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1
benign anal tumor 2005:2010[pubdate] *count=100
170 results
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Items 1 to 100 of about 170
1.
Cuschieri K, Wentzensen N:
Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia.
Cancer Epidemiol Biomarkers Prev
; 2008 Oct;17(10):2536-45
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[Title]
Human papillomavirus mRNA and p16 detection as biomarkers for the improved
diagnosis of
cervical
neoplasia
.
Human papillomavirus (HPV) infection of the genital tract is very common and normally follows a
benign
clinical course; however, in an unfortunate minority of infected individuals, it can cause disease that sometimes leads to cancer.
[MeSH-major]
Biomarkers,
Tumor
/ analysis.
Neoplasm
Proteins / genetics. Papillomaviridae / isolation & purification. Papillomavirus Infections /
diagnosis
. RNA, Messenger / analysis. Uterine Cervical Neoplasms /
diagnosis
[MeSH-minor]
Female. Humans. Mass Screening / methods. Precancerous Conditions /
diagnosis
. Precancerous Conditions / genetics. Precancerous Conditions / virology
MedlinePlus Health Information.
consumer health - Cervical Cancer
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
The Lens.
Cited by Patents in
.
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(PMID = 18842994.001).
[ISSN]
1055-9965
[Journal-full-title]
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
[ISO-abbreviation]
Cancer Epidemiol. Biomarkers Prev.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / ZIA CP010124-14
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / RNA, Messenger
[Number-of-references]
89
[Other-IDs]
NLM/ NIHMS212843; NLM/ PMC2900792
2.
Hsu A, Bray TM, Helferich WG, Doerge DR, Ho E:
Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells.
Exp Biol Med (Maywood)
; 2010 Jan;235(1):90-7
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Benign
prostate hyperplasia (BPH-1), LnCap and PC3 cells were treated with varying concentrations of soy extract, genistein or daidzein and analyzed for cell cycle alterations and induction of apoptosis.
No significant changes in cell cycle arrest or apoptosis were observed in non-cancerous BPH-1 cells treated with soy extract, suggesting that the effects of soy extract may be
tumor
cell specific.
[MeSH-minor]
Anticarcinogenic Agents / pharmacology. Caspases / metabolism. Cell Cycle / drug effects. Cell Line,
Tumor
. Dietary Supplements. Enzyme Activation / drug effects. Humans. Male. NF-kappa B / metabolism. Phytoestrogens / pharmacology. Plant Extracts / pharmacology. bcl-2-Associated X Protein / metabolism
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(PMID = 20404023.001).
[ISSN]
1535-3699
[Journal-full-title]
Experimental biology and medicine (Maywood, N.J.)
[ISO-abbreviation]
Exp. Biol. Med. (Maywood)
[Language]
eng
[Grant]
United States / NIEHS NIH HHS / ES / P30 ES00210; United States / NCI NIH HHS / CA / CA107693; United States / NCI NIH HHS / CA / R01 CA107693; United States / NIA NIH HHS / AG / P01 AG024387; United States / NIA NIH HHS / AG / P01-AG024387; United States / NCCIH NIH HHS / AT / P50 AT006268; United States / NIEHS NIH HHS / ES / P30 ES000210
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Anticarcinogenic Agents; 0 / BAX protein, human; 0 / Isoflavones; 0 / NF-kappa B; 0 / Phytoestrogens; 0 / Plant Extracts; 0 / bcl-2-Associated X Protein; 1POG3SCN5T / genistin; 6287WC5J2L / daidzein; EC 3.4.22.- / Caspases
[Other-IDs]
NLM/ NIHMS617415; NLM/ PMC4125131
3.
Wietfeldt ED, Thiele J:
Malignancies of the anal margin and perianal skin.
Clin Colon Rectal Surg
; 2009 May;22(2):127-35
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[Title]
Malignancies of the
anal
margin and perianal skin.
Malignancies of the
anal
margin and perianal skin are relatively uncommon lesions, comprising 3 to 4% of all anorectal malignancies.
Buschke-Lowenstein
tumor
, or giant condyloma acuminatum, is not always included because this lesion is technically
benign
, although it displays aggressive local invasive behavior that makes it difficult to manage.
