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Items 1 to 33 of about 33
1. Arai A, Sasayama T, Tamaki M, Sakagami Y, Enoki E, Ohbayashi C, Kohmura E: Rosette-forming glioneuronal tumor of the fourth ventricle--case report. Neurol Med Chir (Tokyo); 2010;50(3):224-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette-forming glioneuronal tumor of the fourth ventricle--case report.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare tumor included as a novel glioneuronal neoplasm in the 2007 World Health Organization classification of brain tumors.
  • The tumor was gross totally resected.
  • The prognosis is benign, but relatively aggressive behaviors such as tumor growth, recurrence, and acute deterioration due to intratumoral hemorrhaging can occur.
  • Surgical resection requires care to prevent major surgical morbidities associated with lesions invading the cerebellum or brainstem.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Infratentorial Neoplasms / pathology. Neoplasms, Neuroepithelial / pathology. Teratoma / pathology

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  • (PMID = 20339273.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Stüer C, Vilz B, Majores M, Becker A, Schramm J, Simon M: Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer; 2007 Dec 15;110(12):2799-808
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  • BACKGROUND: Most pilocytic astrocytomas (piloA) are benign growths (World Health Organization [WHO] grade 1) of the deep midline structures, the brainstem, and the cerebellum.
  • RESULTS: There were 20 patients (45%) with supratentorial lobar piloA (including 10 temporal/temporomesial tumors, 5 parietal tumors, 3 insular tumors, 1 frontal tumor, and 1 occipital tumors), 12 patients with cerebellar piloA, 7 patients with brainstem piloA, 2 patients with opticochiasmatic PiloA, 1 patient with intramedullary piloA, and 2 patients with piloA of the basal ganglia.
  • All but 1 patient with a lobar tumor presented with epilepsy.
  • Tumor recurrence or disease progression was observed in 13 of 44 patients (30%).
  • CONCLUSIONS: PiloA in adult patients, surprisingly, often was not a benign disease.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Brain Neoplasms / pathology

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  • [CommentIn] Nat Clin Pract Neurol. 2008 Jun;4(6):296-7 [18414467.001]
  • (PMID = 17973253.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Broekman ML, Risselada R, Engelen-Lee J, Spliet WG, Verweij BH: Glioblastoma multiforme in the posterior cranial fossa in a patient with neurofibromatosis type I. Case Rep Med; 2009;2009:757898

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  • Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms.
  • The most common brain tumors, found in 15%-20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas.
  • These tumors generally have a benign nature.
  • NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain.

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  • (PMID = 20029672.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2796235
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4. Mpairamidis E, Alexiou GA, Stefanaki K, Sfakianos G, Prodromou N: Brainstem ganglioglioma. J Child Neurol; 2008 Dec;23(12):1481-3
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  • [Title] Brainstem ganglioglioma.
  • Gangliogliomas are usually benign slow-growing neoplasms, seen mainly in the first 3 decades of life and are prevalently located supratentorial, mostly in the temporal and frontal lobe.
  • The authors present a rare case of a brainstem ganglioglioma in an 11-year-old boy who was referred to their hospital complaining of episodes of blurry vision, loss of memory, gait disturbances, and morning headache with vomiting, lasting for over a month.
  • Computed tomography and magnetic resonance imaging scans revealed a mass on the dorsal surface of the brainstem, compressing the brainstem and producing secondary obstructive hydrocephalus.
  • A total resection should be always attempted, where possible in brainstem gangliogliomas.
  • Close follow-up is mandatory, and re-resection or radiotherapy should be considered in case of tumor recurrence.
  • [MeSH-major] Brain Stem Neoplasms. Ganglioglioma

