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Items 1 to 66 of about 66
1. Lee VN, Nithyananth M, Cherian VM, Amritanand R, Venkatesh K, Sundararaj GD, Raghuram LN: Preoperative embolisation in benign bone tumour excision. J Orthop Surg (Hong Kong); 2008 Apr;16(1):80-3
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  • [Title] Preoperative embolisation in benign bone tumour excision.
  • PURPOSE: To assess the role of preoperative embolisation in benign bone tumour excision.
  • METHODS: 3 men and 3 women aged 19 to 35 (mean 23) years with either a giant cell tumour or an aneurysmal bone cyst in limb girdle sites underwent preoperative embolisation a day prior to wide local excision by the same surgeon.
  • Tumour size, blood loss, wound healing, infection, and tumour recurrence were assessed.
  • No tumour recurred within a minimum 5-year follow-up.
  • CONCLUSION: Preoperative embolisation is useful in the management of vascular and aggressive bone tumours located at limb girdle sites where a tourniquet cannot be used.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Embolization, Therapeutic. Giant Cell Tumor of Bone / surgery. Preoperative Care

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  • (PMID = 18453665.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Moskovszky L, Dezsö K, Athanasou N, Szendröi M, Kopper L, Kliskey K, Picci P, Sápi Z: Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability. Mod Pathol; 2010 Mar;23(3):359-66
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  • [Title] Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
  • Giant cell tumour of bone, a benign but potentially aggressive neoplasm, shows an increasing rate of chromosomal aneusomy that correlates with clinical course.
  • Mechanisms that generate chromosomal instability in giant cell tumour of bone are poorly understood.
  • To gain an insight into the possible mechanism for the generation of chromosomal instability in giant cell tumour of bone, we analysed 100 cases, including 57 primary nonrecurrent, 35 recurrent and 8 malignant giant cell tumour of bone cases. gamma-Tubulin immunohistochemistry was performed on tissue microarrays of 59 formalin-fixed paraffin-embedded cases, whereas pericentrin and gamma-tubulin fluorescent immunocytochemistry was carried out on 41 frozen smears.
  • Centrosome amplification was significantly higher in recurrent and malignant giant cell tumour of bones compared with nonrecurrent tumours (P<0.001).
  • These findings indicate that centrosome alteration and frequency of aneusomy correlate with clinical behaviour; the lack of an association between centrosome amplification and chromosome number alteration suggests that alternative causative mechanisms produce genetic instability in giant cell tumour of bone.
  • [MeSH-major] Bone Neoplasms / genetics. Centrosome / pathology. Chromosomal Instability. Giant Cell Tumor of Bone / genetics

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  • (PMID = 20062006.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Tubulin; 0 / pericentrin
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3. Beaufour A, Cazals-Hatem D, Regimbeau JM, Ponsot P, Degott C, Belghiti J, Sauvanet A: [Osteoclastic giant cell tumour of the pancreas]. Gastroenterol Clin Biol; 2005 Feb;29(2):197-200
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  • [Title] [Osteoclastic giant cell tumour of the pancreas].
  • [Transliterated title] Tumeur à cellules géantes ostéoclastiques du pancréas.
  • Osteoclast giant cell tumours are bone tumours that occur in adults, and that are considered benign by WHO but locally aggressive.
  • Strictly identical tumours are described in the pancreas, without simultaneous bone localization.
  • We report the case of a 62-year woman with an osteoclast giant cell tumour of the distal pancreas, without any epithelial component, which was diagnosed after pancreatic resection and with no signs of recurrence after a 24-month follow-up.
  • These pancreatic tumours are rare, with a very poor prognosis, an unclear histogenesis; they are often confused with pleomorphic or undifferentiated pancreatic carcinomas including a component of osteoclast giant cell.
  • These osteoclast giant cell tumours of the pancreas usually present as large cystic tumours.
  • [MeSH-major] Giant Cell Tumor of Bone. Pancreatic Neoplasms

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  • (PMID = 15795672.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Thomas DM, Skubitz KM: Giant cell tumour of bone. Curr Opin Oncol; 2009 Jul;21(4):338-44
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  • [Title] Giant cell tumour of bone.
  • PURPOSE OF REVIEW: Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / therapy. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / therapy

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  • (PMID = 19444102.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / RANK Ligand; 0 / TNFSF11 protein, human; 4EQZ6YO2HI / Denosumab
  • [Number-of-references] 60
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5. Meyer A, Bastian L, Bruns F: Benign giant cell tumor of the spine: an unusual indication for radiotherapy. Arch Orthop Trauma Surg; 2006 Oct;126(8):517-21

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  • [Title] Benign giant cell tumor of the spine: an unusual indication for radiotherapy.
  • INTRODUCTION: Giant cell tumors are rare primary bone tumors.
  • CASE REPORT: We report about a 64-year-old female patient presenting with history of three osseous and one pulmonal manifestation of a benign giant cell tumor that have manifested metachronously within 23 years.
  • The two periphery bone and the one pulmonal manifestation were treated surgically with success.
  • Nine months later, local recurrence of this benign giant cell tumor developed at the thoracic spine and was treated with radiotherapy with a total dose of 45 Gy.
  • Due to neurological deficits a laminectomy and a stabilization of the destroyed sixth vertebra with bone cement was carried out.
  • Histopathological examination again showed benign giant cell tumor without suspicion of malignancy.
  • CONCLUSION: In the literature the use of radiation therapy remains an appropriate therapy option in benign giant cell tumors with minimal adverse sequelae if primary surgical treatment is not feasible or fails.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16810546.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Ech-Charif S, Aubert S, Buob D, Verhulst P, Blomme V, Migaud H, Leroy X: [Giant cell tumor of soft tissues. Report of two cases]. Ann Pathol; 2006 Feb;26(1):26-9

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  • [Title] [Giant cell tumor of soft tissues. Report of two cases].
  • [Transliterated title] Tumeur à cellules géantes des tissus mous.
  • We report two cases of giant-cell tumour of soft tissue (TCG-TM).
  • The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg.
  • Pathological study revealed a tumour comparable to benign giant cell tumour of bone.
  • The patient is well without recurrence 10 months after the diagnosis.
  • Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells.
  • TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone.
  • The differential diagnosis includes other tumours rich in osteoclast-like cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Female. Giant Cells / pathology. Humans. Leukocytes, Mononuclear / pathology. Male. Middle Aged

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  • (PMID = 16841007.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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7. Malek F, Krueger P, Hatmi ZN, Malayeri AA, Faezipour H, O'Donnell RJ: Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy. Int Orthop; 2006 Dec;30(6):495-8
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  • [Title] Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy.
  • Giant cell tumour (GCT) is a benign, but aggressive, primary tumour of the bone.
  • Many surgical techniques have been employed in the treatment of this tumour.
  • In addition to curettage, various adjuvant procedures and packing materials have been advocated in order to control and reconstruct long bone defects secondary to this neoplasm.
  • We report our experience with 40 long bone GCT patients treated with curettage, burring, bone grafting and no adjuvants between 1997 and 2002.
  • The risk of local recurrence in this study is acceptable (within the range that has been historically reported for curettage and bone grafting).
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Giant Cell Tumor of Bone / surgery

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  • (PMID = 16896875.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3172751
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8. Lim YW, Tan MH: Treatment of benign giant cell tumours of bone in Singapore. Ann Acad Med Singapore; 2005 Apr;34(3):235-7
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  • [Title] Treatment of benign giant cell tumours of bone in Singapore.
  • INTRODUCTION: Giant cell tumour (GCT) is a distinct neoplasm of undifferentiated cells.
  • The exact cell of origin is unknown.
  • The multinucleated giant cells present are formed from the fusion of mononuclear cells.
  • Giant cell tumour is more common in Southeast Asia than in the West.
  • MATERIALS AND METHODS: Sixteen patients with giant cell tumour were treated in the Singapore General Hospital from 1993 to 2001.
  • All the recurrences had a Campanacci grade II or III tumour.
  • CONCLUSION: Currettage, high-speed burring with added phenol/liquid nitrogen treatment and cementation is a useful and safe method in the treatment of giant cell tumours.
  • [MeSH-major] Bone Neoplasms / therapy. Giant Cell Tumor of Bone / therapy