Proper
diagnosis
requires a high index of suspicion on the part of the surgeon.
Innocent local irritations will resolve in a short time with appropriate therapy; those that persist must be biopsied for tissue
diagnosis
.
Invasion and metastasis are relatively rare in this group of neoplasms; perianal Paget's disease has the highest risk of associated underlying
neoplasm
.
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]
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[ISSN]
1530-9681
[Journal-full-title]
Clinics in colon and rectal surgery
[ISO-abbreviation]
Clin Colon Rectal Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2780245
[Keywords]
NOTNLM ; Anal margin cancer / diagnosis / local excision / radiation therapy / treatment options
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4.
Xi Z, LinLin M, Ye T:
Human epididymis protein 4 is a biomarker for transitional cell carcinoma in the urinary system.
J Clin Lab Anal
; 2009;23(6):357-61
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METHODS: 102 patients with TCC, 60 with
benign
urinary diseases, and 60 healthy controls were included in this study.
RESULTS: The HE4 level was significantly increased in patients with TCC compared to patients with
benign
urinary diseases patients (P<0.01) and healthy controls (P<0.01), and the level of HE4 in patients with superficial TCC (Tis Ta T1) was significantly higher than that of the
benign
urogenital group (P<0.05)and healthy controls (P<0.05).
There was no difference between HE4 levels based on
tumor
recurrence, clinical TNM stage, lymph node metastasis, or pathological stage (P>0.05).
The HE4 level was also different between patients with a single
tumor
versus patients with multiple tumors.
CONCLUSIONS: HE4 may be a screening tool for early
diagnosis of
TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system.
[MeSH-major]
Biomarkers,
Tumor
/ blood. Carcinoma, Transitional Cell / blood. Epididymal Secretory Proteins / metabolism. Urologic Neoplasms / blood
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(PMID = 19927341.001).
[ISSN]
1098-2825
[Journal-full-title]
Journal of clinical laboratory analysis
[ISO-abbreviation]
J. Clin. Lab. Anal.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / DEFB126 protein, human; 0 / Epididymal Secretory Proteins; 0 / beta-Defensins
5.
Miragliotta V, Ipiña Z, Lefebvre-Lavoie J, Lussier JG, Theoret CL:
Equine CTNNB1 and PECAM1 nucleotide structure and expression analyses in an experimental model of normal and pathological wound repair.
BMC Physiol
; 2008;8:1
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Specifically, wounds on horse limbs often develop exuberant granulation tissue which behaves clinically like a
benign tumor
and resembles the human keloid in that the evolving scar is trapped in the proliferative phase of repair, leading to fibrosis.
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[ISSN]
1472-6793
[Journal-full-title]
BMC physiology
[ISO-abbreviation]
BMC Physiol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antigens, CD31; 0 / beta Catenin
[Other-IDs]
NLM/ PMC2268708
6.
McNeill RE, Miller N, Kerin MJ:
Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer.
BMC Mol Biol
; 2007;8:107
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RESULTS: The expression and validity of candidate ECs (GAPDH, TFRC, ABL, PPIA, HPRT1, RPLP0, B2M, GUSB, MRPL19, PUM1 and PSMC4) was determined in 6
benign
and 21 malignant primary breast cancer tissues.
ESR1 expression was appreciably higher in malignant compared to
benign
tissues and there was a significant effect of EC on the magnitude of the error associated with the relative quantity of ESR1.
[MeSH-minor]
Biomarkers,
Tumor
/ genetics. Estrogen Receptor alpha / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Reproducibility of Results
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[ISSN]
1471-2199
[Journal-full-title]
BMC molecular biology
[ISO-abbreviation]
BMC Mol. Biol.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Estrogen Receptor alpha; 0 / estrogen receptor alpha, human
[Other-IDs]
NLM/ PMC2211316
7.
Stanley JD, Bell C, Hinkle N, Moore RA, Burns RP:
The Ferguson Operating Anoscope as a minimally invasive option for the treatment of rectal tumors.
Am Surg
; 2010 Aug;76(8):850-6
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This retrospective case series evaluates the effectiveness of FOA for the excision of selected
benign
and malignant rectal tumors.
In the 97 patients evaluated, 99 FOA transanal excisions were performed for 39 adenocarcinomas, 55
benign
tumors, and five carcinoid tumors.
