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1. Fayed-Miguel N, Morales-Ramos H, Modrego-Pardo PJ: [Magnetic resonance imaging with spectroscopy, perfusion and cerebral diffusion in the diagnosis of brain tumours]. Rev Neurol; 2006 Jun 16-30;42(12):735-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Magnetic resonance imaging with spectroscopy, perfusion and cerebral diffusion in the diagnosis of brain tumours].
  • [Transliterated title] Resonancia magnética con espectroscopia, perfusión y difusión cerebral en el diagnóstico de los tumores cerebrales.
  • DEVELOPMENT AND CONCLUSIONS: Choline containing compounds using contralateral creatine and choline for normalization or ipsilateral N-acetyl-aspartate appeared to correlate best with the degree of tumor infiltration, regardless o tumor histological grade.
  • Magnetic resonance spectroscopy imaging (MRSI) seems more accurate than conventional magnetic resonance imaging (MRI) in defining indistinct tumor boundaries and quantifying the degree of tumor infiltration.
  • Angiogenesis, and increased vascular permeability, are characteristic of cerebral neoplasms; these processes can be imaged using perfusion MRI.
  • Most commonly, tumor perfusion is measured using rapid gradient T2-weighted imaging during bolus injection of gadolinium dimeglumine gadopentetate.
  • Cerebral blood volume increases with tumor grade, and maybe helpful in identifying tumor recurrence, and peri-tumoral edema, and distinguishing malignant from benign lesions.
  • [MeSH-minor] Aspartic Acid / analogs & derivatives. Aspartic Acid / metabolism. Biomarkers, Tumor / chemistry. Biomarkers, Tumor / metabolism. Blood-Brain Barrier / physiology. Brain Chemistry. Cerebrovascular Circulation. Choline / chemistry. Choline / metabolism. Contrast Media / metabolism. Image Processing, Computer-Assisted. Neoplasm Staging. Permeability. Prognosis

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  • (PMID = 16775800.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media; 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; N91BDP6H0X / Choline
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2. Rim NJ, Kim HS, Kim SY: A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery. Korean J Radiol; 2008 Jul;9 Suppl:S10-3
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  • [Title] A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery.
  • We present a case of sphenoid ridge meningotheliomatous meningioma manifesting as an SAH without pathologically atypical or malignant features, due to direct tumor invasion into the middle cerebral artery.
  • [MeSH-major] Meningeal Neoplasms / complications. Meningioma / complications. Middle Cerebral Artery / pathology. Skull Neoplasms / complications. Sphenoid Bone. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 18607117.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627185
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3. Scherer K, Johnston J, Panda M: Dural based mass: malignant or benign. J Radiol Case Rep; 2009;3(11):1-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dural based mass: malignant or benign.
  • Cerebral angiogram demonstrated a parafalcine mass supplied by the middle meningeal artery.
  • This paper additionally discusses the differentiation of benign dural based tumors like meningiomas from malignant findings.
  • Multiple adjunct studies can differentiate meningiomas from metastatic tumor.

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  • (PMID = 22470624.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303278
  • [Keywords] NOTNLM ; Dural based mass / meningioma / metastatic dural based lesions
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4. Zhang H, Rödiger LA, Shen T, Miao J, Oudkerk M: Perfusion MR imaging for differentiation of benign and malignant meningiomas. Neuroradiology; 2008 Jun;50(6):525-30
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  • [Title] Perfusion MR imaging for differentiation of benign and malignant meningiomas.
  • INTRODUCTION: Our purpose was to determine whether perfusion MR imaging can be used to differentiate benign and malignant meningiomas on the basis of the differences in perfusion of tumor parenchyma and/or peritumoral edema.
  • METHODS: A total of 33 patients with preoperative meningiomas (25 benign and 8 malignant) underwent conventional and dynamic susceptibility contrast perfusion MR imaging.
  • Maximal relative cerebral blood volume (rCBV) and the corresponding relative mean time to enhance (rMTE) (relative to the contralateral normal white matter) in both tumor parenchyma and peritumoral edema were measured.
  • The independent samples t-test was used to determine whether there was a statistically significant difference in the mean rCBV and rMTE ratios between benign and malignant meningiomas.
  • RESULTS: The mean maximal rCBV values of benign and malignant meningiomas were 7.16+/-4.08 (mean+/-SD) and 5.89+/-3.86, respectively, in the parenchyma, and 1.05+/-0.96 and 3.82+/-1.39, respectively, in the peritumoral edema.
  • The differences in rCBV and rMTE values between benign and malignant meningiomas were not statistically significant (P>0.05) in the parenchyma, but both were statistically significant (P<0.05) in the peritumoral edema.
  • Measurement of maximal rCBV and corresponding rMTE values in the peritumoral edema is useful in the preoperative differentiation between benign and malignant meningiomas.

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  • (PMID = 18379768.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2440923
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5. Landau D, Avgeropoulos N, Ma J: Cerebral amyloidoma mimicking intracranial tumor: a case report. J Med Case Rep; 2010;4:308

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral amyloidoma mimicking intracranial tumor: a case report.
  • INTRODUCTION: Cerebral amyloidoma is an infrequently recognized condition that can be confused with a more malignant etiology.
  • He was found to have a cerebral amyloidoma.
  • CONCLUSION: After discovery of the true etiology of his brain abnormality, it was determined that our patient had a more benign disease than was initially feared.
  • Cases such as this demonstrate why consideration of this disorder is important.

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  • (PMID = 20854655.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2946306
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6. Bilginer B, Söylemezoğlu F, Cila A, Akalan N: Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. Turk Neurosurg; 2009 Jan;19(1):69-72
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  • [Title] Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor.
  • Dysembryoplastic neuroepithelial tumor (DNT)- like lesions arise in extracortical locations and behave in a benign fashion similar to that of cortical DNTs.
  • A third ventricular mass lesion with disseminated spinal tumor was detected on his magnetic resonance imaging.
  • The presence of floating neurons in a mucinous matrix, oligodendrocyte-like cells (OLCs) aligning axonal columns and vessels, immunohistochemical profile of the neoplasm in addition to the clinical and radiological manifestations of the patient led to the diagnosis of "DNT-like neoplasm of the third ventricle".
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Magnetic Resonance Imaging. Neoplasms, Neuroepithelial / secondary. Spinal Neoplasms / secondary. Teratoma / secondary

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  • (PMID = 19263357.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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7. Pascual-Castroviejo I, Pascual-Pascual SI, Viaño J, Velázquez-Fragua R, Carceller-Benito F, Gutiérrez-Molina M, Morales-Bastos C: [Cerebral hemisphere tumours in neurofibromatosis type 1 during childhood]. Rev Neurol; 2010 Apr 16;50(8):453-7
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  • [Title] [Cerebral hemisphere tumours in neurofibromatosis type 1 during childhood].
  • AIM: To present seven tumors of the cerebral hemispheres in 6 children with neurofibromatosis type 1 (NF1).
  • PATIENTS AND METHODS: Six patients (three males and three females) of 600 cases of a series with NF1 showed features of cerebral hemispheres tumor (seizures, headache and hemiparesis).
  • Six patients had seven tumors (it was because one of them had one tumor in every frontal lobe, both with the same image characteristics), but they did not were removed and they were not studied histologically.
  • The histological study was made to the other five patients and showed that the histological nature corresponded to pilocytic astrocytoma in one patient, neuroepitelial dysembryoplastic tumor in one, polymorphe xanthoastrocytoma in one, neuroectodermic hamartoma in one, and inflammatory chronic non-granulomatose lesion in one.
  • CONCLUSION: The prevalence of the tumors in the cerebral hemispheres is very low (1%) in the patients with NF1.
  • The tumors commonly are histologically benign, and they can be found in peripheral or deep region of the cerebral hemispheres.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Cortex / pathology. Neurofibromatosis 1 / pathology


8. Widdel L, Kleinschmidt-DeMasters BK, Kindt G: Tumor-to-tumor metastasis from hematopoietic neoplasms to meningiomas: report of two patients with significant cerebral edema. World Neurosurg; 2010 Jul;74(1):165-71
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  • [Title] Tumor-to-tumor metastasis from hematopoietic neoplasms to meningiomas: report of two patients with significant cerebral edema.
  • BACKGROUND: Tumor-to-tumor metastasis is a rare, but well-reported, curiosity in which one type of primary neoplasm metastasizes to another primary tumor type within the same person.
  • OBJECTIVE: To report two examples of benign meningiomas in which metastatic tumor deposits from the patient's hematopoietic neoplasm to the meningioma caused significant peritumoral edema, necessitating semiemergent surgical resection.
  • RESULTS: One patient had multiple myeloma associated with extensive necrosis within his otherwise benign convexity meningioma; first diagnosis of his IgG, kappa-restricted plasma cell dyscrasia was made from this tumor-to-tumor meningioma specimen.
  • Dural marginal zone lymphoma was identified within epidural, intradural, and subdural spaces, in the same location as an underlying benign meningioma.
  • CONCLUSIONS: Although rare, neurosurgeons should be aware of the entity of tumor-to-tumor metastasis as, in large series, meningiomas are the third most frequent recipient tumor type and pituitary adenomas, the fifth most frequent, probably reflecting their rich vascularity.
  • In examples where the donor tumor type is a hematopoietic neoplasm, significant edema can be produced by the tumor-to-tumor metastasis.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21300009.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Ortega-Martínez M, Cabezudo-Artero JM, Fernández-Portales I, Pimentel JJ, Gómez de Tejada R: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien); 2007 Dec;149(12):1229-36; discussion 1236-7
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  • [Title] Diffuse leptomeningeal seeding from benign choroid plexus papilloma.
  • Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional.
  • Neither the initial tumour nor the recurrence showed malignant histological features.
  • We review the literature concerning leptomeningeal dissemination of benign choroid plexus papillomas.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Fourth Ventricle / surgery. Meningeal Neoplasms / secondary. Neoplasm Seeding. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Disease Progression. Fatal Outcome. Female. Humans. Ki-67 Antigen / analysis. Laminectomy. Magnetic Resonance Imaging. Meninges / pathology. Reoperation. S100 Proteins / analysis

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  • (PMID = 17924056.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
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10. Ideguchi M, Kajiwara K, Yoshikawa K, Kato S, Fujii M, Fujisawa H, Suzuki M: Benign fibrous histiocytoma of the skull with increased intracranial pressure caused by cerebral venous sinus occlusion. J Neurosurg; 2009 Sep;111(3):504-8

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  • [Title] Benign fibrous histiocytoma of the skull with increased intracranial pressure caused by cerebral venous sinus occlusion.
  • The authors present a very rare case of benign fibrous histiocytoma of the skull with increased intracranial pressure caused by sinus occlusion.
  • Imaging findings showed that the skull tumor was located at the right occipital bone with bone disruption and a compressed right sigmoid sinus.
  • Immunohistochemical analysis showed that the tumor was positive for CD68, alpha1-antichymotrypsin, and alpha1-antitrypsin.
  • From these findings, the tumor was diagnosed as a primary benign fibrous histiocytoma of the skull.
  • [MeSH-major] Cranial Sinuses. Histiocytoma, Benign Fibrous / physiopathology. Intracranial Pressure. Skull Neoplasms / physiopathology

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  • (PMID = 19249956.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Ng WH, Cheong DL, Khu KJ, Venkatesh G, Ng YK, Lim CC: Diffusion tensor tractography: corticospinal tract fiber reduction is associated with temporary hemiparesis in benign extracerebral lesions. Neurosurgery; 2008 Sep;63(3):452-8; discussion 458-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion tensor tractography: corticospinal tract fiber reduction is associated with temporary hemiparesis in benign extracerebral lesions.
  • OBJECTIVE: Benign extracerebral lesions such as meningiomas may cause hemiparesis by compression and deviation without infiltrating the white matter.
  • We used magnetic resonance diffusion tensor imaging and diffusion tensor tractography to investigate the effects of benign extracerebral lesions on the corticospinal tract (CST).
  • METHODS: Thirteen patients with extracerebral lesions (11 benign meningiomas and 2 benign cysts) underwent magnetic resonance diffusion tensor imaging and diffusion tensor tractography of the CST using fiber assignment by continuous tractography.
  • The tumor volume, relative fractional anisotropy, fiber deviation, relative fiber number, and relative fiber per voxel were compared between patients without and with temporary presurgical hemiparesis.
  • There was no significant difference in the tumor volume, relative fractional anisotropy, presence of cerebral edema, or CST deviation between groups.
  • CONCLUSION: In patients with benign extracerebral lesions, reduction in fiber number and fiber per voxel, but not fiber deviation, correlated with temporary hemiparesis.
  • Clinical recovery was possible even if the CST fibers detected by diffusion tensor tractography were reduced by benign extracerebral lesions.

