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1. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P: Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):788-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.
  • Bone was the most common site for metastases (45%), followed by the head and neck (43%) and lung (36%).
  • Developing distant lesions within 10 years of the primary tumor and presence of metastases in multiple sites were independent predictors of survival on Cox regression analysis.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 16847191.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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2. Zhan HW, Xu W, Ye XJ, Zhao CL, Zhang H, Li J, Yao Q, Zhang LJ: Application of FDG-PET for detection of malignant lesions in patients with elevated blood tumor markers but without a history of malignancy. Mol Med Rep; 2009 Sep-Oct;2(5):837-42
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  • [Title] Application of FDG-PET for detection of malignant lesions in patients with elevated blood tumor markers but without a history of malignancy.
  • A total of 132 patients with increased levels of blood tumor markers but without a prior history of malignancy were examined.
  • The results of FDG-PET and conventional work-up (CWU) including computed tomography (CT), ultrasonography, radionuclide bone scintigraphy and endoscopy were compared.
  • The final diagnosis was based on pathological evidence, other medical imaging results and a follow-up of at least 6 months.
  • There were 61 patients with malignant lesions and 71 without (benign lesions, n=35; healthy individuals, n=36).
  • The average number of elevated tumor markers and the average increase in these tumor markers were greater in the malignant group than in the non-malignant group.
  • FDG-PET imaging revealed that the maximum standardized uptake value (SUVmax) of the major lesion in patients with malignant (n=61) and benign (n=35) tumors was not significantly related to increased levels of tumor markers (r=0.10, p<0.05).
  • In conclusion, FDG-PET imaging is a valuable tool for the detection of malignant lesions in patients with increased levels of blood tumor markers but without a history of malignancy.

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  • (PMID = 21475910.001).
  • [ISSN] 1791-3004
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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3. Whitten KA, Popielarczyk MM, Belote DA, McLeod GC, Mense MG: Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). Vet Pathol; 2006 Jan;43(1):62-4
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  • In humans and animals, ossifying fibroma is a benign neoplasm that most frequently affects the mandible, often resulting in cosmetic deformities and malocclusion.
  • Histopathologically, the neoplasm was composed of fibroblastic cells separated by abundant collagen.
  • Based on the histopathologic features, the tumor was diagnosed as an ossifying fibroma.
  • [MeSH-major] Bone Neoplasms / veterinary. Fibroma, Ossifying / veterinary. Maxilla / pathology. Rabbits
  • [MeSH-minor] Animals. Diagnosis, Differential

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  • (PMID = 16407489.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Mazzoleni S, Stomaci D, Rizzo A, Rigo L, Bressan E, Stellini E: Solitary neurofibroma of the palate. A case report. Minerva Stomatol; 2009 Sep;58(9):453-8
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  • The neurofibroma is a benign tumor of neuronal origin not frequently located in the oral cavity.
  • The possible association of this neoplasia with systemic pathologies, such as Von Recklinghausen's disease and multiple endocrine neoplasia, makes its diagnosis fundamental.
  • The diagnosis is, in most cases, quite complex, because of the neurofibroma's strong similarities with a great number of benign neoformations of the connective tissue, of the epithelium, and of the bone.
  • The immunohistochemical test, which resulted positive for S-100 and negative for the epithelial membrane antigen and keratin, allowed the diagnosis of a presumably benign lesion deriving from a neural differentiation.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Middle Aged. Molar. Neurofibromatoses / diagnosis. Oral Ulcer / etiology. Tooth Extraction

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  • (PMID = 19893470.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Feigin E, Abir R, Fisch B, Kravarusic D, Steinberg R, Nitke S, Avrahami G, Ben-Haroush A, Freud E: Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy. J Pediatr Surg; 2007 May;42(5):862-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The study group included 23 patients (median age = 14 years) with various types of cancer (hematologic, bone, ovarian, or intracranial); 11 patients were scheduled for chemotherapy, 11 patients had already undergone some form of chemotherapy before the ovarian tissue harvesting, and 1 patient was not scheduled for chemotherapy.
  • Ten underwent bone marrow transplantation after tissue retrieval.
  • In the other 2 patients, the ovary was preserved during inguinal hernia repair or tissue was obtained at laparotomy for a pelvic tumor.
  • All patients had benign operative and postoperative courses.

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  • (PMID = 17502200.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Rahmah NN, Horiuchi T, Nakayama J, Nitta J, Hongo K: Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma? Surg Neurol Int; 2010;1:60
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  • Imaging study revealed an enhanced intracranial extradural mass with bone destruction.
  • CONCLUSION: To our knowledge, this is a rare report of a patient with this tumor occurrence.
  • This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

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  • (PMID = 20975977.001).
  • [ISSN] 2152-7806
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2958332
  • [Keywords] NOTNLM ; Malignant melanoma / coexistence-losomarginal artery / meningioma / neural crest / recurrence
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7. Breuer C, Paul H, Zimmermann A, Braunstein S, Schaper J, Mayatepek E, Oh J: Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature. Eur J Pediatr; 2010 Aug;169(8):1037-40
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  • [Title] Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature.
  • The aneurysmal bone cyst is a very infrequent, benign bone lesion in children which rarely can be found at the craniofacial skeleton.
  • The cause of misleading diagnosis is often owing to the rapid growth of the lesion, sometimes associated with painful soft tissue swelling indicating an infectious origin or a malignant tumor.
  • Magnetic resonance imaging revealed the classic characteristics of aneurysmal bone cyst with severe destruction of the mandible.
  • Therefore, curative tumor embolization and complete surgical excision was successfully performed.
  • The aneurysmal bone cyst is a curable condition by radical excision, although relapse may occur when only incomplete excision is obtained.
  • Therefore, aneurysmal bone cyst should be considered early when children present with unusual, rapid-growing neoformations of the extremities or the facial region.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Diagnostic Errors. Magnetic Resonance Imaging. Mandible / pathology. Mandibular Diseases / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Acute Disease. Child. Diagnosis, Differential. Embolization, Therapeutic. Humans

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  • (PMID = 20107833.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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8. Luong TV, Salvagni S, Bordi C: Presacral carcinoid tumour. Review of the literature and report of a clinically malignant case. Dig Liver Dis; 2005 Apr;37(4):278-81
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  • [Title] Presacral carcinoid tumour. Review of the literature and report of a clinically malignant case.
  • Carcinoid tumours arising in the presacral region are extremely rare and they are usually benign.
  • We report the case of a 37-year-old black man with a clinically malignant carcinoid tumour (well differentiated endocrine carcinoma) occurring in a sacrococcygeal teratoma and already metastasised to pelvic nodes, liver and bone at the time of the initial diagnosis.
  • Such an aggressive behaviour of the presacral carcinoid tumours has never been described.
  • The derivation of these tumours from hindgut rests with reference to embryological development of the tailgut cysts is discussed.
  • [MeSH-major] Carcinoid Tumor / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / secondary. Humans. Immunohistochemistry. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Male. Pelvic Floor / pathology. Pelvic Floor / radiography. Pelvic Neoplasms / secondary. Phosphopyruvate Hydratase / analysis. Sacrococcygeal Region. Synaptophysin / analysis. Tomography, X-Ray Computed

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  • (PMID = 15788213.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 15
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9. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Mintz S, Velez I: Osteoid osteoma of the zygoma: report of an unusual case. J Am Dent Assoc; 2007 Jun;138(6):793-7
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  • BACKGROUND: Osteoid osteoma is a benign tumor of bone characterized by pain, usually occurring at night, that shows a dramatic response to aspirin.
  • On the basis of the images and the biopsy report, the authors made a diagnosis of osteoid osteoma.

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  • (PMID = 17545268.001).
  • [ISSN] 0002-8177
  • [Journal-full-title] Journal of the American Dental Association (1939)
  • [ISO-abbreviation] J Am Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin
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11. Buluç L, Arslan A, Müezzinoglu B, Yildiz DK, Sarlak AY: Chondrosarcoma of the talus: a case report. J Foot Ankle Surg; 2005 Jul-Aug;44(4):292-6
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  • A 27-year-old man with a chondrosarcoma arising from a preexisting benign tumor was treated by talectomy.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Talus

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  • (PMID = 16012437.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Aydoğdu K, Findik G, Agackiran Y, Kaya S, Karaoglanoglu N, Tastepe I: Primary tumors of the ribs; experience with 78 patients. Interact Cardiovasc Thorac Surg; 2009 Aug;9(2):251-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary tumors of the ribs; experience with 78 patients.
  • A retrospective study of primary tumors of the ribs (PTR) was conducted to review their clinical, radiological, and pathological features, as well as the early and long-term results of surgical management.
  • Forty-nine (63%) of the patients had benign lesions and 29 (37%) had malignant lesions.
  • In the group with malignant tumors, the main symptom was pain, but in the group with benign tumors, the main symptom was swelling.
  • Eight cases in the benign group and four cases in the malignant group were asymptomatic (accidental radiological findings in recruitment centers).
  • Most of the patients with PTR had benign lesions.
  • Surgery must consist of wide resection with tumor-free margins in order to provide the best chance for cure in both benign and malignant lesions.
  • [MeSH-major] Bone Neoplasms. Ribs

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  • (PMID = 19447801.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. Bertagna F, Bosio G, Biasiotto G, Savelli G, Rodella C, Giubbini R, Rosenbaum J, Alavi A: Plurifocal malignant peripheral nerve sheath tumor demonstrated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Jpn J Radiol; 2009 Oct;27(8):320-3
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  • [Title] Plurifocal malignant peripheral nerve sheath tumor demonstrated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography.
  • Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas that derive from peripheral nerves or from cells associated with the nerve sheath.
  • Computed tomography (CT) of the chest is the main imaging modality used to screen for distant disease, and bone scanning is considered useful for identifying selected metastases.
  • Fluorodeoxyglucose positron emission tomography (FDG-PET) has been useful for differentiating malignant nerve sheath tumors from benign lesions and appears to be able to forecast prognosis.
  • We report a case of a patient with neurofibromatosis 1 (NF1) with a histological diagnosis of MPNST, which was diagnosed by biopsy of a posterior right thigh mass examined by (18)F-FDG-PET/CT.
  • [MeSH-minor] Diagnosis, Differential. Fluorodeoxyglucose F18. Humans. Neurofibromatosis 1 / diagnostic imaging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 19856228.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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14. Spanu A, Solinas ME, Chessa F, Sanna D, Nuvoli S, Madeddu G: 131I SPECT/CT in the follow-up of differentiated thyroid carcinoma: incremental value versus planar imaging. J Nucl Med; 2009 Feb;50(2):184-90
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  • We assigned an incremental value to SPECT/CT when it provided better identification and interpretation of the foci of radioiodine uptake, more correct anatomic localization and characterization, and precise differentiation between tumor lesions and physiologic uptake.
  • SPECT/CT also showed occult lesions in the mediastinum, abdomen, and pelvis and identified small bone metastases unsuspected on planar imaging.
  • Globally, SPECT/CT had an incremental value over planar imaging in 67.8% of patients, modified therapeutic management in 35.6% of positive cases, and avoided unnecessary treatment in 20.3% of patients with only single benign lesions or physiologic uptake.

