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1. Tse GM, Niu Y, Shi HJ: Phyllodes tumor of the breast: an update. Breast Cancer; 2010;17(1):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the breast: an update.
  • Phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm.
  • Traditionally, phyllodes tumors are graded by the use of a set of histologic data into benign, borderline, and malignant.
  • In most series, all phyllodes tumors may recur, but only the borderline and malignant phyllodes tumors metastasize.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Female. Humans. Neoplasm Staging. Prognosis


2. Zhang K, Peng Y, Li D, Lin J, Luo Y, Wang T, Jiang Y: [The recognition of breast tumor based on ultrasonic image contour features]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2006 Dec;23(6):1237-40
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  • [Title] [The recognition of breast tumor based on ultrasonic image contour features].
  • The purpose of this article is to evaluate the role of quantitative margin features in the computer-aided diagnosis of malignant and benign solid breast masses using sonographic imaging.
  • Then back-propagation (BP) neural network with contour features was used to classify tumors into benign and malignant.
  • The methods applied in this paper are helpful to raise the correctance of breast cancer diagnosis.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Image Processing, Computer-Assisted / methods. Neural Networks (Computer)

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  • (PMID = 17228716.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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3. Uzan C, Andre F, Scott V, Laurent I, Azria E, Suciu V, Balleyguier C, Lacroix L, Delaloge S, Vielh P: Fine-needle aspiration for nucleic acid-ased molecular analyses in breast cancer. Cancer; 2009 Feb 25;117(1):32-9
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  • [Title] Fine-needle aspiration for nucleic acid-ased molecular analyses in breast cancer.
  • METHODS: Ultrasound- or palpation-guided FNAC was performed in 124 consecutive patients who had nodular breast lesions.
  • For malignant lesions, the authors attempted to correlate estrogen receptor 1 (ESR1) and HER-2 (c-erb-B2) mRNA expression measured by real-time quantitative polymerase chain reaction with estrogen receptor and HER-2 detection obtained by immunohistochemistry (IHC) and/or fluorescent in situ hybridization (FISH) on the surgical specimen.
  • RESULTS: The amount of mRNA obtained was >1 microg in 89.5% of 124 samples (43 benign lesions and 81 adenocarcinomas).
  • The most significant predictors of quality and quantity of mRNA were the cytopathologist who sampled the tumors and a diagnosis of cancer versus benign lesion.
  • CONCLUSIONS: In 70% of cases, FNAC of breast lesions in well trained hands allowed the extraction of mRNA suitable for gene expression analysis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biopsy, Fine-Needle. Breast Neoplasms / diagnosis. RNA, Messenger / isolation & purification

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19347827.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, ErbB-2
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4. Tse GM, Tan PH, Pang AL, Tang AP, Cheung HS: Calcification in breast lesions: pathologists' perspective. J Clin Pathol; 2008 Feb;61(2):145-51
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  • [Title] Calcification in breast lesions: pathologists' perspective.
  • Evaluation of calcification in breast lesions is a major assessment criterion for breast mammography.
  • Radiologically, calcifications can be divided into: benign; intermediate concern; and higher probability of malignancy according to the morphology.
  • Precursor malignant lesions give rise to benign to indeterminate type calcifications, and may occasionally be associated with malignant type calcifications.
  • For malignant lesions, ductal carcinoma in situ and invasive duct carcinoma may be associated with large irregular, rod or V shaped, pleomorphic or branching type calcifications that follow the distribution of the duct.
  • [MeSH-major] Breast Neoplasms / radiography. Calcinosis / radiography

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  • (PMID = 17704264.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 47
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5. Iqbal J, He G, Biesecker LG, Rosen P, Duray PH, Schwartzentruber D, Beg M, Kahn E: Morphological characterization of the breast in Proteus syndrome complicated by ductal carcinoma in situ. Ann Clin Lab Sci; 2006;36(4):469-74
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  • [Title] Morphological characterization of the breast in Proteus syndrome complicated by ductal carcinoma in situ.
  • It is associated with benign and occasionally malignant tumors.
  • This case highlights the difficulty of recognizing small foci of carcinoma in an asymmetrical overgrowth of the breast in a young woman with PS.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Proteus Syndrome / pathology

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  • (PMID = 17127737.001).
  • [ISSN] 0091-7370
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. McHugh JB, Visscher DW, Barnes EL: Update on selected salivary gland neoplasms. Arch Pathol Lab Med; 2009 Nov;133(11):1763-74
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  • [Title] Update on selected salivary gland neoplasms.
  • Salivary duct carcinoma is an aggressive malignancy characterized by histologic resemblance to breast carcinoma, high-grade cytologic features, and expression of androgen receptor.
  • Benign and malignant myoepithelial neoplasms have a broad morphologic spectrum, and immunohistochemistry is important in reaching the correct diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Carcinoma in Situ / diagnosis. Carcinosarcoma / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 19886710.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Huang YL, Jiang YR, Chen DR, Moon WK: Level set contouring for breast tumor in sonography. J Digit Imaging; 2007 Sep;20(3):238-47
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  • [Title] Level set contouring for breast tumor in sonography.
  • The echogenicity, echotexture, shape, and contour of a lesion are revealed to be effective sonographic features for physicians to identify a tumor as either benign or malignant.
  • Automatic contouring for breast tumors in sonography may assist physicians without relevant experience, in making correct diagnoses.
  • This study develops an efficient method for automatically detecting contours of breast tumors in sonography.
  • First, a sophisticated preprocessing filter reduces the noise, but preserves the shape and contrast of the breast tumor.
  • Finally, the deformation-based level set segmentation automatically extracts the precise contours of breast tumors from ultrasound (US) images.
  • The proposed contouring method evaluates US images from 118 patients with breast tumors.
  • The proposed method provides robust and fast automatic contouring for breast US images.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Image Processing, Computer-Assisted. Ultrasonography, Mammary

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  • (PMID = 17252171.001).
  • [ISSN] 0897-1889
  • [Journal-full-title] Journal of digital imaging
  • [ISO-abbreviation] J Digit Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3043893
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8. Barceló J, Vilanova JC, Albanell J, Ferrer J, Castañer F, Viejo N, Argelaguet M: [Breast MRI: the usefulness of diffusion-weighted sequences for differentiating between benign and malignant lesions]. Radiologia; 2009 Sep-Oct;51(5):469-76
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  • [Title] [Breast MRI: the usefulness of diffusion-weighted sequences for differentiating between benign and malignant lesions].
  • [Transliterated title] Resonancia magnética de mama: utilidad de la difusión para diferenciar entre lesiones benignas y malignas.
  • OBJECTIVE: To evaluate the usefulness of diffusion-weighted MRI sequences and of the apparent diffusion coefficient (ADC) to differentiate between benign and malignant breast lesions.
  • MATERIAL AND METHODS: We prospectively studied 88 patients (aged 31 to 79 years) with 94 lesions (80 malignant and 14 benign) who were referred for preoperative local staging.
  • RESULTS: The mean value of the ADC for malignant lesions (1.12+/-0.25x10(-3)mm(2)/s) was significantly lower (p<0.001) than for benign lesions (1.61+/-0.52x10(-3)mm(2)/s).
  • CONCLUSION: Diffusion-weighted sequences provide additional information in breast MRI that is useful for differentiating between benign and malignant lesions, thus improving the specificity of the technique.
  • [MeSH-major] Breast Diseases / diagnosis. Breast Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging

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  • (PMID = 19647840.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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9. Abbey CK, Zemp RJ, Liu J, Lindfors KK, Insana MF: Observer efficiency in discrimination tasks simulating malignant and benign breast lesions imaged with ultrasound. IEEE Trans Med Imaging; 2006 Feb;25(2):198-209
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  • [Title] Observer efficiency in discrimination tasks simulating malignant and benign breast lesions imaged with ultrasound.
  • We investigate and extend the ideal observer methodology developed by Smith and Wagner to detection and discrimination tasks related to breast sonography.
  • We have compared human performance for Wiener-filtered and conventional B-mode envelope images using psychophysical studies for 5 tasks related to breast cancer classification.

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  • (PMID = 16468454.001).
  • [ISSN] 0278-0062
  • [Journal-full-title] IEEE transactions on medical imaging
  • [ISO-abbreviation] IEEE Trans Med Imaging
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01-CA082497; United States / NCI NIH HHS / CA / R01 CA118294; United States / NCI NIH HHS / CA / R01 CA082497; United States / NCI NIH HHS / CA / CA118294-01A2; United States / NCI NIH HHS / CA / R21 CA102733; United States / NCI NIH HHS / CA / R01 CA118294-01A2
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS122105; NLM/ PMC2715171
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10. Kooistra BW, Wauters C, van de Ven S, Strobbe L: The diagnostic value of nipple discharge cytology in 618 consecutive patients. Eur J Surg Oncol; 2009 Jun;35(6):573-7
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  • On ND cytology, benign diagnoses were considered negative, whereas suspicious and malignant diagnoses were considered positive for malignancy.
  • Only 1 malignant lesion was designated positive solely by ND cytology (unique sensitivity (95% CI), 2.8% (0.0-8.4%)) and 3 lesions were correctly classified as negative by ND cytology (unique specificity (95% CI), 1.6%, 0.0-3.7%)).
  • Therefore, its routine use for detection of ND-related breast pathology should be reconsidered carefully.
  • [MeSH-major] Breast Neoplasms / pathology. Exudates and Transudates / cytology. Nipples / secretion
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / pathology. Female. Humans. Male. Mammography. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 18986790.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Baltzer PA, Renz DM, Kullnig PE, Gajda M, Camara O, Kaiser WA: Application of computer-aided diagnosis (CAD) in MR-mammography (MRM): do we really need whole lesion time curve distribution analysis? Acad Radiol; 2009 Apr;16(4):435-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Fifty-one patients with 46 malignant and 44 benign lesions were enrolled.
  • [MeSH-major] Algorithms. Artificial Intelligence. Breast Neoplasms / diagnosis. Image Interpretation, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Pattern Recognition, Automated / methods


12. Korzeniewski N, Wheeler S, Chatterjee P, Duensing A, Duensing S: A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention. Mol Cancer; 2010 Jun 17;9:153
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  • BACKGROUND: Centrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer.
  • We therefore test here whether small molecule CDK inhibitors derived from the bis-indole indirubin can be used to suppress centrosome aberrations as a novel approach to chemoprevention of malignant progression.
  • RESULTS: As expected, we found that the CDK inhibitor indirubin-3'-oxime (IO) suppresses centrosome amplification in breast cancer cells.
  • Remarkably, a considerable proportion (72.7%) of benign mammary tissue samples scored also positive for nuclear AhR overexpression.
  • CONCLUSIONS: Our results indicate that continued expression of endogenous AhR promotes centrosome amplification in breast cancer cells in a pathway that involves cyclin E.
  • AhR agonists such as indirubins inhibit centrosome amplification even when stimulated by ectopic expression of the AhR suggesting that these compounds are potentially useful for the chemoprevention of centrosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed.
  • Future studies are warranted to determine whether individuals in which nuclear AhR overexpression is detected in benign mammary tissue are at a higher risk for developing pre-cancerous or cancerous breast lesions.

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  • (PMID = 20565777.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA112598
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 0 / Receptors, Aryl Hydrocarbon
  • [Other-IDs] NLM/ PMC2898706
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13. Reid-Nicholson MD, Tong G, Cangiarella JF, Moreira AL: Cytomorphologic features of papillary lesions of the male breast: a study of 11 cases. Cancer; 2006 Aug 25;108(4):222-30
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  • [Title] Cytomorphologic features of papillary lesions of the male breast: a study of 11 cases.
  • BACKGROUND: Breast masses occur in men far less commonly than women and are infrequently subjected to fine-needle aspiration (FNA) biopsy.
  • Papillary lesions of the male breast are rare and are comprised of a spectrum of lesions ranging from papillary hyperplasia in gynecomastia to invasive papillary carcinoma.
  • The following study describes the cytomorphology of papillary breast lesions in 11 men.
  • The patients ranged in age from 23 to 78 years old and each presented with an unilateral subareolar or periareolar breast mass that varied in size from 0.5 to 3 cm.
  • METHODS: Archival material (8-year period) from FNA biopsies of papillary lesions of the male breast was reviewed.
  • Nipple discharge was seen only in the 2 benign lesions.
  • CONCLUSIONS: The only cytologic criteria that differentiated benign from malignant papillary lesions were marked cellularity and the presence of abundant 3-dimensional clusters.
  • To the best of the authors' knowledge, the current series is the largest in the English literature to date that examines the cytomorphologic features of papillary breast lesions in men.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Papillary / pathology

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16721805.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Trott KR, Kamprad F: Estimation of cancer risks from radiotherapy of benign diseases. Strahlenther Onkol; 2006 Aug;182(8):431-6
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  • [Title] Estimation of cancer risks from radiotherapy of benign diseases.
  • BACKGROUND: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases.
  • METHODS: The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Bone Marrow / radiation effects. Brain Neoplasms / epidemiology. Brain Neoplasms / etiology. Breast Neoplasms / etiology. Carcinoma, Basal Cell / etiology. Child. Cohort Studies. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Incidence. Lung Neoplasms / epidemiology. Lung Neoplasms / etiology. Male. Mastitis / radiotherapy. Middle Aged. Neoplasms, Radiation-Induced / etiology. Peptic Ulcer / radiotherapy. Radiodermatitis / etiology. Radiotherapy Dosage. Retinal Neoplasms / radiotherapy. Retinoblastoma / radiotherapy. Risk. Risk Factors. Sarcoma / etiology. Sarcoma / radiotherapy. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Spondylitis, Ankylosing / radiotherapy. Thyroid Neoplasms / etiology. Time Factors. Tinea Capitis / radiotherapy