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  • (PMID = 18812956.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Asioli S, Senetta R, Maldi E, D'Ambrosio E, Satolli MA, Bussolati G, Cassoni P: "Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung. Virchows Arch; 2007 May;450(5):591-4
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  • [Title] "Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung.
  • Lung "metastases" of benign meningiomas are rarely described events of biological and clinical interest.
  • Anamnesis revealed that the patient underwent a surgical resection of cerebral meningioma 12 years before.
  • The morphological and immunohistochemical features of this lesion, together with the similarity with the original cerebral tumour and its indolent evolution, led to a final diagnosis of "benign" meningioma metastatic to the lung.
  • They represent a typical example of "benign" tumours that may implant to the lung similar to other tumours, definitely considered benign but reported to rarely present unusual secondary localization.
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Neoplasm Metastasis / pathology. Tomography, X-Ray Computed

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  • (PMID = 17431673.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Mahore A, Chagla A, Goel A: Seeding metastases of a benign intraventricular meningioma along the surgical track. J Clin Neurosci; 2010 Feb;17(2):253-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seeding metastases of a benign intraventricular meningioma along the surgical track.
  • Seeding metastases of a benign intraventricular meningioma along the surgical track is rare.
  • We report a patient with a benign fibroblastic intraventricular meningioma that had spread along the path of previous surgery; the recurrences as well as the primary tumor were benign.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Lateral Ventricles / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Metastasis / pathology. Neoplasm Seeding
  • [MeSH-minor] Contrast Media. Headache / etiology. Humans. Iatrogenic Disease / prevention & control. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Radiotherapy. Treatment Outcome. Ventriculostomy / adverse effects. Ventriculostomy / methods. Vomiting / etiology

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20036547.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Contrast Media
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14. Bledsoe JM, Link MJ, Stafford SL, Park PJ, Pollock BE: Radiosurgery for large-volume (&gt; 10 cm3) benign meningiomas. J Neurosurg; 2010 May;112(5):951-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for large-volume (> 10 cm3) benign meningiomas.
  • The average tumor volume was 17.5 cm3 (range 10.1-48.6 cm3); the average tumor margin dose was 15.1 Gy (range 12-18 Gy); and the mean follow-up duration was 70.1 months (range 12-199 months).
  • RESULTS: Tumor control was 99% at 3 years and 92% at 7 years after radiosurgery.
  • Thirty complications after radiosurgery were noted in 27 patients (23%), including 7 cases of seizures, 6 cases of hemiparesis, 5 cases of trigeminal injury, 4 cases of headaches, 3 cases of diplopia, 2 cases each of cerebral infarction and ataxia, and 1 case of hearing loss.
  • CONCLUSIONS: The morbidity associated with SRS for patients with benign meningiomas > 10 cm(3) is greater for supratentorial tumors compared with skull base tumors.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ataxia / epidemiology. Ataxia / etiology. Cerebral Infarction / epidemiology. Cerebral Infarction / etiology. Female. Follow-Up Studies. Headache / epidemiology. Headache / etiology. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / surgery. Young Adult

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  • [CommentIn] J Neurosurg. 2010 Dec;113(6):1335-6; author reply 1336-7 [20887089.001]
  • (PMID = 19764829.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Davidson L, Fishback D, Russin JJ, Weiss MH, Yu C, Pagnini PG, Zelman V, Apuzzo ML, Giannotta SL: Postoperative Gamma Knife surgery for benign meningiomas of the cranial base. Neurosurg Focus; 2007;23(4):E6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative Gamma Knife surgery for benign meningiomas of the cranial base.
  • The authors analyzed the mid- and long-term results obtained in patients treated with postresection Gamma Knife surgery (GKS) for residual or recurrent benign meningiomas of the cranial base.
  • METHODS: Thirty-six patients with residual or recurrent benign meningiomas of the skull base following one or more surgical procedures underwent GKS.
  • The median tumor volume was 4.1 ml (range 0.8-20 ml) and the median radiation dose to the tumor margin was 16 Gy (range 15-16 Gy).
  • One patient suffered transient cerebral edema 6 months after GKS.
  • Based on imaging documentation, a partial response was seen in five patients (13.9%), the disease remained stable in 30 patients (83.3%), and in one patient (2.8%) there was an increase in tumor size.
  • CONCLUSIONS: Gamma Knife surgery was shown to be an excellent adjunct to resection because of its durable rate of tumor control and low toxicity.

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  • (PMID = 17961043.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Kawaguchi T, Kumabe T, Shimizu H, Watanabe M, Tominaga T: 201Tl-SPECT and 1H-MRS study of benign lateral ventricle tumors: differential diagnosis of subependymoma. Neurosurg Rev; 2005 Apr;28(2):96-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 201Tl-SPECT and 1H-MRS study of benign lateral ventricle tumors: differential diagnosis of subependymoma.
  • Our study includes nine cases of benign lateral ventricle tumors including two cases of central neurocytoma, two of subependymal giant cell astrocytoma, two of pilocytic astrocytoma and three of subependymoma treated surgically between 1996 and 2003.
  • All three types of tumor demonstrated heterogeneous enhancement on MR imaging with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and increased choline (Cho) peak and decreased N-acetyl aspartate (NAA) and creatine (Cre) peaks on (1)H-MRS. (201)Tl-SPECT showed high uptake of (201)Tl without wash out in all cases of central neurocytoma, subependymal giant cell astrocytoma and pilocytic astrocytoma, but no uptake in cases of subependymoma.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebral Ventricle Neoplasms / diagnosis. Glioma, Subependymal / diagnosis. Lateral Ventricles. Neurocytoma / diagnosis

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  • (PMID = 15580370.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Thallium Radioisotopes
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17. Balamurali G, du Plessis DG, Wengoy M, Bryan N, Herwadkar A, Richardson PL: Thorotrast-induced primary cerebral angiosarcoma: case report. Neurosurgery; 2009 Jul;65(1):E210-1; discussion E211
Hazardous Substances Data Bank. THORIUM DIOXIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thorotrast-induced primary cerebral angiosarcoma: case report.
  • OBJECTIVE: Thorotrast was used as a contrast medium in clinical practice until the 1960s for outlining cerebral abscess cavities and ventricular cavities, and for angiography.
  • CLINICAL PRESENTATION: The patient presented with a progressive left-sided weakness 62 years after initial surgery for a right parietal cerebral abscess, which included the instillation of Thorotrast into the abscess cavity.
  • Computed tomography showed a right parietal tumor.
  • INTERVENTION: An explorative craniotomy showed an intrinsic, infiltrating, very vascular tumor with surrounding calcification.
  • The tumor appeared to arise from a benign cavernous vasoformative lesion intimately associated with a Thorotrast-type granuloma.
  • CONCLUSION: The histology, confirmation of radioactivity of the material obtained from within the tumor, and latency period of presentation provide compelling support for tumor induction by the Thorotrast.
  • Primary lesions of the central nervous system associated with Thorotrast are very rarely reported, despite its extensive use in cerebral angiography and management of brain abscess between 1930 and 1960.
  • [MeSH-minor] Aged. Cerebral Angiography. Cerebral Cortex / pathology. Cerebral Cortex / surgery. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19574803.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 9XA7X17UQC / Thorium Dioxide
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18. Sura P, Srebro Z: Cerebral pathology in immunodeficient gnotobiotic laboratory mice. Folia Biol (Krakow); 2005;53(3-4):205-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral pathology in immunodeficient gnotobiotic laboratory mice.
  • Gnotobiotic autoimmunity prone, antigen presentation, T lymphocyte receptor gene knockout mice show cerebral pathology in the form of meningitis, venous blood statis with subarachnoid hemorrhages and massive hemosiderin deposits.
  • Only in the latter strain was a strong pineal hypertrophy in the form of a benign tumor present in ca.
  • [MeSH-major] Cerebrum / pathology

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  • (PMID = 19058545.001).
  • [ISSN] 0015-5497
  • [Journal-full-title] Folia biologica
  • [ISO-abbreviation] Folia Biol. (Krakow)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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19. Berne JP, Bouchot O, Jazayeri S, Tatou E, Gomez-Bielfeld MC, Martin L, Brenot R, David M: [Cardiac papillary fibroelastoma, a rare valvular source of cerebral embolism: report of two cases]. Ann Cardiol Angeiol (Paris); 2009 Feb;58(1):61-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac papillary fibroelastoma, a rare valvular source of cerebral embolism: report of two cases].
  • Cardiac papillary fibroelastomas are very rare and benign tumors, usually involving heart valves.
  • The only curative treatment consists of the excision of the tumor under cardiopulmonary bypass.
  • We report the cases of two patients suffering from acute cerebral embolism.

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  • (PMID = 18980749.001).
  • [ISSN] 1768-3181
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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20. Mizuguchi M: Abnormal giant cells in the cerebral lesions of tuberous sclerosis complex. Congenit Anom (Kyoto); 2007 Mar;47(1):2-8
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  • [Title] Abnormal giant cells in the cerebral lesions of tuberous sclerosis complex.
  • Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations of either of the two tumor suppressor genes, TSC1 and TSC2, encoding hamartin and tuberin, respectively.
  • TSC is pathologically characterized by the occurrence of multiple hamartias (focal dysplasias) and hamartomas (benign tumors) in the brain and many other organs.
  • Cortical tubers are hamartias in the cerebral cortex responsible for many neuropsychiatric symptoms of TSC.
  • [MeSH-major] Cerebral Cortex / pathology. Giant Cells / pathology. Tuberous Sclerosis / pathology
  • [MeSH-minor] Animals. Cell Differentiation. Cell Size. Genes, Tumor Suppressor. Hamartoma / pathology. Humans. Models, Animal. Models, Biological

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  • (PMID = 17300684.001).
  • [ISSN] 0914-3505
  • [Journal-full-title] Congenital anomalies
  • [ISO-abbreviation] Congenit Anom (Kyoto)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Number-of-references] 67
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21. Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol; 2007 May;83(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature.
  • Cerebrospinal metastases of benign choroid plexus papillomas (CPPs) are extremely rare.
  • Plain CT scan of the cranium revealed a partly calcified tumor filling the fourth ventricle and its right recess.
  • Cranial MRI showed an inhomogeneously contrast-enhancing tumor and leptomeningeal enhancement encasing the brain stem.
  • Complete resection of the tumor was carried out, and seedings to the floor of the fourth ventricle and cervico-medullary junction were found during the operation.
  • While intraoperative frozen section suggested pathology of papillary ependymoma or CPP, to our surprise, final histological examination revealed a benign choroid plexus papilloma.
  • This special case helps increase our understanding of benign CPPs and expands our differential diagnostic consideration of lesions with similar manifestations.
  • [MeSH-major] Central Nervous System Neoplasms / secondary. Cerebral Ventricle Neoplasms / secondary. Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / secondary. Fourth Ventricle. Papilloma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Seeding. Neurosurgical Procedures / adverse effects. Subarachnoid Space. Tomography, X-Ray Computed

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  • (PMID = 17387433.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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22. Thielke D, Thyssen JP, Sejersen HM: [Cardiac myxoma--a rare cause of cerebral embolism]. Ugeskr Laeger; 2008 Aug 11;170(33):2460
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  • [Title] [Cardiac myxoma--a rare cause of cerebral embolism].
  • Cardiac myxoma is the most common benign heart tumor.
  • We report a case with multiple brain metastases, presumably due to tumor embolization.
  • Though myxoma is a rare cause of cerebral embolism, detection of this tumor is relatively easy and surgical resection of myxoma is usually a permanent measure to prevent subsequent stroke.