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  • [CommentIn] J Nucl Med. 2009 Aug;50(8):1386; author reply 1386 [19617337.001]
  • (PMID = 19164225.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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15. Kim TK, Kim KH, Kim CH, Shin SW, Kwon JY, Kim HK, Baik SW: Percutaneous vertebroplasty and facet joint block. J Korean Med Sci; 2005 Dec;20(6):1023-8
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  • It is surprising that about 24% of patients with benign osteoporotic vertebral fracture die within a year from respiratory infection and urinary tract infection because of coughing and voiding difficulties, depending on the sites of compression fractures.
  • The mean total lumbar spine fracture threshold of bone mineral density was 0.81+/-0.05 g/cm2.
  • The mean changes of numeric rating scale scores, Oswestry Disability Index except sex life, and Karnofsky performance status were -72.00, -83.50 and +60.62% in the osteoporosis group and -51.89, -45.02, and 69.03% in the tumor group.
  • [MeSH-minor] Aged. Bone Cements / therapeutic use. Female. Follow-Up Studies. Humans. Injections, Spinal. Male. Middle Aged. Minimally Invasive Surgical Procedures. Nerve Block. Orthopedic Procedures. Pain / physiopathology. Pain / surgery. Zygapophyseal Joint

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  • (PMID = 16361816.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Bone Cements
  • [Other-IDs] NLM/ PMC2779303
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16. Hörmann M: [Neuroblastoma in children]. Radiologe; 2008 Oct;48(10):940-5
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  • Neuroblastomas have a very heterogenic clinical presentation, ranging from relatively benign forms with the potential of spontaneous regression, to foudroyant malignant forms.
  • Over half of neuroblastomas must be classified as high-risk tumors with a markedly high rate of recurrence.
  • Despite multidisciplinary therapeutic approaches, the survival rate of children with this type of tumor is still below 40%.
  • An ever-growing amount of data from international studies dating from the early 1970s onwards, points to the necessity of re-evaluating the medical approach in establishing the diagnosis and staging, understanding tumor biology and pathology, as well as therapy planning.
  • [MeSH-major] Bone Marrow Neoplasms / diagnosis. Brain Neoplasms / diagnosis. Magnetic Resonance Imaging. Neuroblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Age Factors. Child. Child, Preschool. Humans. Infant. Infant, Newborn. Life Expectancy. Mass Screening. Neoplasm Staging. Paraneoplastic Syndromes / diagnosis. Positron-Emission Tomography. Prognosis. Quality of Life. Risk Factors. Ultrasonography


17. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Western Australia / epidemiology

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Abdel Razek AA, Castillo M: Imaging appearance of primary bony tumors and pseudo-tumors of the spine. J Neuroradiol; 2010 Mar;37(1):37-50
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  • [Title] Imaging appearance of primary bony tumors and pseudo-tumors of the spine.
  • We aim to review the imaging appearance of primary bony tumors of the spine and simulating lesions.
  • Benign bone tumors commonly appear as well-circumscribed, slow-growing lesions with a calcified or sclerotic matrix.
  • Malignancy is often aggressive permeative lesions with bone destruction, cortical invasion and associated soft-tissue mass.
  • CT is an excellent imaging modality for characterization of the tumor matrix, exact location, extension and osseous changes, while MR imaging is superior for evaluation of the associated soft-tissue mass, bone marrow infiltration and intraspinal extension.
  • The imaging appearance of primary spinal bone tumor in conjunction with the patient's age, gender and lesion location allows a high percentage of correct diagnosis.
  • Imaging plays an important role in diagnosis, characterization and extension of bone tumors of the spine which will help guide therapy.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Spinal Neoplasms / diagnosis. Spine / pathology. Spine / radiography. Tomography, X-Ray Computed / methods

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  • [Copyright] (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19781780.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 60
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19. Katori H, Nozawa A, Tsukuda M: Histopathological parameters of recurrence and malignant transformation in sinonasal inverted papilloma. Acta Otolaryngol; 2006 Feb;126(2):214-8
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  • MATERIAL AND METHODS: We analyzed the histopathological characteristics of 39 cases of IP using the following parameters: site of origin of tumor; presence of bone invasion; presence of inflammatory polyp; ratio of endophytic to exophytic lesions; ratio of neoplastic epithelium to stroma; presence of hyperkeratosis; presence of squamous epithelial hyperplasia; mitotic index; number of mucin globules; and number of eosinophils.
  • RESULTS: Malignancy was related to the presence of bone invasion (p=0.039), the absence of inflammatory polyp (p=0.033), increase in the ratio neoplastic epithelium:stroma (p=0.037), increase in hyperkeratosis (p=0.030), the presence of squamous epithelial hyperplasia (p=0.044), increase in the mitotic index (p=0.029) and a decrease in the number of eosinophils (p=0.037).
  • Clinically benign behavior was related to the presence of inflammatory polyp (p=0.010) and the absence of hyperkeratosis (p=0.008).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 16428203.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Mucins
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20. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer; 2010 Dec;49(12):1114-24
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  • [Title] EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene.
  • The diagnosis of myoepithelial (ME) tumors outside salivary glands remains challenging, especially in unusual clinical presentations, such as bone or visceral locations.
  • A few reports have indicated EWSR1 gene rearrangement in soft tissue ME tumors, and, in one case each, the fusion partner was identified as either PBX1 or ZNF444.
  • However, larger studies to investigate whether these genetic abnormalities are recurrent or restricted to tumors in soft tissue locations are lacking.
  • Sixty-six ME tumors mainly from soft tissue (71%), but also from skin, bone, and visceral locations, characterized by classic morphological features and supporting immunoprofile were studied.
  • A EWSR1-POU5F1 fusion was identified in a pediatric soft tissue tumor by 3'Rapid Amplification of cDNA Euds (RACE) and subsequently confirmed in four additional soft tissue tumors in children and young adults.
  • An EWSR1-PBX1 fusion was seen in five cases, whereas EWSR1-ZNF444 and FUS gene rearrangement was noted in one pulmonary tumor each.
  • In conclusion, EWSR1 gene rearrangement is a common event in ME tumors arising outside salivary glands, irrespective of anatomical location.
  • EWSR1-negative tumors were more often benign, superficially located, and showed ductal differentiation, suggesting the possibility of genetically distinct groups.
  • A subset of soft tissue ME tumors with clear cell morphology harbor an EWSR1-POU5F1 fusion, which can be used as a molecular diagnostic test in difficult cases.
  • These findings do not support a pathogenetic relationship between soft tissue ME tumors and their salivary gland counterparts.

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  • [Copyright] © 2010 Wiley-Liss, Inc.
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  • (PMID = 20815032.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins; 0 / pbx1 protein, human
  • [Other-IDs] NLM/ NIHMS377724; NLM/ PMC3540416
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21. Mazzocchi M, Martano A, Di Ronza S, Dodbiba E, Divona L, Scuderi N: Concomitant right subscapular and left olecranon elastofibroma followed by inversion of the lesions: case report. Anticancer Res; 2009 Feb;29(2):503-7
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  • Elastofibroma is a benign, poorly circumscribed, tumor-like condition involving, in the vast majority of cases, the subscapular region of elderly individuals, though isolated cases have been seen in the deltoid muscle, infraolecranon area, hip, thigh and stomach.
  • [MeSH-major] Bone Neoplasms / pathology. Fibroma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19331195.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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22. Deyrup AT, Monson DK, Dorfman HD: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol; 2008 Jul;16(3):308-10
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  • It is important to differentiate this benign osteoblastoma, a potentially locally aggressive tumor, from extraskeletal osteosarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Epithelioid Cells / pathology. Ossification, Heterotopic / pathology. Osteoblastoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18573786.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Ech-Charif S, Aubert S, Buob D, Verhulst P, Blomme V, Migaud H, Leroy X: [Giant cell tumor of soft tissues. Report of two cases]. Ann Pathol; 2006 Feb;26(1):26-9
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  • [Title] [Giant cell tumor of soft tissues. Report of two cases].
  • [Transliterated title] Tumeur à cellules géantes des tissus mous.
  • We report two cases of giant-cell tumour of soft tissue (TCG-TM).
  • The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg.
  • Pathological study revealed a tumour comparable to benign giant cell tumour of bone.
  • The patient is well without recurrence 10 months after the diagnosis.
  • Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells.
  • TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone.
  • The differential diagnosis includes other tumours rich in osteoclast-like cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Female. Giant Cells / pathology. Humans. Leukocytes, Mononuclear / pathology. Male. Middle Aged

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  • (PMID = 16841007.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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24. Benatiya Andaloussi I, Touiza E, Bhallil S, Oudidi A, Bouayed MA, Daoudi K, El Alami MN, Tahri H: Orbital osteoma: three case reports. Bull Soc Belge Ophtalmol; 2006;(300):73-9
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  • INTRODUCTION: Osteoma is the most frequent benign tumor of paranasal sinuses.
  • The management consisted in a surgical excision of the whole tumor by external approach, associated with a dacryocystorhinostomy.
  • Computed tomography images showed a fronto-ethmoidal process displaying a bone density consistent with an osteoma.
  • The tumor was removed through an external ethmoidectomy.
  • The computed tomography is of a great contribution, not only for diagnosis but also for the choice of the surgical approach.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Osteoma / diagnosis

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  • (PMID = 16903514.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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25. Bancroft LW, Peterson JJ, Kransdorf MJ: MR imaging of tumors and tumor-like lesions of the hip. Magn Reson Imaging Clin N Am; 2005 Nov;13(4):757-74
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  • [Title] MR imaging of tumors and tumor-like lesions of the hip.
  • In conclusion, a wide variety of tumors and tumor-like conditions have a predilection for the hip.
  • Radiographs can depict the extent of disease; any characteristic calcifications; and osseous changes, such as remodeling,periosteal reaction, or destruction.
  • MR imaging has emerged as the preferred imaging modality of choice for evaluating osseous and soft tissue masses of the hip by providing information for diagnosis and staging.
  • The MR imaging signal characteristics and enhancement patterns of malignant and benign hip tumors permit specific diagnoses in some cases.
  • Synovial-based tumor-like processes of the hip can be characterized by MR signal characteristics, such as the hemosiderin within PVNS or the cartilage within synovial chondromatosis.
  • Finally, MR imaging can serve to exclude underlying osseous or soft tissue tumors when radiographs display aggressive features of tumor-like processes.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hip Joint. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Sensitivity and Specificity

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  • (PMID = 16275582.001).
  • [ISSN] 1064-9689
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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26. Chekili S, Abdelghani KB, Hajri R, Laatar A, Mestiri M, Zakraoui L: [Intraosseous capillary hemangioma of the radial bone]. Rev Chir Orthop Reparatrice Appar Mot; 2008 Jun;94(4):413-6
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  • [Title] [Intraosseous capillary hemangioma of the radial bone].
  • [Transliterated title] Une tumeur osseuse rare au radius : hémangiome capillaire.
  • Hemangioma is a rare benign vascular tumor composed of dystrophic capillaries, preferentially located in the spinal region (70 %).
  • Bony localizations are exceptional, less than 1 % of cases in large series of bone tumors.
  • Magnetic resonance imaging revealed a defect of the shaft cortex without involvement of the central part of the bone, the endostium or the soft tissue.
  • Surgical resection was limited to the tumor.
  • The course was favorable with bone healing and gap filling, with normal elbow and wrist function.
  • This case illustrates a rare localization of this tumor rarely reported in major series.
  • [MeSH-major] Bone Neoplasms. Hemangioma, Capillary. Radius