The tumors were 0.5 to 13.5 cm in diameter and located an average of 6.9 cm (range, 1 to 15 cm) from the
anal
verge.
In early follow up of adenomas and favorable T1 carcinomas, FOA transanal excision has similar application, morbidity, and recurrence rates as reported for transanal endoscopic microsurgery for rectal tumors within 15 cm from the
anal
verge.
[MeSH-minor]
Adenocarcinoma / surgery. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoid
Tumor
/ surgery. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Retrospective Studies
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(PMID = 20726416.001).
[ISSN]
0003-1348
[Journal-full-title]
The American surgeon
[ISO-abbreviation]
Am Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
8.
Martino P, Martino D, Palazzo S, Altomare DF, Garofalo L, Battaglia M, Selvaggi FP:
Incidental discovery of ano-rectal disease during transrectal ultrasound performed for prostatic disease.
Arch Ital Urol Androl
; 2005 Mar;77(1):37-9
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[Title]
Incidental discovery
of ano
-rectal disease during transrectal ultrasound performed for prostatic disease.
In 132 cases (27%) it was shown to be a false positive, mainly due to imperfect cleansing of the
anal
canal; in 284 cases (58%)
benign
disease was demonstrated (hemorrhoids in 192 patients, abscesses in 21, perianal fistulas in 18, inflamed lymph nodes in 27, polyps in 16).
In 34 patients (7%) a malignant
tumor
was found (infiltration of the anterior rectal wall by a prostatic adenocarcinoma in 13, and a primitive adenocarcinoma of rectal origin in the remaining 21).
It can be concluded that transrectal US does not permit a certain
diagnosis of
the nature of rectal disease, but does raise a diagnostic suspicion that can orient the surgeon to schedule more invasive diagnostic investigations.
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(PMID = 15906788.001).
[ISSN]
1124-3562
[Journal-full-title]
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
[ISO-abbreviation]
Arch Ital Urol Androl
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
Italy
9.
Schulte T, Kahlke V:
[Mass of the pelvis minor--the coloproctological point of view].
Ther Umsch
; 2007 Jul;64(7):389-94
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It contains the pelvic organs like the inner genital organs of women, the urinary bladder the rectum and parts of the
anus
.
The rectum is the origin of
benign
and malign tumors.
Most frequently you find under these tumors the
benign
adenoma and hamartoma and the malign like the rectal and
anal
cancer.
The further diagnostic work up and following therapy relates to the histology and the anatomical location of the
tumor
.
[MeSH-major]
Anus
Neoplasms. Pelvic Neoplasms. Rectal Neoplasms
[MeSH-minor]
Adult. Colonoscopy. Combined Modality Therapy.
Diagnosis
, Differential. Endosonography. Humans. Middle Aged.
Neoplasm
Staging. Postoperative Care. Proctoscopy. Rectum / pathology. Tomography, X-Ray Computed
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(PMID = 17948756.001).
[ISSN]
0040-5930
[Journal-full-title]
Therapeutische Umschau. Revue thérapeutique
[ISO-abbreviation]
Ther Umsch
[Language]
ger
[Publication-type]
Comparative Study; English Abstract; Journal Article
[Publication-country]
Switzerland
10.
Wang P, Bista RK, Khalbuss WE, Qiu W, Uttam S, Staton K, Zhang L, Brentnall TA, Brand RE, Liu Y:
Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy.
J Biomed Opt
; 2010 Nov-Dec;15(6):066028
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[Title]
Nanoscale nuclear architecture for cancer
diagnosis
beyond pathology via spatial-domain low-coherence quantitative phase microscopy.
Definitive
diagnosis of
malignancy is often challenging due to limited availability of human cell or tissue samples and morphological similarity with certain
benign
conditions.
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[
10629118.001
]
(PMID = 21198202.001).
[ISSN]
1560-2281
[Journal-full-title]
Journal of biomedical optics
[ISO-abbreviation]
J Biomed Opt
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R21 CA152935-01; United States / NCI NIH HHS / CA / R21CA152935; United States / NCI NIH HHS / CA / R21 CA138370; United States / NCI NIH HHS / CA / R21 CA138370-01; United States / NCI NIH HHS / CA / R21 CA152935; United States / NCI NIH HHS / CA / CA138370-02; United States / NCI NIH HHS / CA / R21CA138370; United States / NCI NIH HHS / CA / CA152935-01; United States / NCI NIH HHS / CA / R21 CA138370-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Other-IDs]
NLM/ PMC3025597
11.
Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM:
Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
Anal Chem
; 2010 Apr 1;82(7):2621-5
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Often considered
benign
, meningiomas represent 32% of intracranial tumors with three grades of malignancy defined by the World Health Organization (WHO) histology based classification.
A preliminary classifier based on the support vector machine showed the ability to distinguish meningioma image spectra from the nontumor brain and from gliomas, a different type of brain
tumor
, and to enable class imaging of surgical tissue.
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12640680.001
]
(PMID = 20196536.001).
[ISSN]
1520-6882
[Journal-full-title]
Analytical chemistry
[ISO-abbreviation]
Anal. Chem.
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / U41 RR019703; United States / NIBIB NIH HHS / EB / U54 EB005149-030003; United States / NIBIB NIH HHS / EB / U54 EB005149; United States / NCRR NIH HHS / RR / P41 RR-13218; United States / NCRR NIH HHS / RR / RR013218-108435; United States / NCRR NIH HHS / RR / P41 RR013218-108435; United States / NCRR NIH HHS / RR / P41 RR013218; United States / NIBIB NIH HHS / EB / EB005149-030003
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Other-IDs]
NLM/ NIHMS184740; NLM/ PMC2852177
12.
Driemel O, Dahse R, Berndt A, Pistner H, Hakim SG, Zardi L, Reichert TE, Kosmehl H:
High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies.
Clin Oral Investig
; 2007 Mar;11(1):93-9
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Tumour
-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content.
Analysis using antibody BC2 indicates that especially the high-molecular tenascin-C (hm tn-C) variants are typically
tumour
-associated, while distribution in normal tissue is restrictive.
Conventional cytology produced four false-positives when identifying atypical cells in brush biopsies of inflammatory/
benign
hyperproliferative mucosa (specificity 96%), while 10 in 52 carcinomas and three of eight recurrences were not identified (sensitivity 78%).
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Tenascin / analysis
[MeSH-minor]
Epithelial Cells / pathology. Humans. Immunoenzyme Techniques. Mouth Mucosa / pathology.
Neoplasm
Invasiveness / pathology. Prospective Studies. Sensitivity and Specificity
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Mund Kiefer Gesichtschir. 2004 Jul;8(4):229-36
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(PMID = 17111122.001).
[ISSN]
1432-6981
[Journal-full-title]
Clinical oral investigations
[ISO-abbreviation]
Clin Oral Investig
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Tenascin
13.
Nagy A, Kovacs T, Lóderer Z:
Experiences with PPH gun stapled ileo or coloanal anastomoses after ultralow rectal resections and proctocolectomies with J pouch reconstructions.
Acta Chir Iugosl
; 2006;53(2):61-3
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On 47 totalcolectomised FAP and UC patients and 9 low rectal
benign
or clinically T1 or T2N0 rectal
tumor
resection there was only 5 radiologically proven anastomotic leakadge without serious septic complications.
The
anal
sphincter function after 6 month of the ileoanal anastomosis remained good in 33/39 and acceptable in 6 cases, if the sphincter function was intact praeoperatively.
After the ultra low rectal resections all patients kept the normal
anal
shpincter function.
[MeSH-major]
Anal
Canal / surgery. Colon / surgery. Ileum / surgery. Proctocolectomy, Restorative. Rectum / surgery. Surgical Stapling
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(PMID = 17139887.001).
[ISSN]
0354-950X
[Journal-full-title]
Acta chirurgica Iugoslavica
[ISO-abbreviation]
Acta Chir Iugosl
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Serbia and Montenegro
14.
Tsao KC, Hong JH, Wu TL, Chang PY, Sun CF, Wu JT:
Elevation of CA 19-9 and chromogranin A, in addition to CA 125, are detectable in benign tumors in leiomyomas and endometriosis.
