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6. Rodríguez Paramás A, Lendoiro Otero C, González García JA, Souviron Encabo R, Scola Yurrita B: [Temporal bone chondroblastoma. A clinical case and literature review]. Acta Otorrinolaringol Esp; 2006 Aug-Sep;57(7):336-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Temporal bone chondroblastoma. A clinical case and literature review].
  • [Transliterated title] Condroblastoma de hueso temporal. Caso clínico y revisión de la literatura.
  • After radiologic diagnosis, intraoperatory biopsy and surgical removal, the anatomopathological result confirmed the histology of chondroblatoma, with a satisfactory postoperative evolution.
  • The chondroblastoma is a benign bone tumor typically located in the epiphysis of long bones and the temporal bone is an excepcional location as we have verified through a literature review.
  • [MeSH-major] Chondroblastoma. Skull Neoplasms. Temporal Bone

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  • (PMID = 17036998.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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7. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Liang X, Jiang D, Ni W: [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):785-8
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  • [Title] [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor].
  • OBJECTIVE: To observe the clinical effect and safety of the nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite in repairing the bone defects due to benign bone tumors.
  • METHODS: From January 2003 to May 2005, 38 patients (21 males, 16 females; age, 19-58 years, averaged 38.5 years) with the bone defects due to benign bone tumors were treated with the n-HA/PA66 grains.
  • Among the 37 patients, 11 had fibrous dysplasia, 14 had bone cyst, 10 had giant cell tumor of the bone (Grade I ), and 2 had enchondroma.
  • The tumors ranged in size from 1.0 cm x 0.7 cm x 0.4 cm to 10.0 cm x 4.0 cm x 3.0 cm, with the location of the proximal femur in 12 patients, the distal femur in 7, the proximal tibia in 9, the proximal humerus in 5, the phalanges of the finger in 2, the metacarpal bone in 1, and the calcaneus in 1.
  • All the benign bone tumors underwent the curettage treatment, and then the tumor cavities were filled up with the n-HA/PA66 grains.
  • The incision healing, local inflammatory reaction, rejection, toxic reaction, tumor cavity healing, and function recovery of the limbs were all observed after operation.
  • At 3 to 5.5 months(mean 4 months) after operation, osteogenesis was found in the space filled with the n-HA/PA66 grains.
  • CONCLUSION: The n-HA/PA66 grains have great biological safety, good biocompatibility, and good bone conduction, which are good materials for the bone repair and reconstruction, and can be safely, and effectively used for repairing the bone defects due to benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes. Hydroxyapatites. Nylons
  • [MeSH-minor] Adult. Biocompatible Materials. Bone Cysts / surgery. Female. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Nanostructures. Reconstructive Surgical Procedures / methods. Treatment Outcome. Wound Healing. Young Adult

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  • (PMID = 17882867.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / Nylons
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9. Tamai N, Myoui A, Kudawara I, Ueda T, Yoshikawa H: Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor. J Orthop Sci; 2010 Jul;15(4):560-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor.
  • BACKGROUND: Large bone defects remaining after curettage of benign bone tumors should be filled with a substitute to restore mechanical strength.
  • In 2000, we developed a fully interconnected porous calcium hydroxyapatite ceramic (IPCHA, NEOBONE) and have utilized it as a bone substitute.
  • The large interconnecting channels (average diameter 40 microm) permit easy penetration of tissue into the deep pores, so IP-CHA can itself induce local bone repair processes.
  • The purpose of this study was to evaluate the clinical outcomes with the use of IP-CHA as bone substitute after curettage of benign bone tumors.
  • METHODS: We reviewed the results of 71 patients with benign bone tumors sequentially treated by curettage followed by implantation of IP-CHA between 2000 and 2006.
  • Radiographic findings were classified into five stages: stage 0, no change; stage 1, slight bone formation; stage 2, moderate bone formation; stage 3, consolidation; stage 4, absorption.
  • However, there were 10 local recurrences, which is similar to the recurrence rate for such tumors treated with or without implantation of CHAs and reflects the biological nature of each tumor.
  • CONCLUSIONS: In this study, we utilized IP-CHA as a bone substitute after curettage of benign bone tumors and demonstrated its usefulness in the clinical situation.
  • IP-CHA comparatively exhibited excellent bone formation at an early stage although the problem of recurrence of the tumor remained.
  • We conclude that IP-CHA is a useful bone substitute for the treatment of benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics / therapeutic use. Durapatite / therapeutic use. Osteogenesis
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Substitutes / therapeutic use. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20721726.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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10. Panagopoulos I, Mertens F, Löfvenberg R, Mandahl N: Fusion of the COL1A1 and USP6 genes in a benign bone tumor. Cancer Genet Cytogenet; 2008 Jan 1;180(1):70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fusion of the COL1A1 and USP6 genes in a benign bone tumor.
  • Aneurysmal bone cyst (ABC) is a benign intraskeletal cyst that often expands rapidly and shows a strong tendency to recur.
  • Here we report a second case of a bone tumor carrying a t(17;17) resulting in a COL1A1-USP6 chimeric gene.
  • [MeSH-major] Bone Neoplasms / genetics. Collagen Type I / genetics. Gene Fusion. Proto-Oncogene Proteins / genetics. Tibia. Translocation, Genetic. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Adolescent. Chromosomes, Human, Pair 17. Humans. Male. Neoplasm Regression, Spontaneous

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  • (PMID = 18068538.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Proto-Oncogene Proteins; 0 / collagen type I, alpha 1 chain; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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11. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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12. Keser S, Bayar A: Osteochondroma of the talar neck: a rare cause of callosity of the foot dorsum. J Am Podiatr Med Assoc; 2005 May-Jun;95(3):295-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor.
  • [MeSH-major] Bone Neoplasms / complications. Callosities / etiology. Osteochondroma / complications. Talus

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  • (PMID = 15901820.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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1
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4. Blazick E, Keeling WB, Armstrong P, Letson D, Back M: Pseudoaneurysm of the superficial femoral artery associated with osteochondroma--a case report. Vasc Endovascular Surg; 2005 Jul-Aug;39(4):355-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas, the most common benign bone tumor, often go undetected and seldom cause significant clinical sequelae.

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  • (PMID = 16079946.001).
  • [ISSN] 1538-5744
  • [Journal-full-title] Vascular and endovascular surgery
  • [ISO-abbreviation] Vasc Endovascular Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Teoh KH, Shortt N, Wilkinson G, Salter DM, Robb JE, Porter DE: Bizarre parosteal osteochondromatous proliferation of the metatarsal: a pediatric case report and archival review. J Foot Ankle Surg; 2009 Nov-Dec;48(6):690.e7-690.e11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bizarre parosteal osteochondromatous proliferations (BPOP), also known as Nora's lesions, are rare tumors occurring most commonly in the hands and feet.
  • They are benign and rarely exhibit radiological evidence of cortical invasion.
  • We also review the BPOP cases in our regional benign bone tumor database.
  • [MeSH-major] Metatarsus. Osteochondromatosis / diagnosis
  • [MeSH-minor] Biopsy. Cell Proliferation. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Orthopedic Procedures / methods

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  • (PMID = 19857830.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Finstein JL, Hosalkar HS, Ogilvie CM, Lackman RD: Case reports: an unusual complication of radiofrequency ablation treatment of osteoid osteoma. Clin Orthop Relat Res; 2006 Jul;448:248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Osteoma, Osteoid / surgery. Skin / pathology. Skin Diseases / etiology. Tibia

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  • [CommentIn] Clin Orthop Relat Res. 2006 Oct;451:290-1; author reply 291-2 [16906101.001]
  • [CommentIn] Clin Orthop Relat Res. 2007 Jul;460:285; author reply 285-6 [17534193.001]
  • (PMID = 16826123.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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18. Turcotte RE: Giant cell tumor of bone. Orthop Clin North Am; 2006 Jan;37(1):35-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of bone.
  • Giant cell tumor is a common benign bone tumor that possesses specific features including location at the end of long bone, a strong tendency toward local recurrence, and the rare capacity to metastasize to the lungs.
  • Preferred treatment usually consists of extensive curettage and filling of the cavity with bone graft or cement.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fractures, Spontaneous / pathology. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Bone Transplantation / methods. Combined Modality Therapy. Curettage / methods. Female. Humans. Incidence. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Risk Assessment. Sex Distribution. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16311110.001).
  • [ISSN] 0030-5898
  • [Journal-full-title] The Orthopedic clinics of North America
  • [ISO-abbreviation] Orthop. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 123
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19. Teka A, Admassie D, Schneider J: Osteochondroma of the coccyx: a case report. Ethiop Med J; 2010 Jul;48(3):247-51
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  • Osteochondroma is the most common benign bone tumor.

