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1. Ahmed M, Bin Yousef H, Greer W, Faraz H, Al Sobhi S, Al Zahrani A, Raef H, Al Ghamdi A, Al Kadhi Y, Al Dayel F: Hurthle cell neoplasm of the thyroid gland. ANZ J Surg; 2008 Mar;78(3):139-43
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  • [Title] Hurthle cell neoplasm of the thyroid gland.
  • BACKGROUND: A clinicopathological analysis and long-term follow up of 32 patients with Hurthle cell neoplasm (HCN) was undertaken to contrast the clinical and histological features between benign versus malignant HCN of thyroid and to examine the effect of treatment on the outcome.
  • RESULTS: Seventeen patients were classified as malignant HCN (MHCN) and 15 as benign HCN (BHCN).
  • The mean tumour size was 4.43 +/- 0.66 cm for MHCN, and 2.57 +/- 0.32 cm for BHCN (P = 0.03).
  • Multicentric tumour foci were evident in five cases (29%) of MHCN but none among the BHCN (P = 0.03).
  • At neck exploration cervical lymph node dissection was carried out in nine MHCN patients with findings of tumour metastases in 33%.
  • CONCLUSION: Features of MHCN consisted of a large tumour size, unequivocal capsular and vascular invasion, multicentric tumour foci, metastatic lymph node deposits in one-third of patients and presence of distant metastasis in a few.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Registries. Retrospective Studies. Risk Assessment. Survival Analysis. Thyroidectomy / methods. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2008 Mar;78(3):115 [18269467.001]
  • (PMID = 18269475.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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2. Ferlito A, Devaney KO, Rinaldo A: Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor. Acta Otolaryngol; 2006 Mar;126(3):228-31
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  • [Title] Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor.
  • The concept of a carcinoid tumor in the gastrointestinal tract and lung is well established; less often, patients develop carcinoid tumors in the head and neck region.
  • Middle ear carcinoids have previously been approached as benign entities, lacking any capacity for metastasizing.
  • A critical review of the literature, however, disclosed a small number of cases in which middle ear carcinoid tumors have given rise to regional (cervical node) metastases.
  • [MeSH-major] Carcinoid Tumor / secondary. Ear Neoplasms / pathology. Ear, Middle. Lymphatic Metastasis / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 16618645.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 21
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3. Canis M, Farina M, Jardon K, Rabischong B, Rivoire C, Nohuz E, Botchorishvili R, Pouly JL, Mage G: [Laparoscopy and gynecologic cancer in 2005]. J Gynecol Obstet Biol Reprod (Paris); 2006 Apr;35(2):117-35
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  • [Transliterated title] Coelioscopie et cancer en gynécologie: le point en 2005.
  • Animal studies suggested that the risk of tumor dissemination in non traumatized peritoneum is higher after a pneumoperitoneum than after a laparotomy.
  • Changing these parameters we may, in the future, be able to create a peritoneal environment adapted to oncologic patients in order to prevent or to decrease the risks of peritoneal dissemination and/or of postoperative tumor growth.
  • In patients with endometrial cancer, the laparoscopic approach should be reserved to clinical stage I disease, if the vaginal extraction is anticipated to be easy accounting for the volume of the uterus and the local conditions.
  • In cervical cancer, the laparoscopic approach should be reserved to patients with favorable prognostic factors: stage IB of less than 2 cm in diameter.
  • Laparoscopy is the gold standard for the surgical diagnosis of adnexal masses.
  • In contrast restaging of an early ovarian cancer initially managed as a benign mass, is a good indication of the laparoscopic approach.
  • [MeSH-major] Genital Neoplasms, Female / surgery. Laparoscopy
  • [MeSH-minor] Animals. Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. Female. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / epidemiology. Peritoneal Neoplasms / etiology. Pneumoperitoneum, Artificial / adverse effects. Risk Factors. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / surgery

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  • (PMID = 16575358.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 190
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4. Ponce-Camacho MA, Diaz de Leon-Medina R, Miranda-Maldonado I, Garza-Guajardo R, Hernandez-Salazar J, Barboza-Quintana O: A 5-year-old girl with a congenital ganglioneuroma diagnosed by fine needle aspiration biopsy: a case report. Cytojournal; 2008;5:5
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  • INTRODUCTION: Ganglioneuroma is a rare, benign, neuroblastic tumor arising mainly from the central or peripheral autonomic nervous system, especially the sympathetic system.
  • CASE PRESENTATION: A 5-year-old girl presented with a mass in the cervical region since birth.
  • Laboratory routine tests were within normal limits, ultrasonography demonstrated a solid and well-circumscribed lesion in the soft tissues of the cervical region.
  • A diagnosis of ganglioneuroma was suggested.
  • Core biopsy and surgical resection confirmed this diagnosis.
  • CONCLUSION: Congenital ganglioneuroma of the cervical region is an uncommon soft tissue benign neoplasm of neuroblastic origin, and it should be considered in the differential diagnosis of head and neck pediatric soft tissue tumors.

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  • (PMID = 18373875.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359765
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5. Schmidt M, Dietlein M, Schröder U, Schicha H: False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin Nucl Med; 2006 Nov;31(11):716-7
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  • Neither thyroid remnant tissue nor enlarged cervical lymph nodes could be demonstrated either on CT or on MRI.
  • Further examination of the patient in the ear, nose and throat department confirmed the finding of a laryngocele and biopsies demonstrated benign tissue.
  • The patient declined definitive operative revision of the laryngocele and is in good health 8 years after the diagnosis of papillary thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary / radionuclide imaging. Iodine Radioisotopes. Laryngeal Diseases / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging
  • [MeSH-minor] Aged. Diagnosis, Differential. False Positive Reactions. Female. Humans. Radiopharmaceuticals / therapeutic use. Thyroidectomy

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  • (PMID = 17053394.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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6. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • The average recover ratio of total was (46.7 +/- 2.46)%, cervical stability was (62.37 +/- 3.58)%, the other methods was (41.21 +/- 4.63)%.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.
  • MRI is regarded the effective method which is helpful in differential diagnosis and surgery guidance.
  • [MeSH-major] Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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7. Jozwik M, Szajda SD, Skrzydlewski Z, Jozwik M, Sulkowski S: The activity of cancer procoagulant in cases of uterine leiomyomas. Eur J Gynaecol Oncol; 2005;26(4):407-10
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  • [Title] The activity of cancer procoagulant in cases of uterine leiomyomas.
  • The present study was designed to test whether it is also synthesized by benign neoplastic cells, namely uterine leiomyomas.
  • MATERIALS AND METHODS: We determined the activity of CP in the blood serum of women with uterine leiomyomas (N = 24), normal women (N = 15), and genital cancer patients (N = 6) by the coagulative method according to Gordon and Benson.
  • Also, the CP activity in 10% tissue homogenates of uterine leiomyomas, normal uterine muscle and tissues of cervical and endometrial carcinoma was determined by the chromogenic method according to Colucci et al.
  • RESULTS: The mean CP activity in the sera of women with uterine leiomyomas was 181.1 seconds (s) +/- 19.9 s, in healthy women--293.2 s +/- 33.8 s, and in genital cancer patients--78.8 +/- 18.5 s (all differences: p < 0.001).
  • Similarly, in homogenates of uterine leiomyomas the CP activity was 19.6 +/- 3.8 nmoles pNa/ml, in normal uterine muscle it was 13.2 +/- 2.2 nmoles pNa/ml, and in cancerous tissue--28.0 +/- 6.6 nmol pNa/ml (all values being significantly different from each other).
  • There was a strong correlation (r = -0.8122; p < 0.001) between the CP activity in uterine leiomyomas and serum activity, suggesting that the source of the serum CP activity was from the leiomyoma.
  • The coagulation time of 120 to 240 s by the Gordon and Benson method supported the diagnosis of uterine leiomyoma, and a value below 120 s--the suspicion of genital cancer.
  • CONCLUSIONS: Uterine leiomyomas, representing benign genital neoplasia, synthesize CP and are the likely origin of CP activity in blood, as has been described for malignant tumors, but to a lesser degree.
  • There may be a role for CP as a tumor marker of genital neoplasia.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cysteine Endopeptidases / biosynthesis. Leiomyoma / diagnosis. Neoplasm Proteins / analysis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / blood. Genital Neoplasms, Female / chemistry. Genital Neoplasms, Female / diagnosis. Humans. Middle Aged. Pilot Projects

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  • (PMID = 16122189.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.26 / cancer procoagulant
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8. Kalyanasundaram K, Ganesan R, Perunovic B, McCluggage WG: Diffusely infiltrating endometrial carcinomas with no stromal response: report of a series, including cases with cervical and ovarian involvement and emphasis on the potential for misdiagnosis. Int J Surg Pathol; 2010 Apr;18(2):138-43
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  • [Title] Diffusely infiltrating endometrial carcinomas with no stromal response: report of a series, including cases with cervical and ovarian involvement and emphasis on the potential for misdiagnosis.
  • Endometrial carcinomas, particularly of endometrioid type, can invade the myometrium or cervix without eliciting a stromal desmoplastic or inflammatory response and have been referred to as diffusely infiltrating endometrial carcinomas.
  • The neoplasms consisted of 12 endometrioid carcinomas, 1 mixed endometrioid and clear cell carcinoma, and 1 serous carcinoma.
  • Seven cases exhibited cervical stromal involvement and in 2 there was involvement of both ovaries in a similar pattern.
  • Several of the cases were seen in consultation and the pattern of infiltration raised a number of differential diagnoses, both benign and malignant, depending on the site of tumor involvement, including adenomyosis, adenomyoma, primary endocervical glandular lesions, cervical mesonephric remnants, endometriosis or tuboendometrioid metaplasia, and ovarian cortical inclusion cysts.
  • [MeSH-major] Adenocarcinoma / pathology. Endometrial Neoplasms / pathology. Ovarian Neoplasms / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnostic Errors / prevention & control. Female. Humans. Middle Aged. Myometrium / pathology. Neoplasm Invasiveness. Stromal Cells / pathology


9. Kumasaka T, Seyama K, Mitani K, Souma S, Kashiwagi S, Hebisawa A, Sato T, Kubo H, Gomi K, Shibuya K, Fukuchi Y, Suda K: Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. Am J Surg Pathol; 2005 Oct;29(10):1356-66
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  • Recent studies indicate that LAM cells can migrate or metastasize to form new lesions in multiple organs, although they show a morphologically benign appearance.
  • We identified LAM lesion in the diaphragm (2 of 5 autopy cases and one surgical specimen), thoracic duct (5 of 5), and lymph nodes (retroperitoneal (5 of 5), mediastinal (4 of 5), left venous angle (5 of 5) with total positive rate of 68% to 88% at each region of the lymph node, but less frequent or none at remote lymph nodes located away from the axial lymph trunk (cervical [1 of 5] and axillary [0 of 5]).
  • [MeSH-major] Endothelial Cells / pathology. Lymphangiogenesis. Lymphangioleiomyomatosis / pathology. Neoplasm Metastasis / pathology. Neoplastic Cells, Circulating / pathology


10. Wang X, Kumar D, Seidman JD: Uterine lipoleiomyomas: a clinicopathologic study of 50 cases. Int J Gynecol Pathol; 2006 Jul;25(3):239-42
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  • [Title] Uterine lipoleiomyomas: a clinicopathologic study of 50 cases.
  • Lipoleiomyoma is an uncommon uterine neoplasm and, although presumed to be benign, has been inadequately studied.
  • Confirming the benign nature of this tumor is important because it can closely resemble well-differentiated liposarcoma.
  • We evaluated 50 consecutive lipoleiomyomas diagnosed at the Washington Hospital Center from 1998 to 2004; 2.1% of patients who had uterine leiomyomas during this period had a lipoleiomyoma.
  • The mean and median tumor size was 4.6 and 2.1 cm, respectively.
  • Forty-three (83%) tumors were located in the uterine corpus, and 7 (13%) were in the cervix.
  • One broad ligament tumor and one retroperitoneal tumor were also studied.
  • There were no recurrences or fatalities related to tumor.
  • Lipoleiomyoma of the uterus seems to have an uneventful clinical course and can now be confidently regarded as benign.
  • [MeSH-major] Leiomyoma / pathology. Lipoma / pathology. Uterine Cervical Neoplasms / pathology. Uterine Neoplasms / pathology


11. Chang X, Han J, Pang L, Zhao Y, Yang Y, Shen Z: Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer; 2009;9:40
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  • METHODS: Expression of PADI4 was investigated in various tumors and non-tumor tissues (n = 1673) as well as in A549, SKOV3 and U937 tumor cell lines by immunohistochemistry, real-time PCR, and western blot.
  • RESULTS: Immunohistochemistry detected significant PADI4 expression in various malignancies including breast carcinomas, lung adenocarcinomas, hepatocellular carcinomas, esophageal squamous cancer cells, colorectal adenocarcinomas, renal cancer cells, ovarian adenocarcinomas, endometrial carcinomas, uterine adenocarcinomas, bladder carcinomas, chondromas, as well as other metastatic carcinomas.
  • However, PADI4 expression was not observed in benign leiomyomas of stomach, uterine myomas, endometrial hyperplasias, cervical polyps, teratomas, hydatidiform moles, trophoblastic cell hyperplasias, hyroid adenomas, hemangiomas, lymph hyperplasias, schwannomas, neurofibromas, lipomas, and cavernous hemangiomas of the liver.
  • Additionally, PADI4 expression was not detected in non-tumor tissues including cholecystitis, cervicitis and synovitis of osteoarthritis, except in certain acutely inflamed tissues such as in gastritis and appendicitis.
  • Furthermore, western blot analysis detected PADI4 expression in cultured tumor cell lines.
  • ELISA detected increased PADI4 and cAT levels in the blood of patients with various malignant tumors compared to those in patients with chronic inflammation and benign tumors.
  • Additionally, PADI4 and cAT levels were significantly associated with higher levels of known tumor markers.
  • [MeSH-major] Hydrolases / metabolism. Neoplasm Proteins / metabolism. Neoplasms / metabolism
  • [MeSH-minor] Antithrombins / metabolism. Blotting, Western. Cell Line, Tumor. Citrulline / metabolism. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunohistochemistry. Immunoprecipitation. Male. Polymerase Chain Reaction / methods