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  • (PMID = 19073857.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Nakaya K, Niranjan A, Kondziolka D, Kano H, Khan AA, Nettel B, Koebbe C, Pirris S, Flickinger JC, Lunsford LD: Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):988-95
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  • [Title] Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression.
  • PURPOSE: This study evaluated the role of radiosurgery in the management of symptomatic patients with brainstem compression from benign basal tumors.
  • METHODS AND MATERIALS: Over a 17-year, period 246 patients (202 vestibular schwannomas and 44 meningiomas) with brainstem compression from benign skull-base tumors were managed with Gamma Knife radiosurgery.
  • Median tumor volumes were 3.9 cm(3) (range, 0.8-39.0 mL) and 6.6 mL (range, 1.6-25.1 mL) for vestibular schwannomas and meningiomas, respectively.
  • For both tumors, a median marginal dose of 13 Gy was prescribed.
  • Patients were categorized into four groups on the basis of the tumor-brainstem relationship on neuroimaging.
  • RESULTS: Preservation of function was stratified according to grade of brainstem compression.
  • We analyzed the effect of radiosurgery on symptoms of brainstem compression.
  • The tumor control rate was 100 % for meningioma and 97% for vestibular schwannomas (although 5% required an additional procedure such as a ventriculoperitoneal shunt).
  • Balance improved significantly in patients who had less tumor compression (p = 0.0357) after radiosurgery.
  • CONCLUSION: Radiosurgery is a minimally invasive option for patients with benign basal tumors that indent or distort the brainstem.
  • A high tumor growth control rate and satisfactory rate of neurological preservation and symptom control can be obtained with radiosurgery.
  • [MeSH-major] Brain Stem. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Skull Base Neoplasms / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20381265.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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6. Shah NC, Ray A, Bartels U, Rutka J, Bouffet E, Drake J, Hawkins CE, Huang A: Diffuse intrinsic brainstem tumors in neonates. Report of two cases. J Neurosurg Pediatr; 2008 May;1(5):382-5
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  • [Title] Diffuse intrinsic brainstem tumors in neonates. Report of two cases.
  • The authors report on 2 newborn infants with the unusual presentation of intrinsic brainstem tumors.
  • Diagnoses of diffuse intrinsic brainstem gliomas were made on the basis of magnetic resonance imaging, which showed large expansive, nonenhancing intrinsic pontine masses.
  • Intrinsic pontine tumors, characteristically seen in school-age children, are most often high-grade gliomas that are almost invariably fatal.
  • However, the microanatomy and natural history of pontine tumors in neonates are unknown.
  • In one child, postmortem examination revealed a primary brainstem primitive neuroectodermal tumor.
  • The authors conclude that, as in older children, neonatal intrinsic brainstem tumors may be of a highly malignant nature.
  • The rapid tumor progression in both cases indicates that where a diagnostic procedure may pose significant risks, supportive observation can aid in distinguishing malignant from benign tumor growth.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / therapy. Glioma / pathology. Glioma / therapy

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  • [CommentIn] J Neurosurg Pediatr. 2008 May;1(5):381; discussion 381 [18447672.001]
  • (PMID = 18447673.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Stark AM, Maslehaty H, Hugo HH, Mahvash M, Mehdorn HM: Glioblastoma of the cerebellum and brainstem. J Clin Neurosci; 2010 Oct;17(10):1248-51
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  • [Title] Glioblastoma of the cerebellum and brainstem.
  • Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor.
  • Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Stem / pathology. Cerebellum / pathology. Glioblastoma / pathology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20619657.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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8. Elia AE, Shih HA, Loeffler JS: Stereotactic radiation treatment for benign meningiomas. Neurosurg Focus; 2007;23(4):E5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiation treatment for benign meningiomas.
  • Meningiomas are the second most common primary tumor of the brain.
  • For incompletely resected or inoperable benign meningiomas, 3D conformal external-beam radiation therapy can provide durable local tumor control in 90 to 95% of cases.
  • Stereotactic radiotherapy is useful for larger meningiomas (> 3-3.5 cm) and those closely approximating critical structures, such as the optic chiasm and brainstem.
  • Although SRS has longer follow-up than SRT, both techniques have excellent 5-year tumor control rates of greater than 90% for benign meningiomas.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Radiosurgery

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  • (PMID = 17961042.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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9. Bhatnagar AK, Gerszten PC, Ozhasaglu C, Vogel WJ, Kalnicki S, Welch WC, Burton SA: CyberKnife Frameless Radiosurgery for the treatment of extracranial benign tumors. Technol Cancer Res Treat; 2005 Oct;4(5):571-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CyberKnife Frameless Radiosurgery for the treatment of extracranial benign tumors.
  • Limited data exists for the use of radiosurgery for benign extracranial tumors.
  • The purpose of this study was to evaluate the feasibility, toxicity, and local control of patients with benign extracranial lesions treated with the CyberKnife Frameless Radiosurgery System.
  • From September 2001 thru January 2004, 59 benign tumors in 44 patients were treated using the CyberKnife a frameless image-guided radiosurgery system.
  • Of these tumors, there were 21 neurofibromas, ten schwannomas, eight meningiomas, eight hemangioblastomas, seven paragangliomas, two hemangiopericytomas, one pseudotumor, one ependymoma, and one arteriovenous malformation (AVM).
  • The anatomic locations of these tumors were spinal (25 cervical, four thoracic, 14 lumbar, and two sacral), neck (eight), orbital (three), brainstem (one), and foramen magnum (one).
  • The median tumor dose delivered was 16.0 Gy to the 80% isodose line (range 10-31 Gy).
  • The median tumor volume was 4.3 cc (range 0.14-98.6 cc).
  • This study suggests that CyberKnife Radiosurgery is a safe and efficacious treatment modality for benign tumors, even for those patients with recurrent previously irradiated lesions.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasms / surgery. Radiosurgery / methods
  • [MeSH-minor] Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Meningeal Neoplasms / surgery. Meningioma / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Safety. Spinal Cord Neoplasms / surgery