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  • (PMID = 21073087.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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20. Arkader A, Dormans JP, Gaugler R, Davidson RS: Spontaneous regression of solitary osteochondroma: reconsidering our approach. Clin Orthop Relat Res; 2007 Jul;460:253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas are the most common benign bone tumor; nonetheless, the natural history is poorly understood as a result of the low threshold for resection and the fact that many of these lesions are asymptomatic and therefore never diagnosed.
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Remission, Spontaneous

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  • (PMID = 17620816.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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21. Guo S, Feng W, Jia Y: [Lyophilized small-segment allogeneic bone in repairing bone defect due to benign bone tumor and tumor-like lesions after resection and curettage]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):789-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lyophilized small-segment allogeneic bone in repairing bone defect due to benign bone tumor and tumor-like lesions after resection and curettage].
  • OBJECTIVE: To investigate the clinical application and complication of the lyophilized small-segment allogeneic bone used in repairing bone defects caused by benign bone tumor and tumor-like lesions after resection and curettage.
  • 8 years), who had bone defects caused by benign bone tumors and tumor-like lesions after surgical resection and curettage, were treated by the lyophilized small-segment allogeneic bones.
  • The cavities left by the tumor curettage ranged in size from 1.0 cm x 0.8 cm to 10.0 cm x 2.0 cm, and the bone defects were about 1.0 to 3.5 cm in diameter after the localized resection of the bones.
  • According to the bone defect degrees, the autogenous nonvascular iliac bone and the bone allograft (0.5-30.0 g) were implanted, followed by the drainage for 2-3 days and the use of antibiotics to prevent infection.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone union.
  • RESULTS: There was no significant difference in the allergic reactions, such as postoperative temperature, drained amount, and body swelling, between this kind of transplantation and the autogenous bone transplantation.
  • The follow-up for 6-60 months (average, 38 months) revealed that all the patients had the allograft unions of the bones within 6-18 months after the transplantation, and only 6 patients had recurrence of the tumor (3.0%).
  • CONCLUSION: The lyophilized small-segment allogeneic bone has a good compatibility and osteogenesis, when it is used in repairing bone defects caused by benign bone tumor and tumor-like lesions after resection and curettage.
  • So, this kind of bone is a good, convenient and safe material for the bone transplantation.
  • The important factors affecting the allograft union are as follows: the mechanical stability in the recipient region, local blood supply, and management of the bone cavity left by resection and curettage of the bone tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Ilium / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Cysts / radiography. Bone Cysts / surgery. Child. Child, Preschool. Curettage. Female. Follow-Up Studies. Freeze Drying. Humans. Male. Middle Aged. Postoperative Complications / surgery. Transplantation, Autologous. Transplantation, Homologous. Wound Healing. Young Adult

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  • (PMID = 17882868.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Stănescu L, Popescu CF, Niculescu CE, Dumitrescu D, Mogoantă SS, Georgescu I: Subungual exostosis of the big toe. Rom J Morphol Embryol; 2009;50(3):501-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The subungual exostosis is a benign bone tumor on the distal phalanx of a digit, beneath or adjacent to the nail, often bringing in discussion many differential diagnosis.
  • In the present, the radiological findings of the affected finger and the histopathological ones from the fragment excised confirmed the diagnosis of subungual exostosis.

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  • (PMID = 19690782.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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23. Myoui A, Yoshikawa H: [Regenerative medicine in bone tumor surgery]. Clin Calcium; 2008 Dec;18(12):1767-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Regenerative medicine in bone tumor surgery].
  • In bone tumor surgery, target of bone tissue engineering technique will be the reconstruction of large bone void after tumor excision.
  • It may be also useful to accelerate the regeneration of processed autologous bone grafts such as irradiated bone.
  • Interconnected porous ceramics bone substitutes have been considered to be useful as a scaffold for bone engineering.
  • We started a clinical trial on bone regeneration to evaluate its safety and efficiency using mesenchymal stem cells derived from autologous bone marrow aspirates and porous hydroxyapatite ceramics as a scaffold.
  • In this study, after osteoblastic differentiation culture for several weeks, cells integrated to porous ceramics are transplanted into the defect after removal of large benign bone tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Regenerative Medicine / methods. Tissue Engineering / methods
  • [MeSH-minor] Bone Regeneration. Bone Substitutes. Bone Transplantation. Cell Differentiation. Cells, Cultured. Humans. Mesenchymal Stem Cell Transplantation. Osteoblasts / cytology. Tissue Scaffolds

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  • (PMID = 19043191.001).
  • [ISSN] 0917-5857
  • [Journal-full-title] Clinical calcium
  • [ISO-abbreviation] Clin Calcium
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 18
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24. Abou-Elhamd KE: Frontal sinus cementifying ossifying fibroma. Saudi Med J; 2005 Mar;26(3):470-2
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  • Cementifying ossifying fibroma is a fibro-osseous lesion which produces cementum.
  • Cementifying ossifying fibroma is a mesodermal, non-odontogenic tumor of ectopic multipotential periodontal membrane blast cells.
  • Although, it is a benign bone tumor, it has an aggressive destructive behavior in patients under 20 years of age with high tendency for recurrence.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibroma, Ossifying / diagnosis. Frontal Sinus

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  • (PMID = 15806222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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25. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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26. Abolghasemian M, Rezaie M, Behgoo A, Shoushtarizadeh T, Ghazavi MT: Exostosis-like intra-articular periosteal osteoblastoma: a rare case. Am J Orthop (Belle Mead NJ); 2010 Jun;39(6):E50-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is a relatively rare benign bone tumor, most often located in the vertebral column or metaphysis of the long bones, particularly the femur and the tibia.
  • Exostosis-like appearance is not common even in periosteal osteoblastoma, a very rare type of this tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Hip Joint / pathology. Osteoblastoma / pathology. Periosteum / pathology

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  • (PMID = 20631934.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ayadi-Kaddour A, Saïji E, Fénniche S, Braham E, Ismail O, Djilani H, El Mezni F: [Costal chondromyxoid fibroma]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Feb;93(1):84-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is a rare benign bone tumor observed in less than 1% of all bone tumors.
  • Pathological diagnosis remains difficult.
  • All bone sites may be involved with a predominance of the metaphysis of long tubular bones, particularly the proximal tibia.
  • The tumor has been rarely reported in ribs.
  • Local resection was performed and the histological examination showed benign chondromyxoid fibroma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Ribs / pathology

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  • (PMID = 17389829.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Reize F, Buess E: Humeral osteochondroma causing a subscapularis tear: a rare source of shoulder dysfunction. Arch Orthop Trauma Surg; 2007 Jan;127(1):67-70
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  • The proximal humerus is a well-known site of predilection for the solitary osteochondroma-the most common benign bone tumor.
  • The patient was successfully treated by open resection of the tumor and reattachment of the tendon with suture anchors.
  • [MeSH-major] Bone Neoplasms / complications. Humerus. Osteochondroma / complications. Rotator Cuff / injuries

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  • (PMID = 16927096.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Kirchhoff C, Buhmann S, Mussack T, Müller-Höcker J, Schmitt-Sody M, Jansson V, Dürr HR: Aggressive scapular chondroblastoma with secondary metastasis--a case report and review of literature. Eur J Med Res; 2006 Mar 27;11(3):128-34
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  • Chondroblastoma is a benign bone tumor, accounting for approximately one percent of all benign bone tumors.
  • Therefore, we report a unique case of chondroblastoma with tumor manifestation in the 7th decade of life, location of the tumor in the scapula and occurrence of metastasis in the soft tissue of the mandible branch.
  • The differential diagnosis is discussed and the current literature concerning malignant transformation of chondroblastoma is reviewed.
  • [MeSH-major] Bone Neoplasms. Chondroblastoma / secondary

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  • (PMID = 16751114.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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30. Lucas DR: Osteoblastoma. Arch Pathol Lab Med; 2010 Oct;134(10):1460-6
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  • Osteoblastoma is a rare benign bone tumor.
  • Although the histologic features in most cases are distinctive, there are various permutations that make the diagnosis challenging.
  • It can mimic a variety of other benign bone tumors, but more importantly, distinguishing it from osteoblastoma-like osteosarcoma can be difficult.
  • [MeSH-major] Bone Neoplasms / pathology. Osteoblastoma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Cartilage, Articular / pathology. Cartilage, Articular / radiography. Diagnosis, Differential. Humans. Male. Osteoblasts / pathology. Osteoblasts / radiography. Osteoclasts / pathology. Osteoclasts / radiography. Tomography, X-Ray Computed

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  • (PMID = 20923301.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Patrício JP, Oliveira P, Fernandes H, Oliveira A, Faria MT, Pérez MB, Pereira J: [Osteoid osteoma]. Acta Med Port; 2009 Sep-Oct;22(5):613-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is the third most common benign bone tumor.
  • The three phase bone scintigraphy revealed a focal uptake in the mid shaft of the left femur, strongly suggestive of osteoid osteoma.
  • This case shows the significant role of bone scintigraphy in the diagnosis of an osteoma osteoid with atipical presentation.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis

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  • (PMID = 19944046.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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32. Azorín D, González-Mediero I, Colmenero I, De Prada I, López-Barea F: Diaphyseal chondroblastoma in a long bone: first report. Skeletal Radiol; 2006 Jan;35(1):49-52
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  • [Title] Diaphyseal chondroblastoma in a long bone: first report.
  • Chondroblastoma is a rare benign bone tumor typically located in the epiphysis.
  • We describe the first case of chondroblastoma arising in the diaphysis of a long bone.