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  • (PMID = 19183436.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithrombins; 0 / Neoplasm Proteins; 29VT07BGDA / Citrulline; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
  • [Other-IDs] NLM/ PMC2637889
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12. Haberal A, Cil AP, Gunes M, Cavusoglu D: Papillary adenofibroma of the cervix: a case report. Ultrasound Obstet Gynecol; 2005 Aug;26(2):186-7
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  • [Title] Papillary adenofibroma of the cervix: a case report.
  • Adenofibroma is an extremely rare benign biphasic neoplasm that is classified into the mixed epithelial and mesenchymal tumor group.
  • It typically affects the endometrium, but may occur in the cervix or in an extrauterine location.
  • Preoperative diagnosis of this tumor is usually difficult.
  • We describe the case of a 55-year-old woman with papillary cervical adenofibroma, which appeared as a cervical mass containing multiple cystic components on transvaginal ultrasound.
  • This lesion appears to be clinically and histologically benign but must be differentiated from malignant lesions of the uterus, particularly from adenosarcoma, which can be suggestive of adenofibroma.
  • Accurate diagnosis of these benign tumors permits appropriate counseling of patients.
  • [MeSH-major] Adenofibroma / ultrasonography. Uterine Cervical Neoplasms / ultrasonography


13. Kruse AL, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol; 2009;1:31
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  • BACKGROUND: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla.
  • Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site.
  • In 54% the primary diagnosis was ameloblastic carcinoma, 34.6% revealed pulmonary metastases, however, only in one patient cervical lymph node metastasis could be found.
  • Nineteen of 26 patients (73,1%) were controlled during a median follow-up time of 54,3 months (6 to 156 months); 6 patients died of disease after a median time of 62,7 months (7 to 156 months) after initial diagnosis.
  • [MeSH-major] Ameloblastoma / classification. Maxillary Neoplasms / classification
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Evidence-Based Medicine. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19674470.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2733136
  • [General-notes] NLM/ Original DateCompleted: 20100629
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14. Honig A, Weidler C, Häusler S, Krockenberger M, Buchholz S, Köster F, Segerer SE, Dietl J, Engel JB: Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer. Anticancer Res; 2010 May;30(5):1559-64
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  • [Title] Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.
  • The current study investigated the expression of BMI-I in human specimens of breast, ovarian, endometrial and cervical cancer.
  • BMI-I expression in human specimens of breast, endometrial and cervical cancer was evaluated by IHC and then compared with the respective benign tissues.
  • RESULTS: BMI-I was significantly (p<0.05) overexpressed in human breast, ovarian, endometrial and cervical cancer specimens as compared to benign controls.
  • In human breast cancer samples, BMI-I expression was most pronounced in the invasion front of the tumour.
  • CONCLUSION: The current study showed for the first time that the BMI-I protein is significantly overexpressed in ovarian, endometrial and cervical cancer and may thus be a potential target for novel antitumor therapies.
  • [MeSH-major] Breast Neoplasms / metabolism. Endometrial Neoplasms / metabolism. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Nuclear Proteins / biosynthesis. Nuclear Proteins / physiology. Ovarian Neoplasms / metabolism. Proto-Oncogene Proteins / biosynthesis. Proto-Oncogene Proteins / physiology. Repressor Proteins / biosynthesis. Repressor Proteins / physiology. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Antineoplastic Agents / pharmacology. Cell Differentiation. Female. Humans. Immunohistochemistry / methods. Ki-67 Antigen / biosynthesis. Neoplasm Proteins / metabolism. Phenotype. Polycomb Repressive Complex 1


15. Upile T, Triaridis S, Kirkland P, Goldstraw P, Rhys Evans P: How we do it: the anterior thoraco-cervical approach to tumours of the thoracic inlet. Clin Otolaryngol; 2005 Dec;30(6):561-5
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  • [Title] How we do it: the anterior thoraco-cervical approach to tumours of the thoracic inlet.
  • KEYPOINTS: Tumours that arise in the thoracic inlet and superior mediastinum may be benign or malignant and present the surgeon with a difficult problem of access.
  • The anterior thoraco-cervical approach to the root of the neck and superior mediastinum combines the anterior cervical approach with a limited upper median sternotomy.
  • The approach offers excellent exposure and helps to facilitate complete resection of benign and malignant tumours, which would otherwise be deemed inoperable or difficult to resect completely through other standard approaches.
  • In contrast to previously described anterior transcervical thoracic approaches which required resection of part of the clavicle or manubrium as well as thoracotomy with increased morbidity, the anterior thoraco-cervical approach is associated with little morbidity and the postoperative stay is short.
  • [MeSH-major] Neck / surgery. Thoracic Neoplasms / surgery. Thoracotomy / methods
  • [MeSH-minor] Chylothorax / etiology. Dissection. Follow-Up Studies. Humans. Mediastinal Neoplasms / surgery. Mediastinum / surgery. Neck Muscles / surgery. Neoplasm Metastasis. Neoplasm Recurrence, Local / surgery. Pleural Effusion / etiology. Postoperative Complications. Postoperative Hemorrhage / etiology. Sternum / surgery. Treatment Outcome

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  • (PMID = 16402986.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Zarei F, Iranpour P: Pneumatocyst, mimicking a sclerotic bony lesion on magnetic resonance imaging. Spine J; 2010 Apr;10(4):e17-9
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  • BACKGROUND CONTEXT: Intravertebral pneumatocyst is an uncommon benign lesion, not related to conditions, such as osteomyelitis and postsurgical state, with only a few cases reported in the literature.
  • PURPOSE: The purpose of the study was to report a case of cervical pneumatocyst resembling a sclerotic lesion on magnetic resonance imaging (MRI) and review of literature.
  • RESULTS: Cervical spine MRI revealed a low signal bony lesion on T1 and T2 images.
  • Considering the signal characteristics, initial diagnosis of sclerosis was made.
  • Reviewing the cervical X-ray, a round faint lytic lesion was detected.
  • Correlation with cervical computed tomography scan showed the lesion being of air density, compatible with the diagnosis of pneumatocyst.
  • CONCLUSION: Intraosseous pneumatocyst of cervical spine is a benign finding, which needs no specific treatment; however, it must be included in the differential diagnosis of lucent vertebral lesions seen on conventional radiography and should be differentiated from bony neoplasm and osteomyelitis by its characteristic imaging findings.
  • [MeSH-major] Bone Cysts / pathology. Cervical Vertebrae / pathology. Magnetic Resonance Imaging. Neck Pain / pathology. Spinal Diseases / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Gases. Humans. Middle Aged. Paresthesia / pathology. Tomography, X-Ray Computed

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  • (PMID = 20362243.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gases
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17. Brooks RA, Wright JD, Powell MA, Rader JS, Gao F, Mutch DG, Wall LL: Long-term assessment of bladder and bowel dysfunction after radical hysterectomy. Gynecol Oncol; 2009 Jul;114(1):75-9
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  • METHODS: Subjects included women who underwent radical hysterectomy for early stage cervical cancer between 1993 and 2003.
  • Two contemporary controls who underwent extrafascial abdominal hysterectomy for benign disease were identified for each subject.
  • [MeSH-major] Hysterectomy / adverse effects. Intestinal Diseases / etiology. Urinary Bladder Diseases / etiology. Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Emotions. Female. Humans. Life Style. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome. Urinary Incontinence / epidemiology. Urinary Incontinence / etiology


18. Sarda AK, Kapur MM: Thyroid surgery in an area of iodine deficiency. Head Neck; 2005 May;27(5):383-9
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  • The indications for surgery were hyperthyroidism or cytologically diagnosed malignancy and large size, pressure symptoms, cosmesis, suspicious cytologic findings for malignancy, and clinical suspicion of malignancy in clinically benign euthyroid goiters.
  • RESULTS: Histologically, 83 of 703 solitary thyroid nodules, 36 of 329 clinically benign euthyroid multinodular goiters, and four of 181 Graves' disease were cancers.
  • The different histologic types exhibited an aggressive clinical behavior, with advanced lesions with cervical lymph node involvement and distant metastases frequently seen at presentation.
  • [MeSH-major] Catchment Area (Health). Goiter, Nodular / surgery. Iodine / deficiency. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Follicular / epidemiology. Adenocarcinoma, Follicular / surgery. Adenocarcinoma, Papillary / epidemiology. Adenocarcinoma, Papillary / surgery. Adult. Female. Follow-Up Studies. Humans. India / epidemiology. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Thyroidectomy / adverse effects. Thyroidectomy / methods. Thyrotropin / blood

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15772954.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; 9679TC07X4 / Iodine
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19. Mikami Y, Kiyokawa T, Moriya T, Sasano H: Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining. Histopathology; 2005 Feb;46(2):130-6
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  • AIMS: To define the phenotypic alteration of the stromal component in association with destructive invasion which is a crucial feature in distinguishing minimal deviation adenocarcinoma (MDA) from benign endocervical glandular lesions.
  • METHODS AND RESULTS: We studied endocervical glandular hyperplasias including non-specific-type (NEGH) (n = 3) and lobular-type (LEGH) (n = 8), and minimal deviation adenocarcinoma (MDA) (n = 11), well-differentiated endocervical adenocarcinoma of usual-type (WDA) (n = 11), and adenocarcinoma in situ (AIS) (n = 6) of the cervix, by double immunostaining for oestrogen receptor (ER) and alpha-smooth muscle actin (alpha-SMA) using peroxidase- and alkaline phosphatase-polymer methods, respectively.
  • [MeSH-major] Actins / analysis. Adenocarcinoma / pathology. Cervix Uteri / pathology. Receptors, Estrogen / analysis. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Hyperplasia. Immunohistochemistry / methods. Metaplasia. Muscle, Smooth / chemistry. Neoplasm Invasiveness


20. Cuschieri K, Wentzensen N: Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev; 2008 Oct;17(10):2536-45
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  • [Title] Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia.
  • Human papillomavirus (HPV) infection of the genital tract is very common and normally follows a benign clinical course; however, in an unfortunate minority of infected individuals, it can cause disease that sometimes leads to cancer.
  • It is accepted that HPV DNA testing has a role in the management of cervical disease both in a prevaccination and postvaccination era; however, to improve the specificity of this approach, there is a requirement to develop and validate tools/assays that can identify women at risk for progressive disease.
  • Currently, there is promising data indicating that HPV mRNA and p16 might play an important role in future cervical cancer screening scenarios.
  • METHODS: PubMed and OVID were interrogated with search terms "HPV RNA;" "HPV mRNA;" "HPV transcript-detection, testing, and methods;" "p16" AND "cervical cancer;" "p16" AND "CIN;" "p16" AND "histology"; "p16" AND "cytology;" "p16;" and "screening. "
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasm Proteins / genetics. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis. RNA, Messenger / analysis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Mass Screening / methods. Precancerous Conditions / diagnosis. Precancerous Conditions / genetics. Precancerous Conditions / virology

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  • (PMID = 18842994.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010124-14
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / RNA, Messenger
  • [Number-of-references] 89
  • [Other-IDs] NLM/ NIHMS212843; NLM/ PMC2900792
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21. Otoh EC, Johnson NW, Olasoji H, Danfillo IS, Adeleke OA: Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):386-91
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  • [Title] Salivary gland neoplasms in Maiduguri, north-eastern Nigeria.
  • OBJECTIVE: To document the pattern of salivary gland neoplasia in Maiduguri, Nigeria.
  • MATERIALS AND METHODS: Information on demographics, diagnosis and cancer management in the hospital were retrieved from biopsy reports and case notes of patients.
  • RESULTS: The palatal (71.9%) and parotid (78.3%) glands were the most common minor and major salivary glands involved, with a benign-malignant ratio of 1:1 and 1.4:1, respectively.
  • Pleomorphic adenoma (44.3%) was the most common salivary gland neoplasm recorded.
  • Ectopic lesions (17.1%) were reported in the neck, nose and cervical nodes.
  • CONCLUSION: Pleomorphic adenoma and mucoepidermoid carcinoma were the most commonly reported benign and malignant neoplasia in this series.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Palatal Neoplasms / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Female. Humans. Male. Middle Aged. Nigeria / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Sex Distribution

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  • (PMID = 16269031.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 30
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22. Junming M, Cheng Y, Dong C, Jianru X, Xinghai Y, Quan H, Wei Z, Mesong Y, Dapeng F, Wen Y, Bin N, Lianshun J, Huimin L: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976); 2008 Feb 1;33(3):280-8
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  • [Title] Giant cell tumor of the cervical spine: a series of 22 cases and outcomes.
  • STUDY DESIGN: A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003.
  • OBJECTIVE: This study reviews the clinical patterns and follow-up data of (GCT) of bone arising in the cervical spine which underwent surgical treatment.
  • SUMMARY OF BACKGROUND DATA: GCTs of bone are common, aggressive, or low-grade malignant tumors that occur infrequently in the spine above the sacrum, and their presence in the cervical vertebrae is even more exceptional.
  • Though surgical resection of GCT arising in the cervical spine is commonly regarded as a recommended treatment method, it is still a challenge to achieve satisfactory results, especially for the late or recurrent cases, and there are few large series of cases reported with long-term follow-up of this tumor that are found in special segments in the literature.
  • METHODS: All clinical and follow-up data of 22 cases of GCT arising in cervical spine which received surgical treatment in our spine center from January 1990-December 2003 were collected.
  • One special lesion located in the posterior element of C7 received "en bloc" resection.
  • For reconstructing the stability of the cervical spine, we used autologous ilium for pure bone graft, or titanium plate and titanium mesh for anterior instrumented fusion or anterior and posterior combined instrumented fusion.
  • RESULTS: One patient with C1-C2 GCT (vertebral body and posterior element involvement) who received subtotal resection of the tumor showed aggravation of neurologic deficit and died shortly after the surgery.
  • CONCLUSION: GCT of the cervical spine easily onsets between 20 and 40 years of age.
  • As a kind of benign but local aggressive or low potential malignancy tumor, we should take an aggressive attitude to excise the tumor as much as possible while reserving the neural function as a precondition.
  • Unlike in the thoracic and lumbar spine, a strictly "en bloc" resection is often not a feasible option because of the involvement of critical neurovascular structures.
  • [MeSH-major] Bone Neoplasms / surgery. Cervical Vertebrae / surgery. Giant Cell Tumor of Bone / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Diskectomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Postoperative Complications. Spinal Fusion. Survival Rate. Treatment Outcome


23. Yannopoulos P, Theodoridis P, Manes K: Esophagectomy without thoracotomy: 25 years of experience over 750 patients. Langenbecks Arch Surg; 2009 Jul;394(4):611-6
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  • PATIENTS AND METHODS: This is a retrospective analysis of all THE operations performed between January 1981 until May 2007 in 750 patients: 60 patients (8%) had benign lesions, while 690 (92%) had malignant ones (5.2% of malignancies were located in the upper esophagus, 7.4% in the middle esophagus, 19% in the lower esophagus, and 68.4% at the cardioesophageal junction).
  • We believe that our strategies concerning the way of dissecting the cervical esophagus, avoidance of performing pyloromyotomy, the delayed removal of the cervical drain and the delayed advance to oral feeding have reduced, noticeably, morbidity and mortality in our series.

