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Items 1 to 32 of about 32
1. Tiwari P, Tripathi A, Vijay M, Mitra B, Kumar S, Pal DK, Kundu AK: Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience. Indian J Cancer; 2010 Oct-Dec;47(4):418-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience.
  • AIMS: Inverted papilloma (IP) is an uncommon benign neoplasm of the urinary tract.
  • In this study, we review all cases of urinary bladder IP in our institution and determine the need for strict follow-up.
  • MATERIALS AND METHODS: We included consecutive patients from August 2004 to August 2008 with IP of the urinary bladder in this study who did not have prior or concurrent urothelial carcinoma.
  • No patient had a synchronous or previous bladder tumor.
  • All were solitary tumors except one, most commonly found at the bladder neck and trigone.
  • CONCLUSIONS: We conclude that when diagnosed by strictly defined criteria, IP as benign urothelial neoplasm was with extremely low incidence of recurrence and good prognosis.
  • It does not seem to be a risk factor for TCC, especially if located in the bladder.
  • [MeSH-major] Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 21131756.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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2. Sung MT, Eble JN, Wang M, Tan PH, Lopez-Beltran A, Cheng L: Inverted papilloma of the urinary bladder: a molecular genetic appraisal. Mod Pathol; 2006 Oct;19(10):1289-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inverted papilloma of the urinary bladder: a molecular genetic appraisal.
  • Inverted papilloma of urinary bladder is an uncommon urothelial neoplasm.
  • Little is known of the genetic abnormalities of inverted papilloma.
  • The monoclonal origin demonstrated in the study of X-chromosome inactivation indicates the clonal process of inverted papilloma; however, the low incidence of LOH supports the view that inverted papilloma in urinary bladder is a benign neoplasm with molecular genetic abnormalities different from those of urothelial carcinoma.
  • [MeSH-major] Loss of Heterozygosity. Microsatellite Repeats / genetics. Papilloma, Inverted / genetics. Urinary Bladder Neoplasms / genetics. X Chromosome Inactivation

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  • (PMID = 16862073.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Interferon-alpha; 0 / Receptors, Androgen; 0 / Tumor Suppressor Protein p53
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3. Sung MT, Maclennan GT, Lopez-Beltran A, Montironi R, Cheng L: Natural history of urothelial inverted papilloma. Cancer; 2006 Dec 1;107(11):2622-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of urothelial inverted papilloma.
  • BACKGROUND: Inverted urothelial papilloma is an uncommon urothelial neoplasm.
  • Although it is traditionally regarded as a benign tumor, conflicting data on multiplicity, recurrence rate, and association with urothelial carcinoma have left uncertainties concerning its biologic behavior.
  • METHODS: The authors analyzed the clinicopathological characteristics of 75 cases of inverted papilloma in the urinary tract without prior or concurrent urothelial carcinoma to determine its biologic behavior and prognosis, and to correlate these findings with surveillance strategies.
  • Inverted papillomas were located in the urinary bladder (67 cases), prostatic urethra (4 cases), and ureter (4 cases).
  • The majority of vesical tumors arose from the trigone or near the bladder neck.
  • In 1 case of vesical inverted papilloma, there was a recurrence.
  • CONCLUSIONS: Both the extremely low incidence of tumor recurrence (1%) and strikingly favorable prognosis suggest that inverted urothelial papilloma, when diagnosed according to strictly defined criteria, is a benign urothelial neoplasm not related to urothelial carcinoma.
  • Therefore, complete transurethral resection of inverted papilloma is adequate surgical therapy, and surveillance protocols as rigorous as those employed in the management of urothelial carcinoma seem unnecessary.
  • [MeSH-major] Papilloma, Inverted / pathology. Urologic Neoplasms / pathology

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 17078053.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Otto W, Denzinger S, Bertz S, Gaumann A, Wild PJ, Hartmann A, Stoehr R: No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer. Int J Cancer; 2009 Nov 1;125(9):2205-8
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  • [Title] No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer.
  • Mutations in the fibroblast growth factor receptor 3 (FGFR3) gene causing constitutive oncogenic protein activation have been shown to be frequent in papillary noninvasive bladder tumours and are associated with a low risk of progression and a favourable outcome.
  • FGFR3 alterations have also been found in benign urothelial papilloma and flat urothelial hyperplasia suggesting FGFR3 alterations as an early event in bladder tumorigenesis.
  • To date there is no data available on FGFR3 mutations in normal urothelium from patients with bladder cancer.
  • We therefore analysed 64 samples of histopathological unsuspicious normal urothelium from 38 patients with FGFR3 mutated bladder tumours and 15 samples of urothelium from patients (n = 15) without any urothelial malignancy as a control group.
  • FGFR3 analyses did not reveal any mutation in the urothelium from neither the control group nor the bladder cancer group.
  • These data suggest that mutations in the FGFR3 gene are not the earliest genetic alterations in bladder carcinogenesis and are associated with a hyperproliferative (hyperplastic) phenotype in the urothelium.
  • [MeSH-major] Mutation. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Urinary Bladder / metabolism. Urinary Bladder Neoplasms / genetics