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  • (PMID = 16173828.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Cozzi L, Clivio A, Vanetti E, Nicolini G, Fogliata A: Comparative planning study for proton radiotherapy of benign brain tumors. Strahlenther Onkol; 2006 Jul;182(7):376-81
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  • [Title] Comparative planning study for proton radiotherapy of benign brain tumors.
  • Twelve cases of "benign" brain tumors were considered (meningiomas, neurinomas, and hypophyseal adenomas).
  • Organs at risk included chiasm, brainstem, eyes and optic nerves as well as the not otherwise specified healthy brain tissue in view of long-term toxicity.
  • Plans designed with the spot-scanning technique presented the minimum involvement of healthy tissue (e. g., the lowest maximum significant dose to healthy brain [25.6 Gy] or the lowest conformity index [CI(95) = 1.3], between 38% and 46% lower than for the other techniques).
  • [MeSH-major] Brain Neoplasms / radiotherapy. Protons / therapeutic use. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Computer-Assisted / methods

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  • (PMID = 16826355.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Protons
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11. Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BW, Neff BA, Link MJ: Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2. J Neurosurg; 2010 Jan;112(1):81-7
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  • [Title] Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2.
  • Neurofibromatosis Type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of benign tumors of the peripheral nervous system and the CNS, including schwannomas, meningiomas, and ependymomas.
  • The gene responsible for the development of NF2 acts as a tumor suppressor gene.
  • Stereotactic radiotherapy (SRT) or single-fraction stereotactic radiosurgery has been increasingly used in the past decades to treat benign tumors in patients with NF2.
  • These radiotherapy methods are less invasive and can be potentially used to treat multiple tumors in a single session.
  • Few reports exist of malignant peripheral nerve sheath tumors, meningiomas, or ependymomas occurring after SRT or stereotactic radiosurgery in patients with NF2.
  • Compared with patients with sporadic tumors, NF2 patients having a germline tumor suppressor gene defect may be more prone to secondary malignancies after treatment involving radiation therapy.
  • [MeSH-major] Brain Stem Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Neurofibromatosis 2 / surgery. Radiosurgery / adverse effects. Rhabdomyosarcoma / etiology
  • [MeSH-minor] Adult. Brain Neoplasms / etiology. Brain Neoplasms / surgery. Brain Stem / pathology. Brain Stem / radiation effects. Brain Stem / surgery. Ear Neoplasms / etiology. Ear Neoplasms / surgery. Fatal Outcome. Female. Humans. Neurilemmoma / etiology. Neurilemmoma / surgery. Vestibular Diseases / etiology. Vestibular Diseases / surgery

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  • [ErratumIn] J Neurosurg. 2010 Jan;112(1):209. Scheithauer, Bernd B [corrected to Scheithauer, Bernd W]
  • (PMID = 19575577.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ondik MP, Preston T, Towfighi J, Isaacson JE: Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor. Otol Neurotol; 2007 Dec;28(8):1091-3
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  • [Title] Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor.
  • OBJECTIVE: A benign epithelioid peripheral nerve sheath tumor is described in the setting of congenital facial nerve (FN) paralysis.
  • INTERVENTIONS: Auditory brainstem evoked potential study, gadolinium-enhanced magnetic resonance imaging, temporal bone computed tomography, and transmastoid FN decompression with tumor resection.
  • MAIN OUTCOME MEASURES: Follow-up for tumor recurrence and postoperative FN function.
  • RESULTS: The child underwent a transmastoid FN exploration with resection of a 0.6-cm spherical tumor analyzed to be a benign epithelioid peripheral nerve sheath tumor.
  • CONCLUSION: Benign epithelioid peripheral nerve sheath tumor can cause congenital facial nerve palsy.
  • [MeSH-major] Facial Nerve Diseases / congenital. Facial Nerve Diseases / etiology. Neoplasms, Glandular and Epithelial / complications. Neoplasms, Glandular and Epithelial / congenital. Nerve Sheath Neoplasms / complications. Nerve Sheath Neoplasms / congenital
  • [MeSH-minor] Decompression, Surgical. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve / physiology. Facial Paralysis / congenital. Facial Paralysis / etiology. Female. Gadolinium. Humans. Infant. Magnetic Resonance Imaging. Temporal Bone / radiography