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  • (PMID = 15902343.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 339NCG44TV / Phenol; BBX060AN9V / Hydrogen Peroxide
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9. Marioni G, Marchese-Ragona R, Guarda-Nardini L, Stramare R, Tognazza E, Marino F, Staffieri A: Giant cell tumour (central giant cell lesion) of the maxilla. Acta Otolaryngol; 2006 Jul;126(7):779-81

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  • [Title] Giant cell tumour (central giant cell lesion) of the maxilla.
  • The giant cell tumour (GCT) is a benign, locally invasive lesion that accounts for about 20% of benign bone tumours.
  • Giant cell lesions in the craniofacial skeleton other than the jaws are uncommon; the majority of them occur in the sphenoid, ethmoid and temporal bones.
  • Our successful maxillary reconstruction based on the association between autologous calvarial bone sticks bent with titanium miniplates and a temporalis muscle pedicled flap allowed the involvement of only one donor area for both hard and soft tissues.
  • [MeSH-major] Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / surgery. Maxillary Neoplasms / diagnosis. Maxillary Neoplasms / surgery

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  • (PMID = 16803721.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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10. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: Telomere biology in giant cell tumour of bone. J Pathol; 2008 Apr;214(5):555-63
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  • [Title] Telomere biology in giant cell tumour of bone.
  • Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases.
  • It consists of uniformly distributed osteoclastic giant cells in a background of mononuclear rounded and spindle-shaped cells.
  • GCTB has often been regarded as a polyclonal tumour, but more recently a recurrent specific aberration was reported, which suggests a possible role for disturbed telomere maintenance.
  • Both osteoclastic giant cells and mononuclear cells showed positivity for hTERT and promyelocytic leukaemia body-related antigen.
  • These findings strongly suggest that these aggregates, while activating telomerase, are part of a structural telomere protective-capping mechanism rather than of a telomere-lengthening mechanism.
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumors / genetics. Telomere / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Male. Microscopy, Confocal. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. Phosphoproteins / metabolism. RNA-Binding Proteins / metabolism. Telomerase / metabolism. Transcription Factors / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18278785.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / nucleolin; 143220-95-5 / PML protein, human; EC 2.7.7.49 / Telomerase
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11. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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12. Dhillon MS, Prasad P: Multicentric giant cell tumour of bone. Acta Orthop Belg; 2007 Jun;73(3):289-99
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  • [Title] Multicentric giant cell tumour of bone.
  • Although giant cell tumour (GCT) is seen quite frequently, multicentric giant cell tumour (MCGCT) is a rare entity occurring in less than 1% of patients with GCT.
  • The pathogenesis of MCGCT is debated; various mechanisms have been postulated, including contiguous spread, iatrogenic tumour cell seeding, benign metastasis, malignant transformation and de novo formation.
  • Individual lesions in a patient with MCGCT are radiologically and histologically indistinguishable from the solitary GCT.
  • [MeSH-major] Bone Neoplasms. Giant Cell Tumor of Bone

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  • (PMID = 17715717.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 77
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13. Lazaretti NS, Dallagasperina VW, Villaroel RU, Schlittler LA: [Giant cell tumour of distal femur with pulmonary metastases]. Rev Port Pneumol; 2010 Mar-Apr;16(2):331-7
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  • [Title] [Giant cell tumour of distal femur with pulmonary metastases].
  • [Transliterated title] Tumor de células gigantes de fémur distal com metástases pulmonares.
  • Gian cell is normally a benign primary skeletal lesion located in the epiphysis of the long bones.
  • It is more frequente in the third and fourth decades of life but can exhibit the behaviour of a malignant tumour with distal metatasis.
  • The treatment of primary tumour is extensive surgical resection.
  • We report a case of a 35-year-old patient with lung metatases 21 months after curettage of giant cell tumour in distal femur.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary

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  • (PMID = 20437009.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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14. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Dridi M, Annabi H, Ben Ghozlen R, Abdelkefi M, Trabelsi M: Giant cell tumour of a phalanx in the foot: a case report. Acta Orthop Belg; 2008 Apr;74(2):273-5
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  • [Title] Giant cell tumour of a phalanx in the foot: a case report.
  • Giant cell tumours are uncommon benign osseous neoplasias with an obscure origin.
  • The authors report a case of giant cell tumour involving a phalangeal bone in the foot and review the presentation, distinctive features and treatment of this tumour when occurring in this location.
  • A 28-year-old female patient was seen with an aggressive giant cell tumour of the first phalangeal bone of the third ray of her left foot.
  • En bloc resection of the third ray was performed without bone grafting.
  • When giant cell tumour occurs in such a location, it appears to represent a distinct, more aggressive form of tumour.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Toe Phalanges

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  • (PMID = 18564489.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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16. Zahid M, Asif N, Sabir AB, Siddiqui YS, Julfiqar M: Metachronous multicentric giant cell tumour of the upper extremity in a skeletally immature girl : A rare presentation. Acta Orthop Belg; 2010 Oct;76(5):694-8
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  • [Title] Metachronous multicentric giant cell tumour of the upper extremity in a skeletally immature girl : A rare presentation.
  • Giant Cell tumour (GCT) or Osteoclastoma is a benign locally aggressive tumour with a tendency for local recurrence.
  • GCT constitutes 5% of all primary bone tumours.
  • Metachronous multicentric giant cell tumour of bone is a rare entity.
  • Multicentric GCT, in contrast to unifocal GCT, has a tendency to involve the small bones of hands and feet, involving the metaphysis/diaphysis of long bones and tends to occur in a slightly younger population.
  • We report a young girl presenting with metachronous multicentric recurrent benign GCT, with the lesions involving the ipsilateral right hand and distal humerus.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Hand Bones. Humerus. Neoplasms, Second Primary / pathology

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  • (PMID = 21138229.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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17. Saw S, Thomas N, Gleeson MJ, Bódi I, Connor S, Hortobágyi T: Giant cell tumour and central giant cell reparative granuloma of the skull: do these represent ends of a spectrum? A case report and literature review. Pathol Oncol Res; 2009 Jun;15(2):291-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour and central giant cell reparative granuloma of the skull: do these represent ends of a spectrum? A case report and literature review.
  • Giant cell tumour (GCT) of bone is an uncommon primary bone neoplasm typically occurring at the epiphyses of long bones in young adults.
  • They demonstrate benign histological features, but are locally aggressive and surgical excision is the treatment of choice.
  • It is widely believed that giant cell tumours should be distinguished from other giant cell lesions, importantly central giant cell reparative granulomata (CGCG) which are thought to have a lower recurrence rate and for which no cases of malignant transformation or metastases have been reported.
  • Investigators have noted that giant cell lesions in the skull bones may be unique and that GCT and CGCG may be part of a spectrum of a single disease process.
  • We present a case of a giant cell tumour of the temporal bone which illustrates and re-emphasises this concept and review the literature on these lesions.
  • [MeSH-major] Giant Cell Tumors / pathology. Granuloma, Giant Cell / pathology. Skull Neoplasms / pathology

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  • (PMID = 19011995.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Nahal A, Ajlan A, Alcindor T, Turcotte R: Dedifferentiated giant cell tumour of bone in the form of low-grade fibroblastic osteogenic sarcoma: case report of a unique presentation with follow-up. Curr Oncol; 2010 Aug;17(4):71-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dedifferentiated giant cell tumour of bone in the form of low-grade fibroblastic osteogenic sarcoma: case report of a unique presentation with follow-up.
  • Giant cell tumour (GCT) of bone is a locally aggressive benign tumour.
  • It can, however, undergo dedifferentiation, either de novo or secondarily after local recurrence or radiation.
  • Whether spontaneously occurring or induced by previous irradiation, this malignant transformation is typically defined as a high-grade anaplastic sarcoma devoid of giant cells.
  • Here, we describe the first case of dedifferentiated GCT in the appearance of low-grade fibroblastic osteogenic sarcoma with distant bone metastases.
  • We confirm the aggressive behaviour of this tumour despite the deceptively bland appearance of the malignant component.