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  • (PMID = 16896588.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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15. Mhawech-Fauceglia P, Saxena R, Zhang S, Terracciano L, Sauter G, Chadhuri A, Herrmann FR, Penetrante R: Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis. J Clin Pathol; 2007 Jun;60(6):709-14
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  • [Title] Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis.
  • AIMS AND METHODS: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections.
  • In addition, Pax-5 was seen in 24/34 (70.6%) Merkel cell carcinomas, 42/53 (79.2%) small cell carcinomas, 1/164 (0.6%) breast carcinomas, 2/204 (1%) endometrial adenocarcinomas and 1/452 (0.2%) urothelial carcinoma of the bladder.
  • [MeSH-major] B-Cell-Specific Activator Protein / metabolism. Biomarkers, Tumor / metabolism. Neoplasms / metabolism
  • [MeSH-minor] Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / metabolism. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Hodgkin Disease / diagnosis. Hodgkin Disease / metabolism. Humans. Immunoenzyme Techniques. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / metabolism. Neoplasm Proteins / metabolism. Protein Array Analysis / methods

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  • (PMID = 16837628.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / PAX5 protein, human
  • [Other-IDs] NLM/ PMC1955074
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16. Wauters CA, Kooistra B, Strobbe LJ: The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation. J Clin Pathol; 2009 Oct;62(10):931-4
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  • [Title] The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation.
  • AIM: To compare breast fine needle aspiration (FNA) specimens prepared by conventional smearing (CS) versus monolayer preparation (MP), with respect to the conclusiveness of the cytopathological diagnosis.
  • FNA diagnoses were categorised into inadequate (C1), benign (C2), atypical (C3), suspicious for malignancy (C4) and malignant (C5).
  • A conclusive FNA diagnosis was defined as C2 in lesions benign on follow-up and C5 in lesions malignant on histology.
  • This effect remained significant when corrected for the difference in ultrasound guidance (adjusted odds ratio 1.7, 95% confidence interval 1.3 to 2.2, p<0.001), and was larger for malignant lesions than for benign lesions (51.7% versus 79.9%, p<0.001).
  • CONCLUSION: Patients presenting with breast lesions can more often be offered a same-day, conclusive cytopathological diagnosis when FNA are prepared by a manual MP processing technique.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology

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  • (PMID = 19783723.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Barr RG, Maldonado RL, Georgian-Smith D: Comparison of conventional, compounding, computer enhancement, and compounding with computer enhancement in ultrasound imaging of the breast. Ultrasound Q; 2009 Sep;25(3):129-34
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  • [Title] Comparison of conventional, compounding, computer enhancement, and compounding with computer enhancement in ultrasound imaging of the breast.
  • OBJECTIVE: Real-time spatial compounding and computer enhancement (CE) in ultrasound have become commercially available for better visualization of breast masses.
  • This study evaluated image quality and diagnostic information using these techniques as compared with conventional ultrasound in breast imaging.
  • MATERIALS AND METHODS: One hundred consecutive lesions in 81 patients with clinically detectable breast lesions were imaged using conventional, compounding, CE, and compounding with CE.
  • RESULTS: The lesions included benign (81) and malignant (19) lesions.
  • CONCLUSION: Compounding with CE significantly improves the image quality over conventional breast ultrasound.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Image Enhancement / methods. Ultrasonography, Mammary / methods

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  • (PMID = 19730052.001).
  • [ISSN] 1536-0253
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Renz M, Langowski J: Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS. Chromosome Res; 2008;16(3):427-37
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  • As an example we report our studies on the intracellular mobility of the actin-binding protein CapG in live breast cancer cells.
  • It appears to be overexpressed especially in metastasizing breast cancer.
  • Furthermore, the CapG protein is known to be involved in the motility control of non-muscle benign cells.
  • Its increased expression triggers an increase in cell motility of benign cells.
  • Since the nuclear CapG fraction seems to be pivotal to the increase in cell motility, we focused our studies on the CapG mobility in cell nuclei of live breast cancer cells.
  • This information about the mobility and compartmentalization of CapG might help to provide insight into its function within the cell nucleus and give clues about its altered cellular function in malignant dedifferentiation.
  • [MeSH-minor] Biological Transport, Active. Breast Neoplasms / metabolism. Breast Neoplasms / physiopathology. Breast Neoplasms / ultrastructure. Cell Line, Tumor. Cell Movement. Female. Green Fluorescent Proteins / genetics. Green Fluorescent Proteins / metabolism. Humans. Kinetics. Neoplasm Invasiveness. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism

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  • (PMID = 18461482.001).
  • [ISSN] 0967-3849
  • [Journal-full-title] Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
  • [ISO-abbreviation] Chromosome Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Nuclear Proteins; 0 / Recombinant Fusion Proteins; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; 148412-71-9 / CAPG protein, human
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19. Dahl E, Kristiansen G, Gottlob K, Klaman I, Ebner E, Hinzmann B, Hermann K, Pilarsky C, Dürst M, Klinkhammer-Schalke M, Blaszyk H, Knuechel R, Hartmann A, Rosenthal A, Wild PJ: Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res; 2006 Jul 1;12(13):3950-60
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  • [Title] Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer.
  • PURPOSE: The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer.
  • EXPERIMENTAL DESIGN: Twenty-four matched pairs of invasive ductal breast cancer and corresponding benign breast tissue were investigated by a combination of laser microdissection and gene expression profiling.
  • Differential expression of candidate genes was validated by dot blot analysis of cDNA in 50 pairs of matching benign and malignant breast tissue.
  • Cellular expression of candidate genes was further validated by RNA in situ hybridization, quantitative reverse transcription-PCR, and immunohistochemistry using tissue microarray analysis of 272 nonselected breast cancers.
  • CONCLUSIONS: Gene expression profiling of laser-microdissected breast cancer tissue revealed novel genes that may represent potential molecular targets for breast cancer therapy and prediction of outcome.
  • [MeSH-major] Biomarkers, Tumor / genetics. Breast Neoplasms. Carcinoma, Ductal, Breast. Gene Expression Profiling. Lasers. Microdissection / methods. alpha Karyopherins / genetics
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Multivariate Analysis. Neoplasm Staging. Phosphatidate Phosphatase / genetics. Prognosis. RNA / genetics. Regression Analysis. Reverse Transcriptase Polymerase Chain Reaction / methods. Sulfotransferases / genetics. Survival Rate. Tissue Array Analysis / methods. Up-Regulation / genetics

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  • (PMID = 16818692.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha Karyopherins; 0 / karyopherin alpha 2; 63231-63-0 / RNA; EC 2.8.2.- / SULF1 protein, human; EC 2.8.2.- / Sulfotransferases; EC 3.1.3.- / lipid phosphate phosphatase; EC 3.1.3.4 / Phosphatidate Phosphatase
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20. Caldefie-Chézet F, Damez M, de Latour M, Konska G, Mishellani F, Fusillier C, Guerry M, Penault-Llorca F, Guillot J, Vasson MP: Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun; 2005 Sep 2;334(3):737-41
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  • [Title] Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma.
  • It was also shown to stimulate the proliferation of breast cancer cell lines.
  • In this study, we conducted an immunohistochemical analysis of leptin expression in normal tissue and benign and malignant ductal breast cell, representing the different states of the invasion process.
  • We determined for the first time that leptin is expressed both by ductal breast tumors and by benign lesions as atypical hyperplasia.
  • This suggests that leptin may be taken up or synthesized by all modified ductal breast cells, and may prove a proliferative factor.
  • Moreover, leptin is unexpressed by normal tissue in the healthy breast but is exhibited by the normal tissue in near vicinity of the malignant ductal breast lesions.
  • We also postulated that leptin may be a prognostic or diagnostic factor for ductal breast cancer.
  • [MeSH-major] Breast Neoplasms / physiopathology. Carcinoma, Ductal, Breast / physiopathology. Leptin / physiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast / metabolism. Carcinoma in Situ / physiopathology. Female. Humans. Middle Aged

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  • (PMID = 16009333.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin
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21. Sampatanukul P, Boonjunwetwat D, Thanakit V, Pak-Art P: Integrated criteria of fine-needle aspiration cytology and radiological imaging for verification of breast cancer in nonpalpable lesions. J Med Assoc Thai; 2006 Feb;89(2):236-41
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  • [Title] Integrated criteria of fine-needle aspiration cytology and radiological imaging for verification of breast cancer in nonpalpable lesions.
  • OBJECTIVES: To evaluate the accuracy of using radiologic, cytologic and integrated radiologic and cytologic criteria in diagnosis of nonpalpable breast lesions.
  • RESULTS: There were 162 lesions from 150 patients, consisting of 29 malignant neoplasms (17.9%) and 133 benign lesions (82.1%).
  • While the 23 large/ill-defined lesions (> 1.5 x 1.5 cm2 in size), one hiding malignant lesion adjacent to a prominent intraduct papilloma was missed.
  • CONCLUSION: The integrated criteria provide the most accuracy rate and sensitivity rate for detection of malignancy in nonpalpable breast lesions.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / radiography. Carcinoma / pathology. Carcinoma / radiography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Mammography / methods. Middle Aged. Neoplasm Staging. Prospective Studies. Risk Assessment. Sensitivity and Specificity. Survival Analysis

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  • (PMID = 16579012.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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22. Pérez Monter SE, Arteaga Gómez AC, Gorbea Chávez V, Aranda Flores CE: [Surgical approach of breast nodules during pregnancy]. Ginecol Obstet Mex; 2009 Apr;77(4):189-96
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  • [Title] [Surgical approach of breast nodules during pregnancy].
  • [Transliterated title] Abordaje quirúrgico de nódulos mamarios durante el embarazo.
  • BACKGROUND: Only in Mexico, about four thousand women die from breast cancer of which 11 thousand are diagnosed.
  • Is undoubtedly the most malignant disease throughout the world are diagnosed each year as over one million every year and the figure grows.
  • OBJECTIVE: To analyze the results of six years of experience in the therapeutic treatment of breast nodules during pregnancy which describes the treatment, establishing the diagnosis of breast biopsies, reported complications associated with obtaining the same.
  • MATERIAL AND METHODS: We reviewed a database of search terms: pregnancy and breast nodule from January 1 2001 to December 31, 2006.
  • In 13 of the patients were breast fibroadenoma, and only one was diagnosed with infiltrating ductal carcinoma le.
  • CONCLUSION: Our study was the Breast fibroadenoma lesion was found in more common.
  • In our experience with the management of breast nodules in pregnancy, we can say that most of the lesions are benign, and usually are commonly encountered pathologies in nonpregnant women.
  • In the case of diagnosing breast cancer, we must make the decision about the best treatment to offer the best possible forecasts.
  • [MeSH-major] Breast Diseases / surgery. Breast Neoplasms / surgery. Pregnancy Complications / surgery. Pregnancy Complications, Neoplastic / surgery


23. Takei H, Ruiz B, Dancer J, Hicks J: Fine needle aspiration of poorly defined indurated and well-defined breast lesions: a cytopathologic comparative study. Acta Cytol; 2007 Sep-Oct;51(5):692-8
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  • [Title] Fine needle aspiration of poorly defined indurated and well-defined breast lesions: a cytopathologic comparative study.
  • OBJECTIVE: To compare the cytologic findings and diagnoses of breast fine needle aspiration (FNA) samples of well-defined lesions (WDL) with those of poorly defined indurated lesions.
  • STUDY DESIGN: We examined 371 consecutive breast FNA specimens obtained without diagnostic image guidance.
  • However, a substantial number of atypical, suspicious for malignancy and malignant cases (12.1%, 5.2%, and 13.8%, respectively) were identified with PDILs.
  • In addition, benign diagnoses were more frequently rendered with aspirates of WDLs, compared with PDILs (47.9% vs. 31.0%).
  • CONCLUSION: Given the relatively high frequency of malignant, suspicious and atypical lesions detected with PDILs, FNA is a suitable first diagnostic approach for PDILs, especially considering the relatively low cost and simplicity of FNA procedures without diagnostic imaging guidance.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology

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  • (PMID = 17910338.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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24. Perlet C, Heywang-Kobrunner SH, Heinig A, Sittek H, Casselman J, Anderson I, Taourel P: Magnetic resonance-guided, vacuum-assisted breast biopsy: results from a European multicenter study of 538 lesions. Cancer; 2006 Mar 1;106(5):982-90
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  • [Title] Magnetic resonance-guided, vacuum-assisted breast biopsy: results from a European multicenter study of 538 lesions.
  • BACKGROUND: The objective of this study was to determine the accuracy, reproducibility, and clinical value of magnetic resonance (MR)-guided, vacuum-assisted breast biopsy (MR-VAB) in a prospective, multicenter study.
  • Verification of malignant or borderline lesions included reexcision of the biopsy cavity.
  • Benign biopsy results were verified by retrospective correlation of histology with preinterventional and postinterventional MRI studies.
  • Histology yielded 138 (27%) malignancies, 17 (3%) atypical ductal hyperplasias, and 362 (70%) benign entities.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Magnetic Resonance Imaging

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  • (PMID = 16456807.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] United States
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25. Dietzel M, Baltzer PA, Vag T, Herzog A, Gajda M, Camara O, Kaiser WA: The necrosis sign in magnetic resonance-mammography: diagnostic accuracy in 1,084 histologically verified breast lesions. Breast J; 2010 Nov-Dec;16(6):603-8
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  • [Title] The necrosis sign in magnetic resonance-mammography: diagnostic accuracy in 1,084 histologically verified breast lesions.
  • Necrosis sign (NS) is a new descriptor for differential diagnosis of breast lesions in magnetic resonance (MR)-mammography (MRM).
  • This study was designed: (a) to analyze diagnostic accuracy of NS in 1,084 histologically verified breast lesions, (b) to assess performance of NS in subgroups.
  • Patients with history of breast biopsy (surgically, minimal-invasive), radiation- or chemotherapy ≤ 1 year before MRM were excluded.
  • One thousand and eighty-four lesions were available for statistical analysis (648: malignant, 436: benign).
  • Malignant lesions > 20 mm presented significantly more often NS (p < 0.001) than neoplasias ≤ 20 mm.
  • There was no difference regarding prevalence of NS in small versus advanced benign lesions (n.s.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Mammography


26. Kumar KK, Chowdary MV, Mathew S, Rao L, Krishna CM, Kurien J: Protein profile study of breast-tissue homogenates by HPLC-LIF. J Biophotonics; 2009 May;2(5):313-21
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  • [Title] Protein profile study of breast-tissue homogenates by HPLC-LIF.
  • In this study, we have explored the feasibility of classifying breast tissues by multivariate analysis of chromatographic data.
  • We have analyzed 13 normal, 17 malignant, 5 benign and 4 post-treatment breast-tissue homogenates.
  • [MeSH-major] Breast / cytology. Breast / metabolism. Lasers. Proteomics / methods
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Breast Neoplasms / therapy. Chromatography, High Pressure Liquid. Fluorescence. Humans. Multivariate Analysis. Principal Component Analysis. Survival Analysis