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  • (PMID = 18084823.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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13. Farr MR, Martin TP, Walsh AR, Irving RM: A case of paraganglioma of the hypoglossal nerve. J Laryngol Otol; 2010 May;124(5):e3

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  • Our patient presented as an emergency with long tract neurological symptoms and progressive brainstem involvement.
  • This presentation is not characteristic of paragangliomas in general, which usually have an indolent growth pattern and often demonstrate benign symptoms for a number of years prior to diagnosis.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Hypoglossal Nerve Diseases / diagnosis. Paraganglioma / diagnosis

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  • (PMID = 20403225.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Wu Z, Zhang J, Zhang L, Jia G, Tang J, Wang L, Wang Z: Prognostic factors for long-term outcome of patients with surgical resection of skull base chordomas-106 cases review in one institution. Neurosurg Rev; 2010 Oct;33(4):451-6

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  • The previous radiotherapy or surgery, dedifferentiated pathology, and less tumor resection are risk factors for longterm survival and recurrence (p < 0.05).
  • Although there is no statistic significant role of tumor adherent to vital structure for outcome (p = 0.051), it can not exclude its importance for favorable outcome.
  • Gender, age, tumor size and staging are not independent risk factors for outcome.
  • Surgical technique leading to radical tumor resection with less morbidity is advocatory and beneficial for patients with skull base chordoma with long term outcome, if the tumor could be exposed and resected completely, the recurrence rate was very low for most benign chordomas.
  • [MeSH-major] Chordoma / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Regression Analysis. Retrospective Studies. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 20668904.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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15. Cho JM, Ahn JY, Kim SH, Lee KS, Chang JH: An endodermal cyst mimicking an intra-axial tumor in the medulla oblongata. Childs Nerv Syst; 2010 Jun;26(6):853-6
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  • [Title] An endodermal cyst mimicking an intra-axial tumor in the medulla oblongata.
  • INTRODUCTION: Endodermal cysts, also known as enterogenous, neurenteric, foregut, epithelial, bronchogenic, or respiratory cysts, are rare benign lesions lined by columnar epithelium of a presumed endodermal origin.
  • Endodermal cysts are rarely intracranial, but when this occurs, the cysts are frequently located in the posterior fossa with the most common locations being anterior to the brainstem and within the fourth ventricle.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Neoplasms / diagnosis. Cysts / diagnosis. Medulla Oblongata

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  • [CommentIn] Childs Nerv Syst. 2011 Jun;27(6):861-2; author reply 863 [21503756.001]
  • (PMID = 20217097.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Barajas RF Jr, Chi J, Guo L, Barbaro N: Microvascular decompression in hemifacial spasm resulting from a cerebellopontine angle lipoma: case report. Neurosurgery; 2008 Oct;63(4):E815-6; discussion E816
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  • No attempt was made to resect the lipoma, given the risk to injury of the brainstem and perforating blood vessels.
  • CONCLUSION: This case demonstrates that relief of the vascular compression, when present, of the VIIth cranial nerve is sufficient for resolution of hemifacial spasm symptoms, even when associated with nearby, benign lesions.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Decompression, Surgical / methods. Hemifacial Spasm / etiology. Lipoma / complications. Vascular Surgical Procedures / methods
  • [MeSH-minor] Aged. Cerebral Arteries / pathology. Cerebral Arteries / surgery. Electromyography. Evoked Potentials, Auditory, Brain Stem. Facial Nerve / pathology. Facial Nerve / surgery. Hearing Loss / diagnosis. Hearing Loss / etiology. Humans. Male. Monitoring, Intraoperative. Neurosurgical Procedures / methods. Polytetrafluoroethylene. Prostheses and Implants. Recovery of Function. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve / surgery

