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Items 1 to 33 of about 33
1. Zakrzewski K, Biernat W, Liberski PP, Polis L, Nowoslawska E: Pilocytic astrocytoma as a predominant component of a recurrent complex type DNT. Folia Neuropathol; 2009;47(3):284-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dysembryoplastic neuroepithelial tumour (DNT) is a benign lesion of the cerebral hemispheres usually presenting minimal biological activity after surgical excision.
  • We report an unusual case of a 7-year-old girl with a temporal lobe DNT, which recurred four years after subtotal resection of the tumour.
  • In the recurrent lesion we identified pilocytic astrocytoma (PA) as a predominant component of the tumour.
  • Clinical presentation of the primary tumour consisted of partial simple seizures, while the recurrent tumour manifested with headache and vomiting.
  • We conclude that patients with incompletely removed DNT may suffer local recurrence of that tumour.
  • In rare cases development of a secondary, histologically different neoplasm may also occur.

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  • (PMID = 19813149.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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2. Andrychowski J, Taraszewska A, Czernicki Z, Jurkiewicz J, Netczuk T, Dabrowski P: Ten years observation and treatment of multifocal pilocytic astrocytoma. Folia Neuropathol; 2009;47(4):362-70
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  • It is a benign, generally well-delineated, WHO grade I tumour with favorable prognosis, which makes it different from diffuse astrocytomas, classified as higher grades of malignancy.
  • A case study of PA was presented in a young female patient, observed and treated at the Neurosurgical Department for the period of 10 years, during which time she had frequent surgical procedures due to recurrence and dissemination of the tumour.
  • Neuroradiological study revealed cerebral tumour in the right temporal lobe, then the first temporal lobe surgery followed by re-operation and radiotherapy was performed.
  • After 5 years local recurrence of the tumour appeared in the right temporal region.
  • The patient was operated and the tumour was totally removed.
  • Initially, the histopathological diagnosis of ganglioglioma was suggested for primary tumour, finally the diagnosis of pilocytic astrocytoma for both recurrent and primary tumour was established.
  • The spinal tumour was surgically treated in both locations; the last operation was done 10 years after surgery of the primary temporal lobe tumour.
  • Histopathological examinations of the excised foci from spinal canal revealed neoplasm consistent with WHO grade I pilocytic astrocytoma.
  • The presented case indicates that despite the spread of the neoplastic process, a histopathologically benign tumour (WHO I grade) allows for long-term survival and observation period.
  • Unfortunately, multifocal tumour involving midline structures causes major neurological symptoms and deficits.

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  • (PMID = 20054789.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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3. Navas M, Pedrosa-Sánchez M, Martínez-Flórez P, Carrasco R, Pascual JM, Sola RG: [Giant cavernous sinus haemangioma. Case report]. Neurocirugia (Astur); 2009 Oct;20(5):461-6

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  • [Transliterated title] Hemangioma gigante del seno cavernoso. Caso clínico.
  • INTRODUCTION: Intracranial haemangioma is a benign vascular tumor which seldom affects the cavernous sinus region, being it frequently misdiagnosed as a meningioma.
  • The tumor was partially removed through a left pterional approach, leaving an intraselar remnant.
  • This entity represents a neurosurgical challenge, due to the complexity of this anatomical region and the trend of the tumour to bleed during its dissection.
  • [MeSH-minor] Cerebral Angiography. Diagnosis, Differential. Female. Hemangioma, Cavernous, Central Nervous System / complications. Hemangioma, Cavernous, Central Nervous System / diagnosis. Hemangioma, Cavernous, Central Nervous System / epidemiology. Hemangioma, Cavernous, Central Nervous System / radiography. Hemangioma, Cavernous, Central Nervous System / surgery. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Middle Aged. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19830369.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 23
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4. Gleeson H, Amin R, Maghnie M: 'Do no harm': management of craniopharyngioma. Eur J Endocrinol; 2008 Dec;159 Suppl 1:S95-9
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  • Although histology is benign, the tumour can be clinically aggressive with local invasion and frequent recurrences.
  • This case highlights both the challenge of managing hyperphagia and morbid obesity and the importance of initial treatment preserving existing hypothalamic function and the need to avoid tumour recurrence and further surgery.
  • He developed a left hemiplegia, and a subsequent cerebral angiogram identified multiple stenoses of the Circle of Willis with a Moyamoya appearance secondary to radiotherapy.