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  • [Copyright] (c) 2009 UICC.
  • (PMID = 19621447.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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5. Wan Q, Luo JD, Cai SL, Shen BH, Zhao WP, Zhang ZG, Xie LP, Shen ZJ: [Inverted urothelial papilloma: report of 151 cases]. Zhonghua Wai Ke Za Zhi; 2005 Jan 15;43(2):105-7

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  • [Title] [Inverted urothelial papilloma: report of 151 cases].
  • OBJECTIVE: To investigate the clinical features, pathology, diagnosis and treatment of inverted urothelial papilloma.
  • METHODS: A total of 151 cases of urothelial inverted papilloma were analysed retrospectively.
  • The diagnosis could be established mainly by ultrasonic, intravenous urography, retrograde pyelography, cystoscope and pathology.
  • Among them, 7 cases who had the papilloma at upper urinary tract underwent nephroureterectomy except one.
  • One hundred and forty-four cases had the papilloma at low urinary tract, with 124 treated by transurethral bladder tumor resection (TURBT), among which 11 cases accompanying benign prostatic hyperplasia were treated by transurethral prostatic resection, 3 by transurethral resection of prostatic urethral tumor, 15 by partial cystectomy, 2 by total cystectomy.
  • CONCLUSIONS: Inverted urothelial papilloma is a benign tumor, which appears male predominant.
  • Most of the lesions are found in the bladder.
  • TURBT is the preferred treatment choice for inverted papilloma of the bladder.
  • [MeSH-major] Papilloma, Inverted / diagnosis. Papilloma, Inverted / surgery. Urologic Neoplasms / diagnosis. Urologic Neoplasms / surgery

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  • (PMID = 15771817.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Riesz P, Székely E, Törzsök P, Majoros A, Szendroi A, Dombovári P, Romics I: [Can inverted papilloma in urinary bladder be considered as a benign tumor]. Orv Hetil; 2010 Jan 17;151(3):92-5
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  • [Title] [Can inverted papilloma in urinary bladder be considered as a benign tumor].
  • Inverted papilloma of the urinary bladder is a rare entity.
  • They aimed to find out the rate of inverted papilloma recurrences, and transformations into malignant bladder cancer.
  • MATERIALS AND METHODS: Thirty patients with histologically proven inverted papilloma were followed after transurethral resection of bladder, which meant urine tests every three months, abdominal ultrasound and cystoscopy.
  • In one case, inverted papilloma and transitiocellular tumor (pTa G1) were detected.
  • In one patient, inverted papilloma was found by control cystoscopy after transurethral resection of bladder (pT1 G2) and local chemotherapy 15 months later.
  • CONCLUSIONS: Based on authors' experience, inverted papilloma of the urinary bladder is a benign lesion, but malignant changes or concomitant transitiocellular tumor may occur, thus follow-up is needed.
  • Although references are not standardized, authors suggest following patients with inverted papilloma as a primary (pTa G1) bladder cancer.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Papilloma, Inverted / pathology. Papilloma, Inverted / surgery. Precancerous Conditions / pathology. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / surgery

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  • (PMID = 20061266.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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7. Derouiche A, El Attat R, Kourda N, Ben Slama MR, Ben Jilali S, Ayed M: [Inverted papilloma of the bladder: diagnosis and course]. Prog Urol; 2006 Apr;16(2):160-2
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  • [Title] [Inverted papilloma of the bladder: diagnosis and course].
  • [Transliterated title] Le papillome inversé de la vessie: diagnostic et evolution.
  • OBJECTIVE: To analyse the diagnosis, treatment and clinical course of inverted papilloma of the bladder MATERIALS AND METHODS: Between January 1980 and January 2004, 12 patients with an inverted papilloma of the bladder were included, representing 0.36% of all bladder tumours treated over the same period.
  • The most frequent presenting complaint was macroscopic haematuria (10/12 cases), associated with signs of bladder irritation in 8 cases.
  • CONCLUSION: Inverted papillomas of the bladder are rare, benign tumours that can be associated with urothelial carcinoma, requiring rigorous surveillance.
  • [MeSH-major] Papilloma, Inverted / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 16734238.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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8. Fu TY, Tu MS, Tseng HH, Wang JS: Overexpression of p27kip1 in urinary bladder urothelial carcinoma. Int J Urol; 2007 Dec;14(12):1084-7
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  • [Title] Overexpression of p27kip1 in urinary bladder urothelial carcinoma.
  • This study investigated the expression of proliferative cell nuclear antigen (PCNA), p53, Rb, p27(kip1), and cyclin D1 by immunostains in bladder tumors, especially urothelial papilloma, papillary urothelial neoplasm of low malignant potential, and low and high grade urothelial carcinoma, to see if their expression is associated with classification or grading of the urinary bladder urothelial carcinoma.
  • METHOD: Nuclear expression of PCNA, p53, Rb, p27(kip1), and cyclin D1 was determined immunohistochemically in a series of 89 urinary bladder tumor specimens, including 13 papilloma, 15 urothelial neoplasm of low malignant potential, 17 low grade urothelial carcinoma, and 44 high grade urothelial carcinoma.
  • There was no significant difference in cyclinD1, Rb and PCNA expression between benign, low malignant potential and urothelial carcinoma.
  • CONCLUSION: We first noted an overexpression of p27(kip1) in urinary bladder urothelial carcinoma.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Intracellular Signaling Peptides and Proteins / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18036045.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Cyclin D; 0 / Cyclins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Proliferating Cell Nuclear Antigen; 0 / Retinoblastoma Protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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9. Yu J, Sun ZX, Kong CZ, Du SQ: [The clinical analysis of 62 cases of the urothelial inverted papilloma]. Zhonghua Wai Ke Za Zhi; 2009 Sep 15;47(18):1400-2

