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1. Kodama S, Okamoto T, Suzuki M: Sinonasal schwannoma with new bone formation expressing bone morphogenic protein. Int J Otolaryngol; 2010;2010:154948
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sinonasal schwannoma with new bone formation expressing bone morphogenic protein.
  • Schwannoma is a benign tumor that arises from the sheath of myelinated nerve fibers and may occur in any part of the body.
  • Osteogenesis in schwannoma is extremely rare and, to date, new bone formation in sinonasal schwannoma has not yet been reported.
  • Here, we describe the first reported case of sinonasal schwannoma with new bone formation.
  • Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.

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  • (PMID = 21197441.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3010644
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2. Nawabi DH, Sinisi M: Schwannoma of the posterior tibial nerve: the problem of delay in diagnosis. J Bone Joint Surg Br; 2007 Jun;89(6):814-6
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  • [Title] Schwannoma of the posterior tibial nerve: the problem of delay in diagnosis.
  • The clinical diagnosis is usually straightforward, but may be delayed for many years in a schwannoma of the posterior tibial nerve.
  • We describe 25 patients with a schwannoma of the posterior tibial nerve.
  • In patients with a long history of neuropathic pain in the lower limb in whom lumbar and pelvic lesions have been excluded, a benign tumour of the sheath of a peripheral nerve may explain the symptoms.
  • [MeSH-major] Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Tibial Nerve

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  • (PMID = 17613510.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Jung SH, Jung S, Moon KS, Park HW, Kang SS: Tailored surgical approaches for benign craniovertebral junction tumors. J Korean Neurosurg Soc; 2010 Aug;48(2):139-44
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  • [Title] Tailored surgical approaches for benign craniovertebral junction tumors.
  • OBJECTIVE: We report our surgical experience in the treatment of 16 consecutive patients with benign craniovertebral junction (CVJ) tumor, observed from 2003 to 2008 at our department.
  • METHODS: We had treated 6 foramen magnum meningiomas, 6 cervicomedullary hemangioblastomas, 1 accessory nerve schwannoma, 1 hypoglossal nerve schwannoma, 1 C2 root schwannoma, and 1 cavernous hemangioma.
  • CONCLUSION: : The choice of surgical approaches and the extent of bone resection should be defined according to the location and size of individual tumors.

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  • (PMID = 20856663.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941857
  • [Keywords] NOTNLM ; Benign tumor / Complication / Craniovertebral junction / Neuroradiology / Surgical resection
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4. Ilgenfritz RM, Jones KB, Lueck N, Buckwalter JA: Intraosseous neurilemmoma involving the distal tibia and fibula: a case report. Iowa Orthop J; 2006;26:138-43
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  • [Title] Intraosseous neurilemmoma involving the distal tibia and fibula: a case report.
  • Schwannoma, or neurilemmoma, is a benign nerve sheath tumor most commonly located in the soft tissue.
  • We present the case of a neurilemmoma affecting both the distal fibula and tibia.
  • Although rare, intraosseous neurilemmoma should be included on the differential diagnosis of painful, radiographically benign-appearing lesions arising in long bones.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibula. Neurilemmoma / diagnosis. Tibia

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  • (PMID = 16789465.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1888578
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5. Ang WM, Yates P, Robbins P, Wood D: Recurrent benign solitary intraosseous schwannoma of the tibia. Orthopedics; 2008 Feb;31(2):176
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  • [Title] Recurrent benign solitary intraosseous schwannoma of the tibia.
  • Schwannomas (neurilemmomas) are benign neoplasms composed of well-differentiated Schwann cells and are usually found in the soft tissues.
  • The occurrence of schwannomas in bone is rare, accounting for less than 0.2% of primary bone tumors.
  • Most cases of osseous schwannoma reported in the world medical literature involve bones of the skull.
  • We report the first case of a recurrent benign solitary intraosseous schwannoma of the tibia, and detail the clinical, radiological and histological findings.
  • [MeSH-major] Bone Neoplasms / radiography. Bone Neoplasms / surgery. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Neurilemmoma / radiography. Neurilemmoma / surgery. Tibia / surgery