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  • (PMID = 18775978.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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5. Montano N, Doglietto F, Lauriola L, Signorelli F, Pallini R: Solitary fibrous tumour of the IV ventricle. Br J Neurosurg; 2010 Aug;24(4):495-6

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  • [Title] Solitary fibrous tumour of the IV ventricle.
  • BACKGROUND: Solitary Fibrous Tumour (SFT) is a rare tumour occurring mainly in the pleural cavity, with less than 100 cases reported in the Central Nervous System, where it typically presents as a meningeal-based lesion.
  • SFTs of the fourth ventricle are usually benign tumours.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Solitary Fibrous Tumors / diagnosis

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  • (PMID = 20726760.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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6. Taranath A, Lam A, Wong CK: Desmoplastic infantile ganglioglioma: a questionably benign tumour. Australas Radiol; 2005 Oct;49(5):433-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic infantile ganglioglioma: a questionably benign tumour.
  • Desmoplastic infantile ganglioglioma is a rare intracranial tumour of childhood that involves the cerebral cortex and the leptomeninges.
  • Pathologically, this rare intracranial tumour shows glial and ganglionic differentiation, accompanied by an extreme desmoplastic reaction.
  • These are low-grade neoplasms that are questionably benign.


7. Ortega-Martínez M, Cabezudo-Artero JM, Fernández-Portales I, Pimentel JJ, Gómez de Tejada R: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien); 2007 Dec;149(12):1229-36; discussion 1236-7
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  • [Title] Diffuse leptomeningeal seeding from benign choroid plexus papilloma.
  • Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional.
  • Neither the initial tumour nor the recurrence showed malignant histological features.
  • We review the literature concerning leptomeningeal dissemination of benign choroid plexus papillomas.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Fourth Ventricle / surgery. Meningeal Neoplasms / secondary. Neoplasm Seeding. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Disease Progression. Fatal Outcome. Female. Humans. Ki-67 Antigen / analysis. Laminectomy. Magnetic Resonance Imaging. Meninges / pathology. Reoperation. S100 Proteins / analysis

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  • (PMID = 17924056.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
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8. Arcos A, Serramito R, Santín JM, Prieto A, Gelabert M, Rodriguez-Osorio X, Reyes R: Meningioangiomatosis: clinical-radiological features and surgical outcome. Neurocirugia (Astur); 2010 Dec;21(6):461-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meningioangiomatosis (MA) is a rare, benign neoplastic disorder involving the cortex and leptomeninges, the sporadic form, commonly presents as refractory localization-related epilepsy, but could be asymptomatic especially in older patients.
  • Magnetic Resonance Imaging (MRI) erroneously suggests meningioma, lowgrade tumour or vascular malformations.
  • [MeSH-major] Angiomatosis. Cerebral Cortex. Meningeal Neoplasms

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  • (PMID = 21165543.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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9. Li YM, Li WQ, Pan Y, Lu YC, Long NY, Tao XF, Yu HY: Rosette-forming glioneuronal tumour of the fourth ventricle with previous intratumoural haemorrhage: case report and review of the literature. J Int Med Res; 2009 May-Jun;37(3):958-66
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  • [Title] Rosette-forming glioneuronal tumour of the fourth ventricle with previous intratumoural haemorrhage: case report and review of the literature.
  • The case is reported of a rosette-forming glioneuronal tumour of the fourth ventricle (RGTFV) in a 27-year-old male.
  • The tumour showed evidence of previous intra-tumour haemorrhage, with heterogeneous enhancement after contrast administration.
  • The detailed clinical, radiological and pathological features in this patient are described and compared with existing literature on this type of tumour.
  • Despite benign histological features and a reported favourable post-operative course, there is still limited clinical experience with this type of tumour, however intratumoural haemorrhage may result in morbidity and mortality.
  • [MeSH-major] Cerebral Ventricle Neoplasms / complications. Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Hemorrhage / complications

