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1. Zustin J, Akpalo H, Gambarotti M, Priemel M, Rueger JM, Luebke AM, Reske D, Lange C, Pueschel K, Lohmann C, Rüther W, Amling M, Alberghini M: Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study. Am J Pathol; 2010 Sep;177(3):1072-8
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  • [Title] Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study.
  • Chondromyxoid fibroma represents a rare benign cartilaginous tumor of young patients occurring in a subcortical metaphyseal location.
  • The histogenesis of chondromyxoid fibroma has not yet been postulated, even though the conventional histology and recent immunohistochemical studies on phenotype of the mesenchymal cells and extracellular matrix components suggested its origin in immature cartilage.
  • Therefore, we wished to compare the morphological pattern of immature cartilage tissue with chondromyxoid fibroma to investigate a possible developmental counterpart of chondromyxoid fibroma.
  • Vascularized cartilage canals growing into the fetal cartilage from the perichondrium displayed characteristic glomeruloid structures with central arterioles within the immature mesenchymal stroma and numerous superficial sinusoidal blood vessels accompanied by macrophage infiltration.
  • Based on the observed substantial morphological similarity between the cartilage canals and chondromyxoid fibroma, we suggest that the chondromyxoid fibroma represents a neoplasm originating from or mimicking the fetal cartilage canals within the immature cartilage.
  • [MeSH-major] Cartilage / pathology. Chondroma / pathology. Femoral Neoplasms / pathology. Fibroma / pathology

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  • (PMID = 20671262.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2928941
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2. Romeo S, Duim RA, Bridge JA, Mertens F, de Jong D, Dal Cin P, Wijers-Koster PM, Debiec-Rychter M, Sciot R, Rosenberg AE, Szuhai K, Hogendoorn PC: Heterogeneous and complex rearrangements of chromosome arm 6q in chondromyxoid fibroma: delineation of breakpoints and analysis of candidate target genes. Am J Pathol; 2010 Sep;177(3):1365-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma (CMF) is an uncommon benign cartilaginous tumor of bone usually occurring during the second decade of life.
  • Two known tumor suppressor genes map to the latter region: PLAGL1 and UTRN.
  • [MeSH-major] Bone Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 6. Fibroma / genetics
  • [MeSH-minor] Cartilage / metabolism. Cartilage / pathology. Cytogenetic Analysis. Humans. Immunohistochemistry. In Situ Hybridization. Polymerase Chain Reaction. Repressor Proteins / genetics. Repressor Proteins / metabolism. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism. Utrophin / genetics. Utrophin / metabolism

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  • (PMID = 20696777.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCLAF1 protein, human; 0 / Repressor Proteins; 0 / Tumor Suppressor Proteins; 0 / Utrophin
  • [Other-IDs] NLM/ PMC2928969
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3. Thompson LD, Karamurzin Y, Wu ML, Kim JH: Solitary fibrous tumor of the larynx. Head Neck Pathol; 2008 Jun;2(2):67-74
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  • [Title] Solitary fibrous tumor of the larynx.
  • BACKGROUND: True mesenchymal, non-cartilaginous neoplasms of the larynx are rare.
  • Extrapleural solitary fibrous tumor (SFT) is a localized neoplasm characterized by proliferation of thin-walled vessels and collagen-producing cells and is considered within the "hemangiopericytoma-solitary fibrous tumor" spectrum.
  • A cellular, spindle cell neoplasm was arranged in loose fascicles, associated with heavy collagen fiber deposition.
  • These findings confirmed a diagnosis of extraplural solitary fibrous tumor.
  • CONCLUSIONS: The characteristic histologic pattern of solitary fibrous tumor can be noted in extrapulmonary locations.
  • Development in the larynx is uncommon, but the tumor presents as a polypoid mass with characteristic histologic and immunophenotypic features.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Disease-Free Survival. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20614325.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807554
  • [Keywords] NOTNLM ; Benign neoplasm / CD34 / Fibroma / Hemangiopericytoma / Immunohistochemistry / Larynx / Mesenchymal tumor / Prognosis / Solitary fibrous tumor / Spindle cell squamous cell carcinoma / Surgery / True vocal cord / bcl-2
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4. Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV: The clinical approach towards chondrosarcoma. Oncologist; 2008 Mar;13(3):320-9
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondrosarcomas that arise de novo are primary chondrosarcomas, whereas chondrosarcomas developing superimposed on pre-existing benign cartilage neoplasms such as enchondromas or osteochondromas are referred to as secondary chondrosarcomas.
  • [MeSH-major] Bone Neoplasms / therapy. Chondrosarcoma, Mesenchymal / therapy

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  • [ErratumIn] Oncologist. 2008 May;13(5):618
  • (PMID = 18378543.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 91
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5. Sohn SH, Koh SA, Kim DG, Park SW, Lee KH, Kim MK, Choi JH, Hyun MS: A case of spine origin chondroblastoma metastasis to lung. Cancer Res Treat; 2009 Dec;41(4):241-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastoma is a rare benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors and characteristically arises in the epiphysis of a long bone, particularly the humerus, tibia, and femur.
  • Unlike previously published examples of metastatic chondroblastoma, these metastasis developed before any operative manipulation of the primary tumor.
  • And primary tumor site was also unusual.