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  • (PMID = 16010594.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Yasuda T, Nishio J, Sumegi J, Kapels KM, Althof PA, Sawyer JR, Reith JD, Bridge JA: Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. Mod Pathol; 2009 Nov;22(11):1499-506
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma.
  • The breakpoint on 6q13 was located within the COL12A1 gene, a collagen gene purportedly involved in another benign bone tumor, subungual exostosis.

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  • (PMID = 19648885.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA036727-249009; United States / NCI NIH HHS / CA / P30 CA036727; United States / NCI NIH HHS / CA / P30 CA036727-249009; United States / NCI NIH HHS / CA / P30 CA36727
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / COL12A1 protein, human; 0 / Collagen Type XII; 9007-34-5 / Collagen
  • [Other-IDs] NLM/ NIHMS124998; NLM/ PMC2784180
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34. Samartzis D, Marco RA: Osteochondroma of the sacrum: a case report and review of the literature. Spine (Phila Pa 1976); 2006 Jun 1;31(13):E425-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY OF BACKGROUND DATA: Osteochondroma is the most common primary benign bone tumor.
  • However, this tumor rarely involves the spine and even more rarely involves the sacrum.
  • The tumor was excised en bloc through a posterior approach.
  • The cavitary defect within the sacrum was reconstructed with crushed cancellous allograft and demineralized bone matrix putty.
  • RESULTS: Histologic studies showed the tumor to be an osteochondroma.
  • CONCLUSIONS: Osteochondroma is a rare primary benign bone tumor that can occur in the sacrum.

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  • (PMID = 16741444.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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35. Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E: Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Ups J Med Sci; 2008;113(2):209-16
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eosinophilic granuloma (EG) is a benign tumor-like condition which is characterized by a clonal proliferation of Langerhans-type histiocytes and defined as a local form of Langerhans cell histiocytosis (LCH).
  • A status of EG in the bone is divided into acute and chronic phases.
  • Radiologically acute phase of EG is difficult to differentiate from a malignant bone tumor such as Ewing's sarcoma or acute osteomyelitis.
  • Chronic phase of EG may mimic a chronic osteomyelitis or a benign bone tumor.
  • These lesions resembled radiologically chronic osteomyelitis (Brodie's abscess) or a benign bone tumor and healed spontaneously after biopsy.
  • It was difficult to differentiate from a malignant tumor such as Ewing's sarcoma, or acute osteomyelitis.
  • Curettage of the affected site and bone grafting is usually accomplished.
  • [MeSH-major] Bone Neoplasms / complications. Eosinophilic Granuloma / etiology. Osteomyelitis / complications. Pelvis

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  • (PMID = 18509815.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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36. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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37. Samdani A, Torre-Healy A, Chou D, Cahill AM, Storm PB: Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J; 2009 Jul;18 Suppl 2:196-200
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  • Osteoblastoma is a rare benign bone tumor that presents with back pain and occurs in the spine approximately 40% of the time.
  • The time from onset of symptoms to diagnosis is typically several months because it is a rare entity and radiographic studies are often negative early in the course of the disease.
  • These highly vascular and locally aggressive tumors require complete and precise resection.
  • He subsequently underwent piecemeal tumor resection and instrumented fusion.

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  • (PMID = 18839223.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2899567
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38. Mortazavi SM, Wenger D, Asadollahi S, Shariat Torbaghan S, Unni KK, Saberi S: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol; 2007 Mar;36(3):259-64
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is an uncommon benign bone tumor most commonly located in the vertebral column or metaphysis of a long bone.
  • Histopathologic evaluation disclosed immature bone and osteoid deposition in a vascularized stroma, associated with numerous osteoblasts and osteoclasts rimming the bony trabeculae.
  • Although extremely unusual, the presence of cartilage does not necessarily exclude the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Knee Joint / pathology. Osteoblastoma / diagnosis. Periosteum / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 16868789.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
  •  go-up   go-down


39. Freschi S, Dodson NB: Osteoid osteoma: an uncommon cause of foot pain. J Am Podiatr Med Assoc; 2007 Sep-Oct;97(5):405-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An osteoid osteoma located in the forefoot can be difficult to diagnose, and the diagnosis is frequently delayed.
  • Although rarely seen in the metatarsal, osteoid osteoma should be included in the differential diagnosis of foot pain.
  • Findings from radiographs, magnetic resonance images, and a detailed clinical history led to the diagnosis of osteoid osteoma of the left second metatarsal.
  • We review osteoid osteoma, including the classic clinical presentation and treatment associated with this benign bone tumor.

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  • (PMID = 17901347.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Kim J, Kumar R, Raymond AK, Ayala AG: Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature. Skeletal Radiol; 2010 Jun;39(6):583-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature.
  • Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone.
  • We describe such a case of chondroblastoma arising in the iliac bone.
  • The radiographs and CT revealed an expansile lytic lesion in the right iliac bone.
  • The histopathology revealed the lesion to be a chondroblastoma with secondary features of aneurysmal bone cyst.
  • An en bloc surgical resection of the tumor was performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / complications. Bone Cysts, Aneurysmal / radiography. Bone Neoplasms / complications. Bone Neoplasms / radiography. Chondroblastoma / complications. Chondroblastoma / radiography. Ilium / radiography. Tomography, X-Ray Computed

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  • (PMID = 19936740.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 12
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41. Yoo WH, Kim JR, Jang KY, Lee SY, Park JH: Rapidly developed huge bursitis associated with scapular osteochondroma of the multiple exostosis: a case report. Rheumatol Int; 2009 Jan;29(3):317-9
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  • Osteochondroma is the most common benign bone tumor and present as multiple masses in the hereditary disorder of multiple hereditary exostosis.

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  • (PMID = 18682954.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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42. Sidani CA, Karam AR, Bruce JH, Sklar E: Osteoblastoma of the frontal sinuses presenting with headache and blurred vision: case report and review of the literature. J Radiol Case Rep; 2010;4(6):1-7

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  • Osteoblastoma is a rare benign bone tumor that usually arises in the vertebral column and long bones of young adults.

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  • (PMID = 22470734.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303412
  • [Keywords] NOTNLM ; Frontal sinus / exophthalmos / osteoblastoma
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43. Nomoto A, Hirakawa M, Yoshimitsu K, Irie H, Tajima T, Nishie A, Ishimgami K, Ushijima Y, Okamoto D, Yamada I, Honda H: [CT-guided radiofrequency ablation for osteoid osteoma]. Fukuoka Igaku Zasshi; 2008 Oct;99(10):214-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Osteoma, Osteoid / surgery

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  • (PMID = 19195219.001).
  • [ISSN] 0016-254X
  • [Journal-full-title] Fukuoka igaku zasshi = Hukuoka acta medica
  • [ISO-abbreviation] Fukuoka Igaku Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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44. Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, Konishi E, Kubo T: Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med; 2008 Apr;22(3):221-4
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  • [Title] Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma.
  • Chondromyxoid fibroma (CMF) is a benign bone tumor.
  • However, it is sometimes difficult to distinguish this tumor from chondrosarcoma.
  • The tumor was diagnosed as CMF by open biopsy.
  • It is important that CMF is correctly distinguished from other tumors because this may be histologically overdiagnosed as chondrosarcoma.
  • Contrast-enhanced MR imaging and thallium-201 scintigraphy may be useful to distinguish CMF from benign bone tumors or chondrosarcoma.
  • [MeSH-minor] Adolescent. Biopsy. Citrates / pharmacokinetics. Contrast Media / pharmacokinetics. Diagnosis, Differential. Diphosphonates / pharmacokinetics. Fibroma / radiography. Fibroma / radionuclide imaging. Fibula / pathology. Gadolinium DTPA / pharmacokinetics. Gallium / pharmacokinetics. Humans. Knee Joint / pathology. Knee Joint / radiography. Knee Joint / radionuclide imaging. Knee Joint / surgery. Magnetic Resonance Imaging. Male. Osteolysis / radiography. Radionuclide Imaging. Radiopharmaceuticals / pharmacokinetics. Technetium Compounds / pharmacokinetics

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  • (PMID = 18498038.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Citrates; 0 / Contrast Media; 0 / Diphosphonates; 0 / Radiopharmaceuticals; 0 / Technetium Compounds; 0 / Thallium Radioisotopes; 27905-02-8 / gallium citrate; 8V3FGC4J77 / technetium Tc 99m diphosphonate; CH46OC8YV4 / Gallium; K2I13DR72L / Gadolinium DTPA
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45. Jonathan A, Rajshekhar V, Chacko G: Chondromyxoid fibroma of the seventh cervical vertebra. Neurol India; 2008 Jan-Mar;56(1):84-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromyxoid fibroma is a rare benign bone tumor representing less than 0.5% of all bone tumors.
  • A presumptive diagnosis of a bony tumor such as an aneurysmal bone cyst or a giant cell tumor involving the seventh vertebral body was made on plain X-rays, MRI and bone scan.
  • He underwent C7 central corpectomy, incomplete intralesional curettage with iliac bone grafting and C6 to T1 interspinous wiring.
  • The histological diagnosis was chondromyxoid fibroma.
  • On eight years' follow-up, CT scan showed no progression of the tumor with good alignment and fusion of the graft at the site of the corpectomy.
  • The authors conclude that corpectomy and iliac bone grafting for chondromyxoid fibroma has a good outcome on long-term follow-up.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Chondromatosis / complications. Fibroma / complications. Fibroma / pathology

