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1. Park YK, Kim EJ, Kim SW: Osteoblastoma of the ethmoid sinus. Skeletal Radiol; 2007 May;36(5):463-7
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  • An osteoblastoma is a benign bone tumor that most often occurs in the vertebral column and the long bones of the extremities.
  • A mixture of ground glass opacity and dense bone was present.
  • Histologically, the lesion was composed of proliferating osteoblasts along with small trabeculae of woven bone and rich vascular fibrous stroma.
  • [MeSH-major] Ethmoid Sinus / pathology. Ethmoid Sinus / surgery. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 17265159.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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2. Liang X, Jiang D, Ni W: [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):785-8
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  • [Title] [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor].
  • OBJECTIVE: To observe the clinical effect and safety of the nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite in repairing the bone defects due to benign bone tumors.
  • METHODS: From January 2003 to May 2005, 38 patients (21 males, 16 females; age, 19-58 years, averaged 38.5 years) with the bone defects due to benign bone tumors were treated with the n-HA/PA66 grains.
  • Among the 37 patients, 11 had fibrous dysplasia, 14 had bone cyst, 10 had giant cell tumor of the bone (Grade I ), and 2 had enchondroma.
  • The tumors ranged in size from 1.0 cm x 0.7 cm x 0.4 cm to 10.0 cm x 4.0 cm x 3.0 cm, with the location of the proximal femur in 12 patients, the distal femur in 7, the proximal tibia in 9, the proximal humerus in 5, the phalanges of the finger in 2, the metacarpal bone in 1, and the calcaneus in 1.
  • All the benign bone tumors underwent the curettage treatment, and then the tumor cavities were filled up with the n-HA/PA66 grains.
  • The incision healing, local inflammatory reaction, rejection, toxic reaction, tumor cavity healing, and function recovery of the limbs were all observed after operation.
  • At 3 to 5.5 months(mean 4 months) after operation, osteogenesis was found in the space filled with the n-HA/PA66 grains.
  • CONCLUSION: The n-HA/PA66 grains have great biological safety, good biocompatibility, and good bone conduction, which are good materials for the bone repair and reconstruction, and can be safely, and effectively used for repairing the bone defects due to benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes. Hydroxyapatites. Nylons
  • [MeSH-minor] Adult. Biocompatible Materials. Bone Cysts / surgery. Female. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Nanostructures. Reconstructive Surgical Procedures / methods. Treatment Outcome. Wound Healing. Young Adult

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  • (PMID = 17882867.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / Nylons
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3. Vlychou M, Athanasou NA: Radiological and pathological diagnosis of paediatric bone tumours and tumour-like lesions. Pathology; 2008 Feb;40(2):196-216
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  • [Title] Radiological and pathological diagnosis of paediatric bone tumours and tumour-like lesions.
  • Primary bone tumours are rare but account for a significant proportion of cancers occurring in childhood and adolescence.
  • Malignant bone tumours need to be distinguished not only from their benign counterparts but also from tumour-like lesions, many of which are developmental or reactive in nature and are found commonly in the paediatric population.
  • Taking note of the age of the patient and the site of the lesion within bone (aided by several imaging techniques including plain radiographs, ultrasound, computed tomography, bone scintigraphy and magnetic resonance imaging) is essential for pathological diagnosis.
  • Immunohistochemistry, cytogenetics, molecular analysis and other techniques are now powerful diagnostic tools in bone pathology.
  • This review aims to provide an approach to the radiological and pathological diagnosis of paediatric bone tumours.
  • It also provides a brief overview of some of the more common bone tumours and tumour-like lesions, both benign and malignant, which occur in childhood and adolescence.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biopsy. Bone Cysts / diagnosis. Bone Cysts / pathology. Bone Cysts / radiography. Bone Diseases, Developmental / diagnosis. Bone Diseases, Developmental / pathology. Bone Diseases, Developmental / radiography. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn

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  • (PMID = 18203042.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 142
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4. Abolghasemian M, Rezaie M, Behgoo A, Shoushtarizadeh T, Ghazavi MT: Exostosis-like intra-articular periosteal osteoblastoma: a rare case. Am J Orthop (Belle Mead NJ); 2010 Jun;39(6):E50-3
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  • Osteoblastoma is a relatively rare benign bone tumor, most often located in the vertebral column or metaphysis of the long bones, particularly the femur and the tibia.
  • Exostosis-like appearance is not common even in periosteal osteoblastoma, a very rare type of this tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Hip Joint / pathology. Osteoblastoma / pathology. Periosteum / pathology

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  • (PMID = 20631934.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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  • (PMID = 18401591.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Ech-Charif S, Aubert S, Buob D, Verhulst P, Blomme V, Migaud H, Leroy X: [Giant cell tumor of soft tissues. Report of two cases]. Ann Pathol; 2006 Feb;26(1):26-9
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  • [Title] [Giant cell tumor of soft tissues. Report of two cases].
  • [Transliterated title] Tumeur à cellules géantes des tissus mous.
  • We report two cases of giant-cell tumour of soft tissue (TCG-TM).
  • The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg.
  • Pathological study revealed a tumour comparable to benign giant cell tumour of bone.
  • The patient is well without recurrence 10 months after the diagnosis.
  • Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells.
  • TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone.
  • The differential diagnosis includes other tumours rich in osteoclast-like cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Female. Giant Cells / pathology. Humans. Leukocytes, Mononuclear / pathology. Male. Middle Aged

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  • (PMID = 16841007.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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7. Khin YT, Peh WC, Lee VK, Teo HE, Ng SB, Nathan SS: Aggressive osteoblastoma of the proximal humerus. Singapore Med J; 2009 Jan;50(1):e1-4
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  • Bone scintiscan showed solitary marked uptake.
  • The final diagnosis was osteoblastoma with aggressive features.
  • Osteoblastoma is a relatively rare benign tumour that typically occurs in the posterior elements of the vertebral column.
  • [MeSH-major] Bone Neoplasms / diagnosis. Humerus. Osteoblastoma / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, Emission-Computed

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  • (PMID = 19224061.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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8. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Ganyusufoglu AK, Ayalp K, Oztürk C, Sakallioglu U, Ozer O: Intraosseous leiomyoma in a rib. A case report. Acta Orthop Belg; 2009 Aug;75(4):561-5
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  • This rare benign tumour should be included in the differential diagnosis of any relatively small intraosseous lesion with benign imaging findings, but with gradually worsening, long-standing pain.
  • [MeSH-major] Bone Neoplasms / diagnosis. Leiomyoma / diagnosis. Ribs

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  • (PMID = 19774829.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Actins
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10. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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11. Dobashi Y, Watanabe H, Matsubara M, Yanagawa T, Raz A, Shimamiya T, Ooi A: Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours. J Pathol; 2006 Jan;208(1):44-53
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  • [Title] Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours.
  • In order to assess the involvement of autocrine motility factor (AMF) in mesenchymal tumours, AMF protein and mRNA expression was analysed in tumours, tumour-like lesions, and other lesions of bone and soft tissue.
  • Chordoid, chondroid, and muscular tumours revealed higher immunoreactivity in both benign and malignant tumours.
  • Generally, malignant tumours revealed higher expression of AMF than benign tumours of the same histopathological lineage, except for dermatofibroma/dermatofibrosarcoma protuberans.
  • In addition, higher expression of its mRNA may indicate higher levels of protein secretion and define a particularly aggressive group of tumours with high metastatic potential.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose-6-Phosphate / metabolism. Glucose-6-Phosphate Isomerase / analysis. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Immunoblotting / methods. Immunohistochemistry / methods. Neoplasm Metastasis. Neoplasm Proteins / analysis. Proteasome Inhibitors. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16294294.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-51714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proteasome Inhibitors; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 56-73-5 / Glucose-6-Phosphate; EC 5.3.1.9 / Glucose-6-Phosphate Isomerase
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12. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy


13. Dellmann A, Schroeder HG, Donhuijsen K: Destructive tumours of the larynx mimicking osteosarcoma: two cases of osteoblastoma with organ-saving resection and follow-up. Eur Arch Otorhinolaryngol; 2010 Jan;267(1):151-4
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  • [Title] Destructive tumours of the larynx mimicking osteosarcoma: two cases of osteoblastoma with organ-saving resection and follow-up.
  • Osteoblastoma of the larynx is an extremely rare type of locally progressive and destructive tumour which is mimicking osteosarcoma radiologically and histologically.
  • Since prognostic and therapeutic strategies for benign osteoblastoma differ from the more common osteosarcoma of the larynx, a meticulous pre-operative histological diagnosis is required to avoid over-therapy.
  • We report about two patients with osteoblastoma of the larynx with organ-saving resection and long-period follow-up without tumour recurrence.
  • This situation is quite different from the usual osteoblastomas of bone, which occur in young adults of both sexes equally.
  • [MeSH-major] Laryngeal Neoplasms / surgery. Laryngectomy / methods. Osteoblastoma / surgery. Osteosarcoma / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Laryngoscopy. Male. Tomography, X-Ray Computed

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  • (PMID = 19760213.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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14. Bovée JV: Multiple osteochondromas. Orphanet J Rare Dis; 2008;3:3
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  • MO is an autosomal dominant disorder and is genetically heterogeneous.
  • In almost 90% of MO patients germline mutations in the tumour suppressor genes EXT1 or EXT2 are found.
  • The diagnosis is based on radiological and clinical documentation, supplemented with, if available, histological evaluation of osteochondromas.
  • If the exact mutation is known antenatal diagnosis is technically possible.
  • Osteochondromas are benign lesions and do not affect life expectancy.
  • For secondary peripheral chondrosarcoma, en-bloc resection of the lesion and its pseudocapsule with tumour-free margins, preferably in a bone tumour referral centre, should be performed.
  • [MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic. Chondrosarcoma / pathology. Exostoses, Multiple Hereditary / diagnosis. Exostoses, Multiple Hereditary / genetics
  • [MeSH-minor] Adult. Animals. Child. Diagnosis, Differential. Female. Genetic Counseling. Humans. Male. Mutation / genetics. N-Acetylglucosaminyltransferases / genetics. Prognosis. Sex Factors

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  • (PMID = 18271966.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC2276198
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15. Prietzel T, Drummer N, von Salis-Soglio G: [Operative treatment of an expansive enchondroma of the distal phalanx of the thumb]. Orthopade; 2007 Nov;36(11):1062-5
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  • Enchondroma is the second most common benign bone tumour and the most common tumour affecting the bones of the hand.
  • By operative treatment (curettage, reduction plastic and cancellous bone allografting) we were able to correct the deformity of the distal phalanx and the thumbnail almost completely, as well as improving the stability and achieving a good cosmetic result.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Finger Phalanges / surgery
  • [MeSH-minor] Bone Transplantation. Esthetics. Follow-Up Studies. Humans. Male. Middle Aged. Nails, Malformed / diagnostic imaging. Nails, Malformed / surgery. Postoperative Complications / diagnostic imaging. Radiography

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  • (PMID = 17972061.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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17. Eyichukwu GO, Ogugua PC: Osteoclastoma in an infant. Niger J Med; 2007 Oct-Dec;16(4):378-80
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  • BACKGROUND: Conventionally, osteoclastoma is a benign but locally aggressive bone tumour with a tendency for local recurrence and rarely distant metastasis, diagnosed mainly in young adults, 15-40 years of age.
  • Diagnosis before skeletal maturity is circumspect.
  • We report a case of giant cell tumour of the clavicle (uncommon site) in a 2% year old girl that was first noticed at 6 months of age.
  • It rapidly increased in size to involve the entire clavicle with associated pain following manipulation by a traditional bone setter about 6 months after onset.
  • [MeSH-major] Clavicle / pathology. Giant Cell Tumor of Bone / pathology

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  • (PMID = 18080601.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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18. Bonekamp D, Jacene H, Bartelt D, Aygun N: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med; 2008 Dec;33(12):909-11
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  • Fibrous dysplasia (FD) accounts for 7% of benign bone tumors.
  • It is a developmental disorder of unclear etiology.
  • The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue.
  • We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Molecular Mimicry. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Skull / pathology. Skull / radionuclide imaging

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  • (PMID = 19033807.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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19. Romeo S, Szuhai K, Nishimori I, Ijszenga M, Wijers-Koster P, Taminiau AH, Hogendoorn PC: A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes. BMC Cancer; 2009;9:393
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  • BACKGROUND: Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males.