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  • (PMID = 20057972.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2802843
  • [Keywords] NOTNLM ; Chondroblastoma / Lung metastasis / Spine origin
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6. Budny AM, Ismail A, Osher L: Chondromyxoid fibroma. J Foot Ankle Surg; 2008 Mar-Apr;47(2):153-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is an uncommon benign cartilaginous tumor accounting for less than 1% of all bone tumors.

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  • (PMID = 18312923.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Veras EF, Santamaria IB, Luna MA: Sinonasal chondromyxoid fibroma. Ann Diagn Pathol; 2009 Feb;13(1):41-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor that usually arises from the metaphysis of long bones.
  • The initial radiographic findings were suggestive of a vascular tumor or a malignancy, but microscopic examination revealed the typical pathologic features of CMF, and SOX9 immunostaining confirmed its cartilaginous origin.
  • The tumor was successfully excised, and the patient was free of disease at 12-month follow-up.
  • [MeSH-major] Chondroma / pathology. Fibroma / pathology. Nasal Septum / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 19118781.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human
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8. Luevitoonvechkij S, Arphornchayanon O, Leerapun T, Khunsree S: Periosteal chondroma of the proximal humerus: a case report and review of the literature. J Med Assoc Thai; 2006 Nov;89(11):1970-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Periosteal chondroma is a slow growing benign cartilaginous tumor of bone.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Humerus

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  • (PMID = 17205883.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Number-of-references] 17
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9. Smith CA, Magenis RE, Himoe E, Smith C, Mansoor A: Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19. Cancer Genet Cytogenet; 2006 Dec;171(2):97-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is an uncommon benign cartilaginous tumor that rarely presents in the sino-nasal region as a locally destructive, erosive lesion.
  • Histology of the tumor, especially with a small sample, can be challenging because of its heterogeneous nature showing an admixture of fibrous, myxoid, and chondroid areas.
  • These results illustrate the distinctive nature of this tumor and may help identify genes involved in the pathogenesis of this tumor.
  • [MeSH-major] Chromosomes, Human, Pair 19. Chromosomes, Human, Pair 6. DNA Transposable Elements. Fibroma / genetics. Nasal Cavity. Nose Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 17116486.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Transposable Elements
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10. Sheff JS, Wang S: Extraskeletal osteochondroma of the foot. J Foot Ankle Surg; 2005 Jan-Feb;44(1):57-9
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  • An extraskeletal osteochondroma is an infrequently encountered benign cartilaginous tumor with a predilection for the hands and feet that usually does not exceed 3 cm in diameter.
  • This diagnosis can be misleading because it bears the same name as the osseous neoplasm more commonly referred to as an exostosis.
  • [MeSH-major] Foot Diseases / pathology. Osteochondroma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 15704084.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Kiralj A, Ilić M, Markov B, Dedić S, Pejaković B, Nalić B: [Chondroma of the skull base and maxilla]. Med Pregl; 2007 Nov-Dec;60(11-12):649-51
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  • INTRODUCTION: Chondromas are uncommon benign tumors of cartilaginous origin.
  • A chondroma is a painless, slow growing tumor causing destruction and exfoliation of teeth.
  • On a radiograph, the tumor appears as a cyst-like radiolucent lesion, while some are sclerotic.
  • DISCUSSION AND CONCLUSION: Chondromyxoid fibroma (CMF) is a rare, benign cartilaginous tumor that often occurs in the metaphyses of proximal tibia, proximal and distal femur and small bones of the foot.
  • The differential diagnosis is wide and includes simple or aneyrismal bone cyst, giant cell tumor, nonossifying fibroma, fibrous dysplasia, enchondroma, chondroblastoma, eosinophilic granuloma and fibrous cortical defect.
  • In the diagnosis of an intracranial chondrocytic tumor, it is important to distinguish it from enchondroma and chondrosarcoma.
  • [MeSH-major] Chondroma. Maxillary Neoplasms. Skull Base Neoplasms

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  • (PMID = 18666612.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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12. Stanić V, Vulović T, Stamenović D, Dordević G: Use of Marlex mesh with methylmethacrylate to repair large full-thickness defects after subtotal sternectomy caused by chondroma. Vojnosanit Pregl; 2008 Feb;65(2):175-7
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  • BACKGROUND: Sternal benign neoplasms are extremely rare.
  • Chondroma is a benign tumor of cartilage and can be single or multple.
  • CASE REPORT: We presented a case of 28-year-old woman with chondroma of the sternum treated by "en bloc" resection of the tumor (subtotal sternectomy).
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Methylmethacrylate. Polypropylenes. Sternum. Surgical Mesh. Thoracic Wall / surgery

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  • (PMID = 18365678.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Polypropylenes; 196OC77688 / Methylmethacrylate
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13. Alman BA, Wunder JS: Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia. Ann N Y Acad Sci; 2008 Nov;1144:36-41
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  • [Title] Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia.
  • By studying the interaction of the pathways in normal and neoplastic growth-plate chondrocytes (from enchondromas, a benign cartilage tumor), an unexpected direct regulation of hedgehog-mediated transcriptional activation by parathyroid hormone-related protein was uncovered.
  • [MeSH-major] Bone Development / genetics. Bone Neoplasms / metabolism. Cartilage / metabolism. Chondroma / metabolism. Chondrosarcoma / metabolism. Parathyroid Hormone-Related Protein / metabolism. Transcription Factors / metabolism. Transcriptional Activation

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  • (PMID = 19076361.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Parathyroid Hormone-Related Protein; 0 / Transcription Factors
  • [Number-of-references] 32
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14. Falcone G, Rossi ED, Maccauro G, de Santis V, Rosa MA, Capelli A, Fadda G: Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):334-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors.
  • The goal of this study was to evaluate the diagnostic relevance of the expression of growth factors in cartilaginous tumors and to investigate on the possible correlation with grade, local recurrence, metastatic potential, and survival.
  • Expression of VEGF, PDGF, FGF1, TFGbeta2, TNFalpha, Ki-67, and p53 was analyzed in 21 cases of benign and malignant cartilaginous tumors using immunohistochemistry.
  • These data suggest a progressive modification in the biologic behavior of malignant cartilaginous tumors.