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  • (PMID = 18981850.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / TL1 RR024129-01
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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17. Vougioukas VI, Gläsker S, Hubbe U, Berlis A, Omran H, Neumann HP, Van Velthoven V: Surgical treatment of hemangioblastomas of the central nervous system in pediatric patients. Childs Nerv Syst; 2006 Sep;22(9):1149-53
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  • OBJECTIVE: Hemangioblastomas are histologically benign lesions that occur sporadically or as a manifestation of von Hippel-Lindau disease (VHL).
  • The treatment strategy of these neoplasms is complicated by their unpredictable growth patterns and the often irreversible neurological deficits they may cause.
  • Ten patients were affected by von Hippel-Lindau and three were with sporadic tumors.
  • Two patients with brainstem tumors exhibited transient hemiparesis and caudal nerve palsy, respectively.
  • Preoperatively symptomatic patients with spinal tumors did not deteriorate nor improve after surgery.
  • During the observed follow-up periods, no tumor recurrences were observed.
  • Molecular screening of every pediatric patient and family is mandatory to enable the detection of extraneurological tumors and the development of an efficient therapeutic strategy.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / surgery
  • [MeSH-minor] Adolescent. Brain Stem / pathology. Brain Stem / surgery. Cerebellum / pathology. Cerebellum / surgery. Child. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Postoperative Complications / diagnosis. Spinal Cord / pathology. Spinal Cord / surgery

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  • (PMID = 16369852.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Chennupati SK, Schipor I, Mirza N: Microdebrider decompression of schwannoma: a novel method of excising a neck mass. Laryngoscope; 2006 Nov;116(11):2086-8
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  • Given her auditory brainstem implant, unipolar cautery was contraindicated.
  • This method may be applied to other large benign masses in the neck as well.
  • [MeSH-major] Debridement. Decompression, Surgical. Head and Neck Neoplasms / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 17075428.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Albers AC, Gutmann DH: Gliomas in patients with neurofibromatosis type 1. Expert Rev Neurother; 2009 Apr;9(4):535-9
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  • Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disorder characterized by numerous cutaneous features, including café-au-lait macules, skinfold freckling and iris hamartomas.
  • In addition, individuals with NF1 are prone to the development of both benign and malignant tumors.
  • The most common CNS tumor in children and adults with NF1 is the glioma.
  • In childhood, gliomas are primarily located in the optic pathway, and less frequently in the hypothalamus and brainstem.
  • Regular ophthalmologic evaluations in children are essential for the effective management of these tumors in patients with NF1.
  • [MeSH-major] Brain Neoplasms / complications. Glioma / complications. Neurofibromatosis 1 / complications


20. Hattingen E, Blasel S, Nichtweiss M, Zanella FE, Weidauer S: MR imaging of midbrain pathologies. Clin Neuroradiol; 2010 Jun;20(2):81-97
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  • The spectrum of pathologic processes affecting the midbrain features some differences to other brain areas.
  • Primary midbrain tumors are also infrequent and often show a benign clinical course.
  • Apart from multiple sclerosis other inflammatory autoimmune processes and some infectious agents predominantly affect the brainstem including the midbrain.
  • [MeSH-major] Brain Stem Hemorrhage, Traumatic / diagnosis. Brain Stem Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Mesencephalon / pathology

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  • (PMID = 20532857.001).
  • [ISSN] 1869-1447
  • [Journal-full-title] Clinical neuroradiology
  • [ISO-abbreviation] Clin Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 103
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21. Hargrave D: Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy. Br J Neurosurg; 2009 Aug;23(4):351-63
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  • Gliomas are the most common type of paediatric brain tumour and range from benign low grade gliomas which can be resected/observed to aggressive brainstem gliomas with dismal survival rates.
  • Pilocytic astrocytoma, the most common childhood low grade brain tumour, has recently been shown to harbour an activated BRAF/MAPK/ERK pathway in the majority of cases; this represents an attractive target for new agents.
  • Brainstem glioma remains a tumour with a dismal prognosis but relatively little is known about the underlying biology and progress will require a concerted effort to collect tissue by biopsy and autopsy to allow appropriate analysis to identify and validate targets.
  • [MeSH-major] Brain Neoplasms. Glioma / pathology
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / genetics. Astrocytoma / pathology. Astrocytoma / therapy. Child. Child, Preschool. Combined Modality Therapy. Drug Delivery Systems. Genetic Predisposition to Disease. Genome-Wide Association Study. Hamartoma Syndrome, Multiple / genetics. Humans. Infant. Neoplasm Staging. Neurofibromatosis 1 / genetics. Prognosis. Tuberous Sclerosis / genetics