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  • (PMID = 18310848.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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51. Gibbs CP, Lewis VO, Peabody T: Beyond bone grafting: techniques in the surgical management of benign bone tumors. Instr Course Lect; 2005;54:497-503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Beyond bone grafting: techniques in the surgical management of benign bone tumors.
  • The traditional surgical treatment of benign bone tumors has been curettage and autologous bone graft or marginal resection of expendable bones.
  • Recently, however, surgeons have been evaluating the results of treatments using limited surgical approaches, including percutaneous treatments, alternatives to autograft bone, and thermal or cytotoxic adjuvant therapies.
  • This process has been facilitated by the availability of multiple bone grafting materials and substitutes, the use of cross-sectional imaging, and technology such as that used with radiofrequency ablation.
  • Techniques using these therapies in two benign bone tumor models are described.
  • The use of percutaneous radiofrequency ablation, now used for both benign and malignant disease, is reviewed as a surgical alternative for osteoid osteoma.
  • The role of adjuvant therapies such as liquid nitrogen and phenol, as well as the indications for resection, are described in the management of giant cell tumors of bone.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Giant Cell Tumor of Bone / surgery. Osteoma, Osteoid / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Bone Transplantation / methods. Humans. Prosthesis Implantation / methods

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  • (PMID = 15948474.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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52. Akhlaghpoor S, Aziz Ahari A, Ahmadi SA, Arjmand Shabestari A, Gohari Moghaddam K, Alinaghizadeh MR: Histological evaluation of drill fragments obtained during osteoid osteoma radiofrequency ablation. Skeletal Radiol; 2010 May;39(5):451-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Osteoid osteoma (OO) is a benign bone tumor diagnosed mainly on the basis of the patient's history and radiological data.
  • The aim of this study was to assess the diagnostic value of a histological evaluation of the bone fragments obtained during radiofrequency ablation (RFA).
  • Bone fragments collected from the drill were examined by two experienced pathologists, independently.
  • In 27 cases (69.2%) this diagnosis was confirmed pathologically.
  • CONCLUSION: Histological confirmation of OO based on drill fragments is similarly frequent as previously reported for standard bone biopsy.
  • [MeSH-major] Biopsy / methods. Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Bone and Bones / pathology. Catheter Ablation / methods. Osteoma, Osteoid / diagnosis. Osteoma, Osteoid / surgery

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  • (PMID = 20204353.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
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53. Futani H, Okumura Y, Fukuda Y, Fukunaga S, Hasegawa S, Yoshiya S: Giant cell tumor of the sternum: a case report and review of the literature. Anticancer Res; 2008 Nov-Dec;28(6B):4117-20
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  • [Title] Giant cell tumor of the sternum: a case report and review of the literature.
  • Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor.
  • Extended curettage of the tumor was performed followed by polymethylmethacrylate (PMMA) filing.
  • In conclusion, even though sternal benign tumors are rare, GCT should be considered as one of the differential diagnoses in a patient presenting with a sternal lesion in the 5th or 6th decade of life.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Sternum / pathology
  • [MeSH-minor] Bone Cements. Female. Humans. Middle Aged. Polymethyl Methacrylate. Reconstructive Surgical Procedures / methods

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  • (PMID = 19192670.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Bone Cements; 9011-14-7 / Polymethyl Methacrylate
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54. Lindfors NC, Koski I, Heikkilä JT, Mattila K, Aho AJ: A prospective randomized 14-year follow-up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J Biomed Mater Res B Appl Biomater; 2010 Jul;94(1):157-64
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  • [Title] A prospective randomized 14-year follow-up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors.
  • A prospective randomized long-term follow-up study of bioactive glass (BG)-S53P4 and autogenous bone (AB) used as bone graft substitutes in benign bone tumor surgery during 1993-1997 was conducted.
  • MRI showed a mainly or partly fatty bone marrow, and in the large bone tumor group, remnants of glass granules were also observed.
  • BG-S53P4 is a safe and well-tolerated bone substitute with good long-term results.
  • BG-S53P4 does not disturb the growth of bone in children.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes. Bone Transplantation. Glass / chemistry

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  • [Copyright] (c) 2010 Wiley Periodicals, Inc.
  • (PMID = 20524190.001).
  • [ISSN] 1552-4981
  • [Journal-full-title] Journal of biomedical materials research. Part B, Applied biomaterials
  • [ISO-abbreviation] J. Biomed. Mater. Res. Part B Appl. Biomater.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / bioactive glass S53P4
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55. Zhong Z, Chen Q, Chen Y, Liu C: [Repair of bone defect due to tumor resection with self-setting CPC in children]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Oct;22(10):1196-9
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  • [Title] [Repair of bone defect due to tumor resection with self-setting CPC in children].
  • OBJECTIVE: To summarize the effect of self-setting CPC on the repair of bone defect after tumor resection in children.
  • METHODS: From December 1998 to December 2006, 32 patients with benign bone tumor were treated, and the bone defect was repaired by CPC.
  • There were 12 cases of non-ossifying fibroma, 8 of bone cyst, 7 of osteoid osteoma and 5 of fibrous dysplasia.
  • The bone defect was located in femur in 15 cases, in tibia in 8 cases, in humerus in 6 cases and in other positions in 3 cases.
  • The range of bone defect was 2.0 cm x 1.5 cm x 1.0 cm - 10.0 cm x 5.0 cm x 4.0 cm.
  • CPC spongiosa granules of 3-23 g were filled in 26 cases, including 3 children with pathologic fracture and internal fixation with plate, and injectable CPC of 5-20 mL was filled in 6 bone cyst cases.
  • The X-ray films showed that the implanted CPC began to fuse with the host bone 4-9 months (7 month on average) after operation.
  • Finally, bone matrix grew well and no recurrence was found.
  • CONCLUSION: CPC in repairing bone defect after benign bone tumor in children is a safe, economical, convenient and non-toxic method.
  • [MeSH-major] Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Bone Neoplasms / surgery. Bone Regeneration. Child. Child, Preschool. Female. Humans. Hydroxyapatites. Male. Wound Healing

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  • (PMID = 18979877.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites
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56. Kim WJ, Kim KJ, Lee SK, Choy WS: Solitary pelvic osteochondroma causing L5 nerve root compression. Orthopedics; 2009 Dec;32(12):922
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors.
  • Thus, surgical excision is not routinely recommended unless the tumor causes clinical symptoms or cosmetic distress.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / surgery. Decompression, Surgical / methods. Osteochondroma / complications. Osteochondroma / surgery. Pelvic Bones / radiography. Pelvic Bones / surgery. Radiculopathy / etiology. Radiculopathy / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968229.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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  • (PMID = 18401591.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Kim MS, Lee SY, Cho WH, Song WS, Koh JS, Lee JA, Yoo JY, Shin DS, Jeon DG: Prognostic effects of doctor-associated diagnostic delays in osteosarcoma. Arch Orthop Trauma Surg; 2009 Oct;129(10):1421-5
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  • RESULTS: Initial clinical impressions were of a benign bone tumor in 15 patients, fracture in 8, and infection in 3.
  • After initial inappropriate procedures, primary surgeons failed to send a tissue sample to a pathologist for definite diagnosis in 12 cases, and pathologists made incorrect diagnoses in the other 14.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteosarcoma / diagnosis

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  • (PMID = 19280203.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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59. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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60. Futani H, Fukunaga S, Nishio S, Yagi M, Yoshiya S: Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection. Anticancer Res; 2007 Nov-Dec;27(6C):4311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection.
  • BACKGROUND: Intraosseous lipoma is a rare benign bone tumor.
  • Curettage was performed through small bone fenestrations in the medial and lateral aspects under observation with a 2.7-mm-diameter Hopkins telescope.
  • The bone void was filled with beta-tricalcium phosphate (beta-TCP).
  • CONCLUSION: Endoscopically assisted curettage is feasible in patients with benign bone tumors of the calcanei to avoid a long period of non-weightbearing post-operatively.
  • [MeSH-major] Bone Neoplasms / surgery. Calcaneus / surgery. Curettage / methods. Endoscopy. Lipoma / surgery

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  • (PMID = 18214037.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 0 / beta-tricalcium phosphate
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61. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • [Cites] AJR Am J Roentgenol. 2000 Jun;174(6):1729-35 [10845514.001]
  • (PMID = 17378939.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1839090
  • [General-notes] NLM/ Original DateCompleted: 20070726
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62. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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63. Zuntini M, Pedrini E, Parra A, Sgariglia F, Gentile FV, Pandolfi M, Alberghini M, Sangiorgi L: Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation. Oncogene; 2010 Jul 1;29(26):3827-34
MedlinePlus Health Information. consumer health - Bone Cancer.