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  • [Cites] World J Surg. 2001 Feb;25(2):196-203 [11338022.001]
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  • (PMID = 19350267.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2687514
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24. Abiko K, Baba T, Ogawa M, Mikami Y, Koyama T, Mandai M, Konishi I: Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpus. Pathol Int; 2010 Jan;60(1):42-7
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  • [Title] Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpus.
  • Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms.
  • In some areas endometrial glands of adenomyosis were replaced by benign-looking mucinous metaplasia.
  • The uterine cervix showed no abnormalities.
  • HIK1083 and MUC6 immunohistochemistry indicated a gastric phenotype of the tumor, as seen in cases of prototypical minimal deviation adenocarcinoma (MDA) of the cervix.
  • In summary, mucinous endometrial adenocarcinoma rarely shows features similar to MDA of the cervix.
  • This case provokes a discussion on diagnostic and management strategy, and histogenesis of mucinous neoplasm of the endometrium.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Uterine Cervical Neoplasms / pathology. Uterine Neoplasms / pathology


25. Singh AM, Konjengbam R, Devi SS, Devi NP: Leiomyosarcoma of uterus--a case report. J Indian Med Assoc; 2006 Mar;104(3):142, 144, 147
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  • [Title] Leiomyosarcoma of uterus--a case report.
  • Leiomyosarcoma of uterus is a very rare malignant mesenchymal tumour of uterus.
  • It may arise from the uterine myometrium de novo or may be transformed from a pre-existing benign leiomyoma.
  • A 55-year-old female presenting with 20-22 weeks size of uterus and bleeding per vagina was clinically diagnosed as a case of leiomyoma uteri and cervical polyp, was subjected to abdominal hysterectomy.
  • The tumour mass was later confirmed histologically as leiomyosarcoma of uterus presumed to be transformed from pre-existing leiomyoma uteri.
  • [MeSH-major] Hysterectomy. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 16910338.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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26. Novosel T, Ritter HE, Gupta M, Harvey A, Mitchell J, Berber E, Siperstein A, Milas M: Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas. Surgery; 2009 Dec;146(6):1081-9
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  • BACKGROUND: Circulating thyroid cancer cells detected by peripheral blood thyroid-stimulating hormone receptor (TSHR) mRNA have demonstrated usefulness for thyroid cancer diagnosis and long-term surveillance.
  • METHODS: We compared clinical characteristics of 37 patients with papillary thyroid microcarcinomas (PTMC; tumor size </=1 cm) having undetectable (-) versus detectable (+)TSHR mRNA.
  • RESULTS: 59 Of the PTMC patients, 59% had (+)TSHR mRNA levels, similar to those with tumors >1 cm (72%; P = NS) and distinctly higher than false (+) rates in benign goiters (15%; P < .001).
  • Mean tumor size (5 mm) and multifocality rates (45%) were similar in both mRNA groups.
  • Of the PTMC patients, 35% had concurrent cervical nodal metastases, which occurred more frequently with tumors >/=5 mm (P = .04) and with (+)TSHR mRNA in pre-operatively known PTMC (P < .05).
  • [MeSH-major] Carcinoma, Papillary / blood. Carcinoma, Papillary / secondary. Neoplastic Cells, Circulating / pathology. Thyroid Neoplasms / blood. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis / genetics. Lymphatic Metastasis / pathology. Male. Middle Aged. Prospective Studies. RNA, Messenger / blood. RNA, Messenger / genetics. RNA, Neoplasm / blood. RNA, Neoplasm / genetics. Receptors, Thyrotropin / genetics. Young Adult


27. Seidman JD, Kumar D, Cosin JA, Winter WE 3rd, Cargill C, Boice CR: Carcinomas of the female genital tract occurring after pelvic irradiation: a report of 15 cases. Int J Gynecol Pathol; 2006 Jul;25(3):293-7
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  • Ten were irradiated for cervical cancer, one for endometrial carcinoma, one for vulvar carcinoma, one for colon cancer and 2 for benign conditions.
  • The "postradiation" malignancies included 2 ovarian carcinomas, 5 vaginal carcinomas (3 invasive, 2 in situ), 4 endometrial carcinomas, one cervical carcinoma, one vulvar carcinoma, one distal urethral carcinoma, and one pelvic carcinoma of unclear primary site.
  • [MeSH-major] Carcinoma / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Radiation-Induced / pathology. Pelvis / radiation effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16810069.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Bhandarkar ND, Sims HS, David O: ProEx C stain analysis in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol; 2010 Feb;119(2):99-104
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  • OBJECTIVES: We evaluated the presence and pattern of ProEx C stain, a marker for the proliferative capacity of cells, in laryngeal tissues, including benign, malignant, and recurrent respiratory papilloma (RRP) specimens, and compared it to hematoxylin and eosin staining for the presence of dysplasia.
  • RESULTS: A total of 26 specimens (9 benign, 7 malignant, 10 RRP) representing 21 patients were stained.
  • ProEx C stained positive in the nuclei of laryngeal tissue, consistent with its localization in cervical cytology specimens.
  • Seven of 9 benign and 7 of 10 RRP specimens stained positive.
  • The benign specimens were mostly polyps.
  • In benign and RRP specimens, the basal layer typically stained positive.
  • Other areas of epithelium stained weakly in benign specimens and variably in RRP specimens.
  • [MeSH-major] Antigens, Neoplasm / analysis. Cell Cycle Proteins / analysis. DNA Topoisomerases, Type II / analysis. DNA-Binding Proteins / analysis. Nuclear Proteins / analysis. Papilloma / chemistry. Respiratory Tract Neoplasms / chemistry
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Isoenzymes. Minichromosome Maintenance Complex Component 2. Neoplasm Recurrence, Local

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  • (PMID = 20336920.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Isoenzymes; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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29. Han XY, Xiang Y, Guo LN, Sheng K, Wan XR, Huang HF, Pan LY: [Mullerian adenosarcoma of the uterus: A clinicopathologic analysis of 9 cases]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):44-7
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  • [Title] [Mullerian adenosarcoma of the uterus: A clinicopathologic analysis of 9 cases].
  • OBJECTIVE: To investigate the clinicopathologic features, diagnosis, treatment and prognosis of uterine mullerian adenosarcoma.
  • METHODS: The clinicopathological data of 9 cases of uterine mullerian adenosarcoma in PUMC hospital from January 2003 to February 2009 were retrospectively analyzed.
  • RESULTS: There were 6 uterine endometrial adenosarcomas and 3 cervical adenosarcomas.
  • Physical examination showed cervical/vaginal mass, enlarged uterus or pelvic mass.
  • The adenosarcoma was characterized by benign or atypical-appearing neoplastic glands within a sarcomatous stroma.
  • During the follow-up, 2 cases of uterine endometrial adenosarcoma recurred.
  • The other one recurred 2 years after local excision of the tumor in the uterine cavity and she remained healthy since hysterectomy.
  • CONCLUSION: Uterine mullerian adenosarcoma is a rare tumor without specific clinical symptoms and signs.
  • The diagnosis depends on pathomorphologic examination.
  • [MeSH-major] Endometrial Neoplasms / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adenosarcoma / drug therapy. Adenosarcoma / pathology. Adenosarcoma / surgery. Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Etoposide / therapeutic use. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Ifosfamide / therapeutic use. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Uterine Neoplasms / drug therapy. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery. Young Adult

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  • (PMID = 20211067.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; Adenosarcoma of the uterus; ICE protocol 1
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30. Roijer E, de Bruijn HW, Dahlén U, ten Hoor K, Lundin M, Nilsson K, Soderstrom K, Nilsson O: Squamous cell carcinoma antigen isoforms in serum from cervical cancer patients. Tumour Biol; 2006;27(3):142-52
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  • [Title] Squamous cell carcinoma antigen isoforms in serum from cervical cancer patients.
  • SCCA isoforms were determined before therapy and in follow-up samples from patients with cervical cancer and in serum samples from healthy females.
  • Serum samples from patients with benign skin diseases (psoriasis and eczema) were also selected based on elevated SCCA levels.
  • The dominating serological form of SCCA was free SCCA2 both in healthy controls and in patients with cervical cancer.
  • Both SCCA1 and SCCA2 were elevated in serum from cervical cancer patients and followed the clinical course of the disease during therapy monitoring.
  • SCCA2 did not show improved tumor specificity as compared to SCCA1.
  • [MeSH-major] Antigens, Neoplasm / blood. Carcinoma, Squamous Cell / diagnosis. Enzyme-Linked Immunosorbent Assay. Serpins / blood. Uterine Cervical Neoplasms / diagnosis


31. Nowakowski A, Kotarski J: [Clinical manifestations of HPV infections]. Ginekol Pol; 2007 Sep;78(9):709-14
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  • Human papillomavirus (HPV) infections are the causal factors of benign diseases, precancerous lesions and malignancies of various locations.
  • The degree of causality between HPV infections and the development of these disorders varies and reaches 100% in cervical cancer.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / pathology. Papillomavirus Infections / pathology. Uterine Cervical Dysplasia / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Neoplasm Staging. Risk Factors. Women's Health


32. Halloush RA, Akpolat I, Jim Zhai Q, Schwartz MR, Mody DR: Comparison of ProEx C with p16INK4a and Ki-67 immunohistochemical staining of cell blocks prepared from residual liquid-based cervicovaginal material: a pilot study. Cancer; 2008 Dec 25;114(6):474-80
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  • The aim of this study was to evaluate a new marker, ProEx C, on cell blocks and its ability to distinguish dysplastic/malignant lesions from morphologically abnormal but benign cells.
  • On the basis of the cell block diagnosis, 29 cases were negative for intraepithelial lesion or malignancy (NILM), 27 had low-grade squamous intraepithelial lesions (LSIL), 16 had high-grade squamous intraepithelial lesions (HSIL), and 3 had squamous cell carcinomas (SCC).
  • [MeSH-major] Antigens, Neoplasm / analysis. Carcinoma, Squamous Cell / diagnosis. Cell Cycle Proteins / analysis. Cervical Intraepithelial Neoplasia / diagnosis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA Topoisomerases, Type II / analysis. DNA-Binding Proteins / analysis. Ki-67 Antigen / analysis. Nuclear Proteins / analysis. Uterine Cervical Neoplasms / diagnosis. Vaginal Smears / methods

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 19016301.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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33. Fleming NA, Hopkins L, de Nanassy J, Senterman M, Black AY: Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature. J Pediatr Adolesc Gynecol; 2009 Aug;22(4):e45-51
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  • [Title] Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature.
  • Müllerian adenosarcoma is a rare neoplasm usually found in postmenopausal women.
  • It is a biphasic tumor, composed of a benign epithelial component and a malignant stromal component.
  • To date, this neoplasm has been reported in only 16 adolescent girls.
  • At the level of the cervix, there were 3 polypoid gelatinous structures arising from the endocervix and extruding past the exocervix.
  • Hysteroscopic inspection of the uterine cavity did not find any abnormalities.
  • Pathology confirmed a diagnosis of müllerian adenosarcoma originating from the endocervix.
  • Uterine curettings were negative for malignancy.
  • After a thorough evaluation of the available literature, review with the Regional Tumor Board and extensive discussions with the family, a decision was made to perform a radical hysterectomy, bilateral salpingectomy, bilateral pelvic lymph node dissection, upper vaginectomy and preservation of ovaries.
  • CONCLUSION: Müllerian adenosarcoma of the endocervix is a very rare pediatric tumor.
  • Due to the rarity of this tumor in this age group, optimal therapy is uncertain.
  • [MeSH-major] Adenosarcoma / pathology. Uterine Cervical Neoplasms / pathology


34. Melichar B, Solichová D, Freedman RS: Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):240-52
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  • In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders.
  • Elevated levels of neopterin have also been observed in the tumor microenvironment.
  • [MeSH-major] Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / therapy. Immunotherapy / methods. Neopterin / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / analysis. Endometrial Neoplasms / immunology. Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / immunology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Uterine Cervical Neoplasms / immunology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16445639.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 670-65-5 / Neopterin
  • [Number-of-references] 134
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35. Aximu D, Azad A, Ni R, Colgan T, Nanji S: A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. Int J Gynecol Pathol; 2009 Mar;28(2):114-9
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  • [Title] A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics.
  • The histopathologic distinction of cervical adenocarcinoma in situ (AIS) and invasive adenocarcinoma (AC) from some benign endocervical lesions can be challenging.
  • ProEx C immunohistochemical staining was performed on sections from formalin-fixed, paraffin-embedded tissue of 65 cervical tissues including 48 non-neoplastic cervices (normal [n=10], microglandular hyperplasia [n=10], tubal metaplasia [n=11], cervical endometriosis [n=7], reactive endocervix [n=10]) and 17 cervices with glandular malignancy (AIS [n=12] and AC [n=5]).
  • The median and distribution of scores for both prevalence and intensity was compared for AIS versus each of the 5 benign cervical lesions using a Mann-Whitney U test.
  • The median and distribution of prevalence of immunohistochemical staining for AIS was different from all benign mimics, but the intensity of staining for AIS did overlap with some mimics as it was not significantly different from endometriosis, microglandular hyperplasia, and reactive endocervix.
  • ProEx C reagent has potential as an adjunctive testing tool in the histopathologic diagnosis of both AIS and AC, particularly in difficult cases with small biopsies or foci of disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / biosynthesis. Cell Cycle Proteins / biosynthesis. Cervical Intraepithelial Neoplasia / diagnosis. DNA Topoisomerases, Type II / biosynthesis. DNA-Binding Proteins / biosynthesis. Immunohistochemistry / methods. Nuclear Proteins / biosynthesis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Minichromosome Maintenance Complex Component 2. Pilot Projects. Reagent Kits, Diagnostic

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  • (PMID = 19188825.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Reagent Kits, Diagnostic; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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36. Liao SY, Rodgers WH, Kauderer J, Bonfiglio TA, Walker JL, Darcy KM, Carter R, Hatae M, Levine L, Spirtos NM, Stanbridge EJ: Carbonic anhydrase IX and human papillomavirus as diagnostic biomarkers of cervical dysplasia/neoplasia in women with a cytologic diagnosis of atypical glandular cells: a Gynecologic Oncology Group study in United States. Int J Cancer; 2009 Nov 15;125(10):2434-40
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  • [Title] Carbonic anhydrase IX and human papillomavirus as diagnostic biomarkers of cervical dysplasia/neoplasia in women with a cytologic diagnosis of atypical glandular cells: a Gynecologic Oncology Group study in United States.
  • High-risk human papillomavirus (H-HPV) infection is strongly linked to cervical neoplasia, but its role in detecting glandular lesions (GLs) is unclear.
  • In the cervix, carbonic anhydrase IX (CA-IX) is expressed in cervical neoplasia, but rarely in the benign cervix.
  • The diagnostic utility of these biomarkers was evaluated in women with a cytologic diagnosis of atypical glandular cells (AGC).
  • Of 403 patients, 111 (28%) were positive for significant cervical lesions (SCLs) including CIN2, CIN3, adenocarcinoma in situ or invasive carcinoma.
  • The combination of CA-IX with H-HPV testing does not improve the diagnostic accuracy for cervical neoplasia in women with AGC diagnosis over that of H-HPV testing alone.

