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1. Schell AJ, Xu Y, Baetz T, Harrison K, Ropchan G, LeBrun D, Feilotter H: Primary cardiac lymphoma: molecular cytogenetic characterization of a rare entity. Cardiovasc Pathol; 2009 Mar-Apr;18(2):92-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac lymphoma: molecular cytogenetic characterization of a rare entity.
  • BACKGROUND: The majority of cardiac atrial neoplasms represent benign myxomas.
  • Rarely, malignant cardiac neoplasms are encountered and can include primary cardiac neoplasms, as well as secondary tumors involving the heart.
  • As many cardiac neoplasms lack pathognomonic clinical features, histopathologic diagnosis is crucial for classification and appropriate treatment of these neoplasms.
  • A diagnosis of primary cardiac diffuse large B-cell lymphoma with plasmacytoid differentiation was established and was supported by cytogenetic studies demonstrating the presence of a t(14;18)(q32;q21) translocation in addition to other chromosomal abnormalities.
  • [MeSH-major] Chromosome Aberrations. Comparative Genomic Hybridization. Heart Neoplasms / genetics. In Situ Hybridization, Fluorescence / methods. Lymphoma / genetics
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 18. DNA, Neoplasm / analysis. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Translocation, Genetic

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  • (PMID = 18402841.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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2. Nuri MM, Naseem A, Raza A, Ahmad W, Raja MK, Ahmad A, Rasheed A, Gohar A: Right ventricular myxoma with heart failure. J Coll Physicians Surg Pak; 2005 Mar;15(3):184-6
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  • [Title] Right ventricular myxoma with heart failure.
  • Cardiac myxomas are histologically benign tumors but they may be lethal because of their strategic position.
  • We report a case of a large right ventricular myxoma presenting with heart failure.
  • [MeSH-major] Heart Failure / diagnosis. Heart Neoplasms / diagnosis. Heart Neoplasms / surgery. Mitral Valve Insufficiency / surgery. Myxoma / diagnosis. Myxoma / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Cardiac Surgical Procedures / methods. Echocardiography, Transesophageal. Follow-Up Studies. Heart Valve Prosthesis. Heart Ventricles. Humans. Immunohistochemistry. Male. Neoplasm Staging. Pakistan. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15808106.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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3. Carpino F, Pezzoli F, Petrozza V, Carpino G, Evangelista A, Mutone D, Reali M, Gaudio C: Angiosarcoma of the heart: structural and ultrastructural study. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):231-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the heart: structural and ultrastructural study.
  • BACKGROUND: Primary cardiac tumours are rare.
  • Nearly 70% of primary cardiac tumours are benign, the majority of which are represented by myxomas.
  • The most frequent primary cardiac neoplasm is the angiosarcoma that represents 31% of primary cardiac malignant.
  • We report a particular clinical case of cardiac angiosarcoma, its light and transmission electron microscopic aspects and a review of the recent literature.
  • METHODS: A 52 years old man died for a severe right ventricle filling deficit caused by an intracavitary tumour originated from the right atrial anterolateral wall.
  • The fragments obtained from autoptic tumoral cardiac tissue were processed for light and electron microscopy.
  • Results of Ulex Europeaeus Agglutinin I labelling were positive in both solid and vascular areas of the tumour although the positive reaction was less evident in the solid zones Factor VIII related antigen positive cells were less numerous and mainly found in vascular areas.
  • CONCLUSION: The light microscopy observation and immunohistochemical study underscore that is not easy to obtain information about the level of differentiation of this tumour.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangiosarcoma / pathology

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  • (PMID = 16128044.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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4. Maxey TS, Grow P, Morris CD, Patton KT, Guyton RA: Biatrial primary cardiac paraganglioma: a rare finding. Cardiovasc Pathol; 2007 May-Jun;16(3):179-82
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  • [Title] Biatrial primary cardiac paraganglioma: a rare finding.
  • The majority of primary cardiac tumors are benign; of these tumors, cardiac paragangliomas are among the rarest.
  • We report a case of biatrial cardiac paraganglioma discovered during workup for palpitations and fatigue.
  • The tumor involved the interatrial septum, with a lobulated portion protruding through the foramen ovale into the right atrium.
  • The tumor was successfully excised, leading to uneventful recovery.
  • [MeSH-major] Heart Neoplasms / pathology. Paraganglioma / pathology
  • [MeSH-minor] Adult. Echocardiography, Transesophageal. Heart Atria / pathology. Heart Atria / surgery. Heart Septum / pathology. Heart Septum / surgery. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17502248.001).
  • [ISSN] 1054-8807
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Begić H, Placci A, Picchio FM, Gargiulo G, Ibrahimović J: Papillary fibroelastoma of the mitral valve in an 8-month-old infant. Eur J Pediatr; 2008 Jun;167(6):685-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Papillary fibroelastomas, the third most common primary cardiac tumor in adults, are extremely rare in children.
  • These tumors grow slowly and are histologically benign but with high potential for life-threatening complications.
  • [MeSH-major] Echocardiography, Transesophageal. Fibroma / diagnostic imaging. Heart Neoplasms / diagnostic imaging. Mitral Valve / diagnostic imaging
  • [MeSH-minor] Diagnosis, Differential. Female. Heart Valve Diseases / diagnostic imaging. Heart Valve Diseases / surgery. Humans. Infant

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  • [Cites] Pediatr Cardiol. 1996 May-Jun;17 (3):194-5 [8662036.001]
  • [Cites] Ann Thorac Surg. 1997 Nov;64(5):1482-4 [9386734.001]
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  • (PMID = 17582532.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Kirschner LS, Kusewitt DF, Matyakhina L, Towns WH 2nd, Carney JA, Westphal H, Stratakis CA: A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res; 2005 Jun 1;65(11):4506-14
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  • [Title] A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.
  • Carney complex is an autosomal dominant neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and schwannomas.
  • To better understand the mechanism by which PRKAR1A mutations cause disease, we have developed conventional and conditional null alleles for Prkar1a in the mouse.
  • Although genotype-specific cardiac and adrenal lesions were not seen, benign and malignant thyroid neoplasias were observed in older mice.
  • This spectrum of tumors overlaps that seen in Carney complex patients, confirming the validity of this mouse model.
  • Genetic analysis indicated that allelic loss occurred in a subset of tumor cells, suggesting that complete loss of Prkar1a plays a key role in tumorigenesis.
  • These observations confirm the identity of PRKAR1A as a tumor suppressor gene with specific importance to cyclic AMP-responsive tissues and suggest that these mice may be valuable tools not only for understanding endocrine tumorigenesis but also for understanding inherited predispositions for schwannoma formation.
  • [MeSH-major] Cyclic AMP / physiology. Disease Models, Animal. Multiple Endocrine Neoplasia / genetics. Neurilemmoma / genetics. Proteins / genetics
  • [MeSH-minor] Alleles. Animals. Bone Neoplasms / enzymology. Bone Neoplasms / genetics. Bone Neoplasms / pathology. Cyclic AMP-Dependent Protein Kinase RIalpha Subunit. Female. Genes, Tumor Suppressor. Genetic Predisposition to Disease. Male. Mice. Osteoblasts / cytology. Osteoblasts / physiology. Schwann Cells / cytology. Schwann Cells / physiology. Syndrome. Thymus Gland / cytology. Thymus Gland / physiology. Thyroid Neoplasms / enzymology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 15930266.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16058; United States / NICHD NIH HHS / HD / HD01323
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / Prkar1a protein, mouse; 0 / Proteins; E0399OZS9N / Cyclic AMP
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7. Li L, Wang HY, Zhao H, Ruan YM, Lü FY, Wang QZ, Meng Y, Liu L: [Clinicopathologic studies of 11 cases of primary cardiac valve tumors]. Zhonghua Bing Li Xue Za Zhi; 2006 Mar;35(3):142-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic studies of 11 cases of primary cardiac valve tumors].
  • OBJECTIVE: To study the clinicopathologic features of primary cardiac valve tumors.
  • METHODS: Eleven cases of primary valve tumors collected from Fuwai Hospital during the period from 1983 to 2005 were enrolled into the study.
  • The tumors were stained with hematoxylin and eosin and Weigert-Van Gieson stain.
  • RESULTS: Primary cardiac valve tumors were uncommon and accounted for only 3% (11/426) of all primary cardiac tumors.
  • Most of them (10/11) were benign and malignancy was rarely encountered (1/11).
  • The tumor subtypes included papillary fibroelastoma (4/11), cavernous hemangioma (4/11), glomus tumor (1/11), angiosarcoma (1/11) and hamartoma (1/11).
  • Of the 11 tumors studied, 4 involved the tricuspid valve, 4 involved the mitral valve, 2 involved the pulmonary valve and 1 involved the aortic valve.
  • The diagnosis was established by preoperative echocardiography in 7 patients.
  • CONCLUSIONS: Preoperative diagnosis of primary cardiac valve tumors can be difficult due to lack of detailed information related to this group of lesions.
  • Although benign cardiac valve tumors carry a good prognosis, the clinical outcome may be disastrous as a result of hemodynamic disturbances.
  • [MeSH-major] Fibroma / pathology. Heart Neoplasms / pathology. Heart Valves / pathology. Hemangioma, Cavernous / pathology

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  • (PMID = 16630501.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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8. Georghiou GP, Vidne BA, Sahar G, Sharoni E, Fuks A, Porat E: Primary cardiac valve tumors. Asian Cardiovasc Thorac Ann; 2010 Jun;18(3):226-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac valve tumors.
  • To assess the prevalence, characteristics, and outcome of surgical treatment of primary cardiac valve tumors in a single center, we reviewed our experience in 6 women and 1 man, aged 49 to 76 years (mean, 64.7 years) who presented between 1999 and 2006.
  • In one patient, the diagnosis of cardiac valve tumor was made incidentally on transesophageal echocardiography during aortocoronary bypass surgery.
  • The others had clinical symptoms: angina or myocardial infarction in 3, congestive heart failure in 2, dyspnea and cerebrovascular ischemia in 1 patient each.
  • Four of the 7 tumors were benign, and 3 were malignant.
  • Two patients with malignant tumors were considered unsuitable for adjuvant therapy by the oncologist; both died during follow-up from local tumor recurrence.
  • Excellent early and midterm surgical results can be obtained in patients with benign cardiac valve tumors, but the prognosis for those with a malignant tumor is poor.
  • [MeSH-major] Heart Neoplasms. Heart Valves
  • [MeSH-minor] Aged. Cardiac Surgical Procedures. Echocardiography, Transesophageal. Exercise Tolerance. Female. Humans. Immunohistochemistry. Israel / epidemiology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local. Prevalence. Recovery of Function. Time Factors. Treatment Outcome

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  • (PMID = 20519288.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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9. Fan D, Yarnall C, Parmet JL, Norris RB, Isidro AB, Maher MB, Bridges CR: Resection of a large atrial hemangioma using a bloodless surgical technique: a case report. Heart Surg Forum; 2007;10(1):E87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hemangioma is extremely rare, accounting for 1% to 2% of benign cardiac tumors.
  • [MeSH-major] Heart Neoplasms / surgery. Hemangioma / surgery. Jehovah's Witnesses. Minimally Invasive Surgical Procedures / methods. Vascular Surgical Procedures / methods
  • [MeSH-minor] Aged. Female. Heart Atria / surgery. Humans. Treatment Outcome

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  • (PMID = 17311773.001).
  • [ISSN] 1522-6662
  • [Journal-full-title] The heart surgery forum
  • [ISO-abbreviation] Heart Surg Forum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Vaideeswar P, Butany JW: Benign cardiac tumors of the pluripotent mesenchyme. Semin Diagn Pathol; 2008 Feb;25(1):20-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign cardiac tumors of the pluripotent mesenchyme.
  • Among benign primary cardiac tumors, myxomas and papillary fibroelastomas are the most common.
  • Cardiac myxomas arise from pluripotent mesenchymal cells and are seen as intracardiac, glistening polypoid masses arising most frequently from the interatrial septum in the left atrium.
  • These tumors can be sporadic or familial.
  • Embolism is often the mode of presentation for both of the tumors; myxomas are also associated with obstructive and constitutional symptoms.
  • In contrast, neurogenic tumors (paraganglia or nerve sheath tumors) are exceedingly rare and occur as epicardial and infrequently as intracatdiac masses.
  • The tumors are often incidentally diagnosed by the usual echocardiography, but magnetic resonance imaging is useful for further characterization of the tumors.
  • The tumors are, in general, treated by surgical resection, but may require a little or at times more significant reconstruction.
  • Among these tumors, the myxomas are associated with a higher rate of recurrences.
  • [MeSH-major] Heart Neoplasms. Mesoderm / pathology. Myxoma. Neoplasms, Fibroepithelial. Pluripotent Stem Cells / pathology

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  • (PMID = 18350919.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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11. Roschkov S, Rebeyka D, Mah J, Urquhart G: The dangers of cardiac myxomas. Prog Cardiovasc Nurs; 2007;22(1):27-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The dangers of cardiac myxomas.
  • A variety of cardiac tumors have been acknowledged in the literature since the 16th century as rare forms of cardiac disease.
  • Of the primary tumors, myxomas account for at least 30% to 50% of benign tumors.
  • Despite significant advances in cardiac diagnostics leading to early recognition of myxomas, the potential for deleterious effects secondary to embolic complications remains high.
  • The purpose of this paper is to provide nurses with an understanding of the epidemiology, pathology, clinical presentation, and assessment of individuals with cardiac myxomas.
  • A case presentation is used to illustrate how the misdiagnosis of cardiac myxoma led to a delay in patient treatment.
  • Prompt recognition, diagnosis, and treatment are important in improving patient outcomes and quality of life.
  • Due to the infrequency of cardiac myxomas, ensuring appropriate preoperative and postoperative nursing care to the patient with a cardiac myxoma is essential.
  • [MeSH-major] Heart Neoplasms. Myxoma. Perioperative Care
  • [MeSH-minor] Early Diagnosis. Echocardiography. Heart Sounds. Humans. Male. Middle Aged. Neoplastic Cells, Circulating. Nurse's Role. Nursing Assessment. Nursing Diagnosis. Patient Care Planning. Prognosis. Quality of Life. Treatment Outcome

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  • (PMID = 17342003.001).
  • [ISSN] 0889-7204
  • [Journal-full-title] Progress in cardiovascular nursing
  • [ISO-abbreviation] Prog Cardiovasc Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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12. Figueroa-Torres Y, Martínez-Ojeda JA, Franqui-Rivera H, Martínez-Toro J: Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean. P R Health Sci J; 2008 Dec;27(4):373-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean.
  • INTRODUCTION: Neoplasms of the heart are extremely rare and difficult to diagnose.
  • In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms.
  • A total of 77 cases with a diagnosis of Benign Heart Neoplasm were found from 1992 to 2008 but only those with an official pathologic report (n = 43) were considered.
  • For interpretation of results, a p-value < 0.05 was considered significant.
  • RESULTS: The mean age for diagnosis was 51.49 years.
  • The most common presenting symptom by which these patients sought medical attention was congestive heart failure (35%), followed by chest pain (18%) and neurologic symptoms (14%).
  • The most common location of the mass was the left atrium (81%) and overall, the most common heart neoplasm in this study was myxoma (83.7%).
  • CONCLUSIONS: This study of a total of 43 pathologically confirmed benign cardiac neoplasms admitted to the Cardiovascular Center of Puerto Rico and the Caribbean from 1992 to 2008 validates the fact that heart neoplasms represent a fairly rare diagnosis.
  • It is also consistent with previously published series that establish myxoma as the most common of these benign neoplasms.
  • [MeSH-major] Heart Neoplasms / diagnosis

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  • (PMID = 19069370.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
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13. Kim RW, Jeffery ME, Smith MJ, Wilensky RL, Woo EY, Woo YJ: Minimally invasive resection of papillary fibroelastoma in a high-risk patient. J Cardiovasc Med (Hagerstown); 2007 Aug;8(8):639-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Papillary fibroelastomas are rare, benign cardiac tumors that typically mandate surgical resection.
  • We describe the minimally invasive resection of a right atrial fibroelastoma performed on a beating heart via right mini-thoracotomy in a patient complicated by a previous laryngectomy, radiation therapy, and a left-sided pulmonary malignancy.
  • [MeSH-major] Cardiac Surgical Procedures. Fibroma / surgery. Heart Neoplasms / surgery. Papillary Muscles / surgery
  • [MeSH-minor] Carotid Stenosis / complications. Heart Atria / surgery. Humans. Laryngectomy / adverse effects. Lung Neoplasms / complications. Male. Middle Aged. Minimally Invasive Surgical Procedures. Radiotherapy / adverse effects. Risk Assessment. Thoracotomy. Tomography, X-Ray Computed. Tracheostomy / adverse effects. Treatment Outcome