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  • (PMID = 18555870.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Urresola A, Sáez F, Canteli B, Elorriaga R, López-Duque JC: [Desmoplastic fibroma of bone: a report of two cases]. Radiologia; 2007 May-Jun;49(3):205-10
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  • [Title] [Desmoplastic fibroma of bone: a report of two cases].
  • [Transliterated title] Fibroma desmoplásico óseo: a propósito de dos casos.
  • Desmoplastic fibroma is a rare bone tumor with benign, locally aggressive, lytic behavior.
  • Histologically, it is very similar to the more common and better known desmoid tumor.
  • We present two cases; the tumor was located in the proximal tip of the fibula in one case and in the proximal tip of the femur in the other.
  • In both cases, the lesions were lytic, expansive, with a trabeculated appearance and internal septa, and without mineralized osseous matrix.
  • At MRI, one of the tumors was very heterogeneous, with two differentiated areas on T2-weighted sequences: the upper zone was hypointense and the lower zone showed intermediate signal intensity.
  • We also describe the behavior of the tumor after the administration of intravenous Gadolinium: the upper zone showed no significant enhancement and the lower showed significant enhancement in the early phase.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibroma, Desmoplastic / diagnosis

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  • (PMID = 17524342.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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28. Singh R, Jain M, Siwach R, Rohilla RK, Kaur K: Unusual presentation of bizarre parosteal osteochondromatous lesion of the second toe (Nora's lesion). Foot Ankle Spec; 2010 Dec;3(6):347-51
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  • Bizarre parosteal osteochondromatous proliferation (BPOP) of bone is a rare benign neoplasm.
  • Although local excision of the tumor is the treatment of choice, the authors resorted to ray excision, as gangrenous changes and ulceration were present and there was the possibility of malignant change.
  • [MeSH-major] Bone Neoplasms / pathology. Foot Ulcer / pathology. Osteochondroma / pathology. Periosteum / pathology. Toes / pathology

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  • (PMID = 20624925.001).
  • [ISSN] 1938-7636
  • [Journal-full-title] Foot & ankle specialist
  • [ISO-abbreviation] Foot Ankle Spec
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Lu Y, Wang J, Xu Y, Koch AE, Cai Z, Chen X, Galson DL, Taichman RS, Zhang J: CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res; 2008 Apr;6(4):546-54
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  • A variety of tumor cells produce chemokines that promote tumor cell proliferation and chemotaxis.
  • We previously reported that CXCL16 production is increased in aggressive prostate cancer cells compared with the less aggressive tumor cells and benign cells as identified in a cytokine antibody array.
  • Consistent with our finding on CXCL16 protein production by prostate cancer cells, aggressive prostate cancer C4-2B and PC3 cells, as well as bone and liver metastatic tissues, expressed higher levels of both CXCL16 and CXCR6 mRNA compared with the less aggressive prostate cancer LNCaP cells, nonneoplastic PrEC and RWPE-1 cells, and benign prostate tissues, respectively.
  • Finally, we found that both interleukin-1beta and tumor necrosis factor alpha significantly induced CXCL16 production by prostate epithelial cells, thereby indicating that inflammatory cytokines may play a role in the CXCL16 induction.
  • [MeSH-minor] Cell Line, Tumor. Cell Movement / drug effects. Epithelial Cells / drug effects. Epithelial Cells / pathology. Gene Expression Regulation, Neoplastic / drug effects. Humans. Immunohistochemistry. Inflammation Mediators / metabolism. Interleukin-1beta / pharmacology. Male. Neoplasm Invasiveness. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Chemokine / genetics. Receptors, Chemokine / metabolism. Receptors, Virus / genetics. Receptors, Virus / metabolism. Tumor Necrosis Factor-alpha / pharmacology

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  • (PMID = 18344492.001).
  • [ISSN] 1541-7786
  • [Journal-full-title] Molecular cancer research : MCR
  • [ISO-abbreviation] Mol. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01-CA-93900
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL16 protein, human; 0 / CXCR6 protein, human; 0 / Chemokines, CXC; 0 / Chemotactic Factors; 0 / Inflammation Mediators; 0 / Interleukin-1beta; 0 / RNA, Messenger; 0 / Receptors, Chemokine; 0 / Receptors, Scavenger; 0 / Receptors, Virus; 0 / Tumor Necrosis Factor-alpha
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30. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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31. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Honig A, Rieger L, Kapp M, Krockenberger M, Eck M, Dietl J, Kämmerer U: Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study. BMC Cancer; 2006;6:199
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  • It has already been investigated as a marker of bone metastases in cancer patients.
  • In this study, which examined the value of serum TRAP concentrations as a marker of bone disease in breast cancer patients, we observed high concentrations of TRAP even in patients without bone metastases.
  • METHODS: TRAP concentrations in the serum of tumor patients were determined by ELISA.
  • RT-PCR and immunocytology were used to evaluate TRAP expression in cultured tumor cells.
  • RESULTS: A marked increase in serum TRAP concentrations was observed in patients with breast and ovarian cancer, regardless of the presence or absence of bone disease.
  • Expression of TRAP was absent in benign tissue or was much less marked than in the corresponding malignant tissue.
  • CONCLUSION: Overexpression of TRAP was detected in the cells of various different tumors.
  • [MeSH-minor] Control Groups. Enzyme-Linked Immunosorbent Assay. Female. Gene Expression. Humans. Immunohistochemistry. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 16869970.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.2 / Acid Phosphatase
  • [Other-IDs] NLM/ PMC1550422
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33. Kopacz J, Mazurkiewicz T, Warda E, Rogała W: Evaluation of the survivability of femoral shaft reconstructions after resection of tumor and tumor-like lesions. Ortop Traumatol Rehabil; 2005 Dec 30;7(6):611-5
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  • [Title] Evaluation of the survivability of femoral shaft reconstructions after resection of tumor and tumor-like lesions.
  • Background. The reconstruction of femoral shaft defects after tumor resection involves joining healthy bone fragments with plates or intramedullary rods, using methyl metacrylate cement or bone grafts.
  • Results. There were 37 bone metastases, 11 primary neoplasms, 1 eosiniphilic granuloma and 1 solitary bone cyst.
  • Long intramedullary fibula grafts were used to stabilize bone fragments in 2 patients with benign lesions.
  • The post-resection defect was filled with methyl metacrylate cement in 47 cases, and with bone chips in 3 cases.
  • There were 4 deep infections and 4 tumor recurrences in other patients.
  • Conclusions. Bone-cement union is the decisive factor in stabilizing fragments after a tumor has been resected from the femoral shaft and the defect filled with cement.
  • Bone cement should be used to fill the defect in patients treated for metastases to bone, but not in patients with a primary bone tumor.

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  • (PMID = 17611423.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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34. Kossmann N, Gallachi G: [Local pain of the shoulder - osteoid osteoma]. Praxis (Bern 1994); 2010 Mar 17;99(6):359-5; quiz 366
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  • The cause was later identified in CT as being an osteoid osteoma, a benign bone tumour with high vascularity in the core (nidus) and a surrounding region of sclerosis.
  • These tumours usually develop before the age of thirty and the pain responds exquisitely to non-steroidal antirheumatic medication.
  • The tumour was finally removed (CT-guided drilling excision) whereupon the symptoms disappeared.
  • [MeSH-major] Bone Neoplasms / diagnosis. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging. Osteoma, Osteoid / diagnosis. Scapula / pathology. Shoulder Pain / etiology. Tomography, Spiral Computed
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Young Adult

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  • (PMID = 20235025.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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35. Larralde M, Boggio P, Abad ME, Pagotto B, Castillo A: [Subungual exostosis in a 14 years old boy]. Arch Argent Pediatr; 2009 Aug;107(4):349-52
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  • [Transliterated title] Exostosis subungueal en un adolescente de 14 años.
  • Subungual exostosis is a benign bony outgrowth surrounded by a fibrocartilaginous capsule that mainly affects hallux terminal phalanx with subungual or periungular localization, and that clinically determines variable degree of nail plate or periungular soft tissues alterations, respectively, It is uncommon in childhood and more frequent in females.
  • Clinical suspicion is confirmed by the radiographic finding of a distinct trabecular bone growth arising from the dorsal aspect of the phalanx of the affected finger, on the lateral incidence.
  • We report a case of subungual exostosis located at the hallux in a 14-year-old boy suffering from subungual exostosis of the hallux that presented the characteristic triad of this entity: subungular tumor with nail plate deformity, digital pain and radiologic typical findings.

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  • (PMID = 19753444.001).
  • [ISSN] 1668-3501
  • [Journal-full-title] Archivos argentinos de pediatría
  • [ISO-abbreviation] Arch Argent Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Argentina
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36. Doak SH, Jenkins SA, Hurle RA, Varma M, Hawizy A, Kynaston HG, Parry JM: Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Cancer Genet Cytogenet; 2007 Jul 15;176(2):161-5
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  • [Title] Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer.
  • Abnormal expression of bone morphogenic proteins (BMP) has been reported in prostate cancer as compared to benign prostatic tissue.
  • Probes for fluorescence in situ hybridization for the BMP, BMP5, BMP7, and UC28 gene loci were developed and applied to archival sections with areas of adjacent benign epithelium, high-grade prostatic intraepithelial neoplasia, and prostate carcinoma.
  • No deletions of the gene loci examined were observed, but gain of BMP2, BMP5, BMP7, and UC28 occurred in 58, 50, 50, and 67% of tumor foci, respectively.
  • These aberrations in copy number may be caused by early events in tumor development because they were also present in 10-30% of high-grade prostatic intraepithelial hyperplasia foci.
  • In addition, one tumor demonstrated a tandem amplification of the UC28 gene locus.
  • Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue.
  • [MeSH-major] Bone Morphogenetic Proteins / genetics. Gene Dosage. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] Aged. Bone Morphogenetic Protein 2. Bone Morphogenetic Protein 5. Bone Morphogenetic Protein 7. Cell Nucleus / metabolism. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasm Staging. Transforming Growth Factor beta / genetics. Transforming Growth Factor beta / metabolism

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  • (PMID = 17656261.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP5 protein, human; 0 / BMP7 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 5; 0 / Bone Morphogenetic Protein 7; 0 / Bone Morphogenetic Proteins; 0 / Neoplasm Proteins; 0 / PBOV1 protein, human; 0 / Transforming Growth Factor beta
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37. Villanueva J, González A, Cornejo M, Núñez C, Encina S: Osteochondroma of the coronoid process. Med Oral Patol Oral Cir Bucal; 2006 May;11(3):E289-91
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  • Osteochondroma is the most common benign neoplasia of the skeleton.
  • In panoramic radiographs was evident a coronoid tumor localized in the union of zigomatic arch and bone.
  • Histopatological examinations revealed normal trabecular bone covered with hyaline cartilage.
  • The histopatological diagnosis was osteochondroma.
  • Clinical and pathological aspects, treatment and differential diagnosis with other lesions are discussed.