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  • (PMID = 19670419.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA037517-25; United States / NCI NIH HHS / CA / CA027469-29; United States / NCI NIH HHS / CA / CA 11479; United States / NCI NIH HHS / CA / CA 27469; United States / NCI NIH HHS / CA / U10 CA027469; United States / NCI NIH HHS / CA / U10 CA037517; None / None / / U10 CA037517-25; United States / NCI NIH HHS / CA / CA 37517; United States / NCI NIH HHS / CA / U10 CA027469-29
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA, Viral; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
  • [Other-IDs] NLM/ NIHMS137629; NLM/ PMC2779726
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37. Jun JK, Choi KS, Jung KW, Lee HY, Gapstur SM, Park EC, Yoo KY: Effectiveness of an organized cervical cancer screening program in Korea: results from a cohort study. Int J Cancer; 2009 Jan 1;124(1):188-93
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  • [Title] Effectiveness of an organized cervical cancer screening program in Korea: results from a cohort study.
  • Although the value of cervical cancer screening is widely acknowledged, the effectiveness of an organized cervical cancer screening program in Korea has never been evaluated.
  • We investigated the associations of the frequency of cervical cancer screening with cervical cancer incidence using data from a large prospective cohort study.
  • In this analysis, 253,472 women without a hysterectomy or previous cancer diagnosis were included.
  • Using the Korean Central Cancer Registry, 248 cases of invasive cervical cancer and 346 cases of carcinoma in situ (CIS) of the cervix were identified.
  • Subjects screened 2 or more times showed a 71% (corrected reduction 60%) and a 66% (corrected reduction 53%) reduced risk of invasive cervical cancer and CIS of the cervix, respectively, as compared with unscreened subjects [relative risk (RR) = 0.29; 95% confidence interval (CI) = 0.20-0.45; RR = 0.34; 95% CI = 0.25-0.46, respectively].
  • Women with a normal or benign pap smear had a statistically significantly lower risk of invasive cervical cancer and CIS of cervix compared with those never screened.
  • In age-stratified analyses, there was a significant reduction in cervical cancer incidence among women aged 30 and over who were screened 2 or more times compared with women never screened.
  • The results of this prospective cohort study show that regular screening of cervical cancer reduces invasive cervical cancer incidence and CIS of the cervix among Korean women.
  • [MeSH-major] Mass Screening / methods. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / epidemiology
  • [MeSH-minor] Adult. Body Mass Index. Cohort Studies. Early Detection of Cancer. Female. Humans. Korea. Middle Aged. Neoplasm Invasiveness. Papanicolaou Test. Proportional Hazards Models. Risk. Treatment Outcome. Vaginal Smears


38. Barbanera A, Nina P, Serchi E, Ascanio F: Aggressive recurrence of intra-extradural cervico-thoracic meningothelial meningioma. Acta Neurochir (Wien); 2007 Jan;149(1):83-6; discussion 86
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  • Following subtotal removal, the tumour was histologically classified as meningothelial meningioma and no radiotherapy was recommended.
  • The neuroradiological workup demonstrated that the lesion was stable one year after the operation but, a few months later a tumour recurrence with huge bone destruction was detected.
  • The tumour was totally resected and a circumferential stabilization was performed.
  • The authors discuss the extremely malignant behaviour of a tumour classified as benign.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Cervical Vertebrae. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Invasiveness. Thoracic Vertebrae

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  • (PMID = 17171297.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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39. Vereczkey I, Tóth E, Orosz Z: [Diagnostic problems of ovarian mucinous borderline tumors]. Magy Onkol; 2009 Jun;53(2):127-33
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  • About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors.
  • The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians.
  • These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas.
  • To diagnose the intraepithelial carcinoma, to detect the microinvasion and the expansive invasion in a mucinous borderline tumor, to differentiate from the metastasis of colorectal tumors may be very problematic in the majority of the cases.
  • Eleven cases diagnosed as mucinous borderline ovarian tumor in our institute from 2000 to 2008 were reviewed.
  • Eight out of 11 were intestinal type while three were cervical (mullerian) type.
  • In 5 cases our diagnosis was intraepithelial carcinoma and in 5 cases we found microinvasion.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Biomarkers, Tumor / analysis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. CA-125 Antigen / analysis. Diagnosis, Differential. Female. GPI-Linked Proteins. Homeodomain Proteins / analysis. Humans. Keratin-20 / analysis. Keratin-7 / analysis. Membrane Glycoproteins / analysis. Middle Aged. Neoplasm Invasiveness. Prognosis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 19581178.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CDX2 protein, human; 0 / GPI-Linked Proteins; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / Membrane Glycoproteins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / mesothelin
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40. Kamikabeya TS, Etchebehere RM, Nomelini RS, Murta EF: Gynecological malignant neoplasias diagnosed after hysterectomy performed for leiomyoma in a university hospital. Eur J Gynaecol Oncol; 2010;31(6):651-3
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  • [Title] Gynecological malignant neoplasias diagnosed after hysterectomy performed for leiomyoma in a university hospital.
  • PURPOSE: To analyze the findings of malignant neoplasms after hysterectomy for benign conditions.
  • We analyzed all simple hysterectomies with or without salpingo-oophorectomy for benign conditions (leiomyoma).
  • Of 2,016, 652 (32.3%) had had a previous diagnosis of malignancy and 1,364 (67.7%) had had a clinical diagnosis of benignancy (leiomyoma).
  • From the total of 1,364, three (0.22%) cases of cancer were diagnosed after anatomopathological study of the uterine specimen, two sarcomas and one endometrial cancer.
  • No cases of incidental ovarian or uterine cervical cancer were diagnosed.
  • CONCLUSIONS: Gynecological malignances in surgical specimens of patients submitted to surgery (hysterectomy and/or salpingo-oophorectomy) for benign conditions are rarely found.
  • [MeSH-major] Endometrial Neoplasms / pathology. Hysterectomy / statistics & numerical data. Leiomyoma / surgery. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Brazil / epidemiology. Female. Hospitals, University. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 21319509.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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41. Gong L, Zhang WD, Liu XY, Han XJ, Yao L, Zhu SJ, Lan M, Li YH, Zhang W: Clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma. Diagn Pathol; 2010;5:25
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  • [Title] Clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma.
  • BACKGROUND: Minimal deviation adenocarcinoma (MDA) of the uterine cervix is defined as an extremely well differentiated variant of cervical adenocarcinoma, with well-formed glands that resemble benign glands but show distinct nuclear anaplasia or evidence of stromal invasion.
  • Thus, MDA is difficult to differentiate from other cervical hyperplastic lesions.
  • Thus, our findings indicate that MDA is a true neoplasm but is not associated with high-risk HPV.
  • CONCLUSIONS: Diagnosis of MDA depends mainly on its clinical manifestations, the pathological feature that MDA glands are located deeper than the lower level of normal endocervical glands, and immunostaining.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Cell Differentiation. Chromosomes, Human, X. Receptors, Androgen / genetics. Uterine Cervical Neoplasms / genetics. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Case-Control Studies. Cell Proliferation. DNA, Viral / analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization. Mosaicism. Neoplasm Invasiveness. Papillomaviridae / genetics. Polymerase Chain Reaction. Polymorphism, Genetic. Predictive Value of Tests. Stromal Cells / pathology


42. Rezvani M, Shaaban A: Imaging of cervical pathology. Clin Obstet Gynecol; 2009 Mar;52(1):94-111
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  • [Title] Imaging of cervical pathology.
  • A variety of benign and malignant entities affect the uterine cervix.
  • Cross-sectional and functional imaging can improve the accuracy of traditional clinical cervical cancer staging.
  • The imaging appearance of benign cervical pathology is reviewed with ultrasonography as the first-line imaging modality and magnetic resonance imaging for problem solving in difficult cases.
  • [MeSH-major] Cervix Uteri / pathology. Magnetic Resonance Imaging / methods. Ultrasonography / methods. Uterine Cervical Diseases / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Neoplasm Staging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods


43. Yi KW, Song SH, Kim KA, Jung WY, Lee JK, Hur JY: Giant endocervical polyp mimicking cervical malignancy: primary excision and hysteroscopic resection. J Minim Invasive Gynecol; 2009 Jul-Aug;16(4):498-500
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  • [Title] Giant endocervical polyp mimicking cervical malignancy: primary excision and hysteroscopic resection.
  • Giant cervical polyps are characterized by an unusually large size and appear clinically as malignant.
  • Pelvic magnetic resonance imaging revealed a 12.6 x 8-cm solid tumor with internal papillary growth within the entire vaginal cavity.
  • The tumor base was suspected to have originated from the endocervix by a connecting stalk.
  • Primary excision of the tumor was performed via the vagina, and the remnant tissue was completely removed at hysteroscopic resection.
  • The final histopathologic findings confirmed a benign giant cervical polyp.
  • [MeSH-major] Polyps / pathology. Uterine Cervical Diseases / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm / blood. Female. Humans. Hysteroscopy. Serpins / blood

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  • (PMID = 19573830.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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44. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7
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  • All patients were surgically managed and their tumour specimen was sent for histopathology.
  • Classification of individual tumour was based on 1991 World Health Organization Classification.
  • RESULTS: Out of 204 cases, 152 (74.5%) were benign and 52 (25.5%) were malignant.
  • Benign tumours were more common in females whereas malignant tumours were common in males.
  • The mean age of patients was 34 years and 42 years for benign and malignant tumours respectively.
  • Pleomorphic adenoma was most common benign tumor (83.5%), followed by Warthins tumour.
  • The most common malignant tumour was mucoepidermoid carcinoma (60%), followed by adenoid cystic carcinoma.
  • Superficial lobe of parotid gland was the commonest site, 120 benign and all 52 malignant tumours arising from it while 32 benign tumours originated from deep lobe.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Morbidity / trends. Neoplasm Staging / methods. Pakistan / epidemiology. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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45. Tsai HT, Tsai YM, Yang SF, Wu KY, Chuang HY, Wu TN, Ho CK, Lin CC, Kuo YS, Wu MT: Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm--a community-based case-control study. Gynecol Oncol; 2007 Apr;105(1):181-8
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  • [Title] Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm--a community-based case-control study.
  • BACKGROUND: Both active cigarette smoking and human papillomavirus (HPV) infection are known risk factors for cervical intraepithelial neoplasm (CIN).
  • A total of 171 subjects with either their first case of inflammation (benign epithelial lesion) or > or = CIN1 by biopsy confirmation were assigned to a case group; 513 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Smoking / adverse effects. Tobacco Smoke Pollution / adverse effects. Uterine Cervical Neoplasms / epidemiology


46. Pino Rivero V, Trinidad Ruiz G, Pardo Romero G, González Palomino A, Pantoja Hernández CG, Marqués Rebollo L, Blasco Heulva A: [Cervical giant lipoma. Clinical report of a case and differential diagnosis]. An Otorrinolaringol Ibero Am; 2005;32(4):345-51
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  • [Title] [Cervical giant lipoma. Clinical report of a case and differential diagnosis].
  • [Transliterated title] Lipoma gigante cervical. Presentación clínica de un caso y diagnóstico diferencial.
  • Lipomas represent one of the most common benign tumours in any location.
  • However, the giant variants are relatively uncommon and cause diagnostic problems with other neoplasm benign and malign.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Lipoma / radiography
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 16156364.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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47. Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L: Cervical vagal schwannoma. A case report. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):33-5
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  • [Title] Cervical vagal schwannoma. A case report.
  • Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm.
  • These tumours, in fact, are almost always benign and a conservative surgical approach is emphasized by most of the Authors.
  • A case of a cervical vagal schwannoma, in a 33-year old male with a previous medical history of malignant lymphoma, is described.
  • The clinical features, diagnosis, management and pathological findings of cervical vagal schwannoma are discussed.
  • [MeSH-major] Cranial Nerve Neoplasms. Neurilemmoma. Vagus Nerve Diseases

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  • [Cites] J Laryngol Otol. 2000 Feb;114(2):119-24 [10748827.001]
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  • (PMID = 19609380.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689565
  • [Keywords] NOTNLM ; Benign tumours / Magnetic Resonance imaging / Schwannoma / Vagus nerve
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48. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • A massive neoplasm located in intraspinal cervicothoracic junction and the spinal cord compressed severely was shown in radiographs, MRI, and CT.
  • The neoplasm was removed totally with instrumentation performed in surgical intervention.
  • Recurrence of the tumor was not seen at the final follow-up.
  • [MeSH-major] Cervical Vertebrae. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Spinal Canal / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Female. Humans. Magnetic Resonance Imaging. Pain / etiology. Spinal Cord Compression / diagnosis. Spinal Cord Compression / etiology. Thoracic Vertebrae / radiography. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Hammes LS, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Syrjänen KJ, Cunha-Filho JS: Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Gynecol Oncol; 2008 Sep;110(3):445-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease.
  • OBJECTIVES: To describe the expression of vascular endothelial growth factor (VEGF), proto-oncogene macrophage colony-stimulating factor receptor (c-fms) and cyclooxygenase-2 (COX-2) in cervical carcinogenesis and to analyze the correlation of VEGF with c-fms and COX-2 expression.
  • METHODS: In this study, 26 cases of benign cervix, 28 low-grade cervical intraepithelial neoplasia (CIN; CIN 1), 30 high-grade CIN (CIN 2/3) and 28 squamous cervical carcinomas (SCC) were examined by immunohistochemistry (IHC) and analysis was performed separately for epithelium and stroma.
  • RESULTS: Positive epithelial expressions in normal cervix, low-grade CIN, high-grade CIN and SCC were, respectively: VEGF - 11.5%, 39.3%, 53.3% and 75% (P<0.001); c-fms - 0%, 10.7%, 40% and 67.9% (P<0.001); COX-2 - 7.7%, 39.3%, 80% and 100% (P<0.001).
  • CONCLUSIONS: On the basis of our findings, these factors may participate in the development and progression of CIN lesions, with possible interaction of c-fms and COX-2 on VEGF expression, and may be potential molecular targets for studies of cervical cancer prevention and treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Cervical Intraepithelial Neoplasia / metabolism. Cyclooxygenase 2 / biosynthesis. Receptor, Macrophage Colony-Stimulating Factor / biosynthesis. Uterine Cervical Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Neoplasm Invasiveness. Neoplasm Staging. Neovascularization, Pathologic / genetics. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Up-Regulation