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  • (PMID = 17667039.001).
  • [ISSN] 1558-2027
  • [Journal-full-title] Journal of cardiovascular medicine (Hagerstown, Md.)
  • [ISO-abbreviation] J Cardiovasc Med (Hagerstown)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Ramasubbu K, Wheeler TM, Reardon MJ, Dokainish H: Visceral pericardial hemangioma: unusual location for a rare cardiac tumor. J Am Soc Echocardiogr; 2005 Sep;18(9):981
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Visceral pericardial hemangioma: unusual location for a rare cardiac tumor.
  • Coronary angiography revealed no significant coronary disease, but suggested a mass posterior to the heart.
  • Magnetic resonance imaging confirmed the presence of the tumor, without extension into adjacent cardiac chambers or pericardial effusion.
  • At operation, a 4.6- x 3.0-cm tumor attached to the visceral pericardium was excised.
  • Pathologic section resulted in a diagnosis of hemangioma.
  • Hemangiomas account for 2% to 5% of benign cardiac tumors, arising from the cardiac ventricles, atria, valves, and, rarely, the epicardium/pericardium.
  • This case illustrates a very rare location for an unusual benign cardiac tumor.
  • [MeSH-major] Heart Neoplasms / surgery. Heart Neoplasms / ultrasonography. Hemangioma / surgery. Hemangioma / ultrasonography. Pericardium / surgery. Pericardium / ultrasonography

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  • (PMID = 16153530.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Blackmon SH, Patel AR, Bruckner BA, Beyer EA, Rice DC, Vaporciyan AA, Wojciechowski Z, Correa AM, Reardon MJ: Cardiac autotransplantation for malignant or complex primary left-heart tumors. Tex Heart Inst J; 2008;35(3):296-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac autotransplantation for malignant or complex primary left-heart tumors.
  • Malignant or complex benign tumors of the left heart can present a formidable challenge for complete resection, due to anatomic inaccessibility.
  • Cardiac autotransplantation (cardiac explantation, ex-vivo tumor resection, reconstruction, and reimplantation) was introduced for complex benign primary left-heart cardiac tumors by Cooley and for malignant left-heart tumors by Reardon.
  • Herein, we update our previously reported experience.From April 1998 through July 2008, 20 patients underwent 21 cardiac autotransplantations for complex left-sided cardiac tumors that were nonresectable by traditional means.
  • Demographics, tumor histology, operative data, and mortality rates were analyzed.
  • Follow-up was complete in all patients.Of the 20 patients, 17 had malignant lesions, and 3 had benign disease.
  • Fourteen patients had previous resection of their cardiac tumors, and 1 patient had repeat autotransplantation for recurrent disease.
  • There were no operative deaths in patients undergoing autotransplantation alone (0/15), and 3 operative deaths in patients undergoing combined cardiac autotransplantation and pneumonectomy (3/6, 50%).
  • All 3 patients with benign disease survived surgery and are alive without recurrent disease.
  • Local recurrence occurred in 3/18 patients with malignant disease: 1 underwent successful repeat autotransplantation and 2 are receiving chemotherapy.
  • The mean survival for all patients with sarcoma is 22 months.Cardiac autotransplantation enables complete resection and accurate reconstruction in many primary malignant and complex benign left-heart tumors.

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  • (PMID = 18941651.001).
  • [ISSN] 0730-2347
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2565530
  • [Keywords] NOTNLM ; Heart neoplasms/mortality/surgery / heart transplantation/methods / replantation/methods / sarcoma/surgery / transplantation, autologous
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16. McGann C, Tazelaar H, Cho SR, Al-Saghir Y, Shean F, Young W, Schaff H: In vivo detection of encapsulated intracardiac paraganglioma by delayed gadolinium enhancement magnetic resonance imaging. J Cardiovasc Magn Reson; 2005;7(2):371-5
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  • Intracardiac paragangliomas are rare endocrine tumors that are usually benign and can be cured by surgical resection.
  • We present in vivo detection of fibrotic encapsulation in a cardiac paraganglioma using delayed enhancement (DE) cardiac magnetic resonance imaging (CMRI), later confirmed on pathology.
  • This finding improved presurgical risk assessment and helped guide management.
  • Tumor necrosis was also easily identified.
  • DE appears useful in the assessment of intracardiac tumor invasion.
  • [MeSH-major] Contrast Media. Gadolinium DTPA. Heart Neoplasms / diagnosis. Magnetic Resonance Imaging, Cine / methods. Paraganglioma / diagnosis

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  • (PMID = 15881516.001).
  • [ISSN] 1097-6647
  • [Journal-full-title] Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
  • [ISO-abbreviation] J Cardiovasc Magn Reson
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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17. Jacobsen B, Kreutzer M, Meemken D, Baumgärtner W, Herden C: Proposing the term purkinjeoma: protein gene product 9.5 expression in 2 porcine cardiac rhabdomyomas indicates possible purkinje fiber cell origin. Vet Pathol; 2010 Jul;47(4):738-40
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  • [Title] Proposing the term purkinjeoma: protein gene product 9.5 expression in 2 porcine cardiac rhabdomyomas indicates possible purkinje fiber cell origin.
  • Rhabdomyomas, defined as rare benign tumors of striated muscle, predominantly occur in the myocardium.
  • In veterinary medicine, cardiac rhabdomyomas have rarely been reported but most frequently in pigs as an incidental finding.
  • Therefore, the term purkinjeoma or purkinjeomatosis is proposed for cardiac rhabdomyoma in pigs.
  • [MeSH-major] Heart Neoplasms / veterinary. Purkinje Cells / pathology. Rhabdomyoma / veterinary. Swine Diseases / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Immunohistochemistry / veterinary. Swine. Terminology as Topic

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  • (PMID = 20418472.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Hoppe UC: [Cardiac disease in patients with tumors and tumor therapy]. Med Klin (Munich); 2006 Mar 22;101 Suppl 1:31-5
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  • [Title] [Cardiac disease in patients with tumors and tumor therapy].
  • [Transliterated title] Herzerkrankungen bei Tumoren und Tumortherapie.
  • Cardiac disease may occur as direct complications of heart tumors or indirect complications of malignancies related to antineoplastic therapy.
  • While primary cardiac neoplasias are rare, metastases to various cardiac structures are common.
  • Cardiac tumors may cause a wide variety of clinical signs and symptoms.
  • Benign myxomas are the most common primary tumors and often can be cured by total excision.
  • Nearly all primary cardiac malignancies are sarcomas with a poor prognosis.
  • The cardiotoxicity of anticancer agents can lead to significant complications that can affect patients being treated for various noncardiac neoplasias.
  • Cancer treatment, most frequently anthracyclines, but also trastuzumab, cyclophosphamide and others may compromise cardiac function.
  • The severity of such toxicity depends on many factors such as the molecular site of action, the immediate and cumulative dose, the method of administration, the presence of any underlying cardiac condition, and the patient's demographics.
  • Radiation ports that include the heart may produce late coronary artery disease or constrictive pericarditis.
  • Since cardiovascular disease and cancer are both common, precise knowledge of therapeutic interactions and complications is warranted.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Cardiomyopathies / chemically induced. Heart / radiation effects. Heart Neoplasms / secondary. Myxoma / diagnosis. Neoplasms / diagnosis. Radiation Injuries / diagnosis

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  • (PMID = 16802515.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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19. Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA: Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. Circ Res; 2009 Jul 31;105(3):304-11
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  • [Title] Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction.
  • RATIONALE: Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with a broad array of clinical manifestations, including benign and malignant tumors, and characteristic cutaneous findings.
  • The disease gene, NF1, encodes neurofibromin, a ubiquitously expressed protein that acts, in part, as a Ras-GAP (GTP-ase activating protein), downregulating the activity of activated Ras protooncogenes.
  • In animal models, endothelial and smooth muscle expression of the disease gene is critical for normal heart development and the prevention of vascular disease, respectively.
  • OBJECTIVE: To determine the role of NF1 in the postnatal and adult heart.
  • Nf1mKO mice have normal embryonic cardiovascular development but have marked cardiac hypertrophy, progressive cardiomyopathy, and fibrosis in the adult.
  • Hyperactivation of Ras and downstream pathways are seen in the heart with the loss of Nf1, along with activation of a fetal gene program.
  • CONCLUSIONS: This report describes a critical role of Nf1 in the regulation of cardiac growth and function.
  • Activation of pathways known to be involved in cardiac hypertrophy and dysfunction are seen with the loss of myocardial neurofibromin.

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  • (PMID = 19574548.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL062974-10; United States / NHLBI NIH HHS / HL / K08 HL075179; United States / NHLBI NIH HHS / HL / R01 HL062974-10; United States / NHLBI NIH HHS / HL / R01 HL062974; United States / NHLBI NIH HHS / HL / R01 HL62974
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GTPase-Activating Proteins; 0 / Neurofibromin 1; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ NIHMS131413; NLM/ PMC2747036
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20. Palecek T, Lindner J, Vitkova I, Linhart A: Papillary fibroelastoma arising from the left ventricular apex associated with nonspecific systemic symptoms. Echocardiography; 2008 May;25(5):526-8
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  • Primary cardiac tumors are very rare findings.
  • Papillary fibroelastomas are benign tumors comprising less than 10% of all primary cardiac neoplasms.
  • [MeSH-major] Fibroma / ultrasonography. Heart Neoplasms / ultrasonography
  • [MeSH-minor] Echocardiography. Female. Heart Ventricles / pathology. Heart Ventricles / surgery. Heart Ventricles / ultrasonography. Humans. Middle Aged

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  • (PMID = 18177380.001).
  • [ISSN] 0742-2822
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Kutay V, Yakut C, Ekim H: Mitral annular tumors: report of two cases in childhood. J Card Surg; 2006 Mar-Apr;21(2):191-4
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  • [Title] Mitral annular tumors: report of two cases in childhood.
  • Primary tumors of the mitral valve are extremely rare especially in the pediatric age group; only a few cases have been reported previously.
  • The clinical appearance of the tumor may mimic other pathological findings of heart structures or remain asymptomatic.
  • We describe two different benign primary cardiac tumors, which were hemangioma and myxoma originating from the anterior annulus of the mitral valve and presenting with an unusual clinical course in two children.
  • Both tumors were resected successfully with mitral valve conservation and there was no recurrence at 6-month and 1-year follow-ups.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangioma / diagnosis. Myxoma / diagnosis
  • [MeSH-minor] Cardiac Surgical Procedures / methods. Child. Diagnosis, Differential. Echocardiography, Transesophageal. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Mitral Valve

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  • (PMID = 16492286.001).
  • [ISSN] 0886-0440
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Thomas-de-Montpréville V, Nottin R, Dulmet E, Serraf A: Heart tumors in children and adults: clinicopathological study of 59 patients from a surgical center. Cardiovasc Pathol; 2007 Jan-Feb;16(1):22-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heart tumors in children and adults: clinicopathological study of 59 patients from a surgical center.
  • BACKGROUND: Heart tumors are rare lesions with variegated histological types.
  • RESULTS: Congenital tumors (n = 17; 29%), including rhabdomyomas (n = 9), ventricular fibromas (n = 6), and hemangiomas (n = 1), required surgery mainly because of mass effect.
  • Acquired benign tumors (n = 28; 47%) included myxomas (n = 21), fibroelastomas (n = 3), myofibroblastic inflammatory tumors (n = 2), and lipomas (n = 2).
  • These benign noncongenital tumors were all treated by complete resection, except for an incompletely resected lipoma of the mitral valve.
  • Primary sarcomas (n = 8; 14%) were mostly vascular tumors (five of eight), and patients with high-grade tumors had a mean survival of 15 months (n = 5).
  • Cardiac metastases (n = 6; 10%) were from carcinomas (n = 3) or sarcomas (n = 3); apart from a necrotic metastasis, all patients died (mean survival of 6 months).
  • CONCLUSIONS: This study shows that, regardless of patients' age, heart tumors can be classified as: (a) congenital lesions, which are spontaneously nonprogressive or regressive lesions possibly requiring surgery mainly because of mass effect;.
  • (b) acquired benign tumors, which are lesions requiring surgery often because of embolization risk; and (c) primary and secondary malignant tumors, which are lesions with globally poor prognosis but with some indications for resection.
  • [MeSH-major] Fibroma / pathology. Heart Neoplasms / pathology. Myxoma / pathology. Rhabdomyoma / pathology. Rhabdomyosarcoma / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Echocardiography. Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Regression, Spontaneous. Retrospective Studies

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  • (PMID = 17218211.001).
  • [ISSN] 1054-8807
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Daccarett M, Burke P, Saba S: Incidental finding of a large pulmonary valve fibroelastoma: a case report. Eur J Echocardiogr; 2006 Jun;7(3):253-6
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  • [Title] Incidental finding of a large pulmonary valve fibroelastoma: a case report.
  • Papillary fibroelastoma (PFE) is an uncommon primary neoplasm of cardiac origin.
  • They are solitary neoplasms that historically were an incidental finding at the time of autopsy.
  • With the advent of two-dimensional echocardiography, symptomatic cases have been reported in current literature, thus causing a paradigm shift in the management of these tumors.
  • Although the majority of PFE are benign, because of their potential risk for complication related to embolic and obstructive phenomena, they are now considered hazardous and require tumor excision even in asymptomatic patients.
  • [MeSH-major] Echocardiography. Fibroma / ultrasonography. Heart Neoplasms / ultrasonography. Pulmonary Valve

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  • (PMID = 15927535.001).
  • [ISSN] 1525-2167
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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24. Strzelecki M, Materka A, Drozdz J, Krzeminska-Pakula M, Kasprzak JD: Classification and segmentation of intracardiac masses in cardiac tumor echocardiograms. Comput Med Imaging Graph; 2006 Mar;30(2):95-107
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Classification and segmentation of intracardiac masses in cardiac tumor echocardiograms.
  • This paper describes an automatic method for classification and segmentation of different intracardiac masses in tumor echocardiograms.
  • Identification of mass type is highly desirable, since to different treatment options for cardiac tumors (surgical resection) and thrombi (effective anticoagulant treatment) are possible.
  • Correct diagnosis of the character of intracardiac mass in a living patient is a true challenge for a cardiologist; therefore, an objective image analysis method may be useful in heart diseases diagnosis.
  • In addition, classification and segmentation of selected benign tumor echocardiograms were performed.
  • Oscillator network was used with network weights defined for both whole texture region and texture boundary detection for the tumor segmentation.
  • [MeSH-major] Echocardiography. Heart Neoplasms / classification. Heart Neoplasms / ultrasonography. Image Interpretation, Computer-Assisted / methods

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  • (PMID = 16476535.001).
  • [ISSN] 0895-6111
  • [Journal-full-title] Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
  • [ISO-abbreviation] Comput Med Imaging Graph
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Hu SS, Wang XQ, Xu JP, Sun LZ, Liu YL: [Experiences in surgical treatment of cardiac tumors]. Zhonghua Yi Xue Za Zhi; 2006 Mar 21;86(11):766-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experiences in surgical treatment of cardiac tumors].
  • OBJECTIVE: To summarize the experiences in surgical treatment of cardiac tumors.
  • METHODS: The results of surgical treatment of 494 patients with cardiac tumors hospitalized from 1975 to 2004, aged 43 +/- 16 (4 months to 78 years), 432 with myxoma, 27 with benign nonmyxoma, and 35 with malignant tumors, were analyzed.
  • RESULTS: Complete resection of malignant tumor was achieved in 10 cases (28.6%), and subtotal resection was achieved in 15 cases (42.9%).
  • Only biopsy was performed in 10 patients (28.6%) because of extensive metastasis of tumor.
  • Hospital death occurred in 11 myxoma patients (2.5%), and 3 malignant tumor patients (8.6%), and none of the benign non-myxoma tumor patients.
  • Follow-up for malignant tumors showed 18 (51.4%) late deaths because of recurrence or metastasis, occurring 2 months to 2 years after operation.
  • CONCLUSION: Excellent immediate and long-term operative results can be obtained for benign cardiac tumors.
  • However, for the patients with malignant tumors the survival chances are dismal.
  • [MeSH-major] Heart Neoplasms / surgery. Myxoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cardiac Surgical Procedures. Child. Child, Preschool. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16681953.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Haverkamp MC, Scholte AJ, Holman ER, Jongbloed MR, Schippers EF, de Roos A, van der Wall EE, Poldermans D, Bax JJ, Schalij MJ: Contrast echocardiography as a useful additional diagnostic tool in evaluating a primary cardiac tumor. Eur J Echocardiogr; 2005 Oct;6(5):388-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast echocardiography as a useful additional diagnostic tool in evaluating a primary cardiac tumor.
  • The current report describes a case of a primary cardiac lymphoma.
  • For early and appropriate treatment of a cardiac mass it is not only important to determine its localization and extension but also to differentiate between malignant and benign lesions.
  • This report demonstrates that not only transthoracic echocardiography but also the other different forms of echocardiography such as transesophageal echocardiography, as well as contrast and intracardiac echocardiography, are useful tools in the diagnostic workup of cardiac masses.
  • [MeSH-major] Echocardiography. Echocardiography, Transesophageal. Heart Neoplasms / ultrasonography. Lymphoma, Large B-Cell, Diffuse / ultrasonography
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Heart Atria / ultrasonography. Heart Ventricles / ultrasonography. Humans. Male. Middle Aged