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  • [Title] [The clinical analysis of 62 cases of the urothelial inverted papilloma].
  • OBJECTIVE: To investigate the clinical manifestation, biological behavior, diagnosis and treatment of the urothelial inverted papilloma.
  • METHODS: Sixty-two cases of urothelial inverted papilloma were analyzed retrospectively from January 1990 to August 2008.
  • One case of multiple ureteral inverted papilloma with coexistent bladder inverted papilloma was treated by total cystectomy.
  • The tumor located at the bladder in 52 cases, with 44 treated by transurethral resection of bladder tumor, 6 by partial cystectomy, 2 by total cystectomy.
  • RESULTS: The postoperative pathological diagnosis of all the 62 cases was inverted papilloma, synchronous urothelial carcinoma in 7.
  • CONCLUSIONS: Inverted urothelial papilloma is a kind of benign tumor.
  • [MeSH-major] Papilloma, Inverted / surgery. Urologic Neoplasms / surgery

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  • (PMID = 20092776.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Lee SH, Mah SY, Chung BH: Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms. J Endourol; 2010 Feb;24(2):271-5
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  • [Title] Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms.
  • BACKGROUND AND PURPOSE: Inverted urothelial papilloma (IP) is an uncommon urothelial neoplasm.
  • We aimed to determine the clinicopathologic characteristics of IP of the bladder and its association with prostate volume and lower urinary tract symptoms (LUTS).
  • PATIENTS AND METHODS: From 1994 to 2008, 53 patients with urinary IP underwent transurethral resection of the bladder tumor (TURBT) at our institution.
  • We reviewed the clinicopathologic characteristics of IP of the bladder and its association with prostate volume and LUTS.
  • In IP located on the bladder neck of patients with benign prostatic hyperplasia (BPH), significantly higher obstructive symptoms and larger prostate volumes than that of other located IP with BPH were observed.
  • CONCLUSIONS: This is the largest series of cases of urinary bladder IP reported from Korea.
  • Despite the absence of agreement of its etiology, its presenting symptoms were related to LUTS and benign prostatic enlargement.

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  • (PMID = 20039831.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Albores-Saavedra J, Chable-Montero F, Hernández-Rodríguez OX, Montante-Montes de Oca D, Angeles-Angeles A: Inverted urothelial papilloma of the urinary bladder with focal papillary pattern: a previously undescribed feature. Ann Diagn Pathol; 2009 Jun;13(3):158-61
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  • [Title] Inverted urothelial papilloma of the urinary bladder with focal papillary pattern: a previously undescribed feature.
  • However, the papillary fronds were similar to those of exophytic urothelial papilloma.
  • The recognition of papillary structures in urothelial inverted papilloma broadens the morphological spectrum of this unusual benign urothelial neoplasm and complicates the microscopic interpretation of urothelial lesions with inverted growth patterns.
  • Surgical pathologists should be aware of this unusual feature of inverted urothelial papilloma of the urinary bladder to avoid misinterpretation with urothelial carcinoma with an inverted pattern.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19433293.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ho H, Chen YD, Tan PH, Wang M, Lau WK, Cheng C: Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience. Urology; 2006 Aug;68(2):333-6
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  • [Title] Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience.
  • OBJECTIVES: To review all cases of urinary bladder inverted papilloma (IP) in our institution and determine the need for cystoscopic surveillance.
  • IP is an uncommon benign tumor of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • Ten cases were incidental findings during bladder ultrasonography or cystoscopy.
  • All were solitary tumors, most commonly found at the bladder neck.
  • CONCLUSIONS: Although our cases exhibited benign biologic behavior, the presence of cytologic atypia and suspicious urine cytology require exclusion of TCC with an inverted pattern.
  • Thus, in histologically proven solitary bladder IP with no associated TCC, cystoscopic surveillance may not be necessary.
  • [MeSH-major] Cystoscopy. Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16904447.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Ferrero Doria R, Huertas Valero E, Coronel Sánchez B, Moreno Pérez F, García Víctor F, Díaz Calleja E: [Inverted papilloma of the upper urinary tract]. Actas Urol Esp; 2005 Apr;29(4):423-6