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  • (PMID = 19292192.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Kirschner LS, Kusewitt DF, Matyakhina L, Towns WH 2nd, Carney JA, Westphal H, Stratakis CA: A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res; 2005 Jun 1;65(11):4506-14
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  • Prkar1a(+/-) mice developed nonpigmented schwannomas and fibro-osseous bone lesions beginning at approximately 6 months of age.
  • Although genotype-specific cardiac and adrenal lesions were not seen, benign and malignant thyroid neoplasias were observed in older mice.
  • These observations confirm the identity of PRKAR1A as a tumor suppressor gene with specific importance to cyclic AMP-responsive tissues and suggest that these mice may be valuable tools not only for understanding endocrine tumorigenesis but also for understanding inherited predispositions for schwannoma formation.
  • [MeSH-major] Cyclic AMP / physiology. Disease Models, Animal. Multiple Endocrine Neoplasia / genetics. Neurilemmoma / genetics. Proteins / genetics
  • [MeSH-minor] Alleles. Animals. Bone Neoplasms / enzymology. Bone Neoplasms / genetics. Bone Neoplasms / pathology. Cyclic AMP-Dependent Protein Kinase RIalpha Subunit. Female. Genes, Tumor Suppressor. Genetic Predisposition to Disease. Male. Mice. Osteoblasts / cytology. Osteoblasts / physiology. Schwann Cells / cytology. Schwann Cells / physiology. Syndrome. Thymus Gland / cytology. Thymus Gland / physiology. Thyroid Neoplasms / enzymology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 15930266.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16058; United States / NICHD NIH HHS / HD / HD01323
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / Prkar1a protein, mouse; 0 / Proteins; E0399OZS9N / Cyclic AMP
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7. Choudry Q, Younis F, Smith RB: Intraosseous schwannoma of D12 thoracic vertebra: diagnosis and surgical management with 5-year follow-up. Eur Spine J; 2007 Dec;16 Suppl 3:283-6
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  • [Title] Intraosseous schwannoma of D12 thoracic vertebra: diagnosis and surgical management with 5-year follow-up.
  • Intraosseous schwannomas or neurilemomas are rare benign neoplasms that account for less than 0.2% of primary bone tumours.
  • Surgical decompression, excision and stabilisation with an extendable cage, bone graft and anterior rod system were achieved through a thoracolumbar approach.
  • Histology results confirmed an intraosseous schwannoma with no remnants of an originating nerve.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 17082954.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2148077
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8. Dobashi Y, Suzuki S, Sato E, Hamada Y, Yanagawa T, Ooi A: EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors. Mod Pathol; 2009 Oct;22(10):1328-40
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  • [Title] EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors.
  • To gain the insight into the involvement of signaling mediated by the mammalian target of rapamycin (mTOR) in the phenotype and biological profiles of tumors and tumor-like lesions of the bone and soft tissue, we analyzed the expression and phosphorylation (activation) of mTOR and its correlation with the status of upstream and downstream modulator proteins Akt, p70S6-kinase (S6K), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which we refer to collectively as mTOR cassette proteins.
  • Immunohistochemical analysis of 140 cases showed activation of Akt in 55% (61% in malignant and 27% in benign), and mTOR expression in 61% (66% in malignant and 39% in benign).
  • The preponderance of mTOR activation was found in tumors of peripheral nerve sheath (malignant peripheral nerve sheath tumor and schwannoma), skeletal muscle origin (rhabdomyosarcoma), and in those exhibiting epithelial nature (chordoma and synovial sarcoma).
  • Overall, these results suggest that inhibitors of mTOR cassette may be useful as novel components of combined chemotherapy for a defined subset of bone and soft tissue sarcomas.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / analysis. Bone Neoplasms / enzymology. Phosphoproteins / analysis. Protein Kinases / analysis. Proto-Oncogene Proteins c-akt / analysis. Receptor, Epidermal Growth Factor / analysis. Ribosomal Protein S6 Kinases, 70-kDa / analysis. Signal Transduction. Soft Tissue Neoplasms / enzymology