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  • (PMID = 18761832.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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23. Kawahara I, Nakamoto M, Matsuo Y, Tokunaga Y: [Subclavian steal phenomenon associated with hypervascular thyroid tumor]. No Shinkei Geka; 2010 May;38(5):473-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Subclavian steal phenomenon associated with hypervascular thyroid tumor].
  • The patient was hospitalized with acute cerebral infarction due to middle cerebral artery (MCA) severe stenosis.
  • Thyroid tumor was regarded as benign by radiological findings, laboratory data, and physical examination.
  • If SSS becomes symptomatic, removal of the thyroid tumor may be indicated.
  • [MeSH-minor] Aged. Cerebral Angiography. Female. Humans

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  • (PMID = 20522919.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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24. Prayson RA: Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. Ann Diagn Pathol; 2009 Feb;13(1):36-40
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  • [Title] Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation.
  • Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon.
  • This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation occurring in a 48-year-old woman.
  • These cells were arranged against a benign lipomatous background.
  • The glioblastomatous component of the tumor demonstrated glial fibrillary acidic protein immunoreactivity.

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  • (PMID = 19118780.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Synaptophysin
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25. Uro-Coste E, Ssi-Yan-Kai G, Guilbeau-Frugier C, Boetto S, Bertozzi AI, Sevely A, Lolmede K, Delisle MB: Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation. J Neurooncol; 2010 May;98(1):143-9
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  • [Title] Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation.
  • Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are rare intracranial tumors that mostly occur in the first 2 years of life and involve superficial cerebral cortex.
  • Magnetic resonance imaging showed a temporal tumor with prepontine and interpeduncular extension, and two other distinct localizations in cisterna magna and left cerebellar hemisphere.
  • When the tumor is large, multilobular involvement is common, but multiple location of DIG is, on the contrary, very rare.

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  • (PMID = 20012157.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Fulkerson DH, Horner TG, Hattab EM: Histologically benign intraventricular meningioma with concurrent pulmonary metastasis: case report and review of the literature. Clin Neurol Neurosurg; 2008 Apr;110(4):416-9
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  • [Title] Histologically benign intraventricular meningioma with concurrent pulmonary metastasis: case report and review of the literature.
  • Metastasis from a histologically "benign" meningioma is a rare, but well-documented event.
  • In this report, the authors present a rare case of the concurrent presentation of a histologically benign intraventricular meningioma and a solitary lung lesion which proved to be metastatic meningioma.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Meningeal Neoplasms / pathology. Meningioma / secondary. Tomography, X-Ray Computed
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy, Needle. Humans. Ki-67 Antigen / analysis. Lung / pathology. Male. Middle Aged. Mitotic Index. Mucin-1 / analysis. Receptors, Progesterone / analysis

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  • (PMID = 18282656.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Receptors, Progesterone
  • [Number-of-references] 32
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27. Sawada K, Maehara T, Inaji M, Toriyama H, Okada T, Nariai T, Aoyagi M, Doi M, Ohno K: [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism]. No Shinkei Geka; 2010 Apr;38(4):347-51
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  • [Title] [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism].
  • Primary aldosteronism (PA) has been recognized as a relatively benign form of hypertension associated with a low incidence of vascular complications.
  • Cerebral angiography showed multiple small aneurysms.
  • The initial intervention was aneurysm clipping for a ruptured aneurysm at the bifurcation of the right middle cerebral artery.
  • She was diagnosed with PA on the basis of elevated plasma aldosterone, suppressed plasma rennin, and a right adrenal tumor detected by abdominal CT scanning.

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  • (PMID = 20387576.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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28. Mori Y, Kondo T, Iwakoshi T, Kida Y, Kobayashi T, Yoshimoto M, Hasegawa T: Malignant lymphoma arising in the cerebral parenchyma adjacent to a parasagittal meningioma. Neurol Med Chir (Tokyo); 2006 Aug;46(8):398-400
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  • [Title] Malignant lymphoma arising in the cerebral parenchyma adjacent to a parasagittal meningioma.
  • Magnetic resonance (MR) imaging disclosed a newly developed well-enhanced area in the cerebral parenchyma adjacent to the stable original meningioma.
  • The extra-axial tumor was identified as benign transitional meningioma and the intra-axial tumor as diffuse large cell type malignant lymphoma.

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  • (PMID = 16936461.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Wang F, Qiao G, Li X, Gui Q: A dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus in a 57-year-old woman: case report. Neurosurgery; 2007 Aug;61(2):E420; discussion E420
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  • [Title] A dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus in a 57-year-old woman: case report.
  • DNTs may also arise outside of the cerebral cortex.
  • During a 7-year follow-up period, the tumor did not recur.
  • CONCLUSION: Unlike diffuse gliomas, such as oligodendrogliomas and central neurocytomas, DNTs are benign lesions with a favorable prognosis after surgical resection.

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  • (PMID = 17762726.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Li NY, Zhou XJ, Jin XZ, Meng K, Ma HH, Zheng XG, Jiang SJ, Sun GQ: [A clinicopathologic study of dysembryoplstic neuroepithelial tumor]. Zhonghua Bing Li Xue Za Zhi; 2005 Sep;34(9):561-5
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  • [Title] [A clinicopathologic study of dysembryoplstic neuroepithelial tumor].
  • OBJECTIVE To study the clinicopathologic features, radiologic findings, treatment modalities and prognosis of dysembryoplastic neuroepithelial tumor (DNT).
  • On magnetic resonance imaging (MRI) study, the tumor was hypodense on T1 and hyperdense on T2.
  • None of the cases showed tumor recurrence after operation.
  • The tumor was formed by an admixture of oligodendrocyte-like cells, mature neurons and astrocytes, with obvious microcystic changes.
  • CONCLUSIONS: DNT is a benign tumor (corresponding to WHO grade I) that can be cured by surgical excision, despite sometimes incomplete tumor removal.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Cortex / pathology. Neoplasms, Neuroepithelial / pathology. Oligodendroglia / pathology

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  • (PMID = 16468305.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Synaptophysin
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31. Zhou Y, Liu F, Xu Q, Wang X: Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy. J Exp Clin Cancer Res; 2010;29:138
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy.
  • The aim of this study was to examine the expression profile of DKK-1 gene in human glioma and its association with tumor malignancy.
  • A total of 47 tumor biopsy specimens and 11 normal brain tissue samples from patients with cerebral trauma internal decompression were embedded in paraffin blocks and used for immunostaining.
  • We further examined serologic concentrations and cerebral fluid levels of DKK-1 in patients with tumors.
  • RESULTS: DKK-1 could only be detected in 12 human glioblastoma cell lines, not in a panel of other tumor and normal cell lines.
  • Kendall's tau-c association analysis also revealed the increased DKK-1 protein expression in tumor tissues of higher pathologic classification.
  • The levels of cerebral fluid DKK-1 protein were significantly higher in glioma patients than in healthy donors or in neuronal benign tumor patients, suggesting that the DKK-1 molecule in cerebral fluids can be applicable to detect the presence of glioma and be developed as a novel prognostic treatment.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / genetics. Gene Expression Profiling. Glioma / genetics. Intercellular Signaling Peptides and Proteins / metabolism

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  • (PMID = 21029453.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DKK1 protein, human; 0 / Intercellular Signaling Peptides and Proteins
  • [Other-IDs] NLM/ PMC2990739
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32. Saint-Blancard P, Goasguen O, Kossowski M, Dulou R: [A rare primary tumor of the cerebellopontine angle: melanotic schwannoma, a pigmented tumor with unpredictable prognosis]. Rev Med Interne; 2008 Jul;29(7):587-90
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  • [Title] [A rare primary tumor of the cerebellopontine angle: melanotic schwannoma, a pigmented tumor with unpredictable prognosis].
  • Schwannomas are common ubiquitous benign tumours of the nervous sheaths.
  • We report a case of melanotic schwannoma of the cerebellopontine angle in a 52-year-old man with a slowly progressive cerebellar syndrome since 1978, who presented with a posterior cerebral fossa bleeding.

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  • (PMID = 18276040.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Melanins
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33. Josan V, Smith P, Kornberg A, Rickert C, Maixner W: Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case report. J Neurosurg; 2007 Jun;106(6 Suppl):509-12
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  • [Title] Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case report.
  • Dysembryoplastic neuroepithelial tumors (DNETs) are benign supratentorial tumors based in the cerebral cortex.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cerebral Cortex. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis


34. Javahery RJ, Davidson L, Fangusaro J, Finlay JL, Gonzalez-Gomez I, McComb JG: Aggressive variant of a papillary glioneuronal tumor. Report of 2 cases. J Neurosurg Pediatr; 2009 Jan;3(1):46-52
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  • [Title] Aggressive variant of a papillary glioneuronal tumor. Report of 2 cases.
  • Papillary glioneuronal tumors are a newly recognized type of brain neoplasm characterized by prominent pseudopapillary structures and glioneuronal elements.
  • The authors present 2 patients with an aggressive variant of the tumor.
  • The first patient had dissemination of her tumor and the second had local spreading.
  • Therefore, the authors conclude that papillary glioneuronal tumors do not always behave in a strictly benign fashion.
  • [MeSH-major] Brain Neoplasms / surgery. Carcinoma, Papillary / surgery. Cerebral Cortex / surgery. Frontal Lobe / surgery. Ganglioglioma / surgery. Neoplasm Recurrence, Local / surgery. Neoplasms, Complex and Mixed / surgery. Neoplasms, Multiple Primary / surgery

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  • (PMID = 19119904.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Vimentin
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35. Arai A, Sasayama T, Tamaki M, Sakagami Y, Enoki E, Ohbayashi C, Kohmura E: Rosette-forming glioneuronal tumor of the fourth ventricle--case report. Neurol Med Chir (Tokyo); 2010;50(3):224-8

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  • [Title] Rosette-forming glioneuronal tumor of the fourth ventricle--case report.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare tumor included as a novel glioneuronal neoplasm in the 2007 World Health Organization classification of brain tumors.
  • The tumor was gross totally resected.
  • The prognosis is benign, but relatively aggressive behaviors such as tumor growth, recurrence, and acute deterioration due to intratumoral hemorrhaging can occur.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Infratentorial Neoplasms / pathology. Neoplasms, Neuroepithelial / pathology. Teratoma / pathology

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  • (PMID = 20339273.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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36. Kinfe TM, Tschan CA, Stan AC, Krauss JK: Solitary fibrous tumor of the foramen of Monro. Clin Neurol Neurosurg; 2008 Apr;110(4):404-7

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  • [Title] Solitary fibrous tumor of the foramen of Monro.
  • This benign entity shows histoimmunochemically strong positivity for vimentin and calretinin.
  • Imaging studies demonstrated a tumor at the foramen of Monro which was thought to be a colloid cyst and she underwent CSF shunting.
  • After recurrent episodes of shunt dysfunction the tumor was removed via a transventricular approach guided by endoscopic ventriculoscopy.
  • The histopathological examination revealed a solitary fibrous tumor.
  • This is the first report on a solitary fibrous tumor located at the foramen of Monro in an elderly patient.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Cerebral Ventricles / surgery. Solitary Fibrous Tumors / surgery

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  • (PMID = 18243526.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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37. Koçak H, Ozyazicioğlu A, Gündoğdu C, Sevimli S: Cardiac hemangioma complicated with cerebral and coronary embolization. Heart Vessels; 2005 Nov;20(6):296-7
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  • [Title] Cardiac hemangioma complicated with cerebral and coronary embolization.
  • Cardiac hemangiomas are rare, benign vascular tumors of the heart.
  • Histopathological examination revealed that the tumor was a hemangioma.