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  • (PMID = 16648770.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 13
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38. Tubbs RS, Kelly DR, Pugh JL, Loukas M, Oakes WJ: Benign fibrous histiocytoma of the skull base. Case report. J Neurosurg; 2007 Jan;106(1 Suppl):65-7
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  • [Title] Benign fibrous histiocytoma of the skull base. Case report.
  • The authors report the case of benign fibrous histiocytoma (BFH) of the skull base in an 11-month-old girl.
  • At the most recent follow-up examination--18 months postoperatively--the child was noted to be asymptomatic with no gross increase in tumor size.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Female. Follow-Up Studies. Humans. Infant. Occipital Bone / pathology. Occipital Bone / surgery. Temporal Bone / pathology. Temporal Bone / surgery

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  • (PMID = 17233317.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Yu H, Li H, Wang CF, Zhu XZ: [Low-grade central osteosarcoma: a clinicopathologic analysis of nine cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Nov;39(11):762-6
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  • OBJECTIVE: to study the clinicopathologic features and differential diagnosis of low-grade central osteosarcoma (LGCOS).
  • The tumors were treated by surgical excision, with no adjuvant therapy given.
  • Gross examination showed that the tumors were fragmented on submission in 5 cases and en bloc in 4 cases.
  • The spindly tumor cells showed mild degree of nuclear pleomorphism, with occasional mitotic figures demonstrated in all of the 9 cases.
  • The newly formed neoplastic woven bone did not have any osteoblastic rimming.
  • Parallel arrays of woven bone were seen in 6 cases.
  • The tumor cells permeated adjoining pre-existing bony trabeculae and bone marrow in all cases.
  • CONCLUSIONS: LGCOS often posses important diagnostic pitfalls due to the relatively bland-looking tumor cell morphology and associated large woven or longitudinal seams of lamellar-like bone.
  • Thorough understanding of the histologic features, when coupled with clinical and radiologic findings, are essential in arriving at a correct diagnosis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology. Thigh
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Fibrous Dysplasia of Bone / pathology. Fibula / radiography. Histiocytoma, Benign Fibrous / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Young Adult

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  • (PMID = 21215168.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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40. Zhang QH, Liu HS, Kong F: [Endoscopic endonasal surgery for tumors of petroclival region and infratemporal fossa]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Jul;40(7):488-92
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  • [Title] [Endoscopic endonasal surgery for tumors of petroclival region and infratemporal fossa].
  • This study was undertaken to determine whether endoscopic endonasal approach was safe and effective for the resection of tumors located in petroclival region and infratemporal fossa.
  • METHODS: Seventeen patients with tumors of petroclival region and infratemporal fossa treated by endoscopic endonasal surgery between January 2002 and February 2005 were studied prospectively.
  • RESULTS: Total tumor removal was obtained in 15 cases, subtotal removal in 2 case.
  • The other cases with benign tumors were no recurrence.
  • All of 5 cases with malignant tumors followed up for longer than 2 years were no recurrence and death.
  • CONCLUSIONS: The endoscopic endonasal surgery provides satisfied treatment for selected tumors of petroclival region and infratemporal fossa.
  • Using neuronavigation system, it is helpful to determining anatomical landmark and removing the tumor completely and securely.
  • [MeSH-major] Endoscopy / methods. Petrous Bone / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16200953.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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41. Utispan K, Thuwajit P, Abiko Y, Charngkaew K, Paupairoj A, Chau-in S, Thuwajit C: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker. Mol Cancer; 2010;9:13
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  • [Title] Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker.
  • Periostin (PN) is a multi-functional protein and has emerged as a promising marker for tumor progression.
  • Low to no expression of PN was observed in tissues of benign liver disease and hepatocellular carcinoma.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cell Line, Tumor. Cell Proliferation. Disease Progression. Gene Expression Regulation, Neoplastic. Gene Knockdown Techniques. Humans. Immunohistochemistry. Integrin alpha5 / metabolism. Liver / metabolism. Liver / pathology. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Neoplasm Invasiveness. Prognosis. Proportional Hazards Models. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20096135.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / Integrin alpha5; 0 / POSTN protein, human
  • [Other-IDs] NLM/ PMC2841583
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42. Cordeiro SZ, Cordeiro Pde B, Sousa AM, Lannes DC, Pierro GS: Giant cell tumor of the rib occupying the entire hemithorax. J Bras Pneumol; 2008 Mar;34(3):185-8
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  • [Title] Giant cell tumor of the rib occupying the entire hemithorax.
  • The authors report the case of a 28-year-old female patient with a giant cell tumor originating from the rib.
  • The tumor, measuring 25 x 17 cm, occupied the entire hemithorax and caused atelectasis of the left lung.
  • This tumor was a benign mesenchymal neoplasm, which rarely affects the ribs.
  • A thoracotomy involving en bloc resection of the chest wall and tumor was performed.
  • Despite the large dimensions of the tumor, complete resection was possible, and lung function was restored.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Ribs

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  • (PMID = 18392468.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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43. Hoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, Witzigmann H: Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol; 2007 Jan 14;13(2):257-63
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  • [Title] Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients.
  • AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas.
  • METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pancreatic benign surgical diseases (n = 15, control group) were included in the study.
  • Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed.
  • All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR.
  • In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage.
  • In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation.
  • CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3).
  • Pancreatic cancer patients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis.
  • CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocarcinoma by CK-19 fluorogenic RT-PCR.
  • In peritoneal lavage, detection rate is correlated with tumor stage and differentiation.
  • In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Pancreatic Ductal / diagnosis. Keratin-19 / genetics. Neoplastic Cells, Circulating / chemistry. Pancreatic Neoplasms / diagnosis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] Bone Marrow / pathology. Humans. Peritoneal Lavage. RNA, Messenger / analysis. RNA, Messenger / blood

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  • (PMID = 17226905.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / RNA, Messenger; 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ PMC4065954
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44. Camargo OP, Croci AT, Oliveira CR, Baptista AM, Caiero MT: Functional and radiographic evaluation of 214 aggressive benign bone lesions treated with curettage, cauterization, and cementation: 24 years of follow-up. Clinics (Sao Paulo); 2005 Dec;60(6):439-44
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  • [Title] Functional and radiographic evaluation of 214 aggressive benign bone lesions treated with curettage, cauterization, and cementation: 24 years of follow-up.
  • PURPOSE: Treatment with curettage, cauterization, and methylmethacrylate of aggressive benign bone lesions is a method now widely accepted in most orthopedic oncology centers.
  • However, one of the controversies regarding this technique is the possible complications that may arise from the use of methylmethacrylate, which has caused some authors to remove it 2 years after the surgery and replace it with bone graft.
  • The objective of this paper is to present a functional and radiographic evaluation of 214 patients presenting with aggressive benign bone lesions treated with curettage, cauterization, and methylmethacrylate from 1974 to 1998, with some of them having 24 years of follow-up.
  • All cases involved aggressive benign lesions.
  • The patients were evaluated according to the Musculoskeletal Tumor Society Score (MSTS) functional evaluation system, and the complications are described.
  • [MeSH-major] Bone Neoplasms / therapy. Cementation / adverse effects. Curettage. Giant Cell Tumors / therapy. Methylmethacrylate / adverse effects. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Bone Cements / adverse effects. Cautery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Treatment Outcome

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  • (PMID = 16358131.001).
  • [ISSN] 1807-5932
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Bone Cements; 196OC77688 / Methylmethacrylate
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45. Melamed E, Angel D: Myositis ossificans mimicking compartment syndrome of the forearm. Orthopedics; 2008 Dec;31(12)
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  • Myositis ossificans is a benign disorder of heterotopic bone formation occurring in response to soft tissue trauma.
  • Since there is frequently no significant history of injury, the lesion may be mistaken for a malignant bone or soft tissue tumor or infection.
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Forearm. Humans


46. Wang Z, Guo Z, Li J, Li XD, Sang HX: Functional outcomes and complications of reconstruction of the proximal humerus after intra-articular tumor resection. Orthop Surg; 2010 Feb;2(1):19-26
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  • [Title] Functional outcomes and complications of reconstruction of the proximal humerus after intra-articular tumor resection.
  • OBJECTIVE: To evaluate functional outcomes and complications of reconstruction of the proximal humerus after intra-articular tumor resection.
  • METHODS: Twenty-five patients who underwent Malawer I type resection and reconstruction of the proximal humerus for treatment of malignant or invasive benign tumors from August 1999 to August 2005 were evaluated.
  • A variety of reconstructive procedures, including modular tumor prosthesis, osteoarticular allograft, and allograft-prosthetic composite (APC), were performed after resection of tumor.
  • The modified Musculoskeletal Tumor Society (MSTS) evaluation system was used to assess limb functional outcome.
  • RESULTS: The study group consisted of 10 male and 15 female patients, among which there were 20 malignant and 5 benign tumors.
  • [MeSH-major] Arthroplasty, Replacement / methods. Bone Neoplasms / surgery. Humerus / surgery. Neoplasms, Connective Tissue / surgery. Shoulder Joint / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Lymphoma / mortality. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Postoperative Complications / epidemiology. Recovery of Function. Retrospective Studies. Treatment Outcome. Young Adult

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  • [Copyright] © 2010 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 22009903.001).
  • [ISSN] 1757-7861
  • [Journal-full-title] Orthopaedic surgery
  • [ISO-abbreviation] Orthop Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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47. Bonekamp D, Jacene H, Bartelt D, Aygun N: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med; 2008 Dec;33(12):909-11
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  • Fibrous dysplasia (FD) accounts for 7% of benign bone tumors.
  • It is a developmental disorder of unclear etiology.
  • The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue.
  • We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Molecular Mimicry. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Skull / pathology. Skull / radionuclide imaging

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  • (PMID = 19033807.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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48. Jeblaoui Y, Ben Neji N, Haddad S, Zribi A, Néji R, Boussafa H, Sahtout S, Hchicha S: [Mandibular aneurysmal bone cyst mimicking a malignant tumor]. Rev Stomatol Chir Maxillofac; 2007 Jun;108(3):238-40
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  • [Title] [Mandibular aneurysmal bone cyst mimicking a malignant tumor].
  • [Transliterated title] Kyste osseux anévrismal mandibulaire mimant une tumeur maligne.
  • MRI suggested a diagnosis of a rhabdomyosarcoma but CT-scan evoked a benign lesion such as chondroblastoma or aneurismal bone cyst.
  • The biopsy specimen proved the diagnosis of aneurismal bone cyst and the patient was treated by surgical curettage.
  • DISCUSSION: The aneurismal bone cyst of the jaw is a rare pseudocystic lesion, characterized by replacement of the normal bone with fibro-osseous tissue containing blood-filled sinusoidal or cavernous spaces.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Jaw Cysts / diagnosis. Mandibular Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Mandibular Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17445848.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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49. McPherson SJ, Hussain S, Balanathan P, Hedwards SL, Niranjan B, Grant M, Chandrasiri UP, Toivanen R, Wang Y, Taylor RA, Risbridger GP: Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated. Proc Natl Acad Sci U S A; 2010 Feb 16;107(7):3123-8
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  • [Title] Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated.
  • Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are androgen-dependent diseases commonly treated by inhibiting androgen action.
  • These data provide evidence of the beneficial effects of ERbeta agonist on epithelium and stroma of BPH, as well as androgen-independent tumor cells implicated in recurrent disease.
  • [MeSH-major] Apoptosis / physiology. Estrogen Receptor beta / metabolism. Hyperplasia / metabolism. Prostate / pathology. Prostatic Neoplasms / metabolism. Tumor Necrosis Factor-alpha / metabolism
  • [MeSH-minor] Analysis of Variance. Androgens / metabolism. Animals. Cell Line, Tumor. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Mice. Mice, Knockout