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  • (PMID = 19589282.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 18
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10. Asioli S, Senetta R, Maldi E, D'Ambrosio E, Satolli MA, Bussolati G, Cassoni P: "Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung. Virchows Arch; 2007 May;450(5):591-4
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  • [Title] "Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung.
  • Lung "metastases" of benign meningiomas are rarely described events of biological and clinical interest.
  • Anamnesis revealed that the patient underwent a surgical resection of cerebral meningioma 12 years before.
  • The morphological and immunohistochemical features of this lesion, together with the similarity with the original cerebral tumour and its indolent evolution, led to a final diagnosis of "benign" meningioma metastatic to the lung.
  • They represent a typical example of "benign" tumours that may implant to the lung similar to other tumours, definitely considered benign but reported to rarely present unusual secondary localization.
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Neoplasm Metastasis / pathology. Tomography, X-Ray Computed

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  • (PMID = 17431673.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Duclos C, Bonnin N, Merlin E, Viorel A, Lacombe P, Dalens H, Chiambaretta F, Deméocq F, Chazal J, Kanold J: [Benign but not harmless intracranial hypertension: a case report]. Arch Pediatr; 2010 Dec;17(12):1677-81
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  • [Title] [Benign but not harmless intracranial hypertension: a case report].
  • Benign intracranial hypertension (BIH) is characterized as an intracranial pressure increase occurring in the absence of brain tumour, sinus thrombosis or hydrocephaly.
  • Cerebrospinal fluid pressure was 70cm water, without enlargement of the cerebral ventricles.
  • This case shows that BIH, which is not a well-known disorder, is incorrectly referred to as benign: both prompt diagnosis and proper management are of major importance.

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21087845.001).
  • [ISSN] 1769-664X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Diuretics; O3FX965V0I / Acetazolamide
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12. Darwazah AK, Shoeb J, Eissa SS: Pedunculated endocardial left ventricular fibroma presenting with cerebral and bilateral peripheral embolization. Ann Thorac Surg; 2010 Mar;89(3):965-7

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  • [Title] Pedunculated endocardial left ventricular fibroma presenting with cerebral and bilateral peripheral embolization.
  • Left ventricular fibroma is a rare benign tumour of the heart.
  • [MeSH-minor] Adult. Humans. Infarction, Middle Cerebral Artery / complications. Infarction, Middle Cerebral Artery / diagnosis. Magnetic Resonance Imaging. Male

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172169.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Koch HJ, Roeber S, Zimmermann UW, Schäfer C, Villarrubia V, Kuchelmeister K, Schachenmayr W, Bogdahn U, Steinbrecher A: [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]. Wien Med Wochenschr; 2005 Aug;155(15-16):360-4
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  • [Title] [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].
  • Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes.
  • Meningeal spread of this tumour is very rarely observed.
  • This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse.
  • [MeSH-major] Cerebellopontine Angle. Melanocytes / pathology. Melanoma. Meningeal Neoplasms. Meninges. Neoplasm Seeding
  • [MeSH-minor] Administration, Oral. Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Arachnoid. Cerebellar Diseases / diagnosis. Cerebellar Neoplasms / diagnosis. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Pia Mater. Radiotherapy Dosage. Time Factors

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  • (PMID = 16160923.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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14. Gávai M, Váradi V, Belics Z, Papp Z: [Fetal ischaemic brain injury in the second trimester of pregnancy]. Orv Hetil; 2006 Aug 20;147(33):1567-71
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  • Each of these factors is supposed to be a major precursor for neurological and intellectual impairment, and cerebral palsy (CP) in later life.
  • Antenatal rather than intrapartum factors are now emerging as the major determinants of cerebral palsy.
  • In this case report maternal trauma, benign tumour, severe anaemia and fetal cerebral vascular malformation are supposed as causative factors in intrauterine periventricular leukomalacia resulting from hypoxic-ischaemic injury.