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  • [Cites] Histopathology. 2007 Dec;51(6):864-6 [18042075.001]
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  • (PMID = 20697518.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2913833
  • [Keywords] NOTNLM ; Giant cell tumour / dedifferentiation / malignancy / osteogenic sarcoma
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19. Wan JM, Magarelli N, Peh WC, Guglielmi G, Shek TW: Imaging of giant cell tumour of the tendon sheath. Radiol Med; 2010 Feb;115(1):141-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of giant cell tumour of the tendon sheath.
  • Giant cell tumours of the tendon sheath (GCTTS) and pigmented villonodular synovitis (PVNS) are part of a spectrum of benign proliferative lesions of synovial origin that may affect the joints, bursae and tendon sheaths.
  • GCTTS usually presents as a soft tissue mass with pressure erosion of the underlying bone.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Neoplasms, Connective Tissue / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Tendons / pathology
  • [MeSH-minor] Diagnosis, Differential. Echo-Planar Imaging. Humans. Magnetic Resonance Imaging. Predictive Value of Tests. Sensitivity and Specificity. Ultrasonography, Doppler

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  • (PMID = 20077044.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 49
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20. Baker JF, Perera A, Kiely PD, Lui DF, Stephens MM: Giant cell tumour in the foot of a skeletally immature girl: a case report. J Orthop Surg (Hong Kong); 2009 Aug;17(2):248-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour in the foot of a skeletally immature girl: a case report.
  • We present a case of delayed diagnosis of a benign giant cell tumour (GCT) of the third metatarsal in a skeletally immature girl.
  • The patient underwent en bloc excision of the tumour.
  • The tumour had replaced the third metatarsal and had infiltrated the surrounding soft tissue and the second and fourth metatarsal bases.
  • A high index of suspicion is needed when evaluating any tumours of the foot, because the compact structure of the foot may delay diagnosis.
  • GCT in this location and age-group are rare and should be considered in the differential diagnosis of a destructive bony lesion in skeletally immature patients.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / surgery. Metatarsal Bones / pathology
  • [MeSH-minor] Biopsy. Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 19721166.001).
  • [ISSN] 2309-4990
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Lanza A, Laino L, Rossiello L, Perillo L, Ermo AD, Cirillo N: Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction. Open Dent J; 2008;2:73-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction.
  • Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph.
  • Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive.
  • Therefore a critical differential diagnosis has to be reached to choose the best management.
  • Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion.
  • A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.

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  • (PMID = 19088886.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2581533
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22. Donthineni R, Boriani L, Ofluoglu O, Bandiera S: Metastatic behaviour of giant cell tumour of the spine. Int Orthop; 2009 Apr;33(2):497-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic behaviour of giant cell tumour of the spine.
  • Lung metastases from giant cell tumours (GCT) of the spine have not been specifically addressed in the literature.
  • When there is a recurrence of GCT, with or without metastases, the local and possibly the metastases should be biopsied to confirm the original diagnosis.
  • Progression of benign GCT into an aggressive sarcoma has been documented, and the method of management should be altered.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18461324.001).
  • [ISSN] 1432-5195
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899057
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23. Dominkus M, Ruggieri P, Bertoni F, Briccoli A, Picci P, Rocca M, Mercuri M: Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institution. Int Orthop; 2006 Dec;30(6):499-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institution.
  • From 1975 to 1997, 649 cases of benign giant cell tumours of the bone were treated at the Istituto Rizzoli.
  • The time interval between the diagnosis and the appearance of the lung metastases ranged from 3 months to 11.9 years.
  • Histologically, the metastases were identical to the primary bone lesions.
  • Local recurrence of the bone lesion occurred in seven patients before or simultaneously to the metastases.
  • In contrast to previous reports, we could not detect a predominance of the distal radius, but all of the patients had a stage III tumour according to the Enneking criteria of benign lesions.
  • We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16909252.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3172731
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24. Eyesan SU, Ugwoegbulem OA, Obalum DC: Bone cement in the management of cystic tumour defects of bone at National Orthopaedic Hospital, Igbobi, Lagos. Niger J Clin Pract; 2009 Dec;12(4):367-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone cement in the management of cystic tumour defects of bone at National Orthopaedic Hospital, Igbobi, Lagos.
  • BACKGROUND: Cystic bony defects are characteristics of bone tumours especially benign ones e.g.
  • Giant cell tumours of bone [GCT] and some metastatic tumours to bone.
  • The objective of this study is to evaluate the outcome of filling these defects with bone cement augmented with plate and screw for stability.
  • METHOD: A seven year prospective study was carried out in patients presenting with large cystic bony defects secondary to bone tumours at the oncology unit of the National Orthopaedic Hospital, Igbobi, Lagos.
  • Data such as age, sex, anatomic location of lesions, histological type of tumours, x-ray findings, operation performed with the number of packets of bone cement used to fill the resultant bony defects were retrieved from prepared proforma.
  • Giant cell tumour was the most common histological diagnosis 78.6%.
  • Bone cement was effective in meeting the local requirements of limb salvage, early functional recovery and as a temporising measure until the patients can avail themselves of better options.
  • CONCLUSION: Bone cement augmented with appropriate implants has proven valuable as a stop gap in filling large cystic bony defects resulting from tumours.
  • [MeSH-major] Bone Cements. Bone Cysts / surgery. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Humerus / surgery. Leg Bones / surgery

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  • (PMID = 20329673.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
  • [Chemical-registry-number] 0 / Bone Cements
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25. Bianchi G, Donati D, Staals EL, Mercuri M: Osteoarticular allograft reconstruction of the distal radius after bone tumour resection. J Hand Surg Br; 2005 Aug;30(4):369-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoarticular allograft reconstruction of the distal radius after bone tumour resection.
  • Resection of the distal end of the radius is indicated in the treatment of locally aggressive primary benign and malignant bone tumours.
  • The aim of this study was to evaluate the technique of osteoarticular allograft reconstruction of this bone defect.
  • Three patients had a malignant tumour and nine had a giant cell tumour.
  • Non-union of the osteotomy line was diagnosed 6 months after surgery in one case and needed bone grafting.
  • Subchondral bone alterations and joint narrowing were present in all cases but were painful in only one patient.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Radius / surgery

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  • (PMID = 15951074.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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26. Huda N, Bhardwaj S, Abbas M, Asif N: Giant cell reaction of a metatarsal bone: a case report. Acta Orthop Belg; 2007 Apr;73(2):279-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell reaction of a metatarsal bone: a case report.
  • A rare, non-neoplastic lesion involving the 1st metatarsal bone in a 5-year-old female is described.
  • Fine needle aspiration cytology showed it to be a benign giant cell lesion.
  • The tumour was excised en bloc and the metatarsal replaced by a free fibular graft of adequate length.
  • Histopathological examination confirmed the diagnosis as giant cell reaction of bone.
  • The lesion is said to arise as a local tissue response to bleeding as evidenced by the clustering of giant cells in areas of haemorrhage.
  • The entity should be differentiated from aneurismal bone cyst, brown tumours of hyperparathyroidism giant cell tumour, chondroblastoma, non-ossifying fibroma etc.
  • Treatment usually consists of curettage or excision of the involved bone with or without bone grafting.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cells / pathology. Metatarsal Bones / pathology

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  • (PMID = 17515247.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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27. Capote-Moreno A, Acero J, García-Recuero I, Ruiz J, Serrano R, de Paz V: Giant aneurysmal bone cyst of the mandible with unusual presentation. Med Oral Patol Oral Cir Bucal; 2009 Mar;14(3):E137-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant aneurysmal bone cyst of the mandible with unusual presentation.
  • Aneurysmal bone cysts are rare benign lesions of bone tissue, infrequent in craneofacial skeleton with regard to other structures like long bones or the spine.
  • We present a case of a 29-year-old Caucasian male with a big swelling in the left mandible associated to pain and rapid growth.
  • An incisional biopsy was performed showing a fibrous tissue with blood-filled spaces lesion suggestive of an aneurysmal bone cyst.
  • After selective embolization of the tumour, surgical resection was done with curettage and immediate reconstruction of the defect with an anterior iliac crest graft.
  • Aneurysmal bone cysts are non-neoplastic but locally aggressive tumours with occasional rapid growth that may be differentiated from other multilocular process like ameloblastoma, ossifying fibroma, epithelial cyst, giant cell granuloma and sarcomas.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Mandibular Diseases / diagnosis