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  • (PMID = 16153561.001).
  • [ISSN] 1525-2167
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Martínez Quesada M, Trujillo Berraquero F, Almendro Delia M, Hidalgo Urbano R, Cruz Fernández JM: [Cardiac hamartoma. Case report and literature review]. Rev Esp Cardiol; 2005 Apr;58(4):450-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac hamartoma. Case report and literature review].
  • Primary cardiac tumors are infrequent and usually benign.
  • They are sometimes an incidental finding in an asymptomatic patient.
  • The pathologic diagnosis was hamartoma of mature cardiac myocytes.
  • We discuss the usefulness of imaging techniques for identifying cardiac masses.
  • [MeSH-major] Hamartoma / diagnosis. Heart Diseases / diagnosis

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  • (PMID = 15847741.001).
  • [ISSN] 0300-8932
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 13
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28. Smith MA: Multiple synchronous atrial lipomas. Cardiovasc Pathol; 2007 May-Jun;16(3):187-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The incidence of primary tumors of the heart is low.
  • Three quarters of cardiac neoplasms are benign.
  • Cardiac lipomas are a mostly asymptomatic benign tumor that makes up less than 10% of primary heart tumors.
  • [MeSH-major] Heart Neoplasms / pathology. Lipoma / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Coronary Stenosis / etiology. Coronary Stenosis / pathology. Female. Heart Atria / pathology. Heart Atria / surgery. Humans. Middle Aged. Treatment Outcome. Tricuspid Valve / pathology

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  • (PMID = 17502250.001).
  • [ISSN] 1054-8807
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Kuroczyński W, Peivandi AA, Ewald P, Pruefer D, Heinemann M, Vahl CF: Cardiac myxomas: short- and long-term follow-up. Cardiol J; 2009;16(5):447-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac myxomas: short- and long-term follow-up.
  • BACKGROUND: Cardiac myxomas are the most frequently encountered benign intracardiac tumors, that, if left untreated, are inexorably progressive and potentially fatal.
  • Patients with cardiac myxoma can be treated only by surgical removal.
  • This study summarizes our experience over 22 years with these tumors.
  • METHODS: Fifty seven patients (M/F: 14/43, age: 57.9 +/- 14.6 years) with cardiac myxomas underwent surgical resection at our institution.
  • Cause of death was cardiac in 40% of the patients (n = 2) and non-cardiac in the other 60% (n = 3).
  • CONCLUSIONS: Surgical excision of cardiac myxoma carries a low operative risk and gives excellent short-term and long-term results.
  • Surgical excision of the tumor appears to be curative, with few recurrences at long-term follow-up.
  • After diagnosis, surgery should be performed urgently, in order to prevent complications such as embolic events or obstruction of the mitral orifice.
  • [MeSH-major] Cardiac Surgical Procedures. Heart Neoplasms / surgery. Myxoma / surgery
  • [MeSH-minor] Adult. Aged. Cardiovascular Diseases / etiology. Cardiovascular Diseases / mortality. Cause of Death. Female. Humans. Kaplan-Meier Estimate. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Retrospective Studies. Therapeutics. Time Factors

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  • (PMID = 19753524.001).
  • [ISSN] 1897-5593
  • [Journal-full-title] Cardiology journal
  • [ISO-abbreviation] Cardiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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30. Smith LP, Podraza J, Proud VK: Polyhydramnios, fetal overgrowth, and macrocephaly: prenatal ultrasound findings of Costello syndrome. Am J Med Genet A; 2009 Feb 15;149A(4):779-84
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  • Complications include failure to thrive, hypertrophic cardiomyopathy with arrhythmias, and benign and malignant tumors.
  • This report describes a new case of Costello syndrome in a preterm infant born at 27 weeks gestation and diagnosed with Costello syndrome at 7 weeks of life who died at 6 months of age due to cardiac and pulmonary complications.
  • Based on this study, ultrasound identification of polyhydramnios in the context of prenatal overgrowth, especially with relative macrocephaly, needs to raise the possibility of a diagnosis of Costello syndrome in the fetus because of the life-threatening cardiac complications that may occur early in the newborn period.
  • [MeSH-minor] Arrhythmias, Cardiac / genetics. Birth Weight / genetics. Female. Genes, ras. Humans. Infant. Infant, Newborn. Mutation, Missense. Phenotype. Pregnancy. Syndrome. Ultrasonography, Prenatal


31. Hayashi H, Hidaka F, Kiriyama T, Sato H, Takagi R, Kumita S: A left ventricular lipoma diagnosed on three-dimensional electrocardiogram-gated cardiac computed tomography. Heart Vessels; 2008 Sep;23(5):366-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A left ventricular lipoma diagnosed on three-dimensional electrocardiogram-gated cardiac computed tomography.
  • Cardiac lipomas are extremely rare primary benign cardiac tumors.
  • The cardiac lipoma was qualitatively evaluated and its location was accurately determined noninvasively with the use of three-dimensional images reconstructed from data acquired by electrocardiogram-gated cardiac computed tomography (CT).
  • [MeSH-major] Electrocardiography / methods. Heart Neoplasms / diagnostic imaging. Imaging, Three-Dimensional. Lipoma / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Heart Ventricles. Humans. Male. Middle Aged

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  • (PMID = 18810588.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Berne JP, Bouchot O, Jazayeri S, Tatou E, Gomez-Bielfeld MC, Martin L, Brenot R, David M: [Cardiac papillary fibroelastoma, a rare valvular source of cerebral embolism: report of two cases]. Ann Cardiol Angeiol (Paris); 2009 Feb;58(1):61-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac papillary fibroelastoma, a rare valvular source of cerebral embolism: report of two cases].
  • Cardiac papillary fibroelastomas are very rare and benign tumors, usually involving heart valves.
  • Diagnosis is evoked by echocardiography and confirmed by histopathological examination.
  • The only curative treatment consists of the excision of the tumor under cardiopulmonary bypass.
  • Transthoracic and transoesophageal echocardiography detected tumors of the mitral and aortic valve in the first and second patients, respectively.
  • Preserving the valve integrity, both masses were surgically excised and pathological findings confirmed the diagnosis.
  • [MeSH-major] Aortic Valve. Endocardial Fibroelastosis / complications. Heart Neoplasms / complications. Intracranial Embolism / etiology. Mitral Valve. Papillary Muscles
  • [MeSH-minor] Adult. Cardiac Surgical Procedures / methods. Echocardiography, Transesophageal. Fibroma. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18980749.001).
  • [ISSN] 1768-3181
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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33. Vizzardi E, D'Aloia A, Chiari E, Nardi M, Zanini G, Cabras R, Faden G, Maiandi C, Cas LD: Tricuspid valve myxoma in a patient with congestive heart failure. Cases J; 2010;3:21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tricuspid valve myxoma in a patient with congestive heart failure.
  • Myxomas are the most frequent benign primary cardiac tumours (50% of benign heart tumours).
  • This kind of tumour is most likely to be localized in the left atrium, followed by the right atrium, right ventricle and left ventricle.

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  • (PMID = 20205805.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2823714
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34. Reardon MJ, Walkes JC, Benjamin R: Therapy insight: malignant primary cardiac tumors. Nat Clin Pract Cardiovasc Med; 2006 Oct;3(10):548-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapy insight: malignant primary cardiac tumors.
  • Benign cardiac tumors are resected with a high degree of success with modern cardiac surgical techniques.
  • Malignant cardiac tumors, however, continue to pose a therapeutic challenge to cardiac surgeons and oncologists because of the technical difficulty involved in extensive cardiac resections and the aggressive biological nature of the tumors.
  • The majority of malignant cardiac tumors are sarcomas and can be categorized as right heart sarcoma, left heart sarcoma or pulmonary artery sarcoma.
  • Right heart sarcomas are generally angiosarcomas, which infiltrate widely and metastasize early.
  • Left heart sarcomas, although large, are often less infiltrative and metastasize later than right heart sarcomas, but a similar approach to treatment is usually employed.
  • Surgical resection is more-frequently necessary for left heart sarcomas because of intracardiac blood flow obstruction and congestive heart failure, although the anatomic position and relation of these tumors to cardiac structures can complicate surgery.
  • We have developed and employed the technique of cardiac autotransplantation, which involves cardiac excision, ex vivo tumor resection with cardiac reconstruction, and cardiac reimplantation, to lessen these technical difficulties.
  • [MeSH-major] Heart Neoplasms / surgery. Hemangiosarcoma / surgery. Histiocytoma, Malignant Fibrous / surgery. Pulmonary Artery / surgery. Vascular Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cardiac Surgical Procedures. Chemotherapy, Adjuvant. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Prognosis

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  • (PMID = 16990840.001).
  • [ISSN] 1743-4297
  • [Journal-full-title] Nature clinical practice. Cardiovascular medicine
  • [ISO-abbreviation] Nat Clin Pract Cardiovasc Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 23
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35. Bossert T, Gummert JF, Battellini R, Richter M, Barten M, Walther T, Falk V, Mohr FW: Surgical experience with 77 primary cardiac tumors. Interact Cardiovasc Thorac Surg; 2005 Aug;4(4):311-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical experience with 77 primary cardiac tumors.
  • BACKGROUND: To assess the prognosis and to develop management strategies for primary cardiac tumors all patients were included in an ongoing study.
  • 1994 until December 2003 we prospectively evaluated all patients with cardiac tumors.
  • RESULTS: There were a total of 77 primary cardiac tumors.
  • Seventy-three were benign: myxoma (n=59), papillary fibroelastoma (n=11), lipoma (n=2), fibroma (n=1) and four malignant sarcoma (n=4).
  • There were 4 primary cardiac sarcomas, located in the right ventricle (n=2), the pulmonary valve (n=1) and left atrium (n=1).
  • Minimal invasive right thoracotomy was utilized in 19 of 73 patients all with benign tumor.
  • There were two early deaths (3%): a myxoma patient with triple vessel disease and a LVEF less than 30% and one sarcoma patient.
  • No recurrence or late death was observed in the group of benign tumors.
  • However, two remaining patients with sarcoma had recurrent disease 10 and 15 month later, respectively.
  • CONCLUSION: Surgical excision of benign cardiac tumors is a safe and curative treatment, which is feasible using minimally invasive right thoracotomy approach and provides excellent results.
  • However, therapy of malignant cardiac tumors continues to have a poor prognosis despite individualization of approach.

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  • (PMID = 17670419.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Catalfamo L, Lombardo G, Siniscalchi EN, Nava C, Familiari E, Francesco Sde P: Rhabdomyomas of the submandibular and sublingual glands. J Craniofac Surg; 2010 May;21(3):927-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rhabdomyomas are rare benign mesenchymal tumors distinguished in cardiac and extracardiac forms.
  • [MeSH-major] Rhabdomyoma / radiography. Sublingual Gland Neoplasms / radiography. Submandibular Gland Neoplasms / radiography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20485085.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Goldberg SP, Knott-Craig CJ, Boston US, Mari GC, Colvin EV, Chin TK: Surgical management of unusual cardiac tumors in infants and children. World J Pediatr Congenit Heart Surg; 2010 Jul;1(2):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of unusual cardiac tumors in infants and children.
  • While most primary tumors of the heart are histologically benign, they are significant space-occupying lesions with serious functional implications for the heart and lungs.
  • Herein, we highlight our experience with the surgical management of selected cardiac tumors in the pediatric population between 2008 and 2010. (1) Intrapericardial teratomas in the fetus can produce fatal tamponade from compression by the attendant pericardial effusion, and a critical life-saving maneuver preoperatively is to drain the effusion prenatally, followed by an expeditious resection after birth. (2) Rhabdomyomas, the most common of the pediatric cardiac tumors, can be intracavitary, large, and associated with the mitral subvalvular apparatus. (3) Cardiac fibromas should be aggressively resected or at least debulked, especially given their propensity for dysrrhythmias.

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  • (PMID = 23804823.001).
  • [ISSN] 2150-1351
  • [Journal-full-title] World journal for pediatric & congenital heart surgery
  • [ISO-abbreviation] World J Pediatr Congenit Heart Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; cardiac tumor / child / infant
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38. Koçak H, Ozyazicioğlu A, Gündoğdu C, Sevimli S: Cardiac hemangioma complicated with cerebral and coronary embolization. Heart Vessels; 2005 Nov;20(6):296-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac hemangioma complicated with cerebral and coronary embolization.
  • Cardiac hemangiomas are rare, benign vascular tumors of the heart.
  • Because of their clinical manifestations, diagnosis is difficult and few surgeons can draw from extensive experience.
  • The purpose of this study was to report an additional case of cardiac hemangioma and to analyze the unexpected aspect of this disease.
  • Histopathological examination revealed that the tumor was a hemangioma.
  • [MeSH-major] Heart Neoplasms / complications. Heart Ventricles / surgery. Hemangioma / complications. Intracranial Embolism / etiology. Myocardial Infarction / etiology. Thrombosis / etiology
  • [MeSH-minor] Adult. Capillaries / pathology. Cardiopulmonary Bypass. Diagnosis, Differential. Echocardiography. Follow-Up Studies. Humans. Male. Postoperative Complications / diagnostic imaging


39. Costa MJ, Makaryus AN, Rosman DR: A rare case of a cardiac papillary fibroelastoma of the pulmonary valve diagnosed by echocardiography. Int J Cardiovasc Imaging; 2006 Apr;22(2):199-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of a cardiac papillary fibroelastoma of the pulmonary valve diagnosed by echocardiography.
  • Primary cardiac tumors are rare.
  • The majority of primary tumors of the heart are benign with papillary fibroelastomas being the third most common after myxomas and lipomas respectively.
  • Papillary fibroelastomas represent the most common valvular tumor of the heart.
  • Although benign, papillary fibroelastomas have the potential to cause turbulent flow, thrombus formation, and severe cerebral or coronary embolic disease.
  • The majority of fibroelastomas have been described on the left side of the heart involving the aortic and mitral valves.
  • [MeSH-major] Fibroma / diagnostic imaging. Heart Neoplasms / diagnostic imaging. Heart Valve Diseases / diagnostic imaging. Pulmonary Valve / diagnostic imaging
  • [MeSH-minor] Aged. Diagnosis, Differential. Echocardiography, Transesophageal. Endocardial Fibroelastosis / diagnostic imaging. Endocardial Fibroelastosis / surgery. Humans. Male

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  • (PMID = 16077998.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Braun S, Schrötter H, Reynen K, Schwencke C, Strasser RH: Myocardial infarction as complication of left atrial myxoma. Int J Cardiol; 2005 May 11;101(1):115-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although cardiac myxomas are histologically benign, they tend to form emboli and cause intracardiac obstruction, so that they must be classified as potentially fatal tumors of the heart.
  • The probability of arterial embolism is closely correlated with the morphology of the tumor.
  • These may present as acute myocardial ischemia with the typical clinical symptoms of acute myocardial infarction, as a silent infarct, shock, syncope or as sudden cardiac death.
  • Interestingly there is a tendency for spontaneous recanalization of the obstructed coronary vessels, perhaps because of the tumors' tissue composition.
  • [MeSH-major] Heart Atria / physiopathology. Heart Neoplasms / complications. Myocardial Infarction / etiology. Myxoma / complications
  • [MeSH-minor] Acute Disease. Female. Humans. Middle Aged. Risk Factors. Thromboembolism / physiopathology

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  • (PMID = 15860393.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 71
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41. Kim EY, Choe YH, Sung K, Park SW, Kim JH, Ko YH: Multidetector CT and MR imaging of cardiac tumors. Korean J Radiol; 2009 Mar-Apr;10(2):164-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multidetector CT and MR imaging of cardiac tumors.
  • The purpose of this article is to provide a current review of the spectrum of multidetector CT (MDCT) and MRI findings for a variety of cardiac neoplasms.
  • In the diagnosis of cardiac tumors, the use of MDCT and MRI can help differentiate benign from malignant masses.
  • Especially, the use of MDCT is advantageous in providing anatomical information and MRI is useful for tissue characterization of cardiac masses.
  • Knowledge of the characteristic MRI findings of benign cardiac tumors or thrombi can be helpful to avoid unnecessary surgical procedures.
  • Presurgical assessment of malignant cardiac tumors with the use of MDCT and MRI may allow determination of the resectability of tumors and planning for the reconstruction of cardiac chambers.
  • [MeSH-major] Heart Neoplasms / pathology. Magnetic Resonance Imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Contrast Media / administration & dosage. Electrocardiography. Hemangioma / pathology. Humans. Lymphoma / pathology. Neoplasms, Connective and Soft Tissue / pathology. Papilloma / pathology