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  • (PMID = 16314913.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL: Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case. Neuropathology; 2009 Oct;29(5):574-8
MedlinePlus Health Information. consumer health - Brain Tumors.

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  • [Title] Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
  • Cerebral and spinal location of glioneuronal tumors have been recently described as a novel type of primary CNS neoplasia.
  • A distinctive rare form of glioneuronal tumors with neuropil-like islands (GTNI) have been reported to occur in the adult cerebrum, whereas spinal GTNI localization is extremely rare.
  • Histologically the tumor was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers.
  • Cerebral GTNI shows abundant glial components not rarely exhibiting anaplastic features that justify their inclusion within the group of diffuse astrocytomas.
  • Nevertheless, due to their exceptional rarity, the natural history of these lesions is not yet fully understood, but spinal GTNI seems to have an unfavorable clinical course despite their benign histopathological features, which must be taken into account for appropriate treatment and follow-up of the patient.

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  • (PMID = 19077041.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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39. Nagesh V, Tsien CI, Chenevert TL, Ross BD, Lawrence TS, Junick L, Cao Y: Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study. Int J Radiat Oncol Biol Phys; 2008 Mar 15;70(4):1002-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study.
  • PURPOSE: To quantify the radiation-induced changes in normal-appearing white matter before, during, and after radiotherapy (RT) in cerebral tumor patients.
  • METHODS AND MATERIALS: Twenty-five patients with low-grade glioma, high-grade glioma, or benign tumor treated with RT were studied using diffusion tensor magnetic resonance imaging.

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  • (PMID = 18313524.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA113699-02; United States / NCI NIH HHS / CA / R21 CA113699; United States / NCI NIH HHS / CA / R21 CA113699-02; United States / NCI NIH HHS / CA / P01 CA059827; United States / NCI NIH HHS / CA / 3P01 CA59827; United States / NCI NIH HHS / CA / CA059827-06A1; United States / NCI NIH HHS / CA / P01 CA085878-01A2; United States / NCI NIH HHS / CA / P02 CA85878; United States / NCI NIH HHS / CA / P01 CA059827-06A1; United States / NCI NIH HHS / CA / P01 CA085878; United States / NCI NIH HHS / CA / R21 CA11369901
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS42273; NLM/ PMC2376211
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40. Pui MH, Wang Y: Diffusion and magnetization transfer MRI of brain infarct, infection, and tumor in children. Clin Imaging; 2005 May-Jun;29(3):162-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion and magnetization transfer MRI of brain infarct, infection, and tumor in children.
  • The purpose of this study was to determine the efficacy of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) in the differential diagnosis of brain infarct, infection, hamartoma, and tumor in 106 children.
  • There was an inverse relationship between ADC and MTR in subacute/chronic infarct, infection, hamartoma, arachnoid cyst, and tumor relative to normal brain parenchyma.
  • DWI and MTI had a complementary role in the differential diagnosis of acute infarct from infection with lower MTR, from hamartoma with higher ADC, and from low-grade gliomas and benign tumors that had higher ADCs and lower MTRs.
  • ADCs increased and MTRs decreased with the duration of infarct and lower tumor grade.
  • [MeSH-major] Brain / pathology. Brain Neoplasms / diagnosis. Central Nervous System Infections / diagnosis. Cerebral Infarction / diagnosis. Diffusion Magnetic Resonance Imaging. Image Processing, Computer-Assisted

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  • (PMID = 15855060.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Tsutsumi S, Abe Y, Yasumoto Y, Shiono S, Ito M: Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome. Neurol Med Chir (Tokyo); 2010;50(6):499-502
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  • [Title] Metastatic skull base tumor from thymic carcinoma mimicking Tolosa-Hunt syndrome.
  • Magnetic resonance imaging confirmed a broad-based, intensely enhanced extraaxial tumor of 4x4x4 cm diameter with dural tail sign.
  • Cerebral angiography demonstrated insignificant blood supply both from the internal carotid and middle meningeal arteries.
  • Nearly total tumor resection was achieved via orbitofrontotemporal craniotomy.
  • Intraoperative findings revealed the extraaxial tumor with broad attachment to the dura mater and invasion to the optic and oculomotor nerves.
  • Histological examination revealed hypercellular tumor with significant cell atypism, mitotic activity, and focal necrosis.
  • Systemic examination performed postoperatively revealed a thymic tumor without additional remote lesions.
  • The final diagnosis was metastatic brain tumor from thymic carcinoma.
  • Rapid progression of neurological impairment inconsistent with a benign extraaxial tumor needs prompt surgical intervention.

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  • (PMID = 20587979.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Luan S, Zhuang D, Sun L, Huang FP: Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: Case report and review of literature. Clin Neurol Neurosurg; 2010 May;112(4):362-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: Case report and review of literature.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been identified as a novel and distinctive type of primary central nervous system neoplasm.
  • RGNT of the fourth ventricle is a rare, benign tumor with an excellent prognosis.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Glioma / pathology. Rosette Formation

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  • [Copyright] Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20133047.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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43. Caballero PE: Left atrial sarcoma presenting as cerebral infarction. Neurologist; 2008 Mar;14(2):131-3
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  • [Title] Left atrial sarcoma presenting as cerebral infarction.
  • OBJECTIVE: Primary heart tumors are rare and most of them are benign.
  • The majority of benign cardiac tumors are myxomas, although almost all malignant cardiac tumors are sarcomas.
  • METHODS: There have been cases described of stroke secondary to embolism caused by cardiac sarcomas, but it is rarely the first manifestation of the tumor.
  • [MeSH-major] Cerebral Infarction / etiology. Heart Neoplasms / complications. Intracranial Embolism / etiology. Sarcoma / complications

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  • (PMID = 18332844.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Messing-Jünger AM, Riemenschneider MJ, Reifenberger G: A 21-year-old female with a third ventricular tumor. Brain Pathol; 2006 Jan;16(1):87-8, 93

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  • [Title] A 21-year-old female with a third ventricular tumor.
  • Intraoperatively, the tumor showed a close relationship to the choroid plexus of the third ventricle.
  • Histopathology revealed a benign schwannoma of World Health Organization grade I.
  • Most of these tumors were benign schwannomas, except for 2 cases of malignant peripheral nerve sheath tumors.
  • The tumor of our patient is the first reported schwannoma of the third ventricle.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurilemmoma / pathology. Neurilemmoma / surgery

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  • (PMID = 16612987.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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45. Wang L, Fan M, Ju W, Pang ZL, Zhu ZH, Li B, Xiao YJ, Zeng FQ, Xiao CG: [Endourological treatment of aged high-risk patients with benign prostate hyperplasia: a report of 283 cases]. Zhonghua Nan Ke Xue; 2010 Sep;16(9):803-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endourological treatment of aged high-risk patients with benign prostate hyperplasia: a report of 283 cases].
  • OBJECTIVE: To evaluate the safety and effectiveness of endourological techniques in the treatment of benign prostate hyperplasia (BPH) in aged high-risk patients.
  • METHODS: We used endourological techniques in the treatment of 283 BPH patients aged over 70 years and complicated with hydronephrosis, renal failure, heart failure, cerebral infarction, respiratory dysfunction, anemia, diabetes, bladder tumor, or prostate weight over 80 g, TURP (transurethral resection of the prostate) for 112 cases and PKRP (transurethral plasmakinetic resection of the prostate) for the other 171.

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  • (PMID = 21171264.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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46. Marhold F, Preusser M, Dietrich W, Prayer D, Czech T: Clinicoradiological features of rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: report of four cases and literature review. J Neurooncol; 2008 Dec;90(3):301-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicoradiological features of rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: report of four cases and literature review.
  • BACKGROUND: Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a recently characterized rare tumor entity.
  • Despite benign histological features and a reported favorable postoperative course, there is still limited clinical experience with this tumor.
  • RESULTS: Patient 1 presented on an emergency basis due to intratumoral hemorrhage and tumor enlargement followed by life-threatening obstructive hydrocephalus.
  • CONCLUSIONS: The spectrum of presenting symptoms of RGNT is wide, nonspecific, and typically depends on tumor size and extent.
  • This tumor entity should be considered in the differential diagnosis of posterior fossa masses in order to avoid undue surgical aggressiveness.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / radiography. Fourth Ventricle / radiography. Ganglioglioma / pathology. Ganglioglioma / radiography

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  • (PMID = 18777116.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
  • [Number-of-references] 14
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47. Koch HJ, Roeber S, Zimmermann UW, Schäfer C, Villarrubia V, Kuchelmeister K, Schachenmayr W, Bogdahn U, Steinbrecher A: [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]. Wien Med Wochenschr; 2005 Aug;155(15-16):360-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].
  • Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes.
  • Meningeal spread of this tumour is very rarely observed.
  • This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse.
  • [MeSH-major] Cerebellopontine Angle. Melanocytes / pathology. Melanoma. Meningeal Neoplasms. Meninges. Neoplasm Seeding
  • [MeSH-minor] Administration, Oral. Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Arachnoid. Cerebellar Diseases / diagnosis. Cerebellar Neoplasms / diagnosis. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Pia Mater. Radiotherapy Dosage. Time Factors

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  • (PMID = 16160923.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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48. Kondziolka D, Madhok R, Lunsford LD, Mathieu D, Martin JJ, Niranjan A, Flickinger JC: Stereotactic radiosurgery for convexity meningiomas. J Neurosurg; 2009 Sep;111(3):458-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Meningiomas of the cerebral convexity are often surgically curable because both the mass and involved dura mater can be removed.
  • The WHO tumor grades in patients with prior resections were Grade I in 34 patients, Grade II in 15 patients, and Grade III in 6 patients.
  • Seventy patients underwent primary radiosurgery and therefore had no prior histological tumor diagnosis.
  • The mean tumor volume was 7.6 ml.
  • Radiosurgery was performed using the Leksell Gamma Knife with a mean tumor margin dose of 14.2 Gy.
  • After primary radiosurgery, the tumor control rate was 92%.
  • The actuarial tumor control rates at 3 and 5 years for the entire series were 86.1+/-3.8% and 71.6+/-8.6%, respectively.
  • For patients with benign tumors (Grade I) and those without prior surgery, the actuarial tumor control rate was 95.3+/-2.3% and 85.8+/-9.3%, respectively.
  • No patient developed a subsequent radiation-induced tumor.
  • CONCLUSIONS: Stereotactic radiosurgery provides satisfactory control rates either after resection or as an alternate to resection, particularly for histologically benign meningiomas.
  • Both temporary and permanent morbidity are related to brain location and tumor volume.
  • [MeSH-minor] Female. Humans. Male. Neurofibromatosis 2 / complications. Treatment Outcome. Tumor Burden