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  • (PMID = 17037679.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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15. Rajesh LS, Jain D, Radotra BD, Banerjee AK, Khosla VK, Vasishta RK: Central neurocytoma: a clinico-pathological study of eight cases. Indian J Pathol Microbiol; 2006 Oct;49(4):543-5
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  • Central neurocytomas are benign neuronal tumours generally found in the lateral or third ventricles.
  • The tumour in extraventricular location showed atypical features.
  • The present series highlights the characteristic clinical and pathological findings of this rare brain tumour.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / physiopathology. Neurocytoma / pathology. Neurocytoma / physiopathology. Neurons / metabolism

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  • (PMID = 17183847.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins; 0 / Synaptophysin
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16. Ulivieri S, Oliveri G: Intraventricular neurocytoma: case report. Pathologica; 2007 Oct;99(5):309-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraventricular neurocytoma is a rare, usually benign tumour of neuronal differentiation, recently recognized as a clinico-pathological entity in comparison to the other intraventricular tumours.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurocytoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Corpus Callosum / pathology. Craniotomy. Humans. Male. Synaptophysin / analysis

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  • (PMID = 18354953.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Synaptophysin
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17. Fayed N, Modrego PJ: The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumours. J Neurooncol; 2005 May;72(3):261-5
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  • The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours.
  • We included 55 patients diagnosed with single brain tumour by CT and MRI, and final histopathological verification of the tumour type: 25 were low-grade gliomas, 8 anaplastic gliomas, 11 glioblastomas, and 11 solitary metastases.
  • In MRS, we found significant differences in Choline/Creatine ratios in relation to the tumour type with the highest values in high-grade gliomas and metastases.
  • We found no significant differences in the relative cerebral blood volume (rCBV) for every type of tumour.
  • The mean rCBV was 1.24 for benign tumours and 1.5 for the malignant ones(1.24 for low-grade gliomas, 1.91 for anaplastic gliomas, 1.03 for glioblastomas, and 1.57 for metastases).
  • Perfusion MRI has not demonstrated predictive power to distinguish malignant from benign tumours.
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / chemistry. Astrocytoma / diagnosis. Astrocytoma / pathology. Blood Volume / physiology. Child. Child, Preschool. Choline / metabolism. Creatine / metabolism. Creatinine / metabolism. Female. Glioma / chemistry. Glioma / diagnosis. Glioma / pathology. Humans. Lactates / metabolism. Male. Middle Aged. Neoplasm Metastasis / diagnosis. ROC Curve. Tomography, X-Ray Computed

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  • (PMID = 15937650.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; AYI8EX34EU / Creatinine; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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18. van Muiswinkel KW, Meuzelaar JJ: [Papillary fibroelastoma: a rare cause of brain embolism]. Ned Tijdschr Geneeskd; 2008 Jul 5;152(27):1532-6
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  • Neurological examination raised the suspicion of cerebral ischaemia due to an embolism.
  • One patient had a stalked tumour of the mitral valve and the other had a spherical tumour of the aortic valve which was clearly seen on ultrasound examination, both tumours presumably a papillary fibroelastoma.
  • Papillary fibroelastoma is a rare benign primary cardiac tumour that is usually noticed when it has caused cerebrovascular ischaemia.
  • Surgical excision of the tumour is the treatment of choice.

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  • (PMID = 18681364.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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19. Miles KA: Perfusion imaging with computed tomography: brain and beyond. Eur Radiol; 2006 Nov;16 Suppl 7:M37-43
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  • Within neuroradiology, perfusion CT has attracted interest in the assessment of acute stroke but can also be used to assess secondary injury in head trauma and as an adjunct to CT angiography to evaluate cerebral spasm in subarachnoid haemorrhage.
  • Within oncology, perfusion CT provides an imaging correlate for tumour vascularity that can be used to discriminate benign and malignant lesions, as an indicator of tumour aggressiveness, to reveal occult tumour and improve the delineation of tumours during radiotherapy planning, and as a functional assessment of tumour response to therapy.