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  • (PMID = 16932026.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Growth Substances
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15. Nagata S, Nishimura H, Uchida M, Hayabuchi N: [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors]. Nihon Igaku Hoshasen Gakkai Zasshi; 2005 Jan;65(1):30-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors].
  • PURPOSE: To evaluate the usefulness of diffusion-weighted MRI in distinguishing different components and in differentiating benign from malignant musculoskeletal tumors.
  • All tumors were classified into 8 groups (myxomatous, fibrous, cystic, cartilaginous, fatty components, hematomas, other benign tumors, and other malignant tumors).
  • RESULTS: ADC values of myxomatous, cystic, and cartilaginous components were significantly higher than those of other tumors.
  • In cartilaginous tumors, malignant tumor ADC values (2.33 +/- 0.44) were higher than those of benign tumors (2.13 +/- 0.13).
  • However, there was no significant difference between benign and malignant tumors.
  • Except for high-intensity components on T1-weighted imaging and low or homogeneously very high intensity components on T2-weighted imaging, there was a significant difference in ADC between malignant (1.35 +/- 0.40) and benign (1.97 +/- 0.50) tumors.
  • CONCLUSION: Within the limited number of cases, there was a significant difference in ADC between malignant and benign tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 15726897.001).
  • [ISSN] 0048-0428
  • [Journal-full-title] Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica
  • [ISO-abbreviation] Nihon Igaku Hoshasen Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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16. Châtillon CE, Guiot MC, Jacques L: Lipomatous, vascular, and chondromatous benign tumors of the peripheral nerves: representative cases and review of the literature. Neurosurg Focus; 2007;22(6):E18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous, vascular, and chondromatous benign tumors of the peripheral nerves: representative cases and review of the literature.
  • Benign peripheral nerve lesions of lipomatous, vascular, and chondromatous origin are very rare.
  • Only one previous case of brachial plexus involvement by such a tumor has been reported.
  • The three cases discussed include a 44-year-old woman with an intraneural lipoma of the right middle trunk, a 40-year-old woman with an intraneural hemangioma infiltrating the right posterior cord, and a newborn male with a predominantly cartilaginous hamartoma originating from the right C-5 nerve root.
  • The literature review yielded six previous cases of intraneural lipoma, approximately 50 cases of lipofibromatous hamartoma, 13 cases of intraneural hemangioma, and no previous case of cartilaginous hamartoma originating from a nerve.
  • To the authors' knowledge, this is the first reported case of a cartilaginous hamartoma infiltrating a peripheral nerve.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroblastoma / surgery. Hemangioma / surgery. Lipoma / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 17613209.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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17. Rodriguez FJ, Aubry MC, Tazelaar HD, Slezak J, Carney JA: Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. Am J Surg Pathol; 2007 Dec;31(12):1844-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma.
  • The Carney triad is the clinical association of gastric stromal sarcomas, pulmonary cartilaginous tumors, and extra-adrenal paragangliomas.
  • The pulmonary tumors are its second commonest component and have been misinterpreted clinically and pathologically as metastases from the gastric tumors and pulmonary cartilaginous hamartomas, respectively.
  • They have not been previously described in detail in the pathology literature or compared with pulmonary cartilaginous hamartomas.
  • Forty-two patients with pulmonary cartilaginous tumors as a component of Carney triad were identified.
  • Hematoxylin and eosin-stained sections of the neoplasms were evaluated for a series of histologic features.
  • A subgroup of 41 tumors from the latter was compared with those in a group of pulmonary cartilaginous hamartomas.
  • Their pulmonary neoplasm(s) were usually asymptomatic, often multiple, well circumscribed, medium-sized (mean diameter=2.8 cm), and composed almost exclusively of cartilage and bone surrounded by a fibrous pseudocapsule.
  • The cartilage was usually myxoid, less frequently hyaline, and commonly calcified, ossified, or both.
  • The pulmonary neoplasms in the Carney triad are well-differentiated benign cartilaginous tumors that are best designated as chondromas.
  • They differ pathologically from pulmonary cartilaginous hamartomas on the basis of the presence of a thin fibrous pseudocapsule, frequent bone metaplasia, and calcification, and also the absence of entrapped epithelium and fat.
  • [MeSH-major] Chondroma / pathology. Hamartoma / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18043038.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Hakan T, Vardar Aker F: Chondromyxoid fibroma of frontal bone: a case report and review of the literature. Turk Neurosurg; 2008 Jul;18(3):249-53

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  • Chondromyxoid fibroma is an unusual benign tumor of cartilaginous tissues that may be confused with other some malign tumors.
  • The patient underwent tumor excision with craniectomy, then acrylic cranioplasty.
  • In conclusion, chondromyxoid fibroma is a benign primary bone tumor that is located extremely rarely in the frontal bone.
  • En block surgical resection of the tumor is the cornerstone of treatment.
  • [MeSH-major] Chondroma / pathology. Fibroma / pathology. Frontal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 18814113.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 22
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19. El Samman K, Sedivý P, Syrůcek M, Sebesta P: Unusual groin resistance--a case study. Int Surg; 2010 Apr-Jun;95(2):117-9

