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1. Sato N, Mizumoto K, Nagai E, Tanaka M: Telomerase as a new target for pancreatic cancer treatment. J Hepatobiliary Pancreat Surg; 2002;9(3):322-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • (1) telomerase activity has been found in a majority of human cancers, whereas most benign diseases and normal tissues do not express this enzyme;.
  • On the other hand, several issues still need to be addressed before these drugs are moved into clinical trials.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / enzymology. Antineoplastic Agents / therapeutic use. Enzyme Inhibitors / therapeutic use. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / enzymology. Telomerase / antagonists & inhibitors. Telomerase / metabolism
  • [MeSH-minor] Cell Death. Cell Division. DNA-Binding Proteins. Humans. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 12353143.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA-Binding Proteins; 0 / Enzyme Inhibitors; EC 2.7.7.49 / Telomerase
  • [Number-of-references] 79
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2. Hohmann J, Loddenkemper C, Albrecht T: Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents. Ultraschall Med; 2009 Apr;30(2):185-8
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  • [Title] Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents.
  • Low-MI contrast-enhanced ultrasound (CEUS) with SonoVue (Bracco, Milano, Italy) showed an enhancement pattern which was typical for benign liver lesions while high-MI CEUS with Levovist (Schering, Berlin, Germany) revealed a contrast defect in the liver late phase (4:30 min p. i.) which is typical for a malignant lesion.
  • Histology showed a benign biliary hamartoma and incomplete cirrhosis.
  • The findings confirmed that liver-specific contrast agents have the ability to detect very small focal liver lesions not derived from hepatic tissue but may lead to a misinterpretation as a malignant lesion.
  • Nevertheless biliary duct adenomas are benign lesions with almost the same perfusion properties as normal liver parenchyma.
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Esophageal Neoplasms / pathology. Esophageal Neoplasms / ultrasonography. Humans. Incidental Findings. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / ultrasonography. Male. Middle Aged. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 18726842.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / Polysaccharides; 0 / contrast agent BR1; 127279-08-7 / SHU 508; WS7LR3I1D6 / Sulfur Hexafluoride
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3. Ba-Ssalamah A, Fakhrai N, Matzek WK, Herneth AM, Stadler A, Bastati N, Herold CJ, Schima W: Magnetic resonance imaging of liver malignancies. Top Magn Reson Imaging; 2007 Dec;18(6):445-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histological structure of the liver is complex, consisting of hepatocytes, biliary epithelium, and mesenchymal cells.
  • From this large variety of cells, a broad spectrum of benign and malignant liver lesions in originate.
  • With the recent developments in hardware and software, magnetic resonance imaging (MRI) has emerged as the method of choice in the diagnostic workup of focal liver lesions, in particular in the pretherapeutic stage.
  • The introduction of high-field MRI at 3.0 T in the routine workup and the selective use of liver-specific contrast agents, including hepatobiliary and reticuloendothelial agents, have also strengthened the role of MRI in liver imaging.
  • In this overview article, we will review the recent developments in 3.0-T MRI and MRI contrast agents in the diagnostic workup of the most common malignant liver tumors.
  • [MeSH-minor] Contrast Media. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Staging

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  • (PMID = 18303402.001).
  • [ISSN] 0899-3459
  • [Journal-full-title] Topics in magnetic resonance imaging : TMRI
  • [ISO-abbreviation] Top Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 64
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4. Iglesias-García J: [Pancreatic tumors]. Gastroenterol Hepatol; 2008 Oct;31 Suppl 4:83-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among the diagnostic options, endoscopic ultrasound (EUS) continues to be developed, with the use of elastography, contrast agents and EUS-guided aspiration and the application of technical improvements that increase diagnostic efficacy (such as the use of specific stains, new aspiration needles, etc.).
  • Notable in the field of palliative treatment is the development of new biliary stents that aim to reduce obstruction rates.
  • The development of EUS and EUS-guided fine-needle aspiration has been crucial in cystic pancreatic tumors, especially in distinguishing benign from malignant lesions or those with potential for malignant transformation (presence of mural modules, dilatation of the main pancreatic duct, the presence of masses, CEA levels, etc.).
  • [MeSH-minor] Humans. Neoplasm Staging. Pancreatic Cyst / diagnosis. Pancreatic Cyst / therapy. Prognosis

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  • (PMID = 19434873.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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5. Pandey M: Risk factors for gallbladder cancer: a reappraisal. Eur J Cancer Prev; 2003 Feb;12(1):15-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients present with extremes of clinical symptoms, indicating benign biliary diseases on the one hand and incurable malignant disease on the other.
  • Various aetiopathological agents have been proposed but none has stood the test of time.
  • In this article, we have reviewed the aetiopathological agents proposed from time to time over the past two centuries, with special emphasis on the developments made in the last 25 years.
  • [MeSH-minor] Carcinogens / adverse effects. Cholelithiasis / complications. Continental Population Groups. Diet. Ethnic Groups. Humans. Incidence. Infection / complications. Life Style. Lipid Peroxidation. Metallothionein. Metals, Heavy / adverse effects. Neoplasm Staging. Risk Factors

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  • (PMID = 12548106.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Metals, Heavy; 9038-94-2 / Metallothionein
  • [Number-of-references] 220
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6. Nakazawa S: Recent advances in endoscopic ultrasonography. J Gastroenterol; 2000;35(4):257-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endoscopic ultrasonography is recognized as an important tool in the diagnosis and staging of esophageal, gastric, colorectal, pancreatic, and biliary tumors.
  • It also is a reliable method for the evaluation of submucosal tumors of the gastrointestinal tract, the differentiation between benign and malignant giant gastric folds, the evaluation of gastric ulcer healing, and the detection of common bile duct stones.
  • This new technique may also be used for the intrasphincteric injection of botulinum toxin in the treatment of achalasia, for the steroid injection treatment of refractory esophageal strictures, for celiac nerve block, for pseudocyst drainage, and for drug delivery into pancreatic tumors.
  • [MeSH-minor] Biopsy, Needle. Digestive System / pathology. Humans. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 10777153.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] JAPAN
  • [Number-of-references] 51
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