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  • (PMID = 18655265.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 41
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20. Havu-Aurén K, Kiiski J, Lehtiö K, Eskola O, Kulvik M, Vuorinen V, Oikonen V, Vähätalo J, Jääskeläinen J, Minn H: Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. Eur J Nucl Med Mol Imaging; 2007 Jan;34(1):87-94
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  • Boron neutron capture therapy (BNCT) is a chemically targeted form of radiotherapy requiring increased concentration of boron-10 in tumour tissue.
  • Tracer input function and cerebral blood volume were measured.
  • [(18)F]FBPA uptake in tumour and brain was assessed with a three-compartmental model and graphical analysis.
  • These, together with standardised uptake values (SUVs), were used to define tumour-to-brain [(18)F]FBPA tissue activity gradients.
  • Maximum SUV was two- to fourfold higher in tumour as compared with normal brain and independent of NF2 status.
  • The increased uptake was due to higher transport of [(18)F]FBPA in tumour.
  • In multiple-time graphical analysis (MTGA, Gjedde-Patlak plot) the tumour-to-brain [(18)F]FBPA influx constant (K (i) -MTGA) ratios varied between 1.8 and 5.4 in NF2-associated tumours while in sporadic tumours the ratio was 1-1.4.
  • Based on our results on tumour uptake of [(18)F]FBPA, some of these benign neoplasms may be amenable to BNCT.

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  • (PMID = 16896669.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiopharmaceuticals; 133921-60-5 / 4-borono-2-fluorophenylalanine; 47E5O17Y3R / Phenylalanine
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21. Pamir MN, Kilic T, Ozek MM, Ozduman K, Türe U: Non-meningeal tumours of the cavernous sinus: a surgical analysis. J Clin Neurosci; 2006 Jul;13(6):626-35
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  • A retrospective analysis of 42 cases of benign non-meningeal tumours of the cavernous sinus operated on at Marmara University between April 1992 and April 2003 is presented.
  • Twenty-nine percent of patients developed complications, namely cerebrospinal fluid fistula, haematoma, hydrocephalus, diabetes insipidus, cerebral infarction and cranial nerve palsies.
  • Individual tumour characteristics are presented in the text.

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  • (PMID = 16860718.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Scotland
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22. Walter J, Kuhn SA, Brodhun M, Reichart R, Kalff R: Pulmonary meningioma and neurinoma associated with multiple CNS tumours in a patient with neurofibromatosis type 2. Clin Neurol Neurosurg; 2009 Jun;111(5):454-9
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  • OBJECTIVE: Neurofibromatosis type 2 (NF2) is a common neurocutaneous disorder that exhibits an autosomal dominant inheritance, with a mutation at chromosome 22q12.2.
  • RESULTS: The reported patient presented a de novo NF2 germline mutation (R341X) and displayed the Wishart-type of NF-2 since she is 11 years old, with a huge anaplastic biparietal falx meningioma and a tentorium meningioma and a tumour-associated parietal mass as well as hypacusis starting at the infant age of 3 years.
  • Moreover, recurrent pulmonary tumours developed and were classified as benign meningiomas and a single neurinoma.
  • No direct evidence concerning a relationship between the pulmonary and cerebral tumours could be drawn.


23. Fon LJ, Lioe TF, Mulligan KA, Johnston PG, McCormick D, Spence RA: Prognostic significance of glycoprotein pMQ1 in breast cancer. Br J Surg; 2006 Mar;93(3):309-14
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  • Cerebral metastases from breast cancer have also been found to contain pMQ1-positive cells.
  • The surrounding normal tissue margins and benign breast tissues always lacked pMQ1 expression.
  • CONCLUSION: pMQ1 appears to be a tumour-associated protein.
  • [MeSH-major] Breast Neoplasms / chemistry. Glycoproteins / analysis. Neoplasm Proteins / analysis
  • [MeSH-minor] Adult. Aged. Breast / chemistry. Female. Follow-Up Studies. Humans. Ki-67 Antigen / analysis. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Receptors, Estrogen / analysis. Tumor Suppressor Protein p53 / analysis