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  • Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome.
  • Although both benign conditions have been linked to defects in EXT1 or EXT2 genes, contradictory reports are present in the literature regarding the requirement of their biallelic inactivation for osteochondroma development.
  • Our results clearly indicate that, in most cases, biallelic inactivation of EXT genes does not account for osteochondromas formation; this mechanism should be regarded as a common feature for hereditary osteochondromas transformation and as an event that occurs later in tumor progression of solitary cases.
  • [MeSH-major] Bone Neoplasms / genetics. Gene Silencing. N-Acetylglucosaminyltransferases / genetics. Osteochondroma / genetics

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  • (PMID = 20418910.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
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64. Ozyurek S, Rodop O, Kose O, Cilli F, Mahirogullari M: Aneurysmal bone cyst of the fifth metacarpal. Orthopedics; 2009 Aug;32(8)
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  • [Title] Aneurysmal bone cyst of the fifth metacarpal.
  • Aneurysmal bone cyst is a rare, rapidly growing, and destructive benign bone tumor that even more rarely involves the bones of the hand.
  • Various treatment options for aneurysmal bone cyst have been reported in the literature, but controversy exists regarding optimal treatment.
  • Physical and radiographic examination of the hand was consistent with aneurysmal bone cyst.
  • After biopsy, pathologic examination confirmed the diagnosis of aneurysmal bone cyst.
  • En-block resection of the tumor and autologous bicortical strut graft fixation with Kirschner wires was performed.
  • Radiographic examination demonstrated the osseous integration of the graft with no signs of recurrence.
  • [MeSH-major] Bone Cysts, Aneurysmal / radiography. Bone Cysts, Aneurysmal / surgery. Bone Transplantation. Metacarpal Bones / radiography. Metacarpal Bones / surgery. Osteotomy

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  • (PMID = 19708623.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Forsyth RG, De Boeck G, Baelde JJ, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone. J Bone Miner Res; 2009 Jan;24(1):70-7
MedlinePlus Health Information. consumer health - Bone Cancer.

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  • [Title] CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone.
  • Giant cell tumor of bone (GCTB) is a benign bone tumor with a shown clinical behavior of local recurrences and rare distant metastases.
  • Nineteen GCTB tumor samples of 19 patients were studied.
  • [MeSH-major] Antigens, CD / biosynthesis. Antigens, CD14 / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Bone Neoplasms / metabolism. Giant Cell Tumors / metabolism. Osteoclasts / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Integrin alphaV / biosynthesis. Leukocytes, Mononuclear / metabolism. Male. Middle Aged. Neoplasm Metastasis. Receptor Activator of Nuclear Factor-kappa B / biosynthesis. Sialic Acid Binding Ig-like Lectin 3

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  • (PMID = 18767926.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD33 protein, human; 0 / Integrin alphaV; 0 / Receptor Activator of Nuclear Factor-kappa B; 0 / Sialic Acid Binding Ig-like Lectin 3
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66. Durand S, Hamcha H, Pannier S, Padovani JP, Finidori G, Glorion C: [Fibrous dysplasia of the proximal femur in children and teenagers: surgical results in 22 cases]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Feb;93(1):17-22
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  • [Transliterated title] La dysplasie fibreuse de l'extrémité proximale du fémur chez l'enfant et l'adolescent: résultats du traitement chirurgical dans 22 cas.
  • PURPOSE OF THE STUDY: Fibrous dysplasia is a rare benign bone tumor which occurs preferentially in the proximal femur.
  • For the monostotic forms, the type of treatment depended on the size of the tumor and its localization but curettage was used in all cases.
  • Nearly total involution of the tumor was noted in 75% of patients.
  • [MeSH-major] Femur / surgery. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Density Conservation Agents / therapeutic use. Bone Nails. Child. Child, Preschool. Cohort Studies. Curettage. Diphosphonates / therapeutic use. Female. Fibrous Dysplasia, Monostotic / surgery. Fibrous Dysplasia, Polyostotic / surgery. Humans. Internal Fixators. Male. Osteotomy / instrumentation. Osteotomy / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 17389820.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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67. Yanagawa T, Watanabe H, Shinozaki T, Takagishi K: Curettage of benign bone tumors without grafts gives sufficient bone strength. Acta Orthop; 2009 Feb;80(1):9-13
MedlinePlus Health Information. consumer health - Bone Cancer.

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  • [Title] Curettage of benign bone tumors without grafts gives sufficient bone strength.
  • BACKGROUND AND PURPOSE: The defect that results after curettage of a bone tumor is usually filled in the same way.
  • We report the outcome in patients with benign bone tumors that were treated with curettage but no filling.
  • PATIENTS AND METHODS: We retrospectively studied 78 patients (mean age at the time of operation was 27 (6-73) years, 44 men) who had had a benign bone tumor curetted with no filling of the defect.
  • The commonest tumor types were giant cell tumor of bone (27), fibrous dysplasia (13), enchondroma (9), and simple bone cyst (7).
  • Local recurrence occurred in 9 patients; 7 of them had a giant cell tumor.
  • INTERPRETATION: Routine filling of curetted bone lesions does not appear to be necessary from a mechanical point of view.
  • [MeSH-major] Bone Neoplasms / surgery. Curettage / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Remodeling / physiology. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • [CommentIn] Acta Orthop. 2009 Feb;80(1):2-3 [19297784.001]
  • (PMID = 19234882.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC2823236
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68. Baena-Ocampo Ldel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R: Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol; 2009 Feb;13(1):16-21
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  • [Title] Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution.
  • A retrospective analysis of all bone tumors accessioned at a large referral center (Instituto Nacional de Rehabilitacion) in Mexico City between 2000 and 2005 is presented.
  • A total of 6216 biopsies and surgical resection specimens were reviewed during this period, of which 566 corresponded to bone tumors.
  • Benign bone tumors accounted for 71.6% of cases and malignant bone tumors for 28.4%.
  • The tumors affected men in 53.7% of cases and women in 46.3% of cases, with an average age at presentation of 25 years.
  • The femur was the most common location of the tumors (39.9%), followed by the tibia (17.7%) and humerus (11.8%).
  • The commonest malignant bone tumors were osteosarcoma (46.6%) and chondrosarcoma (8.7%).
  • Of malignant bone tumors, 18.6% corresponded to metastases of carcinomas from internal organs and 8.1% were multiple myeloma.
  • The most common benign bone tumor was osteochondroma (43.7%) followed by giant cell tumor of bone (14.6%) and enchondroma (10.1%).
  • The age distribution showed a peak in children and adolescents comprised predominantly of benign lesions and a second peak in young adults that corresponded to malignant bone tumors (principally osteosarcoma).
  • Malignant bone tumors most often involved the femur, vertebra, and tibia.
  • Geographic location does not appear to represent a risk factor for any particular type of bone tumor and does not affect the age distribution, location, or histopathologic type of the lesions.
  • [MeSH-major] Bone Neoplasms / epidemiology. Bone Neoplasms / pathology. Chondrosarcoma / epidemiology. Chondrosarcoma / pathology. Osteosarcoma / epidemiology. Osteosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Chondroma / epidemiology. Chondroma / pathology. Female. Giant Cell Tumors / epidemiology. Giant Cell Tumors / pathology. Giant Cell Tumors / secondary. Humans. Incidence. Infant. Male. Mexico / epidemiology. Middle Aged. Osteochondroma / epidemiology. Osteochondroma / pathology. Referral and Consultation. Retrospective Studies. Risk Factors. Urban Population

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  • (PMID = 19118777.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Kitsoulis PV, Paraskevas G, Vrettakos A, Marini A: A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases J; 2009;2:9144

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eosinophilic granuloma is very rare benign bone tumor which presents in more than 90% in children under the age of ten.
  • A soft, movable, palpable and tender mass was found at the left temporal bone.
  • No periostic reaction or bone formation was noted.
  • An attempt to excise the tumor failed as it had already eroded the underlying temporal bone.
  • Histological diagnosis with dominance of Langerhans cells set the diagnosis.
  • No tenderness, swelling or recurrence is recorded until now.Eosinophilic granuloma is of unknown aetiology but uncontrolled proliferation of Langerhans cells, previous inflammations or tumors and autoimmune disorders are suspected.