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  • (PMID = 19434612.001).
  • [ISSN] 1864-0648
  • [Journal-full-title] Journal of biophotonics
  • [ISO-abbreviation] J Biophotonics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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27. Li X, Huang W, Yankeelov TE, Tudorica A, Rooney WD, Springer CS Jr: Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast disease. Magn Reson Med; 2005 Mar;53(3):724-9
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  • [Title] Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast disease.
  • Here, the standard and shutter-speed models are applied to B-T data obtained from routine human breast examinations.
  • The size of the mismatch is considerably greater for the IDC lesions than for the FA lesions, causing the shutter-speed model to exhibit improved discrimination of malignant IDC tumors from the benign FA lesions compared with the standard model.
  • Furthermore, the shutter-speed model clearly reveals focal "hot spots" of elevated CR perfusion/permeation present in only the malignant tumors.
  • [MeSH-major] Breast Diseases / metabolism. Carcinoma, Ductal, Breast / metabolism. Contrast Media / pharmacokinetics. Fibroadenoma / metabolism. Gadolinium DTPA / pharmacokinetics
  • [MeSH-minor] Breast Neoplasms / metabolism. Female. Humans. Image Processing, Computer-Assisted

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15723402.001).
  • [ISSN] 0740-3194
  • [Journal-full-title] Magnetic resonance in medicine
  • [ISO-abbreviation] Magn Reson Med
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB 00422; United States / NINDS NIH HHS / NS / R01 NS 40801
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 84F6U3J2R6 / gadodiamide; K2I13DR72L / Gadolinium DTPA
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28. Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, Giannopoulos A, Mantzoros CS: Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev; 2007 Feb;16(2):308-13
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  • PURPOSE: Adiponectin, an adipocyte-secreted hormone with insulin-sensitizing effects, has been inversely associated with several hormonally dependent malignancies, including breast, endometrial, and colorectal cancer.
  • EXPERIMENTAL DESIGN: We collected plasma samples and covariate data in the context of a case-control study of 300 Greek men, including 75 prostate cancer cases, 75 patients with benign prostatic hyperplasia (BPH), and 150 healthy controls.
  • Malignant prostate tissue samples have reduced expression of adiponectin receptors as compared with benign prostate tissue.
  • [MeSH-major] Adiponectin / blood. Biomarkers, Tumor / metabolism. Prostatic Hyperplasia / metabolism. Prostatic Neoplasms / metabolism. Receptors, Cell Surface / metabolism


29. Liang Z, Du X, Liu J, Yao X, Yang Y, Li K: Comparison of diagnostic accuracy of breast masses using digitized images versus screen-film mammography. Acta Radiol; 2008 Jul;49(6):618-22
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  • [Title] Comparison of diagnostic accuracy of breast masses using digitized images versus screen-film mammography.
  • PURPOSE: To compare the diagnostic accuracy in the interpretation of breast masses using original screen-film mammograms versus digitized images.
  • MATERIAL AND METHODS: A total of 72 female patients between 55 and 81 years of age suspected of having breast cancer were selected by two non-observing radiologists.
  • Of these, 31 cases were benign lesions and 41 cases were cancer.
  • A four-point malignancy scale was used, with 1 defined as definitely not malignant, 2 as probably not malignant, 3 as probably malignant, and 4 as definitely malignant.
  • The detection specificity of extremely dense breasts was lower than that for other breast compositions for both digitized images and screen-film mammograms.
  • No statistical significance in sensitivity and specificity was observed between digitized images and mammograms for each breast composition.
  • CONCLUSION: Digitized images with a spatial resolution of 175 microm can be used instead of screen-film mammograms in the diagnosis of breast cancer.
  • [MeSH-major] Breast Neoplasms / diagnosis. Image Interpretation, Computer-Assisted / methods. Mammography / methods. Radiographic Image Enhancement / methods

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  • (PMID = 18568552.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
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30. Yang DM, Kim HC, Lim JW, Jin W, Ryu CW, Kim GY, Cho H: Sonographic findings of groin masses. J Ultrasound Med; 2007 May;26(5):605-14
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  • The most common benign tumor of the inguinal region was a lipoma.
  • Other benign tumors of the groin included leiomyomas, dermoid cysts, epidermoid cysts, and lymphangiomas.
  • The most common primary malignant tumors in the inguinal region were sarcomas such as rhabdomyosarcoma and liposarcoma.
  • Secondary malignant tumors of the inguinal regions were metastatic lymphomas and metastatic carcinomas of the lung, breast, ovary, and gastrointestinal tract.
  • [MeSH-major] Abdominal Neoplasms / ultrasonography. Groin / ultrasonography. Hernia, Inguinal / ultrasonography. Sarcoma / ultrasonography. Ultrasonography / methods

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  • (PMID = 17460003.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Su Y, Wang H, Wang Y, Guo Y, Cheng H, Zhang Y, Tian J: Speckle reduction approach for breast ultrasound image and its application to breast cancer diagnosis. Eur J Radiol; 2010 Jul;75(1):e136-41
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  • [Title] Speckle reduction approach for breast ultrasound image and its application to breast cancer diagnosis.
  • OBJECTIVES: To retrospectively evaluate the effects of a speckle reduction algorithm on radiologists' diagnosis of malignant and benign breast lesions on ultrasound (US) images.
  • METHODS: Using a database of 603 breast (US) images of 211 cases (109 benign lesions and 102 malignant ones), the original and speckle-reduced images were assessed by five radiologists and final assessment categories were assigned to indicate the probability of malignancy according to BI-RADS-US.
  • RESULTS: The sensitivity and specificity of breast lesions on Ultrasound images improved from 88.7% to 94.3%, from 68.6% to 75.2%, respectively, and the area (Az) under ROC curve of diagnosis also increased from 0.843 to 0.939, Z=4.969, there were significant differences in the Az between the original breast lesions and speckle-reduced ones on Ultrasound images (P<0.001).
  • The diagnostic accuracy of breast lesions had been highly improved from 78.67% to 92.73% after employing this algorithm.
  • CONCLUSIONS: The results demonstrate the promising performance of the proposed speckle reduction algorithm in distinguishing malignant from benign breast lesions which will be useful for breast cancer diagnosis.
  • [MeSH-major] Algorithms. Artifacts. Breast Neoplasms / ultrasonography. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Ultrasonography, Mammary / methods

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19913380.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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32. Abulkhair OA, Al Tahan FM, Young SE, Musaad SM, Jazieh AR: The first national public breast cancer screening program in Saudi Arabia. Ann Saudi Med; 2010 Sep-Oct;30(5):350-7
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  • [Title] The first national public breast cancer screening program in Saudi Arabia.
  • BACKGROUND AND OBJECTIVES: Despite its relatively low incidence in Saudi Arabia, breast cancer has been the most common cancer among Saudi females for the past 12 consecutive years.
  • The objective of this study was to report the results of the first national public breast cancer screening program in Saudi Arabia.
  • METHODS: Women 40 years of age or older underwent breast cancer screening.
  • Mammograms were scored using the Breast Imaging-Reporting and Data System (BI-RADS).
  • However, among 26 women with R4/R5 scores, 50% had malignant disease and 35% had benign lesions.
  • CONCLUSIONS: Public acceptance of the breast cancer screening program was encouraging.
  • [MeSH-major] Breast Neoplasms / radiography. Mass Screening / methods

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  • (PMID = 20697170.001).
  • [ISSN] 0975-4466
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC2941246
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33. Pruthi RS, Lentz AC, Sand M, Kouba E, Wallen EM: Impact of marital status in patients undergoing radical cystectomy for bladder cancer. World J Urol; 2009 Aug;27(4):573-6
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  • PURPOSE: Married (vs. unmarried) individuals have improved health status and longer life expectancies in a variety of benign and malignant disease states, including prostate, breast, head/neck, and lung cancers.
  • [MeSH-major] Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / surgery. Cystectomy. Marital Status. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / surgery

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  • (PMID = 19219612.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AYI8EX34EU / Creatinine
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34. Schlossbauer T, Leinsinger G, Wismuller A, Lange O, Scherr M, Meyer-Baese A, Reiser M: Classification of small contrast enhancing breast lesions in dynamic magnetic resonance imaging using a combination of morphological criteria and dynamic analysis based on unsupervised vector-quantization. Invest Radiol; 2008 Jan;43(1):56-64
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  • [Title] Classification of small contrast enhancing breast lesions in dynamic magnetic resonance imaging using a combination of morphological criteria and dynamic analysis based on unsupervised vector-quantization.
  • PURPOSE: To evaluate the diagnostic value of breast magnetic resonance imaging (MRI) in small focal lesions using dynamic analysis based on unsupervised vector quantization in combination with a score for morphologic criteria.
  • MATERIALS AND METHODS: We examined 85 mammographically indetermintate lesions (BIRADS 3-4; 47 malignant, mean lesion size 1.2 cm; 38 benign, mean lesion size 1.1 cm).
  • RESULTS: In the present collection of small lesions, morphologic criteria [area under the curve (AUC) = 0.610] were inferior to dynamic criteria in the detection of breast cancer.

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  • (PMID = 18097278.001).
  • [ISSN] 0020-9996
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA106799-03; United States / NCI NIH HHS / CA / K25 CA106799-03
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ NIHMS134736; NLM/ PMC2758815
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35. Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV: Hidradenoma papilliferum with a ductal carcinoma in situ component: case report and review of the literature. Am J Dermatopathol; 2008 Aug;30(4):392-4
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  • Hidradenoma papilliferum (HP) is a benign cutaneous adnexal neoplasm occurring mainly in the anogenital region of adult women and has features analogous to intraductal papilloma of the breast.
  • Malignant change in HP is extremely rare.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal / pathology. Sweat Gland Neoplasms / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18645314.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Vanhoutte A, Fellah L, Galant C, d'Hoore W, Berlière M, Leconte I: [Contribution of sonoelastography to the characterization of breast lesions]. JBR-BTR; 2008 Sep-Oct;91(5):187-94
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  • [Title] [Contribution of sonoelastography to the characterization of breast lesions].
  • We evaluate the performances of sonoelastography in the characterization of breast nodules with histologic correlation.
  • The scores 1-3 were considered as benign and 4-5 as malignant.
  • At histology, 16 nodules were malignant and 49 nodules were benign.
  • Elastosonography is a simple, rapid and complementary method to mode B sonography that can improve the specificity in the characterization of breast nodules and the management of BI-RADS 3 nodules, leading to a decrease of false-positive and short term follow-up rates.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma / diagnosis. Elasticity Imaging Techniques / methods. Ultrasonography, Mammary / methods

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  • (PMID = 19051937.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] fre
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Belgium
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37. Rovera F, Ferrari A, Carcano G, Dionigi G, Cinquepalmi L, Boni L, Diurni M, Dionigi R: Tubular adenoma of the breast in an 84-year-old woman: report of a case simulating breast cancer. Breast J; 2006 May-Jun;12(3):257-9
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  • [Title] Tubular adenoma of the breast in an 84-year-old woman: report of a case simulating breast cancer.
  • Tubular adenomas of the breast are rare and they mainly occur in young women.
  • They must be differentiated from other benign lesions and from malignant breast cancer.
  • This article describes a case of an 84-year-old woman suffering from tubular adenoma of the breast.
  • The authors underline the difficulty in preoperative differentiation between benign and malignant breast lesions.
  • [MeSH-major] Adenoma / diagnosis. Breast Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Breast / pathology. Breast Diseases / diagnosis. Diagnosis, Differential. Female. Humans. Mammography. Ultrasonography, Mammary

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  • (PMID = 16684324.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Sohns C, Angic BC, Sossalla S, Konietschke F, Obenauer S: CAD in full-field digital mammography-influence of reader experience and application of CAD on interpretation of time. Clin Imaging; 2010 Nov-Dec;34(6):418-24
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  • AIM: To assess time expenditure using the influence of computer-assisted detection (CAD) system in the interpretation of the dependence of early research and benign and malignant mammograms on readers' experience.
  • MATERIALS AND METHODS: CAD (Image Checker V2.3; R2 Technology, Los Altos, CA, USA) was prospectively applied on digital mammograms of 303 patients [early research (n=103), benign (n=102), and malignant group (n=98)].
  • In comparison, the P value for the malignant and benign groups shows significant interactions between the readers' experiences as well as CAD application.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / radiography. Mammography / utilization. Professional Competence / statistics & numerical data. Radiographic Image Interpretation, Computer-Assisted / methods. Workload / statistics & numerical data


39. Tsuchiya S, Akiyama F, Moriya T, Tsuda H, Umemura S, Katayama Y, Ishihara A, Inai Y, Itoh H, Kitamura T: A new reporting form for breast cytology. Breast Cancer; 2009;16(3):202-6
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  • [Title] A new reporting form for breast cytology.
  • The Cytology and Core Needle Biopsy Subcommittee, organized under the Rules Committee of the Japanese Breast Cancer Society, has prepared a new form for breast cytology reports.
  • The judgment on "specimen adequacy" is subdivided into four categories: "normal or benign," "indeterminate," "suspicious for malignancy," and "malignant."
  • (1) the percentage of "specimen inadequacy" should be 10% or less of all samples, (2) the percentage of "indeterminate" samples should be 10% or less of all "specimen adequacy" cases, and (3) 90% or more of "suspicious for malignancy" cases should be diagnosed as "malignant" in a subsequent histological examination.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Breast Neoplasms / pathology. Cytodiagnosis / methods. Forms and Records Control / standards

