma / therapy

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  • (PMID = 19533152.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Hormones
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35. Di Battista E, Naselli A, Queirolo S, Gallarotti F, Garré ML, Milanaccio C, Cama A: Endocrine and growth features in childhood craniopharyngioma: a mono-institutional study. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:431-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine and growth features in childhood craniopharyngioma: a mono-institutional study.
  • OBJECTIVE: To evaluate growth and endocrine features in children with craniopharyngioma who were treated and followed up by a single institution between 1976 and 2004.
  • [MeSH-major] Craniopharyngioma / complications. Endocrine System Diseases / etiology. Growth Disorders / etiology. Pituitary Neoplasms / complications

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  • (PMID = 16700321.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hormones; 0 / Pituitary Hormones
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36. Tomita T, Bowman RM: Craniopharyngiomas in children: surgical experience at Children's Memorial Hospital. Childs Nerv Syst; 2005 Aug;21(8-9):729-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Craniopharyngioma during childhood poses difficulty in management because of the high incidence of surgical complications and treatment failure.
  • In order to identify less detrimental and more effective treatment, a personal series of craniopharyngioma was reviewed in regard to various clinical factors, patient factors (age and sex), tumor factors (location and extension, relationship with chiasm, and hydrocephalus), and therapeutic modes [extent of resection and radiation therapy (RT)].
  • MATERIALS AND METHODS: Fifty-four childhood craniopharyngiomas treated from 1984 to 2003 were reviewed.
  • Preoperative neuroimaging studies were classified depending upon tumor location and extension.
  • In this series of 54 patients, 43 had total tumor resection and 11 had subtotal resection.
  • Of the total resection group, ten showed evidence of residual tumor on postoperative neuroimaging studies.
  • Among the patients with total resection but radiographic residual and those with subtotal resection, the craniopharyngioma recurred in 90% and 100%, respectively.
  • The sex and age, location and extension of the tumor, nature of the optic chiasm, and hydrocephalus did not influence survival with statistical significance.
  • Patients who had subtotal resection or radiographically residual tumor without RT had a recurrence-free survival rate of only 9%.
  • Among 22 patients whose recurrent tumor was treated with RT, a second recurrence-free survival rate was 90% at 5 years.
  • However, recurrence rates and surgical complications remained high following radical tumor resection.
  • [MeSH-major] Craniopharyngioma / therapy. Hospitals. Pituitary Neoplasms / therapy

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  • (PMID = 16044343.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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37. Müller HL, Gebhardt U, Schröder S, Pohl F, Kortmann RD, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sörensen N, study committee of KRANIOPHARYNGEOM 2000/2007: Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr; 2010;73(3):175-80
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up.
  • BACKGROUND: Controversies surround various treatment variables for patients with childhood craniopharyngioma such as growth hormone (GH) replacement, which some believe can exacerbate recurrence/progression.
  • We prospectively assessed the risk of tumor recurrence/progression in survivors of childhood craniopharyngioma.
  • CONCLUSIONS: Tumor recurrences/progressions are frequent and occur early after initial treatment of childhood craniopharyngioma.
  • However, further conclusions on the influence of GH on recurrence rates have to be refined to long-term follow-up studies of patients with childhood craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Human Growth Hormone / therapeutic use. Humans. Infant. Male. Multivariate Analysis. Neoplasm Recurrence, Local / prevention & control. Prospective Studies. Risk Factors. Treatment Outcome

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20197669.001).
  • [ISSN] 1663-2826
  • [Journal-full-title] Hormone research in pædiatrics
  • [ISO-abbreviation] Horm Res Paediatr
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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38. Jung TY, Jung S, Moon KS, Kim IY, Kang SS, Kim JH: Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study. Pediatr Neurosurg; 2010;46(3):205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrinological outcomes of pediatric craniopharyngiomas with anatomical pituitary stalk preservation: preliminary study.
  • OBJECTIVE: We reviewed 17 pediatric craniopharyngioma patients, with a special focus on endocrinological outcomes and tumor recurrence with pituitary stalk preservation.
  • The overall tumor recurrence and re-growth rate were 52.9%.
  • CONCLUSIONS: Pediatric craniopharyngiomas had high recurrence rates and low pituitary functional preservation despite anatomical stalk preservation.
  • Therefore, maximal tumor resection might be more important than anatomical stalk preservation in pediatric craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma. Neoplasm Recurrence, Local / epidemiology. Neurosurgical Procedures / methods. Pituitary Gland / physiology. Pituitary Neoplasms

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20962554.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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39. Müller HL: Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up. Nat Rev Endocrinol; 2010 Nov;6(11):609-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up.
  • Craniopharyngiomas have an overall incidence of 0.5-2.0 new cases per million of the population per year, and ∼30-50% of all cases represent childhood craniopharyngioma.
  • Total resection is the treatment of choice in patients with favorable tumor localization, with the intention to maintain hypothalamic-pituitary and optical nerve functions.
  • When the tumor localization is unfavorable, a limited resection followed by local irradiation is recommended.
  • Irradiation of the tumor is protective and the appropriate time point of irradiation after incomplete resection is currently under investigation in a randomized trial.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Growth Disorders. Headache. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / epidemiology. Obesity / epidemiology. Obesity / surgery. Polyuria. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Vision Disorders

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  • (PMID = 20877295.001).
  • [ISSN] 1759-5037
  • [Journal-full-title] Nature reviews. Endocrinology
  • [ISO-abbreviation] Nat Rev Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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40. Crom DB: Metabolic abnormalities in an adult survivor of pediatric craniopharyngioma. Oncology (Williston Park); 2008 Jul;22(8 Suppl Nurse Ed):43-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metabolic abnormalities in an adult survivor of pediatric craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / complications. Craniopharyngioma / nursing. Endocrine System Diseases / etiology. Endocrine System Diseases / nursing. Pituitary Neoplasms / complications. Pituitary Neoplasms / nursing

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  • (PMID = 19856572.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Müller HL: More or less? Treatment strategies in childhood craniopharyngioma. Childs Nerv Syst; 2006 Feb;22(2):156-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] More or less? Treatment strategies in childhood craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy

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  • [CommentOn] Childs Nerv Syst. 2006 Feb;22(2):151-5; discussion 158-63 [16320025.001]
  • [Cites] Klin Padiatr. 2003 Nov-Dec;215(6):310-4 [14677094.001]
  • [Cites] Childs Nerv Syst. 2005 Nov;21(11):975-80 [16075216.001]
  • (PMID = 16320024.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Germany
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42. Müller HL, Albanese A, Calaminus G, Hargrave D, Garré ML, Gebhardt U, Saran F, Sörensen N, Spoudeas HA: Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:453-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy

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  • (PMID = 16700324.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] England
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