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  • (PMID = 19903358.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2778658
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20. Moon JH, Yoon DY, Choi CS, Yun EJ, Park SJ, Seo YL, Kim BJ: Bilateral ocular osseous choristomas. Pediatr Radiol; 2005 Nov;35(11):1145-6
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  • [Title] Bilateral ocular osseous choristomas.
  • Choristoma is a benign tumour defined as normal tissue in an ectopic location.
  • Osseous choristoma, one subtype of this entity, occurring within the orbit has rarely been reported in the world literature.
  • We report a 6-year-old girl with bilateral ocular osseous choristomas who presented with palpable nodules protruding from both upper lids.
  • [MeSH-major] Bone Diseases / diagnostic imaging. Choristoma / diagnostic imaging. Eye Diseases / diagnostic imaging

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  • [ErratumIn] Pediatr Radiol. 2005 Dec;35(12):1295. Yoon, Eun Joo [corrected to Yun, Eun Joo]
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  • (PMID = 16001272.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E: Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Ups J Med Sci; 2008;113(2):209-16
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  • Eosinophilic granuloma (EG) is a benign tumor-like condition which is characterized by a clonal proliferation of Langerhans-type histiocytes and defined as a local form of Langerhans cell histiocytosis (LCH).
  • A status of EG in the bone is divided into acute and chronic phases.
  • Radiologically acute phase of EG is difficult to differentiate from a malignant bone tumor such as Ewing's sarcoma or acute osteomyelitis.
  • Chronic phase of EG may mimic a chronic osteomyelitis or a benign bone tumor.
  • These lesions resembled radiologically chronic osteomyelitis (Brodie's abscess) or a benign bone tumor and healed spontaneously after biopsy.
  • It was difficult to differentiate from a malignant tumor such as Ewing's sarcoma, or acute osteomyelitis.
  • Curettage of the affected site and bone grafting is usually accomplished.
  • [MeSH-major] Bone Neoplasms / complications. Eosinophilic Granuloma / etiology. Osteomyelitis / complications. Pelvis

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  • (PMID = 18509815.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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22. Freschi S, Dodson NB: Osteoid osteoma: an uncommon cause of foot pain. J Am Podiatr Med Assoc; 2007 Sep-Oct;97(5):405-9
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  • An osteoid osteoma located in the forefoot can be difficult to diagnose, and the diagnosis is frequently delayed.
  • Although rarely seen in the metatarsal, osteoid osteoma should be included in the differential diagnosis of foot pain.
  • Findings from radiographs, magnetic resonance images, and a detailed clinical history led to the diagnosis of osteoid osteoma of the left second metatarsal.
  • We review osteoid osteoma, including the classic clinical presentation and treatment associated with this benign bone tumor.

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  • (PMID = 17901347.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Gümgüm S, Hoşgören B: Clinical and radiologic behaviour of ameloblastoma in 4 cases. J Can Dent Assoc; 2005 Jul-Aug;71(7):481-4
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  • Ameloblastoma is a benign but locally aggressive epithelial odontogenic neoplasm.
  • It represents 1% of all tumours of the jaw bone.
  • It can be treated by enucleation, bone curettage or wide resection.
  • We describe the clinical and radiologic behaviour of ameloblastoma and discuss treatment protocols and the possibility of conservative management of this tumour.

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  • (PMID = 16026635.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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24. Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, Cheepsattayakorn R, Ya-In C, Thorner PS: Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai; 2006 Jun;89(6):780-7
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  • [Title] Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases.
  • OBJECTIVE: The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors.
  • MATERIAL AND METHOD: A retrospective study of the 1,001 bone tumor specimens from the files at the Pathology Department of the Chiang Mai University Hospital, Thailand from 2000 to 2004.
  • RESULTS: From the study, 41 were non-neoplastic mass lesions, and 960 were neoplastic, with 856 (89%) as primary and 104 (11%) as metastatic tumors.
  • In the primary tumor group, 654 (76%) cases were of hematologic origin, and 202 (24%) were non-hematologic.
  • The most common benign bone tumors were giant cell tumor (n = 37), osteochondroma (n = 25), and chondroma (n = 15).
  • The most common malignant bone tumors were lymphoma-leukemia (n = 583), metastatic malignancy (n = 104), plasma cell myeloma (n = 71), and osteosarcoma (n = 58).
  • CONCLUSION: The present study showed a higher frequency of osteosarcoma (68%), lower frequencies of chondrosarcoma (12%) and Ewing sarcoma (4%) among primary non-hematologic malignant bone tumors when compared with similar studies based on Western patients.
  • [MeSH-major] Bone Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Giant Cell Tumors / diagnosis. Giant Cell Tumors / epidemiology. Hospitals, University. Humans. Infant. Male. Middle Aged. Osteochondroma / diagnosis. Osteochondroma / epidemiology. Osteosarcoma / diagnosis. Osteosarcoma / epidemiology. Retrospective Studies. Thailand / epidemiology. World Health Organization

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  • (PMID = 16850677.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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25. Klingenberg L, Konradsen L: [Osteoid osteoma in the hip of 12-year-old girl]. Ugeskr Laeger; 2008 Dec 8;170(50):4142
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  • Osteoid osteoma is a benign skeletal tumour most commonly located in the cortex of long bones and easily diagnosed with distinct symptoms and radiographic appearance.
  • This often leads to a delay in the final diagnosis and treatment.
  • [MeSH-major] Bone Neoplasms. Osteoma, Osteoid
  • [MeSH-minor] Acetabulum / radiography. Child. Diagnosis, Differential. Female. Humans. Laser Therapy

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  • (PMID = 19091196.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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26. Machado I, Giner F, Mayordomo E, Carda C, Navarro S, Llombart-Bosch A: Tissue microarrays analysis in chondrosarcomas: light microscopy, immunohistochemistry and xenograft study. Diagn Pathol; 2008;3 Suppl 1:S25
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  • BACKGROUND: Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone and can be primary or secondary, the latter results mainly from the malignant transformation of a benign pre-existing tumour.
  • METHODS: All the cases diagnosed as Chs (primary tumours, recurrences and/or metastasis and xenotransplanted Chs) from the files of our Department were collected.
  • Six Tissue Microarrays (TMAs) were performed and all the cases and biopsies were distributed into the following groups: a) only paraffin block available from primary and/or metastatic tumours (3 TMAs), b) paraffin block available from primary and/or metastatic tumours as well as from the corresponding Nude mice xenotransplant (2 TMAs), c) only paraffin block available from xenotransplanted Chs (1 TMA).
  • RESULTS: The distribution of the cases according to the histopathological pattern and the location of tumours were as follows: fourteen Grade I Chs (all primaries), two primary Grade II Chs, ten Grade III Chs (all primaries), five dedifferentiated Chs (four primaries and one primary with metastasis), and two Chs from cell cultures (Ch grade III).
  • Curiously, in Grade I Chs, these implanted tumours hardly grew, and the number of passages did not exceed one.
  • Xenotransplanted tumours in TMA improve knowledge concerning the variability in the morphological pattern shown by these tumours during the evolution in nudes.

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  • (PMID = 18673514.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2500106
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27. Asavamongkolkul A, Waikakul S, Phimolsarnti R, Kiatisevi P: Functional outcome following excision of a tumour and reconstruction of the distal radius. Int Orthop; 2009 Feb;33(1):203-9
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  • [Title] Functional outcome following excision of a tumour and reconstruction of the distal radius.
  • We retrospectively studied the functional and oncological results of 15 patients after reconstruction of the distal radius with osteoarticular allograft or non-vascularised fibular graft following wide excision of an aggressive benign or malignant tumour.
  • There was no tumour recurrence after follow up over 41.5-95.5 (average 60.5) months.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Giant Cell Tumor of Bone / surgery. Histiocytoma, Malignant Fibrous / surgery. Osteosarcoma / surgery. Radius / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts / surgery. Bone Plates. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 17724593.001).
  • [ISSN] 1432-5195
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899238
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28. Uysal A, Kayiran O, Cuzdan SS, Bektas CI, Aslan G, Caydere M: Maxillary sinus lipoma: an unanticipated diagnosis. J Craniofac Surg; 2007 Sep;18(5):1153-5
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  • [Title] Maxillary sinus lipoma: an unanticipated diagnosis.
  • Subcutaneous tissue gives rise to numerous lesions such as lipoma, the most common benign soft tissue tumors.
  • Lipoma is seen only extremely rarely in osseous units.
  • In addition, craniofacial involvement of intraosseous lipoma may be misdiagnosed as a fibroosseous tumour such as fibrous dysplasia.
  • Here, we present a case of an intraosseous lipoma obviously destroying and invading the maxillary bone.
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans

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  • (PMID = 17912102.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kelley SP, Ashford RU, Rao AS, Dickson RA: Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J; 2007 Mar;16(3):405-9
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  • [Title] Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry.
  • We conducted a review of the Leeds Regional Bone Tumour Registry for primary bone tumours of the spine since establishment in 1958 until year 2000.
  • To analyse the incidence of primary tumours of the spine and to record the site of occurrence, sex distribution, survival and pathology of these tumours.
  • Primary tumours of the spine are particularly rare, accounting for between 4 and 13% of published series of primary bone tumours.
  • The Leeds Bone Tumour Registry was reviewed and a total of 2,750 cases of bone tumours and tumour-like cases were analysed.
  • Primary bone tumours of the osseous spine constitute only 126 of the 2,750 cases (4.6%).
  • Chordoma was the most frequent tumour in the cervical and sacral regions, while the most common diagnosis overall was multiple myeloma and plasmacytoma.
  • The mean age of presentation was 42 years and pain was the most common presenting symptom, occurring in 95% of malignant and 76% of benign tumours.
  • Neurological involvement occurred in 52% of malignant tumours and usually meant a poor prognosis.
  • The establishment of Bone Tumour Registries is the only way that sufficient data on large numbers of these rare tumours can be accumulated to provide a valuable and otherwise unavailable source of information for research, education and clinical follow-up.