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  • (PMID = 19648884.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / EIF4EBP1 protein, human; 0 / Phosphoproteins; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
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9. Goyal R, Saikia UN, Vashishta RK, Gulati G, Sharma RK: Intraosseous schwannoma of the frontal bone. Orthopedics; 2008 Mar;31(3):281
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  • [Title] Intraosseous schwannoma of the frontal bone.
  • Schwannomas or neurilemomas are relatively frequent benign tumors; however, intraosseous schwannomas are rare.
  • The most common site for intraosseous schwannoma is the mandible.
  • The skull vault is a rare site for intraosseous schwannoma, and only 4 cases have been reported previously in the literature.
  • This article presents a case of intraosseous schwannoma in the frontal bone in an 11-year-old boy.
  • Radiologically, intraosseous schwannomas are lytic, sharply demarcated defects that often expand the involved bone.
  • In our patient, typical radiologic and histologic findings including immunohistochemistry and electron microscopy results led to a diagnosis of intraosseous schwannoma.
  • [MeSH-major] Frontal Bone / pathology. Frontal Bone / radiography. Neurilemmoma / pathology. Neurilemmoma / radiography. Skull Neoplasms / pathology. Skull Neoplasms / radiography

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  • (PMID = 19292228.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Dhouib M, Briki S, Ben Mahfoudh K, Karray F, Boudawara T, Mnif J, Abdelmoula M: [Melanotic schwannoma of the temporozygomatic region]. Rev Stomatol Chir Maxillofac; 2007 Apr;108(2):139-42
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  • [Title] [Melanotic schwannoma of the temporozygomatic region].
  • INTRODUCTION: Melanotic schwannoma is a rare benign tumor, which arises from nerve sheath cells.
  • CASE REPORT: We report a case of melanotic schwannoma arising in the temporozygomatic region for a man of 38-year-old.
  • DISCUSSION: This benign neoplasm occurs pronominally in spinal nerve roots.
  • [MeSH-major] Neurilemmoma / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Temporal Bone / pathology. Zygoma / pathology

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  • (PMID = 17363019.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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11. Kujala S, Kallioinen M, Forsman M, Ryhänen J: Intraosseous schwannoma of the middle phalanx. Scand J Plast Reconstr Surg Hand Surg; 2006;40(5):318-20
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  • [Title] Intraosseous schwannoma of the middle phalanx.
  • Intraosseous schwannoma is an extremely rare, benign neoplasm.
  • We present a case of intraosseous schwannoma of the middle phalanx of the right ring finger.

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  • (PMID = 17065125.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Buric N, Jovanovic G, Pesic Z, Krasic D, Radovanovic Z, Mihailovic D, Tijanic M: Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol; 2009 Mar;38(3):178-81
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  • [Title] Mandible schwannoma (neurilemmoma) presenting as periapical lesion.
  • Schwannoma is a benign nerve tumour that originates from Schwann cells, which cover peripheral nerves.
  • Intraosseous schwannoma of the jaw is rare.
  • Primary schwannoma of the mandible presenting as a periapical radiolucency on a non-vital endodontically treated tooth has rarely been referred to in the English medical literature.
  • A rare case of intraosseous schwannoma is reported in a 23-year-old woman.
  • Histological and immunohistochemical examination showed that the lesion was a primary intraosseous schwannoma of the mandible.
  • Radiographically, mandibular intraosseous schwannoma is difficult to differentiate from bone tumours such as ameloblastoma, myxoma, fibrous dysplasia, neurofibroma, central giant cell lesion or periapical lesion, so it should be included in the list of possible periapical pathoses.
  • [MeSH-major] Mandibular Neoplasms / radiography. Neurilemmoma / radiography. Periapical Diseases / radiography

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  • (PMID = 19225090.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins
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13. Sheikh HY, Chakravarthy RP, Slevin NJ, Sykes AJ, Banerjee SS: Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. J Laryngol Otol; 2008 Jun;122(6):598-602
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  • [Title] Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties.
  • OBJECTIVES: To highlight the difficulty in making a correct diagnosis of benign schwannoma in the paranasal region, to raise awareness of this rare condition, and to suggest the most appropriate treatment.
  • Radiological appearances of local bone invasion and histological features of tumour unencapsulation and hypercellularity could give the mistaken impression of malignant disease and lead to unnecessary over-treatment.
  • [MeSH-major] Ethmoid Sinus / pathology. Neurilemmoma / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17705894.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Meyer A, Sailhan F, Coulomb A, Thevenin-Lemoine C, Mary P, Ducou-Lepointe H, Damsin JP: Proximal tibial epiphyseal intraosseous schwannoma: a rare entity. J Pediatr Orthop; 2008 Oct-Nov;28(7):786-90
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  • [Title] Proximal tibial epiphyseal intraosseous schwannoma: a rare entity.
  • Schwannoma is a benign nerve sheath tumor most commonly located in the soft tissue.
  • The rarity of osseous involvement leads to omission of schwannoma from the initial differential diagnosis in the majority of cases.
  • We present the case of a schwannoma affecting the proximal tibial epiphysis in a growing child.
  • Intraosseous schwannomas should be included in the differential diagnosis of lytic epiphyseal benign-appearing bone lesions in children.
  • Its radiographic characteristics mimic those of benign chondroblastoma.
  • [MeSH-major] Bone Neoplasms / pathology. Neurilemmoma / pathology. Tibia / pathology