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  • (PMID = 20062661.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803941
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70. Yagi M, Ninomiya K, Kihara M, Horiuchi Y: Symptomatic osteochondroma of the spine in elderly patients. Report of 3 cases. J Neurosurg Spine; 2009 Jul;11(1):64-70
Genetic Alliance. consumer health - Osteochondroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Whereas osteochondroma is a common benign bone tumor in adolescence, it is rarely observed in elderly patients.
  • In the second case, total removal of the tumor was effective in alleviating clinical symptoms.
  • The pathology of psoriatic arthritis was the accelerating bone turnover and ankylosis.
  • In this report, the authors show that pathological accelerating bone turnover such as psoriatic arthritis may be a possible mechanism for the onset of the enlargement of osteochondromas in elderly patients.
  • [MeSH-major] Osteochondroma / diagnosis. Osteochondroma / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 19569943.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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71. Abula A, Abaiyedula A, Yusufu A, Liu C, Huang H: [Preliminary clinical application of cancellous granule-type calcium phosphate cement]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Sep;24(9):1100-2
MedlinePlus Health Information. consumer health - Bone Grafts.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.
  • METHODS: Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement.
  • There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case).
  • The size of bone defect was 1-5 cm.
  • Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).
  • Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone.
  • X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.
  • CONCLUSION: Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.
  • [MeSH-major] Bone Cements. Bone Transplantation / instrumentation. Calcium Phosphates / therapeutic use

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  • (PMID = 20939483.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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72. Altay M, Bayrakci K, Yildiz Y, Erekul S, Saglik Y: Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients. J Orthop Sci; 2007 Sep;12(5):415-23
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients.
  • BACKGROUND: Secondary malignancies arising from benign bone tumors are rare.
  • Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up.
  • In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated.
  • METHODS: Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation.
  • RESULTS: The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%).
  • The average time between the initial diagnosis and malignant transformation was 9.8 years.
  • The tumors generally were well differentiated.
  • Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months.
  • One patient is alive with tumor at 104 months.
  • CONCLUSIONS: Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation.
  • Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm.
  • [MeSH-major] Bone Neoplasms / pathology. Cartilage / pathology. Chondrosarcoma / secondary. Neoplasms, Second Primary / pathology. Osteochondroma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 17909925.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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73. Chin KR, Kim JM: A rare anterior sacral osteochondroma presenting as sciatica in an adult: a case report and review of the literature. Spine J; 2010 May;10(5):e1-4
MedlinePlus Health Information. consumer health - Sciatica.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND CONTEXT: Osteochondroma is the most common primary benign bone tumor and is usually located in the metaphyses of long bones and rarely in the spine or anterior sacrum.
  • In general, when osteochondroma causes pain in an adult, we should think that some structure is impinged or that it could have initiated a malignant transformation, so en bloc excision should be used to remove the tumor and histologic studies performed to assess for malignant transformation.
  • [MeSH-major] Osteochondroma / diagnosis. Sacrum. Sciatica / etiology

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20421072.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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74. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Daghfous M, Charfi H, Turki M, Maalla R, Baccari S, Tarhouni L: [Chondromyxoid fibroma. A case report of location in the phalanx of the thumb]. Chir Main; 2007 Jun;26(3):159-64
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  • Chondromyxoid Fibroma is a rare benign osseous tumor especially in the hand, because the hand represents less than 3% of all osseous locations.
  • It can causes problems of differential diagnosis with several types of tumors and in particular with chondrosarcoma, for which the management is totally different.
  • We report a case of location of a chondromyxoid fibroma in a phalanx of the thumb, which caused problems of differential diagnosis with chondroma and chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Fibroma / pathology. Thumb / pathology

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  • (PMID = 17590372.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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76. Manjunatha BS, Nagarajappa D: Osteoid osteoma. Indian J Dent Res; 2009 Oct-Dec;20(4):514-5

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  • Osteoid osteoma is a benign tumor of the bone which arises from osteoblasts and is extremely rare in jaws.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Fibroma, Ossifying / diagnosis. Humans. Mandibular Diseases / diagnosis. Osteitis / diagnosis. Osteoblastoma / diagnosis

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  • (PMID = 20139585.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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77. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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78. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7

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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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80. Li Y, Liang Q, Wen YQ, Chen LL, Wang LT, Liu YL, Luo CQ, Liang HZ, Li MT, Li Z: Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. Cancer Genet Cytogenet; 2010 Apr 15;198(2):97-106
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  • [Title] Comparative proteomics analysis of human osteosarcomas and benign tumor of bone.
  • Proteins extracted from osteosarcoma tissue and benign bone tumors, including osteoblastoma, chondroblastoma, and giant cell tumor of bone, were examined using two-dimensional gel electrophoresis followed by mass spectrometry analysis and database searches.
  • Aberrant expression of cytoskeletal- and microtubule-associated proteins in osteosarcoma may provide an advantage for tumor invasion and metastasis by affecting the stability of microtubule, which consequently influences the prognosis of patients.
  • [MeSH-major] Bone Neoplasms / metabolism. Neoplasm Proteins / analysis. Osteoblastoma / metabolism. Osteosarcoma / metabolism. Proteomics / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Bone and Bones / metabolism. Bone and Bones / pathology. Child. Chondroblastoma / metabolism. Chondroblastoma / pathology. Female. Giant Cell Tumor of Bone / metabolism. Giant Cell Tumor of Bone / pathology. Humans. Male. Middle Aged. Proteome / analysis. Proteome / metabolism. Young Adult


81. Sinici E, Tunay S, Kiliç E, Erler K, Altinmakas M: [Psychological evaluation of patients with benign musculoskeletal system tumors]. Acta Orthop Traumatol Turc; 2006;40(3):199-201
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  • [Title] [Psychological evaluation of patients with benign musculoskeletal system tumors].
  • [Transliterated title] Benign kas-iskelet sistemi tümörü olan hastalarda psikolojik durum değerlendirmesi.
  • OBJECTIVES: This study was designed to determine to what extent psychological status was affected by sociodemographic characteristics and by being informed about the diagnosis in patients with benign musculoskeletal tumors.
  • METHODS: The study included 112 male patients (mean age 23.8 years; range 20 to 35 years) who were hospitalized for benign tumors of the musculoskeletal system.
  • A questionnaire was administered to all the patients concerning their sociodemographic characteristics and the status of their knowledge about the diagnosis.
  • RESULTS: The depression level was not correlated with the localization (upper or lower extremity) of the musculoskeletal system tumor, the marital status of the patient, and the presence or absence of knowledge of the patient about the diagnosis (p>0.05).
  • [MeSH-major] Anxiety Disorders. Bone Neoplasms / psychology. Muscle Neoplasms / psychology

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  • (PMID = 16905891.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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82. Güneş D, Mutafoğlu-Uysal K, Sarialioğlu F, Cakmakçi H, Olgun N: Aneurysmal bone cyst of rib presenting as a huge chest wall mass. Turk J Pediatr; 2009 Jan-Feb;51(1):82-5

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  • [Title] Aneurysmal bone cyst of rib presenting as a huge chest wall mass.
  • Aneurysmal bone cyst is a rare benign tumor of the bone that can be difficult to distinguish from malignant tumors, especially when it presents in an unusual location.
  • Herein, we report a six-year-old girl with a primary aneurysmal bone cyst in an uncommon location.
  • She was successfully treated with total excision of tumor without any complication.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Ribs. Thoracic Wall / pathology

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  • (PMID = 19378899.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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83. Wong KC, Kumta SM, Tse LF, Ng EW, Lee KS: Navigation Endoscopic Assisted Tumor (NEAT) surgery for benign bone tumors of the extremities. Comput Aided Surg; 2010;15(1-3):32-9
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  • [Title] Navigation Endoscopic Assisted Tumor (NEAT) surgery for benign bone tumors of the extremities.
  • A novel technique of using both a navigation system and an endoscope in intra-lesional curettage of benign bone tumors enables safe and adequate tumor removal via a minimal access approach.
  • We performed curettage of benign bone tumors in five consecutive patients (4 female, 1 male, mean age 31.4 years) using a commercial CT-based navigation system supplemented by visual guidance through a shoulder arthroscope.
  • The bone defect was filled with bone cement in four patients and with artificial bone substitute in one patient.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroblastoma / surgery. Endoscopy / methods. Extremities / surgery. Giant Cell Tumor of Bone / surgery. Surgery, Computer-Assisted / methods

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  • (PMID = 20433316.001).
  • [ISSN] 1097-0150
  • [Journal-full-title] Computer aided surgery : official journal of the International Society for Computer Aided Surgery
  • [ISO-abbreviation] Comput. Aided Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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84. Lee VN, Nithyananth M, Cherian VM, Amritanand R, Venkatesh K, Sundararaj GD, Raghuram LN: Preoperative embolisation in benign bone tumour excision. J Orthop Surg (Hong Kong); 2008 Apr;16(1):80-3
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  • [Title] Preoperative embolisation in benign bone tumour excision.
  • PURPOSE: To assess the role of preoperative embolisation in benign bone tumour excision.
  • METHODS: 3 men and 3 women aged 19 to 35 (mean 23) years with either a giant cell tumour or an aneurysmal bone cyst in limb girdle sites underwent preoperative embolisation a day prior to wide local excision by the same surgeon.
  • Tumour size, blood loss, wound healing, infection, and tumour recurrence were assessed.
  • No tumour recurred within a minimum 5-year follow-up.
  • CONCLUSION: Preoperative embolisation is useful in the management of vascular and aggressive bone tumours located at limb girdle sites where a tourniquet cannot be used.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Embolization, Therapeutic. Giant Cell Tumor of Bone / surgery. Preoperative Care