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  • Extraskeletal osteochondroma is a benign, cartilaginous, slow-growing tumor with typical location near the joints of hands, feet, and knees.
  • [MeSH-major] Osteochondroma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20718316.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Choi YD, Kim SS, Lee JS, Nam JH, Choi C, Na KJ, Lee JH: Abundant cartilage formation of congenital pulmonary airway malformation--a case report. Pathol Res Pract; 2009;205(7):494-7
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  • [Title] Abundant cartilage formation of congenital pulmonary airway malformation--a case report.
  • We report an unusual case of type 1 CPAM with abundant cartilage in a 5-year-old boy.
  • On chest radiography, a left lung mass was detected incidentally, and tumor resection was performed under the impression of a benign tumor.
  • The pathological examination of the mass revealed abundant cartilage in the walls of malformed bronchioles with partially cystic dilatation.
  • We think that this case represents a cartilaginous variant of CPAM.
  • The cartilaginous variant of CPAM should be differentiated pathologically from other pulmonary neoplasms containing abundant cartilage, such as chondroid hamartoma.
  • [MeSH-major] Bronchioles / abnormalities. Cartilage / pathology. Incidental Findings. Lung Neoplasms / diagnosis. Respiratory System Abnormalities / pathology

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  • (PMID = 19231095.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Yalniz E, Alicioglu B, Yalcin O, Yilmaz B: Non specific magnetic resonance features of chondromyxoid fibroma of the iliac bone. J BUON; 2007 Jul-Sep;12(3):407-9
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  • Chondromyxoid fibroma is a benign cartilaginous neoplasm.
  • The tumor is rare, perhaps the rarest of all bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondroma / diagnosis. Fibroma / diagnosis. Ilium. Magnetic Resonance Imaging

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  • (PMID = 17918298.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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22. Rosa M, Bajestani S, Davis C, Makary R, Villas B: Fine-needle aspiration biopsy diagnosis of costal juxtacortical chondrosarcoma presenting as an abdominal mass. Diagn Cytopathol; 2010 Nov;38(11):837-40
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  • The majority of chondroid tumors arising in the cortex of bone are benign in nature.
  • Juxtacortical chondrosarcoma is a relatively uncommon variant of chondrosarcoma, which by definition, is a malignant cartilaginous tumor that occurs on the surface of bone and measures at least 5 cm.
  • [MeSH-major] Abdomen / pathology. Bone Neoplasms / pathology. Chondrosarcoma / pathology. Ribs / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187114.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Kishore B, Khare P, Gupta RJ, Gupta C, Khare V: Tumoral calcium pyrophosphate dihydrate crystal deposition disease: a rare diagnosis by fine-needle aspiration. Diagn Cytopathol; 2010 Jan;38(1):47-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical suspicion was that of malignant soft tissue tumor.
  • Tophaceous/ tumoral pseudogout is a rare form of CPPD and it is important to recognize that this form can be diagnosed in FNA cytology (FNAC) and misdiagnosis of benign or malignant cartilaginous lesions can be avoided.
  • [MeSH-major] Chondrocalcinosis / diagnosis. Chondrocalcinosis / pathology. Hand / pathology. Neoplasms / diagnosis. Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19688761.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Petsas T, Megas P, Papathanassiou Z: Radiofrequency ablation of two femoral head chondroblastomas. Eur J Radiol; 2007 Jul;63(1):63-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastoma is a rare benign cartilaginous bone tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Chondroblastoma / surgery. Femur Head / surgery

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  • (PMID = 17482405.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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25. Semenova LA, Bulycheva IV: [Chondromas (enchondroma, periosteal chondroma, enchondromatosis)]. Arkh Patol; 2007 Sep-Oct;69(5):45-8
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  • Chondromas combine a group of benign cartilaginous tissue tumors with common histological manifestations.
  • Chondromas are generally hypocellular, avascular tumors with an abundance of hyaline cartilage matrix and chondrocytes located diffusely, in clones or lobules.
  • Small bone chondromas, Ollier's disease, and Mafucci's syndrome are characterized by the tumor tissue containing a large number of cells and by greater cytological atypia.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrocytes / pathology. Chondroma / pathology. Enchondromatosis / pathology. Extracellular Matrix / pathology. Hyaline Cartilage / pathology

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  • (PMID = 18074822.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 30
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26. Yoo WH, Kim JR, Jang KY, Lee SY, Park JH: Rapidly developed huge bursitis associated with scapular osteochondroma of the multiple exostosis: a case report. Rheumatol Int; 2009 Jan;29(3):317-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor and present as multiple masses in the hereditary disorder of multiple hereditary exostosis.
  • However, it rarely causes symptoms such as mass effects that produce several mechanical problems, and malignant transformation of the cartilaginous cap.