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  • (PMID = 19270863.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 26
  • [Other-IDs] NLM/ PMC2651440
  • [Keywords] NOTNLM ; Cardiac tumor / Magnetic resonance (MR) / Multidetector CT
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42. Yamaguchi M, Yagi K, Ikeya E, Fujimura T, Taguchi J, Shibuya M, Inamura S, Kanabuchi K: A case report of papillary fibroelastoma attached to chorda tendineae of mitral valve. Tokai J Exp Clin Med; 2006 Jul;31(2):56-9
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  • A bulbar mass attached to mitral valve anterior leaflet was discovered in an echocardiography within detailed examination of ischemic heart disease accidentally.
  • We diagnosed him as ischemic heart disease and doubt of heart tumor.
  • We dissected the tumor together with one chorda tendineae of mitral valve, and a performed aorta - coronary bypass surgery.
  • We diagnosed the tumor as papillary fibroelastoma by pathological diagnosis.
  • Papillary fibroelastoma is extremely rare with 7-9% of benign tumor of heart primary.
  • The tumor is benign, but there is a problem to cause embolism.
  • Therefore, when we discovered papillary fibroelastoma, surgical resection of the tumor is the first-line therapy.
  • Papillary fibroelastoma is benign tumor, but the pathological characteristic is still unidentified.
  • [MeSH-major] Chordae Tendineae / pathology. Fibroma / pathology. Heart Neoplasms / pathology. Mitral Valve / pathology

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  • (PMID = 21302223.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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43. Gopaldas RR, Atluri PV, Blaustein AS, Bakaeen FG, Huh J, Chu D: Papillary fibroelastoma of the aortic valve: operative approaches upon incidental discovery. Tex Heart Inst J; 2009;36(2):160-3
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  • Papillary fibroelastomas are the most common benign neoplasms of the cardiac valvular structures, and they are being recognized more frequently because of higher-resolution imaging technology.
  • Surgical resection should be offered to all patients who have symptoms and to asymptomatic patients who have pedunculated lesions or tumors larger than 1 cm in diameter.
  • The timely recognition of this asymptomatic tumor enabled a modified operative approach: the patient underwent myocardial revascularization with concomitant valve-sparing resection of the tumor.
  • We discuss the pathophysiology of fibroelastomas of the aortic valve and operative approaches to the management of these tumors when they are discovered incidentally.

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  • (PMID = 19436815.001).
  • [ISSN] 1526-6702
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2676606
  • [Keywords] NOTNLM ; Aortic valve/pathology/surgery/ultrasonography / cardiac surgical procedures/methods / echocardiography, transesophageal / fibroma/complications/pathology/surgery/ultrasonography / heart neoplasms/diagnosis/pathology/surgery/therapy/ultrasonography
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44. Alghamdi AA, Sheth T, Manowski Z, Djoleto OF, Bhatnagar G: Utility of cardiac CT and MRI for the diagnosis and preoperative assessment of cardiac paraganglioma. J Card Surg; 2009 Nov-Dec;24(6):700-1
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  • [Title] Utility of cardiac CT and MRI for the diagnosis and preoperative assessment of cardiac paraganglioma.
  • BACKGROUND: Cardiac paragangliomas are rare cardiac tumors that are usually benign.
  • METHODS: We report a case of 39-year-old male who, during the work up of acute coronary syndrome with coronary angiography, cardiac computed tomography (CT) and magnetic resonance imaging (MRI), was found to have cardiac paraganglioma.
  • RESULTS: The tumor was intrapericardial, arising at the level of proximal left anterior descending artery.
  • The tumor was completely resected and the postoperative course was uneventful.
  • CONCLUSION: Cardiac CT and MRI are valuable in characterizing and preoperative planning of primary cardiac paragangliomas.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / surgery. Magnetic Resonance Imaging. Paraganglioma / diagnosis. Paraganglioma / surgery. Tomography, X-Ray Computed
  • [MeSH-minor] Acute Coronary Syndrome / diagnosis. Adult. Atrial Appendage / pathology. Atrial Appendage / surgery. Coronary Angiography. Diagnosis, Differential. Heart Ventricles / pathology. Heart Ventricles / surgery. Humans. Male. Postoperative Complications / diagnosis

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  • (PMID = 19682163.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Fresneau B, Oberlin O, Brugières L, Valteau-Couanet D, Patte C: [Malignant primary cardiac tumors in childhood and adolescence]. Arch Pediatr; 2010 May;17(5):495-501
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  • [Title] [Malignant primary cardiac tumors in childhood and adolescence].
  • [Transliterated title] Les tumeurs cardiaques primitives malignes de l'enfant et de l'adolescent.
  • Primary heart tumors are uncommon in children.
  • The majority of them are benign, with only 10% malignant.
  • Among malignant cardiac tumors, sarcoma (rhabdomyosarcoma, angiosarcoma, synovial sarcoma) and lymphoma (Burkitt's lymphoma, large B-cell lymphoma, lymphoblastic lymphoma) predominate.
  • There are few published pediatric series on malignant primary cardiac tumors.
  • We report here 3 observations of primary malignant cardiac tumors, 2 cases of sarcoma (angiosarcoma and synovial sarcoma) and 1 case of Burkitt's lymphoma.
  • A precise pathological diagnosis is necessary for the proper management of these patients.
  • Therefore, the prognosis of cardiac sarcoma remains poor.
  • For primary cardiac lymphoma, management should not be different from lymphoma in other locations.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Heart Neoplasms / diagnosis. Hemangiosarcoma / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Cough / etiology. Diagnosis, Differential. Dyspnea / etiology. Echocardiography. Fatal Outcome. Female. Heart Atria / pathology. Heart Atria / surgery. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Pulmonary Heart Disease / diagnosis. Pulmonary Heart Disease / etiology. Superior Vena Cava Syndrome / diagnosis. Superior Vena Cava Syndrome / etiology. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20338733.001).
  • [ISSN] 1769-664X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Imai Y, Taketani T, Maemura K, Takeda N, Harada T, Nojiri T, Kawanami D, Monzen K, Hayashi D, Murakawa Y, Ohno M, Hirata Y, Yamazaki T, Takamoto S, Nagai R: Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy. Circ J; 2005 Aug;69(8):994-5
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  • [Title] Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy.
  • A 60 year-old male was referred for treatment of a cardiac myxoma in the right atrium.
  • He had a past history of left atrial cardiac myxoma at age 49 and pituitary microadenoma related to acromegaly at age 55.
  • He did not have a family history of cardiac neoplasm or endocrinopathy.
  • The intracardiac tumor was resected and its pathology was compatible with myxoma.
  • A diagnosis of Carney complex (CNC) was made because the diagnostic criteria of this neoplastic syndrome were satisfied by the presence of recurrent cardiac myxoma, endocrine tumor and spotty skin pigmentation.
  • Although it is the most common, usually benign, cardiac tumor, myxoma can cause a critical clinical situation and thus detecting the PRKAR1A mutation can assist with prognosis.
  • [MeSH-major] Endocrine Gland Neoplasms / genetics. Heart Neoplasms / genetics. Mutation. Myxoma / genetics. Proteins / genetics
  • [MeSH-minor] Acromegaly / complications. Acromegaly / diagnosis. Acromegaly / genetics. Cyclic AMP-Dependent Protein Kinase RIalpha Subunit. Cyclic AMP-Dependent Protein Kinases. Humans. Male. Middle Aged

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  • (PMID = 16041174.001).
  • [ISSN] 1346-9843
  • [Journal-full-title] Circulation journal : official journal of the Japanese Circulation Society
  • [ISO-abbreviation] Circ. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / PRKAR1A protein, human; 0 / Proteins; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases
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47. Lather N, Islam M, Fergus IV: Symptomatic metastatic right atrial lymphoma in a patient with AIDS presenting with pulmonary embolization. Rev Cardiovasc Med; 2008;9(4):275-9
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  • Tumors involving the heart are rare, and the majority of them are benign.
  • Secondary lymphoma with localization to the heart is the third most common malignant heart tumor and is more common, by far, than primary cardiac lymphomas.
  • Patients can also present with obstructive symptoms, based on the location and size of the tumor, and signs such as elevated jugular venous pressure, peripheral edema, ascites, and hepatomegaly.
  • Transthoracic echocardiography is the initial modality of choice for diagnosis of cardiac lymphomas because it is readily available and helps localize the tumor, but transesophageal echocardiography and magnetic resonance imaging remain the best tests for evaluation.
  • Treatment consists primarily of chemotherapy, and anticoagulation can be used in certain cases where embolization of the tumor is likely.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Heart Atria / pathology. Heart Neoplasms / diagnosis. Lymphoma, AIDS-Related / diagnosis. Pulmonary Embolism / virology


48. Qaddoumi I, Ellison DW, Morris EB, Broniscer A, Boop F, Merchant T, Palmer SL, Gajjar A: Dysembryoplastic neuroepithelial tumors and cognitive outcome: cure at a price? Cancer; 2010 Dec 1;116(23):5461-9
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  • [Title] Dysembryoplastic neuroepithelial tumors and cognitive outcome: cure at a price?
  • BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children.
  • These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection.
  • RESULTS: The patient cohort included 8 boys and 3 girls (median age at diagnosis, 10 years); all patients presented with seizures: 4 complex partial, 3 generalized tonic-clonic, 2 absence, 1 partial simple, and 1 not classified.
  • Of the 11 patients, 1 died of cardiac fibrosis, and tumors recurred or progressed in 4 (36%) patients.
  • CONCLUSIONS: The high recurrence and progression rates of DNETs and the high rate of abnormal neurocognitive test results noted in the current study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Cognition Disorders / etiology. Neoplasms, Neuroepithelial / diagnosis. Neoplasms, Neuroepithelial / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Craniotomy / adverse effects. Educational Status. Female. Humans. Intelligence Tests. Male. Neoplasm Recurrence, Local. Seizures / diagnosis. Treatment Outcome

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  • [Copyright] Copyright © 2010 American Cancer Society.
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  • (PMID = 20672357.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS218175; NLM/ PMC3556450
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49. Blackmon SH, Kassis ES, Ge Y, Goldfarb R, Reardon M: Left atrial myxoma embolus to the renal artery: should a nephrectomy be advised? Ann Thorac Surg; 2010 Jul;90(1):289-92
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  • Cardiac myxoma represents the most common primary cardiac tumor, which accounts for 75% of all benign cardiac tumors.
  • Resection is generally recommended for cardiac myxomata; once identified but less understood is what to do with systemic emboli.
  • Excision of the tumor required cardiac autotransplantation and mitral valve replacement.
  • [MeSH-major] Heart Neoplasms / surgery. Myxoma / surgery. Neoplastic Cells, Circulating / pathology. Nephrectomy. Renal Artery Obstruction / surgery. Vascular Neoplasms / surgery
  • [MeSH-minor] Cardiac Surgical Procedures. Humans. Male. Renal Artery / pathology. Renal Artery / surgery. Replantation. Young Adult

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20609801.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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50. Panagiotou M, Panagopoulos ND, Ravazoula P, Kaklamanis L, Koletsis EN: Large asymptomatic left atrial myxoma with ossification: case report. J Cardiothorac Surg; 2008;3:19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Atrial myxomas are the most common primary cardiac tumors.
  • They are usually small or moderate in size by the time of the diagnosis, exhibiting non specific cardiac or systemic symptoms, and are most frequently soft and friable without microscopic signs of ossification.
  • CASE PRESENTATION: An asymptomatic 58-year-old male with a giant left atrial tumor, was transferred to our Unit for surgical treatment.
  • The tumor was an incidental finding during a work-up for hemoptysis due to bronchectasis.
  • The coronary angiogram showed tumor vessels originating from the RCA.
  • The tumor macroscopically did not resemble a myxoma, considering its dimensions (12 x 10 cm) and its solid substance.
  • The pathology study revealed a benign myxoma with excessive osteoid (mature bone) content.
  • CONCLUSION: We consider our case as extremely rare because of the asymptomatic course despite the large size of the tumor, the blood supply from the right coronary artery and the bone formation.
  • [MeSH-major] Calcinosis / complications. Cardiomyopathies / complications. Heart Neoplasms / complications
  • [MeSH-minor] Cardiac Surgical Procedures / methods. Coronary Angiography. Diagnosis, Differential. Heart Atria. Humans. Male. Middle Aged. Myxoma. Tomography, X-Ray Computed

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  • (PMID = 18445263.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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51. Miller DV, Tazelaar HD: Cardiovascular pseudoneoplasms. Arch Pathol Lab Med; 2010 Mar;134(3):362-8
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  • CONTEXT: Primary cardiac tumors are rare and the great majority are benign neoplasms.
  • Mass-forming reactive and pseudoneoplastic growths are less common, but recognizing and distinguishing these lesions from the neoplasms they resemble is critical to appropriate patient care.
  • OBJECTIVE: The general clinical, imaging, gross pathologic, and histologic features of 5 important pseudoneoplasms (inflammatory myofibroblastic tumor, hamartoma of mature cardiac myocytes, mesothelial/monocytic cardiac excrescences, calcified amorphous tumor, and lipomatous hypertrophy of the atrial septum) are discussed, with an emphasis on features differentiating them from other benign and malignant tumors.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Heart Diseases / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Arch Pathol Lab Med. 2010 Nov;134(11):1584-6 [21043810.001]
  • (PMID = 20196664.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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52. Syed IS, Feng D, Harris SR, Martinez MW, Misselt AJ, Breen JF, Miller DV, Araoz PA: MR imaging of cardiac masses. Magn Reson Imaging Clin N Am; 2008 May;16(2):137-64, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR imaging of cardiac masses.
  • Cardiac MR imaging is the preferred method for assessment of cardiac masses.
  • A comprehensive cardiac MR imaging examination for a cardiac mass consists of static morphologic images using fast spin-echo sequences, including single-shot techniques, with T1 and T2 weighting and fat suppression pulses as well as dynamic imaging with cine steady-state free precession techniques.
  • Specific cardiac tumoral characterization is possible in many cases.
  • When specific tumor characterization is not possible, MR imaging often can demonstrate aggressive versus nonaggressive features that help in differentiating malignant from benign tumors.
  • [MeSH-major] Heart Diseases / diagnosis. Heart Neoplasms / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 18474324.001).
  • [ISSN] 1064-9689
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 91
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53. Burke A, Li L, Kling E, Kutys R, Virmani R, Miettinen M: Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol; 2007 Jul;31(7):1115-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death.
  • Cardiac tumors other than myxomas are rare.
  • All tumors were surgical resections, except 1 tumor that resulted in sudden coronary death and that was diagnosed at autopsy, and 1 tumor that embolized into the coronary artery and was treated by cardiac transplant.
  • Two tumors, present in the aortic and mitral valves, respectively, caused cardiac ischemia.
  • The tumors were polypoid or filiform and histologically resembled inflammatory myofibroblastic tumors of extracardiac sites, with loose spindle cell growth with sparse inflammation.
  • Although there were frequent collagen bundles interspersed among the tumor cells, there were no large areas of dense fibrosis.
  • Long-term follow-up in 2 patients demonstrated no evidence of disease or recurrence.
  • Although metastatic potential was not identified, these tumors may result in serious symptoms, including myocardial infarct, syncope, and sudden death.
  • These cardiac myofibroblastic tumors are readily distinguished from other endocardial-based cardiac tumors, including papillary fibroelastoma and myxoma, which may present clinically in the same manner.
  • [MeSH-major] Death, Sudden / pathology. Granuloma, Plasma Cell / pathology. Heart Diseases / pathology. Myocardial Infarction / pathology. Syncope / pathology