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  • (PMID = 19242394.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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28. Singh J, James SL, Kroon HM, Woertler K, Anderson SE, Jundt G, Davies AM: Tumour and tumour-like lesions of the patella--a multicentre experience. Eur Radiol; 2009 Mar;19(3):701-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumour and tumour-like lesions of the patella--a multicentre experience.
  • Fifty-nine cases of lesions presenting in the patella were identified after review of the databases of four European bone tumour registries.
  • Of the 59 cases, 46% were non neoplastic, 39% were benign and 15% were malignant.
  • The commonest benign neoplasm was giant cell tumour (GCT) (11 cases).
  • Younger patients were more likely to have a benign neoplasm.
  • Lesions in patients less than 40 years of age included giant cell tumour, chondroblastoma, aneurysmal bone cyst (ABC), osteomyelitis, osteoid osteoma and solitary bone cyst.
  • Expansion of the patella with thinning of cortex was seen more commonly in GCT and brown tumour in hyperparathyroidism.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumors / pathology. Patella / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Diagnosis, Differential. Female. Humans. Male. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Radiology / methods

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  • [ErratumIn] Eur Radiol. 2010 Mar;20(3):763. Jundt, G [added]
  • (PMID = 18815789.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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29. Schindler OS, Cannon SR, Briggs TW, Blunn GW: Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours. J Orthop Surg (Hong Kong); 2008 Apr;16(1):66-74
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  • [Title] Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.
  • PURPOSE: To report the use of a composite ceramic bone graft substitute containing calcium sulphate and hydroxyapatite (HA) in the treatment of large expansive osteolytic benign bone tumours.
  • METHODS: 4 women and 9 men aged 8 to 49 (mean, 22) years with aneurysmal bone cysts (n=6) or giant cell tumours (n=7) in the epi- or meta-physeal areas of the lower limbs underwent curettage, phenolisation, and filling with bone graft substitute containing calcium sulphate and HA.
  • The mean tumour size was 38.5 (range, 18-65) ml.
  • Range of movement, Musculoskeletal Tumor Society Rating Score (MTSRS), and haematological and blood biochemical parameters were measured.
  • RESULTS: Two patients had recurrence at 7 and 9 months, both progressed to grade-III giant cell tumours.
  • CONCLUSION: Composite bioceramic osteoconductive grafts, which combine porous HA with calcium sulphate, provide a framework for human osteogenesis and avoid donor-site morbidity (autologous bone graft harvesting).
  • Tumour recurrence remains a major concern especially in young patients, as revision invariably requires removal of additional bone, potentially compromising joint integrity.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Bone Substitutes / therapeutic use. Ceramics / therapeutic use. Durapatite / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Female. Femoral Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Tibia / surgery

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  • (PMID = 18453663.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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30. Tsuchiya H, Morsy AF, Matsubara H, Watanabe K, Abdel-Wanis ME, Tomita K: Treatment of benign bone tumours using external fixation. J Bone Joint Surg Br; 2007 Aug;89(8):1077-83
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  • [Title] Treatment of benign bone tumours using external fixation.
  • We present a retrospective study of patients suffering from a variety of benign tumours in whom external fixators were used to treat deformity and limb-length discrepancy, and for the reconstruction of bone defects.
  • The diagnosis was Ollier's disease in 12 limbs, fibrous dysplasia in 11, osteochondroma in eight, giant cell tumour in five, osteofibrous dysplasia in five and non-ossifying fibroma in two.
  • [MeSH-major] Bone Neoplasms / surgery. External Fixators. Fracture Fixation / methods. Neoplasms, Connective Tissue / surgery. Osteochondrodysplasias / surgery. Osteochondroma / surgery

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  • (PMID = 17785749.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Składzieriń J, Olés K, Zagólski O, Moskała M, Sztuka M, Strek P, Wierzchowski W, Tomik J: A giant cranial aneurysmal bone cyst associated with fibrous dysplasia. B-ENT; 2008;4(1):29-33
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  • [Title] A giant cranial aneurysmal bone cyst associated with fibrous dysplasia.
  • An aneurysmal bone cyst (ABC) is a rare, benign fibro-osseous lesion, considered a vascular phenomenon secondary to fibrous dysplasia or a giant-cell tumour, and occurs mainly in long bones and vertebrae.
  • The patient underwent a craniofacial resection of the tumour performed with an external approach and an immediate reconstruction of the dural defect.
  • A large facial aneurysmal bone cyst can damage the facial skeleton and skull base, and requires excision by a combined external approach.
  • [MeSH-major] Bone Cysts, Aneurysmal / etiology. Fibrous Dysplasia of Bone / complications

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  • (PMID = 18500019.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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32. Jeys LM, Suneja R, Chami G, Grimer RJ, Carter SR, Tillman RM: Impending fractures in giant cell tumours of the distal femur: incidence and outcome. Int Orthop; 2006 Apr;30(2):135-8
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  • [Title] Impending fractures in giant cell tumours of the distal femur: incidence and outcome.
  • Giant cell tumours are rare bone tumours that are characteristically benign but locally aggressive, most frequently occurring in the distal femur with pathological fractures being common.
  • This paper investigates relationships between tumour size and cortical breach on initial X-rays and subsequent treatment.
  • The X-rays of 54 patients with distal femoral giant cell tumours were reviewed.
  • The volumes of the tumour, distal femur and a ratio between the two parameters were estimated.
  • The presence of a cortical breach, discrete fracture and Campanacci grade was recorded.
  • There was a significant difference in the ratio of tumour volume to distal femoral volume between the discrete fracture group and the cortical breach group.
  • [MeSH-major] Femoral Fractures / epidemiology. Femoral Fractures / physiopathology. Femoral Neoplasms / physiopathology. Giant Cell Tumor of Bone / physiopathology

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  • [Cites] Clin Orthop Relat Res. 2002 Apr;(397):248-58 [11953616.001]
  • [Cites] J Bone Joint Surg Br. 2004 Jan;86(1):5-12 [14765857.001]
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  • (PMID = 16474936.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2532068
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33. James SL, Davies AM: Giant-cell tumours of bone of the hand and wrist: a review of imaging findings and differential diagnoses. Eur Radiol; 2005 Sep;15(9):1855-66
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  • [Title] Giant-cell tumours of bone of the hand and wrist: a review of imaging findings and differential diagnoses.
  • Giant-cell tumour of bone (GCTOB) is a benign, locally aggressive, primary bone tumour.
  • GCTOB involving the bones of the hand most commonly occurs in a central location, which differs from the usual eccentric location seen in GCTOB at other sites.
  • The role of bone scintigraphy, computed tomography and magnetic resonance imaging is discussed.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carpal Bones / pathology. Diagnostic Imaging. Giant Cell Tumor of Bone / diagnosis. Hand Bones / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 15868123.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Number-of-references] 89
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34. Suárez-Roa Mde L, Reveiz L, Ruíz-Godoy Rivera LM, Asbun-Bojalil J, Dávila-Serapio JE, Menjívar-Rubio AH, Meneses-García A: Interventions for central giant cell granuloma (CGCG) of the jaws. Cochrane Database Syst Rev; 2009;(4):CD007404
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  • [Title] Interventions for central giant cell granuloma (CGCG) of the jaws.
  • BACKGROUND: Central giant cell granuloma (CGCG) of the jaws is a rare benign tumour with an unknown aetiology accounting for up to 7% of tumours in the mandible (lower jaw) and the maxilla (upper jaw).
  • OBJECTIVES: This systematic review focused on assessing the effects of primary non-surgical versus primary surgical interventions or any other treatment or placebo for treating central giant cell granuloma of the jaws.
  • MAIN RESULTS: We did not find any study evaluating the effects of primary surgical versus primary non-surgical interventions for central giant cell granuloma of the jaws.
  • However, we included and analysed one RCT with unclear risk of bias, evaluating the effects of calcitonin versus placebo for central giant cell granuloma of the jaws.
  • AUTHORS' CONCLUSIONS: We did not find RCTs evaluating the effects of primary surgical versus primary non-surgical interventions for central giant cell granuloma of the jaws.
  • Although a number of non-surgical therapies have been proposed for treating central giant cell granuloma of the jaws, our review did not identify evidence from RCTs to support their use.
  • [MeSH-major] Granuloma, Giant Cell / therapy. Mandibular Diseases / therapy. Maxillary Diseases / therapy
  • [MeSH-minor] Bone Density Conservation Agents / therapeutic use. Calcitonin / therapeutic use. Humans

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  • (PMID = 19821413.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 9007-12-9 / Calcitonin
  • [Number-of-references] 32
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35. Hopyan S, Ngan SY, Choong PF: Natural history of tumour-related sacral obliteration with nerve-root preservation. Clin Oncol (R Coll Radiol); 2005 May;17(3):195-8
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  • [Title] Natural history of tumour-related sacral obliteration with nerve-root preservation.
  • Benign aggressive bone tumours can present a dilemma when the definitive treatment options necessitate enormous and permanent functional deficits.
  • Here, we present a case of a massive sacral giant-cell tumour causing dramatic skeletal obliteration, which was successfully treated with radical radiotherapy rather than ablative surgery.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Giant Cell Tumor of Bone / radiotherapy. Sacrum