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  • [Cites] Am J Clin Pathol. 1981 May;75(5):648-53 [7234751.001]
  • [Cites] Skeletal Radiol. 1991;20(7):513-6 [1754913.001]
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  • (PMID = 18682954.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Karkuzhali P, Chithralekha S, Muthuvel E, Daniel RB: Chondromyxoid fibroma of the parietal bone. Neuropathology; 2005 Mar;25(1):84-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is a benign cartilaginous neoplasm, which can be easily mistaken for chondrosarcoma, especially in small biopsies.
  • [MeSH-major] Chondroblastoma / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 15822822.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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28. Jundt G, Baumhoer D: [Cartilage tumors of the skeleton]. Pathologe; 2008 Nov;29 Suppl 2:223-31
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  • [Title] [Cartilage tumors of the skeleton].
  • Although the spectrum of benign and malignant cartilaginous bone tumors is extremely wide, a distinct diagnosis, even from small biopsy specimens, is almost always possible if radiological findings, age, clinical data, and localization within the skeleton as well as within the bone are considered.
  • With limitations, this also holds true for distinguishing enchondromas from low-grade chondrosarcomas; however, extensive experience in multidisciplinary bone tumor diagnosis is required.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Chondroma / pathology. Chondrosarcoma / pathology. Osteochondroma / pathology

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  • [Cites] Ann R Coll Surg Engl. 2003 Jul;85(4):272-6 [12855033.001]
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  • (PMID = 18820927.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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29. Mahesha V, Goyal R, Vaiphei K, Nada R, Gupta AK: Primary chondrosarcoma of ethmoid bone in a 6-year-old child. Ann Diagn Pathol; 2006 Jun;10(3):154-6
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  • Chondrosarcoma (CS) is a distinctly uncommon tumor in young patients and tends to be located in the extremities.
  • Cartilaginous tumors in young patients are benign tumors.
  • This case highlights the rarity of this tumor with regard to age of presentation and site of origin.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Ethmoid Bone / pathology

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  • (PMID = 16730310.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Stănescu L, Popescu CF, Niculescu CE, Dumitrescu D, Mogoantă SS, Georgescu I: Subungual exostosis of the big toe. Rom J Morphol Embryol; 2009;50(3):501-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The subungual exostosis is a benign bone tumor on the distal phalanx of a digit, beneath or adjacent to the nail, often bringing in discussion many differential diagnosis.
  • The local excision of the entire region with the removal of the cartilaginous cap has been followed by a silent period without recurrences of almost two years when he as revised.

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  • (PMID = 19690782.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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31. Röpke M, Boltze C, Meyer B, Neumann HW, Roessner A, Schneider-Stock R: Rb-loss is associated with high malignancy in chondrosarcoma. Oncol Rep; 2006 Jan;15(1):89-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied the loss of heterozygosity (LOH) of the Rb gene in 31 formalin-fixed, paraffin-embedded cartilaginous tumors using polymerase chain reaction.
  • The only case of DD chondrosarcoma negative for Rb-LOH in both components of the tumor also showed weak expression of the Rb protein in the anaplastic component.
  • All benign cartilaginous tumors, low-grade chondrosarcomas and low-grade tumor components of DD chondrosarcomas were negative regarding Rb-LOH but positive in Rb immunohistostaining.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Genes, Retinoblastoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retinoblastoma Protein / analysis. Retinoblastoma Protein / genetics

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  • (PMID = 16328039.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Retinoblastoma Protein
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32. Vialle R, Feydy A, Rillardon L, Tohme-Noun C, Anract P, Colombat M, De Pinieux G, Drapé JL, Guigui P: Chondroblastoma of the lumbar spine. Report of two cases and review of the literature. J Neurosurg Spine; 2005 May;2(5):596-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastoma is a benign cartilaginous neoplasm that generally affects the appendicular skeleton.
  • Magnetic resonance imaging allowed the authors to study the tumor's local extension.
  • [MeSH-major] Chondroblastoma / pathology. Chondroblastoma / surgery. Spinal Fusion. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Low Back Pain / etiology. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 15945435.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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33. Schmidt GP, Reiser MF, Baur-Melnyk A: Whole-body imaging of bone marrow. Semin Musculoskelet Radiol; 2009 Jun;13(2):120-33
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  • Hybrid imaging concepts, such as positron emission tomography-computed tomography (PET-CT) scan, have been established as an effective tool for the detection of skeletal metastases, using the additional metabolic information of a PET scan for the assessment of tumor viability and therapy response.
  • Furthermore it can depict tumor expansion into adjacent paraosseous structures, such as the spinal canal.
  • Furthermore, it has recently been proposed for the assessment of primarily benign bone diseases predisposing for malignancy (e.g., multiple cartilaginous exostoses).
  • [MeSH-minor] Aged. Algorithms. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Child. Histiocytosis, Langerhans-Cell / pathology. Humans. Lymphoma / pathology. Multiple Myeloma / pathology. Positron-Emission Tomography. Young Adult

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  • (PMID = 19455475.001).
  • [ISSN] 1098-898X
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Donthineni R, Ofluoğlu O: Solitary enchondromas of long bones: pattern of referral and outcome. Acta Orthop Traumatol Turc; 2010;44(5):397-402
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  • OBJECTIVES: Enchondromas are benign cartilaginous tumors, often found incidentally and diagnosed by the radiographic appearance.
  • Very few had the classic signs of an aggressive/growing cartilage tumor.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondroma / diagnosis. Femur. Humerus. Referral and Consultation

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  • (PMID = 21343691.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Turkey
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35. Sbai MA, Hamdi MF, Aloui I, Zalouni I, Tabib M: [Soft tissue chondroma of the thumb. A case report]. Tunis Med; 2010 Oct;88(10):750-2
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  • [Transliterated title] Le chondrome des parties molles du pouce. A propos d'un cas.
  • BACKGROUND: Soft-tissue chondroma is a rare and benign cartilaginous tumour often localised in the extremities.
  • CONCLUSION: Soft tissue chondroma is not a diagnosis evoked when we have a soft tissue tumor of the hand.
  • [MeSH-major] Chondroma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thumb