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 16392102.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; 0 / pMQ1 glycoprotein, human
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24. Mathews MS, Kim RC, Chang GY, Linskey ME: Klippel-Trenaunay syndrome and cerebral haemangiopericytoma: a potential association. Acta Neurochir (Wien); 2008 Apr;150(4):399-402; discussion 402
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  • [Title] Klippel-Trenaunay syndrome and cerebral haemangiopericytoma: a potential association.
  • Klippel-Trenaunay syndrome (KTS) a rare mesodermal phakomatosis consisting of capillary malformations, varicose veins, and limb hypertrophy, often associated with vascular malformations and benign tumours.
  • A 33-year-old male presented with headaches secondary to a previously diagnosed intracranial tumour.
  • Thus KTS may be associated with intracranial Haemangiopericytomas, a malignant vascular tumour.

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  • (PMID = 18297229.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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25. Petrovic NS, Grujicic D, Artiko VM, Sobic-Saranovic DP, Gajic MM, Jaksic E, Grajic MM, Antonovic OJ, Petrovic MN, Obradovic VB: Investigation of blood perfusion and metabolic activity of brain tumours in adults by using 99mTc-methoxyisobutylisonitrile. Nucl Med Commun; 2010 Nov;31(11):962-73
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  • OBJECTIVES: (i) To examine blood perfusion and metabolic activity of various brain tumours using radionuclide cerebral angiography (RCA) and single-photon emission tomography (SPET) after a single dose of Tc-methoxyisobutylisonitrile (MIBI). (ii) To examine if the inclusion of RCA can improve insight into the relative contribution of tumour perfusion to the uptake of MIBI shown by SPET, and to improve evaluation of tumour biology. (iii) To determine the value and the roles of MIBI in the management of brain tumour patients.
  • The control group consisted of nine volunteers with no evidence of organic cerebral disease.
  • Regions of interest of the tumour and normal brain tissue were drawn on RCA and both early and delayed SPET slices.
  • The following tumour/brain activity ratios have been calculated: (i) tumour perfusion index (P);.
  • RESULTS: Mean P of various brain tumours (low-grade gliomas 0.98, anaplastic gliomas 1.14, glioblastoma multiforme 1.20, metastases 1.09, lymphomas 1.08) differ little from each other and do not exceed maximal physiologic regional variations of cerebral perfusion (1.33), with the exception of meningioma (1.87, F=2.83, P=0.015).
  • Mean E of malignant brain tumours (8.3, n=31, 23 primary, eight secondary), except anaplastic gliomas (3.5, n=5), differed significantly (P=0.02) from those of benign gliomas (3, n=9) but not from that of meningioma (11.9, n=4).
  • The cut-off value for distinguishing malignant from benign lesions on the basis of E set at 4.8 resulted in sensitivity 67%, specificity 75%, accuracy 70%, positive predictive value 80% and negative predictive value 60%.
  • CONCLUSION: Integrated results of RCA and SPET with Tc-MIBI indicate that blood perfusion, blood-tumour barrier permeability and metabolic activity of the tumour are all very important for the resultant uptake shown by SPET.
  • [MeSH-major] Brain Neoplasms / blood supply. Brain Neoplasms / metabolism. Cerebral Angiography. Cerebrovascular Circulation. Technetium Tc 99m Sestamibi / metabolism. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 20802363.001).
  • [ISSN] 1473-5628
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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26. O'Brien DF, Crooks D, Mallucci C, Javadpour M, Williams D, du Plessis D, Broome J, Foy P, Pizer B: Meningeal melanocytoma. Childs Nerv Syst; 2006 Jun;22(6):556-61
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  • BACKGROUND: Meningeal melanocytoma was first described over 30 years ago as a benign tumour derived from melanocytes.
  • Although classified as a benign tumour, this tumour shows a marked tendency towards reduced survival following subtotal resection and transformation over time in a limited number to malignant melanoma.
  • Its classification as a benign tumour should be revised, given the published 5-year survival data.
  • [MeSH-minor] Case-Control Studies. Cerebral Angiography / methods. Child. Female. Humans. Immunohistochemistry / methods. Microscopy, Electron, Transmission / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16491422.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
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27. Amorim RL, Almeida AN, Aguiar PH, Fonoff ET, Itshak S, Fuentes D, Teixeira MJ: Cortical stimulation of language fields under local anesthesia: optimizing removal of brain lesions adjacent to speech areas. Arq Neuropsiquiatr; 2008 Sep;66(3A):534-8
MedlinePlus Health Information. consumer health - Brain Tumors.