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  • (PMID = 16865376.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2200710
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30. Roper A, Subar D, Benatar B, Kobbe AE: Osteocartilaginous choristoma: a case report. J Laryngol Otol; 2006 Jul;120(7):E23
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  • A choristoma is a benign tumour-like mass consisting of mature tissue derived from one or more germ cell layers that are foreign to the site at which they are located.
  • [MeSH-major] Bone and Bones. Cartilage. Choristoma / surgery. Pharyngeal Diseases / surgery

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  • [ErratumIn] J Laryngol Otol. 2012 Nov;126(11):1194. Benitar, B [corrected to Benatar, B]
  • (PMID = 16834799.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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31. Arends J, Zuercher G, Dossett A, Fietkau R, Hug M, Schmid I, Shang E, Zander A, Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine: Non-surgical oncology - Guidelines on Parenteral Nutrition, Chapter 19. Ger Med Sci; 2009;7:Doc09
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  • Patients with active tumour disease frequently have insufficient food intake.
  • Tumours may result in varying degrees of systemic pro-inflammatory processes with secondary effects on all significant metabolic pathways.
  • Indications for PN in tumour patients are essentially identical to those in patients with benign illnesses, with preference given to oral or enteral nutrition when feasible.

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  • (PMID = 20049066.001).
  • [ISSN] 1612-3174
  • [Journal-full-title] German medical science : GMS e-journal
  • [ISO-abbreviation] Ger Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 171
  • [Other-IDs] NLM/ PMC2795366
  • [Keywords] NOTNLM ; chemotherapy / radiotherapy / stem cell transplantation / tumour
  • [Investigator] Adolph M; Arends J; Bauer K; Biesalski HK; Bischoff SC; Blumenstein I; Bockenheimer-Lucius G; Boehles HJ; Bolder U; Brass P; Celik I; Dossett A; Druml W; Ebener Ch; Fietkau R; Franken Ch; Frewer A; Fusch Ch; Goeters Ch; Hartl W; Hauner H; Hausser L; Heller AR; Holland-Cunz S; Hug MJ; Jauch KW; Jochum F; Kemen M; Kester L; Kierdorf H; Koch T; Koletzko B; Koller M; Kopp IB; Kraehenbuehl L; Krawinkel M; Kreymann G; Krohn K; Kuse ER; Laengle F; Meier R; Muehlebach S; Muehlhoefer A; Mueller MJ; Ockenga J; Parhofer K; Plauth M; Pscheidl E; Radziwill R; Rittler P; Rittler S; Rothaermel S; Schmid I; Schregel W; Schulz RJ; Schuetz T; Schwab D; Senkal M; Shang E; Stanga Z; Stein J; Thul P; Traeger K; Verwied-Jorky S; Volk O; Wehkamp KH; Weimann A; Zander AR; Zuercher G
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32. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7
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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Shears E, Dehne K, Murata H, Abudu A, Grimer RJ, Tillman RM, Carter SR: Healing of ungrafted bone defects of the talus after benign tumour removal. Foot Ankle Surg; 2008;14(3):161-5
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  • [Title] Healing of ungrafted bone defects of the talus after benign tumour removal.
  • BACKGROUND: Curettage of benign tumours commonly results in significant bone defects that are reconstructed with autologous grafts, allografts, bone cement or bone substitute.
  • We have treated such defects in the talus without reconstruction with bone or any other material.
  • We now report the healing of these ungrafted defects in eight patients treated with curettage for benign talar tumours.
  • CONCLUSIONS: We conclude that bone grafting is not a necessary adjunct to the curettage of talar lesions.
  • [MeSH-major] Bone Neoplasms / surgery. Talus / surgery. Wound Healing

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  • (PMID = 19083636.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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34. Arantes M, Resende M, Honavar M, Pires MM, Pereira JR, Vaz AR: Benign osteoblastoma of the sphenoid bone. Skull Base; 2009 Nov;19(6):437-41
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  • [Title] Benign osteoblastoma of the sphenoid bone.
  • Osteoblastoma is an uncommon benign bone tumor that accounts for 1% of all primary bone tumors.
  • Well documented in the spine and long bones, it is rarely found in the skull, namely in the sphenoid bone, with only five cases reported in the literature.
  • We report a case of an 11-year-old girl with a histologically confirmed benign osteoblastoma in an unusual location and an atypical aspect on the imaging studies.

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  • [Cites] Cancer. 1956 Sep-Oct;9(5):1044-52 [13364889.001]
  • (PMID = 20436846.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793891
  • [Keywords] NOTNLM ; Benign osteoblastoma / child / radical resection / sphenoid bone
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35. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am; 2009 Aug;17(3):469-87, vi
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  • [Title] MR imaging of primary bone tumors and tumor-like conditions in children.
  • This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population.
  • Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma.
  • Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis.
  • The use of MR imaging in the diagnosis of these lesions is discussed, and the text is enhanced with imaging examples of the lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Bone Cysts / diagnosis. Bone Cysts / pathology. Cartilage Diseases / diagnosis. Cartilage Diseases / pathology. Child. Contrast Media. Humans

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  • (PMID = 19524197.001).
  • [ISSN] 1557-9786
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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36. Kitsoulis P, Mantellos G, Vlychou M: Osteoid osteoma. Acta Orthop Belg; 2006 Apr;72(2):119-25
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  • Osteoid osteoma is a relatively frequent benign bone tumour, consisting of osteoid and woven bone, and surrounded by a halo of reactive sclerotic bone, with an average size of the nidus less than 1.5 cm.
  • [MeSH-major] Bone Neoplasms. Osteoma, Osteoid

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  • (PMID = 16768252.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 42
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37. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj-Hassouni N: Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine; 2005 Mar;72(2):177-9
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  • Osteochondroma, or exostosis, is the most common of all benign bone tumors.

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  • (PMID = 15797501.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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38. Streitbuerger A, Hardes J, Gebert C, Ahrens H, Winkelmann W, Gosheger G: [Cartilage tumours of the bone. Diagnosis and therapy]. Orthopade; 2006 Aug;35(8):871-81; quiz 882
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  • [Title] [Cartilage tumours of the bone. Diagnosis and therapy].
  • Primary malignant bone tumours are rare.
  • The annual incidence of these tumours is 10 per 1 million.
  • Nearly 30% of the primary malignant bone tumours are malignant cartilage tumours.
  • The frequency of benign cartilage tumours cannot be definitely estimated because these tumours are normally clinically inapparent and therefore often diagnosed as an incidental finding.
  • The cartilage tumours appear as benign lesions (e.g. chondroma), as borderline tumours (proliferative chondroma vs grade I chondrosarcoma) or as highly malignant chondrosarcoma (e.g. dedifferentiated chondrosarcoma).
  • Commensurate with the different clinical and oncological manifestations of the cartilage tumours, there are wide differences in the treatment and clinical course of the individual tumour.
  • This article discusses the problems in the diagnosis and treatment of cartilage tumours from an orthopaedic point of view.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Chondroblastoma / diagnosis. Chondroblastoma / therapy. Chondroma / diagnosis. Chondroma / therapy. Chondrosarcoma / diagnosis. Chondrosarcoma / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians'

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  • (PMID = 16865383.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopäde
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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39. Santiago FR, Del Mar Castellano García M, Montes JL, García MR, Fernández JM: Treatment of bone tumours by radiofrequency thermal ablation. Curr Rev Musculoskelet Med; 2009 Mar;2(1):43-50
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  • [Title] Treatment of bone tumours by radiofrequency thermal ablation.
  • Other benign conditions (chondroblastoma, osteoblastoma, giant cell tumour, etc.) can also be treated by this technique, which is less invasive than traditional surgical procedures.
  • In other cases, it is combined with conventional therapies or other percutaneous treatments, e.g., cementoplasty, offering faster pain relief and bone strengthening.

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  • (PMID = 19468917.001).
  • [ISSN] 1935-973X
  • [Journal-full-title] Current reviews in musculoskeletal medicine
  • [ISO-abbreviation] Curr Rev Musculoskelet Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2684952
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40. Xu J, Xu CR, Wu H, Pan HL, Tian J: Osteochondroma in the lumbar intraspinal canal causing nerve root compression. Orthopedics; 2009 Feb;32(2):133
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  • Osteochondromas, which are benign bone tumors that usually develop on long bones, tubular bones, are rarely found in the spine.
  • Considering differential diagnosis, lumbar facet synovial cysts must be excluded as they can also cause myeloradiculopathy with the similar mechanism.
  • The tumor, approximately 6x7x11 mm, was identified after laminectomy of the L5 laminae.
  • Postoperative histopathologic examination confirmed our hypothesis of benign osteochondroma.
  • Computed tomography and MRI are helpful for the preoperatively precise indication of tumor extent and its relationships with the adjacent.

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  • (PMID = 19301786.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Kim J, Kumar R, Raymond AK, Ayala AG: Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature. Skeletal Radiol; 2010 Jun;39(6):583-7
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  • [Title] Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature.
  • Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone.
  • We describe such a case of chondroblastoma arising in the iliac bone.
  • The radiographs and CT revealed an expansile lytic lesion in the right iliac bone.
  • The histopathology revealed the lesion to be a chondroblastoma with secondary features of aneurysmal bone cyst.
  • An en bloc surgical resection of the tumor was performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / complications. Bone Cysts, Aneurysmal / diagnostic imaging. Bone Neoplasms / complications. Bone Neoplasms / diagnostic imaging. Chondroblastoma / complications. Chondroblastoma / diagnostic imaging. Ilium / diagnostic imaging. Tomography, X-Ray Computed

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  • (PMID = 19936740.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 12
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42. Bala A, Robbins P, Knuckey N, Wong G, Lee G: Spinal chondromyxoid fibroma of C2. J Clin Neurosci; 2006 Jan;13(1):140-6
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  • Chondromyxoid fibroma of bone (CMF) is a rare benign primary bone neoplasm accounting for less than 0.5% of all primary bone neoplasms.
  • The spine is an uncommon site for this tumour, with forty-two cases reported in the modern English literature.
  • The patient underwent stereotactic CT guided trans-oral curettage of the lesion with iliac bone graft and anterior fusion of C2 and C3.
  • This is the second reported case of this rare tumour in this location.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Fibroma / pathology. Spinal Neoplasms / pathology

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  • (PMID = 16410218.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 39
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43. Figl M, Leixnering M: Retrospective review of outcome after surgical treatment of enchondromas in the hand. Arch Orthop Trauma Surg; 2009 Jun;129(6):729-34
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  • BACKGROUND: Tumours of the skeleton of the hand are rare.
  • While the majority of bone tumours are benign (89.4%), a small number show signs of malignancy (4.4%).
  • Among the benign bone tumours of the skeleton of the hand, enchondromas are the most common, at 35-65%.
  • The most common site of an enchondroma was the proximal phalanx in 17 cases, followed by the metacarpal bone in 8 cases and the middle phalanx in 5 cases.
  • For accurate diagnosis, conventional X-ray examination and if necessary, a contrast medium MRI should be performed.
  • Depending on its spread, the defect in the extirpation cavity should be filled with autogenous spongy bone.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Hand / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Transplantation. Female. Fingers / pathology. Fingers / surgery. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / pathology. Fractures, Spontaneous / surgery. Hand Injuries / diagnosis. Hand Injuries / pathology. Hand Injuries / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18726106.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Leiser Y, Abu-El-Naaj I, Peled M: Odontogenic myxoma--a case series and review of the surgical management. J Craniomaxillofac Surg; 2009 Jun;37(4):206-9
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  • BACKGROUND: Odontogenic myxomas (OMs) are considered to be a benign odontogenic tumour with locally aggressive behaviour.
  • [MeSH-major] Mandibular Neoplasms / surgery. Maxillary Neoplasms / surgery. Odontogenic Tumors / surgery
  • [MeSH-minor] Adult. Bone Plates. Bone Screws. Curettage. Female. Follow-Up Studies. Humans. Male. Maxillary Sinus / surgery. Middle Aged. Neoplasm Recurrence, Local / surgery. Orbit / surgery. Osteotomy. Palatal Obturators. Reconstructive Surgical Procedures

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  • (PMID = 19027311.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 26
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45. De Marchi A, Brach del Prever EM, Linari A, Pozza S, Verga L, Albertini U, Forni M, Gino GC, Comandone A, Brach del Prever AM, Piana R, Faletti C: Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours. Eur Radiol; 2010 Nov;20(11):2740-8
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  • [Title] Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours.
  • OBJECTIVE: Percutaneous biopsies are gaining acceptance in the diagnosis of soft-tissue tumours.
  • Accuracy of US-guided CNB after contrast-enhanced US (CEUS) was determined by comparing the histology of the biopsy with the definitive diagnosis in 105 surgically excised samples (42 benign, 63 malignant) and with the expected outcome in the remaining ten malignant cases not surgically treated.
  • RESULTS: Of samples, 94.8% were adequate for diagnosis with 97.1% sensitivity and 92.5% specificity.
  • US contrast medium depicts tumour vascular supply and identifies the representative area(s) for sampling.
  • Discussion about biopsy is part of the essential multidisciplinary strategy for these tumours.