50. Wadasadawala T, Trivedi S, Gupta T, Epari S, Jalali R: The diagnostic dilemma of primary central nervous system melanoma. J Clin Neurosci; 2010 Aug;17(8):1014-1017
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  • Melanomas are malignant neoplasms of melanocytes developing predominantly in the skin, but occasionally arising from eyes, mucous membranes, and the central nervous system (CNS).
  • The CNS can be affected by a spectrum of melanocytic lesions ranging from diffuse neurocutaneous melanosis, to a focal and benign neoplasm (melanocytoma), and to an overtly malignant tumor (melanoma).
  • Primary melanocytic lesions involving the CNS are typically concentrated in the perimedullary and high cervical region.
  • Primary CNS melanoma cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone: its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebellopontine Angle / pathology. Melanoma / pathology. Parietal Lobe / pathology

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  • (PMID = 20627582.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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51. Agur W, Hassan M, Laban M, Morsi H, Abou-Senna I: The relationship between bcl-2 oncogene expression and clinicopathological criteria in various stages of cervical neoplasia in Egyptian women. Eur J Gynaecol Oncol; 2010;31(5):536-8
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  • [Title] The relationship between bcl-2 oncogene expression and clinicopathological criteria in various stages of cervical neoplasia in Egyptian women.
  • PURPOSE: To assess the degree of bcl-2 expression in the various stages of cervical neoplasia in a sample population of Egyptian women and relate the findings to clinicopathological criteria of invasive cervical cancer.
  • METHODS: Bcl-2 protein expression was assessed by immuno-histochemistry in 40 patients with cervical neoplasia (intraepithelial and invasive) in comparison to 20 patients with benign changes.
  • Patients with invasive disease were followed up 2 years later and the outcome was correlated to the bcl-2 status at the time of diagnosis.
  • RESULTS: Bcl-2 expression increased from 20% in normal cervical tissue to 42.9% in cervical intraepithelial neoplasia grade II then dropped to 33% in invasive disease.
  • CONCLUSION: Bcl-2 expression is reduced along the spectrum from benign towards invasive disease of the cervix.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / metabolism. Cervical Intraepithelial Neoplasia / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Case-Control Studies. Cross-Sectional Studies. Egypt. Female. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 21061795.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
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52. Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ: Cervical lymph nodes. Eur J Radiol; 2008 Jun;66(3):493-500
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  • [Title] Cervical lymph nodes.
  • A spherical lymph node larger than 10mm is an indicator for a malignant node, whereas an oval shape and/or a fatty hilus are more benign signs.
  • This is causing a signal decrease on T2-weighted MR images in benign lymph nodes after administration of USPIO's, whereas malignant lymph nodes do not show a significant signal decrease.
  • [MeSH-major] Diagnostic Imaging. Head and Neck Neoplasms / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Dextrans. Ferrosoferric Oxide. Humans. Iron. Lymph Nodes / pathology. Magnetite Nanoparticles. Neoplasm Invasiveness / diagnosis. Neoplasm Staging. Oxides. Prognosis

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  • (PMID = 18337039.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Number-of-references] 45
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53. Fadare O, Yi X, Liang SX, Ma Y, Zheng W: Variations of mitotic index in normal and dysplastic squamous epithelium of the uterine cervix as a function of endometrial maturation. Mod Pathol; 2007 Sep;20(9):1000-8
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  • [Title] Variations of mitotic index in normal and dysplastic squamous epithelium of the uterine cervix as a function of endometrial maturation.
  • Cervical intraepithelial neoplasia is a premalignant (dysplastic) lesion that is characterized by abnormal cellular proliferation, maturation and nuclear atypia.
  • In this study, we evaluated the total mitotic indices of the cervical epithelia in hysterectomy specimens from patients with and without dysplastic lesions and investigated a possible relationship between mitotic index and hormonal status, using the endometrial maturation phase as a surrogate indicator of the latter.
  • Two hundred seventy-four cervices from hysterectomy specimens (135 cases without dysplasia, 33, 35 and 71 cases with grades 1, 2 and 3 cervical intraepithelial neoplasia, respectively) were analyzed.
  • A cervical mitotic index (total mitotic figures/10 high-power fields in the most proliferative area) was determined for each case.
  • For all three dysplasia grades, cases in the proliferative endometrium group always had a higher average mitotic index than those in the secretory and atrophic endometrium groups; this observation also held true for the benign cases.
  • Notably, the average mitotic index for our cervical intraepithelial neoplasia 1 cases with late proliferative endometrium was higher than our cervical intraepithelial neoplasia 2 cases with secretory and atrophic endometrium.
  • It is concluded that hormonal status, as reflected in endometrial maturation, can significantly affect the mitotic index of dysplastic squamous epithelium of the uterine cervix.
  • Our findings confirm that the pathologic grading of dysplasia, especially in equivocal cases such as in metaplastic squamous epithelium, should not be solely dependent on the finding mitoses in the cervical squamous epithelium.
  • [MeSH-major] Cell Proliferation. Cervical Intraepithelial Neoplasia / diagnosis. Cervix Uteri / pathology. Endometrium / pathology. Epithelial Cells / pathology. Menstrual Cycle. Mitotic Index. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Metaplasia. Middle Aged. Neoplasm Staging. Retrospective Studies


54. Kumar R, Giri PJ: Pediatric extradural spinal tumors. Pediatr Neurosurg; 2008;44(3):181-9
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  • We have reviewed 16 children with extradural spinal tumors, both benign and malignant, treated from 1998 to 2006 in Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • The duration of symptoms was 2-18 months, relatively longer in benign (mean 9.5 months) than malignant (mean 4.2 months) tumors.
  • [MeSH-major] Epidural Neoplasms / pathology. Epidural Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Male. Neoplasm Recurrence, Local. Retrospective Studies. Sacrum / pathology. Sacrum / surgery

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  • (PMID = 18334840.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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55. Tinoco RC, Tinoco AC, El-Kadre LJ, Rios RA, Sueth DM, Pena FM: [Laparoscopic transhiatal esophagectomy: outcomes]. Arq Gastroenterol; 2007 Apr-Jun;44(2):141-4
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  • BACKGROUND: The laparoscopic transhiatal esophagectomy for benign or malignant disease is a complex operation associated with a high rate of morbidity and mortality.
  • In the last decade this procedure gained popularity and acceptance for treatment of the esophagus cancer and other benign diseases.
  • Sixty-four with malignant neoplasm of esophagus.
  • The abdominal part of the operation was totally laparoscopic and the cervical one was made the conventional way.
  • The incidence of cervical fistula was 14.06%.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17962860.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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56. Happle C, Wetzke M, Hermann EJ, Krauss JK, Hartmann H, Lücke T: ['Cases against KiSS': a diagnostic algorithm for children with torticollis]. Klin Padiatr; 2009 Dec;221(7):430-5
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  • He assumed a functional abnormality of the suboccipital-high cervical spine, resulting in positional preference of the infant;s head.
  • Patients are advised to undergo manual therapy, with pressure applied locally in order to readjust the cervical spine.
  • In both cases, symptoms caused by the tumour were interpreted as "KiSS-syndrome", and appropriate diagnostics and therapy were delayed for months.
  • Whereas most cases are benign, there is a long list of serious differential diagnoses for torticollis in infants.
  • [MeSH-major] Algorithms. Astrocytoma / diagnosis. Cerebellar Neoplasms / diagnosis. Cervical Vertebrae. Ganglioglioma / diagnosis. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Spinal Diseases / diagnosis. Torticollis / etiology
  • [MeSH-minor] Child, Preschool. Diagnostic Errors. Gait Disorders, Neurologic / etiology. Humans. Infant. Male. Microsurgery. Neoplasm, Residual / diagnosis. Neurologic Examination. Postoperative Complications / diagnosis. Reoperation. Syndrome

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart New York.
  • (PMID = 20013566.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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57. Ungureanu C, Teleman S, Socolov D, Anton G, Mihailovici MS: [Evaluation of p16INK4a and Ki-67 proteins expression in cervical intraepithelial neoplasia and their correlation with HPV-HR infection]. Rev Med Chir Soc Med Nat Iasi; 2010 Jul-Sep;114(3):823-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluation of p16INK4a and Ki-67 proteins expression in cervical intraepithelial neoplasia and their correlation with HPV-HR infection].
  • OBJECTIVE: The aim of our study was to evaluate the expression of p16INK4A and Ki-67 in cervical intraepithelial neoplasia (CIN) and to correlate the high-risk human papillomavirus (HPV) infection with these two biomarkers.
  • RESULTS: 7 of our cases were benign (11.66%); 18 cases presented CIN1 (30%), 14 cases CIN2 (23.33%), 16 cases CIN3 (26.66%) and 5 cases invasive squamous cell carcinoma (8.33%).
  • Therefore, in the diagnosis of CIN and high-risk HPV infection, p16INK4A can be a useful biomarker.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Cervical Intraepithelial Neoplasia / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomavirus Infections / metabolism. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 21243810.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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58. Comunoğlu N, Comunoğlu C, Başsüllü N, Somunkiran A, Calay Z: Müllerian adenosarcoma with sarcomatous overgrowth of the cervix: unusual large polypoid mass. Ups J Med Sci; 2007;112(1):67-72
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  • [Title] Müllerian adenosarcoma with sarcomatous overgrowth of the cervix: unusual large polypoid mass.
  • Müllerian adenosarcoma (MS) is a rare neoplasm of uterine cervix composed of benign epithelial and malignant stromal components.
  • In this report we present a MASO case, derived from uterine cervix of a 60 year-old-female patient presenting as a cervical polypoid mass, to our knowledge the second case of the English literature.
  • In spite of sarcomatous overgrowth, high mitotic activity and huge tumor size of 12,5 cms, it displayed no myometrial invasion, vascular invasion and heterologous elements.
  • The difficulties in diagnosis and treatment of this entity will be evaluated in this report.
  • [MeSH-major] Adenosarcoma / diagnosis. Mixed Tumor, Mullerian / diagnosis. Uterine Cervical Neoplasms / diagnosis


59. D'Cunha J, Herndon JE 2nd, Herzan DL, Patterson GA, Kohman LJ, Harpole DH, Kernstine KH, Kern JA, Green MR, Maddaus MA, Kratzke RA, Cancer and Leukemia Group B: Poor correspondence between clinical and pathologic staging in stage 1 non-small cell lung cancer: results from CALGB 9761, a prospective trial. Lung Cancer; 2005 May;48(2):241-6
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  • METHODS: Five hundred and two patients with suspected or biopsy-proven NSCLC classified as clinical stage 1 (T1-2, N0) by computed tomography (CT) scan or cervical mediastinoscopy were prospectively enrolled in CALGB 9761.
  • Of the patients undergoing resection for clinical stage 1 NSCLC, 65 patients did not have NSCLC (44 had benign disease and 21 had malignancies other than NSCLC) and two additional patients had dual synchronous primary NSCLC tumors and were not eligible for the study.
  • Overall, only 61.7% (302 of 489) of patients with suspected stage 1 NSCLC disease retained that stage and diagnosis after complete surgical staging, while 38.3% had an inaccurate pre-operative clinical stage or diagnosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Neoplasm Staging / methods. Neoplasm Staging / standards

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  • (PMID = 15829324.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA04326; United States / NCI NIH HHS / CA / CA12046; United States / NCI NIH HHS / CA / CA16450; United States / NCI NIH HHS / CA / CA21060; United States / NCI NIH HHS / CA / CA31946; United States / NCI NIH HHS / CA / CA31983; United States / NCI NIH HHS / CA / CA32291; United States / NCI NIH HHS / CA / CA47577; United States / NCI NIH HHS / CA / CA47642; United States / NCI NIH HHS / CA / CA77440
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Ireland
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60. Lowe MP, Chamberlain DH, Kamelle SA, Johnson PR, Tillmanns TD: A multi-institutional experience with robotic-assisted radical hysterectomy for early stage cervical cancer. Gynecol Oncol; 2009 May;113(2):191-4
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  • [Title] A multi-institutional experience with robotic-assisted radical hysterectomy for early stage cervical cancer.
  • OBJECTIVE: The purpose of the study is to report a multi-institutional experience with robotic-assisted radical hysterectomy to treat patients with early stage cervical cancer with respect to perioperative outcomes.
  • METHODS: A multi-institutional robotic surgical consortium consisting of five board-certified gynecologist oncologist in distinct geographical regions of the United States was created to evaluate the utility of robotics for gynecologic surgery (benign and malignant).
  • Between April 2003 and August 2008, a total of 835 patients underwent robotic surgery for benign gynecologic disorders and/or gynecologic malignancies by a surgeon in the consortium.
  • This database was queried for all patients who underwent a robotic-assisted type II or III radical hysterectomy for Stage IA1 (+vsi)-IB2 cervical carcinoma.
  • RESULTS: From a database of 835 patients who underwent robotic surgery by a gynecologic oncologist, a total of 42 patients who underwent a robotic-assisted type II (n=10) or type III (n=32) radical hysterectomy for early stage cervical cancer were identified.
  • There was a single patient with Stage IA1 cervical cancer with vascular space invasion who underwent a type II radical hysterectomy.
  • [MeSH-major] Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Hysterectomy. Laparoscopy. Neoplasm Staging. Retrospective Studies. Robotics. Treatment Outcome


61. Schmidt D, Szikszai A, Linke R, Bautz W, Kuwert T: Impact of 131I SPECT/spiral CT on nodal staging of differentiated thyroid carcinoma at the first radioablation. J Nucl Med; 2009 Jan;50(1):18-23
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  • The planar scans and the SPECT/CT images were evaluated for cervical tracer uptake independently of each other and of the clinical findings.
  • RESULTS: SPECT/CT led to a revision of the original diagnosis in 28 of 143 cervical foci of radioiodine uptake seen on planar imaging.
  • In particular, SPECT/CT reclassified as benign 6 of 11 lesions considered to be lymph node metastases and 11 of 15 lesions considered to be indeterminate.
  • [MeSH-major] Ablation Techniques. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Iodine Radioisotopes / metabolism. Lymph Nodes / pathology. Lymph Nodes / radiography. Lymph Nodes / radionuclide imaging. Lymph Nodes / surgery. Male. Middle Aged. Neoplasm Staging. Tomography, Emission-Computed, Single-Photon. Tomography, Spiral Computed. Whole Body Imaging