J Clin Lab Anal
; 2007;21(3):193-6
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[Title]
Elevation of CA 19-9 and chromogranin A, in addition to CA 125, are detectable in
benign
tumors in leiomyomas and endometriosis.
As the best-known
tumor
marker for ovarian carcinoma, CA 125 has also been commonly used to monitor patients with common
benign
gynecologic diseases such as endometriosis and leiomyoma.
Both of these
benign
tumors are known to be at risk of developing into cancer.
During the screening of an asymptomatic population with multiple
tumor
markers, including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), CA 125, CA 19-9, CA 15-3, chromogranin A (CgA), and squamous cell carcinoma antigen (SCC), we have detected elevated
tumor
markers in 142 individuals; 19 of them were diagnosed with endometriosis or leiomyoma or both.
In addition to the detection of elevation of CA 125 in these
benign
tumors, elevated CA 19-9 or CgA was also found in these patients with endometriosis or leiomyoma.
It appears that instead of monitoring only CA 125, as is traditionally done, multiple
tumor
markers, including CA 19-9, CgA, and CA 125, should be measured simultaneously in women with clinical disorders associated with the ovary or uterus in order to detect gynecologic
benign
tumors and in order to prevent further development of cancer.
[MeSH-major]
Biomarkers,
Tumor
/ blood. CA-125 Antigen / blood. CA-19-9 Antigen / blood. Chromogranin A / blood. Endometrial Neoplasms / blood. Endometriosis / blood. Leiomyoma / blood
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NCI CPTC Antibody Characterization Program.
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NCI CPTC Antibody Characterization Program.
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[Copyright]
(c) 2007 Wiley-Liss, Inc.
(PMID = 17506483.001).
[ISSN]
0887-8013
[Journal-full-title]
Journal of clinical laboratory analysis
[ISO-abbreviation]
J. Clin. Lab. Anal.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Chromogranin A
15.
Branchini G, Schneider L, Cericatto R, Capp E, Brum IS:
Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas.
Endocrine
; 2009 Jun;35(3):459-66
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Fibroadenomas are the most common
benign
breast tumors, occurring mainly in young women.
Their responses to the hormonal environment are similar to those of normal breast tissue, which suggests that steroid receptors may play a role in
tumor
development.
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[ISSN]
1355-008X
[Journal-full-title]
Endocrine
[ISO-abbreviation]
Endocrine
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Estrogen Receptor alpha; 0 / Receptors, Progesterone; 0 / progesterone receptor A; 0 / progesterone receptor B
16.
Celis JE, Gromova I, Cabezón T, Gromov P, Shen T, Timmermans-Wielenga V, Rank F, Moreira JM:
Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease.
Mol Oncol
; 2007 Dec;1(3):321-49
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Recently, we presented evidence--based on the analysis of
benign
hyperproliferative lesions of the breast--for the presence of cells that express the stem cell marker cytokeratin (CK) 15 in combination with CK19, a protein widely expressed by mammary epithelial cells.
The remaining
tumor
was mainly composed of cells expressing both CK15 and CK19 (CK15+/CK19+), but it also contained invasive areas with cells expressing only one of these makers (CK15+/CK19- and CK15-/CK19+ cells).
To address the relationship between putative luminal progenitor/amplified CK15+ cells and malignant disease, and to determine whether cells/lesions lose expression of CK15 as a result
of tumour
initiation and/or progression, we searched among our sample set for carcinomas in which invasive
tumor
areas co-existed with non-malignant cells and hyperproliferative and known pre-malignant lesions.
Only one such
tumour
was found (T71), a CK15-/CK19+/p53+ carcinoma that contained p53 negative non-malignant epithelial cells exhibiting a variety of, CK15/CK19 cellular phenotypes (CK15+/CK19+; CK15+/CK19-; CK15-/CK19+; CK15-/CK19-), often associated with simple columnar cells.
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Carcinoma / genetics. Carcinoma / metabolism. Carcinoma / pathology. Female. Fluorescent Antibody Technique, Direct. Humans. Immunohistochemistry. Middle Aged.
Neoplasm
Invasiveness
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[ISSN]
1878-0261
[Journal-full-title]
Molecular oncology
[ISO-abbreviation]
Mol Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Keratin-15
17.