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  • (PMID = 20582701.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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46. Rodríguez Paramás A, Lendoiro Otero C, González García JA, Souviron Encabo R, Scola Yurrita B: [Temporal bone chondroblastoma. A clinical case and literature review]. Acta Otorrinolaringol Esp; 2006 Aug-Sep;57(7):336-8
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  • [Title] [Temporal bone chondroblastoma. A clinical case and literature review].
  • [Transliterated title] Condroblastoma de hueso temporal. Caso clínico y revisión de la literatura.
  • After radiologic diagnosis, intraoperatory biopsy and surgical removal, the anatomopathological result confirmed the histology of chondroblatoma, with a satisfactory postoperative evolution.
  • The chondroblastoma is a benign bone tumor typically located in the epiphysis of long bones and the temporal bone is an excepcional location as we have verified through a literature review.
  • [MeSH-major] Chondroblastoma. Skull Neoplasms. Temporal Bone

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  • (PMID = 17036998.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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47. Abdulkareem FB, Eyesan SU, Akinde OR, Ezembakwe ME, Nnodu OE: Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med; 2007 Oct-Dec;26(4):306-11
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  • [Title] Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria.
  • BACKGROUND: Although primary bone tumours are relatively uncommon, they constitute the most important tumours in patients under 20 years.
  • OBJECTIVE: To update the literature on the relative frequency and clinico-pathologic characteristics of bone tumours in this environment.
  • MATERIALS AND METHODS: The clinical and histopathological records of patients presenting with diagnosis of bone tumours between 1999 and 2004 and managed at the National Orthopaedic Hospital, Igbobi, (NOHI) Lagos, Nigeria were review and where necessary, new ones were prepared from the paraffin blocks and stained with routine haematoxylin and eosin stain.
  • RESULTS: Seventy-seven cases were recorded; 61 (79.2%) benign and 16 (15.6%) malignant.
  • The male:female ratio for all tumours was 2:1.
  • The commonest benign bone tumours were osteochondroma and giant cell tumour accounting for 52 (67%) of all cases with > 60% in males.
  • The most common primary malignant bone tumour was osteosarcoma, all in males.
  • Four (5.2%) cases of metastatic bone tumours located commonly in the proximal femur and humerus were also recorded.
  • CONCLUSION: Osteochondroma and giant cell tumours are the commonest benign tumours while osteosarcoma is the most common primary bone tumour all occurring in the first two decades of life.
  • [MeSH-major] Bone Neoplasms / pathology

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  • (PMID = 18705432.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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48. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9
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  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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49. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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50. Aldea S, Bonneville F, Poirier J, Chiras J, George B, Carpentier A: Acute spinal cord compression in hereditary multiple exostoses. Acta Neurochir (Wien); 2006 Feb;148(2):195-8; discussion 198
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  • Osteocartilaginous exostoses are benign bone tumors frequently found in the metaphysis of long bones but rarely in the spine.


51. Klenke FM, Merkle T, Fellenberg J, Abdollahi A, Huber PE, Gebhard MM, Ewerbeck V, Sckell A: A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy. Lab Anim; 2005 Oct;39(4):377-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy.
  • Here is reported the development of an experimental model using intravital microscopy as a tool to orthotopically investigate malignant bone tumours.
  • Although up to 85% of the most frequently occurring malignant solid tumours, such as lung and prostate carcinomas, metastasize into the bone, and despite the knowledge that a tumour's course may be altered by its surrounding tissue, there is no adequate experimental model available enabling the investigation of orthotopically grown bone tumours in vivo.
  • Intravital microscopy is an internationally accepted experimental method, used in various acute and chronic animal models, that enables qualitative and quantitative analysis of the angiogenesis, microcirculation, growth behaviour, etc. of various benign and malignant tissues.
  • Severe combined immunodeficient mice were fitted with a cranial window preparation where the calvaria served as the site for orthotopic implantation of the solid human tumours Saos-2 osteosarcoma (primary) and A 549 lung carcinoma and PC-3 prostate carcinoma (secondary).
  • Histological assessment confirmed the data obtained in vivo, showing typical tumour growth with infiltration of the surrounding osseous and soft tissues.
  • This novel model serves as a valuable tool in understanding the biology of primary and secondary bone tumours in physiological and pathophysiological situations, with implications for the most areas of tumour therapy such as chemotherapy, radiation and antiangiogenesis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Animals. Lung Neoplasms / pathology. Male. Mice. Mice, SCID. Microscopy, Fluorescence. Microscopy, Video. Neoplasm Transplantation. Neovascularization, Pathologic / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16197704.001).
  • [ISSN] 0023-6772
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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52. Sakai H, Mori T, Iida T, Tokuma Y, Maruo K, Masegi T: Immunohistochemical features of proliferative marker and basement membrane components of two feline inductive odontogenic tumours. J Feline Med Surg; 2008 Jul;10(3):296-9
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  • [Title] Immunohistochemical features of proliferative marker and basement membrane components of two feline inductive odontogenic tumours.
  • Feline inductive odontogenic tumour (FIOT) is a rare and interesting odontogenic neoplasm in which the odontogenic epithelium has inductive potential to form aggregated foci of dental pulp-like mesenchymal cells.
  • Histopathologically, the masses consisted of non-encapsulated invasive neoplasms exhibiting proliferation of epithelial and mesenchymal components with local infiltration into the maxillary bone in both cases.
  • Type IV collagen and laminin were constantly positive around the foci of epithelial cells, and Ki-67 positive indices were extremely low; therefore, these findings consistent with the benign clinical presentation of FIOT.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / immunology. Mandibular Neoplasms / veterinary. Odontogenic Tumors / veterinary

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  • (PMID = 17766158.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Collagen Type IV; 0 / Ki-67 Antigen
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53. Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM: Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol; 2010 Jan;220(1):24-33
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  • Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis.
  • Therefore, in this study, we examined nuclear beta-catenin expression in 52 human osteosarcoma biopsies, 15 osteoblastomas (benign bone tumours), and four human osteosarcoma cell lines by immunohistochemistry.
  • Stimulation of the Wnt/beta-catenin pathway by GIN significantly reduced cell proliferation in the cell lines MG-63 and U-2-OS and enhanced differentiation in the cell lines HOS and SJSA-1, as shown by an increase in alkaline phosphatase (ALP) activity and mineralization.
  • [MeSH-major] Bone Neoplasms / physiopathology. Osteosarcoma / physiopathology. Wnt Proteins / physiology. beta Catenin / metabolism
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Proliferation. Glycogen Synthase Kinase 3 / antagonists & inhibitors. Glycogen Synthase Kinase 3 / physiology. Hedgehog Proteins / physiology. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mice. Neoplasm Proteins / metabolism. Neoplasm Proteins / physiology. Osteoblasts / pathology. Recombinant Proteins / pharmacology. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / drug effects. Signal Transduction / physiology. Tumor Cells, Cultured. Wnt3 Protein

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  • [CommentIn] J Pathol. 2010 Jan;220(1):1-4 [19890890.001]
  • (PMID = 19882675.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DKK1 protein, human; 0 / Hedgehog Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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54. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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55. Baranović M, Macan D, Begović EA, Luksic I, Brajdić D, Manojlović S: Schwannoma with secondary erosion of mandible: case report with a review of the literature. Dentomaxillofac Radiol; 2006 Nov;35(6):456-60
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  • Schwannoma (neurilemmoma) is a common, histologically distinctive, benign, usually encapsulated, peripheral nerve tumour of Schwann cell origin.
  • It was impossible to determine prior to surgery whether this was a peripheral nerve sheath tumour.
  • The lesion was completely removed; the tumour appears to have originated in soft tissue and caused secondary erosion of the mandible.
  • [MeSH-minor] Bone Resorption / etiology. Female. Humans. Middle Aged

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  • (PMID = 17082339.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
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56. Mir NA, Baba AN, Maajid S, Badoo AR, Mir GR: Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features. Foot Ankle Surg; 2010 Jun;16(2):e24-6
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  • Osteoblastoma is a benign bone tumour found commonly in the spine and long tubular bones.
  • Analysis of clinical, radiological and histological findings confirmed the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / radiography. Osteoblastoma / radiography. Rare Diseases. Talus. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Osteotomy / methods

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483122.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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57. Izci Y: Management of the large cranial osteoma: experience with 13 adult patients. Acta Neurochir (Wien); 2005 Nov;147(11):1151-5; discussion 1155
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  • BACKGROUND: Large osteomas are benign, slow-growing and rare neoplasms of the skull, which are usually asymptomatic but may need surgical resection.
  • FINDINGS: Craniectomy associated with cranioplasty was performed in 10 patients and drilling of the bone tumor was performed in 3 patients.
  • Tumour regrowth was not observed in any patient.
  • [MeSH-minor] Acrylates / adverse effects. Acrylates / therapeutic use. Adult. Frontal Bone / pathology. Frontal Bone / radiography. Frontal Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Parietal Bone / pathology. Parietal Bone / radiography. Parietal Bone / surgery. Polyethylene / therapeutic use. Prostheses and Implants / trends. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods. Reconstructive Surgical Procedures / statistics & numerical data. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16133777.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Acrylates; 9002-88-4 / Polyethylene
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58. Katthagen BD, Prub A: [Bone allografting]. Orthopade; 2008 Aug;37(8):764-71
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  • [Title] [Bone allografting].
  • [Transliterated title] Transplantation allogenen Knochens.
  • Bone allografts facilitate bone reconstruction in orthopedic surgery.
  • After implantation, bone allografts become necrotic but are incorporated and remodeled in the recipient bone with good regenerative capacity.
  • We use bone allografts in about 3% of all elective orthopedic operations in our hospital.
  • We use bone allografts regularly in acetabuloplasty in cases of severe residual hip dysplasia.
  • Bone allografts are most often used in revision total joint arthroplasty.
  • In cases of reconstruction of defects in benign bone tumors and tumor-like lesions, bone allografts are often suitable.
  • In fibrous dysplasia, corticocancellous bone allografts are even the treatment of choice.
  • [MeSH-major] Bone Transplantation / methods. Orthopedic Procedures
  • [MeSH-minor] Acetabulum / surgery. Adult. Arthroplasty, Replacement. Bone Banks. Bone Neoplasms / surgery. Bone Regeneration. Bone Remodeling / physiology. Child. Disinfection. Follow-Up Studies. Hip Dislocation, Congenital / surgery. Humans. Prosthesis Failure. Reoperation. Transplantation, Homologous