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  • (PMID = 15901005.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Hori T, Kanamori M, Ohmori K, Nobukiyo M, Kimura T: Giant cell reparative granuloma of the proximal tibia: a case report. J Orthop Surg (Hong Kong); 2008 Dec;16(3):364-7
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  • [Title] Giant cell reparative granuloma of the proximal tibia: a case report.
  • Giant cell reparative granulomas (GCRGs) are non-neoplastic inflammatory lesions, usually of the jaw or gingiva or small bones of the hands and feet.
  • We report one such case in the right proximal tibia of a 45-year-old man.
  • After open biopsy, a preliminary diagnosis of a benign giant cell tumour was made.
  • One month after admission, the lesion was curetted and filled with cancellous bone and hydroxyapatite.
  • Based on the histology of the curetted lesion, the diagnosis was changed to a GCRG.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Granuloma, Giant Cell / diagnosis. Granuloma, Giant Cell / surgery. Tibia

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  • (PMID = 19126908.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Swanger R, Maldjian C, Murali R, Tenner M: Three cases of benign giant cell tumor with unusual imaging features. Clin Imaging; 2008 Sep-Oct;32(5):407-10
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  • [Title] Three cases of benign giant cell tumor with unusual imaging features.
  • OBJECTIVE: Imaging findings for giant cell tumors (GCT) of the spine displaying aggressive characteristics have not been widely reported.
  • CONCLUSION: Acute fracture, subluxation, and extension through the disc space have not been previously described and, while atypical for benign lesions, may in fact be typical for GCT of the spine.
  • [MeSH-major] Fractures, Spontaneous / diagnosis. Giant Cell Tumor of Bone / diagnosis. Spinal Cord Compression / diagnosis. Spinal Fractures / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Low Back Pain / diagnosis. Low Back Pain / etiology. Magnetic Resonance Imaging / methods. Retrospective Studies. Risk Assessment. Sampling Studies. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 18760733.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Amendolara M, Barbarino C, Bucca D, Guarnieri F, Novello GB, Romano FM, Stevanato G, Ranzato R: [Giant and bilateral adrenal myelolipoma. Case report]. G Chir; 2008 Mar;29(3):85-8
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  • [Title] [Giant and bilateral adrenal myelolipoma. Case report].
  • The adrenal myelolipoma is a relatively rare benign tumour of adipose cell and bone marrow elements, non functioning and asymptomatic.
  • Giant and bilateral adrenal myelolipoma is quite rare.
  • The Authors report a case of bilateral adrenal myelolipoma, a giant one (> 15 cm) on the left side and a small one (> 4 cm) on the right with constant pain in a 57-year-old man, shown by computerized tomography.
  • Histology confirmed diagnosis of myelolipoma for both masses.
  • The authors agree with the need to remove the giant adrenal myelolipoma, because the lesion > 10 cm have a high risk of cancer and hemorrhagic complication, while for small myelolipoma (< 6 cm) 6-12 months follow-up is the appropriate choice.

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  • (PMID = 18366886.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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39. George B, Abudu A, Grimer RJ, Carter SR, Tillman RM: The treatment of benign lesions of the proximal femur with non-vascularised autologous fibular strut grafts. J Bone Joint Surg Br; 2008 May;90(5):648-51
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  • [Title] The treatment of benign lesions of the proximal femur with non-vascularised autologous fibular strut grafts.
  • We report our experience of treating 17 patients with benign lesions of the proximal femur with non-vascularised, autologous fibular strut grafts, without osteosynthesis.
  • Histological diagnoses included simple bone cyst, fibrous dysplasia, aneurysmal bone cysts and giant cell tumour.
  • We conclude that non-vascularised fibular strut grafts are a safe and satisfactory method of treating benign lesions of the proximal femur.
  • [MeSH-major] Bone Diseases / surgery. Bone Transplantation / methods. Femur / surgery. Fibula / transplantation
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18450634.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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40. Asavamongkolkul A, Waikakul S, Phimolsarnti R, Kiatisevi P: Functional outcome following excision of a tumour and reconstruction of the distal radius. Int Orthop; 2009 Feb;33(1):203-9
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  • [Title] Functional outcome following excision of a tumour and reconstruction of the distal radius.
  • We retrospectively studied the functional and oncological results of 15 patients after reconstruction of the distal radius with osteoarticular allograft or non-vascularised fibular graft following wide excision of an aggressive benign or malignant tumour.
  • There was no tumour recurrence after follow up over 41.5-95.5 (average 60.5) months.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Giant Cell Tumor of Bone / surgery. Histiocytoma, Malignant Fibrous / surgery. Osteosarcoma / surgery. Radius / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts / surgery. Bone Plates. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 17724593.001).
  • [ISSN] 1432-5195
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899238
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41. Pavlovic S, Valyi-Nagy T, Profirovic J, David O: Fine-needle aspiration of brown tumor of bone: cytologic features with radiologic and histologic correlation. Diagn Cytopathol; 2009 Feb;37(2):136-9
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  • [Title] Fine-needle aspiration of brown tumor of bone: cytologic features with radiologic and histologic correlation.
  • We report the case of a 40-year-old man with tertiary hyperparathyroidism due to end stage renal disease who initially presented with acute-onset paraplegia, elevated serum parathyroid hormone, and multiple bone abnormalities, including a large extradural intraspinal mass seen by magnetic resonance imaging.
  • In contrast with imaging features, fine-needle aspiration cytology showed numerous benign-appearing multinucleated osteoclast-type giant cells that are the characteristics of either brown tumor or benign giant cell tumor of bone.
  • A core-needle biopsy confirmed the diagnostic features of brown tumor of hyperparathyroidism.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Hyperparathyroidism / complications. Hyperparathyroidism / diagnosis. Hyperparathyroidism / pathology. Male. Osteoclasts / pathology

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  • (PMID = 19021196.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Moriceau G, Ory B, Gobin B, Verrecchia F, Gouin F, Blanchard F, Redini F, Heymann D: Therapeutic approach of primary bone tumours by bisphosphonates. Curr Pharm Des; 2010;16(27):2981-7
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  • [Title] Therapeutic approach of primary bone tumours by bisphosphonates.
  • Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant) including mainly osteosarcoma and other sarcomas.ii)and giant cell tumour and bone metastases originate from others cancer (Breast, prostate, kidney cancer, etc).
  • However, the first step of bone tumour development is associated with an induction of bone resorption and the establishment of a vicious cycle between the osteoclasts and the tumour growth.
  • Indeed, bone resorption contributes to the pathogenesis of bone tumour by the release of cytokines (IL6, TNFα) which govern the bone tumour's development and which are trapped into the bone matrix.
  • Bisphosphonates (BPs) are chemical compounds of P-C-P structure with a high affinity for bone hydroxyapatite crystals.
  • Thus, they have been used as a carrier for radio nucleotides to develop novel approaches of bone imaging.
  • BPs exert also indirect anti-tumour activities in vivo.
  • Indeed, BPs directly interfere with the bone microenvironment and target osteoclasts, endothelial cells and immune cells (tumour-associated macrophages, γ9δ2 T cells).
  • BPs induce tumour cell death in vitro and same activity is suspected in vivo.
  • The present review summarizes the mechanisms of actions of BPs as well as their clinical interests in bone primary tumours.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Bone Neoplasms / drug therapy. Diphosphonates / pharmacology. Diphosphonates / therapeutic use. Drug Design
  • [MeSH-minor] Animals. Bone Density Conservation Agents / pharmacology. Bone Density Conservation Agents / therapeutic use. Chondrosarcoma / drug therapy. Giant Cell Tumor of Bone / drug therapy. Humans. Osteosarcoma / drug therapy