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  • [CommentIn] J Pediatr Orthop. 2010 Jun;30(4):411 [20502244.001]
  • (PMID = 18812908.001).
  • [ISSN] 1539-2570
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Moon SE, Cho YJ, Kwon OS: Subungual schwannoma: a rare location. Dermatol Surg; 2005 May;31(5):592-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subungual schwannoma: a rare location.
  • BACKGROUND: Schwannoma is a benign tumor of neural tissue and usually develops in deeper soft tissue.
  • OBJECTIVE: To present a case of subungual schwannoma.
  • CONCLUSION: We describe a case of schwannoma that developed in the subungual area of a thumb.
  • Although schwannoma rarely develops in this area, it should be considered in the differential diagnosis of subungual tumor.
  • [MeSH-major] Bone Neoplasms / diagnosis. Nails, Malformed / etiology. Neurilemmoma / diagnosis

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  • (PMID = 15962750.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Zhang HY, Yang GH, Chen HJ, Wei B, Ke Q, Guo H, Ye L, Bu H, Yang K, Zhang YH: Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl); 2005 Sep 5;118(17):1451-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma.
  • BACKGROUND: Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • The description of the course of the tumors differs somewhat, but it is generally considered as a benign lesion.
  • We investigated the clinicopathologic features, immunophenotypes, and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma (NPMS).
  • The tumor sites included the spinal nerve root (5 patients), cranial nerve (1), greater omentum (1), subcutaneous tissue (3), mesentery (1), bone (1) and mediastinum (1).
  • CONCLUSIONS: Histologically, melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • Immunohistochemically, combined use of laminin and collagen IV is valuable in distinguishing melanotic schwannoma from malignant melanoma.
  • Further studies including cytogenetic or molecular biology are still required to better delineate melanotic schwannoma from malignant melanoma.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16157048.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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17. Soni CR, Kumar G, Sahota P, Miller DC, Litofsky NS: Metastases to Meckel's cave: report of two cases and comparative analysis of malignant tumors with meningioma and schwannoma of Meckel's cave. Clin Neurol Neurosurg; 2010 Dec;112(10):927-32
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  • [Title] Metastases to Meckel's cave: report of two cases and comparative analysis of malignant tumors with meningioma and schwannoma of Meckel's cave.
  • A comparative analysis of clinical features of malignant tumors of Meckel's cave with meningioma and schwannoma of Meckel's cave is discussed.
  • Our findings were then compared with well described case series of meningioma and schwannoma involving Meckel's cave.
  • CONCLUSION: Subtle clinical clues may help differentiate malignant from benign involvement of Meckel's cave.
  • [MeSH-major] Meningioma / secondary. Meningioma / surgery. Neurilemmoma / secondary. Neurilemmoma / surgery. Skull Base Neoplasms / secondary. Skull Base Neoplasms / surgery. Temporal Bone / pathology

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20728984.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Netherlands
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18. Baranović M, Macan D, Begović EA, Luksic I, Brajdić D, Manojlović S: Schwannoma with secondary erosion of mandible: case report with a review of the literature. Dentomaxillofac Radiol; 2006 Nov;35(6):456-60
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  • [Title] Schwannoma with secondary erosion of mandible: case report with a review of the literature.
  • Schwannoma (neurilemmoma) is a common, histologically distinctive, benign, usually encapsulated, peripheral nerve tumour of Schwann cell origin.
  • We report a case of schwannoma arising from soft tissue near the mandible.
  • [MeSH-major] Gingival Neoplasms / complications. Mandibular Diseases / etiology. Mandibular Neoplasms / complications. Neurilemmoma / complications
  • [MeSH-minor] Bone Resorption / etiology. Female. Humans. Middle Aged