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  • (PMID = 19484337.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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40. Doucas H, Neal CP, O'Reilly K, Dennison AR, Berry DP: Frozen section diagnosis of pancreatic malignancy: a sensitive diagnostic technique. Pancreatology; 2006;6(3):210-3; discussion 214
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  • 19 (15.8%) patients had malignant disease outside the pancreas, making their tumours unsuitable for curative resection.
  • CONCLUSIONS: Frozen section diagnosis is very reliable in the assessment of pancreatic masses and accurately differentiates between benign and malignant disease.
  • [MeSH-major] Frozen Sections. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Carcinoma, Ductal, Breast / pathology. False Negative Reactions. Female. Humans. Intraoperative Period. Male. Middle Aged. Pancreas / pathology

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  • (PMID = 16534244.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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41. Caproni N, Marchisio F, Pecchi A, Canossi B, Battista R, D'Alimonte P, Torricelli P: Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI. Eur Radiol; 2010 Jun;20(6):1384-95
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  • [Title] Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI.
  • OBJECTIVE: To evaluate the reliability of contrast-enhanced ultrasound quantitative analysis (CE-US) in characterizing breast lesions, in comparison with MRI.
  • MATERIALS: Thirty-nine patients with breast lesions BI-RADS 3-5 at US or mammography underwent CE-US and MRI.
  • RESULTS: Pathology showed 43 nodules (11 benign; 32 malignant).
  • [MeSH-major] Algorithms. Breast Neoplasms / diagnosis. Image Interpretation, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Phospholipids. Sulfur Hexafluoride. Ultrasonography, Mammary / methods

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  • (PMID = 20033178.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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42. He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S: Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep; 2005 Oct;14(4):1013-9
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  • S-TK1 concentration and STK activity levels were determined in 9 human malignant diseases (breast, gastric, rectal, colorectal, lung, brain cancer, hepatoma, lymphoma, leukaemia) and in benign and non-cancerous diseases, representing 850 preoperative cases.
  • S-TK1 concentrations and STK activity levels in preoperative malignant patients were significantly higher than in healthy individuals, in patients with benign tumors and in those with non-cancerous diseases.
  • Significant correlations between concentration and activity level were only found in healthy individuals, in patients with benign tumors, and in some patients with malignancies, i.e. leukaemia, and breast and gastric cancers.
  • About 90-95 percent of the malignant patients showed S-TK1 concentrations above those of the healthy controls.
  • When sera from malignant patients were diluted with sera from healthy individuals, S-TK1 concentrations and STK activity levels decreased more than expected.
  • [MeSH-major] Biomarkers, Tumor. Neoplasms / blood. Neoplasms / diagnosis. Thymidine Kinase / blood
  • [MeSH-minor] Breast Neoplasms / pathology. Cell Line, Tumor. Cell Proliferation. Dose-Response Relationship, Drug. Female. Humans. Male. Neoplasm Staging. Radioimmunoassay / methods. Stomach Neoplasms / pathology

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  • (PMID = 16142366.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.21 / Thymidine Kinase; EC 2.7.1.21 / thymidine kinase 1
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43. Titus-Ernstoff L, Troisi R, Hatch EE, Hyer M, Wise LA, Palmer JR, Kaufman R, Adam E, Noller K, Herbst AL, Strohsnitter W, Cole BF, Hartge P, Hoover RN: Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation. Epidemiology; 2008 Mar;19(2):251-7
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  • [Title] Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation.
  • METHODS: We assessed cancer and benign pathology diagnoses occurring in the offspring of women whose prenatal exposure to DES (or lack of exposure) was verified by medical record.
  • Our data arose from 2 sources: the mothers' reports of cancers occurring in 8216 sons and daughters, and pathology-confirmed cancers and benign diagnoses self-reported by a subset of 793 daughters.
  • Based on pathology-confirmed diagnoses reported by the daughters, we saw no association between DES and risk of benign breast disease or reproductive tract conditions.

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  • (PMID = 18223485.001).
  • [ISSN] 1044-3983
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CP / N01 CP001012; United States / NCI NIH HHS / CP / N01 CP 01012; United States / NCI NIH HHS / CP / N01 CP 51010
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
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44. Kothandaraman N, Bajic VB, Brendan PN, Huak CY, Keow PB, Razvi K, Salto-Tellez M, Choolani M: E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. BMC Cancer; 2010;10:64
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  • Our hypothesis was supported by our tissue array experiments that showed E2F5 expression only in OEC samples but not in normal and benign tissues, and by significantly positively biased expression in serum samples done using western blotting studies.
  • E2F5 used in different combinations with CA125 for distinguishing malignant cyst from benign cyst shows that the presence of CA125 or E2F5 increases sensitivity of OEC detection to 97.9% (an increase from 87.5% if only CA125 is used) and, more importantly, the presence of both CA125 and E2F5 increases specificity of OEC to 72.5% (an increase from 55% if only CA125 is used).
  • Furthermore, detection of malignancy status in 86 cases (38 benign, 48 early and late OEC) shows that the use of E2F5 status in combination with other clinical characteristics allows for an improved detection of malignant cases with sensitivity, specificity, F-measure and accuracy of 97.92%, 97.37%, 97.92% and 97.67%, respectively.
  • [MeSH-major] E2F5 Transcription Factor / physiology. Gene Expression Regulation, Neoplastic. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Algorithms. Biomarkers, Tumor / metabolism. CA-125 Antigen / biosynthesis. Disease Progression. Female. Humans. Middle Aged. Neoplasm Metastasis. Reproducibility of Results. Sensitivity and Specificity


45. Abouzied MM, Crawford ES, Nabi HA: 18F-FDG imaging: pitfalls and artifacts. J Nucl Med Technol; 2005 Sep;33(3):145-55; quiz 162-3
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  • 18F-FDG PET is emerging as a useful tool in the staging and restaging of many malignant neoplasms, such as lymphoma, lung cancer, colorectal cancer, head and neck cancer, breast cancer, and melanoma.
  • To accurately interpret 18F-FDG findings one must be familiar with the normal physiologic distribution of the tracer, frequently encountered physiologic variants, and benign pathologic causes of 18F-FDG uptake that can be confused with a malignant neoplasm.
  • The objectives of this article are to (a) describe the mechanism of 18F-FDG uptake, (b) list the patient preparation and pertinent patient history before 18F-FDG imaging, (c) describe the whole-body physiologic distribution of 18F-FDG, (d) list and discuss normal physiologic variants, and (e) list and discuss benign pathologic causes of 18F-FDG uptake.
  • [MeSH-major] Artifacts. Diagnostic Errors / prevention & control. Fluorodeoxyglucose F18 / pharmacokinetics. Neoplasms / metabolism. Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods

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  • (PMID = 16145222.001).
  • [ISSN] 0091-4916
  • [Journal-full-title] Journal of nuclear medicine technology
  • [ISO-abbreviation] J Nucl Med Technol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 48
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46. Facina G, Lopes-Costa PV, Dos Santos AR, De Vasconcelos-Valença RJ, Pinho-Sobral AL, Ferreira-Filho CP, Alencar AP, Gebrim LH, Da Silva BB: Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast. Diagn Cytopathol; 2010 Apr;38(4):235-8
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  • [Title] Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast.
  • E-cadherin (EC) is an important glycoprotein cell-adhesion molecule that appears to play a significant role in the progression of breast lesions.
  • Samples of breast lesions from 44 women were used in this study, comprising cases of sclerosing adenosis (n = 11), ductal carcinoma in situ (DCIS) (n = 10) and invasive ductal carcinoma (n = 23).
  • There was a progressive loss of EC expression from benign to malignant lesions.
  • The present findings point to a significant association between reduced EC expression and the progression and aggressivity of breast lesions. Diagn. Cytopathol.
  • [MeSH-major] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Cadherins / metabolism. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Fibrocystic Breast Disease / metabolism. Fibrocystic Breast Disease / pathology

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  • (PMID = 19790246.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDH1 protein, human; 0 / Cadherins
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47. Eroğlu A, Sari A: Expression of c-kit proto-oncogene product in breast cancer tissues. Med Oncol; 2007;24(2):169-74
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  • [Title] Expression of c-kit proto-oncogene product in breast cancer tissues.
  • BACKGROUND: The published results on expression of c-kit in benign and malignant breast tissues vary.
  • MATERIALS AND METHODS: The immunohistochemical expression of c-kit proto-oncogene product in 52 invasive breast cancer tissues and 16 benign breast tumor (fibroadenoma) tissues was studied using anti-c-kit proto-oncogene product antibody.
  • RESULTS: In breast cancer tissues, the mean IRS of c-kit proto-oncogene product expression was significantly increased compared to those of fibroadenoma (3.4 +/- 2 and 2.19 +/- 1.8, respectively,p = 0.035).
  • The mean IRS of c-kit expression was higher in the group comprising estrogen (ER) positive tumor than in the group of ER negative (4.1 +/- 2.1 and 2.7 +/- 1.8, respectively,p = 0.012) but no statistically significant relationship was seen between the expression of c-kit proto-oncogene product and other clinicopathological parameters of breast cancer, including histologic type, tumor size, lymph node metastasis, distant metastasis, stage, progesterone receptor, c-erbB-2 expression, menopausal status and age of the patient (p > 0.05).
  • CONCLUSIONS: Our results show that a high level of c-kit expression occurs frequently in invasive breast cancer, and its expression is associated with ER but unrelated to other clinico-pathological variables.
  • [MeSH-major] Breast Neoplasms / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging

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  • (PMID = 17848740.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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48. Watermann DO, Földi M, Hanjalic-Beck A, Hasenburg A, Lüghausen A, Prömpeler H, Gitsch G, Stickeler E: Three-dimensional ultrasound for the assessment of breast lesions. Ultrasound Obstet Gynecol; 2005 Jun;25(6):592-8
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  • [Title] Three-dimensional ultrasound for the assessment of breast lesions.
  • OBJECTIVE: To evaluate the diagnostic accuracy of three-dimensional (3D) ultrasound in comparison with conventional two-dimensional (2D) ultrasound in the characterization of breast lesions.
  • METHODS: The digitally stored 2D ultrasound images and the corresponding 3D scans of 100 breast lesions (57 malignant, 43 benign) that had been morphologically classified as solid tumors, were independently analyzed by six investigators.
  • 3D ultrasound as an adjunct to conventional 2D ultrasound should be evaluated in larger trials to determine its clinical value in breast imaging.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Ultrasonography, Mammary / methods

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  • [Copyright] Copyright 2005 ISUOG
  • (PMID = 15912473.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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49. Chen G, Zou Q, Yang Z: [Expression of galectin-3 and Sambucus nigra agglutinin and its clinicopathological significance in benign and malignant lesions of breast]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2010 Jun;35(6):584-9
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  • [Title] [Expression of galectin-3 and Sambucus nigra agglutinin and its clinicopathological significance in benign and malignant lesions of breast].
  • OBJECTIVE: To detect the expression of galectin-3 (gal-3) and Sambucus nigra agglutinin (SNA) and determine their clinicopathological significance in breast cancers and benign breast lesions.
  • METHODS: Envison immunohistochemistry for staining gal-3 expression, and ABC affinity-cytochemistry to detect SNA expression were used in paraffin-embedded slides from specimens of breast cancers (n=60) and benign lesions (n=30).
  • RESULTS: The positive rates and scoring means of gal-3 and SNA were significantly higher in breast cancer (48.3%, 2.07 +/- 2.25, 2.12 +/- 2.26) than those in benign lesions (26.7%, 1.03 +/- 1.63, 1.07 +/- 1.59, P < 0.05).
  • The scoring means of gal-3 and SNA expression were significantly lower in the positive cases of estrogen receptor (ER) and the negative ones of CA15-3 than those in the negative cases and the positive ones (P < 0.05).The survival analysis of Kaplan-Meier showed the 5-year survival rate and mean survival period were significantly lower in the gal-3 or SNA expression positive cases than those in the negative cases of breast cancer (P<0.01).
  • CONCLUSION: The expressive level of gal-3 and SNA lectins might have important effect on the carcinogenesis, progression and biologic behaviors of breast cancer.
  • [MeSH-major] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Fibrocystic Breast Disease / metabolism. Galectin 3 / metabolism. Plant Lectins / metabolism. Ribosome Inactivating Proteins / metabolism

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  • (PMID = 20622331.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Mucin-1; 0 / Plant Lectins; 0 / Receptors, Estrogen; 0 / Sambucus nigra lectins; EC 3.2.2.22 / Ribosome Inactivating Proteins
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50. Gojnic M, Dugalic V, Vidaković S, Papic M, Jeremic K, Pervulov M, Milicevic S: Breast cancer and borderline ovarian carcinoma in young patients--case report. Eur J Gynaecol Oncol; 2005;26(5):579-80
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  • [Title] Breast cancer and borderline ovarian carcinoma in young patients--case report.
  • Cystosarcoma phyloides is a breast cancer with deterrent features because of its size and fast growth.
  • Regardless of the tumor type (serous, mucinous, clear cell, Brenner, mixed) they can be benign, borderline or malignant.
  • [MeSH-major] Breast Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis. Phyllodes Tumor / diagnosis


51. Al-Sindi K, Kamal N, Golbahar J: Efficacy of fine-needle aspiration biopsy in diagnosis of breast cancer: a retrospective study of 303 cases in Bahrain. Diagn Cytopathol; 2009 Sep;37(9):636-40
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  • [Title] Efficacy of fine-needle aspiration biopsy in diagnosis of breast cancer: a retrospective study of 303 cases in Bahrain.
  • Breast cancer is a leading cause of death in many countries worldwide and breast lesions remain a common diagnostic dilemma.
  • Fine-needle aspiration biopsy (FNAB) has been suggested as the most important, first line, minimally invasive measure in the management of patients with breast lesions.
  • The aim of this study is to evaluate the efficacy of FNAB in patients with breast lesions by comparing the diagnostic accuracy of cytology results with that of the definitive histological examination outcome and also to investigate the added value of a single aspirator experience to the overall diagnostic precision and compared with the internationally published results.
  • A retrospective study of 303 breast FNAB samples were carried out by a single experienced cytopathologist with complete comparison records.The prevalence of positive cytologic diagnosis for the breast cancer was determined to be 20.4%.
  • In addition, the sensitivity was comparable in cases that have been attempted by palpation-guided sampling compared with those aspirations that were carried out under US guidance.Results from this study confirm that FNAB biopsies performed and reported by a dedicated, single, skilled cytopathologist are highly effective in diagnosis of breast lesions and reliable in differentiating benign and malignant breast lesions with an overall high efficacy in a specialized laboratory-based FNAB clinic.
  • [MeSH-major] Breast Neoplasms / diagnosis