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  • (PMID = 20722622.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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43. Yoshioka K, Kawahara N, Murakami H, Demura S, Kawaguchi M, Oda M, Matsumoto I, Tomita K: Cervicothoracic giant cell tumor expanding into the superior mediastinum: total excision by combined anterior-posterior approach. Orthopedics; 2009 Jul;32(7):531
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  • [Title] Cervicothoracic giant cell tumor expanding into the superior mediastinum: total excision by combined anterior-posterior approach.
  • This article describes a case of cervicothoracic giant cell tumor expanding into the superior mediastinum treated by total spondylectomy.
  • The spinal cord was severely compressed by the tumor mass.
  • The tumor had spread from T2 to the mediastinum, so that the tumor was in contact with many vital structures.
  • To resect the tumor completely, total spondylectomy from T1 to T3 was performed through a combined anterior-posterior approach.
  • The tumor was dissected from the vital structures using an anterior low cervical approach and splitting one-third of the sternum.
  • En bloc vertebral resection from Th1 to Th3, including the tumor pseudocapsule, was possible through a posterior approach.
  • The tumor around the nerve roots or dura was resected piece by piece since it was possible to separate the capsulated tumor from the dura.
  • Splitting one-third of the sternum allowed separation of the tumor from the anterior vital structures, under direct vision.
  • This allowed en bloc vertebral resection of the tumor that had spread to the mediastinum from T2 and in the craniocaudal direction from T1 to T3.
  • Although giant cell tumor is benign, it can be locally aggressive.
  • Complete excision of a giant cell tumor is the best treatment option even for the cervicothoracic spine, to protect the vital structures or neural function.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cell Tumors / surgery. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Osteotomy / methods. Reconstructive Surgical Procedures / methods

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  • (PMID = 19634835.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Abdulkareem FB, Eyesan SU, Akinde OR, Ezembakwe ME, Nnodu OE: Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med; 2007 Oct-Dec;26(4):306-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria.
  • BACKGROUND: Although primary bone tumours are relatively uncommon, they constitute the most important tumours in patients under 20 years.
  • OBJECTIVE: To update the literature on the relative frequency and clinico-pathologic characteristics of bone tumours in this environment.
  • MATERIALS AND METHODS: The clinical and histopathological records of patients presenting with diagnosis of bone tumours between 1999 and 2004 and managed at the National Orthopaedic Hospital, Igbobi, (NOHI) Lagos, Nigeria were review and where necessary, new ones were prepared from the paraffin blocks and stained with routine haematoxylin and eosin stain.
  • RESULTS: Seventy-seven cases were recorded; 61 (79.2%) benign and 16 (15.6%) malignant.
  • The commonest benign bone tumours were osteochondroma and giant cell tumour accounting for 52 (67%) of all cases with > 60% in males.
  • The most common primary malignant bone tumour was osteosarcoma, all in males.
  • Four (5.2%) cases of metastatic bone tumours located commonly in the proximal femur and humerus were also recorded.
  • CONCLUSION: Osteochondroma and giant cell tumours are the commonest benign tumours while osteosarcoma is the most common primary bone tumour all occurring in the first two decades of life.
  • [MeSH-major] Bone Neoplasms / pathology

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  • (PMID = 18705432.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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45. Santiago FR, Del Mar Castellano García M, Montes JL, García MR, Fernández JM: Treatment of bone tumours by radiofrequency thermal ablation. Curr Rev Musculoskelet Med; 2009 Mar;2(1):43-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of bone tumours by radiofrequency thermal ablation.
  • Other benign conditions (chondroblastoma, osteoblastoma, giant cell tumour, etc.) can also be treated by this technique, which is less invasive than traditional surgical procedures.
  • In other cases, it is combined with conventional therapies or other percutaneous treatments, e.g., cementoplasty, offering faster pain relief and bone strengthening.

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  • (PMID = 19468917.001).
  • [ISSN] 1935-973X
  • [Journal-full-title] Current reviews in musculoskeletal medicine
  • [ISO-abbreviation] Curr Rev Musculoskelet Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2684952
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46. Yang Q, Li J, Yang Z, Li X, Li Z: Limb sparing surgery for bone tumours of the shoulder girdle: the oncological and functional results. Int Orthop; 2010 Aug;34(6):869-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Limb sparing surgery for bone tumours of the shoulder girdle: the oncological and functional results.
  • It is a great challenge to spare the upper limb with a malignant or invasive benign bone tumour of the shoulder girdle.
  • We retrospectively analysed 35 patients with bone tumours of the shoulder girdle treated with various limb salvage procedures.
  • The tumours included 25 primary malignancies, three metastases and seven giant cell tumours which involved the proximal humerus in 21 patients, scapula in 12 and clavicle in two.
  • The reconstruction procedures included eight prosthetic replacements, four devitalised tumorous bone grafts, three osteoarticular allografts, two autogenous fibular grafts, one intramedullary cemented nail, three Tikhoff-Linberg procedures, two replantation of shortened arms, and four humeral head suspensions.
  • Six partial scapulectomies and two lateral clavicectomies needed no bone reconstruction.
  • The average Musculoskeletal Tumour Society (MSTS) functional score was 77% (range 40-100%) in all patients.
  • [MeSH-major] Bone Neoplasms / surgery. Limb Salvage / methods. Recovery of Function. Shoulder / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement / methods. Bone Transplantation. Child. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19701633.001).
  • [ISSN] 1432-5195
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2989017
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47. Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G: Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol; 2008 Sep;134(9):969-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of bone: treatment and outcome of 214 cases.
  • BACKGROUND: Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study.
  • The effects of bone cement (PMMA), burring and hydrogen peroxide (H(2)O(2)) were statistically analyzed and the influence of a subchondral bone graft on the recurrence rate was evaluated.
  • If the tumor reaches close to the articulating surface a subchondral bone graft (n = 42) can be performed without risking a higher recurrence rate.
  • [MeSH-major] Bone Neoplasms / therapy. Giant Cell Tumor of Bone / therapy

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  • (PMID = 18322700.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 9011-14-7 / Polymethyl Methacrylate; BBX060AN9V / Hydrogen Peroxide
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48. Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology; 2009 Oct;55(4):432-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  • The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours.
  • METHODS AND RESULTS: This study analysed in situ expression in 25 malignant and 13 benign human bone and soft tissue tumours.
  • Among benign tumours, non-ossifying fibromas, desmoid tumours and chondroblastomas expressed both FAP and DPP-IV.
  • Giant cells expressed DPP-IV in giant cell tumours.
  • CONCLUSIONS: Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Dipeptidyl Peptidase 4 / metabolism. Gelatinases / metabolism. Membrane Proteins / metabolism. Serine Endopeptidases / metabolism. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • (PMID = 19817894.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / fibroblast activation protein alpha; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2784039
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49. Nnodu OE, Giwa SO, Eyesan SU, Abdulkareem FB: Fine needle aspiration cytology of bone tumours--the experience from the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria. Cytojournal; 2006;3:16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology of bone tumours--the experience from the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria.
  • BACKGROUND: Due to difficulty in confirming clinical suspicions of malignancy in patients presenting with bone tumours, the cost of surgical biopsies where hospital charges are borne almost entirely by patients, competition with bone setters and healing homes with high rate of loss to follow up; we set out to find if sufficient material could be obtained to arrive at reliable tissue diagnosis in patients with clinical and radiological evidence of bone tumours in our hospitals.
  • Aspirations were carried out with size 23G needles of varying lengths with 10 ml syringes in a syringe holder (CAMECO, Sebre Medical, Vellinge, Sweden).
  • RESULTS: Out of 96 patients evaluated, [57 males, 39 females, Mean age 31.52 years, Age Range 4-76 years,] material sufficient for diagnosis was obtained in 90 patients.
  • Cytological diagnosis of benign lesions was made in 40 patients and malignant in 47.
  • Of these, 27 were metastases, osteogenic sarcoma 16, giant cell tumour 19, infection 11.
  • Correct diagnosis of benignity was made in 17 out of 18 cases, malignancy in 21 out of 22 cases.
  • The accuracy of specific cytological diagnosis was 36/41 (87.8%) and incorrect in 5/41 (12.2%).
  • CONCLUSION: We conclude that FNAC can be useful in the pre-operative assessment of bone tumours especially where other diagnostic modalities are unavailable.