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  • [Title] [Inverted papilloma of the upper urinary tract].
  • [Transliterated title] Papiloma invertido de tracto urinario superior.
  • Inverted papilloma of the upper urinary tract is a rare tumor and generally considered to be a benign.
  • We present two cases of benign ureteral inverted papilloma.
  • Both cases appear to be associated with asynchronous and synchronous bladder carcinoma, so it is very important a strict follow-up.
  • [MeSH-major] Papilloma, Inverted / pathology. Ureteral Neoplasms / pathology

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  • (PMID = 15981434.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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14. Thomas G, Gera P, Arbuckle S, Cohen R: Transitional cell papilloma of the bladder in a child: a case report and review of literature. J Pediatr Urol; 2006 Feb;2(1):59-62

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  • [Title] Transitional cell papilloma of the bladder in a child: a case report and review of literature.
  • Transitional cell papillomas of the bladder are tumours of epithelial origin that are extremely rare in children.
  • They are benign and endoscopic excision has been considered curative; however, the rate of recurrence reported in the literature is fairly high, with the earliest recurrence being at 3 months.

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  • (PMID = 18947598.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Gould VE, Schmitt M, Vinokurova S, Reddy VB, Bitterman P, Alonso A, Gattuso P: Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder. Cancer Lett; 2010 Jun 28;292(2):171-5
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  • [Title] Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder.
  • Human Papillomaviruses (HPVs) have been found in association with benign and malignant growth of epithelia.
  • Inverted papillomas of the urinary bladder are epithelial tumors considered to be of benign nature.
  • In this report we analyze the expression of p16(Ink4a) and the presence of HPV sequences in inverted papillomas and in non-tumoral bladder controls.
  • We conclude that HPV does not play an indispensable role in the development of urinary bladder inverted papillomas and that overexpression of p16(Ink4a) does not correlate with HPV infection in these tumors.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Papilloma / metabolism. Papilloma / virology. Urinary Bladder Neoplasms / metabolism. Urinary Bladder Neoplasms / virology

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20036459.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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16. Mamoon N, Iqbal MA, Jamal S, Luqman M: Urothelial neoplasia of the urinary bladder--comparison of interobserver variability for WHO Classification 1972 with WHO/ISUP Consensus Classification 1998. J Ayub Med Coll Abbottabad; 2006 Apr-Jun;18(2):4-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urothelial neoplasia of the urinary bladder--comparison of interobserver variability for WHO Classification 1972 with WHO/ISUP Consensus Classification 1998.
  • BACKGROUND: Classification of urothelial bladder tumours is an important factor in the treatment and prognosis of these lesions.
  • The objective of this study was to classify urothelial neoplasms of the urinary bladder using the latest WHO/ISUP Consensus Classification 1998 and WHO Classification 1972 and compare the two regarding interobserver variability.
  • METHODS: This study included 100 consecutive biopsy specimens of urothelial neoplasms of the urinary bladder diagnosed at the department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi.
  • The tumour categories for WHO classification 1972; papilloma, and transitional cell carcinoma (TCC) grades I, II and III were compared with the WHO/ISUP Consensus Classification entities of papilloma, papillary neoplasm of low malignant potential, low grade and high grade papillary carcinomas.
  • Kappa values were less for benign and borderline lesions using both systems.
  • CONCLUSIONS: WHO/ISUP Consensus Classification 1998 showed less interobserver variability than WHO Classification 1972 in the evaluation of bladder tumours.
  • There was less agreement on the benign and borderline lesions using both the classifications.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology

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  • (PMID = 16977804.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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17. Lopez-Beltran A: Bladder cancer: clinical and pathological profile. Scand J Urol Nephrol Suppl; 2008 Sep;(218):95-109
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bladder cancer: clinical and pathological profile.
  • Bladder tumours represent a heterogeneous group of cancers.
  • The natural history of these bladder cancers is that of recurrence of disease and progression to higher grade and stage disease.
  • Furthermore, recurrence and progression rates of superficial bladder cancer vary according to several tumour characteristics, mainly tumour grade and stage.
  • The papillary lesions are broadly subdivided into benign (papilloma and inverted papilloma), papillary urothelial neoplasia of low malignant potential (PUNLMP) and non-invasive papillary carcinoma (low or high grade).
  • This article summarizes the recent literature concerning important issues in the pathology and the clinical management of patients with bladder urothelial carcinoma.
  • Emphasis is placed on clinical presentation, the significance of haematuria, macroscopic appearance (papillary, solid or mixed, single or multiple) and synchronous or metachronous presentation (field disease vs monoclonal disease with seeding), classification and microscopic variations of bladder cancer with clinical significance, TNM distribution and the pathological grading according to the 2004 WHO proposal.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology

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  • (PMID = 18815924.001).
  • [ISSN] 0300-8886
  • [Journal-full-title] Scandinavian journal of urology and nephrology. Supplementum
  • [ISO-abbreviation] Scand J Urol Nephrol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Sweden
  • [Number-of-references] 100
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18. Romih R, Korosec P, Sedmak B, Jezernik K: Mitochondrial localization of nitric oxide synthase in partially differentiated urothelial cells of urinary bladder lesions. Appl Immunohistochem Mol Morphol; 2008 May;16(3):239-45
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  • [Title] Mitochondrial localization of nitric oxide synthase in partially differentiated urothelial cells of urinary bladder lesions.
  • Because diseases influence the expression of uroplakins, the main urothelial differentiation-related proteins, we compared their expression and localization with that of inducible NOS (iNOS) in bladder outlet obstruction caused by benign prostatic hyperplasia and in noninvasive urothelial neoplasms (papilloma, low-grade, and high-grade papillary carcinoma).
  • These results suggest that various urinary bladder lesions alter the normal differentiation pathway of urothelial superficial cells, which induces the expression of NOS in mitochondria of partially differentiated cells.

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  • (PMID = 18301246.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.13.39 / Nitric Oxide Synthase Type II
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19. Tong GX, Yee H, Chiriboga L, Hernandez O, Waisman J: Fascin-1 expression in papillary and invasive urothelial carcinomas of the urinary bladder. Hum Pathol; 2005 Jul;36(7):741-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fascin-1 expression in papillary and invasive urothelial carcinomas of the urinary bladder.
  • We found no report on the role or the protein expression of fascin-1 in urothelial carcinomas (UCs) of the urinary bladder.
  • In this study, we examined by immunohistochemistry the expression of fascin-1 in the normal human transitional epithelium, benign vesical lesions, and different types of UCs.
  • There was no increase of fascin-1 expression in cystitis cystica, cystitis glandularis, nephrogenic adenoma (n = 10), inverted papilloma (n = 5), and classic exophytic papilloma (n = 4) or in adjacent transitional epithelia associated with these conditions.
  • These findings suggest an association between increased fascin-1 expression and increased invasiveness of carcinomas in the urinary bladder.
  • [MeSH-major] Carcinoma, Papillary / metabolism. Carcinoma, Transitional Cell / metabolism. Carrier Proteins / metabolism. Microfilament Proteins / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 16084942.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / FSCN1 protein, human; 0 / Microfilament Proteins
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20. Fine SW, Epstein JI: Inverted urothelial papillomas with foamy or vacuolated cytoplasm. Hum Pathol; 2006 Dec;37(12):1577-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inverted papillomas of the bladder are uncommon benign neoplasms characterized by endophytic growth of urothelial cells as anastomosing cords, displaying minimal cytologic atypia.
  • Reports of inverted papilloma associated with urothelial carcinoma or urothelial carcinoma arising within inverted papilloma highlight the difficulties in evaluating urothelial lesions with inverted growth patterns.
  • Within the spectrum of findings in inverted papilloma, vacuolization and foamy (xanthomatous-appearing) cytoplasmic changes have not been previously reported.
  • In the current study, we present 5 novel cases of inverted papilloma involving 2 men and 3 women ranging in age from 48 to 88 years, who presented with microhematuria (n = 3) or irritative symptoms (n = 2).
  • Cystoscopically, the lesions were polypoid (n = 3), pedunculated (n = 1), or solid (n = 1), measured between 0.7 and 2.5 cm, and were all located at the trigone or bladder neck.
  • Morphologically, all cases had some component of usual inverted papilloma along with areas displaying foamy or vacuolated cytoplasm encompassing 30% to 90% of the lesion.
  • These "clear cells" were seen both in distinct regions within the biopsy and, more frequently, intermingled with usual inverted papilloma cells.
  • The diagnostic dilemma encountered in these cases of inverted papilloma with foamy or vacuolated cytoplasm warrants their distinction from other benign and malignant urothelial lesions with inverted growth and/or clear cell features.
  • [MeSH-major] Cytoplasm / ultrastructure. Papilloma, Inverted / ultrastructure. Urinary Bladder Neoplasms / ultrastructure. Urothelium / ultrastructure