54. Dimassi A, Dimassi W, Arnaout MS: Giant right ventricular fibroma co-existing atrial septal defect in a 15 year old girl. Cardiol Young; 2009 Dec;19(6):630-2
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  • The most common benign cardiac tumours are the myxomas, the rhabdomyomas, and the fibromas, with the latter 2 variants being the most common tumours encountered in children.
  • The size and location of tumours within the heart create a variety of clinical findings, such as murmurs, chest pain, tachyarrythmias, and congestive cardiac failure.
  • Nowadays, the tumours are usually diagnosed by echocardiography, magnetic resonance imaging and cardiac catheterization.
  • Surgical excision is the treatment of choice if the tumour causes either arrhythmia or cavitary obstruction.
  • [MeSH-major] Fibroma / complications. Heart Neoplasms / complications. Heart Septal Defects, Atrial / complications
  • [MeSH-minor] Adolescent. Contrast Media. Diagnosis, Differential. Echocardiography. Electrocardiography. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19835654.001).
  • [ISSN] 1467-1107
  • [Journal-full-title] Cardiology in the young
  • [ISO-abbreviation] Cardiol Young
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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55. Chamsi-Pasha MA, Anwar AM, Al-Nasser I, Nosir YF, Ajam A, Chamsi-Pasha H: Imaging of ventricular septal tumor in an asymptomatic adolescent using multiple modalities. Echocardiography; 2009 May;26(5):581-5
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  • [Title] Imaging of ventricular septal tumor in an asymptomatic adolescent using multiple modalities.
  • Primary cardiac tumors are rare at all ages, and especially so in childhood, where the most prevalent type of benign cardiac masses are rhabdomyomas followed by fibromas, both of which have a predilection for ventricular septum.
  • We report an unusual case of a tumor involving the ventricular septum in an asymptomatic 17-year-old adolescent who has been known to have this tumor for 10 years.
  • The use of multiple imaging included myocardial contrast two-dimensional echocardiography, real time three-dimensional echocardiography (with and without myocardial contrast), and magnetic resonance imaging supported the diagnosis of cardiac rhabdomyoma.
  • [MeSH-major] Diagnostic Imaging / methods. Heart Neoplasms / diagnosis. Heart Septum / pathology. Heart Septum / ultrasonography. Subtraction Technique

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  • (PMID = 19452611.001).
  • [ISSN] 1540-8175
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Riberi A, Gariboldi V, Grisoli D, Collart F: [Cardiac tumors]. Rev Pneumol Clin; 2010 Feb;66(1):95-103
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  • [Title] [Cardiac tumors].
  • [Transliterated title] Les tumeurs cardiaques.
  • Primary cardiac tumor is a rare disease, with an incidence ranging from 0.001 to 0.03%.
  • Eighty percent of them are benign tumors, and among them 70% are myxomas, the others are: fibroelastoma, rhabdomyoma, fibroma, angioma and lipoma.
  • Primary malignant tumors of heart are in 95% of cases sarcomas, the remaining 5% are lymphomas.
  • Cardiac's metastases are more frequent than primary tumors.
  • Diagnosis is made by echocardiography TAC and MRI.
  • Whereas surgery is indicated in patients with benign tumors, or localised sarcomas, chemotherapy in those with widespread disease and radiotherapy and chemotherapy in lymphoma.
  • Prognosis is excellent in benign cardiac tumor.
  • [MeSH-major] Heart Neoplasms / secondary. Heart Neoplasms / surgery
  • [MeSH-minor] Angiography. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Echocardiography. Humans. Magnetic Resonance Imaging. Myocardium / pathology. Myxoma / diagnosis. Myxoma / pathology. Myxoma / surgery. Prognosis. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Masson SAS.
  • (PMID = 20207301.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 28
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57. Joaquim MR, Braile DM, Arruda MV, Soares MJ: Right atrial lipoma resection and partial reconstruction using bovine pericardium. Rev Bras Cir Cardiovasc; 2009 Apr-Jun;24(2):239-41
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  • The primary heart tumors have an incidence varying from 0.001% to 0.28% of all tumors, reported in necropsies series.
  • Lipoma consists of a benign tumour corresponding to about 8% of all primary heart tumors.
  • When present, the symptoms are related to the size and location of such tumor.
  • We report a case of a 27-year-old man with a lipoma in the right atrium who underwent surgical treatment with tumor resection and partial reconstruction of the right atrium using bovine pericardium.
  • [MeSH-major] Heart Neoplasms / surgery. Lipoma / surgery. Pericardium / transplantation
  • [MeSH-minor] Adult. Animals. Cattle. Heart Atria / surgery. Humans. Male

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  • (PMID = 19768305.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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58. Andriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS, REDUCE Study Group: Effect of dutasteride on the risk of prostate cancer. N Engl J Med; 2010 Apr 01;362(13):1192-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease.
  • Men were eligible for inclusion in the study if they were 50 to 75 years of age, had a prostate-specific antigen (PSA) level of 2.5 to 10.0 ng per milliliter, and had had one negative prostate biopsy (6 to 12 cores) within 6 months before enrollment.
  • RESULTS: Among 6729 men who underwent a biopsy or prostate surgery, cancer was detected in 659 of the 3305 men in the dutasteride group, as compared with 858 of the 3424 men in the placebo group, representing a relative risk reduction with dutasteride of 22.8% (95% confidence interval, 15.2 to 29.8) over the 4-year study period (P<0.001).
  • Overall, in years 1 through 4, among the 6706 men who underwent a needle biopsy, there were 220 tumors with a Gleason score of 7 to 10 among 3299 men in the dutasteride group and 233 among 3407 men in the placebo group (P=0.81).
  • During years 3 and 4, there were 12 tumors with a Gleason score of 8 to 10 in the dutasteride group, as compared with only 1 in the placebo group (P=0.003).
  • The incidence of adverse events was similar to that in studies of dutasteride therapy for benign prostatic hyperplasia, except that in our study, as compared with previous studies, the relative incidence of the composite category of cardiac failure was higher in the dutasteride group than in the placebo group (0.7% [30 men] vs. 0.4% [16 men], P=0.03).
  • CONCLUSIONS: Over the course of the 4-year study period, dutasteride reduced the risk of incident prostate cancer detected on biopsy and improved the outcomes related to benign prostatic hyperplasia. (ClinicalTrials.gov number, NCT00056407. )
  • [MeSH-major] 5-alpha Reductase Inhibitors. Azasteroids / therapeutic use. Enzyme Inhibitors / therapeutic use. Prostatic Hyperplasia / drug therapy. Prostatic Neoplasms / prevention & control
  • [MeSH-minor] Aged. Biopsy. Double-Blind Method. Dutasteride. Erectile Dysfunction / chemically induced. Heart Failure / chemically induced. Humans. Male. Middle Aged. Prostate / pathology. Prostate-Specific Antigen / blood. Protein Isoforms. Risk. Treatment Outcome

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  • [Copyright] 2010 Massachusetts Medical Society
  • [CommentIn] Eur Urol. 2010 Oct;58(4):631-2 [20848747.001]
  • [CommentIn] Eur Urol. 2010 Aug;58(2):313 [20845544.001]
  • [CommentIn] N Engl J Med. 2010 Aug 19;363(8):793-4; author reply 794-5 [20842789.001]
  • [CommentIn] N Engl J Med. 2010 Aug 19;363(8):794; author reply 794-6 [20842790.001]
  • [CommentIn] Curr Urol Rep. 2010 Sep;11(5):296-8 [20556555.001]
  • [CommentIn] Eur Urol. 2010 Sep;58(3):465-6 [20845542.001]
  • [CommentIn] N Engl J Med. 2010 Apr 1;362(13):1237-8 [20357287.001]
  • [CommentIn] N Engl J Med. 2010 Aug 19;363(8):793; author reply 794-5 [20718671.001]
  • [CommentIn] Evid Based Med. 2010 Aug;15(4):119-20 [20530608.001]
  • [CommentIn] Eur Urol. 2010 Aug;58(2):312 [20845533.001]
  • (PMID = 20357281.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00056407
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5-alpha Reductase Inhibitors; 0 / Azasteroids; 0 / Enzyme Inhibitors; 0 / Protein Isoforms; EC 3.4.21.77 / Prostate-Specific Antigen; O0J6XJN02I / Dutasteride
  • [Investigator] Bogado H; Borghi M; Casabé A; Juaneda R; Kobelinsky M; Mazza O; Metrebián S; Villaronga A; Costello A; Gardiner RF; Love C; Lynch WJ; Millard R; Nicol D; Stricker P; Sutherland P; Woo H; Wood S; Yaxley J; Bartsch G; Marberger M; Schmidbauer C; Studler G; Gres A; Strockyi A; Ackaert K; Boeckx G; Naudin M; Oosterlinck W; Roumeguère T; Schulman C; Tombal B; Van Erps P; Van Poppel H; Van Velthoven R; Vossaert P; Abdo JA; Atta G; Chaves O; Damião R; Koff W; Saber G; Telöken C; Alexandrov E; Mladenov D; Neykov K; Panchev P; Petkova L; Saltirov I; Aaron L; Abara E; Abramovitch A; Andreou C; Barkin J; Bell D; Bryniak S; Casey R; Chetner M; Cronje D; Dagenais L; Di Costanzo G; Egerdie RB; Eiley D; Flax S; Fleshner N; Gleave M; Goldfarb B; Jansz GK; Kinahan T; Klotz L; Kuzmarov I; Lacombe L; Lee J; Liquornik M; Love W; Maillete A; Morris B; Nickel JC; Okafo B; Paradis JB; Patrick A; Pliamm L; Pommerville P; Saad F; Simard J; Steinhoff G; Tanguay S; Tessier J; Valiquette L; Velji A; Zadra J; Huidobro Alvarado C; Lira Lueje M; Orellana N; Salazar A; Kraus O; Kjaer TB; Mommsen S; Nordling J; Arpo HE; Zirel U; Hellstrom P; Isotalo T; Kauppinen R; Laato M; Leppilahti M; Lukkarinen O; Permi J; Petas A; Rauvala M; Salo J; Taari K; Tammela T; Tuhkanen K; Al Youssef J; Allard P; Alno L; Ayed M; Baron JC; Benraid N; Billebaud T; Bittard H; Bladou F; Boccon-Gibod L; Bocquillon V; Bothorel P; Botto H; Boutin JM; Brunet P; Cadi PO; Chebil M; Colombel M; Colomes G; Defourmestraux N; Descamps F; Desgrandchamps F; Devonec M; Dufeuil P; Horchani A; Hurel JP; Iborra F; Ibrahim H; Lamotte F; Lan O; Le Portz B; Lepelley M; Lesur P; Levigne F; Loulidi S; Marc B; Masson J; Mege JL; Mhiri MN; Monod P; Mosbah AT; Mottet N; Pagès A; Perez G; Rabut B; Rischmann P; Soton G; Teillac P; Tremeaux JC; Turblin JM; Valton M; Villamizar J; Villena P; Villers A; Younes E; Bakir S; Bauer HW; Bauer L; Behrendt U; Benedic M; Benush T; Berberich H; Berse M; Binder M; Bischoff W; Bluemlein HM; Boehle A; Boergmann H; Bohnenkamp A; Boness J; Brands F; Braun HC; Bruns T; Bruske T; Buecherl R; Decker M; Degen S; Demmler I; Dierkopf W; Dubiel J; Eckert R; Eichler U; Farahmandi R; Fehsel F; Frankenau P; Fuhrberg J; Girke C; Glass M; Gleissner J; Graf C; Gratzke P; Groeschel P; Haas W; Hagel WC; Hamann M; Hechelmann W; Heidrich A; Heisler M; Helmbrecht J; Henke G; Henschel T; Hentschke T; Herrmann B; Herrmann K; Herzig J; Himstedt HW; Hofer J; Hoffmann M; Hollberg H; Hübner A; Hudemann B; Jacobi G; Jansen H; Johann KU; Karras R; Karstedt H; Keipert D; Kellner T; Kennerknecht M; Kern J; Klammert R; Köferl F; Konert J; Köttig T; Kriegmair M; Kube U; Kublanck A; Kuehne A; Kuetgens P; Kühn SH; Kühne F; Kunz J; Kutscher KR; Kwela M; Laag R; Langer KC; Langhorst W; Laval KU; Leonhard W; Lock UC; Lunz C; Malsy-Mink P; Marin J; Markow M; Massek F; Matz U; Meisel J; Mertins B; Michel W; Miersch WD; Mohr S; Müller B; Müller D; Müller H; Mumperow E; Münch A; Nette U; Netzer M; Neubauer H; Nietzsch D; Ostwald R; Pauthner H; Petry A; Pielmeier T; Plate H; Ploss HJ; Quack T; Quast D; Radlmaier M; Radulescu M; Rehm B; Renner P; Rollenhagen AR; Romitan-Baum R; Rompf M; Rothe P; Rotter C; Rüssel C; Rüth J; Sablotny J; Schachschneider H; Schäning M; Schaub W; Scheffler M; Scheunpflug K; Schewe J; Schlichter A; Schmidt JJ; Schmidt PS; Schneider B; Schneider J; Schneider T; Schreieer H; Schroeder A; Schrötter U; Schulz T; Schulze M; Schwegmann A; Simson G; Sippel F; Solga M; Speck T; Stahl HD; Surrey HW; Szymula S; Telle J; Thomas S; Uellendahl K; Umbreit O; Unger U; von Keitz A; von Kügelgen T; von Ostau C; Wächter S; Walter T; Warnack W; Weck B; Weitz P; Weizert P; Wengler R; Willgerodt J; Winter M; Wurschi M; Zellner M; Ziegner D; Ziemacki A; Zillmann R; Zürner T; Barbalias G; Hatzichristou D; Kalafatis P; Karanastasis D; Katsifotis H; Kokotas N; Liatsikos E; Malovrouvas D; Margaritopoulou A; Melekos M; Poulias I; Salpigidis G; Sofikitis N; Sofras F; Touloupidis S; Tsidavis A; Fehér J; Kisbenedek L; Romics I; Fitzpatrick J; McDermott TE; Sweeney P; Bercovich E; Caggiano S; D'Armiento M; DiSilverio F; LaRosa P; Manieri C; Mensi M; Montrosi F; Motta M; Pagliarule A; Pecoraro G; Raciti G; Selli C; Usai E; Usai P; Akaza H; Nakatsu H; Sagiyama K; Sakai H; Sakamoto S; Tsukamoto T; Dale R; Gilis D; Gordins S; Hohlovs A; Karulis A; Vjaters E; Bekeris T; Cerniauskiene A; Gaizauskas S; Jankevicius F; Jievaltas M; Palaikiene Z; Stakenas A; Ulys A; Calderon Ferro F; Calvo-Domínguez D; Carvajal-García R; Feria-Bernal G; Lugo-Nevarez MA; Manzanilla-Garcia HA; Martínez-Castro MA; Pacheco-Gahbler C; Rodriguez-Rivera JA; Barten EJ; Blitz W; Cornel EB; de Bruin MJ; de Lange DC; Kil PJ; Koldewijn EL; Kropman RF; Kupfer HW; Leenarts JA; Mulders PF; Schrier BP; Schröder FH; Timmer EC; van Andel G; Van Aubel OG; van Balken MR; van Berkel JT; van Haarst EP; van Vierssen T; Oncko B; Vergunst H; Vijverberg PL; Bary P; Davidson P; Gilling P; Meffan P; Nixon T; Tuckey J; Andersen M; Beisland HO; Bjerklung J; Truls E; Hoeg OM; Øgreid P; Omland H; Borkowski A; Duda W; Galezia M; Jarzemski P; Kwiatkowski S; Meller J; Mikszewica A; Niezabitowski J; Roslan M; Sikorski A; Sokolowski J; Szkarlat K; Tereszkiewicz J; Pinheiro JC; Pinheiro LC; de Oliveira AF; Días JR; Gomes C; Guimarães M; Ferreira AM; Monteiro H; Pires MB; Rolo F; Morales-Ramírez JO; Ambert V; Bina MN; Calomfirescu N; Aljaev Y; Al-Shukri S; Apolikhin O; Gorilovsky L; Grigoriev M; Krupin V; Lopatkin N; Mazo E; Petrov S; Shaplygin L; Breza J; Kliment J; Bizjak I; Kisner K; Sedmak B; Vodopija N; Bongers M; Glocer J; Haffejee M; Harden P; Heyns C; Mackenzie T; Reif S; Van der Walt JS; Webb G; Astobieta A; Azparren J; Benejam J; Cabezudo I; Castiñeiras J; Chéchile Toniolo G; Cuya L; Díaz JL; Franco E; Gallego Sánchez JA; Galvis Palau F; Garcia Matres MJ; García Pérez M; Gelabert Mas A; Gimeno Collado A; Hevia Suarez M; Kilani Elmasri S; Llorente C; López Alcina E; Lopez-Alda A; Lorente Garin JA; Morales AM; Martinez Javaloyas J; Martinez-Sagarra Oceja JM; Martin-Marquina Aspiunza A; Montesino M; Morales Lopez A; Morote J; Mouaffak N; Nogueras MA; Paños Lozano P; Pedro; Pastor Sempere F; Rodriguez P; Romero J; Saladie JM; Sanchez Chapado M; Sanz Jaca JP; Serrallach Milá N; Silmi Moyano A; Solsona E; Tallada Buñuel M; Teba del Pino F; Unda Urzaiz M; Villavicencio H; Zaragoza J; Damber JE; Folmerz P; Gedda S; Magnusson B; Norming U; Paradis A; Pileblad E; Sandin T; Schain M; Stattin P; Ströberg P; Wagrell L; Waldén M; Mauritz; Wang YH; Willén M; Eberle J; Eigenmann J; Gunst M; Gygi C; Heering F; Michaelis WE; Mottax A; Recker F; Rochat CH; Trinkler F; Akdas A; Atan A; Ozcan F; Ozen H; Abdulhakim E; Akhtar M; Anderson C; Barnes D; Carter P; Chinegwundoh F; Cole O; Cumming J; Donnachie H; Emberton M; Fraser J; Gillatt D; Gonzalez V; Govindraj S; Hamilton G; Hehir M; Jaganathan R; Jassel G; Javle PM; Kaisary A; Kanagasundaram S; Khursheed M; Leung H; Liu S; MacDermott J; Maroni J; Martin R; Matanhelia SS; McClinton S; McFarlane J; McInerney P; McNeill SA; McNicholas T; Meddings R; Mellon J; Miller P; O'Reilly P; Paul A; Pavel I; Pawa R; Perrapato S; Persad R; Philp T; Pickard R; Pttman W; Pitts C; Pocock R; Puri R; Raja A; Rao P; Robinson J; Robinson J; Saeed I; Salman M; Sarmiento R; Schwaibold H; Sethia K; Sharma N; Shaw H; Speakman M; Taylor S; Thomas H; Lesovoy V; Adams G; Altman D; Andriole G; Apaydin A; Aronson W; Auerback S; Baier C; Bailen J; Baker W; Bannow J; Bardot S; Barham R; Barkley C; Barnswell C; Basler J; Bass J; Baum N; Baumann L; Beam T; Belkoff L; Benaim E; Benitez O; Bergner D; Bergreen P; Bernstein G; Bernstein M; Bidair M; Blath R; Bobrowski J; Bock D; Bondhus M; Bowling B; Bracken RB; Brawer M; Brodak P; Broker R; Brooks S; Brosman S; Brown D; Brown G; Brown J; Bruno D; Bryant K; Bundrick WS; Burke WR; Camps J Jr; Capo J Jr; Castellanos R; Chang S; Childs S; Ching V; Chinn S; Chiou R; Chiura A; Chodak G; Chu F; Chung S; Clark R; Clark W; Cochran J; Cohen J; Cohen S; Cole F; Concepcion R; Cook D; Corman J; Corral D; Costa F; Cowan B; Coyle C; Crawford D; Cudecki J; Daniels M; Davis B; DeFelippo JD; Deichmann R; Diener C; Diokno A; Drehobl M; Dula E; Edelman R; Mitchell; Ellis D; Ellis W; Eure G; Fay R; Fei R; Feldman R; Finkbeiner A; Fishman R; Fitch W; Forrest J; Freedberg P; Freedman S; Freeman J; Fromang D; Galdieri L; Gange S; Gardner T; Garvin D; Gassner L; Gaylis F; Gburek B; Gerber G; Gershman A; Ghavamian R; Gill H; Gittelman M; Gleason D; Gluckman G; Godschalk M; Goldberg K; Green B; Greene G; Greengold R; Grubb R 3rd; Grubman J; Guice S; Hagan M; Hagood P; Hamad M; Hamway S; Harkaway R; Harper W; Harris R; Hatcher P; Henderson R; Hertzman B; Hey W; Hezmall H; Hollowell C; Hoppmann H; Houser E; Hudnall C; Husain A; Igel T; Iliades C; Immergut M; Isen J; Israeli R; Jablonski D; Johnson J; Kaempf M; Kaminetsky J; Kane R; Kaplan M; Kaplinsky R; Karlin G; Karsh L; Katz PG; Kauder D; Kaufman J; Kaufman R; Keanne T; Killorin W; Kistein S; King E; Kleer E; Klimbert I; Klorfein E; Kornitzer G; Koukol S; Kriteman L; Kronhaus R; Lasky R; Lawton S; Levine M; Liberman S; Libin M; Lieber M; Lieberman M; Lipkis D; Lipsitz D; Lochner J; Lubin B; Lugg J; Lynch D; Macaluso J Jr; Maggiacomo F; Mandel E; Manion S; Marks J; Marks L; Mason T; McLeod D; McMurray J; Mehlhaff B; Mellinger B; Menashe D; Miller D; Mirelman S; Mitcheson H; Mobley D; Modarelli R; Mollen M; Monath JR; Monnig W; Moore J; Morgenstern J; Moseley W; Murdock M; Murphy G; Myers R; Naslund M; Nelson J; Neustein P; Niku S; O'Leary M; O'Reilly K; Oselinksky D; Parham R; Parr G; Parries G; Parulkar B; Passarella M; Pathroff R; Patterson T; Peterson A; Pettaway C; Pinto A; Price V; Puopolo A; Rainwater L; Ralph L; Ramos C; Rapo S; Ray P; Reed D; Reese C; Riff D; Ritter H Jr; Roberts B; Roehrborn C; Roper R; Saslawsky M; Sawczuk I; Schiff W; Schwartz E; Sharifi R; Shinohara K; Sidhorn A; Sieber P; Sigman D; Singh E; Sipio J; Slaski A; Slawin K; Slutsky J; Snyder J; Spigner D; Spirnak J; Stallings J; Steidle C; Stein B; Stout D; 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59. Astrinidis A, Henske EP: Mutation detection in tumor suppressor genes using archival tissue specimens. Methods Mol Med; 2006;126:185-96
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  • [Title] Mutation detection in tumor suppressor genes using archival tissue specimens.
  • Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by seizures, mental retardation, and benign tumors of many organs, including the brain, kidneys, skin, retina, and heart.
  • TSC is caused by mutations in the TSC1 and TSC2 tumor suppressor genes.
  • Allelic loss (also called loss of heterozygosity [LOH]) in the 9q34 and 16p13 regions has been found in many tumor types from TSC patients.
  • Cardiac rhabdomyomas are frequently found in infants with TSC.
  • [MeSH-major] DNA Mutational Analysis / methods. Genes, Tumor Suppressor. Mutation / genetics. Tissue Banks