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  • (PMID = 19199473.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Kobayashi H, Ishii N, Murata J, Saito H, Kubota KC, Nagashima K, Iwasaki Y: Cystic meningioangiomatosis. Pediatr Neurosurg; 2006;42(5):320-4
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  • A case of cerebral meningioangiomatosis with rare cyst formation is reported.
  • Neuroradiological studies showed an abnormal cystic mass with calcification in the left frontal lobe of the cerebrum.
  • The tumor was located in the leptomeninges and cerebral cortex.
  • It is important to distinguish meningioangiomatosis from other possible cortical lesions and epileptic foci should be carefully considered before resection, because it is a benign and surgically manageable cause of seizures.
  • [MeSH-major] Angiomatosis / surgery. Brain Diseases / surgery. Cerebral Cortex / surgery. Meninges / surgery

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16902347.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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50. Pascual Castroviejo I, Pascual Pascual S, Velázquez Fragua R, Viaño J, Garcia Segura JM: [Brain stem tumors associated with neurofibromatosis type 1. Presentation of 20 infantile patients]. Neurologia; 2007 Dec;22(10):846-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumores de tronco cerebral asociados con neurofibromatosis tipo 1. Presentación de 20 pacientes infantiles.
  • Thirteen of the 20 patients (65 %) also had optic pathway tumor.
  • Brain stem tumor identification occurred at the same time as NF1 in the patients who were studied by MR at the time of the first consult.
  • Diffuse or localized medullary enlargement was the most frequent MR imaging and appeared in 13 patients (65%), followed by the tumor that involved all brain stem (pontine and medullary areas) that appeared in 6 patients (30 %).
  • In the last group, one tumor showed extension through brain stem and medial cerebellar parts, another was located in the aqueduct and in the periaqueductal areas and showed slow progressive growth, and one third patient had a tumor with aggressive signs in the SMR study.
  • Another patient had an aggressive tumor that involved the left optic nerve, chiasm, mesencephalon and upper right pontine areas.
  • The histological study of the tumoral biopsic tissue of the two last patients showed astrocitoma degree 1 (benign tumor).
  • Only one of the 20 patients died, although it was due to a malignant chiasmatic tumor, that had been treated twenty years before, and not by the brain stem tumor.
  • MR and SMR are necessary to a correct identification of the tumor in some patients.
  • Most of these tumors are benign.


51. Dapena-Sevilla I, Drake-Rodríguez P, Gutiérrez-Ortiz C, Bolívar G, Castejón M, Teus-Guezala MA: [Band atrophy of the optic disc secondary to ventricular subependymoma compression]. Arch Soc Esp Oftalmol; 2007 Sep;82(9):567-9
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  • Craniotomy and tumor resection were performed.
  • Subependymomas are infrequent and benign tumors that are typically associated with the ventricular system.
  • [MeSH-major] Cerebral Ventricle Neoplasms / complications. Glioma, Subependymal / complications. Optic Atrophy / etiology

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  • (PMID = 17846949.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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52. Waltereit R, Welzl H, Dichgans J, Lipp HP, Schmidt WJ, Weller M: Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis. J Neurochem; 2006 Jan;96(2):407-13
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  • TSC starts in early childhood and is characterized by cerebral hamartomas (benign tumours), severe epilepsy and cognitive deficits such as mental retardation and autism.
  • The hamartomas are characterized by loss of the remaining wild-type TSC allele, and clinical data implicate cerebral hamartomas in the generation of epileptic seizures, which may play a significant role in the development of mental retardation.
  • We therefore hypothesized that the heterozygous mutation itself, besides cerebral hamartomas, contributes to the pathogenesis of cognitive deficits and possibly also epilepsy.
  • Here, we show that young adult TSC2+/- rats, which are virtually free of cerebral hamartomas, exhibit enhanced episodic-like memory and enhanced responses to chemically-induced kindling.
  • [MeSH-major] Epilepsy / etiology. Kindling, Neurologic. Memory, Short-Term. Mutation. Tuberous Sclerosis / genetics. Tuberous Sclerosis / psychology. Tumor Suppressor Proteins / genetics

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  • [CommentIn] Epilepsy Curr. 2006 Nov-Dec;6(6):210-2 [17260062.001]
  • (PMID = 16300636.001).
  • [ISSN] 0022-3042
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1
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53. Martinez-Glez V, Franco-Hernandez C, Alvarez L, De Campos JM, Isla A, Vaquero J, Lassaletta L, Casartelli C, Rey JA: Meningiomas and schwannomas: molecular subgroup classification found by expression arrays. Int J Oncol; 2009 Feb;34(2):493-504

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microarray gene expression profiling is a high-throughput system used to identify differentially expressed genes and regulation patterns, and to discover new tumor markers.
  • As the molecular pathogenesis of meningiomas and schwannomas, characterized by NF2 gene alterations, remains unclear and suitable molecular targets need to be identified, we used low density cDNA microarrays to establish expression patterns of 96 cancer-related genes on 23 schwannomas, 42 meningiomas and 3 normal cerebral meninges.
  • Results showed a high frequency of NF2 gene mutations (40%), increased 22q LOH as aggressiveness increased, frequent losses and gains by MLPA in benign meningiomas, and gene expression silencing by hypermethylation.
  • Unsupervised analyses identified 2 molecular subgroups for both meningiomas and schwannomas showing 38 and 20 differentially expressed genes, respectively, and 19 genes differentially expressed between the two tumor types.
  • [MeSH-minor] Adult. Aged. DNA, Complementary / genetics. DNA, Neoplasm / genetics. Female. Gene Deletion. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Repeats / genetics. Middle Aged. Neurofibromatosis 2 / genetics

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  • (PMID = 19148485.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Neoplasm
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54. Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ: Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience; 2008 Jan 24;151(2):476-88
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  • The tumor-suppressor phosphatase with tensin homology (PTEN) is the central negative regulator of the PI3K pathway.
  • Germline PTEN mutations result in cancer predisposition, macrocephaly and benign hamartomas in many tissues, including Lhermitte-Duclos disease, a cerebellar growth disorder.
  • Electron microscopic evaluation revealed enlarged abnormal synaptic structures in the cerebral cortex and cerebellum.

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  • (PMID = 18082964.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA096832-01A10004; United States / NCI NIH HHS / CA / CA096832; United States / NINDS NIH HHS / NS / R01 NS044172; United States / NINDS NIH HHS / NS / NS044172; United States / NCI NIH HHS / CA / P01 CA096832-05; United States / NCI NIH HHS / CA / P01 CA096832; United States / NCI NIH HHS / CA / CA096832-05; United States / NCI NIH HHS / CA / P01 CA096832-01A10004
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS39023; NLM/ PMC2278004
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55. Hamlat A, Le Strat A, Guegan Y, Ben-Hassel M, Saikali S: Cerebellar pleomorphic xanthoastrocytoma: case report and literature review. Surg Neurol; 2007 Jul;68(1):89-94; discussion 94-5
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  • BACKGROUND: PXA generally has histologic features characteristic of benign biological behavior, although malignant forms have been reported.
  • This neoplasm has also been observed in atypical locations.
  • METHODS: The authors report a case of cerebellar PXA with rapid malignant transformation in a 58-year-old woman and review the rare presentations and atypical features of this tumor.
  • PXA in the posterior fossa had a higher rate of solid enhancing tumor (9/14).
  • CONCLUSIONS: The clinicopathologic features of cerebellar PXA show some differences from PXA located in the cerebral hemispheres.

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  • (PMID = 17537486.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
  • [Number-of-references] 28
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56. Ulivieri S, Oliveri G: Intraventricular neurocytoma: case report. Pathologica; 2007 Oct;99(5):309-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraventricular neurocytoma is a rare, usually benign tumour of neuronal differentiation, recently recognized as a clinico-pathological entity in comparison to the other intraventricular tumours.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurocytoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Corpus Callosum / pathology. Craniotomy. Humans. Male. Synaptophysin / analysis

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  • (PMID = 18354953.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Synaptophysin
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57. Samadi N, Ahmadi SA: Meningioma: a clinicopathological evaluation. Malays J Med Sci; 2007 Jan;14(1):46-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 205(86.1%) cases were benign, 19(8%) atypical and 14(5.9%) malignant.
  • 181(18%) cases were primary and 51(27%) secondary; 35(68%) of the latter benign, 7(14%) atypical and 9(18%) malignant.
  • All intraspinal meningiomas were benign.
  • In benign cranial and spinal types female to male ratios were 1.9: 1 and 1.3: 1 ; while in atypical and malignant types were 1 :1.4 and 1:3.1 respectively.
  • Mean ages were 49.9 for benign.
  • The most frequent site of involvement in all grades of intracranial tumors was cerebral convexity (31.1 %).
  • Female preponderance seen in benign nonrecurrent meningioma became increasingly less prominent and even reversed in recurrent, atypical and malignant forms.
  • Benign recurrent tumors were similar to non-recurrent tumors microscopically.

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  • (PMID = 22593651.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3351217
  • [Keywords] NOTNLM ; Mahmood grading system / WHO grading system / brain tumor / intracranial / intraspinal / meningioma
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58. Hałoń A, Patrzałek DJ, Boratyńska M, Wolański M, Hałoń Ł: Kidney donation from a patient with cardiac myxoma: a case report. Transplant Proc; 2008 May;40(4):1073-8
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  • A significant percentage of donors may be found among patients primarily suffering from benign neoplasms whose nature does not show malignant potential and do not metastasize.
  • AIM: The aim of this report was to present a successful transplantation of cadaveric kidney grafts from a 61-year-old female donor with a left atrial cardiac myxoma, which initially appeared as an embolic cerebral infarct.
  • CONCLUSION: Patients with myxoma should be accepted as donors, since the risk of dying on the waiting list is greater than the tumor transfer risk.

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  • (PMID = 18555118.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Gessi M, Legnani FG, Maderna E, Casali C, Solero CL, Pollo B, DiMeco F: Mucinous low-grade adenocarcinoma arising in an intracranial enterogenous cyst: case report. Neurosurgery; 2008 Apr;62(4):E972-3; discussion E973
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  • OBJECTIVE: Enterogenous cysts (ECs) of the central nervous system are developmental malformations that occur in the spinal canal, posterior fossa, or cerebral hemispheres.
  • They are usually benign lesions, and malignant transformation is rare.
  • Subsequent follow-up computed tomographic scans showed progression of the residual tumor.

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  • (PMID = 18496166.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Deb P, Sarkar C, Garg A, Singh VP, Kale SS, Sharma MC: Intracranial gliofibroma mimicking a meningioma: a case report and review of literature. Clin Neurol Neurosurg; 2006 Feb;108(2):178-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gliofibromas are rare glio-mesenchymal tumors composed of astrocytic and benign mesenchymal components, which commonly occur in the first two decades of life.
  • Post-operatively, the residual tumor regrew to a size similar to the initial mass (4 cm x 3.6 cm x 3.5 cm), within one and a half years after the first surgery.
  • The histopathology of the tumor was similar on both occasions.
  • Although a poor prognosis has been characteristically noted in gliofibromas with high-grade glial component, but the present case had recurrence despite being of low-grade, thus highlighting the uncertain behaviour of this rare tumor.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Fibroma / diagnosis. Glioma / diagnosis. Meningioma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Third Ventricle

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  • (PMID = 16412839.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 24
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61. Sarnat HB, Flores-Sarnat L: Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J Child Neurol; 2005 Aug;20(8):637-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Abnormal angiogenesis, areas of abnormal pigmentation that sometimes follow the lines of Blashko, nerve sheath proliferations, disorders of chromaffin tissue, lipomes and benign and malignant tumors are frequent features.
  • Many defective genes in neurocutaneous syndromes have an additional function as tumor suppressors.
  • The craniofacial abnormalities associated with many cerebral malformations and cutaneous lesions in some neurocutaneous syndromes emphasize an important inductive role of the neural tube in the development of non-neural tissues, mediated through neural crest.