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  • (PMID = 16949916.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Fine SW, Chan TY, Epstein JI: Inverted papillomas of the prostatic urethra. Am J Surg Pathol; 2006 Aug;30(8):975-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inverted papillomas of the genitourinary tract are uncommon benign neoplasms usually occurring in the urinary bladder and less frequently in the upper urinary tract.
  • To date, there are scant data and no comprehensive studies of inverted papilloma originating in the prostatic urethra.
  • Patients had a mean age of 65.1 years (range: 30 to 89 y), with 10/21 (47.6%) presenting with gross hematuria (n = 8) or irritative symptoms (n = 2) related to the inverted papilloma and 11/21 (52.4%) detected incidentally during work-up/treatment of prostate cancer (n = 6) or benign prostatic hypertrophy (BPH) (n = 5).
  • Histologically, 14/21 cases (67%) displayed classic inverted papilloma architecture.
  • The remaining cases showed foci of squamous metaplasia with moderate atypia (n = 4), rare true papillary fronds in a classic inverted papilloma background (n = 2), or both (n = 1).
  • Eleven cases with prostatic tissue revealed adenocarcinoma of the prostate [n = 6; Gleason score 6 (n = 3) or 7 (n = 3)], high-grade prostatic intraepithelial neoplasia (n = 1), benign prostatic hypertrophy (n = 3), or adenosis (n = 1).
  • No patients had a prior history of either inverted papilloma or urothelial carcinoma, whereas 2 patients were diagnosed with high-grade urothelial carcinoma of the bladder synchronous with their inverted papilloma diagnosis.
  • Only 1 of the 18 patients with available follow-up had a recurrence of inverted papilloma in the prostatic urethra.
  • Inverted papillomas of the prostatic urethra are benign lesions that are commonly detected incidentally and are not associated with a history of urothelial malignancy.
  • Although urothelial carcinoma elsewhere in the genitourinary tract may occur simultaneously, malignant transformation or recurrence as a malignant lesion has not been identified in inverted papilloma of the prostatic urethra.
  • [MeSH-major] Papilloma, Inverted / pathology. Prostate / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Humans. Incidental Findings. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Prognosis. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16861968.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Kilciler M, Bedir S, Erdemir F, Ors O, Kibar Y, Dayanc M: Evaluation of urinary inverted papillomas: a report of 13 cases and literature review. Kaohsiung J Med Sci; 2008 Jan;24(1):25-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inverted papilloma (IP) of the urothelium accounts for 2.2% of urothelial neoplasms.
  • The site of development was the bladder in 12 cases (92%) and ureter in one (8%) case.
  • Transurethral bladder tumor resection was performed in 12 cases.
  • IPs of the urinary bladder are benign tumors that can be treated successfully by transurethral resection and fulguration of the tumor bed.
  • [MeSH-major] Papilloma / pathology. Ureteral Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18218566.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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23. Dzombeta T, Krajacić-Jagarcec G, Tomas D, Kraus O, Ruzić B, Kruslin B: [Urothelial carcinoma with an inverted growth pattern: a report of 4 cases]. Acta Med Croatica; 2010 Mar;64(1):47-50
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  • AIM: Urothelial (transitional cell) tumors account for about 90% of all bladder tumors.
  • Their presentation varies from benign lesions that rarely recur to highly malignant tumors.
  • Inverted (endophytic) growth pattern in urothelial carcinoma is particulary hard to distinguish from inverted papilloma.
  • CONCLUSION: Urothelial carcinoma with inverted growth pattern and inverted papilloma have similar morphologic features but their biological behaviour, treatment and prognosis are different.
  • In order to avoid the urothelial carcinoma to be misdiagnosed as a benign papilloma, we find it very important to make additional investigations beside conventional histology.
  • Immunohistochemical staining for CK 20, p53 and Ki-67, which is positive in most carcinomas, can help us make the right diagnosis.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Papilloma, Inverted / pathology. Prognosis