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  • (PMID = 16930013.001).
  • [ISSN] 1543-1894
  • [Journal-full-title] Methods in molecular medicine
  • [ISO-abbreviation] Methods Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
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60. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs.
  • This paper deals with a population-based material collected during the years 1990-1998, and comprises 439 tumours and tumour-like vascular processes from 420 dogs.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • More than one half (242 of 439) occurred in the skin, and a great majority of skin processes (223 of 242) represented benign tumours or tumour-like lesions.
  • The next most common site of summarised lesions was the spleen, with 110 cases, with only 17 processes in this organ being defined as benign.
  • Eleven of 12 heart tumours were angiosarcomas.
  • Most tumour-like proliferations were papillary endothelial hyperplasias.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • Primary metastases were observed in 63 animals, the majority in the spleen and heart.
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-major] Dog Diseases / pathology. Vascular Neoplasms / veterinary

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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61. Aktoz M, Tatli E, Ege T, Yalçin O, Büyüklü M, Aksu F, Gül C, Ozdemir C: Cardiac rhabdomyoma in an adult patient presenting with right ventricular outflow tract obstruction. Int J Cardiol; 2008 Nov 28;130(3):e105-7
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  • [Title] Cardiac rhabdomyoma in an adult patient presenting with right ventricular outflow tract obstruction.
  • We present a 24 year old woman with cardiac rhabdomyoma.
  • Cardiac rhabdomyoma is the most common benign cardiac tumor in infants, but in adults, cardiac rhabdomyoma is very rare.
  • These tumors are often spontaneously reversible because they are associated to the right or left ventricular outflow tract obstruction, tachyarrhythmias and heart failure where surgery is necessary.
  • [MeSH-major] Heart Neoplasms / diagnosis. Rhabdomyoma / diagnosis. Ventricular Outflow Obstruction / diagnosis

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  • (PMID = 17727983.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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62. Dorobantu M, Fruntelata A, Constantinescu D, Racoveanu I, Ardeleanu C, Tatu-Chitoiu G, Lazar IC: Primary left heart malignant fibrous histiocytoma. Eur J Echocardiogr; 2005 Jun;6(3):225-7
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  • [Title] Primary left heart malignant fibrous histiocytoma.
  • We present the case of a 53 years-old woman presenting with congestive heart failure and pleural and pericardial effusions, in whom transthoracic and transesophageal echocardiography revealed multilocular cardiac tumor involving the left atrium wall, extending into the pericardium.
  • Tumor was excised surgically and proved to be a malignant fibrous histiocytoma, primarily confined to the heart.
  • This is the 47th case of primary cardiac fibrous malignant histiocytoma reported in the literature.
  • Echocardiography was the method of diagnosis before rapid referral to surgery.
  • [MeSH-major] Echocardiography. Heart Neoplasms / ultrasonography. Histiocytoma, Benign Fibrous / ultrasonography
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 15894243.001).
  • [ISSN] 1525-2167
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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63. Sparrow PJ, Kurian JB, Jones TR, Sivananthan MU: MR imaging of cardiac tumors. Radiographics; 2005 Sep-Oct;25(5):1255-76
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  • [Title] MR imaging of cardiac tumors.
  • Magnetic resonance (MR) imaging is an important tool in the evaluation of cardiac neoplasms.
  • Recent improvements in pulse sequences for cardiac MR imaging have led to superior image quality, with reduced motion artifact and improved signal-to-noise ratio and tissue contrast.
  • Although there is some overlap in the MR imaging appearances of cardiac tumors, particularly of primary malignancies, differences in characteristic locations and features should allow confident differentiation between benign and malignant tumors.
  • Indicators of malignancy at MR imaging are invasive behavior, involvement of the right side of the heart or the pericardium, tissue inhomogeneity, diameter greater than 5 cm, and enhancement after administration of gadolinium contrast material (as a result of higher tissue vascularity).
  • Concomitant pericardial or pleural effusions are rare in benign processes but occur in about 50% of cases of malignant tumors.
  • MR imaging offers improved resolution, a larger field of view, and superior soft-tissue contrast compared with those of echocardiography, suggesting that knowledge of the MR imaging features of cardiac neoplasms is important for accurate diagnosis and management.
  • [MeSH-major] Heart Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Myxoma / diagnosis

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  • [Copyright] (c) RSNA, 2005.
  • (PMID = 16160110.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 84
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64. Kim AY, Kim JS, Yoon Y, Kim EJ: Multidetector computed tomography findings of a papillary fibroelastoma of the aortic valve: a case report. J Korean Med Sci; 2010 May;25(5):809-12
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  • Papillary fibroelastoma is a rare benign cardiac tumor that represents 10% of all primary cardiac tumors.
  • Diagnosis is accomplished incidentally by echocardiography that is usually performed for another purpose.
  • [MeSH-major] Aortography / methods. Fibroma / radiography. Fibroma / surgery. Heart Neoplasms / radiography. Heart Neoplasms / surgery. Papillary Muscles / radiography. Papillary Muscles / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 20436724.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2858847
  • [Keywords] NOTNLM ; Aortic Valve / Echocardiography / Heart Neoplasms / Multidetector CT
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65. Altbach MI, Squire SW, Kudithipudi V, Castellano L, Sorrell VL: Cardiac MRI is complementary to echocardiography in the assessment of cardiac masses. Echocardiography; 2007 Mar;24(3):286-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac MRI is complementary to echocardiography in the assessment of cardiac masses.
  • Despite the fact that the incidence of cardiac tumors is low, the prompt evaluation and adequate intervention of these is highly important.
  • Although most tumors of the heart are considered histologically benign, there are significant risks associated with these "benign" tumors.
  • With the advent of noninvasive imaging modalities--traditionally echocardiography; but more recently using cross-sectional imaging with cardiac computed tomography and magnetic resonance imaging--cardiac tumors can be optimally assessed providing a greater opportunity for curative treatments by cardiothoracic surgery.
  • [MeSH-major] Echocardiography / methods. Heart Neoplasms / diagnosis. Heart Neoplasms / ultrasonography. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Prevalence

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  • (PMID = 17313646.001).
  • [ISSN] 0742-2822
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 73
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66. Hohenstein C, Herdtle S: Unexpected death from a colloid cyst. Int J Emerg Med; 2010;3(1):65-6
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  • BACKGROUND: Colloid cysts are usually benign brain tumors, which rarely cause acute neurological deterioration with sudden death due to an acute increase of intracranial pressure.
  • RESULTS: He unexpectedly developed a generalized seizure, acute pulmonary edema and life-threatening cardiac dysrhythmia.
  • CONCLUSION: Subtle distinctions between symptoms due to intracranial hypertension, which typically cause headache and vomiting, and true gastroenteritis are discussed as well as the pathophysiology of neurogenic pulmonary edema and the origin of cerebral-triggered cardiac dysrhythmias.

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  • (PMID = 20414387.001).
  • [ISSN] 1865-1380
  • [Journal-full-title] International journal of emergency medicine
  • [ISO-abbreviation] Int J Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2850975
  • [Keywords] NOTNLM ; Cardiopulmonary complication / Colloid cyst / Unexpected death
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67. Rodríguez-Ortega MF, Jacobo-Valdivieso EJ, Flores-Calderón O, Del Sol García-Ortegón M, León-Hernández G, Luna-Saucedo MD: [Papillary cardiac fibroelastoma. An unusual presentation]. Cir Cir; 2007 Jul-Aug;75(4):293-6
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  • [Title] [Papillary cardiac fibroelastoma. An unusual presentation].
  • [Transliterated title] Fibroelastoma papilar cardiaco. Una inusual presentación.
  • BACKGROUND: Papillary fibroelastoma is a rare benign tumor characterized morphologically since first being described in 1976.
  • Nevertheless, this tumor can be presented with a variety of clinical manifestations, making diagnosis challenging for the physician.
  • CASE REPORT: We report the case of a male patient with a history of type 2 diabetes mellitus and arterial hypertension who was admitted to the hospital with a diagnosis of ischemic heart disease accompanied by sustained ventricular tachycardia.
  • Echocardiogram reported degree I diastolic dysfunction, apical ventricular aneurysm, and unusual apical tumor of the septum and left ventricle.
  • DISCUSSION: Primary heart tumors have an incidence of 0.0017%.
  • Diagnosis is accomplished incidentally by echocardiography, which is usually carried out for other reasons.
  • Surgical procedure of choice is total tumor resection along with valve repair or replacement, if necessary, and in some cases cardiac endothelium resection and repair, with or without pericardium patch replacement.
  • [MeSH-major] Fibroma / diagnosis. Heart Neoplasms / diagnosis

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  • (PMID = 18053362.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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68. Pucci A, Valori A, Muscio M, Garofalo L, Ferroni F, Abbruzzese PA: Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. Cardiovasc Pathol; 2009 May-Jun;18(3):187-90
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  • [Title] Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature.
  • BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion, mainly occurring in children and young adults and extremely rare in the heart.
  • Cardiac IMTs are considered biologically benign, but they may have fatal consequences depending upon the peculiarity of site.
  • Because of their rarity in the heart, most knowledge is based on extracardiac lesions that have uncertain behaviour.
  • After complete surgical excision of the tumor, the patient is disease-free at 1 year of follow-up.
  • Immunohistochemistry was helpful for characterization and differential diagnosis.
  • The immunoreactivity pattern (including calponin expression) was similar to that of extracardiac IMTs except for anaplastic lymphoma kinase 1 immunoreactivity, lacking in this benign intracardiac IMT but usually associated to favourable prognosis in extracardiac IMTs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Heart Neoplasms / pathology. Immunohistochemistry. Inflammation / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Cardiac Surgical Procedures. Diagnosis, Differential. Humans. Infant. Male. Treatment Outcome

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  • (PMID = 18436455.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 17
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69. Ahuja JR, Amonkar GP, Deshpande J: Papillary fibroelastoma of the heart. Indian J Pathol Microbiol; 2008 Oct-Dec;51(4):559-60
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  • [Title] Papillary fibroelastoma of the heart.
  • Primary intra-cardiac tumors are rare.
  • Most of them are benign.
  • Of the benign tumors, myxomas are the most common.
  • PFE is a relatively rare benign tumor of the heart.
  • It occurs commonly on cardiac valves and is often an incidental finding.
  • It is important to be aware of this entity because even though it is benign it may present with life-threatening complications, which are well documented in literature.
  • Surgery is the treatment of choice for these tumors.
  • We present the case of a 30-year-old male in whom PFE was an incidental finding.
  • [MeSH-major] Aortic Valve / pathology. Fibroma / pathology. Heart Neoplasms / pathology. Heart Valve Diseases / pathology. Papillary Muscles / pathology