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  • [Cites] Clin Orthop Relat Res. 1968 Nov-Dec;61:61-78 [4236465.001]
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  • (PMID = 18584151.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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59. Abou-Elhamd KE: Frontal sinus cementifying ossifying fibroma. Saudi Med J; 2005 Mar;26(3):470-2
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  • Cementifying ossifying fibroma is a fibro-osseous lesion which produces cementum.
  • Cementifying ossifying fibroma is a mesodermal, non-odontogenic tumor of ectopic multipotential periodontal membrane blast cells.
  • Although, it is a benign bone tumor, it has an aggressive destructive behavior in patients under 20 years of age with high tendency for recurrence.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibroma, Ossifying / diagnosis. Frontal Sinus

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  • (PMID = 15806222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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60. Gebert C, Brinkschmidt C, Bielack S, Bernhardt T, Jürgens H, Böcker W, Winkelmann W, Bürger H, Gosheger G: The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions. Int J Surg Pathol; 2006 Jul;14(3):187-92
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  • [Title] The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Matrix-producing bone lesions consist of a wide variety of benign and malignant conditions.
  • With respect to morphology, an overlap exists between benign and malignant bone tumors that causes difficulties in the final determination of the tumor.
  • This study was conducted to show the potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Thirty benign bone tumors were evaluated by conventional comparative genomic hybridization.
  • In contrast benign tumors or tumor-like lesions did not reveal any chromosomal alterations.
  • Comparative genomic hybridization is a useful adjunct in the complicated differential diagnostic algorithms of matrix-producing bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chromosome Aberrations. DNA, Neoplasm / genetics. Molecular Diagnostic Techniques / methods. Osteosarcoma / diagnosis

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  • (PMID = 16959697.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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61. Hanna SA, David LA, Aston WJ, Gikas PD, Blunn GW, Cannon SR, Briggs TW: Endoprosthetic replacement of the distal humerus following resection of bone tumours. J Bone Joint Surg Br; 2007 Nov;89(11):1498-503
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  • [Title] Endoprosthetic replacement of the distal humerus following resection of bone tumours.
  • Between 1988 and 2006, 18 patients had a custom-made endoprosthetic replacement of the distal humerus for bone tumours at our institution.
  • There were 11 primary malignant neoplasms, six secondary deposits, and one benign aggressive tumour.
  • The 11 living patients were evaluated using the Musculoskeletal Tumour Society and Toronto Extremity Salvage scoring systems.
  • Custom-made endoprosthetic reconstruction of the elbow for bone tumours is a viable treatment in carefully selected patients.
  • [MeSH-major] Arthroplasty, Replacement / methods. Bone Neoplasms / surgery. Humerus / surgery

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  • (PMID = 17998189.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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62. Bernard-Pierrot I, Brams A, Dunois-Lardé C, Caillault A, Diez de Medina SG, Cappellen D, Graff G, Thiery JP, Chopin D, Ricol D, Radvanyi F: Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis; 2006 Apr;27(4):740-7
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  • Germinal activating mutations of FGFR3 are responsible for several forms of dwarfism due to the inhibitory effect of FGFR3 on bone growth.
  • Surprisingly, identical somatic activating mutations have been found at the somatic level in tumours: at high frequency in benign epithelial tumours (seborrheic keratosis, urothelial papilloma) and in low-grade, low-stage urothelial carcinomas, and at a lower frequency in other types of urothelial carcinoma, in cervix carcinoma, and in haematological cancer, multiple myeloma.
  • FGFR3b is the main form in epithelial cells and derived tumours, whereas FGFR3c is the main form in mesenchyme-derived cells and multiple myeloma.
  • Although mutated FGFR3b is mostly found in benign epithelial tumours or carcinomas of low malignant potential, we present evidence here that mutated FGFR3b is oncogenic.
  • All bladder tumours presenting FGFR3 mutations expressed this receptor more strongly than normal urothelium or non-mutated tumours.
  • NIH-3T3 cells transfected with a mutated form of FGFR3b--FGFR3b-S249C, the most common mutation in bladder tumours--presented a spindle-cell morphology, grew in soft agar and gave rise to tumours when xenografted into nude mice.
  • We showed using siRNA and SU5402, an FGFR inhibitor, that the tumour properties of MGH-U3 depended on mutated receptor activity.

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  • (PMID = 16338952.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Pyrroles; 0 / RNA, Small Interfering; 0 / SU 5402; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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63. Hopyan S, Ngan SY, Choong PF: Natural history of tumour-related sacral obliteration with nerve-root preservation. Clin Oncol (R Coll Radiol); 2005 May;17(3):195-8
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  • [Title] Natural history of tumour-related sacral obliteration with nerve-root preservation.
  • Benign aggressive bone tumours can present a dilemma when the definitive treatment options necessitate enormous and permanent functional deficits.
  • Here, we present a case of a massive sacral giant-cell tumour causing dramatic skeletal obliteration, which was successfully treated with radical radiotherapy rather than ablative surgery.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Giant Cell Tumor of Bone / radiotherapy. Sacrum

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  • (PMID = 15901005.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Delgrange E, Sassolas G, Perrin G, Jan M, Trouillas J: Clinical and histological correlations in prolactinomas, with special reference to bromocriptine resistance. Acta Neurochir (Wien); 2005 Jul;147(7):751-7; discussion 757-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Prolactinomas usually exhibit a benign course and can be safely and effectively managed by dopamine agonists (DA).
  • The prolactinomas were categorized on the basis of tumour size (48 macroadenomas), invasion of the cavernous sinus (n = 31), and resistance to bromocriptine (BRC) therapy (n = 14).
  • Group 1 consisted of non-invasive microprolactinomas (n = 24), group 2 of non-invasive macroprolactinomas (n = 19), group 3 of invasive non-BRC-resistant tumours (n = 19), and group 4 of invasive BRC-resistant tumours (n = 12).
  • The later group included one case of carcinoma with bone and lung metastases.
  • Tumour size and invasion were related to cellular atypia and the Ki-67 LI.
  • BRC-resistant tumours were more frequently invasive (12/14) than BRC-responsive tumours (11/30; p = 0.002) and were more frequent in men than in women (33 versus 5%; p = 0.003).
  • BRC-resistant tumours had a higher Ki-67 LI and mitotic count (4.2+/-2.0% and 4+/-1, respectively) than other tumours (0.7+/-0.2% and 1+/-0, respectively; p<0.05).
  • These findings justify the long-term follow up of these tumours, and the use of surgery and/or radiotherapy if there is concern about the control of tumour growth.
  • [MeSH-minor] Adult. Aged. Drug Resistance. Female. Humans. Hypophysectomy. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Male. Middle Aged. Mitotic Index. Neoplasm Invasiveness / pathology. Neoplasm Staging. Pituitary Gland / pathology. Retrospective Studies. Sex Factors

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  • (PMID = 15971099.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Dopamine Agonists; 0 / Ki-67 Antigen; 3A64E3G5ZO / Bromocriptine
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65. Fraquet N, Faizon G, Rosset P, Phillipeau J-, Waast D, Gouin F: Long bones giant cells tumors: treatment by curretage and cavity filling cementation. Orthop Traumatol Surg Res; 2009 Oct;95(6):402-6
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  • [Title] Long bones giant cells tumors: treatment by curretage and cavity filling cementation.
  • OBJECTIVE: Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage.
  • Twenty-six of these tumors were present around the knee: 14 at the distal femur and 12 at the proximal tibia.
  • Preoperative radiological evaluation with standard X-rays showed that the tumor measured a mean 71x45mm, for a mean volume of 78cm(3).
  • Two cases of minor osteoarthritis progression were noted (one less than 50% and a simple densification of subchondral bone), requiring no specific treatment.
  • Diagnosis of recurrence can be made earlier because of the thin scalable border at the bone-cement interface.
  • [MeSH-major] Bone Cements / therapeutic use. Bone Neoplasms / surgery. Femur / surgery. Giant Cell Tumor of Bone / surgery. Orthopedic Procedures / methods. Tibia / surgery

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19767256.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
  • [General-notes] NLM/ Original DateCompleted: 20100201
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66. Kim WJ, Kim KJ, Lee SK, Choy WS: Solitary pelvic osteochondroma causing L5 nerve root compression. Orthopedics; 2009 Dec;32(12):922
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  • Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors.
  • Thus, surgical excision is not routinely recommended unless the tumor causes clinical symptoms or cosmetic distress.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / surgery. Decompression, Surgical / methods. Osteochondroma / complications. Osteochondroma / surgery. Pelvic Bones / radiography. Pelvic Bones / surgery. Radiculopathy / etiology. Radiculopathy / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968229.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Meli GA, Meli L, Chiaramonte R, Riva G, Pero G: Osteoblastoma of the orbit. A case report and review of the literature. Neuroradiol J; 2008 Feb 18;21(1):71-6
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  • We describe a case of benign orbital tumour involving the frontal sinus and ethmoidal cells.
  • CT findings were typical of "bone tumour of the orbit", histological analysis yielded a diagnosis of benign osteoblastoma.
  • The orbit is rarely involved by bone tumours, but all bone tumours may theoretically involve the orbit, often making it difficult to establish the right differential diagnosis by imaging.
  • For this reason we also examined the radiological signs of bone tumours involving other portions of the body.
  • Even though many literature reports suggest CT is the landmark in bone tumour diagnosis, we think it should always be accompanied by MRI.
  • MRI is known to overestimate local staging, but its contribution to differential diagnosis among various tumours may be decisive.