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19459172.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Kotsianos D, Wirth S, Fischer T, Hiltawsky K, Sittek H, Reiser M: [3D ultrasound (3D US) in the diagnosis of focal breast lesions]. Radiologe; 2005 Mar;45(3):237-44
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  • [Title] [3D ultrasound (3D US) in the diagnosis of focal breast lesions].
  • [Transliterated title] 3D-Ultraschall (3D-US) in der Diagnostik von Mammaherdbefunden.
  • BACKGROUND: It was to analyse whether 3D breast US is able to enhance the diagnosis of focal breast lesions.
  • RESULTS: 38 malignant and 22 benign lesions were analyzed.
  • Characteristics of benign solid masses included a round or oval shape as well as clearly defined and sharply demarcated margins.
  • CONCLUSIONS: 3D US allows to demonstrate breast masses in multiple planes.
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Ultrasonography, Mammary / methods

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  • (PMID = 15747149.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] Germany
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53. de Biase D, Morandi L, Degli Esposti R, Ligorio C, Pession A, Foschini MP, Eusebi V: p63 short isoforms are found in invasive carcinomas only and not in benign breast conditions. Virchows Arch; 2010 Apr;456(4):395-401
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  • [Title] p63 short isoforms are found in invasive carcinomas only and not in benign breast conditions.
  • Purpose of the study was to investigate the molecular expression of N-terminal p63 isoforms in benign and malignant breast tissues.
  • Eighteen randomly selected cases of invasive breast carcinoma (IBC) of luminal type, two cases of in situ duct carcinoma (DCIS/DIN), and 20 specimens of normal and benign breast tissues were studied.
  • All cases of normal breast, benign lesions, and the two cases of DCIS/DIN expressed DeltaNp63 and TAp63 isoforms only.
  • These isoforms were not observed in non-neoplastic breast tissue.
  • Presence of p63 in invasive breast carcinomas of luminal type, as seen at molecular level, suggests caution to include p63 as a marker of basal-like carcinomas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast / metabolism. Carcinoma, Intraductal, Noninfiltrating / metabolism. Exons / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Phenotype. Protein Isoforms / genetics. Protein Isoforms / metabolism

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  • (PMID = 20225093.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / Protein Isoforms
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54. Jung SY, Kang HS, Kwon Y, Min SY, Kim EA, Ko KL, Lee S, Kim SW: Risk factors for malignancy in benign papillomas of the breast on core needle biopsy. World J Surg; 2010 Feb;34(2):261-5
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  • [Title] Risk factors for malignancy in benign papillomas of the breast on core needle biopsy.
  • BACKGROUND: This study was designed to evaluate the clinical and pathologic parameters of benign papillomas diagnosed on core needle biopsy (CNB) and predict malignancy risk after surgical excision.
  • METHODS: We retrospectively reviewed clinicopathologic findings for 160 CNB-diagnosed benign papillomas followed by surgical excision from 154 patients.
  • RESULTS: Ten (6.3%) of the excised lesions were diagnosed as malignant.
  • In a CART analysis, including all variables, lesions that were palpable and associated with a mass on mammogram were confirmed as malignant.
  • CONCLUSIONS: Breast lesions diagnosed as benign papillomas on CNB had a 6.3% risk of being malignant.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma / pathology. Precancerous Conditions / pathology

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  • (PMID = 19997916.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Rangayyan RM, Oloumi F, Nguyen TM: Fractal analysis of contours of breast masses in mammograms via the power spectra of their signatures. Conf Proc IEEE Eng Med Biol Soc; 2010;2010:6737-40
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  • [Title] Fractal analysis of contours of breast masses in mammograms via the power spectra of their signatures.
  • Contours of benign breast masses and malignant tumors in mammograms differ substantially in their shape and complexity; the former are usually round and smooth, whereas the latter are typically spiculated and irregular.
  • We demonstrate the usefulness of fractal analysis via a frequency domain approach applied to one-dimensional signatures of the two-dimensional contours of breast masses.
  • Tests with a dataset of 111 contours, including those of 65 benign masses and 46 malignant tumors, indicated a high classification performance of 0.89 in terms of the area under the receiver operating characteristic curve.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography / methods

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  • (PMID = 21095828.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Youk JH, Kim EK, Kim MJ, Oh KK: Sonographically guided 14-gauge core needle biopsy of breast masses: a review of 2,420 cases with long-term follow-up. AJR Am J Roentgenol; 2008 Jan;190(1):202-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonographically guided 14-gauge core needle biopsy of breast masses: a review of 2,420 cases with long-term follow-up.
  • OBJECTIVE: The objective of our study was to determine the diagnostic accuracy of sonographically guided core needle biopsy for breast masses by evaluating the outcomes of benign biopsies that had at least a 2-year follow-up.
  • RESULTS: The pathologic results for the core needle biopsies were malignant in 52%, high-risk in 4%, and benign in 44%.
  • Of 1,071 benign lesions, malignancy was found at rebiopsy in 31 lesions (25 immediate and six delayed false-negative diagnoses), and the false-negative rate was 2.4% (31 of 1,312).
  • CONCLUSION: Sonographically guided 14-gauge core needle biopsy is an accurate method for evaluating breast masses.
  • Imaging-pathologic correlation and follow-up of benign biopsy are essential for a successful breast biopsy program.
  • [MeSH-major] Biopsy, Needle / methods. Breast Diseases / pathology. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Ultrasonography, Mammary

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  • (PMID = 18094312.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Noguera J, Martínez-Miravete P, Idoate F, Díaz L, Pina L, Zornoza G, Martínez-Regueira F: Metastases to the breast: a review of 33 cases. Australas Radiol; 2007 Apr;51(2):133-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastases to the breast: a review of 33 cases.
  • The aim of the study was to show the clinical and radiological manifestations of metastases to the breast (MB).
  • Of the 33 cases, 31 presented as a palpable breast lump.
  • Mammograms were normal in six cases (all of them showed dense breast tissue).
  • The appearance on magnetic resonance was similar to primary breast cancer (one case).
  • Metastases to the breast showed a wide range of mammographic and ultrasonographic appearances, resembling both benign and malignant lesions.
  • Any patient who presents with a breast lump with a history of cancer should undergo a core-needle biopsy in order to determine the histology of the lump.
  • [MeSH-major] Breast Neoplasms / secondary

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  • (PMID = 17419856.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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58. Uematsu T, Kasami M, Yuen S: Usefulness and limitations of the Japan Mammography Guidelines for the categorization of microcalcifications. Breast Cancer; 2008;15(4):291-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The Japan Mammography Guidelines, referred to the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS), are intended to standardize the terminology in mammographic reports and the assessment of findings and to recommend action to be taken.
  • METHODS: A retrospective review was performed of 101 non-palpable screening mammography-detected microcalcification lesions without mass that had stereotactic vacuum-assisted breast biopsy (SVAB).
  • RESULTS: In calcification morphology, all 32 punctate morphology microcalcifications, regardless of distribution, were benign (100%), whereas 25% (9/36) amorphous morphology microcalcifications, 67% (14/21) pleomorphic morphology microcalcifications and 92% (11/12) linear morphology microcalcifications were malignant.
  • For calcification distribution, 28% (15/55) cluster distribution microcalcifications, 40% (17/43) segmental distribution microcalcifications and 67% (2/3) linear distribution microcalcifications were malignant.
  • [MeSH-major] Breast Neoplasms / classification. Breast Neoplasms / radiography. Calcinosis / classification. Calcinosis / radiography. Mammography / utilization. Practice Guidelines as Topic / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Ductal, Breast / classification. Carcinoma, Ductal, Breast / radiography. Carcinoma, Intraductal, Noninfiltrating / classification. Carcinoma, Intraductal, Noninfiltrating / radiography. Diagnosis, Differential. False Positive Reactions. Female. Humans. Japan. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Ultrasonography, Mammary

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  • (PMID = 18288569.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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59. Ohlinger R, Heyer H, Thomas A, Paepke S, Warm H, Klug U, Frese H, Schulz K, Schimming A, Schwesinger G, Köhler G, Wodny M, Kohlmann T, Grunwald S: Non-palpable breast lesions in asymptomatic women: diagnostic value of initial ultrasonography and comparison with mammography. Anticancer Res; 2006 Sep-Oct;26(5B):3943-55
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  • [Title] Non-palpable breast lesions in asymptomatic women: diagnostic value of initial ultrasonography and comparison with mammography.
  • AIM: This prospective double-blind study was designed to assess (i) if primary breast screening by ultrasonography is capable of detecting breast cancer independent of tissue density and (ii) if the rate of unnecessary biopsies remains acceptable when diagnostics are based on ultrasonography.
  • PATIENTS AND METHODS: Bilateral breast ultrasonography was performed in 448 asymptomatic women as the initial diagnostic method.
  • RESULTS: Overall, 3 non-palpable breast cancers were detected by ultrasound and mammography.
  • All 3 ultrasonographically detected breast cancers were smaller than 1 cm (0.7, 0.7, 0.6 cm).
  • The ratio of benign to malignant lesions was 3.7/1.
  • CONCLUSION: Without prior mammography, primary high-resolution breast ultrasonography is capable of detecting non-palpable breast carcinomas in asymptomatic women at an early stage.
  • The rate of unnecessary open biopsies is low and the ratio of benign to malignant biopsies acceptable.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography

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  • (PMID = 17094426.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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60. Ding JH, Peng WJ, Jiang ZX, Xu LH, Hu DT, Zheng XJ: [Diagnostic value of full-field digital mammography for breast carcinoma]. Zhonghua Zhong Liu Za Zhi; 2009 Nov;31(11):854-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic value of full-field digital mammography for breast carcinoma].
  • OBJECTIVE: To evaluate the diagnostic value of full-field digital mammography for breast cancer.
  • METHODS: The clinical data and mammograms of 230 patients with breast diseases between January 2008 and July 2008 were collected and reviewed.
  • Three experienced radiologists in breast imaging assessment analyzed and classified all the mammograms according to breast imaging reporting and data system (BI-RADS).
  • RESULTS: Of the 238 samples, 130 had a malignant breast tumors and 108 cases of benign breast lesions.
  • One hundred and nine of the 130 malignant breast tumors were invasive ductal carcinoma.
  • Fifty-seven of the 108 benign breast lesions were breast adenosis.
  • Masses or masses with microcalcification were the most frequently seen signs of the malignant tumors, accounting for 40.8% and 20.8%, respectively.
  • The sensitivity, specificity and accuracy of FFDM in detecting breast carcinoma were 90.8%, 87.0% and 89.1%, respectively.
  • The false-positive signs were masses with spiculate, indistinctive or lobulated margin leading to misdiagnosing the lesions as malignant tumors.
  • CONCLUSION: Full-field digital mammography (FFDM) is helpful in detection of breast cancers in women, with a higher sensitivity, specificity and accuracy, and has an important clinical application value.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Fibrocystic Breast Disease / diagnosis. Mammography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Diseases / diagnosis. Breast Diseases / radiography. Calcinosis / diagnosis. Calcinosis / radiography. Diagnostic Errors. Female. Humans. Middle Aged. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • (PMID = 20137352.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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61. Sardanelli F, Fausto A, Esseridou A, Di Leo G, Kirchin MA: Gadobenate dimeglumine as a contrast agent for dynamic breast magnetic resonance imaging: effect of higher initial enhancement thresholds on diagnostic performance. Invest Radiol; 2008 Apr;43(4):236-42
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  • [Title] Gadobenate dimeglumine as a contrast agent for dynamic breast magnetic resonance imaging: effect of higher initial enhancement thresholds on diagnostic performance.
  • RATIONALE AND OBJECTIVE: Gadobenate dimeglumine (Gd-BOPTA), a high-relaxivity contrast agent, has been recently proposed for dynamic MR imaging of the breast.
  • The objective of this study was to optimize the diagnostic performance of Gd-BOPTA-enhanced dynamic breast MR imaging by using adjusted initial enhancement thresholds.
  • METHODS: Thirty-four patients with 36 breast lesions (malignant/benign = 28/8) underwent dynamic breast MRI with 0.1 mmol/kg Gd-BOPTA and 120-second time resolution.
  • Scores of 0 to 3 indicated benign lesions and scores of 4 to 8 malignant lesions.
  • RESULTS: The initial enhancement was >100% for 26 malignant and 7 benign lesions and >240% for 16 and 1 lesions, respectively.
  • The overall score was 5.89 +/- 1.34 with standard thresholds and 5.50 +/- 1.53 with adjusted thresholds (P = 0.003) for cancers, 4.00 +/- 1.93 and 3.25 +/- 1.75 (P = 0.028) for benign lesions, respectively.
  • [MeSH-major] Breast Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Meglumine / analogs & derivatives. Organometallic Compounds

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  • (PMID = 18340247.001).
  • [ISSN] 0020-9996
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
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62. Yücesoy C, Oktay NA, Oztürk E, Oktay M, Hücümenoğlu S, Alper M, Hekimoğlu B: Pathologic assessment of non-palpable probably benign breast masses at sonography: can instant intervention be avoided and is follow-up adequate? JBR-BTR; 2010 Sep-Oct;93(5):242-6
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  • [Title] Pathologic assessment of non-palpable probably benign breast masses at sonography: can instant intervention be avoided and is follow-up adequate?
  • AIM OF THE STUDY: To evaluate the pathologic results, determine the negative predictive value of non-palpable probably benign lesions at ultrasound and asses whether follow-up is adequate and immediate biopsy can be avoided.
  • MATERIALS AND METHODS: Four hundred and eight cases which were referred to our breast imaging unit between 2004 and 2008 for biopsy evaluation were enrolled into the study.
  • Two hundred and thirteen probably benign solid masses are classified as BI-RADS 3 in 205 of the enrollees.
  • Finally, 211 of the punctured lesions turned out to be benign and only two malignant lesions were detected.
  • CONCLUSION: With the results provided, we think that in the patients with sonographically detected probably benign breast lesions, short-term follow-up seems to be a strong alternative to immediate biopsy with its reliable high negative predictivity as well as low false negativity.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Ultrasonography, Mammary / methods