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  • (PMID = 20890825.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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36. Oliveira RC, Marques KD, Mendonça AR, Mendonça EF, Silva MR, Batista AC, Ribeiro-Rotta RF: Chondrosarcoma of the temporomandibular joint: a case report in a child. J Orofac Pain; 2009;23(3):275-81
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  • Chondrosarcoma is a malignant cartilaginous neoplasm that resembles synovial chondromatosis.
  • Microscopic findings showed a tumor exhibiting cartilaginous tissue proliferation with cellular pleomorphism, nuclear hyperchromasia, and mixoid changes in the matrix.
  • It is concluded that cartilaginous lesions in the jaws must be regarded with suspicion, since benign and malignant lesions may show similar clinical features.

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  • (PMID = 19639107.001).
  • [ISSN] 1064-6655
  • [Journal-full-title] Journal of orofacial pain
  • [ISO-abbreviation] J Orofac Pain
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCNB1 protein, human; 0 / Cyclin B; 0 / Cyclin B1; 0 / Ki-67 Antigen
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37. Sando N, Oka K, Moriya T, Saito H, Nagakura S, Mori N, Suzuki T, Ueki H, Ohtani H: Osteosarcoma arising in the breast. APMIS; 2006 Jul-Aug;114(7-8):581-7
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  • The tumors were diagnosed as a fibroadenoma and a benign phyllodes tumor, respectively.
  • The tumor occupied the entire breast and measured 12x9x8.5 cm.
  • The tumor cells were spindle-shaped and pleomorphic, with large, irregular nuclei and distinct nucleoli.
  • Many tumor cells had characteristics of osteoblastic and chondroblastic elements producing osteoid, osseous, and cartilaginous intracellular substances.
  • Tumor cells expressed vimentin, osteopontin, vascular endothelial growth factor, CD10, and alkaline phosphatase, but did not express keratin.
  • [MeSH-major] Breast Neoplasms / pathology. Osteosarcoma / pathology

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  • (PMID = 16907866.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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38. Fernández-Aguilar S, Noël JC: [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report]. Ann Pathol; 2007 Feb;27(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report].
  • [Transliterated title] Tumeur phyllode maligne du sein avec cellules géantes de type ostéoclastique: à propos d'un cas.
  • We report here the first case of a malignant phyllodes tumor associated with OLGC occurring in a 43 year-old African woman who presented with a painful palpable mass of the outer upper quadrant of the right breast.
  • After surgical excision, histological examination showed a malignant phyllodes tumor in which the stromal component displayed evident sarcomatous changes and was densely populated with benign multinucleated OLGC.
  • No evidence of osseous or cartilaginous differentiation was seen throughout the lesion.
  • This lesion ressembles giant cell tumor of bone.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology. Phyllodes Tumor / pathology

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  • (PMID = 17568357.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Schrage YM, Machado I, Meijer D, Briaire-de Bruijn I, van den Akker BE, Taminiau AH, Kalinski T, Llombart-Bosch A, Bovée JV: COX-2 expression in chondrosarcoma: a role for celecoxib treatment? Eur J Cancer; 2010 Feb;46(3):616-24
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  • A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis.
  • COX-2 expression was studied in central- and peripheral cartilaginous tumours.
  • Also the role of high-dose prophylactic celecoxib in preventing the development of benign and malignant cartilage tumours in EC and MO patients deserves further investigation.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Neoplasms / enzymology. Chondrosarcoma / enzymology. Cyclooxygenase 2 / metabolism. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use
  • [MeSH-minor] Animals. Celecoxib. Cell Survival / drug effects. Cyclooxygenase 2 Inhibitors / blood. Cyclooxygenase 2 Inhibitors / therapeutic use. Disease Models, Animal. Drug Evaluation, Preclinical / methods. Humans. Male. Mice. Mice, Nude. Tumor Cells, Cultured. Xenograft Model Antitumor Assays

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20004565.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; EC 1.14.99.1 / Cyclooxygenase 2; JCX84Q7J1L / Celecoxib
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40. Carrera JE, Castillo PA, Molina OM: [Lumbar osteochondroma and radicular compression. A case report]. Acta Ortop Mex; 2007 Sep-Oct;21(5):261-6
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  • [Transliterated title] Osteocondroma de lámina lumbar y compresión radicular. Reporte de un caso.
  • Most cartilage forming tumors are benign and rarely affect the spinal canal, their principal location is in humerus metaphysis, femur and tibia.
  • They represent 2% of all tumors and 2.6% of the benign tumors of the spine, usually located at the cervical spine.
  • It is speculated that the secondary ossification center may be aberrant cartilaginous tissue that causes the formation of osteochondroma.
  • It was performed: total removal of the tumor effectively and symptoms disappeared.
  • [MeSH-major] Lumbar Vertebrae / surgery. Nerve Compression Syndromes / etiology. Osteochondroma / complications. Spinal Cord Compression / etiology. Spinal Neoplasms / complications. Spinal Nerve Roots

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  • (PMID = 18159915.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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41. Sepah YJ, Umer M, Minhas K, Hafeez K: Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report. J Med Case Rep; 2007;1:135
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  • We report the case of a young adult who presented with a painful foot due to chondroblastoma associated with an aneurismal bone cyst.Chondroblastoma is a rare benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors and characteristically arises in the epiphysis of a long bone, particularly the humerus, tibia, and femur.