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  • [CommentIn] J Nucl Med. 2009 Aug;50(8):1386; author reply 1386 [19617337.001]
  • (PMID = 19091884.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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62. George B, Archilli M, Cornelius JF: Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases. Acta Neurochir (Wien); 2006 Jul;148(7):741-9; discussion 749
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  • [Title] Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases.
  • BACKGROUND: Bone tumors located at the cranio-cervical junction (CCJ)are rare.
  • METHODS: Forty-one patients presenting a bone tumor (26 benign and 15 malignant tumors), excluding chordomas, located at the CCJ (including lower third of the clivus, C1 and C2) were observed over 20 years from 1981 to 2001.
  • Vertebral angiography was rarely performed (N=9) and mostly when the diagnosis was doubtful.
  • In some cases the diagnosis was clear but in others, imaging studies showed destructive lesions suggesting a malignancy, which sometimes required a biopsy (N=4).
  • No recurrence in the group of benign tumors was seen during an average follow-up of 6 years (from 2 to 11 years).
  • Confusion between benign and malignant tumor or pseudo tumors must be avoided, sometimes requiring a biopsy.
  • [MeSH-major] Axis, Cervical Vertebra / surgery. Bone Neoplasms / surgery. Cervical Atlas / surgery. Neurosurgical Procedures / methods. Occipital Bone / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebral Angiography. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck Pain / etiology. Neck Pain / physiopathology. Neck Pain / surgery. Neoplasm Metastasis / pathology. Neoplasm Metastasis / radiography. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Spinal Fusion. Tomography, X-Ray Computed. Treatment Outcome. Vertebral Artery / anatomy & histology. Vertebral Artery / pathology. Vertebral Artery / surgery

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  • (PMID = 16708168.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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63. Cremer ML, Alonzo TA, Alspach AE, Shulman IA, Cernosek S, Tsai S, Kalichanda N, Felix JC: Diagnostic reproducibility of cervical intraepithelial neoplasia 3 and atrophy in menopausal women on hematoxylin and eosin, Ki-67, and p16 stained slides. J Low Genit Tract Dis; 2010 Apr;14(2):108-12
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  • [Title] Diagnostic reproducibility of cervical intraepithelial neoplasia 3 and atrophy in menopausal women on hematoxylin and eosin, Ki-67, and p16 stained slides.
  • OBJECTIVE: To establish diagnostic accuracy and reproducibility of a diagnosis of cervical intraepithelial neoplasia 3 (CIN 3) in menopausal women on routinely stained hematoxylin and eosin (H&E) slides and compare it to slides processed for p16 and Ki-67.
  • MATERIALS AND METHODS: Confirmed cases of CIN 3 and benign atrophic changes were reviewed independently by 4 pathologists.
  • CONCLUSIONS: Routine histopathologic diagnosis of CIN 3 in menopausal women is highly accurate and reproducible.
  • Both H&E and Ki-67 are useful immunohistochemical stains in helping differentiate atrophy from high-grade cervical intraepithelial lesions in postmenopausal cervical biopsies.
  • [MeSH-major] Atrophy / diagnosis. Cervical Intraepithelial Neoplasia / diagnosis. Pathology / methods
  • [MeSH-minor] Aged. Female. Histocytochemistry / methods. Humans. Immunohistochemistry / methods. Ki-67 Antigen / analysis. Menopause. Middle Aged. Neoplasm Proteins / analysis. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20354418.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human
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64. Scott ME, Ma Y, Kuzmich L, Moscicki AB: Diminished IFN-gamma and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3. Int J Cancer; 2009 Mar 15;124(6):1379-83
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  • [Title] Diminished IFN-gamma and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3.
  • Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN).
  • Using quantitative RT-PCR, we measured, in cross-sectional design, the cervical mRNA expression of IFN-gamma, IL-10, and IL-12, as well as the Treg transcription factor Forkhead box P3 (Foxp3), in a cohort of young women representing CIN 1, 2, and 3, as well as benign histology.
  • Higher levels of IFN-gamma and IL-10 were significantly (p <or= 0.05) associated with decreased odds of having high-grade cervical disease (CIN 2 or 3) in multivariate logistic regression models.
  • In a multivariate model including cervical infection with HPV16 and/or another high-risk HPV type, Foxp3 remained higher in the CIN 2/3 group, but the difference was notably less significant (p = 0.05).
  • These findings support a model in which diminished cellular immunity in the cervical mucosa and mucosal enrichment of Treg cells both contribute to the development of high-grade lesions.

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  • (PMID = 19089920.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA087905; United States / NCI NIH HHS / CA / CA051323-15; United States / NCI NIH HHS / CA / R01 CA087905-05S1; United States / NCI NIH HHS / CA / 2 R01 CA87905; United States / NCI NIH HHS / CA / R01 CA051323-15; United States / NCI NIH HHS / CA / R01 CA051323; United States / NCI NIH HHS / CA / R37 CA051323-19; United States / NCI NIH HHS / CA / CA051323-19; United States / NCI NIH HHS / CA / CA087905-05S1; United States / NCI NIH HHS / CA / 2 R37 CA051323; United States / NCI NIH HHS / CA / 2 R01 CA51323; United States / NCI NIH HHS / CA / R37 CA051323
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 130068-27-8 / Interleukin-10; 63231-63-0 / RNA; 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ NIHMS98768; NLM/ PMC2696072
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66. Korach J, Machtinger R, Perri T, Vicus D, Segal J, Fridman E, Ben-Baruch G: Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge. Acta Obstet Gynecol Scand; 2009;88(3):355-8
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  • [Title] Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge.
  • Villoglandular papillary adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma.
  • The aim of our study was to evaluate the reliability of histological assessment for pre-treatment diagnosis of VGA.
  • Median age at diagnosis was 38.8 years (range 27-65).
  • Of these, only two had been correctly diagnosed preoperatively, while in three, the initial biopsies were benign or pre-malignant.
  • In four patients, the biopsy results had been interpreted as an invasive malignant tumor necessitating hysterectomy.
  • The final histological report on the remaining three patients was invasive cervical adenocarcinoma.
  • We conclude that pre-treatment diagnosis should not be based solely on a simple punch biopsy because of its low rate of diagnostic accuracy.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Cervix Uteri / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Diagnostic Errors. Female. Humans. Middle Aged. Neoplasm Staging


67. Zhi KQ, Ren WH, Zhang L, Wen YM, Zhang YC: [Diagnosis and surgical approach of parapharyngeal space neoplasms]. Shanghai Kou Qiang Yi Xue; 2007 Oct;16(5):547-50
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  • [Title] [Diagnosis and surgical approach of parapharyngeal space neoplasms].
  • PURPOSE: The aim of this study is to investigate the diagnosis and reasonable surgical approach for parapharyngeal space neoplasms.
  • METHODS: A retrospective study was carried out from the data of 24 patients, who suffered from paralaryngeal space neoplasms and underwent surgical treatment from 1998 to 2006.
  • Most patients visited the doctor with cervical or submandibular masses and some of them with disorders of swallowing or speech.
  • 87.5% of the neoplasms were benign and 12.5% were malignant.
  • CT or MRI provided useful information such as their sizes, shapes, extents and the relationship between the neoplasm and surrounding tissues.
  • The trans-cervical approach was used in 10 cases, the trans-parotid approach in 10 cases, the trans-mandible approach in 4 cases.
  • CONCLUSIONS: CT and/or MRI are essentially useful tools for diagnosis and presurgical planning.
  • Based on the trans-cervical approach, according to the size, origination and nature of the neoplasms, choose of the trans-parotid or the trans- mandibular approach for surgical treatment is reasonable.
  • [MeSH-major] Pharyngeal Neoplasms / surgery

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  • (PMID = 18004491.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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68. Dangore-Khasbage S, Degwekar SS, Bhowate RR, Banode PJ, Bhake A, Choudhary MS, Lohe VK: Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Aug;108(2):255-63
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  • [Title] Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer.
  • OBJECTIVE: The aim was to study the utility of color Doppler ultrasound (CDUS) in diagnosis of cervical lymphadenopathy in oral cancer patients.
  • STUDY DESIGN: In a prospective study, 70 cervical lymph nodes in 30 known primary oral cancer patients were evaluated with CDUS during a period of 8 months.
  • The intranodal perfusion sites and vascular resistance were the key CDUS features used to differentiate between reactive and metastatic cervical lymph nodes.
  • The results of preoperative clinical palpation of cervical lymph nodes and CDUS evaluation were compared with histopathologic outcome.
  • RESULTS: Clinical evaluation suspected 61 cervical lymph nodes to be malignant.
  • According to the CDUS, out of 70 nodes, 49 lymph nodes showed features of benign lymphadenopathy and 21 lymph nodes showed features of malignant lymphadenopathy, whereas histopathologic evaluations were in favor of reactive for 57 (81.42%) and for malignant lymphadenopathy in 13 (18.57%).
  • [MeSH-major] Lymph Nodes / ultrasonography. Lymphatic Metastasis / ultrasonography. Mouth Neoplasms / pathology. Ultrasonography, Doppler, Color
  • [MeSH-minor] Female. Humans. Lymphatic Diseases / pathology. Lymphatic Diseases / ultrasonography. Male. Neck. Neoplasm Staging / methods. Prospective Studies. Regional Blood Flow. Sensitivity and Specificity. Sentinel Lymph Node Biopsy. Statistics, Nonparametric

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  • (PMID = 19272807.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Sima N, Cai L, Zhu Y, Wang W, Wang S, Ma D: Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. J Huazhong Univ Sci Technolog Med Sci; 2007 Aug;27(4):451-3
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  • [Title] Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma.
  • Telomerase activity was examined in invasive cervical carcinoma to assess whether it is activated during cervical malignant transformation and to look for its possible association with human papillomavirus (HPV) infection.
  • Histologically confirmed invasive cervical carcinomas and benign cervices were assayed for telomerase activity by using a modified telomere repeat amplification protocol (TRAP).
  • Telomerase activity was detected in 40 of 45 (88.9%) invasive cervical carcinomas and 2 (all chronic cervicitis) of 50 (4%) benign cervical lesions.
  • HPV was detected in 36 (24 HPV-16 and 4 HPV-18 cases) of 45 (80%) invasive cervical carcinomas and 20 (11 HPV-16 and 1 HPV-18 cases) of 50 (40%) benign cervical changes.
  • [MeSH-major] Neoplasm Invasiveness. Papillomavirus Infections / enzymology. Telomerase / metabolism. Uterine Cervical Neoplasms / enzymology. Uterine Cervical Neoplasms / virology

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  • (PMID = 17828509.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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70. Bala A, Robbins P, Knuckey N, Wong G, Lee G: Spinal chondromyxoid fibroma of C2. J Clin Neurosci; 2006 Jan;13(1):140-6
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  • Chondromyxoid fibroma of bone (CMF) is a rare benign primary bone neoplasm accounting for less than 0.5% of all primary bone neoplasms.
  • The spine is an uncommon site for this tumour, with forty-two cases reported in the modern English literature.
  • This is the second reported case of this rare tumour in this location.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Fibroma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae / pathology. Child. Female. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray / methods

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  • (PMID = 16410218.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 39
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71. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • Cervical lymph nodes were evaluated with ultrasonography preoperatively to exclude metastasis and no pathologic lymph nodes were noted.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Dunham CP, Curry B, Hamilton M: Malignant transformation of an intraaxial-supratentorial neurenteric cyst - case report and review of the literature. Clin Neuropathol; 2009 Nov-Dec;28(6):460-6
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  • Neurenteric cysts are "rare benign mass forming developmental abnormalities" that usually affect young adults.
  • Anatomically, neurenteric cysts most frequently arise in an intradural-extraaxial location anterior to the cervical-thoracic spinal cord.
  • Areas of direct transition between typical benign neurenteric cyst epithelia and malignant epithelia (i.e., carcinoma in situ), highlighted by an abrupt change in the Ki-67 proliferative index, were identified, and supported the primary nature of this brain neoplasm.
  • [MeSH-major] Cystadenocarcinoma, Papillary / diagnosis. Cystadenocarcinoma, Papillary / etiology. Neural Tube Defects / complications. Supratentorial Neoplasms / diagnosis. Supratentorial Neoplasms / etiology

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  • (PMID = 19919821.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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73. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Field JB, Benoit MF, Dinh TA, Diaz-Arrastia C: Computer-enhanced robotic surgery in gynecologic oncology. Surg Endosc; 2007 Feb;21(2):244-6
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  • Of the 20 patients with gynecologic malignancies, 14 had cervical cancer.
  • A total of 21 patients had benign indications for surgery.
  • [MeSH-major] Genital Neoplasms, Female / surgery. Gynecologic Surgical Procedures / instrumentation. Robotics / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Incidence. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Neoplasm Staging. Postoperative Complications / epidemiology. Retrospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 17186433.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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75. Attene F, Scognamillo F, Xidas A, Serventi F, Trignano M: [The role of cervical mediastinoscopy and video assisted thoracoscopy in the diagnosis and staging of thoraco-mediastinal neoplastic diseases]. Ann Ital Chir; 2009 Jan-Feb;80(1):17-24
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  • [Title] [The role of cervical mediastinoscopy and video assisted thoracoscopy in the diagnosis and staging of thoraco-mediastinal neoplastic diseases].
  • [Transliterated title] Ruolo della mediastinoscopia e della video toracoscopia per la diagnosi e la stadiazione delle patologie neoplastiche toraco-mediastiniche.
  • INTRODUCTION: In this work we evaluate the role of mediastinoscopy and video-assisted thoracoscopy in the diagnosis and staging of coin lesion of the lung and of mediastinal masses.
  • MATERIALS AND METHODS: 72 patients, 55 males and 17 females, affected by lung coin lesion without any previous histological diagnosis have been admitted to our Institution from 1997 to 2007.
  • In just one case mediastinoscopy failed and video assisted thoracoscopy was performed, which permitted to obtain diagnosis.
  • Video assisted thoracoscopy was able to lead to diagnosis in 98.1% of cases, as we observed only one failure.
  • In this single case we converted the thoracoscopic approach to open, but although the conversion it was not possible to make diagnosis.
  • DISCUSSION: In these ten years, thanks to adequate indication for mediastinoscopy and video assisted thoracoscopy, the use of thoracotomy for diagnosis and staging of pulmonary neoplastic diseases has been reduced: thus we avoided 80% of unnecessary thoracotomies in patients affected by not resectable lung cancer, metastases (treated by atypical thoracoscopic resection) or benign diseases.
  • [MeSH-major] Lung Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Mediastinoscopy. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Lung Diseases / diagnosis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Prognosis. Retrospective Studies. Solitary Pulmonary Nodule / diagnosis. Treatment Outcome

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  • (PMID = 19537118.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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76. Na JH, Kim HS, Eoh W, Kim JH, Kim JS, Kim ES: Spinal cord hemangioblastoma : diagnosis and clinical outcome after surgical treatment. J Korean Neurosurg Soc; 2007 Dec;42(6):436-40
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  • [Title] Spinal cord hemangioblastoma : diagnosis and clinical outcome after surgical treatment.
  • OBJECTIVE: Spinal cord hemangioblastoma is an uncommon vascular neoplasm with a benign nature and is associated with von Hippel-Lindau (VHL) disease in 20-30% of patients.
  • Magnetic resonance imaging (MRI) of the complete neuraxis was done in all cases and VHL mutation analysis was performed in three cases for a definite diagnosis.
  • RESULTS: Six patients had intramedullary tumor, and the remaining patients had intradural extramedullary lesions.
  • Tumors were located in the cervical cord in five cases and in the thoracic cord in four cases.