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  • (PMID = 21179983.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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63. Ceçener G, Egeli U, Tunca B, Taşdelen I, Tolunay S, Bilgel N: Importance of novel sequence alterations in the FHIT gene on formation of breast cancer. Tumori; 2007 Nov-Dec;93(6):597-603
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  • [Title] Importance of novel sequence alterations in the FHIT gene on formation of breast cancer.
  • AIMS AND BACKGROUND: The character, role and impact of FHIT gene alterations, for which recent studies have shown that the gene has a role in the early stage of carcinogenesis in breast cancer, are still unclear.
  • Thus, the current study evaluated FHIT gene mutations from breast tissue of women with malignant and benign breast disease and to elucidate the frequency and type of mutations in this gene.
  • PATIENTS AND METHODS: Mutations in exons 5-9 of the FHIT gene were screened using the intronic primer pairs in 83 breast (67 malignant and 16 benign) tissue samples by single-strand conformational polymorphism and sequencing analysis.
  • RESULTS: FHIT mutations were detected in 13 of the 67 malignant cases (19.4%) and 2 of the 16 benign cases (12.5%).
  • CONCLUSIONS: Our data contribute significantly to that currently known about the presence of FHIT gene mutations on the formation of breast cancer.
  • [MeSH-major] Acid Anhydride Hydrolases / genetics. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Mutation. Neoplasm Proteins / genetics

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  • (PMID = 18338496.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; 0RH81L854J / Glutamine; 2ZD004190S / Threonine; 47E5O17Y3R / Phenylalanine; EC 3.6.- / Acid Anhydride Hydrolases; OF5P57N2ZX / Alanine
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64. Guliato D, Rangayyan RM, Daloia de Carvalho J, Anchieta Santiago S: Spiculation-preserving polygonal modeling of contours of breast tumors. Conf Proc IEEE Eng Med Biol Soc; 2006;1:2791-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spiculation-preserving polygonal modeling of contours of breast tumors.
  • Malignant breast tumors typically appear in mammograms with rough, spiculated, or microlobulated contours, whereas most benign masses have smooth, round, oval, or macrolobulated contours.
  • Several studies have shown that shape factors that incorporate differences as above can provide high accuracies in distinguishing between malignant tumors and benign masses based upon their contours only.
  • The methods were tested with a set of 111 contours of 65 benign masses and 46 malignant tumors.
  • [MeSH-major] Algorithms. Breast Neoplasms / radiography. Imaging, Three-Dimensional / methods. Mammography / methods. Pattern Recognition, Automated / methods. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 17945740.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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65. Waliszewski SM, Bermudez MT, Infanzon RM, Silva CS, Carvajal O, Trujillo P, Gomez Arroyo S, Villalobos Pietrini R, Saldaña VA, Melo G, Esquivel S, Castro F, Ocampo H, Torres J, Hayward-Jones PM: Persistent organochlorine pesticide levels in breast adipose tissue in women with malignant and benign breast tumors. Bull Environ Contam Toxicol; 2005 Oct;75(4):752-9
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  • [Title] Persistent organochlorine pesticide levels in breast adipose tissue in women with malignant and benign breast tumors.
  • [MeSH-major] Adipose Tissue / chemistry. Breast Neoplasms / chemically induced. Breast Neoplasms / metabolism. Hydrocarbons, Chlorinated / analysis. Pesticides / analysis
  • [MeSH-minor] Adult. Breast / metabolism. Case-Control Studies. Female. Humans. Mexico / epidemiology. Middle Aged. Risk

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  • (PMID = 16400557.001).
  • [ISSN] 0007-4861
  • [Journal-full-title] Bulletin of environmental contamination and toxicology
  • [ISO-abbreviation] Bull Environ Contam Toxicol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydrocarbons, Chlorinated; 0 / Pesticides
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66. Farshid G, Pieterse S: Core imprint cytology of screen-detected breast lesions is predictive of the histologic results. Cancer; 2006 Jun 25;108(3):150-6
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  • [Title] Core imprint cytology of screen-detected breast lesions is predictive of the histologic results.
  • BACKGROUND: In multidisciplinary assessment clinics for screen-detected breast lesions, onsite cytopathologists provide immediate results of fine-needle aspiration biopsies (FNABs) and this information is used for patient counseling and treatment planning.
  • If core imprint cytology (CIC) of breast cores can be shown to be reliable in a significant proportion of screen-detected lesions, this technique may be of clinical value in such clinics.
  • METHODS: In the setting of a large, accredited, population-based breast cancer screening program, prospective results of CIC were gathered on 567 lesions and correlated with the results of core biopsy to determine the performance indicators for CIC.
  • False-negative imprints are a greater challenge, with 13.6% of malignant lesions producing benign-appearing or acellular imprints.
  • In particular, the results of acellular imprints are analogous to benign CIC findings for microcalcifications but not in parenchymal lesions.
  • Breast CIC is a reliable predictor of core histology.
  • [MeSH-major] Breast Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / pathology. False Negative Reactions. False Positive Reactions. Female. Humans. Mammography. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 16634070.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Abdalla FB, Boder JM, Buhmeida A, Elzagheid AI, Collan Y: Image DNA cytometry in FNABs of Libyan breast disease. Anticancer Res; 2010 Jan;30(1):175-81
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  • [Title] Image DNA cytometry in FNABs of Libyan breast disease.
  • BACKGROUND: The sensitivity for identification of malignant cells in conventional fine-needle aspiration biopsy (FNAB) investigation is about 80%.
  • This percentage is dependent on the number of examined cells, type of breast cancer, and experience of the examiner.
  • The aim of our study was to estimate the supporting value of image DNA cytometry of FNAB of the breast, and do so by using different sampling methods.
  • MATERIALS AND METHODS: This retrospective study was based on 41 cases with an available histological diagnosis: 18 benign lesions and 23 malignant tumours were examined.
  • RESULTS: All non-malignant cases had diploid histogram.
  • Most histologically malignant cases were aneuploid.
  • All samples with aneuploid histograms were malignant.
  • CONCLUSION: The results confirm earlier published data in the Finnish population and indicate that image DNA cytometric analysis of nuclear content is a useful marker for identification of malignant cells in FNAB, especially after free cell sampling.
  • The method can be used to increase the cytological sensitivity and specificity in doubtful breast lesions.
  • [MeSH-major] Breast Neoplasms / genetics. Breast Neoplasms / pathology. DNA, Neoplasm / analysis. Image Cytometry / methods

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  • (PMID = 20150633.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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68. Li H, Lu Q, Dong LH, Xue H, Zhou HY, Yang HJ: [Expression of fatty acid binding protein in human breast cancer tissues]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2007 Apr;23(4):312-6
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  • [Title] [Expression of fatty acid binding protein in human breast cancer tissues].
  • AIM: To detect the expression pattern of fatty acid binding protein (FABP) in human breast cancer, and to find potential markers and therapeutic targets for breast cancer.
  • METHODS: adipocyte-FABP (A-FABP), heart or muscle FABP (H-FABP), brain-FABP (B-FABP), epidermis or psoriasis FABP (E-FABP), liver FABP (L-FABP), intestinal FABP (I-FABP) and gastro-FABP (G-FABP) expression in 35 ductal infiltrating carcinoma and 16 fibroadenoma of breast were detected by RT-PCR, immunohistochemical staining and Western blot analysis, respectively.
  • RESULTS: E-, L-, and H-FABP were up regulated significantly in ductal infiltrating carcinoma when compared with those in benign tissue (P<0.05).
  • However, there were not significant difference in A-, B-, G-, and I-FABP expression between ductal infiltrating carcinoma and benign tissue (P>0.05).
  • Interestingly, H-FABP was not only found in benign tissues but in some of ductal infiltrating carcinomas, furthermore, H-FABP level was elevated in malignant tissue, compared with that in benign tissue.
  • CONCLUSION: E-, L-, and H-FABP may play a key role in the progress of invasiveness and metastasis in human breast cancer.
  • Furthermore, the secretion of these FABPs has the potential to serve as a diagnostic marker for breast cancer.
  • [MeSH-major] Breast Neoplasms / metabolism. Fatty Acid-Binding Proteins / genetics. Fatty Acid-Binding Proteins / metabolism

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  • (PMID = 17428383.001).
  • [ISSN] 1007-8738
  • [Journal-full-title] Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
  • [ISO-abbreviation] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Fatty Acid-Binding Proteins
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69. Barranger E, Morel O, Coutant C, Delpech Y, Uzan S: [Surgical management of breast microclacifications]. J Gynecol Obstet Biol Reprod (Paris); 2007 Sep;36(5):468-72
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  • [Title] [Surgical management of breast microclacifications].
  • [Transliterated title] Stratégie de prise en charge chirurgicale des microcalcifications du sein.
  • The breast infraclinic lesions, as microcalcifications, are images found very often within the framework of the tracking of the breast cancer.
  • The majority of them correspond to benign lesions.
  • Thus, the percutaneous procedure performed under local anaesthesia give the possibility of avoiding an useless intervention for a benign lesion, or of avoiding, for a malignant lesion, an operational time with aiming diagnoses followed by a therapeutic surgical recovery.
  • The stereotaxic percutaneous procedures, by confirming a invasive malignant lesion, also follow to perform sentinel lymph node biopsy, or to program an axillary dissection.
  • It also can in the event of large infraclinic lesion, confirmed by two macrobiopsies spaced of more than 3 cm, to perform a mastectomy associated to immediate breast surgical reconstruction.
  • [MeSH-major] Breast / pathology. Breast Diseases / surgery. Breast Neoplasms / surgery. Calcinosis / surgery

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  • (PMID = 17555888.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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70. Büchler T, Vorzilková E, Koukolík F, Melínova H, Abrahámová J: [Malignant subtype of cystosarcoma phyllodes with brain metastases]. Klin Onkol; 2010;23(6):446-8
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  • [Title] [Malignant subtype of cystosarcoma phyllodes with brain metastases].
  • Cystosarcoma phyllodes is an uncommon type of breast tumour.
  • Benign, borderline, and malignant subtypes have been described.
  • Central nervous system metastases of the malignant subtype of cystosarcoma phyllodes are rare and associated with poor prognosis.
  • We report on a patient with malignant cystosarcoma phyllodes who developed metastatic disease six years after resection of the primary breast tumour.
  • Because metastatic malignant cystosarcoma phyllodes are largely resistant to treatment, the most important objective is to provide optimal management of the primary tumour before dissemination occurs.
  • [MeSH-major] Brain Neoplasms / secondary. Breast Neoplasms / pathology. Phyllodes Tumor / secondary

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  • (PMID = 21351423.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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71. Fernández-Aguilar S, Noël JC: [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report]. Ann Pathol; 2007 Feb;27(1):31-4
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  • [Title] [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report].
  • [Transliterated title] Tumeur phyllode maligne du sein avec cellules géantes de type ostéoclastique: à propos d'un cas.
  • Breast tumors, particularly of stromal origin, containing multinucleated osteoclast-like giant cells (OLGC) are rarely reported in the literature.
  • We report here the first case of a malignant phyllodes tumor associated with OLGC occurring in a 43 year-old African woman who presented with a painful palpable mass of the outer upper quadrant of the right breast.
  • After surgical excision, histological examination showed a malignant phyllodes tumor in which the stromal component displayed evident sarcomatous changes and was densely populated with benign multinucleated OLGC.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology. Phyllodes Tumor / pathology

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  • (PMID = 17568357.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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72. Leff DR, Warren OJ, Enfield LC, Gibson A, Athanasiou T, Patten DK, Hebden J, Yang GZ, Darzi A: Diffuse optical imaging of the healthy and diseased breast: a systematic review. Breast Cancer Res Treat; 2008 Mar;108(1):9-22
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  • [Title] Diffuse optical imaging of the healthy and diseased breast: a systematic review.
  • Reviews of optical breast imaging have not been systematic, are focused mainly on technological developments, and have become superseded by rapid technological advancement.
  • The aim of this study is to review clinically orientated studies involving approximately 2,000 women in whom optical mammography has been used to evaluate the healthy or diseased breast.
  • The results suggest that approximately 85% of breast lesions are detectable on optical mammography.
  • Spectroscopic resolution of tissue haemoglobin composition and oxygen saturation may improve the detectability of breast diseases.
  • Results suggest that breast lesions contain approximately twice the haemoglobin concentration of background tissue.
  • Current evidence suggests that it is not possible to distinguish benign from malignant disease using optical imaging techniques in isolation.
  • [MeSH-major] Breast Neoplasms / radiography. Diagnostic Imaging / methods. Infrared Rays. Mammography / methods. Mass Screening / methods

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  • (PMID = 17468951.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 61
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73. Taira N, Takabatake D, Aogi K, Ohsumi S, Takashima S, Nishimura R, Teramoto N: Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin. Jpn J Clin Oncol; 2007 Oct;37(10):730-6
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  • [Title] Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin.
  • Pathologic diagnoses were benign, borderline and malignant in 31, five and nine cases, respectively, and the surgical stump was negative in 27 lesions and positive in 15.
  • In univariate analysis, a positive surgical margin, stromal overgrowth and histological classification were predictive factors for local recurrence after breast-conservation surgery (P = 0.0034, 0.0003, 0.026).
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Neoplasm Recurrence, Local / prevention & control. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

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  • (PMID = 17932112.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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74. La Vecchia C, Bosetti C: Oral contraceptives and neoplasms other than breast and female genital tract. Eur J Cancer Prev; 2009 Sep;18(5):407-11
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  • [Title] Oral contraceptives and neoplasms other than breast and female genital tract.
  • We reviewed epidemiological data on oral contraceptive (OC) use and colorectal, liver, lung and other nonfemale neoplasms.
  • Current, but not past, OC use is associated with excess risk of benign liver tumours, and a modest excess risk of liver cancer.
  • There was no evidence of an association between OC use and lung, digestive tract neoplasms other than colorectum, cutaneous malignant melanoma, thyroid cancer and any of the other neoplasms investigated.
  • [MeSH-major] Colorectal Neoplasms / epidemiology. Contraceptives, Oral / therapeutic use. Liver Neoplasms / epidemiology. Lung Neoplasms / epidemiology
  • [MeSH-minor] Breast Neoplasms / epidemiology. Female. Genital Neoplasms, Female / epidemiology. Humans. Neoplasms / epidemiology