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  • [Cites] J Bone Joint Surg Am. 1985 Jun;67(5):748-55 [3997927.001]
  • [Cites] Clin Orthop Relat Res. 1973 Sep;(95):300-12 [4585180.001]
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  • [Cites] Foot Ankle Int. 1997 Apr;18(4):236-42 [9127115.001]
  • (PMID = 17999776.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2194702
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42. Randall RL, Gowski W: Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma. J Natl Compr Canc Netw; 2005 Mar;3(2):149-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cartilaginous lesions of bone are relatively common and cover a large spectrum from latent enchondroma to aggressive dedifferentiated chondrosarcoma.
  • Differentiating among these lesions, particularly benign enchondroma and low-grade chondrosarcoma, can be challenging.
  • This review highlights the specific clinical, radiographic, and histologic criteria currently used clinically to differentiate between benign enchondroma and low-grade chondrosarcoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Chondrosarcoma / diagnosis. Chondrosarcoma / therapy

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  • (PMID = 19817027.001).
  • [ISSN] 1540-1405
  • [Journal-full-title] Journal of the National Comprehensive Cancer Network : JNCCN
  • [ISO-abbreviation] J Natl Compr Canc Netw
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Number-of-references] 34
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43. Kanngurn S, Somran J, Art-Ong C, Lamlertthon W, Porncharoenpong S: Primary peritoneal adenosarcoma with stromal overgrowth and fetal type cartilage: a case report and literature review. J Med Assoc Thai; 2005 Jun;88(6):849-54

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  • [Title] Primary peritoneal adenosarcoma with stromal overgrowth and fetal type cartilage: a case report and literature review.
  • Primary peritoneal adenosarcoma with sarcomatous overgrowth and fetal-type cartilage presented in a 48-year-old female patient is described.
  • The tumor seems likely to have derived from the pelvic peritoneum, wheareas the uterus, ovaries and tubes were uninvolved.
  • It was composed of benign-appearing glands and a sarcomatous component showing cartilaginous differentiation.
  • [MeSH-major] Adenosarcoma / pathology. Cartilage / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 16083229.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Number-of-references] 22
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44. Hatori M, Watanabe M, Kotake H, Kokubun S: Chondrosarcoma of the ring finger: a case report and review of the literature. Tohoku J Exp Med; 2006 Mar;208(3):275-81
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  • Enchondromas are the most common benign cartilaginous bone tumors arising in the medullary cavity of the small bones of the hand.
  • The findings of cortical irregular thickening by plain radiography and computed tomography and soft tissue extension by magnetic resonance imaging suggested the tumor was chondrosarcoma rather than a common enchondroma.
  • Histological examination revealed that the tumor was composed of polygonal cells with eosinophilic cytoplasm proliferating in the chondromatous matrix with partially myxoid changes.
  • Nuclear irregularity, binucleated cells, bone permeation and encasement were observed and the tumor was diagnosed as grade 2 chondrosarcoma.
  • The tumor recurred five months after surgery.
  • In conclusion, details of radiological as well as pathological findings are essential for differential diagnosis between benign enchondroma and chondrosarcoma in the hand.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Fingers / pathology. Review Literature as Topic
  • [MeSH-minor] Aged, 80 and over. Chondroma / diagnosis. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16498237.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Kim WJ, Kim KJ, Lee SK, Choy WS: Solitary pelvic osteochondroma causing L5 nerve root compression. Orthopedics; 2009 Dec;32(12):922
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors.
  • Thus, surgical excision is not routinely recommended unless the tumor causes clinical symptoms or cosmetic distress.
  • An exostotic bony projection composed of dense calcification of the cartilaginous cap arose from the iliac crest, which was located just lateral to the right sacroiliac joint in the paravertebral area, L5 level.
  • Magnetic resonance imaging showed an irregular, exophytic outgrowing calcified mass with cartilage cap and exostotic mass compressed to the proximal part of the right L5 nerve root lateral to the nerve root foramen.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / surgery. Decompression, Surgical / methods. Osteochondroma / complications. Osteochondroma / surgery. Pelvic Bones / radiography. Pelvic Bones / surgery. Radiculopathy / etiology. Radiculopathy / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968229.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Slotcavage RL, Dickson BC, Ogilvie CM: Chondromyxoid fibroma involving the metacarpophalangeal joint. Orthopedics; 2009 Apr;32(4)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is a rare benign bony tumor classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and small foot bones.
  • The tumor is considered a physeal plate remnant and may involve the epiphysis, diaphysis, or both along with its metaphyseal origin.
  • Open biopsy revealed calcified cartilaginous synovial deposits suspicious for synovial chondromatosis, with erosion into surrounding bones.
  • This benign, curable lesion should be included in the differential diagnosis of a bony lesion, even when a joint and adjacent bones are involved.
  • [MeSH-major] Bone Neoplasms / radiography. Chondroma / radiography. Fibroma / radiography. Metacarpophalangeal Joint / radiography