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  • [Cites] Acta Cytol. 1998 Jul-Aug;42(4):875-82 [9684571.001]
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  • (PMID = 16776844.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1526751
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50. Bello Báez A, López Pino MA, Azorín Cuadrillero D, Sirvent Cerdá S: [Aneurysmatic bone cyst coexisting with osteosarcoma. Radiopathologic discussion]. Radiologia; 2010 May-Jun;52(3):247-50
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  • [Title] [Aneurysmatic bone cyst coexisting with osteosarcoma. Radiopathologic discussion].
  • Aneurysmatic bone cysts are benign lesions of unknown origin.
  • It has been postulated that they might occur in reaction to trauma or to a primary benign (giant cell tumor, chondroblastoma, etc.) or malignant (osteosarcoma) bone tumor that results in local hemodynamic changes.
  • We present a case of low grade osteosarcoma with a radiologic progression that was indistinguishable from that of an aneurysmatic bone cyst.
  • [MeSH-major] Bone Cysts, Aneurysmal / radiography. Humerus. Osteosarcoma / radiography

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  • [Copyright] Copyright © 2009 SERAM. Published by Elsevier Espana. All rights reserved.
  • (PMID = 20304449.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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51. Panasiuk M, Iwański A: Diagnostic difficulties in pigmented villonodular synovitis. Presentation of cases. Ortop Traumatol Rehabil; 2008 Nov-Dec;10(6):613-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the literature, this condition has been called xanthoma, xanthogranuloma, villous arthritis, pigmented villonodular synovitis, xanthomatous giant cell tumour, giant cell tumour of tendon sheath, giant cell fibrohemangioma, benign synovioma.
  • [MeSH-major] Synovitis, Pigmented Villonodular / diagnosis. Synovitis, Pigmented Villonodular / surgery
  • [MeSH-minor] Adolescent. Ankle Joint. Diagnosis, Differential. Female. Giant Cell Tumor of Bone / diagnosis. Hemangioma / diagnosis. Humans. Knee Joint / blood supply. Magnetic Resonance Imaging. Middle Aged. Synovial Membrane / surgery. Terminology as Topic

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  • (PMID = 19153550.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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52. Eyichukwu GO, Ogugua PC: Osteoclastoma in an infant. Niger J Med; 2007 Oct-Dec;16(4):378-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoclastoma in an infant.
  • BACKGROUND: Conventionally, osteoclastoma is a benign but locally aggressive bone tumour with a tendency for local recurrence and rarely distant metastasis, diagnosed mainly in young adults, 15-40 years of age.
  • Diagnosis before skeletal maturity is circumspect.
  • We report a case of giant cell tumour of the clavicle (uncommon site) in a 2% year old girl that was first noticed at 6 months of age.
  • It rapidly increased in size to involve the entire clavicle with associated pain following manipulation by a traditional bone setter about 6 months after onset.
  • She had incisional biopsy; the histological report of which was osteoclastoma.
  • CONCLUSION: Osteoclastoma can develop in early childhood far before skeletal maturity, may be congenital in manifestation and can affect anybone in the body.
  • [MeSH-major] Clavicle / pathology. Giant Cell Tumor of Bone / pathology

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  • (PMID = 18080601.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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53. Jarkiewicz-Kochman E, Gołebiowski M, Swiatkowski J, Pacholec E, Rajewski R: Tumours of the metatarsus. Ortop Traumatol Rehabil; 2007 May-Jun;9(3):319-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Single cases of the following tumours have been discussed: giant cell tumour, metastases (lung, prostate gland), chondroblastoma, aneurysmal bone cyst, Ewing's sarcoma, clear cell carcinoma, osteosarcoma, intraosseous ganglion, chondromyxoid fibroma and granuloma.
  • The aim of the present study was to carry out a systematic examination of metatarsal tumours with regard to methods of diagnosis (location) and morphology.
  • RESULTS: Most of the metatarsal tumours were benign.
  • Bone tumours are rarely located in the metatarsus.
  • 4. The frequently unequivocal presentation of metatarsal tumours requires a multidisciplinary diagnosis involving a clinician, a radiologist and a histopathologist.
  • [MeSH-major] Bone Neoplasms / diagnosis. Metatarsal Bones / radiography
  • [MeSH-minor] Adult. Bone Cysts, Aneurysmal / diagnosis. Diagnosis, Differential. Female. Giant Cell Tumor of Bone / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Osteochondroma / diagnosis. Osteoma / diagnosis. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17721430.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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54. Chadha M, Agarwal A, Wadhwa N: Chondroid chordoma of the L5 spinous process and lamina: a case report. Eur Spine J; 2005 Oct;14(8):803-6
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  • Chordoma is a rare bone tumor that originates from the remnants of the notochord.
  • This paper reports a rare occurrence of a chordoma in the posterior elements of the L5 vertebra.
  • A differential diagnosis of a benign tumor (giant cell tumor, aneurysmal bone cyst or osteoblastoma) was made initially.
  • The tumor was removed enbloc.
  • Histopathological examination revealed the tumor mass to be chordoma.
  • [MeSH-major] Chordoma / pathology. Diagnosis, Differential. Lumbar Vertebrae / pathology

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  • [Cites] Spine (Phila Pa 1976). 2000 Oct 1;25(19):2537-40 [11013508.001]
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  • (PMID = 15895260.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3489257
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55. Kapoor SK, Jain V, Agrawal M, Singh S, Mandal AK: Primary malignant giant cell tumor of bone: a series of three rare cases. J Surg Orthop Adv; 2007;16(2):89-92
MedlinePlus Health Information. consumer health - Bone Cancer.

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  • [Title] Primary malignant giant cell tumor of bone: a series of three rare cases.
  • The purpose of this research was to study incidence; clinical, histological, and radiological features; and outcome of primary malignant giant cell tumor (PMGCT).
  • The authors retrospectively reviewed all cases of giant cell tumor (GCT) in which a diagnosis of GCT was related to sarcoma treated in their department between 1997 and 2004.
  • In these three cases of PMGCT, the initial clinical and radiological findings were the same as those for benign giant cell tumor.
  • Wide excision of the tumor was performed in all three cases.
  • Awareness about this entity, adequate biopsy, and sampling of specimen can aid in early diagnosis, which may improve the overall prognosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis

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  • (PMID = 17592717.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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56. Natarajan MV, Chandra Bose J, Viswanath J, Balasubramanian N, Sameer M: Custom prosthetic replacement for distal radial tumours. Int Orthop; 2009 Aug;33(4):1081-4
MedlinePlus Health Information. consumer health - Bone Cancer.

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  • We analysed the results of 24 cases of aggressive benign and malignant tumours of the distal radius treated by resection and prosthetic replacement between 1995 and 2006.
  • Recurrent giant cell tumour was the most common tumour.
  • The average Musculoskeletal Tumor Society (MSTS) functional score achieved was 75%.
  • [MeSH-major] Arthroplasty, Replacement / methods. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Osteosarcoma / surgery. Prostheses and Implants. Radius / surgery

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  • (PMID = 19242692.001).
  • [ISSN] 1432-5195
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899006
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57. Kumar Dutta H: Jaw and gum tumours in children. Pediatr Surg Int; 2009 Sep;25(9):781-4
MedlinePlus Health Information. consumer health - Jaw Injuries and Disorders.

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  • Two patients had aneurysmal bone cyst.
  • Melanotic neuroectodermal tumour of infancy was noted in two patients.
  • Ameloblastic fibrosis, another rare tumour in children, and non-osseus fibroma were noted in one patient each.
  • Excision of the mass was done in all except two patients with aneurysmal bone cyst, in whom curettage of the cyst was done.
  • CONCLUSION: Jaw and gum tumours in children are usually benign.
  • Excision of the tumour or curettage is curative in most of them.
  • [MeSH-minor] Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Child, Preschool. Curettage. Edema / etiology. Female. Fibroma / pathology. Fibroma / surgery. Follow-Up Studies. Granuloma, Giant Cell / pathology. Granuloma, Giant Cell / surgery. Humans. Infant. Infant, Newborn. Male. Neuroectodermal Tumor, Melanotic / pathology. Neuroectodermal Tumor, Melanotic / surgery. Pain / etiology. Retrospective Studies

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  • (PMID = 19669649.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Bianchi G, Staals EL, Donati D, Mercuri M: The use of unicondylar osteoarticular allografts in reconstructions around the knee. Knee; 2009 Jan;16(1):1-5
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  • Unicondylar osteoarticular allografts (UOA) of the knee are mainly used after bone tumour resections for benign aggressive tumours or small malignant tumours with clearly defined margins.
  • The diagnosis was chondrosarcoma in four cases, giant cell tumour in three, osteosarcoma in three, posttraumatic defect in one, and one failed UOA.
  • [MeSH-major] Bone Neoplasms / surgery. Transplantation, Homologous / methods