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  • (PMID = 19609214.001).
  • [ISSN] 1473-5709
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contraceptives, Oral
  • [Number-of-references] 49
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75. Cross SS, Yang Z, Brown NJ, Balasubramanian SP, Evans CA, Woodward JK, Neville-Webbe HL, Lippitt JM, Reed MW, Coleman RE, Holen I: Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int J Cancer; 2006 Apr 15;118(8):1901-8
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  • Investigation of various human cancers demonstrated endothelial OPG expression in 59% of malignant tumours (n=512), but in contrast, OPG was absent in endothelial cells associated with benign tumours and normal tissues (n=178).
  • In a series of 400 breast tumours, endothelial OPG expression was associated with high tumour grade and certain histological types.
  • Our data show a clear separation in endothelial OPG expression between malignant tumours and nonmalignant tissues, supporting a potential biological role for this molecule in the development and/or maintenance of the tumour vasculature.
  • [MeSH-major] Breast Neoplasms / blood supply. Breast Neoplasms / genetics. Endothelial Cells / physiology. Glycoproteins / physiology. Neovascularization, Pathologic. Receptors, Cytoplasmic and Nuclear / physiology. Receptors, Tumor Necrosis Factor / physiology

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16287088.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / Osteoprotegerin; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Tumor Necrosis Factor; 0 / TNFRSF11B protein, human
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76. Vadalà R, Polito R, Fiorucci C, Costantini M, Romani M, Belli P: A case of primary breast lymphoma. Rays; 2005 Jul-Sep;30(3):233-7
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  • [Title] A case of primary breast lymphoma.
  • The case of a patient with a lesion in the right breast, is discussed.
  • Retrospective evaluation of mammography and US previously performed elsewhere were not fully helpful in the differential diagnosis between benign and malignant and MRI was necessary.
  • Morphological and dynamic characteristics could be indicative of an expansive/infiltrating lesion of the breast and support the staging.
  • The histological examination established the diagnosis of primary breast lymphoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Lymphoma / diagnosis

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  • (PMID = 16512069.001).
  • [ISSN] 0390-7740
  • [Journal-full-title] Rays
  • [ISO-abbreviation] Rays
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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77. Athanasiou A, Vanel D, Fournier L, Balleyguier C: Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation. Cancer Imaging; 2007;7:34-40
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  • [Title] Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation.
  • The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 4-5 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference.
  • The patient's breast was positioned onto a panel of red light-emitting diodes (640 nm).
  • A soft membrane was inflated to exert a uniform pressure on the breast.
  • Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign.
  • Seventy-eight women consulting for non-palpable breast lesions were initially included in the study.
  • We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS).
  • False positive results were seen in benign proliferative lesions.
  • Dynamic optical breast imaging is a novel, low-cost, non-invasive technique yielding a new type of information about the physiology of breast lesions.
  • Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Spectroscopy, Near-Infrared / methods. Transillumination / methods
  • [MeSH-minor] Absorption. Adult. Aged. Breast Diseases / radiography. Calcinosis / diagnosis. Calcinosis / pathology. Diagnosis, Differential. Equipment Design. False Negative Reactions. Female. Hemoglobins / analysis. Humans. Middle Aged. Neovascularization, Pathologic / diagnosis. Neovascularization, Pathologic / pathology. Palpation. Prospective Studies. Sensitivity and Specificity. Severity of Illness Index

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  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
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78. Conde I, Lobo MV, Zamora J, Pérez J, González FJ, Alba E, Fraile B, Paniagua R, Arenas MI: Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. BMC Cancer; 2008;8:174
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  • [Title] Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha.
  • We have investigated the expression of hPXR and RXRs in normal, premalignant, and malignant breast tissues, in order to determine whether their expression profile in localized infiltrative breast cancer is associated with an increased risk of recurrent disease.
  • METHODS: Breast samples from 99 patients including benign breast diseases, in situ and infiltrative carcinomas were processed for immunohistochemistry and Western-blot analysis.
  • CONCLUSION: Breast cancer cells can express both variants 1 and 2 of hPXR.
  • [MeSH-major] Breast Neoplasms / metabolism. Receptors, Steroid / biosynthesis. Retinoid X Receptor alpha / metabolism. Retinoid X Receptors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Dimerization. Disease-Free Survival. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging

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  • (PMID = 18565212.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Steroid; 0 / Retinoid X Receptor alpha; 0 / Retinoid X Receptors; 0 / pregnane X receptor
  • [Other-IDs] NLM/ PMC2442113
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79. Drukker K, Pesce L, Giger M: Repeatability in computer-aided diagnosis: application to breast cancer diagnosis on sonography. Med Phys; 2010 Jun;37(6):2659-69
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeatability in computer-aided diagnosis: application to breast cancer diagnosis on sonography.
  • PURPOSE: The aim of this study was to investigate the concept of repeatability in a case-based performance evaluation of two classifiers commonly used in computer-aided diagnosis in the task of distinguishing benign from malignant lesions.
  • METHODS: The authors performed .632+ bootstrap analyses using a data set of 1251 sonographic lesions of which 212 were malignant.
  • [MeSH-major] Algorithms. Breast Neoplasms / diagnostic imaging. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Pattern Recognition, Automated / methods. Ultrasonography, Mammary / methods

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  • (PMID = 20632577.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA125183; United States / NCI NIH HHS / CA / R01-CA89452; United States / NCI NIH HHS / CA / P50-CA125183; United States / NCI NIH HHS / CA / R21 CA113800; United States / NCI NIH HHS / CA / R21-CA113800; United States / NCI NIH HHS / CA / R01 CA089452
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2885941
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80. Sato K, Ueda Y, Shimasaki M, Ozaki M, Nitta N, Chada K, Ishikawa Y, Katsuda S: Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. Pathol Res Pract; 2005;201(4):333-9
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  • [Title] Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature.
  • We report a case of pleomorphic adenoma (benign mixed tumor) of the breast, which is an extremely rare location for this tumor.
  • Examination of a 55-year-old woman unexpectedly revealed a mass measuring 0.8 cm in diameter in the subareolar region of the right breast.
  • Sixty-nine cases of this type of tumor arising in the breast have been described previously.
  • Using imaging procedures, the tumor has occasionally been misdiagnosed as malignant clinically and even pathologically in frozen section diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology

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  • (PMID = 15991841.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / Receptors, Estrogen; 124544-67-8 / HMGA1a Protein
  • [Number-of-references] 32
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81. Toomey DP, Cahill RA, Birido N, Jeffers M, Loftus B, McInerney D, Rothwell J, Geraghty JG: Rapid assessment breast clinics--evolution through audit. Eur J Cancer; 2006 Nov;42(17):2961-7
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  • [Title] Rapid assessment breast clinics--evolution through audit.
  • This observational, cohort study aimed to examine the potential utility of Rapid Assessment Breast Clinics (RABC) beyond cancer detection at presentation.
  • 154 (10.7%) had breast cancer - 87.7% of whom were seen expediently with 92.9% being diagnosed at one attendance.
  • One hundred and forty three (10%) of those with a benign diagnosis were found by routine questioning to have significant familial risk separate to their reason for referral.
  • One hundred and seventy six attendees (12.3%) had neither the symptom that triggered referral, nor breast lump, nipple discharge nor family history of breast cancer, while 283 (19.8%) had no objective clinical or radiological abnormality.
  • Although RABC reliably categorise malignant versus non-malignant diagnoses despite cluttering by low risk women, a significant proportion of non-cancer patients still require address of future risk rather than reassurance of their present status alone.
  • [MeSH-major] Ambulatory Care / standards. Breast Neoplasms / diagnosis. Hospitals, Special

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  • (PMID = 16956758.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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82. Rojas-Domínguez A, Nandi AK: Development of tolerant features for characterization of masses in mammograms. Comput Biol Med; 2009 Aug;39(8):678-88
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  • In this paper, four new features for the analysis of breast masses are presented.
  • The features were tested for characterization (i.e. discrimination between circumscribed and spiculated masses) and diagnosis (i.e. discrimination between benign and malignant masses) of breast masses using a set of 319 masses and three different classifiers.
  • [MeSH-minor] Algorithms. Breast / pathology. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Early Detection of Cancer. False Positive Reactions. Female. Humans. Models, Statistical. Models, Theoretical. Neural Networks (Computer). Reproducibility of Results. Software

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  • (PMID = 19524221.001).
  • [ISSN] 1879-0534
  • [Journal-full-title] Computers in biology and medicine
  • [ISO-abbreviation] Comput. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Cook AC, Tuck AB, McCarthy S, Turner JG, Irby RB, Bloom GC, Yeatman TJ, Chambers AF: Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression. Mol Carcinog; 2005 Aug;43(4):225-36
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  • [Title] Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression.
  • Tumor progression is a multistep process, which enables cells to evolve from benign to malignant tumors.
  • Here we studied genes regulated by OPN in a model of human breast cancer using oligonucleotide microarray technology by comparing the gene-expression profiles of 21NT mammary carcinoma cells transfected to overexpress OPN versus mock-transfected control cells.
  • This study provides the first evidence that OPN can lead to numerous gene expression changes that influence multiple aspects of tumor progression and malignant growth.
  • [MeSH-major] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Gene Expression Regulation, Neoplastic / drug effects. Sialoglycoproteins / pharmacology

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 15864800.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K24-CA85429; United States / NCI NIH HHS / CA / U01-CA85052
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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84. Chen YW, Chuang YW, Lai YC, Hsieh JS, Liu GC, Hou MF: Is early dynamic lymphoscintigraphy for detection of sentinel lymph nodes always achievable in breast tumor? Ann Nucl Med; 2006 Jan;20(1):45-50
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  • [Title] Is early dynamic lymphoscintigraphy for detection of sentinel lymph nodes always achievable in breast tumor?
  • OBJECTIVE: In this article, we will discuss the achievement of early dynamic lymphoscintigraphic protocol and compare detection of sentinel node between benign and malignant breast tumors, and whether pathologic factor is related or not.
  • The average age of patients was 47.6 +/- 9.8 years and all of them were clinically suspected of having breast cancer.
  • RESULTS: Among 59 patients, 14 of them were diagnosed with fibroadenoma and the other 45 cases with malignant conditions, infiltrating duct carcinoma mostly.
  • From the summation image of dynamic study, identified axillary sentinel nodal activity was found as 80% in the group of benign breast tumor, but only 48% in the group of malignant breast tumor.
  • However, this short period of protocol is not always achievable to detect sentinel node, especially in the group with breast malignant lesions.
  • [MeSH-major] Breast Neoplasms / radionuclide imaging. Breast Neoplasms / secondary. Lymph Nodes / pathology. Lymph Nodes / radionuclide imaging. Sentinel Lymph Node Biopsy / methods

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  • (PMID = 16485574.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid
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85. Thomas A, Degenhardt F, Farrokh A, Wojcinski S, Slowinski T, Fischer T: Significant differentiation of focal breast lesions: calculation of strain ratio in breast sonoelastography. Acad Radiol; 2010 May;17(5):558-63
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  • [Title] Significant differentiation of focal breast lesions: calculation of strain ratio in breast sonoelastography.
  • RATIONALE AND OBJECTIVES: Initial data suggest that elastography can improve the specificity of ultrasound in differentiating benign and malignant breast lesions.
  • The aim of this study was to compare elastography and B-mode ultrasound to determine whether the calculation of strain ratios (SRs) can further improve the differentiation of focal breast lesions.
  • MATERIALS AND METHODS: A total of 227 women with histologically proven focal breast lesions (113 benign, 114 malignant) were included at two German breast centers.
  • B-mode scans and sonoelastograms were analyzed by two experienced readers using the Breast Imaging Reporting and Data System criteria.
  • An SR cutoff value of 2.45 (area under the curve, 0.949) allowed significant differentiation (P < .001) of malignant (mean, 5.1 +/- 4.2) and benign (mean, 1.6 +/- 1.0) lesions.
  • CONCLUSIONS: Calculation of SRs contributes to the standardization of sonoelastography with high sensitivity and allows significant differentiation of benign and malignant breast lesions with higher specificity compared to B-mode ultrasound but not elastography.
  • [MeSH-major] Breast Neoplasms / physiopathology. Breast Neoplasms / ultrasonography. Elasticity Imaging Techniques / methods. Ultrasonography, Mammary / methods

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  • [Copyright] Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20171905.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Keyriläinen J, Fernández M, Fiedler S, Bravin A, Karjalainen-Lindsberg ML, Virkkunen P, Elo EM, Tenhunen M, Suortti P, Thomlinson W: Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology. Eur J Radiol; 2005 Feb;53(2):226-37
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  • [Title] Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology.
  • Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique.
  • This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions.
  • [MeSH-major] Breast Neoplasms / radiography. Calcinosis / radiography. Collagen. Radiographic Image Enhancement / methods. X-Ray Diffraction / methods

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  • (PMID = 15664286.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 9007-34-5 / Collagen
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87. Cilotti A, Iacconi C, Marini C, Moretti M, Mazzotta D, Traino C, Naccarato AG, Piagneri V, Giaconi C, Bevilacqua G, Bartolozzi C: Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications. Radiol Med; 2007 Mar;112(2):272-86
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  • PURPOSE: The aim of this study was to evaluate the role of magnetic resonance imaging (MRI) in patients with microcalcifications classed as Breast Imaging Reporting and Data Systems (BI-RADS) 3-5.
  • Patients with a microhistological diagnosis of benign lesions underwent mammographic follow-up for at least 12 months.
  • RESULTS: Histology revealed 26 ductal in situ cancers (DCIS) and ductal microinvasive cancers (DCmic), three atypical ductal hyperplasias (ADH) and 26 benign conditions.
  • If we consider mammographic BI-RADS category 3 as benign and BI-RADS 4 and 5 as malignant, mammography had 77% sensitivity, 59% specificity, 63% positive predictive value (PPV), 74% negative predictive value (NPV) and 67.2% diagnostic accuracy.
  • If we consider MRI BI-RADS categories 1, 2 and 3 as benign and 4 and 5 as malignant, MRI had 73% sensitivity, 76% specificity, 73% PPV, 76% NPV and 74.5% diagnostic accuracy.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Calcinosis / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Magnetic Resonance Imaging. Mammography