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  • (PMID = 19637006.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 170
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22. Zhao YC, Li NY, Zhou XJ, Zhou HB, Ma HH, Zhang RS: [Clinicopathologic study of pilocytic astrocytoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Sep;37(9):609-14
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  • Cystic degeneration was noted in 41 cases (60.3%), and enhancement of the tumor was noted in 43 cases (87.8%).
  • Total tumor excision was performed in 35 patients, subtotal tumor excision was performed in 31 patients, and the procedures of other 2 patients were not clear.
  • Among 51 patients with follow-up information, 44 were alive, 7 had recurrent tumor, and 7 died.
  • Tumors with classic histopathology demonstrated biphasic pattern of growth, consisting of compact elongated bipolar astrocytes associated with rosenthal fibers, and less cellular areas of multipolar cells with granular bodies and microcyst.
  • All cases showed diffuse positive staining for GFAP and low expression for Ki-67, except 1 anaplastic tumor with 10% Ki-67 indices.
  • Tumors with subarachnoid space involvement showed positive reticular fiber staining and negative EMA staining.
  • CONCLUSIONS: PA is a benign, WHO grade I tumor with favorable prognosis, and does not require radiotherapy after total resection.
  • The tumor can be mistaken as higher-grade astrocytoma when involving the subarachnoid space, and with cytological atypia, leading to unnecessary radiotherapy after surgery.
  • The outcome for patients with brainstem tumor or anaplastic PA is poor.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Glial Fibrillary Acidic Protein / genetics. Recurrence

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  • (PMID = 19094585.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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23. Gessi M, Legnani FG, Maderna E, Casali C, Solero CL, Pollo B, DiMeco F: Mucinous low-grade adenocarcinoma arising in an intracranial enterogenous cyst: case report. Neurosurgery; 2008 Apr;62(4):E972-3; discussion E973
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  • They are usually benign lesions, and malignant transformation is rare.
  • The cyst was adherent to the brainstem, cranial nerves, and vessels, and it resembled a thin encapsulated structure filled with mucinous-like substance.
  • Magnetic resonance imaging was performed 5 months postoperatively due to progressive clinical worsening; this scan revealed lesion recurrence with severe brainstem compression.
  • Subsequent follow-up computed tomographic scans showed progression of the residual tumor.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Cysts / diagnosis. Cysts / surgery. Ventriculoperitoneal Shunt

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  • (PMID = 18496166.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Ito E, Saito K, Nagatani T, Ishiyama J, Terada K, Yoshida M, Wakabayashi T: Intradural cranial chordoma. World Neurosurg; 2010 Mar;73(3):194-7; discussion e31
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  • BACKGROUND: Intradural chordomas are rare and have been considered benign owing to the feasibility of complete resection and the display of lesser aggressive biologic behavior than typical chordomas.
  • A tumor (anti-Ki-67 monoclonal antibody [MIB-1], 13.9%) in a 59-year-old woman was strongly adherent to the brainstem and involved the basilar artery and its branches.
  • After subtotal removal, the remnant tumor was treated with stereotactic radiotherapy.
  • A tumor (MIB-1, 6.2%) in a 75-year-old woman repeatedly recurred even after initial gross total removal.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Chordoma / diagnosis. Chordoma / therapy. Dura Mater

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20860957.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Franco-Vidal V, Négrevergne M, Darrouzet V: [Vertigo and pathology of the cerebello-pontine angle]. Rev Laryngol Otol Rhinol (Bord); 2005;126(4):223-6
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  • Usually they are due to benign or malignant tumors.
  • Finally very big tumors can be compressive on the cerebellum or on the brainstem inducing also dizziness.
  • Vertigo is often an important symptom of cerebello-pontine angle tumors.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Vertigo / etiology