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  • (PMID = 17082339.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
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19. Okada K, Ito K, Yamasoba T, Ishii M, Iwasaki S, Kaga K: Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management. Acta Otolaryngol Suppl; 2007 Dec;(559):71-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management.
  • CONCLUSION: Among mass lesions inside the temporal bone, benign tumors and cholesteatomas can be differentiated by contrast enhancement in T1-weighted images (T1WI) and by diffusion-weighted images (DWI).
  • OBJECTIVES: To review the imaging characteristics of mass lesions inside the temporal bone and to investigate pertinent imaging modalities for differential diagnosis, which is crucial for appropriate treatment planning.
  • PATIENTS AND METHODS: This was a retrospective case series study of six patients seen between 2002 and 2005 with mass lesions deep inside the temporal bone.
  • RESULTS: One patient had facial schwannoma, two had glomus jugulare tumor, and three had cholesteatoma.
  • MRI study provided us with better clues: contrast enhancement on T1WI was observed only in benign tumors and only cholesteatomas showed high intensity on DWI.
  • [MeSH-major] Cholesteatoma, Middle Ear. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / surgery. Facial Nerve. Glomus Jugulare Tumor / diagnosis. Granuloma / diagnosis. Granuloma / surgery. Mucocele / diagnosis. Neurilemmoma / diagnosis. Neurilemmoma / surgery. Temporal Bone

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  • (PMID = 18340574.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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20. Wang W, Tavora F, Sharma R, Eisenberger M, Netto GJ: PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma. Urol Oncol; 2009 Sep-Oct;27(5):525-8
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  • [Title] PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma.
  • OBJECTIVES: Radioimmunoscintigraphy using a radiolabeled antibody against prostate-specific membrane antigen (PSMA) is frequently used to detect prostate carcinoma (PCa) recurrence and metastasis to lymph nodes, soft tissues, and bone.
  • PSMA expression has not been described in benign neoplasms.
  • Recently, during evaluation of a prostatic carcinoma patient, we encountered a false positive PSMA radioimmunoscintigraphy scan in a pathologically confirmed Schwannoma (SCH) lesion.
  • CONCLUSION: This is the first report of PSMA expression in a benign neoplasm.
  • [MeSH-major] Antigens, Surface / biosynthesis. Biomarkers, Tumor / analysis. Glutamate Carboxypeptidase II / biosynthesis. Neurilemmoma / diagnosis

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  • (PMID = 18534872.001).
  • [ISSN] 1873-2496
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / Biomarkers, Tumor; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human
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21. Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW: Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism. Am J Dermatopathol; 2009 Dec;31(8):808-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.
  • Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features.
  • We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis.
  • Case 1 involves a 40-year-old woman with a 1.8-cm, deeply pigmented, trigeminal nerve mass and pigmentation of the maxillary sinus mucosa and bone.
  • Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma.
  • Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology

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  • (PMID = 19786855.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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22. Patel RM, Folpe AL: Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. Pathology; 2009;41(6):527-32
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  • [Title] Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours.
  • We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours.
  • METHODS: Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using steam heat-induced epitope retrieval and the Dako Envision system.
  • RESULTS: hTERT expression was seen in nine of 71 (13%) benign and 33 of 72 (46%) malignant tumours (p > or = 0.001).
  • Among benign tumours, only schwannomas and chondromas were positive in >30% of cases.
  • CONCLUSIONS: hTERT expression is significantly more common in sarcomas as compared with benign tumours.
  • Importantly, however, hTERT can be expressed in some benign tumours, notably schwannoma and chondroma, and it is doubtful that hTERT expression alone will allow the discrimination of benign from malignant soft tissue/bone tumours.
  • [MeSH-major] Bone Neoplasms / enzymology. Sarcoma / enzymology. Soft Tissue Neoplasms / enzymology. Telomerase / metabolism

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  • (PMID = 19900100.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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23. Sciarretta V, Pasquini E, Frank G, Modugno GC, Cantaroni C, Mazzatenta D, Farneti G: Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases. Am J Rhinol; 2006 Jan-Feb;20(1):64-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases.
  • BACKGROUND: The endoscopic approach can be used successfully for the treatment of benign tumors such as fibroosseous and vascular lesions, pleomorphic adenoma, glioma, meningioma, and schwannoma.
  • METHODS: Thirty-three patients diagnosed with benign tumors of the nasal cavity and paranasal sinuses and treated using an endoscopic approach were reviewed retrospectively.
  • The mean follow-up was 28 months and only two recurrences (6%) were observed in the juvenile angiofibroma group and in the case of the fibrous dysplasia associated to aneurysmal bone cyst, respectively, 20 and 24 months postoperatively.
  • CONCLUSION: In selected cases, endoscopic surgery can be considered an effective treatment for the resection of benign tumors involving the sinonasal tract.