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  • (PMID = 24256752.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Veth R, Schreuder B, van Beem H, Pruszczynski M, de Rooy J: Cryosurgery in aggressive, benign, and low-grade malignant bone tumours. Lancet Oncol; 2005 Jan;6(1):25-34
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  • [Title] Cryosurgery in aggressive, benign, and low-grade malignant bone tumours.
  • Cryosurgery is a method of treatment for various tumours that induces tissue necrosis with ablative intent.
  • It is used in benign, aggressive, and low-grade malignant bone tumours such as chondrosarcoma grade 1.
  • At the University Medical Centre Nijmegen, Netherlands, 302 tumours have been treated by use of cryosurgery with at least 2 years' follow-up.
  • 96-100% of patients were cured-the response depended on tumour type.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Cryosurgery / methods
  • [MeSH-minor] Humans. Neoplasm Staging. Treatment Outcome

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  • (PMID = 15629273.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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69. Ozyurek S, Rodop O, Kose O, Cilli F, Mahirogullari M: Aneurysmal bone cyst of the fifth metacarpal. Orthopedics; 2009 Aug;32(8)
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  • [Title] Aneurysmal bone cyst of the fifth metacarpal.
  • Aneurysmal bone cyst is a rare, rapidly growing, and destructive benign bone tumor that even more rarely involves the bones of the hand.
  • Various treatment options for aneurysmal bone cyst have been reported in the literature, but controversy exists regarding optimal treatment.
  • Physical and radiographic examination of the hand was consistent with aneurysmal bone cyst.
  • After biopsy, pathologic examination confirmed the diagnosis of aneurysmal bone cyst.
  • En-block resection of the tumor and autologous bicortical strut graft fixation with Kirschner wires was performed.
  • Radiographic examination demonstrated the osseous integration of the graft with no signs of recurrence.
  • [MeSH-major] Bone Cysts, Aneurysmal / radiography. Bone Cysts, Aneurysmal / surgery. Bone Transplantation. Metacarpal Bones / radiography. Metacarpal Bones / surgery. Osteotomy

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  • (PMID = 19708623.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Gibbs CP, Lewis VO, Peabody T: Beyond bone grafting: techniques in the surgical management of benign bone tumors. Instr Course Lect; 2005;54:497-503
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  • [Title] Beyond bone grafting: techniques in the surgical management of benign bone tumors.
  • The traditional surgical treatment of benign bone tumors has been curettage and autologous bone graft or marginal resection of expendable bones.
  • Recently, however, surgeons have been evaluating the results of treatments using limited surgical approaches, including percutaneous treatments, alternatives to autograft bone, and thermal or cytotoxic adjuvant therapies.
  • This process has been facilitated by the availability of multiple bone grafting materials and substitutes, the use of cross-sectional imaging, and technology such as that used with radiofrequency ablation.
  • Techniques using these therapies in two benign bone tumor models are described.
  • The use of percutaneous radiofrequency ablation, now used for both benign and malignant disease, is reviewed as a surgical alternative for osteoid osteoma.
  • The role of adjuvant therapies such as liquid nitrogen and phenol, as well as the indications for resection, are described in the management of giant cell tumors of bone.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Giant Cell Tumor of Bone / surgery. Osteoma, Osteoid / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Bone Transplantation / methods. Humans. Prosthesis Implantation / methods

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  • (PMID = 15948474.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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71. Pimenta FJ, Gontijo Silveira LF, Tavares GC, Silva AC, Perdigão PF, Castro WH, Gomez MV, Teh BT, De Marco L, Gomez RS: HRPT2 gene alterations in ossifying fibroma of the jaws. Oral Oncol; 2006 Aug;42(7):735-9
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  • Ossifying fibroma (OF) is a benign neoplasm related to bone characterized by a progressive enlargement of the affected jaw.
  • Recently, the candidate tumor suppressor gene HRPT2 was identified and alterations in this gene were related with the Hyperparathyroidism-jaw tumor syndrome that is characterized by parathyroid adenoma or carcinoma, fibro-osseous lesions (mainly OF) of the jaws, and renal lesions.
  • Tumour and blood samples were obtained from 3 patients with OF and one with juvenile ossifying fibroma (JOF).
  • RT-PCR amplification was performed to analyze HRPT2 mRNA expression and only wild-type HRPT2 transcript was found in all tumours.
  • [MeSH-major] Fibroma, Ossifying / genetics. Genes, Tumor Suppressor. Mandibular Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Gene Expression. Humans. Male. Middle Aged. Mutation. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 16458039.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Tumor Suppressor Proteins
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72. Nahal A, Ajlan A, Alcindor T, Turcotte R: Dedifferentiated giant cell tumour of bone in the form of low-grade fibroblastic osteogenic sarcoma: case report of a unique presentation with follow-up. Curr Oncol; 2010 Aug;17(4):71-6
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  • [Title] Dedifferentiated giant cell tumour of bone in the form of low-grade fibroblastic osteogenic sarcoma: case report of a unique presentation with follow-up.
  • Giant cell tumour (GCT) of bone is a locally aggressive benign tumour.
  • It can, however, undergo dedifferentiation, either de novo or secondarily after local recurrence or radiation.
  • Here, we describe the first case of dedifferentiated GCT in the appearance of low-grade fibroblastic osteogenic sarcoma with distant bone metastases.
  • We confirm the aggressive behaviour of this tumour despite the deceptively bland appearance of the malignant component.

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  • [Cites] Histopathology. 2007 Dec;51(6):864-6 [18042075.001]
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  • (PMID = 20697518.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2913833
  • [Keywords] NOTNLM ; Giant cell tumour / dedifferentiation / malignancy / osteogenic sarcoma
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73. Sparsa A, Bonnetblanc JM, Roux C, Pinet C, Loustaud-Ratti V, Boulinguez S, Labrousse F, Vidal E, Bedane C: [Pyogenic granuloma revealing fistula and deep infection: five cases]. Ann Dermatol Venereol; 2006 Oct;133(10):763-6
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  • BACKGROUND: Pyogenic granuloma, or botryomycosis, occurring after minor injury or scratching with a septic implement, is a rapidly growing benign inflammatory vascular tumour, often involving the skin or mucous membrane.
  • Clinical images were recorded and a diagnosis of botryomycosis was confirmed in all patients by histological analysis.
  • The time from initial clinical signs to diagnosis, presence of traumatic events, screening for microscopic organisms, response to systemic antibiotic therapy, recurrence and clinical features of botriomycosis were analysed.
  • RESULTS: All patients presented botryomycosis with fistula and suppuration revealing deep bone infection and in one patient, pace maker infection.

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  • (PMID = 17072190.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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74. Clézardin P: Anti-tumour activity of zoledronic acid. Cancer Treat Rev; 2005;31 Suppl 3:1-8
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  • [Title] Anti-tumour activity of zoledronic acid.
  • Bisphosphonates are proven to be effective in the treatment of benign or malignant skeletal diseases characterized by enhanced osteoclastic bone resorption.
  • Nitrogen-containing bisphosphonates (N-BPs) have also been demonstrated to exhibit direct anti-tumour effects.
  • They not only inhibit proliferation and induce apoptosis in cultured cancer cells, but additionally interfere with adhesion of cancer cells to the bone matrix and inhibit cell migration and invasion.
  • Growing preclinical evidence shows that zoledronic acid also exhibits direct anti-tumour activity.
  • The overall effects on tumour cells appear to be mediated via diverse pathways, such as apoptosis, angiostasis, cell-cell-interactions and immunomodulation.
  • Higher doses of zoledronic acid or more frequent applications than currently approved may be required to achieve clinically meaningful anti-tumour effects.
  • The future challenge is to focus on optimizing dosing regimens and drug combinations to maximize the anti-tumour potential of zoledronic acid and to take advantage of the observed synergy with standard neoplastic agents.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Density Conservation Agents / therapeutic use. Bone Neoplasms / drug therapy. Diphosphonates / therapeutic use. Imidazoles / therapeutic use

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  • (PMID = 16225995.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 0 / Imidazoles; 6XC1PAD3KF / zoledronic acid
  • [Number-of-references] 43
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75. Löhrer L, Vordemvenne T, Neuber M, Krueger KU, Schult M, Ochman S: [Enchondroma of the hand - treatment and long-term outcome]. Z Orthop Unfall; 2010 Dec;148(6):709-15
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  • [Transliterated title] Enchondrome des Handskeletts - Therapeutisches Vorgehen und funktionelle Langzeitergebnisse.
  • BACKGROUND: An enchondroma is with up to 90% the most common benign tumour of the hand.
  • CONCLUSION: Standard treatment should be the accurate extirpation of the tumour and subsequent filling of the defect with cancellous bone.
  • [MeSH-major] Bone Neoplasms / epidemiology. Bone Neoplasms / surgery. Bone Transplantation / statistics & numerical data. Chondroma / epidemiology. Chondroma / surgery. Hand / surgery

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20213603.001).
  • [ISSN] 1864-6743
  • [Journal-full-title] Zeitschrift für Orthopädie und Unfallchirurgie
  • [ISO-abbreviation] Z Orthop Unfall
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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76. Tan GC, Shiran MS, Swaminathan M, Phang KS, Rohaizak M: Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. Asian J Surg; 2007 Oct;30(4):286-9
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  • Parathyroid carcinoma is an indolent tumour with rather low malignant potential.
  • Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection.
  • Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase.
  • We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.

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  • (PMID = 17962134.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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77. Chaabouni S, Ayadi L, Kallel R, Khabir A, Chaari C, Abbes K, Makni S, Sellami-Boudawara T: Glomus tumour of uncertain malignant potential. Pathologica; 2008 Dec;100(6):492-3
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  • [Title] Glomus tumour of uncertain malignant potential.
  • Macroscopically, the tumour measured 6 x 5 x 5 cm and was well circumscribed.
  • The tumour was characterised by superficial location, large size and focal marked atypia.
  • In addition, areas of benign glomus tumour (GT) were identified.
  • The findings appear to be consistent with the diagnosis of GT of uncertain malignant potential.
  • [MeSH-major] Bone Neoplasms / pathology. Glomus Tumor / pathology. Patella / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Lymphangioma, Cystic / diagnosis. Male. Prognosis

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  • (PMID = 19475896.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Shapeero LG, De Visschere PJ, Verstraete KL, Poffyn B, Forsyth R, Sys G, Uyttendaele D: Post-treatment complications of soft tissue tumours. Eur J Radiol; 2009 Feb;69(2):209-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-treatment complications of soft tissue tumours.
  • PURPOSE: To identify local and distant complications of patients with soft tissue tumours and evaluate their relationships to types of therapy.
  • METHODS AND MATERIALS: Fifty-one patients (29 males and 22 females, ages 14-80 years) with 34 malignant and 17 benign soft tissue tumours were evaluated for local and distant complications after resection or amputation only (26 patients) or after the addition of radiotherapy (25 patients: 17 patients had external beam therapy, 7 patients had external beam therapy and brachytherapy, and one patient had extracorporeal irradiation and reimplantation).
  • Duration of follow-up averaged 3.75 years for malignant tumours and 2.79 years for benign tumours.
  • Follow-up studies included radiography, T1- and T2-weighted magnetic resonance (MR) imaging, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), computed tomography for thoracic and abdominal metastases, and 3-phase technetium-99m-labeled-methylene-diphosphonate scintigraphy for bone metastases.
  • RESULTS: Recurrent tumours were 2.2 times more frequent in patients who had undergone their initial resection at an outside hospital as compared with those first treated at the university hospital.
  • Metastases from soft tissue sarcomas, most commonly to lung (nine patients) and to bone and muscle (five patients), showed no specific relationship to type of therapy.
  • DCE-MRI differentiated rapidly enhancing soft tissue recurrences (11 patients) and residual tumours (6 patients) from slowly enhancing muscle inflammation, and non-enhancing fibrosis and seromas that usually did not enhance.
  • Except for one patient with aggressive fibromatosis, bone and nerve complications occurred in patients with soft tissue malignancy.
  • Six patients sustained fractures in irradiated osteoporotic bone of the lower extremity, and one patient had a vertebral fracture in radiographically normal but irradiated bone.
  • In nerve entrapment, DCE-MRI demonstrated the rapidly enhancing recurrent tumour or non-enhancing fibrosis surrounding the slowly enhancing nerve.
  • CONCLUSION: This study suggests a possible relationship between types of treatment of soft tissue tumours and subsequent complications.
  • Incomplete or difficult surgery resulted in residual or recurrent tumours and heterotopic ossification.
  • Diligent follow-up of patients with soft tissue tumours with recognition of these complications and their differentiation from recurrent or residual tumour can help guide clinical care and may negate the need for surgery when benign disease is defined.
  • [MeSH-major] Postoperative Complications / diagnosis. Postoperative Complications / etiology. Radiation Injuries / diagnosis. Radiation Injuries / etiology. Radiotherapy, Conformal / adverse effects. Soft Tissue Neoplasms / complications. Soft Tissue Neoplasms / therapy