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  • (PMID = 20133657.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Estrogen Receptor beta; 0 / Tumor Necrosis Factor-alpha
  • [Other-IDs] NLM/ PMC2840300
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50. Kitsoulis P, Mantellos G, Vlychou M: Osteoid osteoma. Acta Orthop Belg; 2006 Apr;72(2):119-25
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  • Osteoid osteoma is a relatively frequent benign bone tumour, consisting of osteoid and woven bone, and surrounded by a halo of reactive sclerotic bone, with an average size of the nidus less than 1.5 cm.
  • [MeSH-major] Bone Neoplasms. Osteoma, Osteoid

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  • (PMID = 16768252.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 42
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51. Temple HT, Malinin TI: Microparticulate cortical allograft: an alternative to autograft in the treatment of osseous defects. Open Orthop J; 2008;2:91-6
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  • [Title] Microparticulate cortical allograft: an alternative to autograft in the treatment of osseous defects.
  • Benign bone tumors are commonly diagnosed and treated.
  • Following tumor removal, the defect in the bone can be filled with auto- or allografts, (degradable) bone substitutes or non-degradable polymethylmethacrylate.
  • The ideal substitute for this purpose should provide immediate structural support and readily incorporate into bone over a short period of time.
  • Using a combination of small allogeneic cortical graft particles (< 250 microm), bone defects were filled following intralesional excision in 97 consecutive patients with benign and low grade malignant tumors and tumor-like conditions of bone.
  • The clinical results and rate of radiographic incorporation and osseous consolidation were recorded and analyzed.
  • These patients underwent 104 procedures in which osseous defects were packed with microparticulate allograft.
  • There were eleven failures (10.6 %), eight (72 %) due to tumor recurrence.
  • Seven of eight patients with tumor recurrence underwent a second resection and grafting procedure that resulted in allograft incorporation and defect healing.
  • The use of small-particle cortical allograft proved to be an effective alternative to autogenous bone graft in patients with metaphyseal and metadiaphyseal surgical bone defects.

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  • (PMID = 19478936.001).
  • [ISSN] 1874-3250
  • [Journal-full-title] The open orthopaedics journal
  • [ISO-abbreviation] Open Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2687117
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52. Cai J, Kandagatla P, Singareddy R, Kropinski A, Sheng S, Cher ML, Chinni SR: Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells. Transl Oncol; 2010 Jun 01;3(3):195-203
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  • We and others have shown that chemokine receptor CXCR4 expression is upregulated in PC tumor cells, and its ligand, CXCL12, is expressed in bone stromal cells.
  • Results of the current study show that 1) prostate tumor cells coexpress higher ERG and CXCR4 compared with benign tissue, 2) CXCR4 expression is increased in the TMPRSS2-ERG fusion-positive cell line, 3) ERG transcription factor binds to the CXCR4 gene promoter, 4) synthetic androgen (R1881) upregulates both ERG and CXCR4 in TMPRSS2-ERG fusion-positive VCaP cells, 5) small interfering RNA-mediated down-regulation of ERG resulted in the loss of androgen-dependent regulation of CXCR4 expression in VCaP cells, and 6) R1881-activated TMPRSS2-ERG expression functionally activates CXCR4 in VCaP cells.
  • These findings provide a link between TMPRSS2-ERG translocations and enhanced metastasis of tumor cells through CXCR4 function in PC cells.

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  • (PMID = 20563261.001).
  • [ISSN] 1936-5233
  • [Journal-full-title] Translational oncology
  • [ISO-abbreviation] Transl Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA151557
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2887649
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53. Xing Y, Zhao JH, Wang TS, Qiao WL, Che WJ: [The role of 18F-FDG SPECT-CT in detecting recurrence and metastases in breast cancer patients with elevated tumor markers]. Zhonghua Zhong Liu Za Zhi; 2009 Feb;31(2):129-33
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  • [Title] [The role of 18F-FDG SPECT-CT in detecting recurrence and metastases in breast cancer patients with elevated tumor markers].
  • OBJECTIVE: To compare retrospectively the role of (18)F-FDG SPECT-CT and conventional imaging in the detection of recurrence and metastases in postoperative breast cancer patients with elevated level of tumor markers, and to evaluate the impact of (18)F-FDG SPECT-CT on the management of breast cancer patients.
  • METHODS: (18)F-FDG SPECT-CT was performed in 35 breast cancer patients with suspected recurrence based on elevated level of serum tumor markers.
  • Chest, abdomen and pelvic CT were performed in all patients and whole-body bone scan was performed in only 21 patients.
  • The final diagnosis of recurrent breast cancer was confirmed by either pathology or observation by imaging during the follow-up for more than 1 year.
  • RESULTS: Among the 35 patients, the final diagnosis of recurrence or metastasis was established in 19 patients.
  • Of the 114 sites of increased FDG uptake, 93 were interpreted as malignant and 21 as benign.
  • CONCLUSION: In postoperative breast cancer patients with elevated level of tumor markers during the follow-up, (18)F-FDG SPECT-CT is more sensitive for detecting recurrence and metastases than conventional imaging.
  • [MeSH-major] Breast Neoplasms / pathology. Fluorodeoxyglucose F18. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / blood. Breast Neoplasms, Male / blood. Breast Neoplasms, Male / pathology. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Radiopharmaceuticals. Retrospective Studies. Whole Body Imaging

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  • (PMID = 19538891.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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54. van de Luijtgaarden AC, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT: Metastatic potential of an aneurysmal bone cyst. Virchows Arch; 2009 Nov;455(5):455-9
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  • [Title] Metastatic potential of an aneurysmal bone cyst.
  • Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa.
  • Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient.
  • Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Bone Neoplasms / pathology. Neoplasms, Second Primary / pathology. Osteosarcoma / pathology. Proto-Oncogene Proteins / genetics. Ubiquitin Thiolesterase / genetics

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  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Proto-Oncogene Proteins; 2S9ZZM9Q9V / Bevacizumab; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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55. Boutayeb F, El Ibrahimi A, Chraibi F, Znati K: Leiomyoma in an index finger: report of case and review of literature. Hand (N Y); 2008 Sep;3(3):210-1
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  • Leiomyoma is a rare benign tumor of nonstriated muscles.
  • We report the diagnosis, prognosis, and therapeutic aspects of this tumor, with a literature review.

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  • (PMID = 18780097.001).
  • [ISSN] 1558-9447
  • [Journal-full-title] Hand (New York, N.Y.)
  • [ISO-abbreviation] Hand (N Y)
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56. Panasiuk M, Iwański A: Diagnostic difficulties in pigmented villonodular synovitis. Presentation of cases. Ortop Traumatol Rehabil; 2008 Nov-Dec;10(6):613-9
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  • In the literature, this condition has been called xanthoma, xanthogranuloma, villous arthritis, pigmented villonodular synovitis, xanthomatous giant cell tumour, giant cell tumour of tendon sheath, giant cell fibrohemangioma, benign synovioma.
  • [MeSH-major] Synovitis, Pigmented Villonodular / diagnosis. Synovitis, Pigmented Villonodular / surgery
  • [MeSH-minor] Adolescent. Ankle Joint. Diagnosis, Differential. Female. Giant Cell Tumor of Bone / diagnosis. Hemangioma / diagnosis. Humans. Knee Joint / blood supply. Magnetic Resonance Imaging. Middle Aged. Synovial Membrane / surgery. Terminology as Topic

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  • (PMID = 19153550.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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57. James SL, Davies AM: Giant-cell tumours of bone of the hand and wrist: a review of imaging findings and differential diagnoses. Eur Radiol; 2005 Sep;15(9):1855-66
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  • [Title] Giant-cell tumours of bone of the hand and wrist: a review of imaging findings and differential diagnoses.
  • Giant-cell tumour of bone (GCTOB) is a benign, locally aggressive, primary bone tumour.
  • The role of bone scintigraphy, computed tomography and magnetic resonance imaging is discussed.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carpal Bones / pathology. Diagnostic Imaging. Giant Cell Tumor of Bone / diagnosis. Hand Bones / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 15868123.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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58. Skubitz KM, Manivel JC: Giant cell tumor of the uterus: case report and response to chemotherapy. BMC Cancer; 2007;7:46
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  • [Title] Giant cell tumor of the uterus: case report and response to chemotherapy.
  • BACKGROUND: Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor.
  • The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Giant Cell Tumors / drug therapy. Uterine Neoplasms / drug therapy
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Antibiotics, Antineoplastic / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Agents, Alkylating / administration & dosage. Bevacizumab. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Hysterectomy. Ifosfamide / administration & dosage. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Middle Aged. Treatment Outcome

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  • (PMID = 17359524.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents, Alkylating; 2S9ZZM9Q9V / Bevacizumab; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 57
  • [Other-IDs] NLM/ PMC1832205
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59. Mukonoweshuro P, Oriowolo A: Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma. Gynecol Oncol; 2005 Oct;99(1):222-4
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  • [Title] Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma.
  • BACKGROUND: Stromal osseous metaplasia is a rare and curious finding in tumors of the ovary.
  • The tumor recurred 21 years later with prominent stromal osseous metaplasia that had not been present in the primary.
  • DISCUSSION: The pathogenesis of osseous metaplasia in epithelial tumors of the ovary is unclear; however, it is probable that a metaplastic process involving multipotential stromal stem cells results in bone formation.
  • CONCLUSION: Benign osseous metaplasia in ovarian tumors is rare and its histogenesis remains unclear.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Neoplasm Recurrence, Local / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 16023183.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Farzaneh AH, Pardis PM: Central giant cell granuloma and fibrous dysplasia occurring in the same jaw. Med Oral Patol Oral Cir Bucal; 2005;10 Suppl 2:E130-2
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  • Fibrous dysplasia (FD) is a developmental tumor like condition that is characterized by replacement of normal bone by an excessive proliferation of cellular fibrous connective tissue intermixed with irregular bony trabeculae.
  • Central giant cell granuloma (CGCG) is described as a benign lesion affecting the mandible and maxilla that consists of a massive fibrohistiocytic proliferation with numerous heavily hemosiderin-laden multinucleate-giant cells.
  • Our differential diagnosis was osteoma, osteoid osteoma and Fd.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Osteoma / diagnosis. Osteoma, Osteoid / diagnosis

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  • (PMID = 15995572.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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61. Cajaiba MM, Bale AE, Alvarez-Franco M, McNamara J, Reyes-Múgica M: Rhabdomyosarcoma, Wilms tumor, and deletion of the patched gene in Gorlin syndrome. Nat Clin Pract Oncol; 2006 Oct;3(10):575-80
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  • [Title] Rhabdomyosarcoma, Wilms tumor, and deletion of the patched gene in Gorlin syndrome.
  • The patient underwent surgical removal of both neoplasms, which were diagnosed as a rhabdomyosarcoma and a Wilms tumor.
  • Seven years later, she presented with macroglossia and a benign mandibular cyst.
  • DIAGNOSIS: Gorlin syndrome with synchronous rhabdomyosarcoma and Wilms tumor.
  • MANAGEMENT: Left nephrectomy, excision of paravesical tumor, excision of mandibular cysts, chemotherapy, and radiotherapy.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Kidney Neoplasms / surgery. Rhabdomyosarcoma / surgery. Wilms Tumor / surgery
  • [MeSH-minor] Bone Cysts / complications. Child, Preschool. Female. Humans. Macroglossia / etiology. Mandible. Receptors, Cell Surface / genetics

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  • (PMID = 17019435.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
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62. Hoberg M, Amstutz HC: Metal-on-metal hip resurfacing in patients with pigmented villonodular synovitis: a report of two cases. Orthopedics; 2010 Jan;33(1):50
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  • Pigmented villonodular synovitis (PVNS) of the hip joint is a rare and benign tumor of the synovia.
  • This local, aggressive, proliferative disorder of the joint synovial membrane can lead to secondary osteoarthritis and represents a small percentage of all patients undergoing total hip replacement (THR).
  • Because of the usually young age of the patients undergoing THR for PVNS, a resurfacing arthroplasty of the hip appears as a beneficial treatment option due to its bone-conserving nature, good joint stability, and ability to easily convert to a THR if needed.