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  • (PMID = 18954989.001).
  • [ISSN] 0968-0160
  • [Journal-full-title] The Knee
  • [ISO-abbreviation] Knee
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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59. Peh WC, Koh WL, Kwek JW, Htoo MM, Tan PH: Imaging of painful solitary lesions of the sacrum. Australas Radiol; 2007 Dec;51(6):507-15
MedlinePlus Health Information. consumer health - Spine Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign lesions include giant cell tumour, neurogenic tumour, insufficiency fracture, infection and giant bone island.
  • Malignant lesions include primary bone tumours, Ewing sarcoma, plasmacytoma, lymphoma and chordoma.
  • [MeSH-major] Diagnostic Imaging. Sacrum / pathology. Spinal Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Soft Tissue Neoplasms / diagnosis. Spinal Fractures / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 17958684.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 19
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60. Altuntas AO, Slavin J, Smith PJ, Schlict SM, Powell GJ, Ngan S, Toner G, Choong PF: Accuracy of computed tomography guided core needle biopsy of musculoskeletal tumours. ANZ J Surg; 2005 Apr;75(4):187-91
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  • BACKGROUND: The accurate diagnosis of musculoskeletal tumours is important for successful treatment.
  • Image guided biopsy is gaining increasing acceptance for obtaining tissue for diagnosis.
  • METHODS: This is a retrospective study on a series of 127 patients with a musculoskeletal tumour.
  • The accuracy of the CT-guided core needle biopsy was determined by comparing the histology of the biopsy with the final histology of the specimen obtained at open biopsy or surgical resection of the tumour.
  • The effective accuracy was determined by the accuracy of the biopsy to distinguish between a benign and malignant tumour.
  • The effective accuracy as determined by a malignant versus benign lesion was 89%.
  • There were 86 malignant tumours with a biopsy accuracy of 81.4% and there were 41 benign tumours with a biopsy accuracy of 78%.
  • The positive predictive value (PPV) of a malignant tumour is 98.9% and the PPV of benign tumour 90.2%.
  • The most common tumours in this series were liposarcoma (n = 12), osteosarcoma (n = 11) and giant cell tumour (n = 11).
  • CONCLUSION: Computed tomography guided core needle biopsy is a safe and effective procedure that is important in the diagnosis and management of musculoskeletal tumours.
  • It should be performed in a specialized institution with a multidisciplinary musculoskeletal tumour team.
  • [MeSH-major] Biopsy, Needle / methods. Bone Neoplasms / pathology. Muscle Neoplasms / pathology. Surgery, Computer-Assisted. Tomography, X-Ray Computed

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  • (PMID = 15839962.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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61. Mayilvahanan N, Paraskumar M, Sivaseelam A, Natarajan S: Custom mega-prosthetic replacement for proximal humeral tumours. Int Orthop; 2006 Jun;30(3):158-62
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  • We used custom mega-prostheses in 57 patients with aggressive benign and malignant tumours of the proximal humerus.
  • The most common tumour was osteosarcoma, followed by giant cell tumour and chondrosarcoma.
  • We achieved extra-articular and wide resection margins in all primary malignant tumours and narrow margins in benign and metastatic tumours.
  • [MeSH-major] Bone Neoplasms / therapy. Bone Substitutes. Humerus / pathology. Prosthesis Design

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  • (PMID = 16565840.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Other-IDs] NLM/ PMC2532098
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62. Gerber S, Ollivier L, Leclère J, Vanel D, Missenard G, Brisse H, de Pinieux G, Neuenschwander S: Imaging of sacral tumours. Skeletal Radiol; 2008 Apr;37(4):277-89
MedlinePlus Health Information. consumer health - Diagnostic Imaging.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All components of the sacrum (bone, cartilage, bone marrow, meninges, nerves, notochord remnants, etc.) can give rise to benign or malignant tumours.
  • Bone metastases and intraosseous sites of haematological malignancies, lymphoma and multiple myeloma are the most frequent aetiologies, while primary bone tumours and meningeal or nerve tumours are less common.
  • Some histological types have a predilection for the sacrum, especially chordoma and giant cell tumour.
  • [MeSH-major] Diagnostic Imaging. Sacrum / pathology. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Contrast Media. Diagnosis, Differential. Humans. Imaging, Three-Dimensional. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / therapy

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  • (PMID = 18034341.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 45
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63. de Vries IA, van Acht MM, Demeyere T, Lybeert ML, de Zoete JP, Nieuwenhuijzen GA: Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature. Radiat Oncol; 2010;5:7
Genetic Alliance. consumer health - Castleman's Disease.

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  • BACKGROUND: Castleman disease (CD) is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body.
  • The etiology of this disorder is unclear, although the histopathological presentation can be differentiated into a hyaline vascular variant, a plasma cell variant and a mixed variant.
  • METHODS: Case report of a 67 year old woman.
  • RESULTS: This report, describes the case of a 67-year-old woman with unicentric Castleman disease located in the right lower abdomen.
  • Computed tomography (CT)- examination revealed a tumour, which had grown to form a close relationship with the common iliac vessels and the sacral bone.
  • A Laparotomy procedure revealed that the tumour was an irresectable mass.
  • Neo-adjuvant radiotherapy (40 Gy) was administered in order to downsize the tumour.
  • Six weeks later a new CT-scan revealed a major reduction of the tumour, which enabled a successful radical resection of the tumour to be performed.
  • Histopathological analysis of the tumour showed the hyaline vascular type of CD.
  • [MeSH-major] Giant Lymph Node Hyperplasia / radiotherapy. Neoadjuvant Therapy

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  • (PMID = 20122250.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Randomized Controlled Trial; Review
  • [Publication-country] England
  • [Number-of-references] 40
  • [Other-IDs] NLM/ PMC2827478
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64. Kind M, Stock N, Coindre JM: Histology and imaging of soft tissue sarcomas. Eur J Radiol; 2009 Oct;72(1):6-15
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  • Imaging and histology are two complementary morphological techniques which play a fundamental role in the diagnosis and management of soft tissue sarcomas.
  • Imaging allows to identify some pseudosarcomatous benign lesions such as myositis ossificans, intramuscular hemangioma, angiomyolipoma, intramuscular lipoma, giant cell tumour of tendon sheath, desmoid tumour and elastofibroma.
  • There is no formal criterion for diagnosing a sarcoma on magnetic resonance imaging (MRI) but malignancy is strongly suspected with the presence of necrosis and vascular, bone or joint invasion.
  • Imaging is also extremely helpful in determining the appropriate kind of sampling to carry out and in guiding the performance of a microbiopsy.
  • [MeSH-major] Diagnostic Imaging / methods. Muscle Neoplasms / diagnosis. Sarcoma / diagnosis

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  • (PMID = 19835758.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 19
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65. Buric N, Jovanovic G, Pesic Z, Krasic D, Radovanovic Z, Mihailovic D, Tijanic M: Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol; 2009 Mar;38(3):178-81
Genetic Alliance. consumer health - Schwannoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma is a benign nerve tumour that originates from Schwann cells, which cover peripheral nerves.
  • A rare case of intraosseous schwannoma is reported in a 23-year-old woman.
  • Radiographically, mandibular intraosseous schwannoma is difficult to differentiate from bone tumours such as ameloblastoma, myxoma, fibrous dysplasia, neurofibroma, central giant cell lesion or periapical lesion, so it should be included in the list of possible periapical pathoses.
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Molar / radiography. Radiography, Bitewing. S100 Proteins / analysis. Tooth Root / radiography. Tooth, Nonvital / radiography. Young Adult

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  • (PMID = 19225090.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins
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66. Zhang Q, Zhao H, Maheshwari AV, Cai L, Yu F, Niu X: Isolated cardiac metastasis from a histologically "benign" giant-cell tumor of the distal end of the femur: a case report. J Bone Joint Surg Am; 2010 Nov 17;92(16):2725-31
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated cardiac metastasis from a histologically "benign" giant-cell tumor of the distal end of the femur: a case report.
  • [MeSH-major] Bone Neoplasms / pathology. Femur / pathology. Giant Cell Tumor of Bone / secondary. Heart Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy, Needle. Disease Progression. Fatal Outcome. Heart Failure / diagnosis. Humans. Immunohistochemistry. Male. Neoplasm Staging. Orthopedic Procedures / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 21084583.001).
  • [ISSN] 1535-1386
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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