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  • (PMID = 19101106.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Ireland
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79. Carrasco-Moro R, García-Navarrete E, Navas-García M, Llano MA, Sola RG: [Cavernous haemangioma of the skull]. Neurocirugia (Astur); 2009 Dec;20(6):559-62
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  • INTRODUCTION: Cavernous haemangiomas are benign tumours that rarely affect the skull.
  • A correct suspicion diagnosis is seldom obtained when typical radiological signs are lacking.
  • In this way a definite diagnosis is only obtained after a surgical procedure in most cases.
  • Skull CT showed an osteolytic lesion located within the right frontal bone.
  • On suspicion of a metastatic origin of the lesion, a systemic research for a primary tumour was performed without significative findings.
  • Microscopically, the lesion proved to be a cavernous haemangioma of the frontal bone.
  • CONCLUSION: Despite their low frequency, cavernous haemangiomas must be included in the differential diagnosis of slow-growing osteolytic lesions located within the skull.
  • The elective treatment of this tumours includes a complete resection by craniectomy, with safe bony margins.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / pathology. Skull / pathology

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  • (PMID = 19967322.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Eyden B: The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions. J Submicrosc Cytol Pathol; 2005 Nov;37(3-4):231-96
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  • [Title] The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions.
  • This paper describes the ultrastructure of the commoner myofibroblastic tumours and tumour-like lesions.
  • The objective is to complement mainstream pathology texts, which have concentrated on the clinical and light microscopy features of these lesions and which have arguably but understandably somewhat neglected electron microscopy as an ancillary diagnostic tool and a technique for investigating tumour cell biology.
  • Ultrastructural features are described of nodular fasciitis, the myofibromatoses (including Dupuytren's disease), inflammatory myofibroblastic tumour, post-operative spindle cell nodule, fibroma of tendon sheath, fibrous pseudotumour, benign fibrous histiocytoma, atypical fibroxanthoma, dermatofibrosarcoma protuberans, myofibrosarcoma (myofibroblastic sarcoma), malignant fibrous histiocytoma (pleomorphic myofibrosarcoma), epithelioid sarcoma and spindle-cell carcinoma.
  • The fibronexus is emphasised as an important marker for the most confident diagnosis of myofibrosarcoma.
  • Myofibroblastoma and angiomyofibroblastoma are examples of tumours argued on the basis of ultrastructural findings (sometimes in combination with desmin staining) to be primitively differentiated smooth-muscle cell rather than myofibroblastic proliferations.
  • [MeSH-major] Bone Neoplasms / ultrastructure. Fibroblasts / ultrastructure. Neoplasms, Muscle Tissue / ultrastructure. Soft Tissue Neoplasms / ultrastructure

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  • (PMID = 16612972.001).
  • [ISSN] 1122-9497
  • [Journal-full-title] Journal of submicroscopic cytology and pathology
  • [ISO-abbreviation] J. Submicrosc. Cytol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 344
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81. Torres-Lagares D, Infante-Cossío P, Hernández-Guisado JM, Gutiérrez-Pérez JL: Mandibular ameloblastoma. A review of the literature and presentation of six cases. Med Oral Patol Oral Cir Bucal; 2005 May-Jul;10(3):231-8
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  • Ameloblastoma is a benign odontogenic tumour of epithelial origin without induction in the connective tissue.
  • In treating this type of tumour, it is important to assess the clinical type (solid, multicystic, unicystic, peripheral), localisation, and size of the tumour as well as age of the patient.
  • We present data on clinical appearance, histological characteristics, and therapeutic approach that was used, which included excision of the lesion, perilesional drilling of the bone, or block resection, according to the type of ameloblastoma.

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  • (PMID = 15876966.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 33
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82. Mohseny AB, Szuhai K, Romeo S, Buddingh EP, Briaire-de Bruijn I, de Jong D, van Pel M, Cleton-Jansen AM, Hogendoorn PC: Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. J Pathol; 2009 Nov;219(3):294-305
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  • It lacks a benign precursor lesion and reports on associations with hereditary predisposition or germline mutations are uncommon, despite the early age of onset.
  • Moreover, occasional reports in patients mention osteosarcoma formation following bone marrow transplantation for an unrelated malignancy.
  • Our findings suggest a possible hazard for the clinical use of MSCs; however, they also offer new opportunities to study early genetic events in osteosarcoma genesis and, more importantly, to modulate these events and record the effect on tumour progression.
  • [MeSH-major] Bone Neoplasms / pathology. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Mesenchymal Stromal Cells / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Aneuploidy. Animals. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Differentiation. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Disease Models, Animal. Humans. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Nude. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasm Transplantation. Phenotype. Survival Analysis. Treatment Outcome. Tumor Cells, Cultured

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  • (PMID = 19718709.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins
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83. Chand K, Bhardwaj RK, Rappai TJ: Study of 7 Cases of Giant Cell Tumor of Soft Tissue. Med J Armed Forces India; 2006 Apr;62(2):138-40
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  • [Title] Study of 7 Cases of Giant Cell Tumor of Soft Tissue.
  • BACKGROUND: Primary giant cell tumour of soft tissues is a distinct but uncommon group of neoplasms morphologically identical to osseous giant cell tumor.
  • METHODS: 7 patients with painless growing soft tissue mass, having no attachment to underlying bone, were identified in a four years retrospective study from two zonal hospitals of armed forces.
  • Histologic transition between benign and malignant lesion was present in only one of the 7 patients that recurred after three months of surgery for which she had to be operated again.
  • CONCLUSION: Primary giant cell tumour of soft tissues usually present as a painless mass and needs to be differentiated from other giant cell rich soft tissue tumors.
  • Benign clinical course is expected if the lesion is excised adequately.

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  • (PMID = 27407881.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921971
  • [Keywords] NOTNLM ; Giant cell tumour of bone / Giant cell tumour of soft tissue / Malignant fibrous histiocytoma
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84. Schindler OS, Cannon SR, Briggs TW, Blunn GW: Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours. J Orthop Surg (Hong Kong); 2008 Apr;16(1):66-74
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  • [Title] Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.
  • PURPOSE: To report the use of a composite ceramic bone graft substitute containing calcium sulphate and hydroxyapatite (HA) in the treatment of large expansive osteolytic benign bone tumours.
  • METHODS: 4 women and 9 men aged 8 to 49 (mean, 22) years with aneurysmal bone cysts (n=6) or giant cell tumours (n=7) in the epi- or meta-physeal areas of the lower limbs underwent curettage, phenolisation, and filling with bone graft substitute containing calcium sulphate and HA.
  • The mean tumour size was 38.5 (range, 18-65) ml.
  • Range of movement, Musculoskeletal Tumor Society Rating Score (MTSRS), and haematological and blood biochemical parameters were measured.
  • RESULTS: Two patients had recurrence at 7 and 9 months, both progressed to grade-III giant cell tumours.
  • CONCLUSION: Composite bioceramic osteoconductive grafts, which combine porous HA with calcium sulphate, provide a framework for human osteogenesis and avoid donor-site morbidity (autologous bone graft harvesting).
  • Tumour recurrence remains a major concern especially in young patients, as revision invariably requires removal of additional bone, potentially compromising joint integrity.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Bone Substitutes / therapeutic use. Ceramics / therapeutic use. Durapatite / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Female. Femoral Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Tibia / surgery

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  • (PMID = 18453663.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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85. Sakai H, Minemura T, Ito N, Miyazawa H, Kurashina K: Isolated osteochondroma near the mandibular angle. Int J Oral Maxillofac Surg; 2007 Mar;36(3):274-5
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  • A benign tumour of osseous and cartilaginous origins, osteochondroma generally develops in osseous tissue and is frequently found near the end of long bones.
  • This is a report on a rare case of osteochondroma in soft tissue near the mandibular angle without pedicle to the bone.

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  • (PMID = 17052896.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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86. Araki M, Matsumoto K, Matsumoto N, Honda K, Ohki H, Komiyama K: Unusual radiographic appearance of ossifying fibroma in the left mandibular angle. Dentomaxillofac Radiol; 2010 Jul;39(5):314-9
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  • Radiographically, the lesion had some features of a benign tumour, such as an odontogenic myxoma.
  • However, the deep invaginations towards the interalveolar septa suggested a simple bone cyst, whereas the irregular margin and lack of expansion or mandibular canal displacement were consistent with a malignant lesion.
  • [MeSH-minor] Adult. Biopsy. Collagen. Diagnosis, Differential. Female. Humans. Jaw Cysts / radiography. Molar / radiography. Molar, Third / radiography. Odontogenic Tumors / radiography. Osteoblasts / pathology. Tomography, X-Ray Computed. Tooth Apex / radiography

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  • (PMID = 20587656.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Other-IDs] NLM/ PMC3520244
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87. Reize F, Buess E: Humeral osteochondroma causing a subscapularis tear: a rare source of shoulder dysfunction. Arch Orthop Trauma Surg; 2007 Jan;127(1):67-70
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  • The proximal humerus is a well-known site of predilection for the solitary osteochondroma-the most common benign bone tumor.
  • The patient was successfully treated by open resection of the tumor and reattachment of the tendon with suture anchors.
  • [MeSH-major] Bone Neoplasms / complications. Humerus. Osteochondroma / complications. Rotator Cuff / injuries

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  • (PMID = 16927096.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Moriceau G, Ory B, Gobin B, Verrecchia F, Gouin F, Blanchard F, Redini F, Heymann D: Therapeutic approach of primary bone tumours by bisphosphonates. Curr Pharm Des; 2010;16(27):2981-7
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  • [Title] Therapeutic approach of primary bone tumours by bisphosphonates.
  • Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant) including mainly osteosarcoma and other sarcomas.ii)and giant cell tumour and bone metastases originate from others cancer (Breast, prostate, kidney cancer, etc).
  • These tumours are able to destroy or/and induce a new calcified matrix.
  • However, the first step of bone tumour development is associated with an induction of bone resorption and the establishment of a vicious cycle between the osteoclasts and the tumour growth.
  • Indeed, bone resorption contributes to the pathogenesis of bone tumour by the release of cytokines (IL6, TNFα) which govern the bone tumour's development and which are trapped into the bone matrix.
  • Bisphosphonates (BPs) are chemical compounds of P-C-P structure with a high affinity for bone hydroxyapatite crystals.
  • Thus, they have been used as a carrier for radio nucleotides to develop novel approaches of bone imaging.
  • BPs exert also indirect anti-tumour activities in vivo.
  • Indeed, BPs directly interfere with the bone microenvironment and target osteoclasts, endothelial cells and immune cells (tumour-associated macrophages, γ9δ2 T cells).
  • BPs induce tumour cell death in vitro and same activity is suspected in vivo.
  • The present review summarizes the mechanisms of actions of BPs as well as their clinical interests in bone primary tumours.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Bone Neoplasms / drug therapy. Diphosphonates / pharmacology. Diphosphonates / therapeutic use. Drug Design
  • [MeSH-minor] Animals. Bone Density Conservation Agents / pharmacology. Bone Density Conservation Agents / therapeutic use. Chondrosarcoma / drug therapy. Giant Cell Tumor of Bone / drug therapy. Humans. Osteosarcoma / drug therapy


89. Dalghous A, Alkhabuli JO: Cemento-ossifying fibroma occurring in an elderly patient. A case report and a review of literature. Libyan J Med; 2007 Jun 01;2(2):95-8
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  • Cemento-ossifying fibromas (COF) are benign lesions affecting the jaws and other craniofacial bones.
  • The tumour may grow quite extensively, thus the term aggressive is some times applied.
  • Their clinical, radiographical and histopathological features and those of fibro-osseous lesions are overlapping and may cause confusion in classification, diagnosis, and treatment.
  • The histopathology is composed of fibrous tissues with calcified structures resembling bone or cementum.