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20055355.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
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63. Asilian A, Tamizifar B: Aggressive and neglected basal cell carcinoma. Dermatol Surg; 2005 Nov;31(11 Pt 1):1468-71
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  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy and usually has a benign coarse.
  • Rarely, examples of aggressive and neglected types of this tumor are seen.
  • OBJECTIVE: To present an interesting and dramatic example of how some people neglect their tumors and how devastating the sequelae can be.
  • He also had skull bone destruction, osteomyelitis, mastoiditis, cranial nerve paralysis, and radiographic features of the skull base and upper cervical soft tissue involvement.

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  • (PMID = 16416624.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Qamouss O, Zoubeir Y, Oukabli M, Chahdi H, Harket A, Abouchadi A, Nassih M, Albouzidi A, Rimani M, Labraimi A: [Ganglioneuroma of the zygoma]. Rev Stomatol Chir Maxillofac; 2006 Nov;107(5):370-2
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  • [Transliterated title] Le ganglioneurome de l'os zygomatique.
  • INTRODUCTION: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms.
  • The occurrence of ganglioneuroma in the bone is exceptional.
  • We discuss the possible causes of tumor development at this site.
  • [MeSH-major] Bone Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Zygoma / pathology

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  • (PMID = 17128189.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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65. Sponer P, Urban K, Urbanová E: [Scintigraphic detection of osteoblast activity after implantation of BAS-0 bioactive glass-ceramic material into long bone defects]. Acta Chir Orthop Traumatol Cech; 2006 Jun;73(3):176-82
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  • [Title] [Scintigraphic detection of osteoblast activity after implantation of BAS-0 bioactive glass-ceramic material into long bone defects].
  • PURPOSE OF THE STUDY: The aim of the study was to demonstrate, by three-phase bone scintigraphy, radionuclide uptake at the site of defects in long bones filled with the non-resorbable bioactive glass-ceramic material BAS-0 at a long follow-up.
  • MATERIAL: Twenty patients, 14 men and 6 women, operated on between 1990 and 2000 for benign bone tumors or tumor-like lesions localized in the femur, tibia or humerus were comprised in the study.
  • The diagnoses based on histological examination included juvenile bone cysts in 11, aneurysmal bone cyst in five, non-ossifying fibroma in two, and fibrous dysplasia in two patients.
  • Three-phase bone scans were made and the healthy and the affected limbs in each patient were compared by means of an index.
  • On three-phase bone scans, radionuclide distribution on the flow phase and soft tissue phase was symmetrical in both limbs of all patients.
  • This changes local mechanical signals, which has a negative effect on the adjacent bone tissue.
  • Stress accumulating at the interface of a rigid implant and bone tissue may result in pain, and is detected by scintigraphy as an increased nucleotide uptake, particularly in diaphyseal grafts.
  • [MeSH-major] Bone Diseases / therapy. Bone Substitutes. Bone and Bones / radionuclide imaging. Ceramics. Osseointegration. Prostheses and Implants

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  • (PMID = 16846563.001).
  • [ISSN] 0001-5415
  • [Journal-full-title] Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca
  • [ISO-abbreviation] Acta Chir Orthop Traumatol Cech
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / BAS O glass ceramic; 0 / Bone Substitutes
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66. Katthagen BD, Prub A: [Bone allografting]. Orthopade; 2008 Aug;37(8):764-71
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  • [Title] [Bone allografting].
  • [Transliterated title] Transplantation allogenen Knochens.
  • Bone allografts facilitate bone reconstruction in orthopedic surgery.
  • After implantation, bone allografts become necrotic but are incorporated and remodeled in the recipient bone with good regenerative capacity.
  • We use bone allografts in about 3% of all elective orthopedic operations in our hospital.
  • We use bone allografts regularly in acetabuloplasty in cases of severe residual hip dysplasia.
  • Bone allografts are most often used in revision total joint arthroplasty.
  • In cases of reconstruction of defects in benign bone tumors and tumor-like lesions, bone allografts are often suitable.
  • In fibrous dysplasia, corticocancellous bone allografts are even the treatment of choice.
  • [MeSH-major] Bone Transplantation / methods. Orthopedic Procedures
  • [MeSH-minor] Acetabulum / surgery. Adult. Arthroplasty, Replacement. Bone Banks. Bone Neoplasms / surgery. Bone Regeneration. Bone Remodeling / physiology. Child. Disinfection. Follow-Up Studies. Hip Dislocation, Congenital / surgery. Humans. Prosthesis Failure. Reoperation. Transplantation, Homologous

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  • (PMID = 18584151.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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67. Herneth AM, Friedrich K, Weidekamm C, Schibany N, Krestan C, Czerny C, Kainberger F: Diffusion weighted imaging of bone marrow pathologies. Eur J Radiol; 2005 Jul;55(1):74-83
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  • [Title] Diffusion weighted imaging of bone marrow pathologies.
  • Processes involving bone marrow where the primary target for DWI during the last years.
  • Most experience has been gained for differentiating benign from pathologic vertebral compression fractures, which can be reliably done when quantitative diffusion measurements are available.
  • Moreover, this will be the first non-invasive and quantifiable tool for evaluating the effectiveness of modern tumor treatment.
  • In this article, we will give an overview on the current status of DWI in the evaluation of bone marrow alterations; on currently available DWI techniques and a short out-look on future aspects of DWI in bone marrow pathologies.
  • [MeSH-major] Bone Marrow Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods
  • [MeSH-minor] Humans. Osteomyelitis / diagnosis. Sensitivity and Specificity. Spinal Fractures / diagnosis

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  • (PMID = 15921871.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 69
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68. Bruners P, Penzkofer T, Günther RW, Mahnken A: [Percutaneous radiofrequency ablation of osteoid osteomas: technique and results]. Rofo; 2009 Aug;181(8):740-7
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  • PURPOSE: Osteoid osteoma is a benign primary bone tumor that typically occurs in children and young adults.
  • Besides local pain, which is often worse at night, prompt relief due to medication with acetylsalicylic acid (ASS) is characteristic for this bone lesion.
  • MATERIALS AND METHODS: Using this technique, an often needle-shaped RF applicator is percutaneously placed into the tumor under image guidance.
  • Then a high-frequency alternating current is applied by the tip of the applicator which leads to ionic motion within the tissue resulting in local heat development and thus in thermal destruction of the surrounding tissue including the tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging / methods. Osteoma, Osteoid / surgery. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19517335.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 58
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69. Gösling T, Probst C, Länger F, Rosenthal H, Brunnemer U, Krettek C: [Diagnostics and treatment of primary bone tumors]. Chirurg; 2010 Jul;81(7):657-78; quiz 679-80
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  • [Title] [Diagnostics and treatment of primary bone tumors].
  • Primary bone tumors can be either benign or malignant.
  • Metastization is a characteristic feature of malignant bone tumors.
  • Malignant tumors are characterized by a local aggressive and destructive behavior.
  • The behavior of a tumor is dependent on its entity, the differentiation grade and localization and these factors are of decisive importance for the correct therapy.
  • Even benign tumors can behave very aggressively.
  • Many tumors show typical characteristics and if a malignant lesion is suspected a biopsy should be carried out.
  • The approach to malignant tumors is always interdisciplinary.
  • The treatment of primary malignant bone tumors requires a lot of experience and should only be done in specialized centers.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biopsy. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Bone and Bones / pathology. Bone and Bones / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Staging. Radionuclide Imaging. Sensitivity and Specificity. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20512557.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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70. Wang V, Chou D: Anterior C1-2 osteochondroma presenting with dysphagia and sleep apnea. J Clin Neurosci; 2009 Apr;16(4):581-2
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  • Spinal osteochondromas are rare, benign tumors of the bone.
  • These tumors can manifest as solitary lesions or as part of a hereditary syndrome.
  • The patient underwent resection of the tumor via a left anterior transcervical approach to the spine.


71. García-Reyna JC, Rico Martínez G, Vega González IF, Linares LM, Delgado Cedillo EA, Romero Ramírez R: [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin]. Acta Ortop Mex; 2008 Nov-Dec;22(6):390-6
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  • [Title] [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin].
  • [Transliterated title] 99mTc-Tetrofosmin en la evaluación de tumores musculoesqueléticos.
  • INTRODUCTION: (99m)Tc-tetrofosmin is an efficient agent as a tumor marker.
  • Several studies have proven its efficiency in detection and localization of tumors of the breast, larynx, thyroid, parathyroid glands, lung, brain, skin, lymphatic and musculoskeletal tissues with a sensitivity and specificity of 95% to 100%.
  • Nevertheless, benign pathology such as active inflammation is a source of false positives and the attending physician must consider the aid of complementary studies such as histopathology.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Muscle Neoplasms / radionuclide imaging. Organophosphorus Compounds. Organotechnetium Compounds. Radiopharmaceuticals

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  • (PMID = 19280840.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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72. Sbai MA, Hamdi MF, Aloui I, Zalouni I, Tabib M: [Soft tissue chondroma of the thumb. A case report]. Tunis Med; 2010 Oct;88(10):750-2
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  • [Transliterated title] Le chondrome des parties molles du pouce. A propos d'un cas.
  • BACKGROUND: Soft-tissue chondroma is a rare and benign cartilaginous tumour often localised in the extremities.
  • CASE REPORT: 43 year-old man presented with soft tissue tumour of the left thumb for about 4 years without any symptoms.
  • Radiographs of the thumb showed a calcification out of the bone.
  • Surgery resection of the tumour was complete and easy.
  • Histological examination confirmed the diagnosis of soft-tissue chondroma.
  • CONCLUSION: Soft tissue chondroma is not a diagnosis evoked when we have a soft tissue tumor of the hand.
  • Diagnosis is confirmed by pathology which should eliminate a low grade chondrosarcoma.
  • [MeSH-major] Chondroma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thumb

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  • (PMID = 20890825.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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73. Sinici E, Tunay S, Kiliç E, Erler K, Altinmakas M: [Psychological evaluation of patients with benign musculoskeletal system tumors]. Acta Orthop Traumatol Turc; 2006;40(3):199-201
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  • [Title] [Psychological evaluation of patients with benign musculoskeletal system tumors].
  • [Transliterated title] Benign kas-iskelet sistemi tümörü olan hastalarda psikolojik durum değerlendirmesi.
  • OBJECTIVES: This study was designed to determine to what extent psychological status was affected by sociodemographic characteristics and by being informed about the diagnosis in patients with benign musculoskeletal tumors.
  • METHODS: The study included 112 male patients (mean age 23.8 years; range 20 to 35 years) who were hospitalized for benign tumors of the musculoskeletal system.
  • A questionnaire was administered to all the patients concerning their sociodemographic characteristics and the status of their knowledge about the diagnosis.
  • RESULTS: The depression level was not correlated with the localization (upper or lower extremity) of the musculoskeletal system tumor, the marital status of the patient, and the presence or absence of knowledge of the patient about the diagnosis (p>0.05).
  • [MeSH-major] Anxiety Disorders. Bone Neoplasms / psychology. Muscle Neoplasms / psychology