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  • (PMID = 19096585.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588179
  • [Keywords] NOTNLM ; Hemangioblastoma / Mutation analysis / Von Hippel-Lindau disease
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77. Camargo RY, Tomimori EK: [Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma]. Arq Bras Endocrinol Metabol; 2007 Jul;51(5):783-92
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  • [Title] [Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma].
  • Conversely, nodules presenting benign ultrasonographic characteristics such as hyperechogenicity and a mixed sponge-like aspect, and a concordant cytology, have a negative predictive value of 96.6%.
  • Ultrasonography is also highly sensitive in the identification of suspicious cervical lymph nodes during the follow-up of patients with thyroid carcinoma, even when PCI is negative and serum thyroglobulin (Tg) levels are undetectable.
  • Tg measurement in the needle wash-out content is recommended as this has proven to be more sensitive than cytology in the diagnosis of cervical metastasis, especially where there is liquid content, and it is not affected by the presence of anti-Tg antibodies.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Carcinoma, Papillary / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Calcinosis / ultrasonography. Humans. Neoplasm Staging / methods. Predictive Value of Tests. Thyroglobulin / blood. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography. Ultrasonography, Doppler, Color. Whole Body Imaging

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  • (PMID = 17891242.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
  • [Number-of-references] 50
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78. Mayer A, Höckel M, Wree A, Leo C, Horn LC, Vaupel P: Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res; 2008 Jun 15;68(12):4719-26
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  • [Title] Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia.
  • Because benign tumors do not exhibit these traits, one might expect these entities to be neither hypoxic nor to induce the genetic hypoxia response program.
  • To test this hypothesis, an investigation of the oxygenation status of 17 leiomyomas and 1 leiomyosarcoma of the uterus using polarographic needle electrodes (Eppendorf pO(2) sensor) and the expression of hypoxia-related markers in biopsy specimens of the same tumors was carried out.
  • Uterine leiomyoma might therefore represent a state of oxygen-limited proliferation.
  • [MeSH-major] Anoxia / metabolism. Leiomyoma / metabolism. Leiomyosarcoma / metabolism. Oxygen / metabolism. Uterine Cervical Neoplasms / metabolism
  • [MeSH-minor] Adult. Antigens, Neoplasm / metabolism. Apoptosis. Basic Helix-Loop-Helix Transcription Factors / metabolism. Carbonic Anhydrases / metabolism. Cell Proliferation. Female. Glucose Transporter Type 1 / metabolism. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Immunoenzyme Techniques. In Situ Nick-End Labeling. Middle Aged. Myometrium / metabolism. Myometrium / pathology. Prospective Studies

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  • (PMID = 18559518.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Glucose Transporter Type 1; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / endothelial PAS domain-containing protein 1; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; S88TT14065 / Oxygen
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79. Zhou M, Magi-Galluzzi C: Clinicopathological features of prostate cancers detected after an initial diagnosis of 'atypical glands suspicious for cancer'. Pathology; 2010 Jun;42(4):334-8
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  • [Title] Clinicopathological features of prostate cancers detected after an initial diagnosis of 'atypical glands suspicious for cancer'.
  • BACKGROUND: A diagnosis of 'atypical glands suspicious for cancer' (ATYP) in prostate needle biopsy is associated with approximately a 40-50% risk of detecting prostate cancer in subsequent biopsies.
  • Pathological characteristics of prostate cancer following an initial diagnosis of ATYP are rarely studied.
  • DESIGN: We studied prostate biopsies with an initial diagnosis of ATYP.
  • Number of ATYP foci, presence of concomitant high grade prostatic intraepithelial neoplasia (HGPIN), date and diagnosis of repeat biopsies were recorded.
  • When radical prostatectomy was performed for confirmed prostate cancer, Gleason score, tumour volume, extraprostatic extension, seminal vesicle invasion, lymph node status, and surgical margins of resection status were also recorded.
  • RESULTS: Between 1992 and 2009, 239 patients biopsied at our institution carried a diagnosis of ATYP and underwent repeat follow-up biopsies.
  • Final repeat follow-up diagnoses were: prostate cancer in 122 (51.0%), ATYP in 15 (6.3%), HGPIN in 35 (14.6%), and benign prostatic tissue in 67 (28.0%) cases.
  • One patient presented with metastatic prostate cancer in a cervical lymph node.
  • Tumour volume was low in 42.8%, medium in 49.0%, and extensive in 8.2% of cases.
  • CONCLUSION: Most prostate cancers detected following an initial diagnosis of ATYP are clinically significant.
  • Patients with a diagnosis of ATYP should be followed up aggressively.
  • [MeSH-major] Adenocarcinoma / pathology. Precancerous Conditions / pathology. Prostate / pathology. Prostatic Intraepithelial Neoplasia / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 20438405.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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80. Paulino AC, Fowler BZ: Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol; 2005 Mar;22(2):89-101
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  • [Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.
  • This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.
  • From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.
  • The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.
  • Twenty-three (5.4%) patients developed a secondary neoplasm.
  • There were 14 malignant neoplasms in 13 (3.0%) and 14 benign neoplasms in 11 patients (2.6%).
  • The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.
  • For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.
  • The 14 second malignant neoplasms (SMN) were osteosarcoma in 3, breast carcinoma in 2, melanoma in 2, malignant fibrous histiocytoma in 1, dermatofibrosarcoma in 1, leiomyosarcoma in 1, mucoepidermoid carcinoma in 1, colon cancer in 1, chronic myelogenous leukemia in 1, and basal cell carcinoma in 1.
  • The 5- and 10-year overall survival rate after diagnosis of an SMN was 69.2%; it was 70% for children with a SMN at the edge or inside the RT field and 66.7% for those outside of the RT field.
  • The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.
  • Only 5 (36%) of the 14 benign tumors occurred in the RT field, with osteochondroma being the most common.
  • More than two-thirds of children with a radiation-induced malignancy are alive 10 years after the diagnosis of a SMN.
  • [MeSH-major] Neoplasms / radiotherapy. Neoplasms, Second Primary / etiology. Radiotherapy / adverse effects


81. Shi Y, Liu Z, Peng Z, Liu H, Yang K, Yao X: The diagnosis and treatment of Mullerian adenosarcoma of the uterus. Aust N Z J Obstet Gynaecol; 2008 Dec;48(6):596-600
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  • [Title] The diagnosis and treatment of Mullerian adenosarcoma of the uterus.
  • BACKGROUND: Adenosarcoma of the uterus is one of the rare types of gynaecological malignant tumours.
  • Poor awareness of it among clinicians makes it difficult to diagnose correctly and timely, so it is helpful to enrich and update our knowledge about the tumour with new information of patients.
  • AIM: To improve the level of diagnosis and treatment of Mullerian adenosarcoma of the uterus.
  • METHODS: The medical data of nine patients with Mullerian adenosarcoma of the uterus who were treated from May 1995 to March 2006 in our hospital were analysed retrospectively.
  • RESULTS: Patients typically presented with abnormal uterine bleeding, pain in the lower abdomen, enlargement of the uterus, a mass in the uterine cavity and/or a cervical neoplasm.
  • Microscopically, the glands were lined by benign or atypical glandular epithelium, together with sarcomatous stromal cells which showed characteristic structures of 'periglandular cuff' of increased cellularity and 'intraglandular polypoid projections'.
  • The primary diagnostic rate was 33.3% and the average interval from symptom onset to final diagnosis was 13 months and eight weeks for pre- and postmenopausal patients, respectively.
  • CONCLUSIONS: The most common symptom of adenosarcoma of the uterus is abnormal uterine bleeding.
  • [MeSH-major] Adenosarcoma / diagnosis. Mixed Tumor, Mullerian / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Uterine Cervical Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Age Factors. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome. Young Adult


82. Setzer M, Vatter H, Marquardt G, Seifert V, Vrionis FD: Management of spinal meningiomas: surgical results and a review of the literature. Neurosurg Focus; 2007;23(4):E14
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  • The Cox proportional hazards regression analysis showed three significant predictor variables for recurrence: invasion of the arachnoid/pia (p < 0.05; hazard ratio [HR] 1.8, 95% CI 1.2-3.6), Simpson resection grade (p < 0.012, HR 6.8, 95% CI 1.5-3.0), and histological tumor grade (Grade I; p < 0.001, HR 0.001-0.17).
  • CONCLUSIONS: Because of the excellent outcome of surgery for benign spinal meningiomas and the association between duration of symptoms and neurological compromise with a poor functional outcome, early operation is the treatment of choice.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Recovery of Function. Treatment Outcome

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  • (PMID = 17961038.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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83. Li QL, Chen FJ, Zeng ZY, Yang AK, Wu QL, Zhang HZ, Hou JH: [Expression and clinical significance of VEGF-C and Flt-4 in tongue squamous cell carcinoma]. Ai Zheng; 2006 Feb;25(2):235-40
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  • BACKGROUND & OBJECTIVE: Vascular endothelial growth factor-C (VEGF-C) could induce lymphangiogenesis in or around solid tumor, and is closely related with lymphatic metastasis.
  • METHODS: The expression of VEGF-C and Flt-4 in 99 specimens of TSCC and 17 specimens of benign tongue epithelial lesions was detected by LSAB immunohistochemistry.
  • RESULTS: The positive rates of VEGF-C and Flt-4 were significantly higher in TSCC than in benign tongue epithelial lesion (35.35% vs. 5.88%, and 40.40% vs. 5.88%, P<0.05).
  • The positive rate of VEGF-C was significantly higher in TSCC with cervical lymph node metastasis than in TSCC without metastasis (43.75% vs. 20%, P<0.05), and significantly lower in stage I-II TSCC than in stage III-IV TSCC (18.52% vs. 41.67%, P<0.05).
  • CONCLUSIONS: The positive rates of VEGF-C and Flt-4 are significantly higher in TSCC than in benign tongue epithelial lesions.
  • The expression of VEGF-C is correlated with cervical lymph node metastasis and clinical stage.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Tongue Neoplasms / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Leukoplakia, Oral / metabolism. Leukoplakia, Oral / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Prognosis. Survival Rate

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  • (PMID = 16480594.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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84. Sanati S, Huettner P, Ylagan LR: Role of ProExC: a novel immunoperoxidase marker in the evaluation of dysplastic squamous and glandular lesions in cervical specimens. Int J Gynecol Pathol; 2010 Jan;29(1):79-87
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  • [Title] Role of ProExC: a novel immunoperoxidase marker in the evaluation of dysplastic squamous and glandular lesions in cervical specimens.
  • Our purpose was to evaluate the sensitivity, specificity, and predictive value of ProExC in dysplastic squamous and glandular lesions of the cervix.
  • ProExC had sensitivity, specificity, and positive and negative predictive value of 89%, 100%, 100%, and 82%, respectively, for distinguishing high-grade squamous intraepithelial lesion from squamous metaplasia, and 93%, 100%, 100%, and 98%, respectively, for distinguishing adenocarcinoma in situ from reactive benign endocervix.
  • ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia in histologic sections.
  • ProExC may eventually be used in conjunction with morphologic and human papillomavirus evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cervical Intraepithelial Neoplasia / diagnosis. Immunoenzyme Techniques. Uterine Cervical Dysplasia / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / biosynthesis. Cell Cycle Proteins / biosynthesis. DNA Topoisomerases, Type II / biosynthesis. DNA-Binding Proteins / biosynthesis. Female. Humans. Middle Aged. Minichromosome Maintenance Complex Component 2. Nuclear Proteins / biosynthesis. Sensitivity and Specificity. Young Adult

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  • (PMID = 19952938.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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85. Lemaire A, Nikolic I, Petersen T, Haney JC, Toloza EM, Harpole DH Jr, D'Amico TA, Burfeind WR: Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate. Ann Thorac Surg; 2006 Oct;82(4):1185-9; discussion 1189-90
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  • [Title] Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate.
  • Pathology included lung cancer (n = 1,459), metastatic disease (n = 78), lymphoma (n = 51), and other benign disease (n = 557).
  • Thirty-two (57%) of the false negatives were due to metastatic disease in lymph nodes not normally biopsied during cervical mediastinoscopy (levels 5, 6, 8, or 9).
  • [MeSH-major] Lung Neoplasms / diagnosis. Mediastinoscopy. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. False Negative Reactions. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neck. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16996905.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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86. Suárez-Fente V, Llorente-Pendás JL, Gómez-Martínez J, García-González LA, López-Alvarez F, Suárez-Nieto C: [Primary tumours of the parapharyngeal space. Our experience in 51 patients]. Acta Otorrinolaringol Esp; 2009 Jan-Feb;60(1):19-24
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  • [Transliterated title] Tumores primarios del espacio parafaríngeo. Nuestra experiencia en 51 pacientes.
  • The aim of this study is to present our experience with the diagnosis and therapies for these tumours.
  • RESULTS: Seventy percent of the parapharyngeal space neoplasms were benign and thirty percent malignant.
  • Pleomorphic adenoma was the most common neoplasm (37 %), followed by miscellaneous benign tumours (34 %), paraganglioma (21 %), and neurogenic tumours (8 %).
  • Surgery was chosen in all case, with the transcervical approach used in 32 cases, the cervical-transparotid approach in 13 cases, the transmandibular approach in 4 cases (with mandibulectomy in 1 patient), the transoral approach in 1 case, and the infratemporal fossa approach in 1 case.
  • [MeSH-major] Pharyngeal Neoplasms

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  • (PMID = 19268125.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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87. Kim TY, Hong SJ, Kim JM, Kim WG, Gong G, Ryu JS, Kim WB, Yun SC, Shong YK: Prognostic parameters for recurrence of papillary thyroid microcarcinoma. BMC Cancer; 2008;8:296
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  • Recurrence was observed in 8 of 166 patients (0.5%) treated with total or near-total thyroidectomy; gender (P = 0.02) and presence of lateral cervical node metastases at initial surgery (P = 0.01) were associated with recurrence.
  • Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables CONCLUSION: PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Neoplasm Recurrence, Local / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Sex Factors. Thyroglobulin. Thyrotropin