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  • (PMID = 20653125.001).
  • [ISSN] 1330-0164
  • [Journal-full-title] Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti
  • [ISO-abbreviation] Acta Med Croatica
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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24. White SM, Graham JM Jr, Kerr B, Gripp K, Weksberg R, Cytrynbaum C, Reeder JL, Stewart FJ, Edwards M, Wilson M, Bankier A: The adult phenotype in Costello syndrome. Am J Med Genet A; 2005 Jul 15;136(2):128-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two patients in this series have had bladder carcinoma, the only malignancy reported to affect adults with Costello syndrome.
  • Benign tumors included multiple ductal papillomata in two women, and a fourth ventricle mass in one man, thought to be a choroid plexus papilloma.
  • Screening for microscopic hematuria as a marker for bladder carcinoma may be indicated, although this requires further evaluation.
  • [MeSH-minor] Adolescent. Adult. Arnold-Chiari Malformation / pathology. Developmental Disabilities / pathology. Female. Gastroesophageal Reflux / pathology. Growth Disorders / pathology. Heart Defects, Congenital / pathology. Humans. Male. Osteoporosis / pathology. Papilloma / pathology. Puberty, Delayed / pathology. Syndrome. Urinary Bladder Neoplasms / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • [ErratumIn] Am J Med Genet A. 2005 Nov 15;139(1):55
  • (PMID = 15940703.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM08243; United States / NICHD NIH HHS / HD / HD22657-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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25. Lopez-Beltran A, Cheng L: Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications. Hum Pathol; 2006 Nov;37(11):1371-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications.
  • It is important for surgical pathologists to be aware of these morphological variants that, on occasion, may lead to misinterpretation as benign.
  • In this article, we review the most common histologic variants of urothelial carcinoma of the bladder.
  • Emphasis is placed on clinical significance and differential diagnosis.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Large Cell / pathology. Carcinoma, Papillary / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Choriocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Lymphoma / pathology. Male. Mesothelioma / pathology. Middle Aged. Papilloma, Inverted / pathology. Paraganglioma / pathology. Plasmacytoma / pathology. Sarcoma / pathology. Urothelium

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  • (PMID = 16949919.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 107
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26. Dhall D, Al-Ahmadie H, Olgac S: Nested variant of urothelial carcinoma. Arch Pathol Lab Med; 2007 Nov;131(11):1725-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Due to the cells' deceptively bland appearance, the tumors are sometimes misdiagnosed as benign lesions, leading in some cases to a significant delay in establishing the correct diagnosis and thus contributing to this neoplasm's advanced stage.
  • Nested variant of urothelial carcinoma must be differentiated from the benign proliferative lesions of urothelium, such as von Brunn nests, cystitis cystica, cystitis glandularis, nephrogenic adenoma, inverted papilloma, and paraganglioma.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Urinary Bladder Neoplasms / pathology. Urothelium / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Humans. Keratin-20 / metabolism. Keratin-7 / metabolism. Middle Aged

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  • (PMID = 17979494.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
  • [Number-of-references] 14
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27. van der Kwast TH: How to combine the molecular profile with the clinicopathological profile of urothelial neoplastic lesions. Scand J Urol Nephrol Suppl; 2008 Sep;(218):175-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Regarding urothelial papilloma, clinical and limited molecular-genetic data seem to suggest that they may not represent a precursor lesion for bladder cancer.
  • It is more likely that urothelial papilloma is a benign neoplasm sharing mutations in the fibroblast growth factor-3 gene with seborrhoeic keratosis, allegedly its epidermal counterpart.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Transitional Cell / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18815932.001).
  • [ISSN] 0300-8886
  • [Journal-full-title] Scandinavian journal of urology and nephrology. Supplementum
  • [ISO-abbreviation] Scand J Urol Nephrol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers
  • [Number-of-references] 57
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28. Bernard-Pierrot I, Brams A, Dunois-Lardé C, Caillault A, Diez de Medina SG, Cappellen D, Graff G, Thiery JP, Chopin D, Ricol D, Radvanyi F: Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis; 2006 Apr;27(4):740-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surprisingly, identical somatic activating mutations have been found at the somatic level in tumours: at high frequency in benign epithelial tumours (seborrheic keratosis, urothelial papilloma) and in low-grade, low-stage urothelial carcinomas, and at a lower frequency in other types of urothelial carcinoma, in cervix carcinoma, and in haematological cancer, multiple myeloma.
  • Although mutated FGFR3b is mostly found in benign epithelial tumours or carcinomas of low malignant potential, we present evidence here that mutated FGFR3b is oncogenic.
  • All bladder tumours presenting FGFR3 mutations expressed this receptor more strongly than normal urothelium or non-mutated tumours.
  • NIH-3T3 cells transfected with a mutated form of FGFR3b--FGFR3b-S249C, the most common mutation in bladder tumours--presented a spindle-cell morphology, grew in soft agar and gave rise to tumours when xenografted into nude mice.
  • We identified one line of 17 bladder cell lines tested (MGH-U3) that expressed a mutated form of FGFR3b, FGFR3b-Y375C.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Urinary Bladder Neoplasms / genetics