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  • (PMID = 18453665.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Vergara HF, Ortiz DA, Martínez BH, Mosiñoz RM, Arellano JA: [Hand reconstructive surgery secondary to giant cell tumor]. Acta Ortop Mex; 2010 Sep-Oct;24(5):345-50
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  • [Title] [Hand reconstructive surgery secondary to giant cell tumor].
  • [Transliterated title] Cirugía reconstructiva de mano secundario a tumor de células gigantes.
  • The giant cell tumor of the bone is a neoplastic low grade lesion that usually appears in the epiphyseal or metaphyseal region of the long bones.
  • The lesion is usually solitary and becomes symptomatic when a considerable proportion of the bone has been destroyed.
  • It is thought to represent approximately 19% of the benign bone tumors and 9% of all the primary bone tumors, according to a review by Schajowicz.
  • The treatment of the giant cell tumor is controversial and the literature is confusing.
  • The giant cell tumor is located mainly in the hand.
  • Its potential aggressiveness makes us consider it in the differential diagnosis of the tumor lesions affecting the hand.
  • The purpose of this research work is to describe our experience with the treatment of the giant cell tumor in three cases that presented as a lytic, expansive lesion affecting the bones of the hand.
  • They were treated with tumor resection and a bone graft to fill the defect.
  • [MeSH-major] Bone Neoplasms / surgery. Finger Phalanges. Giant Cell Tumor of Bone / surgery

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  • (PMID = 21246807.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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86. Lindfors NC, Heikkilä JT, Aho AJ: Long-term evaluation of blood silicon and ostecalcin in operatively treated patients with benign bone tumors using bioactive glass and autogenous bone. J Biomed Mater Res B Appl Biomater; 2008 Oct;87(1):73-6
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  • [Title] Long-term evaluation of blood silicon and ostecalcin in operatively treated patients with benign bone tumors using bioactive glass and autogenous bone.
  • In a study on 25 patients with verified benign bone tumors, bioactive glass (BG) and autogenous bone (AB) were used as bone-graft substitutes.
  • No significant difference in blood silicon concentration between the BG group or the AB group could statistically be observed (p = 0.5400), and neither did the size of the bone tumor (p = 0.4259) nor the follow-up time affect the results (p = 0.2094).
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes / therapeutic use. Bone Transplantation. Glass

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18433009.001).
  • [ISSN] 1552-4981
  • [Journal-full-title] Journal of biomedical materials research. Part B, Applied biomaterials
  • [ISO-abbreviation] J. Biomed. Mater. Res. Part B Appl. Biomater.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes; 104982-03-8 / Osteocalcin; Z4152N8IUI / Silicon
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87. Adams SC, Potter BK, Robinson PG, Temple HT: Giant cell tumor of the distal femur associated with complete tumor necrosis. Orthopedics; 2010 Sep;33(9):688
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  • [Title] Giant cell tumor of the distal femur associated with complete tumor necrosis.
  • Giant cell tumor is a benign tumor of bone with a predilection for juxta-articular locations.
  • Although not malignant, giant cell tumor often exhibits unpredictable and locally aggressive behavior, and in rare cases can metastasize in the absence of histologic malignancy.
  • Partial tumor necrosis has been infrequently reported within typical giant cell tumor.
  • A 17-year-old girl presented with a right distal femur giant cell tumor associated with complete tumor necrosis on histopathologic analysis.
  • The etiology, prevalence, and implications of complete necrosis in previously untreated giant cell tumor of bone remain unclear, as there are no previously published reports.
  • There were no radiographic signs of the necrotic tumor space remodeling with new bone.
  • The patient was treated with standard extended intralesional curetting through a generous cortical window permitting visualization of the entire lesion, and systematic high speed burring and thermal electrocautery ablation of the periphery, followed by micro particulate allogenic bone grafting.
  • At short-term follow-up, she had healed well with no evidence of tumor recurrence.
  • This article presents the first case, to our knowledge, of complete spontaneous tumor necrosis in a previously untreated bone giant cell tumor.
  • Increased understanding of spontaneous tumor necrosis associated with giant cell tumor may help guided future targeted medical and surgical treatment modalities.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20839701.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Schindler OS, Cannon SR, Briggs TW, Blunn GW: Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours. J Orthop Surg (Hong Kong); 2008 Apr;16(1):66-74
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  • [Title] Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.
  • PURPOSE: To report the use of a composite ceramic bone graft substitute containing calcium sulphate and hydroxyapatite (HA) in the treatment of large expansive osteolytic benign bone tumours.
  • METHODS: 4 women and 9 men aged 8 to 49 (mean, 22) years with aneurysmal bone cysts (n=6) or giant cell tumours (n=7) in the epi- or meta-physeal areas of the lower limbs underwent curettage, phenolisation, and filling with bone graft substitute containing calcium sulphate and HA.
  • The mean tumour size was 38.5 (range, 18-65) ml.
  • Range of movement, Musculoskeletal Tumor Society Rating Score (MTSRS), and haematological and blood biochemical parameters were measured.
  • RESULTS: Two patients had recurrence at 7 and 9 months, both progressed to grade-III giant cell tumours.
  • CONCLUSION: Composite bioceramic osteoconductive grafts, which combine porous HA with calcium sulphate, provide a framework for human osteogenesis and avoid donor-site morbidity (autologous bone graft harvesting).
  • Tumour recurrence remains a major concern especially in young patients, as revision invariably requires removal of additional bone, potentially compromising joint integrity.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Bone Substitutes / therapeutic use. Ceramics / therapeutic use. Durapatite / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Female. Femoral Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Tibia / surgery

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  • (PMID = 18453663.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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89. Saikia KC, Bhattacharya TD, Bhuyan SK, Talukdar DJ, Saikia SP, Jitesh P: Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects. Indian J Orthop; 2008 Apr;42(2):169-72

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  • [Title] Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects.
  • BACKGROUND: Synthetic bio-inert materials are currently used as an alternative to autogenous bone graft.
  • The purpose of this study is to analyse the use of HA and beta-TCP in their ceramic forms as a bone graft substitute in filling bone voids after curettage of benign bone tumors.
  • MATERIALS AND METHODS: Twenty-four patients in the age range of 3.5-55 years (mean 14.3 years) having benign bone tumors with bone defects were filled with bone graft substitute following curettage.
  • In 20 patients bone defects were filled with block/granules of HA ceramic and in four with beta-TCP.
  • CONCLUSION: Calcium hydroxyapatite and beta-TCP are excellent bone graft substitutes for autogenous bone graft in filling voids after curettage of benign bone tumors.

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  • (PMID = 19826522.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2759621
  • [Keywords] NOTNLM ; Benign bone tumor / bone graft substitute / calcium phosphate ceramic / hydroxyapatite
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90. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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91. Li Y, Dang TA, Shen J, Perlaky L, Hicks J, Murray J, Meyer W, Chintagumpala M, Lau CC, Man TK: Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics; 2006 Jun;6(11):3426-35
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  • [Title] Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma.
  • Osteosarcoma (OS) is the most common malignant bone tumor in children.
  • To identify a plasma proteomic signature that can detect OS, we used SELDI MS to perform proteomic profiling on plasma specimens from 29 OS and 20 age-matched osteochondroma (OC) patients.
  • Nineteen statistically significant ion peaks that were differentially expressed in OS when compared with OC patients were identified (p < 0.001 and false discovery rate < 10%).
  • Using the proteomic profiles, we constructed a multivariate 3-nearest neighbors classifier to distinguish OS from OC patients with a sensitivity of 97% and a specificity of 80% based on external leave-one-out crossvalidation.
  • The higher plasma level of SAA in OS patients was further validated by Western blotting when compared to that of osteochrondroma patients and normal subjects as reference.
  • The classifier based on this plasma proteomic signature may be useful to differentiate malignant bone cancer from benign bone tumors and for early detection of OS in high-risk individuals.
  • [MeSH-major] Biomarkers, Tumor / blood. Blood Proteins / analysis. Bone Neoplasms / metabolism. Osteosarcoma / metabolism. Proteome / analysis
  • [MeSH-minor] Adolescent. Adult. Child. Diagnosis, Differential. Humans. Osteochondroma / diagnosis. Protein Array Analysis. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 16673437.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA81465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / Proteome
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92. Lee YG, Cho CW: Benign osteoblastoma located in the parietal bone. J Korean Neurosurg Soc; 2010 Aug;48(2):170-2

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  • [Title] Benign osteoblastoma located in the parietal bone.
  • Benign osteoblastoma is an uncommon primary bone tumor, extremely rare in calvarium.
  • We present a case of a 25-year-old female with an osteoblastoma of parietal bone which was totally resected.
  • The authors discussed the clinical presentation, radiographic finding, differential diagnosis and management of the benign calvarial osteoblastoma with a review of the literature.