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  • (PMID = 16905891.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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74. Riopel C, Michot C: [Chordomas]. Ann Pathol; 2007 Feb;27(1):6-15
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  • Chordoma is a rare bone tumor, believed to derive from notochordal rests, which generally arises at the two extremities of axial skeleton.
  • Diagnosis has been greatly improved by MRI and immunohistochemistry.
  • The recognition of new entities such as giant notochordal rest or hamartoma, and notochordal cells benign tumor, can lead to confusion since there is no consensus regarding their nature and whether or not they correspond to chordoma precursors.
  • [MeSH-major] Bone Neoplasms / pathology. Chordoma / pathology

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  • [CommentIn] Ann Pathol. 2007 Oct;27(5):389 [18185479.001]
  • (PMID = 17568354.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 53
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75. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW Jr: Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett; 2009 Sep 28;283(1):29-35
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  • We have recently shown that PCa cell lines and primary prostate tumors express CXCR5, which correlates with PCa grade.
  • In this study, we present the first evidence that CXCL13, the only ligand for CXCR5, and IL-6 were significantly elevated in PCa patient serum compared to serum from subjects with benign prostatic hyperplasia (BPH), or high-grade prostatic intraepithelial neoplasia (HGPIN) as well as normal healthy donors (NHD).
  • CXCL13 was highly expressed by human bone marrow endothelial (HBME) cells and osteoblasts (OBs), but not osteoclasts (OCs), following treatment with physiologically relevant levels of interleukin-6 (IL-6).

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  • (PMID = 19375853.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / G12 RR003034-27; United States / NCRR NIH HHS / RR / G12 RR003034-23; United States / NCRR NIH HHS / RR / G12 RR003034; United States / NCI NIH HHS / CA / U24 CA086359-10; United States / NIMHD NIH HHS / MD / P60 MD000525-03; United States / NIMHD NIH HHS / MD / MD00525; United States / NIMHD NIH HHS / MD / P60 MD000525; United States / NIAID NIH HHS / AI / AI057808; United States / NCRR NIH HHS / RR / RR003034-23; United States / NIGMS NIH HHS / GM / S06 GM008248; United States / NIGMS NIH HHS / GM / GM09248; United States / NCRR NIH HHS / RR / RR03034; United States / NIGMS NIH HHS / GM / GM008248-22; United States / NIAID NIH HHS / AI / R01 AI057808; United States / NIDDK NIH HHS / DK / DK58967; United States / NCI NIH HHS / CA / U24CA86359.; United States / NCI NIH HHS / CA / U24 CA086359; United States / NIGMS NIH HHS / GM / GM08248; United States / NIGMS NIH HHS / GM / S06 GM008248-22; United States / NCI NIH HHS / CA / U56 CA092078; United States / NCI NIH HHS / CA / CA086359-10; United States / NCI NIH HHS / CA / CA092078
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCL13 protein, human; 0 / CXCR5 protein, human; 0 / Chemokine CXCL13; 0 / Integrins; 0 / Interleukin-6; 0 / Receptors, CXCR5; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ NIHMS140687; NLM/ PMC3600557
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76. Nissan A, Jager D, Roystacher M, Prus D, Peretz T, Eisenberg I, Freund HR, Scanlan M, Ritter G, Old LJ, Mitrani-Rosenbaum S: Multimarker RT-PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients. Br J Cancer; 2006 Mar 13;94(5):681-5
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  • RNA was extracted from 30 sentinel lymph nodes (SLN) obtained from 28 patients, three primary breast cancers (positive controls), three lymph nodes from patients with benign diseases, and peripheral blood lymphocytes of 10 healthy volunteers (negative controls).
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Case-Control Studies. DNA Primers. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis. Neoplasm Staging / methods. Neoplasm, Residual. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 16495929.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Primers
  • [Other-IDs] NLM/ PMC2361196
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77. Shi X, Wu S, Zhao J: [Limb salvage with osteoarticular allografts after resection of proximal tibia bone]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Oct;20(10):966-9
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  • [Title] [Limb salvage with osteoarticular allografts after resection of proximal tibia bone].
  • METHODS: From 1998 to 2003, 15 patients (7 males, 8 females; aged 14-56 yr. average 33) with bone tumor of the proximal tibia underwent osteoarticular allografts. among whom 7 had progressive giant cell tumor without any previous chemotherapy; 8 had malignant tumor with previous chemotherapy, including 6 patients with osteosarcoma, 1 with spindle cell sarcoma, and 1 with malignant fibrous histiocytoma.
  • RESULTS: The follow-up for an average of 21 months (range, 3-58 months) revealed that among the 8 patients with malignant tumor of the proximal tibia undergoing chemotherapy, 5 had union of the bone, 3 had no union of the bone; among the 3 patients, 2 had a complication of infection and 1 had a local recurrence.
  • Among the 7 patients with progressive giant cell tumor at the upper part of the tibia, none had infection or local recurrence, but 2 had nonunion of the bone and 2 had joint instability, aided by the knee-aiding system.
  • CONCLUSION: The osteoarticular allograft of the proximal tibia has many advantages in spite of a relatively high rate of complications, and it is the limb salvage of choice for the progressive benign or malignant bone tumors of the proximal tibia.
  • [MeSH-major] Bone Neoplasms / surgery. Limb Salvage / methods. Osteosarcoma / surgery. Tibia
  • [MeSH-minor] Adolescent. Adult. Bone Transplantation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Transplantation, Homologous. Treatment Outcome

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  • (PMID = 17140064.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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78. Metser U, Even-Sapir E: Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT. Semin Nucl Med; 2007 May;37(3):206-22
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  • [Title] Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT.
  • The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) in the field of oncology is rapidly evolving; however, (18)F-FDG is not tumor specific.
  • Aside from physiological uptake (18)F-FDG also may accumulate in benign processes.
  • Through the systematic review of the reports of PET/computed tomography (CT) studies performed in oncologic patients during a 6-month period, we found benign nonphysiological uptake of (18)F-FDG in more than 25% of studies.
  • A total of 73% of benign lesions were inflammatory in nature, with post-traumatic bone and soft-tissue abnormalities (including iatrogenic injury) and benign tumors accounting for the remainder.
  • The differentiation of benign from malignant uptake of (18)F-FDG on PET alone may be particularly challenging as a result of the low anatomical resolution of PET and paucity of anatomical landmarks.
  • We have tabulated our experience with benign entities associated with increased (18)F-FDG uptake on whole-body PET/CT from 12,000 whole-body (18)F-FDG-PET/CT studies performed during a 4-year period.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Inflammation / diagnosis. Inflammation / metabolism

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  • (PMID = 17418153.001).
  • [ISSN] 0001-2998
  • [Journal-full-title] Seminars in nuclear medicine
  • [ISO-abbreviation] Semin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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79. Behzatoğlu K, Durak H, Canberk S, Aydin O, Huq GE, Oznur M, Ozyalvaçli G, Yildiz P: Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma? Diagn Pathol; 2009;4:48
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  • [Title] Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
  • Giant cell tumor, excluding its prototype in bone, is usually a benign but local aggressive neoplasm originating from tendon sheath or soft tissue.
  • Giant cell tumors in visceral organs usually accompany epithelial tumors and the clinical behavior of giant cell tumor in urinary bladder is similar to its bone counterpart.
  • Here, we report two cases of giant cell tumor located in urinary bladder in comparison with nine reported cases in the English literature.
  • One of the two cases we present had no concurrent urothelial tumor at the time of diagnosis but had a history of a low grade noninvasive urothelial carcinoma with three recurrences.
  • The histology of these two cases was similar to the giant cell tumor of bone and composed of oval to spindle mononuclear cells with evenly spaced osteoclast-like giant cells.
  • The histologic and immunohistochemical properties in our cases as well as their clinical courses were consistent with a giant cell tumor.
  • Consequently, tumors in urinary bladder showing features of giant cell tumor of bone may also be considered and termed "giant cell tumor".

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  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
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80. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that typically is seen within the cortex of the tibia in children.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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81. Leto G, Incorvaia L, Badalamenti G, Tumminello FM, Gebbia N, Flandina C, Crescimanno M, Rini G: Activin A circulating levels in patients with bone metastasis from breast or prostate cancer. Clin Exp Metastasis; 2006;23(2):117-22
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  • [Title] Activin A circulating levels in patients with bone metastasis from breast or prostate cancer.
  • Therefore, we have investigated the clinical significance of its circulating levels in patients with bone metastasis.
  • Activin A serum concentrations were determined, by a commercially available enzyme-linked immunosorbent assay kit, in 72 patients with breast cancer (BC) or prostatic cancer (PC) with (BM+) or without (BM-) bone metastases, in 15 female patients with age-related osteoporosis (OP), in 20 patients with benign prostatic hypertrophy (BPH) and in 48 registered healthy blood donors (HS) of both sex (25 female and 23 male).
  • In BC patients, a significant correlation was observed only between Activin A and number of bone metastases (P = 0.0065) while, in PC patients, Activin A levels were strongly correlated with the Gleason score (P = 0.011) or PSA levels (P = 0.0001) and, to a lessen extent, with the number of bone metastases (P = 0.056).
  • These findings indicate that Activin A may be implicated in the pathogenesis of bone metastasis.
  • Therefore, this cytokine may be considered a novel potential target for a more selective therapeutic approach in the treatment of skeletal metastasis and may be also useful as additional biochemical marker of metastatic bone disease.
  • [MeSH-major] Activins / blood. Bone Neoplasms / secondary. Breast Neoplasms / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Female. Humans. Male. Middle Aged. Osteoporosis / blood. Prostatic Hyperplasia / blood. Sensitivity and Specificity


82. Hameed MR, Blacksin M, Das K, Patterson F, Benevenia J, Aisner S: Cortical chondroblastoma: report of a case and literature review of this lesion reported in unusual locations. Skeletal Radiol; 2006 May;35(5):295-7
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  • Chondroblastoma is a rare benign tumor occurring in adolescence and young adulthood, almost always involving the epiphysis of long bones.
  • Biopsy revealed a chondroblastoma, and the patient subsequently underwent a total curettage of the lesion with cancellous bone graft from the iliac crest.
  • [MeSH-major] Chondroblastoma / diagnosis. Femoral Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Rare Diseases / diagnosis

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  • (PMID = 16501973.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
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  • [Number-of-references] 12
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83. Ho L, Stojanovski A, Whetstone H, Wei QX, Mau E, Wunder JS, Alman B: Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell; 2009 Aug 4;16(2):126-36
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  • [Title] Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
  • Clinical evidence suggests that benign cartilage lesions can progress to malignant chondrosarcoma, but the molecular events in this progression are unknown.
  • Mice that develop benign cartilage lesions due to overexpression of Gli2 in chondrocytes developed lesions similar to chondrosarcomas when they were also deficient in p53.
  • Treatment of human chondrosarcomas or fetal mouse limb explants with IGFBP3 or by blocking IGF increased the apoptosis rate, and mice expressing Gli2 developed substantially fewer tumors when they were also deficient for Igf2.
  • [MeSH-major] Apoptosis / genetics. Bone Neoplasms / pathology. Chondrocytes / pathology. Chondrosarcoma / pathology. Insulin-Like Growth Factor Binding Protein 3 / physiology. Kruppel-Like Transcription Factors / physiology. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 19647223.001).
  • [ISSN] 1878-3686
  • [Journal-full-title] Cancer cell
  • [ISO-abbreviation] Cancer Cell
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE15118
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type X; 0 / Gli2 protein; 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Kruppel-Like Transcription Factors; 0 / Somatomedins; 0 / Tumor Suppressor Protein p53
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84. Bellini A, Mattoli S: The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest; 2007 Sep;87(9):858-70
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  • [Title] The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses.
  • They likely represent the obligate intermediate stage of differentiation into mature mesenchymal cells of a bone marrow-derived precursor of the monocyte lineage under permissive conditions.
  • Similar cells also populate the stroma surrounding human benign tumors.
  • The available data indicate that human fibrocytes serve as a source of mature mesenchymal cells during reparative processes and in fibrotic disorders or stromal reactions predominantly associated with a persistent inflammatory infiltrate or with the selective recruitment of monocytes induced by ischemic changes and tumor development.
  • A deeper understanding of the mechanisms involved in fibrocyte differentiation in these pathological conditions may lead to the development of novel therapies for preventing detrimental tissue or vascular remodeling and metastatic progression of invasive tumors.