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  • (PMID = 16338952.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Pyrroles; 0 / RNA, Small Interfering; 0 / SU 5402; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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29. Tannehill-Gregg SH, Sanderson TP, Minnema D, Voelker R, Ulland B, Cohen SM, Arnold LL, Schilling BE, Waites CR, Dominick MA: Rodent carcinogenicity profile of the antidiabetic dual PPAR alpha and gamma agonist muraglitazar. Toxicol Sci; 2007 Jul;98(1):258-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign gallbladder adenomas occurred at low incidences in male mice at 20 and 40 mg/kg (area under the curve [AUC] exposures > or = 62 times human exposure at 5 mg/day) and were considered drug related due to an increased incidence of gallbladder mucosal hyperplasia at these doses.
  • There was a dose-related increased incidence of transitional cell papilloma and carcinoma of the urinary bladder in male rats at 5, 30, and 50 mg/kg (AUC exposures > or = 8 times human exposure at 5 mg/day).
  • At 30 and 50 mg/kg, the urinary bladder tumors were accompanied by evidence of increased urine solids.
  • Subsequent investigative studies established that the urinary bladder carcinogenic effect was mediated by urolithiasis rather than a direct pharmacologic effect on urothelium.
  • Considering that muraglitazar is nongenotoxic, the observed tumorigenic effects in mice and rats have no established clinical relevance since they occurred at either clinically nonrelevant exposures (gallbladder and adipose tumors) or by a species-specific mechanism (urinary bladder tumors).

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  • (PMID = 17426106.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Hypoglycemic Agents; 0 / Oxazoles; 0 / PPAR alpha; 0 / PPAR gamma; TE7660XO1C / Glycine; W1MKM70WQI / muraglitazar
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30. Sow M, Nkégoum B, Oyono JL, Garoua, Nzokou A: [Epidemiological and histological features of urogenital tumours in Cameroon]. Prog Urol; 2006 Feb;16(1):36-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: A total of 2,371 urogenital tumours were identified, corresponding to 520 prostatic adenocarcinomas, 1,066 cases of benign prostatic hyperplasia, 41 testicular tumours (9 seminomatous tumours, 7 non-seminomatous tumours, 18 lymphomas, 4 benign papillomas and 2 rhabdomyosarcomas of the spermatic cord), 169 bladder tumours (25 transitional cell carcinomas, 70 squamous cell carcinomas, 67 adenocarcinomas, 2 lymphomas, 1 sarcoma and 1 benign papilloma), and 136 kidney tumours (20 Wilms tumours, 87 renal cell carcinomas, 6 transitional cell carcinomas, 16 lymphomas, 2 other malignant tumours and 5 adenomas).

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  • (PMID = 16526537.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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31. Lane Z, Epstein JI: Polypoid/papillary cystitis: a series of 41 cases misdiagnosed as papillary urothelial neoplasia. Am J Surg Pathol; 2008 May;32(5):758-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Polypoid cystitis and its more chronic phase papillary cystitis, which results as a reaction to injury to the bladder mucosa, is a benign lesion mimicking various papillary urothelial neoplasms.
  • For cases where information was available, clinical symptoms included bladder obstruction (n=7), gross hematuria (n=6), colovesicular fistula (n=4), follow-up status posttreatment of bladder and ureter carcinoma (n=4), bladder/urethral stones (n=2), benign prostate hyperplasia (n=2), follow-up after radiation for prostate cancer (n=2), long-standing urinary stents (n=2), and voiding dysfunction (n=1).
  • Original diagnoses included noninvasive low grade papillary urothelial carcinoma (n=23), noninvasive high grade papillary urothelial carcinoma (n=6), papillary urothelial neoplasm of low malignant potential (n=5), papilloma (n=3), urothelial neoplasia (n=2), carcinoma in situ (n=1), and squamous carcinoma (n=1).
  • The mean age at diagnosis was 63 years (range, 19 to 93 y; median 63 y).
  • Clinical symptoms varied with the most common manifestations, including gross hematuria, bladder/urethral stones, history of prostate cancer treated with radiation, follow-up after bladder/ureter carcinoma treatment, long-term urinary stents, and colovesicular fistulas.
  • The locations of polypoid cystitis were bladder (n=34), ureteral orifice (n=2), urethra (n=2), renal pelvis (n=2), and undesignated (n=1).
  • In cases where the diagnosis of papillary neoplasia is not straightforward and there is a question of polypoid cystitis, pathologists should seek clinical history that might suggest a reactive process.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Cystitis / diagnosis. Polyps / diagnosis. Urologic Neoplasms / diagnosis. Urothelium / pathology

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  • (PMID = 18379418.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Auber F, Jeanpierre C, Denamur E, Jaubert F, Schleiermacher G, Patte C, Cabrol S, Leverger G, Nihoul-Fékété C, Sarnacki S: Management of Wilms tumors in Drash and Frasier syndromes. Pediatr Blood Cancer; 2009 Jan;52(1):55-9
MedlinePlus Health Information. consumer health - Wilms Tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: We identified 20 patients, of whom 18 had benign or malignant tumors.
  • Median age at Wilms tumor diagnosis was 9 months.
  • Other tumors included three gonadoblastomas (in two patients), one retroperitoneal soft-tissue tumor, and one transitional cell papilloma of the bladder.
  • CONCLUSION: Most Wilms tumors in children with WT1-related disorders were early-stage and intermediate-risk tumors, with a young age at diagnosis.

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  • (PMID = 18816692.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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