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  • (PMID = 19008597.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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70. Irani AD, Estrera AL, Buja LM, Safi HJ: Biatrial myxoma: a case report and review of the literature. J Card Surg; 2008 Jul-Aug;23(4):385-90
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  • BACKGROUND: In surgical series, a majority of benign cardiac tumors are myxomas.
  • METHODS: The tumor was removed surgically via a midline sternotomy using cardiopulmonary bypass.
  • Both left and right atrial extensions of the tumor mass were removed.
  • [MeSH-major] Heart Neoplasms / surgery. Myxoma / surgery
  • [MeSH-minor] Heart Atria. Humans. Male. Middle Aged

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  • (PMID = 18384573.001).
  • [ISSN] 0886-0440
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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71. Kajihara N, Tanoue Y, Eto M, Tomita Y, Masuda M, Morita S: Surgical experience of cardiac tumors: early and late results. Surg Today; 2006;36(7):602-7
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  • [Title] Surgical experience of cardiac tumors: early and late results.
  • PURPOSE: Cardiac tumors include benign and malignant neoplasms that arise within the cardiac chambers or myocardium.
  • This study summarizes our surgical experiences with cardiac tumors.
  • METHODS: Between 1975 and 2003, 51 patients with cardiac tumors were surgically treated.
  • Forty-seven cardiac myxomas were excised in 46 patients with an average age of 51.7 +/- 18 years.
  • The preoperative symptoms included congestive heart failure (37%) and embolism (30%).
  • Benign nonmyxomatous tumors.
  • Three patients with a mean age of 26.3 +/- 19.0 years showed benign nonmyxomatous tumors.
  • Malignant tumors.
  • Two patients were diagnosed to have malignant tumors and although there was no perioperative death, both died postoperatively within 6 months.
  • CONCLUSIONS: Cardiac myxomas and nonmyxomatous benign cardiac tumors show excellent results after a surgical excision, with a low morbidity and mortality.
  • A surgical resection should thus be considered as a treatment option for patients with malignant tumors.
  • [MeSH-major] Heart Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cardiac Surgical Procedures / methods. Child, Preschool. Embolism / etiology. Female. Heart Failure / etiology. Humans. Male. Middle Aged. Myxoma / mortality. Myxoma / surgery

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  • (PMID = 16794794.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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72. Yagdi T, Sharples L, Tsui S, Large S, Parameshwar J: Malignancy after heart transplantation: analysis of 24-year experience at a single center. J Card Surg; 2009 Sep-Oct;24(5):572-9
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  • [Title] Malignancy after heart transplantation: analysis of 24-year experience at a single center.
  • BACKGROUND: Malignancy is an important complication after heart transplantation.
  • METHODS: Data for 835 patients who underwent heart transplantation between 1979 and 2002 and survived beyond one month were retrospectively evaluated for posttransplant skin cancer, solid organ tumors, and lymphoma.
  • Skin cancer, solid organ tumors, and lymphoma represented 49%, 27%, and 24% of the malignancies, respectively.
  • Mean patient age at transplantation for patients developing skin cancer, solid organ tumor, and lymphoma were 50 years, 51 years, and 46 years, respectively (p = 0.024).
  • Median survival after diagnosis of skin cancer, solid organ tumor, and lymphoma were 5.0 years, 0.3 years, and 0.7 years, respectively (p < 0.001).
  • Older age at transplantation, smoking history, and more episodes of treated rejection were related to increased incidence of nonlymphoid malignancy incidence after heart transplantation, whereas no variable was associated with lymphoid malignancy.
  • Skin cancers have a benign course, while solid organ malignancies and lymphomas carry an unfavorable prognosis.
  • [MeSH-major] Heart Transplantation / adverse effects. Kidney Neoplasms / etiology. Lymphoma / etiology. Skin Neoplasms / etiology


73. Ivanovic B, Tadic M, Matic D, Simic D: Right ventricular myxoma obstructing the outflow tract. Am Heart Hosp J; 2010;8(2):E118-21
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  • Cardiac myxomas are benign tumors of endocardial origin.
  • Symptoms might mimic heart disease as well as infectious disease, immunodeficiency, and malignant processes.
  • She presented clinically with syncope, systolic murmur, and signs of right heart failure.
  • The diagnosis of the right ventricular tumor was based on 2D echocardiography, magnetic resonance, and multislice computed tomography findings.Emergency surgical excision of the myxoma was necessary to prevent embolism and sudden death.
  • [MeSH-major] Heart Neoplasms / complications. Myxoma / complications. Ventricular Outflow Obstruction / etiology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 21928178.001).
  • [ISSN] 1751-7168
  • [Journal-full-title] The American heart hospital journal
  • [ISO-abbreviation] Am Heart Hosp J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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74. Sydow K, Willems S, Reichenspurner H, Meinertz T: Papillary fibroelastomas of the heart. Thorac Cardiovasc Surg; 2008 Feb;56(1):9-13
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  • [Title] Papillary fibroelastomas of the heart.
  • Cardiac papillary fibroelastomas (CPFs), the second most common primary cardiac tumor, are benign endocardial papillomas predominantly affecting the cardiac valves.
  • Although CPFs are rare and benign tumors, they may result in life-threatening complications.
  • Early diagnosis of this condition is important, since it represents a surgically correctable cause of systemic embolism, myocardial infarction, stroke, acute valve dysfunction, and sudden cardiac death.
  • This review summarizes the significance and clinical approach for the diagnosis of this cardiac entity.
  • The differential diagnosis, histological characteristics of CPF and current treatment strategies are also discussed.
  • [MeSH-major] Fibroma. Heart Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Heart Valves. Humans

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  • (PMID = 18200460.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 77
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75. Kuroczynski W, Hake U, Pruefer D, Peivandi A, Heinemann M, Oelert H: Aortic valve papillary fibroelastoma. J Heart Valve Dis; 2005 Jan;14(1):140-2
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  • Cardiac papillary fibroelastoma (CPF) is a rare primary benign cardiac tumor.
  • Before the use of echocardiography, the lesion was identified at autopsy or incidentally during cardiac surgery.
  • CPF is the third most common primary cardiac tumor after atrial myxoma and lipoma, and is the most common tumor of the valvular endothelium.
  • Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) permit diagnosis of the tumor in living patients.
  • CPF may be the cause of cerebrovascular or cardiac ischemia due to embolization or occlusion of the vascular ostia.
  • Embolic material may arise from fragments of the tumor itself, or from surrounding thrombus.
  • The case is reported of a patient with CPF of the aortic valve in whom TEE diagnosis was conducted and the tumor removed surgically.
  • [MeSH-major] Aortic Valve / ultrasonography. Fibroma / ultrasonography. Heart Neoplasms / ultrasonography. Papillary Muscles / ultrasonography

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  • (PMID = 15700449.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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76. Kawano Y, Tamura A, Goto Y, Shinozaki K, Zaizen H, Kadota J: Incidental detection of cancers and other non-cardiac abnormalities on coronary multislice computed tomography. Am J Cardiol; 2007 Jun 1;99(11):1608-9
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  • [Title] Incidental detection of cancers and other non-cardiac abnormalities on coronary multislice computed tomography.
  • The investigators prospectively examined 625 consecutive patients who underwent coronary multislice computed tomography (MSCT) for suspected coronary artery disease (CAD) and evaluated the presence or absence of cancers and other noncardiac abnormalities on the original transverse sectional images of MSCT.
  • The remaining 617 patients (344 men, 273 women; mean age 66 +/- 12 years) were analyzed.
  • In addition, nonmalignant abnormalities (nodules, tumors, or lymphadenopathies) were also found in 142 patients (23.01%), consisting of 58 postinflammatory lung nodules (9.40%), 49 hepatic cysts or hemangiomas (7.94%), 18 benign thyroid tumors (2.92%), 12 mediastinal lymphadenopathies (1.94%), 4 benign mammary gland tumors (0.65%), and 1 esophageal submucosal tumor (0.16%).
  • [MeSH-major] Coronary Artery Disease / radiography. Incidental Findings. Neoplasms / pathology. Neoplasms / radiography. Tomography, X-Ray Computed


77. Mariscalco G, Bruno VD, Borsani P, Dominici C, Sala A: Papillary fibroelastoma: insight to a primary cardiac valve tumor. J Card Surg; 2010 Mar;25(2):198-205
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  • [Title] Papillary fibroelastoma: insight to a primary cardiac valve tumor.
  • Papillary fibroelastomas are rare benign cardiac tumors.
  • The pathophysiology and management of these tumors is the subject of this review.
  • [MeSH-major] Fibroma / etiology. Fibroma / surgery. Heart Neoplasms / etiology. Heart Neoplasms / surgery
  • [MeSH-minor] Cardiac Surgical Procedures. Diagnosis, Differential. Echocardiography. Heart Valves. Humans

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  • (PMID = 20149002.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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78. García Rinaldi R, Pérez Hernández J, Corbalá AR, Aponte HR, Dayán V, Plaza M: Surgical treatment of multiple intracardiac and pulmonary artery tumor implants embolic from uterine intravascular leiomyomatosis. Bol Asoc Med P R; 2007 Jan-Mar;99(1):51-5
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  • [Title] Surgical treatment of multiple intracardiac and pulmonary artery tumor implants embolic from uterine intravascular leiomyomatosis.
  • Intravenous uterine leiomyomatosis is the invasion of the para-uterine veins by bundles of benign uterine muscle.
  • These muscle bundles can grow and extend directly to pelvic organs or embolize to the right cardiac chambers or pulmonary artery.
  • Patients presenting with cardiac tumors from intravenous uterine leiomyomatosis must undergo aggressive surgical management to achieve a cure.
  • [MeSH-major] Heart Neoplasms / secondary. Heart Neoplasms / surgery. Leiomyomatosis / pathology. Leiomyomatosis / surgery. Neoplastic Cells, Circulating. Pulmonary Artery. Uterine Neoplasms / pathology

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  • (PMID = 17616048.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Puerto Rico
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79. Connelly EA, Viera M, Price C, Waner M: Segmental hemangioma of infancy complicated by life-threatening arterial bleed. Pediatr Dermatol; 2009 Jul-Aug;26(4):469-72
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  • Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood.
  • Head and neck segmental hemangiomas have a higher risk of causing life-threatening complications and of having associated structural anomalies, i.e., PHACES syndrome (Posterior fossa malformations, hemangiomas, arterial anomalies, coartation of the aorta and other cardiac defects, eye abnormalities and sternal clefting or supra abdominal raphe).
  • [MeSH-major] Head and Neck Neoplasms / complications. Hemangioma / complications. Hemorrhage / etiology. Peripheral Vascular Diseases / etiology. Skin Neoplasms / complications. Skin Ulcer / etiology


80. Tatli S, Lipton MJ: CT for intracardiac thrombi and tumors. Int J Cardiovasc Imaging; 2005 Feb;21(1):115-31
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  • [Title] CT for intracardiac thrombi and tumors.
  • Although cardiac tumors are rare, they nevertheless represent an important subgroup, the diagnosis of which is challenging for the primary care physician.
  • Symptoms are not characteristic and serious complications including stroke, myocardial infarction and even sudden death from arrhythmia may be the first signs of tumor.
  • The most common primary cardiac neoplasm is the benign myxoma and the most frequent primary malignant lesion is sarcoma.
  • Cardiac metastases from distant primary carcinomas are now frequently encountered.
  • Echocardiography and angiocardiography with or without coronary arteriography remain routine methods for evaluating cardiac neoplasms.
  • This chapter reviews the wide spectrum of intracardiac thrombi and tumors including their incidence and imaging characteristics with particular reference to the CT findings and differential diagnosis.
  • [MeSH-major] Coronary Thrombosis / diagnostic imaging. Heart Neoplasms / diagnostic imaging. Myxoma / diagnostic imaging. Sarcoma / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 15915945.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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81. Eftychiou C, Antoniades L: Cardiac hemangioma in the left ventricle and brief review of the literature. J Cardiovasc Med (Hagerstown); 2009 Jul;10(7):565-7
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  • [Title] Cardiac hemangioma in the left ventricle and brief review of the literature.
  • Cardiac hemangiomas are very rare benign cardiac tumors.
  • The natural history of these tumors is unpredictable.
  • Diagnosis is usually made with echocardiography and surgical resection is the treatment of choice.
  • Echocardiography revealed a mobile spherical mass within the left ventricle, whereas left ventriculography showed an intracavity-filling defect without any tumor blushing.
  • The tumor was removed surgically through the left atrium.
  • [MeSH-major] Heart Neoplasms / pathology. Hemangioma, Capillary / pathology
  • [MeSH-minor] Adult. Cardiac Surgical Procedures. Echocardiography, Transesophageal. Heart Ventricles / pathology. Humans. Male. Treatment Outcome

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  • (PMID = 19424078.001).
  • [ISSN] 1558-2027
  • [Journal-full-title] Journal of cardiovascular medicine (Hagerstown, Md.)
  • [ISO-abbreviation] J Cardiovasc Med (Hagerstown)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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82. Jain D, Maleszewski JJ, Halushka MK: Benign cardiac tumors and tumorlike conditions. Ann Diagn Pathol; 2010 Jun;14(3):215-30
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  • [Title] Benign cardiac tumors and tumorlike conditions.
  • Benign primary cardiac tumors and tumorlike conditions are rare, yet important surgical and autopsy pathology specimens.
  • Some cardiac tumors arise in the setting of genetic disorders.
  • Providing the correct diagnosis for a cardiac mass lesion will aid in patient care and genetic counseling.
  • Therefore, a familiarity of these tumors is essential for both surgical and forensic pathologists.
  • It also provides differential diagnoses and key facts to differentiate between similar appearing tumors.
  • [MeSH-major] Fibroma / pathology. Heart Neoplasms / pathology. Myxoma / pathology. Rhabdomyoma / pathology
  • [MeSH-minor] Female. Heart Diseases / pathology. Humans. Male

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  • (PMID = 20471569.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 158
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83. Kontogiorgi M, Exarchos D, Charitos C, Floros I, Rontogianni D, Roussos C, Routsi C: Primary right atrium angiosarcoma mimicking pericarditis. World J Surg Oncol; 2007;5:120
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Primary cardiac neoplasms occur rarely and most of them are benign.
  • Malignant tumors including angiosarcoma are extremely rare and have a non specific clinical presentation and a poor prognosis.
  • Autopsy revealed the mass of the right atrium, which was identified on histological examination as primary cardiac angiosarcoma.
  • CONCLUSION: This case highlights the difficulties both in early diagnosis and in the management of patients with cardiac angiosarcoma.

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  • (PMID = 17953738.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2174942
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84. Alpesh A P, Ebere O C, Daniel S S, Vivek B, Stuart O S, Anastasia A, Aasha S G: A right atrial hemangioma mimicking thrombus in a patient with atrial arrhythmias. Open Cardiovasc Med J; 2007;1:34-5
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  • Cardiac hemangiomas are rare tumors, accounting for only 2.8% of all benign primary cardiac tumors and occur at any age.
  • Clinical presentations vary depending on the tumor location (myocardial, endocardial or pericardial).
  • In many cases, this may be an incidental finding.