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  • (PMID = 16225807.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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62. Benedict WJ Jr, Brown HG, Sivarajan G, Prabhu VC: Intraventricular schwannoma in a 15-year-old adolescent: a case report. Childs Nerv Syst; 2008 Apr;24(4):529-32
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  • INTRODUCTION: Schwannomas are benign tumors that originate from the myelin-forming Schwann cells of peripheral nerves or at the Obersteiner-Redlich zone of the vestibular division of the eighth cranial nerve.
  • DISCUSSION: This case report illustrates a right occipital horn schwannoma in a 15-year-old adolescent boy who was successfully treated with surgical resection and discusses the possible origins of the tumor in this unique location.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 18175126.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 13
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63. Shingu T, Akiyama Y, Daisu M, Maruyama N, Matsumoto Y, Miyazaki T, Nagai H, Yamamoto Y, Yamasaki T, Yoshida M, Maruyama R, Moritake K: Symptomatic hemorrhage associated with recurrent pilocytic astrocytoma with granulation tissue--case report. Neurol Med Chir (Tokyo); 2007 May;47(5):222-8
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  • Computed tomography and T(2)*-weighted magnetic resonance imaging revealed hemorrhage in the tumor located in the right basal ganglia, thalamus, and hypothalamus.
  • Although neither symptomatic hemorrhage nor late benign recurrence is common, careful long-term follow up is necessary for patients with pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebral Hemorrhage / etiology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17527050.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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64. Benouaiche L, Couly G, Michel B, Devauchelle B: [Diagnosis and management of cervicofacial congenital teratomas: about 4 cases, literature review and restatement]. Ann Chir Plast Esthet; 2007 Apr;52(2):114-23
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  • Cervicofacial teratomas are rare developmental lesions, more often benign in their histology.
  • Prenatal diagnosis raises on ultrasound examination precising locoregional consequences of the tumor and surgical possibilities.
  • In the propitious cases, prenatal MRI examination is useful to precise tumor's limits and cerebral status of the foetus.

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  • (PMID = 17030386.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 37
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65. Rushing EJ, Cooper PB, Quezado M, Begnami M, Crespo A, Smirniotopoulos JG, Ecklund J, Olsen C, Santi M: Subependymoma revisited: clinicopathological evaluation of 83 cases. J Neurooncol; 2007 Dec;85(3):297-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported.
  • Eighteen-percent (15/83) of subependymomas exhibited a mixed histologic pattern; that is, subependymoma together with another glial tumor.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Ependymoma / pathology. Glioma, Subependymal / pathology. Infratentorial Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • (PMID = 17569000.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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66. Kuwashiro T, Toyoda K, Otsubo R, Ishibashi-Ueda H, Tagusari O, Minematsu K: Cardiac papillary fibroelastoma as a cause of embolic stroke: ultrasound and histopathological characteristics. Intern Med; 2009;48(1):77-80
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  • Although a cardiac papillary fibroelastoma is a benign cardiac tumor, it can cause severe embolic complications.
  • A 51-year-old man presented with an ischemic stroke in the right middle cerebral artery territory.
  • Transesophageal echocardiography revealed a small mobile tumor on the mitral valve as the only detectable source of emboli to the brain.
  • On histology, the tumor was diagnosed as a papillary fibroelastoma.
  • In this paper, the detailed characteristics of the tumor on ultrasound and histopathology are documented.

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  • (PMID = 19122362.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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67. Katakowski M, Jiang F, Zheng X, Gutierrez JA, Szalad A, Chopp M: Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. Cancer Sci; 2009 Sep;100(9):1597-604
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  • When implanted in the nude mouse brain, CTX-TNA2 cells induced low histological grade, benign intraventricular gliomas.

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  • (PMID = 19515085.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA043892-17; United States / NCI NIH HHS / CA / R01 CA100486-04; United States / NCI NIH HHS / CA / P01 CA043892; United States / NCI NIH HHS / CA / CA100486-04; United States / NCI NIH HHS / CA / R01 CA100486; United States / NCI NIH HHS / CA / P01 CA043892-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / tumor necrosis factor-alpha convertase
  • [Other-IDs] NLM/ NIHMS142282; NLM/ PMC2756136
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68. D'Angelo VA, Galarza M, Catapano D, Monte V, Bisceglia M, Carosi I: Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases. Neurosurgery; 2005 Jan;56(1 Suppl):36-45; discussion 36-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases.
  • We conducted a retrospective study of patients with these lesions treated with a surgical strategy on the basis of tumor origin: primary or secondary ventricular and associated transependymal development.
  • Sixty-five percent of tumors were benign and low-grade tumors.
  • CONCLUSION: Lateral ventricle tumors can be treated best by careful selection of the approach according to tumor origin and development.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Lateral Ventricles / surgery. Neurosurgical Procedures / methods. Telencephalon / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebral Ventriculography / methods. Child. Child, Preschool. Decision Making. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Neuropsychological Tests. Retrospective Studies

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  • [ReprintIn] Neurosurgery. 2008 Jun;62(6 Suppl 3):1066-75 [18695527.001]
  • (PMID = 15799791.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Cheng CH, Liu CL, Chen CC, Lin SZ, Cho DY: Single-port endoscopic removal of intraventricular central neurocytoma. J Clin Neurosci; 2010 Nov;17(11):1417-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Central neurocytoma is a rare benign intraventricular tumor which occurs in young adults.
  • Craniotomy with tumor removal is associated with relatively high rates of morbidity and mortality.
  • To improve the efficiency of endoscopic surgery for removal of this tumor, we used a polypropylene tube combined with a working channel endoscope.
  • The tumor was almost totally removed.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Endoscopy / methods. Neurocytoma / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Cerebral Ventricles / surgery. Female. Humans. Magnetic Resonance Imaging. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20655233.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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70. Bouaziz M, Mansour A, Feknous S, Yassi F, Smati S, Belhouchet S, Lankar A: [Central neurocytoma: case report]. Neurochirurgie; 2009 Dec;55(6):581-4
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  • It is a benign tumor of the lateral ventricles of the brain with neuronal differentiation.
  • [MeSH-major] Brain Neoplasms / surgery. Cerebral Ventricle Neoplasms / surgery. Neurocytoma / surgery

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  • (PMID = 19447451.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Chromatin; 0 / Synaptophysin
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71. Sentürk S, Oğuz KK, Cila A: Dynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3T MR scanner. Diagn Interv Radiol; 2009 Mar;15(1):3-12
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  • PURPOSE: To determine whether there are statistically significant differences in cerebral blood volume (CBV) and cerebral blood flow (CBF) of brain tumors of different histopathologic types including primary and secondary benign and malignant lesions.
  • To determine whether these measurements relate to tumor grade.
  • The lesions were evaluated by measurements of relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF).
  • The Mann-Whitney U test was used to compare rCBV and rCBF measurements of tumor groups -- 13 low-grade and 13 high-grade neuroepithelial (NE) tumors, five metastases, 10 meningiomas, and four others.
  • CONCLUSION: CBV and CBF measurements provided by 3T perfusion MRI can help to predict NE tumor grading preoperatively, and differentiate between primary brain tumors and metastases.

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  • (PMID = 19263367.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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72. Richards J, Ballard N: Colloid cyst: a case study. J Neurosci Nurs; 2008 Apr;40(2):103-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A colloid cyst, also called a neuroepithelial cyst, is a slow-growing, benign tumor that occurs in the anterior third ventricle.
  • Less common presenting signs and symptoms include nausea, vomiting, memory loss, mental status changes, gait disorder, and visual disturbances.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Cysts / diagnosis. Cysts / surgery. Third Ventricle

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  • (PMID = 18481740.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Takei H, Bhattacharjee MB, Adesina AM: Chordoid glioma of the third ventricle: Report of a case with cytologic features and utility during intraoperative consultation. Acta Cytol; 2006 Nov-Dec;50(6):691-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Chordoid glioma is a rare, low grade neoplasm with a unique chordoid appearance as well as distinct clinicopathologic and immunohistochemical features.
  • Intraoperative squash smears showed cellular sheets as well as nests and strands of epithelioid tumor cells with bland nuclei and polygonal to elongated cytoplasm in a mucinous background.
  • The tumor was intimately admixed with a benign lymphoplasmacytic infiltrate and scattered Russell bodies.
  • Histologically, the tumor cells were arranged in a syncytium with prominent lymphoplasmacytic infiltrates and scattered small foci of necrosis in a mucinous matrix.
  • Immunohistochemically, the tumor cells were positive for glial fibrillary acid protein (GFAP), vimentin, epithelial membrane antigen, CD34, neuron-specific enolase and CK-7 and negative for synaptophysin, S-100 protein, neurofilament, and estrogen and progesterone receptors.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cytodiagnosis / methods. Glioma / pathology. Third Ventricle
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Intraoperative Period. Magnetic Resonance Imaging. Meningioma / pathology

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  • (PMID = 17152286.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Pratheesh R, Moorthy RK, Singh R, Rajshekhar V: Choroid plexus papilloma presenting as a non-contrast-enhancing fourth ventricular mass in a child. Neurol India; 2009 Jul-Aug;57(4):486-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Choroid plexus papilloma (CPP) is a rare benign tumor of the central nervous system with a propensity for location within the lateral ventricle in children.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Fourth Ventricle / pathology. Papilloma, Choroid Plexus / diagnosis
  • [MeSH-minor] Adolescent. Cerebral Ventriculography / methods. Female. Humans. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed

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  • (PMID = 19770555.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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75. Saad A, Folkerth R, Poussaint T, Smith E, Ligon K: Meningioangiomatosis associated with meningioma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Meningioangiomatosis is a meningovascular disorder that only rarely occurs in association with a meningioma.
  • Occasionally, as in this case, imaging studies do not readily identify this disorder as a benign process.
  • In addition, this disorder may infiltrate the underlying cerebral cortex, simulating, intraoperatively, a malignant infiltrative process.
  • To allow better recognition of this disorder, we report a case with emphasis on the unique cytologic features of the 2 components (meningioangiomatosis and meningioma) and potential pitfalls in diagnosis.
  • Neuroimaging showed an ill-defined signal abnormality in the left frontal lobe suggestive of a high-grade tumor.
  • Tumor resection was performed, and intraoperative smear preparation showed meningioangiomatosis associated with meningioma.

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  • (PMID = 19248561.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Linke R, Voltz R: FDG-pet in paraneoplastic syndromes. Recent Results Cancer Res; 2008;170:203-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As tumor therapy still is the mainstay of treatment for paraneoplastic syndromes, early diagnosis of the initial tumor or its recurrence is of utmost clinical importance.
  • For finding the associated tumor, the combined use of FDG-PET and CT seems to have the highest sensitivity and may contribute to accurately distinguishing a true tumor or recurrence from benign lesions or physiologic or inflammatory uptake.
  • Further, this approach helps localize the tumor for further management of the patient such as surgery or more invasive diagnostic procedures.
  • Cerebral FDG-PET proved to confirm paraneoplastic encephalitis and may help monitor tumor therapy.