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  • (PMID = 21503260.001).
  • [ISSN] 1993-2820
  • [Journal-full-title] The Libyan journal of medicine
  • [ISO-abbreviation] Libyan J Med
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3078280
  • [Keywords] NOTNLM ; Cemento-ossifying fibroma in elderly patient / Mandible / Non-aggressive cemento-ossifying fibroma
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90. Karwacki MW, Woźniak W: [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 2):923-48
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  • [Title] [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia].
  • Both are autosomal dominant disorders with 100% penetration, variable expression and 50% rate of new (de novo) mutations.
  • The protein products of both, NF1 andNF2 genes are best known and the genes serve as tumour suppressors.
  • Mutations result in a predisposition to develop a variety of tumours of the central and peripheral nervous systems, as well as other malignancies.
  • Nf-2 is a multisystem genetic disorder associated with bilateral vestibular schwannomas, spinal cord schwannomas, meningiomas, gliomas, and juvenile cataracts with a paucity of cutaneous features, which are seen more consistently in Nf-1.
  • In contrast to Nf-1, Nf-2 is associated with significant morbidity and decreased life span and a higher incidence of CNS tumours.
  • Optic gliomas and both malignant and benign peripheral nerve sheet tumours are the most common malignancies arising in Nf-1 patients.
  • Bone dysplasia results in scoliosis.
  • [MeSH-major] Genes, Neurofibromatosis 1. Genes, Neurofibromatosis 2. Neurofibromatoses / diagnosis. Neurofibromatoses / genetics
  • [MeSH-minor] Comorbidity. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / epidemiology. Cranial Nerve Neoplasms / genetics. Genetic Predisposition to Disease. Humans. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / genetics. Optic Nerve Diseases / diagnosis. Optic Nerve Diseases / genetics. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Scoliosis / diagnosis. Scoliosis / epidemiology. Scoliosis / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / genetics. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / genetics. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / epidemiology. Spinal Cord Neoplasms / genetics


91. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Western Australia / epidemiology

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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92. Arrabal-Polo MA, Arias-Santiago SA, Aneiros-Fernandez J, Burkhardt-Perez P, Arrabal-Martin M, Naranjo-Sintes R: Cutaneous metastases in renal cell carcinoma: a case report. Cases J; 2009;2:7948
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  • Renal cell carcinoma is the most common form of malignant renal tumour and is extremely lethal.
  • About 25% of the patients develop metastasis at the time of diagnosis, and in many cases during the course of the disease, affecting the lung, lymphatic ganglions, liver, and bone, with skin metastases being quite rare.A 73-year-old patient, who had undergone surgery for adenocarcinoma in the left kidney 10 years previously, visited the dermatological service due to the appearance of recent, rapidly-developing lesion at the back of his neck.
  • Urologist should pay attention to cutaneous lesion appearing in these patients as in many times they look like benign lesion.

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  • (PMID = 19918439.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769389
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93. Wicart P, Seringe R: [Protective limp]. Arch Pediatr; 2008 Mar;15(3):340-8
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  • The diagnosis of acute transient synovitis (irritable hip) should only be made after excluding other conditions including benign bone tumours (such as ostioid osteoma), malignant tumours, inflammatory monoarthritis, primary osteochondritis of the hip, trauma with or without fracture, apophysitis, leukemia, etc.
  • The diagnosis of acute transient synovitis should be questioned if the condition persists for more than seven days.
  • After the age of nine years, the diagnosis that is important not to miss is proximal femoral epiphysiolysis, because this condition can have serious implications for the future function of the hip.
  • Finally, a psychogenic aetiology, tendinitis, or sprain should not be considered in children, and they risk delaying the diagnosis of a potentially serious condition.

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  • (PMID = 18314314.001).
  • [ISSN] 0929-693X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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94. van de Luijtgaarden AC, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT: Metastatic potential of an aneurysmal bone cyst. Virchows Arch; 2009 Nov;455(5):455-9
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  • [Title] Metastatic potential of an aneurysmal bone cyst.
  • Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa.
  • Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient.
  • Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Bone Neoplasms / pathology. Neoplasms, Second Primary / pathology. Osteosarcoma / pathology. Proto-Oncogene Proteins / genetics. Ubiquitin Thiolesterase / genetics

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  • (PMID = 19838726.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Proto-Oncogene Proteins; 2S9ZZM9Q9V / Bevacizumab; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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95. Montañez-Heredia E, Serrano-Montilla J, Merino-Ruiz ML, Amores-Ramírez F, Villalobos-Martín J: Osteoid osteoma: CT-guided radiofrequency ablation. Acta Orthop Belg; 2009 Feb;75(1):75-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumour; its main symptom is pain, which is sometimes resistant to analgesic or anti-inflammatory medication.
  • [MeSH-major] Bone Neoplasms / surgery. Osteoma, Osteoid / surgery

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  • (PMID = 19358403.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
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96. Ben hadj Hamida F, Jlaiel R, Ben Rayana N, Mahjoub H, Mellouli T, Ghorbel M, Krifa F: [Craniofacial fibrous dysplasia: a case report]. J Fr Ophtalmol; 2005 Oct;28(8):e6
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  • Fibrous dysplasia is classified among benign bone tumors.
  • It is a bone development anomaly characterized by hamartoma proliferation of fibrous tissue within the medullary bone, with secondary bony metaplasia, producing immature, newly formed and weakly calcified bone, without maturation of the osteoblast.
  • Its diagnosis is not always straightforward because the functional symptomology is often absent or not specific.
  • Medical imagery is necessary and in difficult cases a bone biopsy.
  • [MeSH-major] Facial Bones. Fibrous Dysplasia, Polyostotic / diagnosis. Skull

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  • (PMID = 16249758.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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97. Colagrande S, Carbone SF, Carusi LM, Cova M, Villari N: Magnetic resonance diffusion-weighted imaging: extraneurological applications. Radiol Med; 2006 Apr;111(3):392-419
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  • With regard to the latter, although there are differences between benign forms [focal nodular hyperplasia (FNH), adenoma] and malignant forms [metastasis, hepatocellular carcinoma (HCC)] in their apparent diffusion coefficient (ADC) in the average values for histological type, there is a significant overlap in values when lesions are assessed individually, with the consequent problem of their correct identification.
  • Here it is possible to differentiate mucin-producing tumours of the pancreas from pseudocystic forms on the basis of ADC values even though the limited spatial resolution of Dw imaging does not enable the identification of small lesions.
  • Dw imaging may be applied to the study of the kidney to differentiate hydronephrosis from pyonephrosis and with regard to tumours, solid from pseudocystic forms.
  • Attempts have therefore been made to use Dw imaging in the characterization of soft-tissue tumours although the findings so far have been disputed.
  • Greater agreement has been found regarding sensitivity of the technique in assessing response of these tumours to chemotherapy: tumour necrosis is thought to increase ADC whereas the persistence of vital neoplastic tissue tends to lower it.
  • Dw imaging has also been used in the assessment of bone marrow cellularity: areas of tightly packed cells show a higher ADC value than hypocellular areas.
  • In particular, no significant difference in ADC is noted between normal hypercellular bone marrow and hypercellular bone marrow secondary to lymphomatous infiltration whereas this difference is significant between hypocellular, normocellular and haematopoietic hypercellular bone marrow.
  • [MeSH-minor] Bone Diseases / diagnosis. Echo-Planar Imaging. Humans. Kidney Diseases / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis. Pancreatic Diseases / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16683086.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 63
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98. Singh J, James SL, Kroon HM, Woertler K, Anderson SE, Jundt G, Davies AM: Tumour and tumour-like lesions of the patella--a multicentre experience. Eur Radiol; 2009 Mar;19(3):701-12
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  • [Title] Tumour and tumour-like lesions of the patella--a multicentre experience.
  • Fifty-nine cases of lesions presenting in the patella were identified after review of the databases of four European bone tumour registries.
  • Of the 59 cases, 46% were non neoplastic, 39% were benign and 15% were malignant.
  • The commonest benign neoplasm was giant cell tumour (GCT) (11 cases).
  • Younger patients were more likely to have a benign neoplasm.
  • Lesions in patients less than 40 years of age included giant cell tumour, chondroblastoma, aneurysmal bone cyst (ABC), osteomyelitis, osteoid osteoma and solitary bone cyst.
  • In patients older than 40 years, the following were common lesions: intra-osseous gout, metastasis and intra-osseous ganglion.
  • Expansion of the patella with thinning of cortex was seen more commonly in GCT and brown tumour in hyperparathyroidism.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumors / pathology. Patella / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Diagnosis, Differential. Female. Humans. Male. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Radiology / methods

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  • [ErratumIn] Eur Radiol. 2010 Mar;20(3):763. Jundt, G [added]
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  • (PMID = 18815789.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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99. Finstein JL, Hosalkar HS, Ogilvie CM, Lackman RD: Case reports: an unusual complication of radiofrequency ablation treatment of osteoid osteoma. Clin Orthop Relat Res; 2006 Jul;448:248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Osteoma, Osteoid / surgery. Skin / pathology. Skin Diseases / etiology. Tibia

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  • [CommentIn] Clin Orthop Relat Res. 2006 Oct;451:290-1; author reply 291-2 [16906101.001]
  • [CommentIn] Clin Orthop Relat Res. 2007 Jul;460:285; author reply 285-6 [17534193.001]
  • (PMID = 16826123.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Sinha R, Roy Chowdhury SK, Chattopadhyay PK, Rajkumar K: Low-grade osteosarcoma of the mandible. J Maxillofac Oral Surg; 2010 Jun;9(2):186-90
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  • Osteosarcoma (OS), a rare malignant bone tumour arising from primitive bone forming mesenchyme, most often arises in the metaphyses of long bones of the extremities.
  • Bone or osteoid formation within the tumour is characteristic of an osteosarcoma.
  • In general, OS of the jaw is a high-grade lesion.
  • Because of its rarity and well differentiation, Low-grade OS is usually misdiagnosed as a benign lesion.
  • The clinical and radiographic presentation does not correlate well with the subtle histology picture of a low-grade osteosarcoma which makes the diagnosis difficult.

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  • (PMID = 22190784.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244089
  • [Keywords] NOTNLM ; Craniofacial osteosarcoma / Low-grade osteosarcoma
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