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  • (PMID = 16539297.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Kim CS, Suh MW: Skull base surgery for removal of temporal bone tumors. Acta Otolaryngol Suppl; 2007 Oct;(558):4-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skull base surgery for removal of temporal bone tumors.
  • OBJECTIVES: The purpose of this study was to review cases that underwent skull base surgery for a variety of tumors that involved the temporal bone.
  • RESULTS: Among the 91 patients, 61 cases had benign disease and 30 had malignancies.
  • A facial nerve schwannoma was the most common benign intratemporal tumor and a squamous cell carcinoma was the most common malignant tumor.
  • With the facial nerve schwannoma, facial nerve paralysis and hearing loss were the most common presenting complaints; otalgia was the most common presenting symptom for temporal bone cancer.
  • Partial temporal bone resection and subtotal temporal bone resections were performed in cases with temporal bone cancer.
  • The disease free 5-year survival of the temporal bone cancers was 42% and for the squamous cell carcinomas, it was 44%.
  • [MeSH-major] Otorhinolaryngologic Surgical Procedures / methods. Skull Base / surgery. Skull Neoplasms / surgery. Temporal Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Cerebrospinal Fluid Otorrhea / etiology. Child. Child, Preschool. Cranial Nerve Neoplasms / surgery. Dizziness / etiology. Earache / etiology. Facial Nerve Diseases / surgery. Facial Paralysis / etiology. Female. Glomus Tumor / blood supply. Glomus Tumor / surgery. Hearing Loss / etiology. Hoarseness / etiology. Humans. Infant. Male. Middle Aged. Muscle Weakness. Neurilemmoma / surgery. Retrospective Studies. Tinnitus / etiology. Vertigo / etiology

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  • (PMID = 17882564.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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25. Lin O, Crapanzano JP: Fine-needle aspiration cytology of pleomorphic hyalinized angiectatic tumor: A case report. Diagn Cytopathol; 2005 Apr;32(4):238-42
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  • The differential diagnosis include solitary fibrous tumor (SFT) and ancient schwannoma, which also shows fibrous-like material and spindle cells that may have intranuclear inclusions.
  • [MeSH-major] Bone Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Knee / pathology. Neurilemmoma / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754361.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. de Silva DJ, Tay E, Rose GE: Schwannomas of the lacrimal gland fossa. Orbit; 2009;28(6):433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Schwannomas are rare benign nerve sheath tumours that account for 1% of orbital tumours and, although sometimes associated with neurofibromatosis, most occur as isolated lesions and arise from branches of the ciliary or trigeminal nerves.
  • METHODS: Two rare cases of Schwannoma arising within the lacrimal gland fossa are presented, these tumours being managed with intact surgical excision.
  • On a presumptive preoperative diagnosis of pleomorphic adenoma, the patient underwent a bone-swinging lateral orbitotomy with intact excision of a moderately-firm, lobulated lesion which proved to be a Schwannoma.
  • CONCLUSIONS: Two very rare cases of Schwannoma arising within the lacrimal gland fossa are presented, the tumours causing complete atrophy of the normal orbital lobe of the lacrimal gland.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neurilemmoma / pathology

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  • (PMID = 19929679.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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27. Zhang QH, Liu HS, Kong F: [Endoscopic endonasal surgery for tumors of petroclival region and infratemporal fossa]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Jul;40(7):488-92
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  • There were 5 chordoma, 1 esthesioneuroblastoma, 1 chondrosarcoma, 1 lymphoma, 1 craniopharyngioma, 1 hemangioblastoma, 4 meningioma, 1 schwannoma, and 2 metastatic carcinoma.
  • The other cases with benign tumors were no recurrence.
  • [MeSH-major] Endoscopy / methods. Petrous Bone / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16200953.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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28. Huang Q, Wu H, Wang Z, Zhang Z, Jia H: [Diagnosis and treatment of lateral skull base tumors in pediatric]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):734-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One had schwannoma of the trigeminal nerve, one had malignant melanoma, one had fibroma in temporal bone, one had chordoma, two had rhabdomyosarcoma, two had esthesioneuroblastoma.
  • The other 7 cases of benign or malignant tumors underwent surgery in different approaches.
  • CONCLUSION: Tumors in lateral skull base in children were rare, of which malignant tumors were more common compared to benign lesions.
  • Combined approach of temporal and infratemporal fossa is suitable for the surgery of those tumors involved temporal bone and middle or posterior cranial fossa as well as infratemporal fossa.