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  • (PMID = 16496548.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 16
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26. Warren FM, Shelton C, Wiggins RH 3rd, Herrod HC, Harnsberger HR: Imaging characteristics of metastatic lesions to the cerebellopontine angle. Otol Neurotol; 2008 Sep;29(6):835-8
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  • T1 magnetic resonance imaging was most commonly isointense to hypointense to brain, with enhancement on T1 imaging with contrast.
  • T2 and fluid-attenuated inversion-recovery (FLAIR) imaging shows adjacent cerebellar and brainstem vasogenic edema.
  • Characteristics that differentiate metastatic lesions from benign lesions of the CPA include vasogenic edema on T2 and FLAIR imaging and multiple central nervous system lesions and lesions that are eccentric to the IAC.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Cerebellopontine Angle. Ear, Inner
  • [MeSH-minor] Breast Neoplasms / epidemiology. Breast Neoplasms / pathology. Colonic Neoplasms / epidemiology. Colonic Neoplasms / pathology. Female. Humans. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology. Lung Neoplasms / epidemiology. Lung Neoplasms / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 18636029.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Zhou LF, Mao Y, Zhang R: Surgical treatment of dumbbell-shaped neurinomas: report of an experience with 57 cases in a single hospital. Surg Neurol; 2007 Dec;68(6):594-602
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  • BACKGROUND: Dumbbell-shaped trigeminal neurinomas are rare benign tumors with a controversy regarding their treatment and surgical approaches.
  • METHODS: One hundred thirty-seven patients with trigeminal neurinomas, accounting for 0.6% of all intracranial tumors and 3.8% of intracranial neurinomas, were screened out from the data bank on brain tumors in Hua Shan Hospital (Shanghai, China) from 1978 to 2003.
  • After the tumor in the middle cranial fossa was resected, the tumor in the posterior fossa was resected via a suboccipital approach in the early group and through enlarged porus trigeminus without resection of the petrous apex in the latter group.
  • RESULTS: There were 12 patients in the early group and 45 patients (including 6 patients with recurrent tumors) in the latter group.
  • Tumor size measured on MRI and/or CT were 30 to 40 mm in 4 (33%) cases from the early group and 14 (31%) cases from the latter group, 41 to 50 mm in 8 (67%) cases from the early group and 25 (56%) cases from the latter group, and more than 50 mm in 6 (13%) cases from the latter group.
  • There were 3 patients in the latter group with a tumor extending into the infratemporal fossa and pterygopalatine fossa.
  • Total tumor resection was achieved in 42% (5/12) of the early group and 87% (39/45) of the latter group (chi(2) = 10.897, P < .001); incomplete tumor removal was done in 58% (7/12) of the early group and 13% (6/45) of the latter group.
  • One patient in the early group died of brainstem injury postoperatively.
  • Recurrent tumors occurred in 3 patients from the early group and were reoperated on.
  • One patient with a recurrent tumor from the latter group underwent radiosurgery 5 years after the operation.
  • It is not necessary to resect the petrous apex for removal of the tumor in the posterior fossa.
  • Radiosurgery can be used for the residual or recurrent tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery. Trigeminal Nerve / surgery

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  • (PMID = 18053854.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Houtteville JP: [Cavernomas of the central nervous system. Historical data and changing ideas]. Neurochirurgie; 2007 Jun;53(2-3 Pt 2):117-21
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  • 2) hemodynamically, the annual risk of hemorrhage increases after a first bleeding and in deep located lesions (brainstem);.
  • 4) immunocytochemical studies (PCNA) show that cavernomas should be considered more as a benign vascular tumor than as a malformation;.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Hemangioma, Cavernous, Central Nervous System / pathology

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  • (PMID = 17499816.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 14
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29. Bikmaz K, Guerrero CA, Dammers R, Krisht AF, Husain MM: Ectopic recurrence of craniopharyngiomas: case report. Neurosurgery; 2009 Feb;64(2):E382-3; discussion E383
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  • OBJECTIVE: Craniopharyngiomas are benign tumors that originate from squamous cell rests of the embryonal hypophyseal-pharyngeal duct located along the pituitary stalk.
  • After their surgical resection, recurrence usually occurs in the region of the original tumor bed.
  • Her magnetic resonance imaging scan revealed a tumor in the prepontine cistern.
  • INTERVENTION: The first patient underwent operation via a petrosal approach with subtotal resection of the tumor and decompression of the brainstem; this patient had an uneventful postoperative course.
  • The tumor in the second patient was surgically resected through a pterional craniotomy, with an uneventful postoperative course.
  • The third patient's right-sided cerebellopontine angle lesion was microsurgically resected, and the patient was given a single-dose gamma knife for the left-side and residual small right-side tumor.
  • CONCLUSION: Although ectopic recurrence of a craniopharyngioma is very rare, it should always be considered in the differential diagnosis of what appears to be a new tumor in a patient with a history of previously resected craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery