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  • (PMID = 17361370.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media
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88. Michel SC, Löw R, Singer G, Otto R, Hohl M, Kubik RA: [Stereotactic Mammotome breast biopsy: routine clinical experience and correlation with BI-RADS--classification and histopathology]. Praxis (Bern 1994); 2007 Sep 26;96(39):1459-74
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  • [Title] [Stereotactic Mammotome breast biopsy: routine clinical experience and correlation with BI-RADS--classification and histopathology].
  • [Transliterated title] Die stereotaktische Mammotome-Brustbiopsie: Erfahrungen im klinischen Alltag und Korrelation der BI-RADS--Klassifikation mit der Histopathologie.
  • BACKGROUND: Stereotactic breast biopsy using the Mammotome system allows minimal invasive tissue sampling of suspicious lesions of the breast cancer, e.g. clustered microcalcifications BI-RADS type 3 and 4, and has widely replaced open surgical biopsies.
  • METHODS: One hundred thirty-five vacuum-assisted breast biopsies in 124 patients were evaluated.
  • Before biopsy, the mammograms were classified according to the Breast Imaging Reporting and Data System (BI-RADS).
  • Patients with benign diagnoses underwent mammographic follow-up.
  • Histopathology revealed 105 (78%) benign lesions.
  • Benign lesions were classified as BI-RADS 3 in 49 (36%) and as suspicious (BI-RADS 4) in 56 (41%).
  • Thirty lesions (22%) were malignant, of which 26 (87%) were classified BI-RADS 4 or 5.
  • Of the 53 BI-RADS 3 lesions, 4 (8%) were malignant.
  • The frequency of malignant histopathologic findings in BI-RADS 3 lesions was higher than expected, reflecting the difficulties in the mammographic differentiation of benign and malignant clustered microcalcifications.
  • [MeSH-major] Biopsy, Needle / instrumentation. Breast Neoplasms / pathology. Calcinosis / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Mammography / classification. Radiology Information Systems
  • [MeSH-minor] Adult. Aged. Breast / pathology. Breast Diseases / pathology. Female. Humans. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Statistics as Topic

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  • (PMID = 17966279.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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89. Kebudi A, Calişkan C, Yetkin G, Celebi S, Işgör A, Mesrur Halefoğlu A, Ezdeşir R, Akgün I: The role of pre-operative B mode ultrasound in the evaluation of the axillary lymph node metastases in the initial staging of breast carcinoma. Acta Chir Belg; 2005 Sep-Oct;105(5):511-4
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  • [Title] The role of pre-operative B mode ultrasound in the evaluation of the axillary lymph node metastases in the initial staging of breast carcinoma.
  • The lymph node status of a breast cancer is one of the main prognostic criterias.
  • Mammographic examination can give us an idea about breast cancer and axillary involvement.
  • 42 patients operated on for breast cancer between January 2000-January 2003 were included in this prospective study.
  • Hyperechogenic hilus was accepted as a benign finding.
  • The thickening of the cortex less than 50% of the thickening of the centric echogenic hilus was also accepted as a benign finding.
  • L/W ratio below 2 and parameters above 2 cm were accepted as malignant findings.
  • As a result, these lymph nodes were defined as benign in 19 patients (45.2%) and malignant in 23 patients (54.8%).
  • Axillary lymph node status was found as benign in 18 patients (42.9%) and malignant in 24 patients (57.1%) pathologically .
  • We think some better results may be obtained in the future and these developments may affect the surgeon's decisions concerning axillary dissection for breast cancer operations.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Lymphatic Metastasis / ultrasonography. Neoplasm Staging / methods

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  • (PMID = 16315836.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Belgium
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90. Golubicic I, Borojevic N, Pavlovic T: Risk factors for breast cancer: is ionizing radiation among them? J BUON; 2008 Oct-Dec;13(4):487-94
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  • [Title] Risk factors for breast cancer: is ionizing radiation among them?
  • It has been known that female breast tissue is highly sensitive to the carcinogenic effects of radiation, particularly when exposure takes place at younger age.
  • All women are exposed to low doses of radiation for several common reasons (kind of occupation, medical diagnostic procedures, residence background radiation) whose effects on breast cancer development cannot be documented, and thus it is believed that ionizing radiation is not primary or major risk factor leading to development of breast cancer.
  • The highest risk of radiation- induced breast cancer is evidenced in the sub-population of female patients who have undergone radiotherapy for either malignant or non-malignant diseases, including benign breast diseases in their childhood or young age.
  • [MeSH-major] Breast Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology

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  • (PMID = 19145669.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 27
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91. Campos LF, Silva AC, Barros AK: Independent component analysis and neural networks applied for classification of malignant, benign and normal tissue in digital mammography. Methods Inf Med; 2007;46(2):212-5
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  • [Title] Independent component analysis and neural networks applied for classification of malignant, benign and normal tissue in digital mammography.
  • OBJECTIVES: This paper proposes an efficient method for the discrimination and classification of mammograms with benign, malignant and normal tissues.
  • [MeSH-major] Breast / physiology. Breast Neoplasms / diagnosis. Image Processing, Computer-Assisted. Mammography. Neural Networks (Computer). Radiographic Image Enhancement. Signal Processing, Computer-Assisted

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  • (PMID = 17347758.001).
  • [ISSN] 0026-1270
  • [Journal-full-title] Methods of information in medicine
  • [ISO-abbreviation] Methods Inf Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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92. Itoh A, Ueno E, Tohno E, Kamma H, Takahashi H, Shiina T, Yamakawa M, Matsumura T: Breast disease: clinical application of US elastography for diagnosis. Radiology; 2006 May;239(2):341-50
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  • [Title] Breast disease: clinical application of US elastography for diagnosis.
  • PURPOSE: To evaluate the diagnostic performance of real-time freehand elastography by using the extended combined autocorrelation method (CAM) to differentiate benign from malignant breast lesions, with pathologic diagnosis as the reference standard.
  • Conventional ultrasonography (US) and real-time US elastography with CAM were performed in 111 women (mean age, 49.4 years; age range, 27-91 years) who had breast lesions (59 benign, 52 malignant).
  • RESULTS: For elasticity score, the mean +/- standard deviation was 4.2 +/- 0.9 for malignant lesions and 2.1 +/- 1.0 for benign lesions (P < .001).
  • CONCLUSION: For assessing breast lesions, US elastography with the proposed imaging classification, which was simple compared with that of the Breast Imaging Recording and Data System classification, had almost the same diagnostic performance as conventional US.
  • [MeSH-major] Breast Diseases / ultrasonography. Breast Neoplasms / ultrasonography


93. Lee KE, Kim HY, Park WS, Choe JH, Kwon MR, Oh SK, Youn YK: Postauricular and axillary approach endoscopic neck surgery: a new technique. World J Surg; 2009 Apr;33(4):767-72
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  • BACKGROUND: While the bilateral axillo-breast approach (BABA) to endoscopic neck surgery resolves various benign and malignant thyroid and parathyroid diseases with minimal adverse effects and excellent cosmetic outcomes, it involves circumareolar incisions.
  • Many patients, especially young female patients, are reluctant to have their breast involved.
  • Malignant lesions were treated with contralateral thyroid lobectomy.
  • [MeSH-minor] Adenoma / surgery. Adolescent. Adult. Axilla. Ear Auricle. Female. Humans. Male. Parathyroid Neoplasms / surgery. Thyroid Neoplasms / surgery. Young Adult

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  • (PMID = 19198933.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Ibarra JA: Papillary lesions of the breast. Breast J; 2006 May-Jun;12(3):237-51
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  • [Title] Papillary lesions of the breast.
  • Papillary lesions of the breast include a variety of benign, atypical, and malignant lesions whose hallmark is the formation of either papillary tufts composed only of epithelium, or true papillary structures with fibrovascular support and epithelium.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology

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  • (PMID = 16684322.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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95. Li C, Grobmyer SR, Chen L, Zhang Q, Fajardo LL, Jiang H: Multispectral diffuse optical tomography with absorption and scattering spectral constraints. Appl Opt; 2007 Dec 1;46(34):8229-36
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  • The initial clinical results indicate that the volume fraction of scattering particles in a malignant tumor is higher than that in a benign tumor.
  • [MeSH-minor] Body Water. Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Computer Simulation. Female. Hemoglobins / analysis. Humans. Linear Models. Middle Aged. Oxyhemoglobins / analysis. Particle Size. Phantoms, Imaging. Water / analysis

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  • (PMID = 18059661.001).
  • [ISSN] 0003-6935
  • [Journal-full-title] Applied optics
  • [ISO-abbreviation] Appl Opt
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA90533
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 059QF0KO0R / Water; 9008-02-0 / deoxyhemoglobin
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96. Li C, Grobmyer SR, Massol N, Liang X, Zhang Q, Chen L, Fajardo LL, Jiang H: Noninvasive in vivo tomographic optical imaging of cellular morphology in the breast: possible convergence of microscopic pathology and macroscopic radiology. Med Phys; 2008 Jun;35(6):2493-501
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  • [Title] Noninvasive in vivo tomographic optical imaging of cellular morphology in the breast: possible convergence of microscopic pathology and macroscopic radiology.
  • This article presents a pilot study of multispectral diffuse optical tomography for noninvasively imaging volume fraction and mean size of cellular scattering components in the breast.
  • Cellular morphology images for a total of 14 cases (four malignant breast and ten benign lesions) were obtained.
  • Analyzing the images based on the pathological findings of the cases studied, we found that light scattering in the breast was contributed from both the nucleus and organelles such as mitochondria and nucleolus.
  • Based on the image analysis of these 14 cases, we found that the differences in the mean size and volume fraction between the malignant and benign lesions are significant.
  • The contrast ratio of the average mean size and volume fraction between malignant and benign lesions were calculated to be 3.38 and 2.63.
  • These initial results suggest that cellular mean size and volume fraction may be two new criteria that could be used to differentiate malignant from benign lesions.
  • [MeSH-major] Breast / pathology. Mammography / methods. Tomography, Optical / methods
  • [MeSH-minor] Aged. Breast Neoplasms / diagnostic imaging. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / diagnostic imaging. Carcinoma, Ductal, Breast / pathology. Female. Humans. Image Processing, Computer-Assisted. Middle Aged. Spectrum Analysis

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  • (PMID = 18649482.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA090533; United States / NCI NIH HHS / CA / R01 CA90533
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2673633
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97. Tomimaru Y, Komoike Y, Egawa C, Motomura K, Inaji H, Kataoka TR, Koyama H: A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma. Breast Cancer; 2005;12(4):322-6
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  • [Title] A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma.
  • A 43-year-old woman was referred to our institute because of a left breast mass which was diagnosed as FA clinically.
  • During the follow-up, the mass gradually enlarged and excisional biopsy was performed to rule out malignant lesion.
  • On histological examination, the tumor consisted of three different components; a lesion diagnosed as FA, another lesion as benign PT, and the other lesion as borderline PT.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis

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  • (PMID = 16286914.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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98. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N: Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg; 2009 Oct;198(4):566-74
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  • [Title] Rapid noninvasive optical imaging of tissue composition in breast tumor margins.
  • BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can require re-excision.
  • Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors.
  • Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002).
  • CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.

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  • (PMID = 19800470.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024128; United States / NCRR NIH HHS / RR / UL1 RR024128-01; United States / NCRR NIH HHS / RR / 1UL1 RR024128-01
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS137679; NLM/ PMC2764289
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99. Kanae Y, Endoh D, Yokota H, Taniyama H, Hayashi M: Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs. Am J Vet Res; 2006 Jan;67(1):127-33
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  • [Title] Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs.
  • OBJECTIVE: To determine whether changes in expression level of the phosphatase and tensin homolog deleted on the chromosome 10 (PTEN) gene are associated with malignant transformation in mammary gland tumors in dogs.
  • SAMPLE POPULATION: Specimens of 5 benign and 8 malignant mammary gland tumors and 2 unaffected mammary glands from dogs.
  • RESULTS: Compared with findings in clinically normal samples, amounts of PTEN mRNA were increased 2- to 4-fold in 4 of the 5 benign mammary gland tumor samples.
  • In contrast, PTEN expression was remarkably low in 4 of the 8 malignant tumor samples (approx 12% to 37% of the level in unaffected mammary gland specimens).
  • Gene amplification via the RT-PCR method with total RNA prepared from malignant tumor samples as a template yielded 3 bands that were smaller than the full-length ORF product of PTEN gene; in 2 of those 3 RT-PCR products, exons 6 and 7 or exons 3 to 8 were absent.
  • [MeSH-major] Breast Neoplasms / veterinary. Dog Diseases / metabolism. Gene Expression Regulation, Neoplastic. PTEN Phosphohydrolase / metabolism

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  • (PMID = 16426222.001).
  • [ISSN] 0002-9645
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.1.3.67 / PTEN Phosphohydrolase
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100. Benarroch-Gampel J, Riall TS: Extrapancreatic malignancies and intraductal papillary mucinous neoplasms of the pancreas. World J Gastrointest Surg; 2010 Oct 27;2(10):363-7
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  • [Title] Extrapancreatic malignancies and intraductal papillary mucinous neoplasms of the pancreas.
  • Over the last two decades multiple studies have demonstrated an increased incidence of additional malignancies in patients with intraductal papillary mucinous neoplasms (IPMNs).
  • The gastrointestinal tract is most commonly involved in secondary malignancies, with benign colon polyps and colon cancer commonly seen in western countries and gastric cancer commonly seen in Asian countries.
  • Other extrapancreatic malignancies associated with IPMNs include benign and malignant esophageal neoplasms, gastrointestinal stromal tumors, carcinoid tumors, hepatobiliary cancers, breast cancers, prostate cancers, and lung cancers.
  • Routine screening studies (breast and prostate) should be carried out as currently recommended for patient's age both before and after the diagnosis of IPMN.

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  • (PMID = 21160845.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999205
  • [Keywords] NOTNLM ; Intraductal papillary mucinous neoplasm / Invasive / Malignant potential / Non-invasive / Secondary malignancy
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