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  • (PMID = 18019628.001).
  • [ISSN] 0080-0015
  • [Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
  • [ISO-abbreviation] Recent Results Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 37
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77. Kalinichenko OV, Myshunina TM, Tron'ko MD: [B-, H- and L-cathepsin-like activity in blood plasma of patients with diseases of the thyroid, parathyroid and adrenal glands]. Ukr Biokhim Zh (1999); 2010 Mar-Apr;82(2):53-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In diaseses of the adrenal glands the changes in the B- and L-catepsine-like activity were only shown in the blood plasma of patients with cerebral layer tumors but not the gland cortex: B-catepsine-like activity increased in the blood plasma of patients with benign or malignant tumors, and L-catepsine-like activity decreased under benign tumor from chromaffin tissue.

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  • (PMID = 20684245.001).
  • [Journal-full-title] Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal (1999 )
  • [ISO-abbreviation] Ukr Biokhim Zh (1999)
  • [Language] ukr
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] EC 3.4.22.1 / CTSB protein, human; EC 3.4.22.1 / Cathepsin B; EC 3.4.22.15 / CTSL1 protein, human; EC 3.4.22.15 / Cathepsin L; EC 3.4.22.16 / CTSH protein, human; EC 3.4.22.16 / Cathepsin H
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78. Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, García-Guereta L, López-Gutiérrez JC, Olivares P, Tovar J: Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients. Neuropediatrics; 2010 Feb;41(1):7-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cutaneous hemangioma is a benign vascular tumor of infancy with an initial proliferating period that appears between 1 to 2 weeks of life, extends during 18 months to 2 years of life, and then slowly regresses during several years until it disappears completely.
  • These cutaneous anomalies are commonly associated with cerebellar malformations, main cerebral arteries anomalies, congenital cardiac anomalies and/or coarctation of the aorta and persistence of embryonic arteries.

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  • (PMID = 20571984.001).
  • [ISSN] 1439-1899
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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79. Waseem M, Atkuri L, Laureta E: A febrile child with seizure and hemiparesis. Pediatr Emerg Care; 2006 Nov;22(11):718-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although most febrile seizures are simple and benign, these seizures can infrequently create a diagnostic dilemma.
  • The diagnosis of cerebral venous thrombosis is challenging to emergency physicians because it can mimic the presentation of many other disorders, including ischemic and hemorrhagic stroke, tumor, and abscess.

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  • (PMID = 17110863.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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80. George B, Archilli M, Cornelius JF: Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases. Acta Neurochir (Wien); 2006 Jul;148(7):741-9; discussion 749
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Forty-one patients presenting a bone tumor (26 benign and 15 malignant tumors), excluding chordomas, located at the CCJ (including lower third of the clivus, C1 and C2) were observed over 20 years from 1981 to 2001.
  • No recurrence in the group of benign tumors was seen during an average follow-up of 6 years (from 2 to 11 years).
  • Confusion between benign and malignant tumor or pseudo tumors must be avoided, sometimes requiring a biopsy.
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebral Angiography. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck Pain / etiology. Neck Pain / physiopathology. Neck Pain / surgery. Neoplasm Metastasis / pathology. Neoplasm Metastasis / radiography. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Spinal Fusion. Tomography, X-Ray Computed. Treatment Outcome. Vertebral Artery / anatomy & histology. Vertebral Artery / pathology. Vertebral Artery / surgery

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  • (PMID = 16708168.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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81. Navas M, Pedrosa-Sánchez M, Martínez-Flórez P, Carrasco R, Pascual JM, Sola RG: [Giant cavernous sinus haemangioma. Case report]. Neurocirugia (Astur); 2009 Oct;20(5):461-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Hemangioma gigante del seno cavernoso. Caso clínico.
  • INTRODUCTION: Intracranial haemangioma is a benign vascular tumor which seldom affects the cavernous sinus region, being it frequently misdiagnosed as a meningioma.
  • The tumor was partially removed through a left pterional approach, leaving an intraselar remnant.
  • This entity represents a neurosurgical challenge, due to the complexity of this anatomical region and the trend of the tumour to bleed during its dissection.
  • [MeSH-minor] Cerebral Angiography. Diagnosis, Differential. Female. Hemangioma, Cavernous, Central Nervous System / complications. Hemangioma, Cavernous, Central Nervous System / diagnosis. Hemangioma, Cavernous, Central Nervous System / epidemiology. Hemangioma, Cavernous, Central Nervous System / radiography. Hemangioma, Cavernous, Central Nervous System / surgery. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Middle Aged. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19830369.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 23
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82. Oertel MF, Nolte KW, Blaum M, Weis J, Gilsbach JM, Korinth MC: Primary intraventricular schwannomas. Clin Neurol Neurosurg; 2009 Nov;111(9):768-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwann cell tumors arising within the neuraxis and in an intraventricular location are an exceedingly rare tumor entity of the brain.
  • A 71-year-old female was admitted to the hospital with an incidental finding of a ventricular tumor.
  • Microsurgical excision via a midline suboccipital craniotomy and tonsillo-nodular approach led to complete tumor removal.
  • A unique case of an initially unexpected benign schwannoma arising from the fourth ventricle that could be successfully treated by microsurgery and finally confirmed by histopathological analysis with excellent patient outcome is presented.
  • Although highly uncommon, Schwann cell tumors of both benign and malignant nature may present as ventricular lesions and should be included as a differential diagnosis in patients with either solely intraventricular masses or intra- and extraaxial tumors with extension to the ventricles.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 19632768.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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83. Fon LJ, Lioe TF, Mulligan KA, Johnston PG, McCormick D, Spence RA: Prognostic significance of glycoprotein pMQ1 in breast cancer. Br J Surg; 2006 Mar;93(3):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cerebral metastases from breast cancer have also been found to contain pMQ1-positive cells.
  • The surrounding normal tissue margins and benign breast tissues always lacked pMQ1 expression.
  • CONCLUSION: pMQ1 appears to be a tumour-associated protein.
  • [MeSH-major] Breast Neoplasms / chemistry. Glycoproteins / analysis. Neoplasm Proteins / analysis
  • [MeSH-minor] Adult. Aged. Breast / chemistry. Female. Follow-Up Studies. Humans. Ki-67 Antigen / analysis. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Receptors, Estrogen / analysis. Tumor Suppressor Protein p53 / analysis

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 16392102.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; 0 / pMQ1 glycoprotein, human
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84. Ahn ES, Chin LS, Gyure KA, Hudes RS, Ragheb J, DiPatri AJ Jr: Long-term control after resection and gamma knife surgery of an intracranial clear cell meningioma: case report. J Neurosurg; 2005 Apr;102(3 Suppl):303-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Authors have described its propensity to recur and metastasize despite its benign pathological characteristics.
  • Initially, the residual tumor decreased in size, but 6 years later, it had regrown (9 mm in size).
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Stereotaxic Techniques
  • [MeSH-minor] Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Child. Dominance, Cerebral / physiology. Female. Follow-Up Studies. Glycogen / metabolism. Humans. Image Enhancement. Magnetic Resonance Imaging. Neurologic Examination. Reoperation. Temporal Lobe / pathology. Temporal Lobe / surgery. Tomography, X-Ray Computed

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  • (PMID = 15881755.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9005-79-2 / Glycogen
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85. Naydenov E, Tzekov C, Minkin K, Nachev S, Marinov M: [Malignant progression of an anaplastic ganglioglioma into a glioblastoma multiforme--report on two cases and review of the literature]. Khirurgiia (Sofiia); 2009;(2-3):69-74
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  • In most of the cases the tumor demonstrates benign clinical behaviour with long-term patients' survival.
  • The tumor was excised partially and the histological result was anaplastic ganglioglioma (World Health Organization - WHO. gr. III).
  • A local tumor recurrence was found and the patient underwent second operative intervention with gross total tumor resection.
  • An involvement of the contralateral cerebral hemisphere was found on control CT-scan ten months later.
  • MRI data for large, heterointense tumor lesion in the left frontal lobe was found.
  • A subtotal tumor removal was made.
  • Data for additional local tumor growth was found on control CT-scan one month later.
  • The tumor behaviour may vary between the patients in spite of the similar histological characteristics which indicates the possible presence of different tumor subtypes.
  • [MeSH-major] Brain Neoplasms / pathology. Ganglioglioma / pathology. Glioblastoma / pathology. Neoplasm Recurrence, Local / pathology


86. Liu AK, Bagrosky B, Fenton LZ, Gaspar LE, Handler MH, McNatt SA, Foreman NK: Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy. Pediatr Blood Cancer; 2009 Feb;52(2):227-30
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  • BACKGROUND: Craniopharyngioma is a benign brain tumor that can be treated with some combination of surgery, intracystic chemotherapy and radiation therapy.
  • One had bilateral temporal cavernomas, one had moyamoya syndrome, one had an aneurysm of the internal carotid artery and three children had decreases in the caliber of the carotid or cerebral arteries, but were asymptomatic.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18937328.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin
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87. Giuşcă S, Jurcuţ R, Serban M, Popescu BA, Apetrei E, Ginghină C: Cardiac tumors: the experience of a tertiary cardiology center. Rom J Intern Med; 2007;45(4):333-9

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  • RESULTS: In the CTum group (49 +/- 16.2 years, similar between men and women), the main symptoms leading to patients referral were dyspnea (15 pts, 62.5%) and embolic events (coronary, cerebral, peripheral arteries: 7 pts, 29%), while in 4 asymptomatic pts the diagnosis was incidental.
  • In 20 pts (83%), TTE and transesophageal echocardiography (TEE) provided all the data required for preoperative assessment (tumor size, extension, location, insertion site).
  • The imaging techniques suggested a diagnosis of benign tumor in 15 pts (62.5%) and malignant tumor in 5 pts.
  • In 4 pts the tumor type could not be established.
  • In the case of benign tumors, surgery must be performed as soon as possible after the diagnosis has been established, whereas for malignant tumors there is still much controversy in what regards the benefits of surgery.

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  • (PMID = 18767408.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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88. Ragel BT, Osborn AG, Whang K, Townsend JJ, Jensen RL, Couldwell WT: Subependymomas: an analysis of clinical and imaging features. Neurosurgery; 2006 May;58(5):881-90; discussion 881-90
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  • OBJECTIVE: Subependymomas are slow-growing, benign tumors usually found incidentally in the fourth ventricle at autopsy.
  • RESULTS: Twelve of these subependymomas were intraventricular, one was in the posterior fossa, two were intraparenchymal, and one was an intramedullary spinal cord tumor.
  • Clinical symptoms were associated with tumor location: intracranial masses caused headaches, seizures, and neurological complaints, and spinal cord locations resulted in neurological deficit.
  • The authors review the clinical presentation, management, and contemporary radiographic appearance of this rare tumor.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Glioma, Subependymal / diagnosis. Glioma, Subependymal / surgery. Magnetic Resonance Imaging

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  • (PMID = 16639322.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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89. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults.
  • The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis.
  • To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease).
  • Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.
  • [MeSH-major] Angiomatosis / complications. Angiomatosis / pathology. Cerebral Hemorrhage / complications. Cerebral Hemorrhage / pathology. Histiocytoma, Benign Fibrous / complications. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Hsu TR, Wong TT, Chang FC, Ho DM, Tang RB, Thien PF, Chang KP: Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst; 2008 Dec;24(12):1457-61
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  • BACKGROUND: Though the pathology of optic pathway tumor is mostly pilocytic astrocytoma, the benign tumor behaves like malignant tumor because total resection is not feasible.
  • We evaluate the responsiveness of optic pathway tumor to cisplatin-based chemotherapy.
  • The toxicity of the cisplatin-based chemotherapy showed mild bone marrow suppression in 13 patients (81.3%), infection in nine patients (56.3%), gastrointestinal discomfort in seven patients (43.8%), renal insufficiency in two patient (12.5%), cerebral salt wasting syndrome with hyponatremia in one patient (6.25%) and high pitch hearing loss in two patients (12.5%).