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  • OBJECTIVE: The main objective when resecting benign brain lesions is to minimize risk of postoperative neurological deficits.
  • RESULTS: Lesions comprised 7 tumour lesions, 3 cavernomas and 1 dermoid cyst.
  • [MeSH-major] Brain Mapping / methods. Brain Neoplasms / surgery. Cerebral Cortex / surgery. Conscious Sedation / methods. Craniotomy / methods

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  • (PMID = 18813714.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Anesthetics, Local
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28. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46

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  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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29. Caldarelli C, Iacconi C, Della Giovampaola C, Iacconi P, Beatrice F: Vagal paragangliomas: two case reports. Acta Otorhinolaryngol Ital; 2007 Jun;27(3):139-43

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  • The first patient underwent surgery for suspected carotid body tumour.
  • Histological benign features, absence of neurological symptoms, of local invasion or intracranial extension confirm the frequent benign behaviour of these neoplasms.
  • [MeSH-minor] Cerebral Angiography. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • [Cites] Int J Oral Maxillofac Surg. 2002 Jun;31(3):334-6 [12190144.001]
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  • (PMID = 17883192.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2640040
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30. Sánchez-Legaza E, Meléndez Guerrero B, Sánchez Legaza B, Idelfonso Miranda J: [Acoustic neurinoma shown as a facial palsy]. An Otorrinolaringol Ibero Am; 2007;34(6):565-72
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  • [Transliterated title] Neurinoma del acústico manifestado como una parálisis facial.
  • Acoustic neurinoma is the most frequent benign tumour at the cerebellopontile angle.
  • It causes compressive type lesions in adjacent cerebral structures.

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  • (PMID = 18293776.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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31. Darwish B, Arbuckle S, Kellie S, Besser M, Chaseling R: Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. J Clin Neurosci; 2007 May;14(5):498-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Desmoplastic infantile ganglioglioma and astrocytoma (DIG/DIA) are rare intracranial tumours of early childhood that involve superficial cerebral cortex and leptomeninges.
  • Despite the large size of the tumour and the presence of poorly differentiated cells, it is believed that the prognosis of DIG/DIA is excellent.
  • It appears that not all tumours with histological features of DIG/DIA behave in a benign way.


32. Banka S, Walsh R, Brundler MA: First report of occurrence of choroid plexus papilloma and medulloblastoma in the same patient. Childs Nerv Syst; 2007 May;23(5):587-9
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  • INTRODUCTION: Choroid plexus papilloma is a benign epithelial brain tumour showing a striking predilection for infants and occurring most frequently in the lateral and fourth ventricles.
  • Medulloblastoma, on the other hand, is a primitive neuroectodermal tumour and is the most frequent malignant brain tumour of the posterior fossa in children.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Medulloblastoma / pathology. Papilloma, Choroid Plexus / pathology

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  • (PMID = 17106748.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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33. Karakas HM, Yakinci C, Firat AK, Kahraman B: Unilateral reverse ocular bobbing caused by tuberous sclerosis. Dev Med Child Neurol; 2006 Oct;48(10):851-4
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  • At birth, an upper left gingival mass, pathologically diagnosed as a benign granular cell tumour, was removed.
  • On computed tomography (CT), left middle cerebral pedincular and midpontine lesions were seen.

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  • (PMID = 16978467.001).
  • [ISSN] 0012-1622
  • [Journal-full-title] Developmental medicine and child neurology
  • [ISO-abbreviation] Dev Med Child Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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