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  • [Cites] J Am Soc Echocardiogr. 1997 Jun;10(5):579-81 [9203501.001]
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  • (PMID = 18949089.001).
  • [ISSN] 1874-1924
  • [Journal-full-title] The open cardiovascular medicine journal
  • [ISO-abbreviation] Open Cardiovasc Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2570566
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85. Locci G, Pili A: Ischemic stroke in a young woman with aortic papillary fibroelastoma: echocardiographic diagnosis and surgical excision. Ital Heart J; 2005 Apr;6(4):357-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ischemic stroke in a young woman with aortic papillary fibroelastoma: echocardiographic diagnosis and surgical excision.
  • Papillary fibroelastoma is a benign cardiac tumor typically attached to the cardiac valves.
  • The tumor is recognized during life often in patients evaluated for embolic events of unclear etiology, but sometimes it is recognized in totally asymptomatic patients.
  • The diagnosis was obtained at two-dimensional echocardiography and confirmed at transesophageal echocardiography.
  • The tumor was located in the non-coronary aortic cusp, without aortic regurgitation.
  • The tumor was surgically removed.
  • The biopsy confirmed the diagnosis.
  • This case is an example of a primary intracavitary tumor recognized in a young woman with unclear embolic event.
  • Two-dimensional echocardiography proved to be the exam of choice for the early diagnosis of cardiac tumors.
  • [MeSH-major] Echocardiography, Transesophageal. Fibroma / surgery. Fibroma / ultrasonography. Heart Neoplasms / surgery. Heart Neoplasms / ultrasonography. Stroke / etiology
  • [MeSH-minor] Adult. Aortic Valve / surgery. Aortic Valve / ultrasonography. Cardiac Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Papillary Muscles / pathology. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 15902938.001).
  • [ISSN] 1129-471X
  • [Journal-full-title] Italian heart journal : official journal of the Italian Federation of Cardiology
  • [ISO-abbreviation] Ital Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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86. Fuzellier JF, Brasselet C, Perotin S, Torossian PF, Metz D: Infected multiple fibroelastomas in hypertrophic cardiomyopathy. J Heart Valve Dis; 2005 Nov;14(6):848-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cardiac papillary fibroelastomas are rare benign tumors of the heart with potential for life-threatening complications.
  • Preoperative transesophageal echocardiography is important for detecting all cardiac sites involving this tumor, because excision of all such tumors must be performed to prevent serious complications.
  • [MeSH-major] Cardiomyopathy, Hypertrophic / complications. Endocarditis, Bacterial / complications. Fibroma / complications. Heart Neoplasms / complications. Staphylococcal Infections / complications


87. Mueller OM, van de Nes JA, Wieland R, Schoch B, Sure U: Surgical treatment of primary intracranial myxoma in a child following radiotherapy: case report and review of the literature. Childs Nerv Syst; 2010 Jun;26(6):829-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Myxomas are benign tumors of the mesenchymal origin and account for about half of the benign cardiac tumors.
  • As a secondary neoplasia following radiotherapy, myxoma has only been reported once in the literature.
  • The close relation to the radiation field of the posterior fossa makes it highly suggestive that the myxoma developed as a secondary neoplasia induced by radiotherapy.
  • Treatment philosophy for this benign tumor entity is a completed resection of the lesion with regular follow-up MRI.
  • [MeSH-major] Brain Neoplasms / diagnostic imaging. Brain Neoplasms / surgery. Medulloblastoma / radiotherapy. Myxoma / surgery. Neoplasms, Radiation-Induced / surgery
  • [MeSH-minor] Brain / pathology. Brain / surgery. Child. Combined Modality Therapy / methods. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Radiography. Time Factors

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  • (PMID = 19946690.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 32
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88. Saxena P, Shehatha J, Naran A, Rajaratnam S, Newman MA, Konstantinov IE: Papillary fibroelastoma of the interventricular septum: mimicking a cardiac myxoma. Tex Heart Inst J; 2010;37(1):119-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary fibroelastoma of the interventricular septum: mimicking a cardiac myxoma.
  • Papillary fibroelastomas are benign cardiac tumors that involve cardiac valves.
  • These tumors are usually asymptomatic and are found incidentally during cardiac surgery or during echocardiographic evaluation in a patient who exhibits cardiac symptoms.
  • However, these tumors may cause major thromboembolic complications.

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  • (PMID = 20200644.001).
  • [ISSN] 1526-6702
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2829813
  • [Keywords] NOTNLM ; Fibroelastoma/diagnosis/pathology/surgery / heart neoplasms/pathology/surgery / treatment outcome
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89. Basoglu A, De Wolf A, Dendale P, Vanbockrijck M, Hendrikx M, Vranckx P: Echocardiography remains the standard for the diagnostic evaluation of left ventricular tumors: a case report with anatomical correlation. Eur J Echocardiogr; 2007 Oct;8(5):401-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Echocardiography remains the standard for the diagnostic evaluation of left ventricular tumors: a case report with anatomical correlation.
  • Primary cardiac tumors are rare.
  • Although the majority are benign, they may cause significant morbidity and mortality.
  • Two-dimensional transthoracic echocardiography (2D-TTE) is the primary imaging modality for the diagnosis of cardiac tumors.
  • New and more complex non-invasive imaging modalities, such as cardiac magnetic resonance (CMR), do not always provide an added value.
  • [MeSH-major] Echocardiography. Fibroma / ultrasonography. Heart Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Contrast Media. Female. Heart Ventricles. Humans. Magnetic Resonance Imaging. Phospholipids. Sulfur Hexafluoride

  • Hazardous Substances Data Bank. SULFUR HEXAFLUORIDE .
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  • (PMID = 16876483.001).
  • [ISSN] 1525-2167
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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90. Dabek J, Twardowski R, Jakubowski D, Michniak B, Swiderski R, Gasior Z: [Effectiveness of heart tumor therapy in the cardiology department during 7 year follow-up]. Pol Merkur Lekarski; 2009 Nov;27(161):362-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effectiveness of heart tumor therapy in the cardiology department during 7 year follow-up].
  • [Transliterated title] Skuteczność leczenia guzów serca rozpoznanych w klinice kardiologii w siedmioletniej obserwacji.
  • Neoplasms of the heart are rare.
  • Among primary heart neoplasms the most often benign tumors are diagnosed--mostly myxomas, whereas the majority of malignant heart tumors are sarcomas.
  • The aim of this paper was to present heart tumors diagnosed in the cardiology department, their symptoms, used diagnostic tests and therapy and to show after therapy quality of life changes.
  • MATERIAL AND METHODS: There were 18 patients included to the study, whom during hospitalization in the cardiology department heart tumors were diagnosed.
  • There were 11 women and 7 men, aged from 33- to 76-years-old (mean 60,5 years).
  • RESULTS: Among 18 heart tumor patients in 12 cases primary benign tumors were diagnosed (66,6%), 1 patient had primary malignant tumor (5,5%), there were 3 cases of metastatic tumors (16,6%) and 2 patients with non-neoplasmic tumors--clots (11,1%).
  • From 18 subjects with heart tumor 3 patients died because of advanced stage of neoplasmic disease and presence of metastatic tumors in the heart.
  • CONCLUSIONS: Results of the study show, that heart tumors, regardless of development of diagnostic tests, are still diagnosed too late.
  • The study group follow-up proved, that early diagnosis and proper heart tumor treatment prevented complications and improved the quality of life.
  • It is worth to emphasize, that coronary angiogram in some cases allowed to diagnose coronary artery disease, to treat heart tumor and to perform coronary artery by-pass grafting simultaneously.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Delayed Diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Quality of Life. Survival Rate

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  • (PMID = 19999797.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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91. Cusimano RJ: Surgical management of cardiac tumors. Semin Diagn Pathol; 2008 Feb;25(1):76-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of cardiac tumors.
  • Cardiac tumors, though rare, can affect all parts of the heart, from venous structures to atria to ventricles, valves, and great vessels.
  • Although most are benign and have good long-term prognosis, surgery for malignant tumors, whether primary or secondary, usually carries poor long-term survival.
  • Resection of ventricular tumors is limited by lack of a good ventricular muscular replacement.
  • Although cardiac transplantation has been used for tumors, long-term survival for anything but benign tumors is limited, making transplant a poor solution for any malignant tumors.
  • Outcome of resection of heart or great vessel tissue for tumors arising elsewhere is related more to the primary tumor than it is to the cardiac resection and reconstruction.
  • [MeSH-major] Heart Neoplasms / surgery

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  • (PMID = 18350926.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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92. Grabysa R, Moczulska B, Artemiuk A, Olszewski R, Kubik L: [Thrombus or tumour of the mitral valve--a case of 75-year-old woman with acute coronary syndrome and aortic insufficiency]. Pol Merkur Lekarski; 2009 Nov;27(161):393-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thrombus or tumour of the mitral valve--a case of 75-year-old woman with acute coronary syndrome and aortic insufficiency].
  • Papillary fibroelastomas are rare, primary, benign cardiac tumors most frequently located in the heart valves.
  • We provide a differential diagnosis and review of the literature concerning the pathologic intracardiac masses affecting cardiac valves.
  • [MeSH-major] Acute Coronary Syndrome / complications. Fibroma / diagnosis. Heart Neoplasms / diagnosis. Heart Valve Diseases / diagnosis. Mitral Valve / ultrasonography
  • [MeSH-minor] Aged. Aortic Valve Insufficiency / complications. Diagnosis, Differential. Echocardiography. Female. Humans. Thrombosis / diagnosis. Thrombosis / etiology

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  • (PMID = 19999803.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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93. Kosar F, Sincer I, Kuzucu A, Nisanoglu V, Gunen H: A case of a large intrapericardial lipoma occupying pericardial space: an unusual complication of a coronary artery bypass surgery. J Card Surg; 2007 Sep-Oct;22(5):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although cardiac lipomas are quite rare, they represent the second most common primary benign cardiac tumors.
  • [MeSH-major] Coronary Artery Bypass. Heart Neoplasms / diagnosis. Lipoma / diagnosis. Pericardium / pathology

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  • (PMID = 17803584.001).
  • [ISSN] 0886-0440
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Kovacević M, Simić O, Matana A, Lucin K, Stifter S: Pulmonary valve papillary fibroelastoma. A case report. Tumori; 2005 Jul-Aug;91(4):364-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient had no clinical or constitutional symptoms suggesting the presence of an intracardiac tumor.
  • Routine preoperative transthoracic echocardiography revealed a pulmonary valve tumor.
  • Histopathological analysis resulted in a diagnosis of papillary fibroelastoma.
  • Papillary fibroelastomas are rare and benign cardiac tumors.
  • They usually arise from the cardiac valves.
  • [MeSH-major] Fibroma. Heart Neoplasms. Pulmonary Valve
  • [MeSH-minor] Coronary Artery Bypass. Female. Humans. Incidental Findings. Middle Aged. Pulmonary Artery / surgery. Ultrasonography. Vascular Neoplasms / surgery

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  • (PMID = 16277107.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Yamauchi S, Ogasawara H, Suzuki S, Kuwabara W: Case report of a papillary fibroelastoma arising from the left ventricular outflow septum just beneath the aortic valve. J Nippon Med Sch; 2008 Aug;75(4):239-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cardiac papillary fibroelastomas are rare benign tumors with frond-like growths that typically involve the native valve tissue.
  • [MeSH-major] Aortic Valve. Fibroma / ultrasonography. Heart Neoplasms / ultrasonography
  • [MeSH-minor] Aged, 80 and over. Echocardiography. Heart Septum. Heart Ventricles. Humans. Male

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  • (PMID = 18781049.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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96. Botha J, Ihlberg L, Elhenawy A, Abbott M, Butany J, Paul N, Brister SJ: A giant cavernous hemangioma of the heart. Ann Thorac Surg; 2010 Jul;90(1):293-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A giant cavernous hemangioma of the heart.
  • Cardiac hemangiomas are exceptionally rare, vascular neoplasms of the heart, with an incidence of 1% to 2% among all detected benign heart tumors.
  • With the availability of the advanced imaging modalities of the heart, asymptomatic cardiac tumors are detected more frequently.
  • These tumors are composed either of capillaries or larger cavernous channels.
  • Herein, we report a rare case of a huge cardiac hemangioma involving both ventricles, which is not amenable to a curative surgical resection.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hemangioma, Cavernous / diagnosis

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20609803.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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97. Gaumann A, Strubel G, Bode-Lesniewska B, Schmidtmann I, Kriegsmann J, Kirkpatrick CJ: The role of tumor vascularisation in benign and malignant cardiovascular neoplasms: a comparison of cardiac myxoma and sarcomas of the pulmonary artery. Oncol Rep; 2008 Aug;20(2):309-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of tumor vascularisation in benign and malignant cardiovascular neoplasms: a comparison of cardiac myxoma and sarcomas of the pulmonary artery.
  • Neoangiogenesis is involved in the development and progression of malignant tumors.
  • Since the significance of the assessment of angiogenesis in soft tissue tumors is still a matter of debate, we investigated the vascularisation of cardiac myxomas and compared it with pulmonary artery sarcomas (PAS).
  • An immunohistochemical analysis of growth factors and their receptors, HIF-1alpha and tumor-associated macrophages (TAM) was performed.
  • VEGFR-2 expression was detected in a subset of tumor cells and in blood vessels mainly at the tumor periphery, whereas VEGFR-1 was weakly expressed in the tumors but prominent in the macrophages in cardiac myxomas.
  • In conclusion, benign and malignant cardiovascular tumors with a different pathophysiology develop a comparable vascularisation.
  • [MeSH-major] Heart Neoplasms / blood supply. Myxoma / blood supply. Neovascularization, Pathologic / pathology. Sarcoma / blood supply. Vascular Neoplasms / blood supply

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  • (PMID = 18636191.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 3.1.3.1 / Alkaline Phosphatase
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98. Kelekci S, Yazicioglu HF, Yilmaz B, Aygün M, Omeroglu RE: Cardiac rhabdomyoma with tuberous sclerosis: a case report. J Reprod Med; 2005 Jul;50(7):550-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac rhabdomyoma with tuberous sclerosis: a case report.
  • BACKGROUND: Rhabdomyomas are the most common benign cardiac neoplasms occurring in the fetus and neonate, with most of them identified within the first year of life.
  • Cardiac rhabdomyomas are frequently associated with tuberous sclerorosis.
  • CASE: A 25-year-old, pregnant woman with no remarkable personal or family history was referred to us for a suspected fetal cardiac anomaly.
  • Postnatal echocardiography confirmed the presence of cardiac rhabdomyoma, and periventricular subependymal multiple hamartomas were diagnosed by postnatal magnetic resonance imaging.
  • CONCLUSION: When fetal cardiac rhabdomyoma is diagnosed, careful evaluation of other fetal structures, including brain and renal parenchyma, should be performed to search for signs of tuberous sclerosis.
  • [MeSH-major] Fetal Diseases / ultrasonography. Heart Neoplasms / ultrasonography. Rhabdomyoma / ultrasonography. Tuberous Sclerosis / ultrasonography
  • [MeSH-minor] Adult. Female. Hamartoma / diagnosis. Hamartoma / embryology. Heart Septum. Heart Ventricles. Humans. Infant, Newborn. Magnetic Resonance Imaging. Pregnancy. Pregnancy Outcome. Ultrasonography, Prenatal


99. Farinelli A, Ferrara E, Cirillo M, Zorzi F: [Right ventricular cavernous hemangioma: a rare cardiac primary neoplasia]. Ital Heart J Suppl; 2005 Aug;6(8):498-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Right ventricular cavernous hemangioma: a rare cardiac primary neoplasia].
  • [Transliterated title] Grosso emangioma cavernoso del ventricolo destro: una neoplasia primitiva cardiaca molto rara.
  • Primary neoplasia of the heart is rare and often diagnosed postmortem (with a prevalence < 0.2% at postmortem examinations) due to the lack of specific clinical symptoms and signs.
  • Among benign cardiac tumors, cavernous hemangioma has a prevalence of 2.8%.
  • Less invasive diagnostic techniques such as transthoracic echocardiography allow for the diagnosis to be made during life with definitive surgical treatment.
  • Surgical treatment was indicated for symptom severity and for the unpredictable behavior of the large neoplasm.
  • [MeSH-major] Heart Neoplasms. Hemangioma, Cavernous
  • [MeSH-minor] Aged. Diagnosis, Differential. Echocardiography. Female. Follow-Up Studies. Heart Ventricles. Humans. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Ventricular Dysfunction, Right / diagnosis

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  • (PMID = 16161504.001).
  • [ISSN] 1129-4728
  • [Journal-full-title] Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology
  • [ISO-abbreviation] Ital Heart J Suppl
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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100. Arnaiz G P, Toledo G I, Borzutzky S A, Urcelay M G, Heusser R F, Garay G F, Castillo N E, Toro R L, Becker R P, Arretz V C, Córdova A S: [Cardiac tumors in children and adults: A Multicentric retrospective study]. Rev Med Chil; 2006 Sep;134(9):1135-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac tumors in children and adults: A Multicentric retrospective study].
  • [Transliterated title] Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes.
  • BACKGROUND: Cardiac tumors are very uncommon at all ages.
  • There are important clinical differences between children and adults in the behavior of these tumors.
  • AIM: To compare the behavior of primary and secondary cardiac tumors, from fetal age to adults.
  • PATIENTS AND METHOD: Multicentric retrospective analysis of 38 children and adults with cardiac tumors, evaluated with echocardiography between January 1995 and August 2001.
  • RESULTS: Tumors were diagnosed in 38 patients (13 children and 25 adults), from a total of 31.800 echocardiograms.
  • In children the diagnosis was made by fetal, transthoracic or transesophageal echocardiography in 23.6% and 8% of cases, respectively.
  • Eighty five percent were primary (10 benign and 1 malignant) and 15%, secondary tumors.
  • In adults, 76% of tumors were diagnosed by transthoracic and 20% by transesophageal echocardiography.
  • Seventy six percent were primary (18 benign and 1 malignant) and 24% secondary tumors.
  • In adults, myxomas are the predominant cardiac tumors.
  • Primary and metastasic malignant tumors are observed both in children and in adults.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Rhabdomyoma / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Chile / epidemiology. Echocardiography. Female. Fetal Heart / ultrasonography. Fibroma / epidemiology. Fibroma / ultrasonography. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Middle Aged. Myxoma / epidemiology. Myxoma / ultrasonography. Pregnancy. Retrospective Studies. Ultrasonography, Prenatal

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  • (PMID = 17171215.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Chile
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