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  • (PMID = 18769928.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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91. Houtteville JP: [Cavernomas of the central nervous system. Historical data and changing ideas]. Neurochirurgie; 2007 Jun;53(2-3 Pt 2):117-21
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  • Since the advent of modern neuroimaging (MRI) cerebral cavernomas are usually diagnosed "in vivo".
  • 1) nosologically, cerebral cavernomas belong to the group of cerebral vascular hamartomas which can be associated between themselves ("mixed" lesions);.
  • 4) immunocytochemical studies (PCNA) show that cavernomas should be considered more as a benign vascular tumor than as a malformation;.

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  • (PMID = 17499816.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 14
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92. Ceyssens S, Van Laere K, de Groot T, Goffin J, Bormans G, Mortelmans L: [11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence. AJNR Am J Neuroradiol; 2006 Aug;27(7):1432-7
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  • METHODS: Cerebral uptake of MET was determined in 52 patients: in 26 patients for primary staging (group A) and 26 patients with suspected brain tumor recurrence/progression after therapy (group B).
  • Semiquantitative methionine uptake indices (UI) defined by the tumor (maximum)-to-background ratio was correlated with tumor grade and final outcome.
  • Although a weak linear correlation between MET uptake and grading was observed (R = 0.38, P = .028), analysis of variance showed no significant differences in MET UI between tumor grades for either group A or B.
  • Benign and grade I lesions showed significant difference in MET uptake in comparison with higher grade lesions (P = .006).
  • [MeSH-major] Brain Neoplasms / radionuclide imaging. Carbon Radioisotopes. Glioma / radionuclide imaging. Methionine. Neoplasm Recurrence, Local / pathology. Positron-Emission Tomography / methods. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / pathology. Astrocytoma / radionuclide imaging. Astrocytoma / therapy. Brain / metabolism. Child. Child, Preschool. Disease Progression. Female. Forecasting. Humans. Male. Middle Aged. Neoplasm Staging. Oligodendroglioma / pathology. Oligodendroglioma / radionuclide imaging. Oligodendroglioma / therapy. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 16908552.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 0 / Radiopharmaceuticals; AE28F7PNPL / Methionine
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93. Akamatsu Y, Utsunomiya A, Suzuki S, Endo T, Suzuki I, Nishimura S, Ezura M, Suzuki H, Uenohara H, Tominaga T: Subependymoma in the lateral ventricle manifesting as intraventricular hemorrhage. Neurol Med Chir (Tokyo); 2010;50(11):1020-3
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  • Cerebral angiography revealed no abnormal findings.
  • Magnetic resonance imaging at 5 weeks after admission showed a tumor arising from the septum pellucidum or the floor of the right lateral ventricle, appearing as a mixed-intensity solid tumor, which was partially enhanced following gadolinium administration.
  • The tumor had arisen from the septum pellucidum and was totally removed via an interhemispheric anterior transcallosal approach.
  • Intraventricular hemorrhage from cerebral neoplasms is usually due to highly vascular tumors.
  • Since subependymomas are quite benign and show poor vascularity, intraventricular or subarachnoid hemorrhages are very rare, but do occasionally occur.
  • [MeSH-major] Cerebral Hemorrhage / etiology. Cerebral Ventricle Neoplasms / complications. Cerebral Ventricle Neoplasms / diagnosis. Glioma, Subependymal / complications. Glioma, Subependymal / diagnosis. Lateral Ventricles / pathology

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  • (PMID = 21123990.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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94. Schiopu C, Flangea C, Capitan F, Serb A, Vukelić Z, Kalanj-Bognar S, Sisu E, Przybylski M, Zamfir AD: Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry. Anal Bioanal Chem; 2009 Dec;395(8):2465-77
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  • We report here on a preliminary investigation of ganglioside composition and structure in human hemangioma, a benign tumor in the frontal cortex (HFC) in comparison to normal frontal cortex (NFC) tissue using for the first time advanced mass spectrometric methods based on fully automated chip-nanoelectrospray (nanoESI) high-capacity ion trap (HCT) and collision-induced dissociation (CID).
  • This aspect suggests that these O-acetylated structures could be associated with cerebral tumors having reduced malignancy grade.
  • Fragmentation analysis by CID in MS(2) mode using as precursors the ions corresponding to GT1 (d18:1/20:0) and GD1 (d18:1/20:0) provided data corroborating for the first time the presence of the common GT1a and GT1b isomers and the incidence of unusual GT1c and GT1d glycoforms in brain hemangioma tumor.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Gangliosides / chemistry. Gangliosides / metabolism. Hemangioma / metabolism. Spectrometry, Mass, Electrospray Ionization / methods. Tandem Mass Spectrometry / methods
  • [MeSH-minor] Adult. Brain / metabolism. Case-Control Studies. Cerebral Cortex / metabolism. Frontal Lobe / metabolism. Humans. Isomerism. Male. N-Acetylneuraminic Acid / analysis. Nanotechnology

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  • (PMID = 19841910.001).
  • [ISSN] 1618-2650
  • [Journal-full-title] Analytical and bioanalytical chemistry
  • [ISO-abbreviation] Anal Bioanal Chem
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gangliosides; GZP2782OP0 / N-Acetylneuraminic Acid
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95. Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T: Early malignant transformation of a petroclival meningothelial meningioma. Neurosurg Rev; 2009 Oct;32(4):495-9
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  • The tumor was subtotally removed and was diagnosed to be a meningothelial meningioma.
  • Seven months after surgery, a recurrence of the tumor was confirmed.
  • The diagnosis of this recurrent tumor was an atypical meningioma.
  • The MIB-1 index and the percent of p53 protein-positive cells in the primary tumor were 4.6% and 35.4%, respectively, whereas those of the recurrent tumor were 34.7% and 33.1%, respectively.
  • These results suggest that the present case had a potentially malignant tumor in the early stage, although it had the histological features of benign meningiomas.
  • [MeSH-minor] Cell Transformation, Neoplastic. Cerebral Angiography. DNA / genetics. Female. Gait Disorders, Neurologic. Gene Dosage. Hearing Disorders / etiology. Humans. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Meningeal Arteries / surgery. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19533187.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 9007-49-2 / DNA
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96. Chen CM, Chen KH, Jung SM, Hsu HC, Wang CM: Central neurocytoma: 9 case series and review. Surg Neurol; 2008 Aug;70(2):204-9
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  • Whether the high score of functional outcome was correlated with benign tumor course or 5-year survival rate remains uncertain.
  • We recommend regular follow-up for detecting tumor growth or recurrence, although central neurocytomas are always benign.
  • [MeSH-minor] Activities of Daily Living. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebral Angiography. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Glial Fibrillary Acidic Protein / metabolism. Humans. Ki-67 Antigen / analysis. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. Neurosurgical Procedures / methods. Radiotherapy / methods. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18262625.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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97. Bakoyiannis KC, Georgopoulos SE, Klonaris CN, Tsekouras NS, Felekouras ES, Pikoulis EA, Griniatsos JE, Papalambros EL, Bastounis EA: Surgical treatment of carotid body tumors without embolization. Int Angiol; 2006 Mar;25(1):40-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: Carotid body (CB) paragangliomas are rare neoplasms, usually benign.
  • Twelve tumors were surgically resected and no patient underwent preoperative selective embolism of his tumor.
  • No stroke or any other cerebral event was observed.
  • One patient, with a grade III tumor, had an injury of the internal carotid artery that was repaired with a vein patch.
  • Preoperative embolism of the tumor does not need to be a routine procedure.
  • [MeSH-major] Carotid Body Tumor / surgery. Endarterectomy, Carotid
  • [MeSH-minor] Adult. Aged. Angioplasty. Female. Humans. Male. Medical Records. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16520723.001).
  • [ISSN] 0392-9590
  • [Journal-full-title] International angiology : a journal of the International Union of Angiology
  • [ISO-abbreviation] Int Angiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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98. Bicer M, Cikirikcioglu M, Pektok E, Müller H, Dettwiler S, Kalangos A: Papillary fibroelastoma of the left atrial wall: a case report. J Cardiothorac Surg; 2009;4:28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cardiac papillary fibroelastoma is a rare, benign cardiac tumor.
  • Despite their benign histology, and independent of their size, they should be resected surgically because of their high potential for embolization.
  • In this report, we present a case of papillary fibroelastoma located on the left atrial wall, presenting with symptoms of cerebral ischemia.
  • Pertinent literature is also reviewed for this rare and benign cardiac tumor.

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  • (PMID = 19570232.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC2715399
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99. Dutta D, Vanere P, Gupta T, Munshi A, Jalali R: Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study. J Neurooncol; 2009 Aug;94(1):103-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Patients with brain tumors have varied degree of functional and psychological impairments because of factors relating to the tumor or to the treatment they receive.
  • MATERIAL AND METHOD: From August 2007 to April 2008, 150 consecutive adult (>18 years) primary brain tumor patients (median age 40 years; male 88, female 62) registered in a general out-patient neuro-oncology clinic were accrued and detailed data were recorded.
  • Seventy percent had malignant tumor (66% high-grade and 34% low-grade; 70% intra-axial).
  • Univariate analysis showed total FIM-FAM scores not significantly different with age (< or =35 years vs. >35 years; P = 0.994), sex (male versus female; P = 0.133), and grade of the tumor (high-grade versus low-grade; P = 0.142) but were significantly higher in patients with a Karnofsky performance score (KPS) of > or =70 as compared with <70 (P = 0.001), neurological performance scale (NPS) of 0 or 1 vs. 2 or 3; P = 0.001), disease type (benign versus malignant; P = 0.001), and site of disease (cerebral versus cerebellar; P = 0.024).
  • A trend for correlation between tumor sites with the corresponding function as assesses on the FIM-FAM score was observed.
  • There is strong correlation with age, type of tumor, and site of disease with different functional and cognitive domain impairment.

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  • (PMID = 19255726.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Romano A, Chibbaro S, Makiese O, Marsella M, Mainini P, Benericetti E: Endoscopic removal of a central neurocytoma from the posterior third ventricle. J Clin Neurosci; 2009 Feb;16(2):312-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Central neurocytoma is a rare benign tumor that most commonly arises within the ventricular system of young adults.
  • The patient underwent endoscopic assisted gross total resection of the tumor with the aid of intraoperative laser followed by standard third ventriculostomy; no further treatment was required.
  • Serial post-operative MRIs show neither residual nor recurrent tumor.
  • Thus, posterior third ventricle central neurocytomas are relatively benign tumors that can be successfully removed using a minimally invasive approach, thereby avoiding both the morbidity related to conventional open craniotomy and the potential toxicity of any adjuvant treatment.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Endoscopy / methods. Neurocytoma / surgery. Third Ventricle / surgery
  • [MeSH-minor] Adult. Cerebral Angiography / methods. Female. Humans. Magnetic Resonance Imaging. Ventriculostomy / methods

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  • (PMID = 19084413.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Technical Report
  • [Publication-country] Scotland
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