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  • (PMID = 17607298.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 128
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85. Westin G, Björklund P, Akerström G: Molecular genetics of parathyroid disease. World J Surg; 2009 Nov;33(11):2224-33
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  • BACKGROUND: Primary hyperparathyroidism (HPT) is often caused by a benign parathyroid tumor, adenoma; less commonly by multiglandular parathyroid disease/hyperplasia; and rarely by parathyroid carcinoma.
  • Patients with multiple tumors require wider exploration to avoid recurrence and have increased risk for hereditary disease.
  • Improved knowledge of the molecular background of parathyroid tumor development may help select patients for appropriate surgical treatment and can eventually provide new means of treatment.
  • Aberrant regulation of Wnt/beta-catenin signaling may be important for parathyroid tumor development.
  • CONCLUSIONS: Molecular genetic studies of parathyroid tumors are well designed basic experimental studies providing strong level III evidence, with data frequently confirmed by subsequent studies.

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  • (PMID = 19373510.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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86. Harzallah L, Bouajina E, Rammeh N, Belhadj SK, Ghannouchi M, Kraiem C: [Iliac chondroma: a case report]. Tunis Med; 2005 Sep;83(9):578-80
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  • Chondroma is a benign bone tumour that usually occurs in the in carpal and phalangeal bones.
  • The diagnosis of chondroma was confirmed after surgical biopsy.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroma / pathology. Ilium / pathology

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  • (PMID = 16383207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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87. Ozan F, Toker G: Secondary aneurysmal bone cyst of the patella. Acta Orthop Traumatol Turc; 2010;44(3):246-9
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  • [Title] Secondary aneurysmal bone cyst of the patella.
  • Aneurysmal bone cyst accounts for 1% of primary bone tumors and is one of the benign tumor-like lesions.
  • Its development on the basis of any previous lesion such as chondroblastoma is called secondary aneurysmal bone cyst.
  • Radiological studies were suggestive of an aneurysmal bone cyst.
  • At surgery, the cystic lesion was removed via curettage and the residual cavity was filled with an autogenous bone graft taken from the iliac wing.
  • The histopathologic diagnosis was secondary aneurysmal bone cyst in association with chondroblastoma.
  • [MeSH-major] Bone Cysts, Aneurysmal / radiography. Bone Neoplasms / complications. Chondroblastoma / complications. Patella
  • [MeSH-minor] Adult. Bone Transplantation. Curettage. Humans. Ilium / transplantation. Male

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  • (PMID = 21088467.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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88. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7
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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Kuroda K, Tajima S: Proliferation of HSP47-positive skin fibroblasts in dermatofibroma. J Cutan Pathol; 2008 Jan;35(1):21-6
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  • CONCLUSIONS: Skin fibroblast is one of the major constituent cells in DF, and DF may be composed chiefly of two types of cell lineages, fibroblasts and bone marrow-derived monocyte/macrophages (dermal dendritic cells and/or histiocytes).
  • [MeSH-major] Fibroblasts / metabolism. HSP47 Heat-Shock Proteins / metabolism. Histiocytoma, Benign Fibrous / metabolism. Skin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers, Tumor / metabolism. Cell Count. Cell Lineage. Cell Nucleus / pathology. Cell Proliferation. Dendritic Cells / metabolism. Dendritic Cells / pathology. Factor XIIIa / metabolism. Female. Giant Cells / metabolism. Giant Cells / pathology. Histiocytes / metabolism. Histiocytes / pathology. Humans. Male

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  • (PMID = 18095990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / HSP47 Heat-Shock Proteins; 0 / SERPINH1 protein, human; EC 2.3.2.13 / Factor XIIIa
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90. Budny AM, Ismail A, Osher L: Chondromyxoid fibroma. J Foot Ankle Surg; 2008 Mar-Apr;47(2):153-9
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  • Chondromyxoid fibroma is an uncommon benign cartilaginous tumor accounting for less than 1% of all bone tumors.
  • Early detection and complete surgical resection are valuable in preventing recurrence in the affected bone.
  • [MeSH-major] Chondroma / diagnosis. Fibroma / diagnosis. Foot Diseases / diagnosis

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  • (PMID = 18312923.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Kornaat PR, Camerlinck M, Vanhoenacker FM, De Praeter G, Kroon HM: Brodie's abscess revisited. JBR-BTR; 2010 Mar-Apr;93(2):81-6
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  • Radiology plays an important role in the diagnosis of a Brodie's abscess, as can be difficult for a clinician to identify the disease using clinical information alone.
  • Furthermore, a Brodie's abscess may mimic various benign and malignant conditions, resulting in delayed diagnosis and treatment.
  • The most frequently made incorrect diagnosis is that of a primary bone tumor.
  • The present pictorial review summarizes imaging clues to the diagnosis of a Brodie's abscess, such as the serpentine sign on conventional radiographs and the penumbra sign seen on Magnetic Resonance (MR) images.
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging / methods

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  • (PMID = 20524516.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 12
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92. Beaufour A, Cazals-Hatem D, Regimbeau JM, Ponsot P, Degott C, Belghiti J, Sauvanet A: [Osteoclastic giant cell tumour of the pancreas]. Gastroenterol Clin Biol; 2005 Feb;29(2):197-200
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  • [Title] [Osteoclastic giant cell tumour of the pancreas].
  • [Transliterated title] Tumeur à cellules géantes ostéoclastiques du pancréas.
  • Osteoclast giant cell tumours are bone tumours that occur in adults, and that are considered benign by WHO but locally aggressive.
  • Strictly identical tumours are described in the pancreas, without simultaneous bone localization.
  • We report the case of a 62-year woman with an osteoclast giant cell tumour of the distal pancreas, without any epithelial component, which was diagnosed after pancreatic resection and with no signs of recurrence after a 24-month follow-up.
  • These pancreatic tumours are rare, with a very poor prognosis, an unclear histogenesis; they are often confused with pleomorphic or undifferentiated pancreatic carcinomas including a component of osteoclast giant cell.
  • These osteoclast giant cell tumours of the pancreas usually present as large cystic tumours.
  • [MeSH-major] Giant Cell Tumor of Bone. Pancreatic Neoplasms

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  • (PMID = 15795672.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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93. Bahnassy M, Abdul-Khalik H: Soft tissue chondroma: a case report and literature review. Oman Med J; 2009 Oct;24(4):296-9
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  • Extra skeletal soft tissue chondroma is a very rare, slow progressing, benign tumor.

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  • (PMID = 22216384.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3243868
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94. Mäkitie AA, Törnwall J, Mäkitie O: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol; 2008 Jun;27(6):809-12
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  • Fibrous dysplasia (FD) is a benign skeletal disorder which may affect one or multiple bones.
  • She presented with a tumor-like lesion of the mandible.
  • Treatment with bisphosphonate administered intravenously resulted in rapid pain relief, normalization of bone turnover, and cosmetic improvement.
  • [MeSH-major] Bone Density Conservation Agents / therapeutic use. Diphosphonates / therapeutic use. Fibrous Dysplasia of Bone / diagnostic imaging. Fibrous Dysplasia of Bone / drug therapy. Mandible / diagnostic imaging
  • [MeSH-minor] Bone Density / drug effects. Child. Female. Humans. Radionuclide Imaging

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  • (PMID = 18247080.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
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95. Samdani A, Torre-Healy A, Chou D, Cahill AM, Storm PB: Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J; 2009 Jul;18 Suppl 2:196-200
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  • Osteoblastoma is a rare benign bone tumor that presents with back pain and occurs in the spine approximately 40% of the time.
  • The time from onset of symptoms to diagnosis is typically several months because it is a rare entity and radiographic studies are often negative early in the course of the disease.
  • These highly vascular and locally aggressive tumors require complete and precise resection.
  • He subsequently underwent piecemeal tumor resection and instrumented fusion.

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  • (PMID = 18839223.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2899567
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96. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • These usually metastasize to the lung, pleura, bone, and liver.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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97. Sidani CA, Karam AR, Bruce JH, Sklar E: Osteoblastoma of the frontal sinuses presenting with headache and blurred vision: case report and review of the literature. J Radiol Case Rep; 2010;4(6):1-7
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  • Osteoblastoma is a rare benign bone tumor that usually arises in the vertebral column and long bones of young adults.

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  • (PMID = 22470734.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303412
  • [Keywords] NOTNLM ; Frontal sinus / exophthalmos / osteoblastoma
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98. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj-Hassouni N: Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine; 2005 Mar;72(2):177-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma, or exostosis, is the most common of all benign bone tumors.

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  • (PMID = 15797501.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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99. Toy PC, France J, Randall RL, Neel MD, Shorr RI, Heck RK: Reconstruction of noncontained distal femoral defects with polymethylmethacrylate and crossed-screw augmentation: a biomechanical study. J Bone Joint Surg Am; 2006 Jan;88(1):171-8
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  • BACKGROUND: Curettage and cementation with polymethylmethacrylate are frequently used in the treatment of aggressive benign bone lesions such as giant-cell tumors, but strength and stiffness of the reconstructed bone have been concerns.
  • CONCLUSIONS: In this in vitro cadaver study, augmentation of polymethylmethacrylate cement with crossed screws resulted in a stronger reconstruction of distal femoral tumor defects than that obtained with cement alone or with cement and intramedullary Steinmann pins.
  • [MeSH-major] Bone Cements / therapeutic use. Bone Neoplasms / surgery. Bone Screws. Femur / surgery. Polymethyl Methacrylate / therapeutic use. Reconstructive Surgical Procedures
  • [MeSH-minor] Aged. Biomechanical Phenomena. Bone Nails. Cadaver. Case-Control Studies. Curettage. Elasticity. Femoral Fractures / classification. Femoral Fractures / physiopathology. Humans. Weight-Bearing / physiology

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  • (PMID = 16391262.001).
  • [ISSN] 0021-9355
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements; 9011-14-7 / Polymethyl Methacrylate
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100. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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