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  • (PMID = 18975775.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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29. Gupta SP, Agarwal A: Intraosseous neurilemmoma of L2 vertebra--a case report. Indian J Pathol Microbiol; 2005 Jul;48(3):367-9
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  • [Title] Intraosseous neurilemmoma of L2 vertebra--a case report.
  • Intraosseous neurilemmoma (schwannoma) is a rare bone tumor with incidence less than 0.2% of all primary bone tumors.
  • It is a benign neoplasm arising from the schwann cells of the nerve sheath.
  • This paper reports an unusual occurrence of intraosseous neurilemmoma in L2 vertebral body.
  • A computed tomograph assisted needle biopsy revealed the tumor to be neurilemmoma.
  • Remaining tumor was curettedfrom bone and the cavity packed with autograft.
  • The aim of this article is to highlight intraosseous neurilemmoma as a possible differential diagnosis in bony tumors.
  • Intraosseous neurilemmoma of lumbar vertebrae is an extremely rare occurrence and till date only four cases are reported in English literature.
  • [MeSH-major] Lumbar Vertebrae / pathology. Neurilemmoma. Spinal Neoplasms

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  • (PMID = 16761755.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 4
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30. Fukaya R, Yoshida K, Ohira T, Kawase T: Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev; 2010 Apr;34(2):159-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trigeminal schwannoma is a mostly benign tumor that can be cured by complete resection.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cranial Fossa, Middle / surgery. Dura Mater / surgery. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Radiosurgery. Retrospective Studies. Skull Base / surgery. Temporal Bone / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20963463.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Isaradisaikul S, Navacharoen N, Hanprasertpong C, Kangsanarak J, Panyathong R: Causes and time-course of vertigo in an ear, nose, and throat clinic. Eur Arch Otorhinolaryngol; 2010 Dec;267(12):1837-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Common causes of vertigo were benign paroxysmal positional vertigo (BPPV) 52.5%, Meniere's disease 14.6%, and sudden idiopathic hearing loss 2.9%.
  • Less common diagnoses were benign paroxysmal vertigo of childhood 0.7%, labyrinthitis 0.7%, and vestibular schwannoma 0.3%.
  • Rare conditions were delayed endolymphatic hydrops, Ramsey Hunt syndrome, otosyphilis, vestibular neuritis, temporal bone fracture, post-concussion syndrome, cerebellar infarction, epilepsy, cervical vertigo, Streptococcus suis meningitis, and psychogenic vertigo.

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  • (PMID = 20567978.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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32. Hussein HA, Goda HA: Paravertebral neurogenic tumors with intraspinal extension: preoperative evaluation and surgical approach. J Egypt Natl Canc Inst; 2009 Mar;21(1):12-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All patients had CT with guided biopsy and MRI to evaluate extent of tumor bone invasion, intraspinal component, to decide surgical approach and the need for spine fixation.
  • Benign schwannoma were diagnosed in 5 cases, malignant schwannoma in 3, neurofibromatosis in one case, neuroblastoma in 3 cases, ganglioneuroblastoma in 2 cases and ganglioneuroma in 2 cases.

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  • (PMID = 20601967.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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33. Martin-Duverneuil N, Auriol M, Behin A, Bertrand JC, Chiras J: Facial malignant peripheral nerve sheath tumors. J Neuroradiol; 2006 Oct;33(4):237-49

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Radiological features display a large spectrum of abnormalities from a well-delineated heterogeneous appearance simulating benign schwannoma to extensive erosive patterns.
  • Their development along the mandibular nerve, the absence of any target or central dot sign, their strong predominant peripheral enhancement must suggest the diagnosis of MPNSTs while irregular bone destruction or the detection of poorly defined margins with muscular infiltration are the most reliable criteria of malignancy.

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  • (PMID = 17041528.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 46
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