Woenckhaus M, Grepmeier U, Werner B, Schulz C, Rockmann F, Wild PJ, Röckelein G, Blaszyk H, Schuierer M, Hofstaedter F, Hartmann A, Dietmaier W:
Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology.
J Mol Diagn
; 2005 Oct;7(4):517-24
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A common diagnostic problem lies in distinguishing malignant from
benign
pleural effusions using routine cytological evaluation.
We studied pleural fluid samples obtained from 14 patients with histologically confirmed malignancy and from 6 patients with
benign
pleural effusions using 12 microsatellite markers from 8 different chromosomal regions.
Microsatellite analyses of pleural fluid supernatants showed genetic alterations in
tumor
patients only.
[MeSH-minor]
Aged. Aged, 80 and over. Female. Genetic Markers / genetics. Humans. Loss of Heterozygosity / genetics. Male. Middle Aged. Neoplasms /
diagnosis
. Neoplasms / genetics. Neoplasms / pathology. Sensitivity and Specificity
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[ISSN]
1525-1578
[Journal-full-title]
The Journal of molecular diagnostics : JMD
[ISO-abbreviation]
J Mol Diagn
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Genetic Markers
[Other-IDs]
NLM/ PMC1888495
18.
Bistulfi G, Vandette E, Matsui S, Smiraglia DJ:
Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells.
BMC Biol
; 2010 Jan 21;8:6
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RESULTS: We studied the consequences of long-term, mild folate depletion in a model comprised of three syngenic cell lines derived from the transgenic adenoma of the mouse prostate (TRAMP) model, recapitulating different stages of prostate cancer;
benign
, transformed and metastatic.
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[ISSN]
1741-7007
[Journal-full-title]
BMC biology
[ISO-abbreviation]
BMC Biol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P30 CA016056; United States / NCI NIH HHS / CA / R21 CA131646; United States / NCI NIH HHS / CA / CA016056; United States / NCI NIH HHS / CA / R21 CA121216
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
6R795CQT4H / 5-Methylcytosine
[Other-IDs]
NLM/ PMC2845099
19.
Bereman MS, Williams TI, Muddiman DC:
Development of a nanoLC LTQ orbitrap mass spectrometric method for profiling glycans derived from plasma from healthy, benign tumor control, and epithelial ovarian cancer patients.
Anal Chem
; 2009 Feb 1;81(3):1130-6
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[Title]
Development of a nanoLC LTQ orbitrap mass spectrometric method for profiling glycans derived from plasma from healthy,
benign tumor
control, and epithelial ovarian cancer patients.
In addition, data are compared among samples derived from 10 healthy controls, 10 controls with a differential
diagnosis of
benign
gynecologic tumors, and 10 diseased epithelial ovarian cancer patients (EOC).
However, these same glycans provided a significantly less diagnostic value when used to differentiate EOC from
benign tumor
control samples with an area under the curve of 0.73.
[MeSH-major]
Biomarkers,
Tumor
/ blood. Carcinoma /
diagnosis
. Chromatography, Liquid / methods. Glycoproteins / blood. Ovarian Neoplasms /
diagnosis
. Polysaccharides / blood. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
[MeSH-minor]
Female. Genital Neoplasms, Female / chemistry. Genital Neoplasms, Female /
diagnosis
. Humans. Hydrophobic and Hydrophilic Interactions. Lectins / blood. Lectins / chemistry. Male. ROC Curve
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[ISSN]
1520-6882
[Journal-full-title]
Analytical chemistry
[ISO-abbreviation]
Anal. Chem.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R33 CA105295; United States / NCI NIH HHS / CA / R33 CA105295
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Lectins; 0 / Polysaccharides; 0 / fucose-binding lectin
[Other-IDs]
NLM/ NIHMS496567; NLM/ PMC3739471
20.
Zon G, Barker MA, Kaur P, Groshen S, Jones LW, Imam SA, Boyd VL:
Formamide as a denaturant for bisulfite conversion of genomic DNA: Bisulfite sequencing of the GSTPi and RARbeta2 genes of 43 formalin-fixed paraffin-embedded prostate cancer specimens.
Anal Biochem
; 2009 Sep 15;392(2):117-25
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Detection of methylated GSTPi and RARbeta2 genes was significantly associated with primary prostate cancer as compared with the
benign
prostate (Fisher's exact test, P < 0.001).