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  • [Cites] Surg Today. 2001;31(9):763-7 [11686552.001]
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  • (PMID = 18851763.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
  • [Other-IDs] NLM/ PMC2576338
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88. Rosário PW, Tavares Júnior WC, Biscolla RP, Purisch S, Maciel RM: [Usefulness of neck ultrasonography in the follow-up of patients with differentiated thyroid cancer]. Arq Bras Endocrinol Metabol; 2007 Jun;51(4):593-600
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  • [Transliterated title] Emprego da ultra-sonografia cervical no seguimento de pacientes com carcinoma diferenciado de tireóide.
  • Neck ultrasonography (US) is recommended for the assessment of all patients with thyroid carcinoma after initial therapy, since even low-risk patients with undetectable stimulated thyroglobulin (Tg) may present cervical metastases.
  • Cervical lymph nodes with a diameter > 5 mm presenting thin calcifications and/or cystic degeneration have almost always a malignant etiology.
  • In the absence of these characteristics, a round shape and the absence of an echogenic hilum are "suspicious" findings, whereas elongated lymph nodes with a visible echogenic hilum are considered benign.
  • Doppler flow analysis helps with the differential diagnosis, usually revealing peripheral or mixed hypervascularization in malignant cases.
  • [MeSH-major] Carcinoma, Papillary / ultrasonography. Lymph Nodes / ultrasonography. Neck / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Follow-Up Studies. Humans. Lymphatic Metastasis. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 17684621.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 39
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89. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14
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  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.
  • [MeSH-major] Osteoblastoma / surgery. Osteoma, Osteoid / surgery. Spinal Neoplasms / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Humans. Male. Minimally Invasive Surgical Procedures / methods. Pain Measurement. Prognosis. Recovery of Function. Risk Assessment. Stereotaxic Techniques. Thoracic Vertebrae. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.
  • When the lesion is placed in the cervical and thoracic spine the goal is to decompress spinal cord and reach the stability of the spine.
  • [MeSH-major] Neurosurgical Procedures / methods. Osteoblastoma / surgery. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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91. Milas M, Shin J, Gupta M, Novosel T, Nasr C, Brainard J, Mitchell J, Berber E, Siperstein A: Circulating thyrotropin receptor mRNA as a novel marker of thyroid cancer: clinical applications learned from 1758 samples. Ann Surg; 2010 Oct;252(4):643-51
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  • In initial studies, the detection of circulating DTC cells by thyrotropin receptor (TSHR) mRNA measurement distinguished benign from malignant thyroid diseases.
  • METHODS: TSHR mRNA was measured by quantitative RT-PCR from blood drawn perioperatively in patients undergoing thyroid surgery (n = 526), postoperatively in patients undergoing DTC follow-up (n = 418) and in patients monitored for known benign disease (n = 151).
  • The reference range and applications for TSHR mRNA were previously defined from 663 samples from patients with normal, benign, and malignant thyroid disease.
  • RESULTS: In patients with follicular neoplasms or suspicious cytology, preoperative TSHR mRNA >1 ng/μg had 96% predictive value for DTC, whereas 95% of patients with undetectable mRNA and benign thyroid sonography had benign disease.
  • In patients with DTC, elevated TSHR mRNA levels became undetectable in all patients (n = 64) on the first postoperative day, except in 5 who manifested persistent or recurrent cervical disease within the year.
  • It is particularly useful in guiding appropriate initial surgery for follicular neoplasms.
  • [MeSH-major] Biomarkers / blood. RNA, Messenger / blood. Receptors, Thyrotropin / genetics. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Autoantibodies / blood. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / blood. Prospective Studies. Reverse Transcriptase Polymerase Chain Reaction. Thyroglobulin / immunology

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  • (PMID = 20881771.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biomarkers; 0 / RNA, Messenger; 0 / Receptors, Thyrotropin; 9010-34-8 / Thyroglobulin
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92. Dominical VM, Cavellani CL, Rocha LP, Corrêa RR, Pereira Gde A, Teixeira Vde P: Chagas disease and gynecologic neoplasias. Ann Diagn Pathol; 2010 Oct;14(5):337-40
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  • [Title] Chagas disease and gynecologic neoplasias.
  • The objective was to determine the occurrence of gynecologic neoplasia (GN) and demographic characteristics in patients with Chagas disease (CD).
  • The most common benign neoplasm was uterine leiomyoma, and malignant, carcinoma of the cervix.
  • [MeSH-major] Carcinoma / pathology. Chagas Disease / pathology. Leiomyoma / pathology. Trypanosoma cruzi. Uterine Cervical Neoplasms / pathology. Uterine Neoplasms / pathology


93. Wang CP, Chang YL, Ko JY, Cheng CH, Yeh CF, Lou PJ: Desmoid tumor of the head and neck. Head Neck; 2006 Nov;28(11):1008-13
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  • [Title] Desmoid tumor of the head and neck.
  • BACKGROUND: [corrected] Desmoid tumors are rare benign tumors but have a tendency toward local recurrence after resection because of their infiltrative growth and frequent entrapment of vital structures in the head and neck region.
  • METHODS: Twenty-four patients (9 male and 15 female; median age, 33 years; range, 0-66 years) with a desmoid tumor of the head and neck (neck, 15 patients; head, 9 patients) treated from 1990 to 2004 were retrospectively analyzed.
  • In the neck, 8 tumors were around the superficial layer of deep cervical fascia, whereas 4 tumors of the neck involved the prevertebral fascia and 2 involved brachial plexus.
  • RESULTS: Twenty patients received complete resection of the tumor, but the section margin was positive in 8 patients, of which 6 patients remained free of disease in a period of 13 to 105 months.
  • Two patients underwent partial resection of the tumor because of brachial plexus involvement.
  • The hypopharygneal tumor in a newborn had spontaneously complete regression, and tracheostomy was closed at the age of 6 years.
  • One patient remained with stable disease for 14 months after biopsy of the tumor without excision.
  • Surgical resection of the tumor with close observation is suggested even if the section margin is positive.
  • If a desmoid tumor cannot be removed grossly, regression or arrested growth of the remaining tumor is expected.
  • Radiotherapy might be reserved for a growing tumor.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 16983695.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Maung KH, Low C, Knight LC, Cullinane CJ: Multiple cervical bronchogenic cysts. J Laryngol Otol; 2006 Feb;120(2):145-7
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  • [Title] Multiple cervical bronchogenic cysts.
  • Bronchogenic cysts are rare, benign, congenital lesions that occur as a result of aberrant development of the tracheobronchial tree during embryogenesis.
  • In a few instances, they appear within the neck mimicking a neoplasm and, depending on their size and site, may also cause acute upper respiratory obstruction.
  • We describe a case of two cervical bronchogenic cysts adjacent to the larynx in a child who presented with a hoarse voice.
  • [MeSH-major] Bronchogenic Cyst / diagnosis. Laryngeal Diseases / diagnosis

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  • (PMID = 16480550.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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95. Aust W, Bloching M, Holzhausen HJ, Kösling S, Knipping S: [Tuberculosis of the parotid gland]. HNO; 2008 Apr;56(4):425-8
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  • [Transliterated title] Tuberkulose in der Glandula parotidea.
  • The different tumours of the parotid gland can be divided in benign or malignant tumours, regional inflammations and enlarged lymph nodes.
  • We report on a 26-year-old male from Uganda with a slowly growing tumour of the right parotid gland for several months.
  • The CT scan showed a poorly defined intraparotideal tumour.
  • Ultrasonography revealed multiple enlarged cervical lymph nodes.
  • Suspecting a neoplasm of the parotid gland we decided to perform a superficial parotidectomy for histological examination.
  • It must be considered as a differential diagnosis of parotid enlargements.
  • [MeSH-major] Mycobacterium tuberculosis / isolation & purification. Parotid Diseases / diagnosis. Parotid Diseases / microbiology. Tuberculosis / diagnosis. Tuberculosis / microbiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Parotid Neoplasms / diagnosis

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  • [Cites] HNO. 2002 Apr;50(4):332-8 [12063691.001]
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  • (PMID = 17380314.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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96. Falavigna A, Righesso O, Volquind D, Teles AR: Intramuscular myxoma of the cervical paraspinal muscle. Eur Spine J; 2009 Jul;18 Suppl 2:245-9
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  • [Title] Intramuscular myxoma of the cervical paraspinal muscle.
  • Myxoma is a neoplasm of mesenchymal origin composed of undifferentiated stellate cells in a myxoid stroma.
  • This tumor can develop in a variety of locations.
  • Only ten cases of these benign tumors involving the neck muscles were reported in literature.
  • A 64-year-old woman presented with occipital and neck pain over 5 years noted an expansive painful lesion located at posterior cervical region with progressive volume increase in the last 12 months.
  • Tumor total removal was performed through normal muscle margins and the vertebral periosteum was scraped.
  • The tumor was encapsulated, lobulated with a gray-white appearance.
  • The histological examination yielded the diagnosis of intramuscular myxoma.
  • In conclusion, although rare, intramuscular myxoma should be included in differential diagnosis of cervical paraspinal tumors.
  • Despite its benign characteristics, local recurrence was reported after subtotal resection.
  • Tumor total removal should be the goal of surgery.
  • [MeSH-major] Cervical Vertebrae. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Myxoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19301043.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2899565
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97. Sakurai H, Suzuki Y, Nonaka T, Ishikawa H, Shioya M, Kiyohara H, Katoh H, Nakayama Y, Hasegawa M, Nakano T: FDG-PET in the detection of recurrence of uterine cervical carcinoma following radiation therapy--tumor volume and FDG uptake value. Gynecol Oncol; 2006 Mar;100(3):601-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG-PET in the detection of recurrence of uterine cervical carcinoma following radiation therapy--tumor volume and FDG uptake value.
  • PURPOSE: We evaluated the use of positron emission tomography (PET) with fluorine-18-labeled fluoro-2-deoxy-d-glucose (FDG) in follow-up study after radiation therapy in patients with uterine cervical carcinoma.
  • Rationale for FDG-PET was the presence of symptoms in 6 patients, abnormal serum tumor marker values in 13, abnormal lesions on other diagnostic imaging modalities in 19, and patient request in 2.
  • Maximum tumor diameter and tumor volume in the corresponding disease were estimated by computed tomography (CT) or magnetic resonance imaging (MRI).
  • Three false-positive cases were a localized pneumonitis, a benign pubic bone fracture, and a fibrosis after interstitial brachytherapy.
  • Regarding tumor volume measurement, good correlation between maxSUV on FDG-PET and tumor volume was obtained (lung metastases, P = 0.03; extrapelvic nodes, P < 0.0001).
  • CONCLUSION: FDG-PET is a useful tool for the detection of extrapelvic lesions during the follow-up period after radiation therapy for cervical cancer.
  • This study suggests that FDG uptake is associated with tumor volume, and FDG-PET has limitations in the detection of lesions less than 1 cm3 or microscopic disease.
  • Careful diagnostic agreement between PET and CT/MRI for positive but benign lesions, such as inflammation and bone fracture, remains important.
  • [MeSH-major] Fluorodeoxyglucose F18. Neoplasm Recurrence, Local / radionuclide imaging. Radiopharmaceuticals. Uterine Cervical Neoplasms / radionuclide imaging


98. Gombos Z, Xu X, Chu CS, Zhang PJ, Acs G: Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res; 2005 Dec 1;11(23):8364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix.
  • PURPOSE: Lymphatic invasion and nodal metastasis plays a major role in the spread of cervical cancer; however, little is known about the mechanisms whereby tumor cells enter the lymphatic system.
  • EXPERIMENTAL DESIGN: We examined the intra- and peritumoral lymphatic vessel density (LVD) using D2-40 immunohistochemistry in 111 cervical squamous cell carcinomas and correlated them with vascular endothelial growth factor (VEGF)-C expression, clinicopathologic tumor features, and outcome.
  • RESULTS: Compared with benign cervix, intratumoral and peritumoral LVD was significantly increased (P < 0.0001).
  • High peritumoral, but not intratumoral, LVD showed significant correlation with high tumor stage, lymphatic invasion, and nodal metastasis.
  • CONCLUSIONS: Our findings suggest a potential role for VEGF-C in tumor-induced lymphangiogenesis represented by high peritumoral LVD, which may be one of the mechanisms leading to lymphatic invasion and metastatic spread.
  • High peritumoral LVD may be an independent prognostic factor in early-stage cervical cancer.
  • [MeSH-major] Lymph Nodes / pathology. Lymphatic Vessels / pathology. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology. Vascular Endothelial Growth Factor C / metabolism
  • [MeSH-minor] Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Female. Humans. Lymphangiogenesis. Lymphatic Metastasis. Neoplasm Staging. Neoplasms / metabolism. Neoplasms / pathology. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Prognosis. Survival Rate


99. Derin AT, Güney K, Turhan M, Erdoğan A, Ağirdir BV: Giant cervical lipoma invading carotid artery: a case report. Kulak Burun Bogaz Ihtis Derg; 2009 Jan-Feb;19(1):28-31
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  • [Title] Giant cervical lipoma invading carotid artery: a case report.
  • Lipomas are one of the most frequently encountered benign tumors in any location.
  • In this manuscript we report a case of cervical giant lipoma surrounding and infiltrating the common carotid artery which was treated by grafting carotid artery, and our diagnostic work-up and treatment procedure are discussed in the light of the literature.
  • [MeSH-major] Carotid Artery, Common / pathology. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Blood Vessel Prosthesis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 19793044.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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100. Ko ML, Lin HW, Chen SC, Pan HS: Should cystoscopy be routinely performed after laparoscopy-assisted vaginal hysterectomy? Minim Invasive Ther Allied Technol; 2008;17(3):195-9
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  • There were eighty patients who underwent LAVH for benign tumors of the uterus (adenomyosis and myoma), uterine prolapse, persistent intraepithelial neoplasm of the cervix (CIN3) and cervical carcinoma in situ (CIS).
  • From among the 80 patients who underwent LAVH, 52 had myoma, 19 had adenomyosis, six patients had uterine prolapse, one had CIS and seven patients were diagnosed to have CIN3.
  • [MeSH-major] Cystoscopy / methods. Hysterectomy, Vaginal / adverse effects. Intraoperative Complications / diagnosis. Laparoscopy / adverse effects
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hematuria / etiology. Humans. Middle Aged. Postoperative Complications / prevention & control. Retrospective Studies. Stents. Ureter / injuries. Ureter / surgery. Ureteral Obstruction / diagnosis. Ureteral Obstruction / etiology. Ureteral Obstruction / surgery

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  • (PMID = 18608998.001).
  • [ISSN] 1365-2931
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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