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  • (PMID = 20856669.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941863
  • [Keywords] NOTNLM ; Osteoblastoma / Parietal bone
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93. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976); 2008 Dec 1;33(25):E968-70
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  • SUMMARY OF BACKGROUND DATA: Osteoblastoma is a rare benign tumor of bone that is known to incite a localized inflammatory response.
  • These inflammatory features can simulate malignant behavior on MRI and can lead to misdiagnosis and unnecessarily aggressive resection unless one recognizes the classic benign features on CT.
  • RESULTS: A 9-year-old girl with back pain receives an MRI of the lumbar spine demonstrating a sacral tumor with potentially malignant features including extensive marrow edema and enhancement.
  • A CT demonstrates a well-circumscribed lesion without lytic changes or malignant bone formation.
  • A benign lesion was favored given the CT features and conservative resection was performed.
  • Final pathologic diagnosis was osteoblastoma.
  • CONCLUSION: This case illustrates that the MRI findings for osteoblastoma can be misleading and caution should be used when evaluating benign tumors with known inflammatory responses on MRI.
  • CT features seem to more accurately reflect the true nature and extent of the tumor.
  • [MeSH-major] Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Inflammation / diagnosis. Inflammation / radiography. Inflammation / surgery. Lumbar Vertebrae / pathology. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery

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  • (PMID = 19050575.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am; 2009 Aug;17(3):469-87, vi
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  • [Title] MR imaging of primary bone tumors and tumor-like conditions in children.
  • This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population.
  • Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma.
  • Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis.
  • The use of MR imaging in the diagnosis of these lesions is discussed, and the text is enhanced with imaging examples of the lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Bone Cysts / diagnosis. Bone Cysts / pathology. Cartilage Diseases / diagnosis. Cartilage Diseases / pathology. Child. Contrast Media. Humans

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  • (PMID = 19524197.001).
  • [ISSN] 1557-9786
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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95. Colombo F, Casentini L, Cavedon C, Scalchi P, Cora S, Francescon P: Cyberknife radiosurgery for benign meningiomas: short-term results in 199 patients. Neurosurgery; 2009 Feb;64(2 Suppl):A7-13

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  • [Title] Cyberknife radiosurgery for benign meningiomas: short-term results in 199 patients.
  • OBJECTIVE: To present initial, short-term results obtained with an image-guided radiosurgery apparatus (CyberKnife; Accuray, Inc., Sunnyvale, CA) in a series of 199 benign intracranial meningiomas.
  • All patients were either symptomatic and/or harboring growing tumors.
  • Ninety-nine tumors involved the cavernous sinus; 28 were in the posterior fossa, petrous bone, or clivus; and 29 were in contact with anterior optic pathways.
  • Twenty-two tumors involved the convexity, and 21 involved the falx or tentorium.
  • Tumor volumes varied from 0.1 to 64 mL (mean, 7.5 mL) and radiation doses ranged from 12 to 25 Gy (mean, 18.5 Gy).
  • In 150 patients with lesions larger than 8 mL and/or with tumors situated close to critical structures, the dose was delivered in 2 to 5 daily fractions.
  • The tumor volume decreased in 36 patients, was unchanged in 148 patients, and increased in 7 patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19165077.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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96. Zehlicke T, Punke C, Boltze C, Pau HW: Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma). Neurologist; 2008 Jan;14(1):52-5
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  • [Title] Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma).
  • OBJECTIVE: Presentation of the clinical features of 2 very rare middle ear tumors in which the guiding symptom was facial palsy.
  • MATERIAL AND METHODS: Illustrative case reports about a myxoma and a carcinoid tumor of the middle ear associated with peripheral facial palsy.
  • Moreover, both tumor entities are typically found in organs other than the ear; if located in the middle ear, those neoplasms grow rather superficially.
  • If the facial weakness starts together with symptoms suggesting an inflammatory process, the differential diagnosis may be focused first on diseases like herpes zoster oticus and a severe course of acute purulent otitis media.
  • We report the cases of 2 rare middle ear tumors causing facial palsy.
  • [MeSH-major] Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle / pathology. Facial Paralysis / pathology. Myxoma / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Facial Nerve / pathology. Facial Nerve / physiopathology. Hearing Loss / etiology. Hearing Loss / pathology. Hearing Loss / radiography. Herpes Zoster Oticus / diagnosis. Humans. Male. Mastoid / pathology. Mastoid / radiography. Mastoid / surgery. Middle Aged. Neurosurgical Procedures. Otitis Media / diagnosis. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / radiography. Tomography, X-Ray Computed. Treatment Outcome. Vertigo / etiology. Vertigo / pathology. Vertigo / radiography

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  • (PMID = 18195660.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Papachristou DJ, Goodman MA, Cieply K, Hunt JL, Rao UN: Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis. Hum Pathol; 2006 Jul;37(7):890-8
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  • [Title] Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis.
  • Chondroblastoma (CBL) is a benign neoplasm of bone for which the genomic characteristics remain unclear.
  • Tumors were subjected to microdissection and polymerase chain reaction using 17 markers located near genes on chromosomes 5, 9, 11, 13, 17, and 19.
  • Fluorescence in situ hybridization was also performed on tumors displaying allelic losses, with dual-color probes for 9p, 17p, and 13q.
  • Loci with LOH in both tumor types suggest possible involvement of the genes p53, RB1, CDKN2/p16, ERC, and XRCC in tumorigenesis.
  • The role of p53 in CBL is uncertain; however, given the benign behavior of this tumor, it is probably unrelated to tumor progression.
  • [MeSH-major] Bone Neoplasms / genetics. Chondroblastoma / genetics. Chondrosarcoma / genetics. In Situ Hybridization, Fluorescence. Loss of Heterozygosity


98. Erlemann R: Imaging and differential diagnosis of primary bone tumors and tumor-like lesions of the spine. Eur J Radiol; 2006 Apr;58(1):48-67

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  • [Title] Imaging and differential diagnosis of primary bone tumors and tumor-like lesions of the spine.
  • Primary bone tumors and tumor-like lesions of the spine and sacrum are rare.
  • A wide variety of benign and malignant lesions can arise in the spine and sacrum.
  • Specific diagnosis is based on the location, matrix appearance and patient's age at time of presentation.
  • MRI can be helpful for further characterization and radiological differential diagnosis.
  • An overview of age distribution and imaging features including pattern for differential diagnosis is presented for the most frequent primary spinal bone tumors and tumor-like lesions.
  • [MeSH-major] Spinal Neoplasms / diagnosis. Spine / pathology
  • [MeSH-minor] Age Factors. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16431065.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 48
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99. Nagata S, Nishimura H, Uchida M, Hayabuchi N: [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors]. Nihon Igaku Hoshasen Gakkai Zasshi; 2005 Jan;65(1):30-6
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  • [Title] [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors].
  • PURPOSE: To evaluate the usefulness of diffusion-weighted MRI in distinguishing different components and in differentiating benign from malignant musculoskeletal tumors.
  • MATERIALS AND METHODS: Fifty-seven patients with musculoskeletal tumors underwent MR at our institution from October 1999 to April 2002.
  • We evaluated 57 tumors (9 bone tumors and 48 soft tissue tumors).
  • All tumors were classified into 8 groups (myxomatous, fibrous, cystic, cartilaginous, fatty components, hematomas, other benign tumors, and other malignant tumors).
  • RESULTS: ADC values of myxomatous, cystic, and cartilaginous components were significantly higher than those of other tumors.
  • In cartilaginous tumors, malignant tumor ADC values (2.33 +/- 0.44) were higher than those of benign tumors (2.13 +/- 0.13).
  • However, there was no significant difference between benign and malignant tumors.
  • Except for high-intensity components on T1-weighted imaging and low or homogeneously very high intensity components on T2-weighted imaging, there was a significant difference in ADC between malignant (1.35 +/- 0.40) and benign (1.97 +/- 0.50) tumors.
  • CONCLUSION: Within the limited number of cases, there was a significant difference in ADC between malignant and benign tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 15726897.001).
  • [ISSN] 0048-0428
  • [Journal-full-title] Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica
  • [ISO-abbreviation] Nihon Igaku Hoshasen Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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100. Toma CD, Svoboda M, Arrich F, Ekmekcioglu C, Assadian O, Thalhammer T: Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. J Pineal Res; 2007 Sep;43(2):206-13
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  • [Title] Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors.
  • The beneficial effects of melatonin on bone homeostasis have been shown in various diseases.
  • As this indoleamine causes dose-dependent modulation of bone-forming osteoblast and bone-resorbing osteoclast activities by receptor-independent and -dependent pathways, we investigated the expression of G-protein-coupled melatonin receptors (MTs) in malignant and non-malignant human bone lesions.
  • By TaqMan polymerase chain reaction (PCR), we analyzed 30 specimens from osteosarcoma and 11 from benign bone tumors for MT1-mRNA expression.
  • Although mean MT1-mRNA levels were similar (P = 0.596) in malignant (4.39 +/- 4.98-fold) and benign samples (4.64 +/- 6.81-fold), the highest MT1-mRNA levels (up to 27-fold) were observed in individual osteosarcomas, particularly, in two specimens of patients with local recurrence of the tumor.
  • Moreover, mean RANKL- and OPG-mRNA levels were similar in malignant and benign specimens (RANKL: 7.38 +/- 9.61-fold versus 3.57 +/- 3.11-fold, P = 0.207; OPG: 23.45 +/- 32.76 versus 8.07 +/- 7.23-fold, P = 0.133).
  • High expression levels of MT1-mRNA together with low OPG-mRNA were found in both osteosarcoma cell lines, while in normal human osteoblasts and bone marrow stromal cells, high OPG-mRNA levels were associated with low MT1-mRNA levels.
  • These data on the abundant expression of MT1-mRNA in human bone tumors and osteosarcoma cells lines suggest an important role for MT1 in bone pathology.
  • [MeSH-major] Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Gene Expression Regulation, Neoplastic. Receptor, Melatonin, MT1 / metabolism

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  • (PMID = 17645699.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Osteoprotegerin; 0 / RANK Ligand; 0 / RNA, Messenger; 0 / Receptor, Melatonin, MT1
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