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  • (PMID = 19190442.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. de Ipolyi AR, Yang I, Buckley A, Barbaro NM, Cheung SW, Parsa AT: Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report. Neurosurgery; 2008 May;62(5):E1164-5; discussion E1165
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  • OBJECTIVE: A vestibular schwannoma (VS) is a benign tumor of the VIIIth cranial nerve that can often be treated by microsurgery or radiosurgery and demonstrates high tumor control rates.
  • INTERVENTION: After GKS with a 12-Gy dose to the 50% isodose line, the tumor expanded transiently to 3.2 cm and then regressed to 1.0 cm over the next 2 years.
  • Magnetic resonance imaging revealed a 3.2-cm multicystic VS that compressed the brainstem.
  • After microsurgical tumor excision, the patient's symptoms abated.
  • The mechanisms responsible for radiation-induced cystic tumor expansion have not been thoroughly elucidated.
  • The risk of unpredictable tumor enlargement should be discussed with patients when considering GKS for cystic tumors.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Aged. Breast Neoplasms / pathology. Cysts / pathology. Cysts / surgery. Female. Hearing Loss / etiology. Humans. Hyperthyroidism / pathology. Magnetic Resonance Imaging. Microsurgery. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery

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  • (PMID = 18580785.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Burn S, Gunny R, Phipps K, Gaze M, Hayward R: Incidence of cavernoma development in children after radiotherapy for brain tumors. J Neurosurg; 2007 May;106(5 Suppl):379-83
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  • [Title] Incidence of cavernoma development in children after radiotherapy for brain tumors.
  • OBJECT: Cavernous hemangiomas (cavernomas) are benign vascular malformations that may cause seizures and/or hemorrhage when they develop in the brain.
  • The incidence of cavernoma development after brain radiotherapy is unknown.
  • The aim of this study was to assess the prevalence of cavernoma formation in patients who had previously received radiotherapy for brain tumors during childhood.
  • METHODS: All patients were identified who were younger than 16 years of age and had undergone radiotherapy for brain tumors within a 16-year period (January 1, 1988-December 31, 2003).
  • Children who were followed up for less than 1 month after radiotherapy or who died during treatment were excluded, as were children with brainstem tumors.
  • The authors conclude that there is an increased risk of developing an intracranial cavernoma after radiotherapy for brain tumors.
  • [MeSH-major] Brain Neoplasms / etiology. Brain Neoplasms / radiotherapy. Hemangioma, Cavernous / epidemiology. Hemangioma, Cavernous / etiology. Radiation Injuries / complications

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  • (PMID = 17566205.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Kovács T, Osztie E, Bodrogi L, Pajor P, Farsang M, Juhász C, Szirmai I: Cerebellar developmental venous anomalies with associated vascular pathology. Br J Neurosurg; 2007 Apr;21(2):217-23
MedlinePlus Health Information. consumer health - Cerebellar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cerebellar developmental venous anomalies (CDVA) are benign conditions, although sometimes they are associated with haemorrhages and reported to be symptomatic.
  • One patient had two CDVAs, while another had a unique draining vein from the upper part of the brainstem too.
  • In conclusion, CDVAs are benign, asymptomatic conditions, but they are sometimes associated with pathogenic malformations requiring detailed neuroradiological investigations.
  • [MeSH-minor] Adult. Brain Stem Neoplasms / complications. Brain Stem Neoplasms / pathology. Female. Follow-Up Studies. Hemangioma, Cavernous / complications. Hemangioma, Cavernous / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 17453792.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Ladziński P, Majchrzak H, Kaspera W, Maliszewski M, Majchrzak K, Tymowski M, Adamczyk P: Direct and remote outcome after treatment of tumours involving the central skull base with the extended subfrontal approach. Neurol Neurochir Pol; 2009 Jan-Feb;43(1):22-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The approximate volume of the operated tumour, its relation to the large blood vessels, cranial nerves and brainstem, as well as consistency and vascularisation were assessed.
  • CONCLUSIONS: Extended subfrontal approach is a useful technique for removal of benign tumours expanding along the midline, superiorly and inferiorly to the skull base.
  • [MeSH-major] Neurosurgical Procedures / mortality. Skull Base Neoplasms / mortality. Skull Base Neoplasms / surgery

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  • (PMID = 19353441.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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