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  • (PMID = 19388607.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. van den Berg H, Slaar A, Kroon HM, Taminiau AH, Hogendoorn P: Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Pediatr Orthop; 2008 Jul-Aug;28(5):561-4
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  • PROCEDURE: All 262 bone tumor specimens of children up to the age of 19 years reviewed from 1999 to 2003 by the Netherlands Committee on Bone Tumors were included.
  • Seven of 198 benign lesions were reclassified as malignant.
  • Kappa values were indicative for good agreement in the (by the Ministry of Health designated) bone tumor centers.
  • For cartilaginous, osteogenic, and fibrous tumors, agreement was lower.
  • Adamantinomas were not recognized in non-bone tumor centers.
  • Specifically in non-bone tumor centers, the correctness of the initial diagnosis can be questioned.
  • [MeSH-major] Bone Neoplasms / pathology

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  • (PMID = 18580373.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Almeida G, Silveira F, do Val I, Correa A: Extraosseous vulvar chondroma: a case report. J Reprod Med; 2007 Jan;52(1):35-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Extraosseous chondromas are cartilaginous tissue tumors with a nodular appearance on the hands and feet.
  • Treatment is by surgery and requires removing the tumor with a safety margin.
  • CASE: An 11-year-old girl was referred for a painless solid tumor located on the mons pubis.
  • Surgical removal of the tumor with a safety margin was performed.
  • Macroscopically, the tumor was shiny when cut open and yellowish.
  • Microscopic examination revealed a very distinct cartilage-forming tumor compatible with extraosseous chondroma.
  • CONCLUSION: Extraosseous chondroma is a rare benign tumor.
  • This appears to be the first such report of this type of tumor in this region and age range.

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  • (PMID = 17286066.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Ohtsuka H: Chondrolipoma of the popliteal fossa and Japanese reports. J Dermatol; 2006 Mar;33(3):202-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eleven patients with chondrolipoma including lipoma with cartilaginous metaplasia, including my case, have been reported in Japan.
  • The presented tumor was an early one because of the shortest duration and the smallest size in Japan.
  • Recent criteria for a benign mesenchymoma including a chondrolipoma were also described.
  • [MeSH-major] Chondroma / pathology. Knee. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16620227.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 18
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50. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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51. Stieber JR, Dormans JP: Manifestations of hereditary multiple exostoses. J Am Acad Orthop Surg; 2005 Mar-Apr;13(2):110-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The solitary osteochondroma, a common pediatric bone tumor, is a cartilage-capped exostosis.
  • Although exostoses are benign lesions, they are often associated with characteristic progressive skeletal deformities and may cause clinical symptoms.
  • Patients with hereditary multiple exostosis have a slight risk of sarcomatous transformation of the cartilaginous portion of the exostosis.


52. Znati K, Ahaouch M, Fatemi H, Chbani L, Affifi A, Kamaoui I, Bennis S, Amarti A: [Femoral metaphyso-diaphyseal chondroblastoma: a case report]. Rev Chir Orthop Reparatrice Appar Mot; 2007 May;93(3):283-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Chondroblastome métaphyso-diaphysaire du fémur: à propos d'un cas.
  • Chondroblastoma is a rare benign tumor of cartilage tissue accounting for less than 1% of all bone tumors.
  • We discuss the anatomic aspects and the clinical course of this rare tumor and present current knowledge of the histogenesis.
  • [MeSH-major] Chondroblastoma / diagnosis. Femoral Neoplasms / diagnosis

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  • (PMID = 17534212.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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53. Singh H, Meyer SA, Jenkins AL 3rd: Treatment of primary vertebral tumors. Mt Sinai J Med; 2009 Oct;76(5):499-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These lesions encompass a wide variety of tumor types classified by their cell of origin: bony tumors, cartilaginous tumors, vascular tumors, plasma cell dyscrasias, and tumors that arise from embryonic rests.
  • Further classification of these tumors into malignant or benign subtypes is based on their clinical progression, histopathological evidence of invasiveness, and response to therapy.
  • We provide a brief overview and description of primary tumors as well as treatment paradigms for the individual tumor types.
  • [MeSH-major] Spinal Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasms / surgery. Paraproteinemias. Vascular Neoplasms / pathology. Vascular Neoplasms / surgery

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  • (PMID = 19787656.001).
  • [ISSN] 1931-7581
  • [Journal-full-title] The Mount Sinai journal of medicine, New York
  • [ISO-abbreviation] Mt. Sinai J. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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54. Bulycheva IV, Semenov LA, Makhson AN, Zhukov AG: [Chondroblastoma]. Arkh Patol; 2007 May-Jun;69(3):53-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastom, benign cartilage tissue neoplasm, accounts for 1% of all bone tumors.
  • Cartilaginous portions of chondroblastoma form lobular structures.
  • The tumor always comprises single-to-multiple multinucleate giant cells.
  • [MeSH-major] Bone Neoplasms / radiography. Bone Neoplasms / therapy. Chondroblastoma / radiography. Chondroblastoma / therapy

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  • (PMID = 17722601.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Lectures
  • [Publication-country] Russia (Federation)
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55. Yang SW, Lin CY: A peculiar site of chondroma: the epiglottis. Acta Otolaryngol; 2005 Aug;125(8):906-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroma of the laryngeal cartilage is an uncommon benign cartilaginous neoplasm.
  • The commonest location is the posterior lamina of the cricoid cartilage, followed by the thyroid cartilage.
  • We present this case to highlight the occurrence of this rare benign lesion in the epiglottis, and stress that it should not be neglected in the differential diagnosis of an epiglottic mass.
  • [MeSH-major] Chondroma / diagnosis. Epiglottis / surgery. Laryngeal Neoplasms / diagnosis

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  • (PMID = 16158541.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 11
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