[MeSH-major]
DNA,
Neoplasm
/ chemistry. Formamides / pharmacology. Genome, Human. Glutathione S-Transferase pi / genetics. Prostatic Neoplasms / genetics. Receptors, Retinoic Acid / genetics. Sequence Analysis, DNA / methods
[MeSH-minor]
Base Sequence. Biomarkers,
Tumor
/ genetics. Biopsy. DNA Methylation. Formaldehyde. Humans. Male. Molecular Sequence Data. Nucleic Acid Denaturation / drug effects. Paraffin Embedding. Sulfites
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Hazardous Substances Data Bank.
FORMALDEHYDE
.
Hazardous Substances Data Bank.
FORMAMIDE
.
NCI CPTAC Assay Portal.
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.
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(PMID = 19505431.001).
[ISSN]
1096-0309
[Journal-full-title]
Analytical biochemistry
[ISO-abbreviation]
Anal. Biochem.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Formamides; 0 / Receptors, Retinoic Acid; 0 / Sulfites; 0 / retinoic acid receptor beta; 1HG84L3525 / Formaldehyde; 4781T907ZS / formamide; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi
21.
Bese T, Barbaros M, Baykara E, Guralp O, Cengiz S, Demirkiran F, Sanioglu C, Arvas M:
Comparison of total plasma lysophosphatidic acid and serum CA-125 as a tumor marker in the diagnosis and follow-up of patients with epithelial ovarian cancer.
J Gynecol Oncol
; 2010 Dec 30;21(4):248-54
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[Title]
Comparison of total plasma lysophosphatidic acid and serum CA-125 as a
tumor
marker in
the diagnosis
and follow-up of patients with epithelial ovarian cancer.
OBJECTIVE: To evaluate the role of lysophosphatidic acid (LPA) as a
tumor
marker in
diagnosis
and follow-up of patients with epithelial ovarian cancer.
METHODS: Eighty-seven epithelial ovarian cancer patients, 74
benign
ovarian
tumor
patients, and 50 healthy women were enrolled in the study.
RESULTS: Preoperative total plasma LPA and serum CA-125 levels were significantly higher in patients with epithelial ovarian cancer compared to patients with
benign
ovarian tumors and healthy women.
CONCLUSION: LPA is a better biomarker for
diagnosis of
epithelial ovarian cancer compared to CA-125.
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[ISSN]
2005-0399
[Journal-full-title]
Journal of gynecologic oncology
[ISO-abbreviation]
J Gynecol Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Korea (South)
[Other-IDs]
NLM/ PMC3026304
[Keywords]
NOTNLM ; CA-125 / Chemotherapy / Epithelial ovarian cancer / Follow-up / Lysophosphatidic acid / Tumor marker
22.
Yili Z, Xiaoyan H, Hongwen D, Yun Z, Xin C, Peng W, Youmin G:
The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma.
BMC Cancer
; 2009;9:18
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BACKGROUND: To define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from
benign
lesions, and to evaluate the ADC change of peri-
tumor
tissue in breast carcinoma by echo planar-diffusion weighted imaging (EPI-DWI).
The ADC values were compared between malignant and
benign
lesions.
The ADC values of malignant lesion and layered peri-
tumor
tissues (from innermost layer 1 to outermost layer 4 with 5 mm every layer) in different directions were compared and the ADC values among different layers were compared.
RESULTS: The ADC value of 35 malignant lesions was statistically lower than that of 22
benign
lesions (P < 0.05).
The ADC value of malignant lesions was statistically lower than that of peri-
tumor
tissues in different directions (P < 0.05).
For peri-
tumor
tissues, the ADC values increased gradually from layer 1 to layer 4 and there was a significant difference between the ADC values of layer 1 and layer 2 (P < 0.05); while from layer 2 outwards, there was no statistical difference among different layers.
CONCLUSION: ADC value was a sensitive and specific parameter that could help to differentiate
benign
and malignant breast lesions.
[MeSH-major]
Breast Diseases /
diagnosis
. Breast Neoplasms /
diagnosis
. Echo-Planar Imaging / methods
[MeSH-minor]
Adult. Aged. Breast / pathology. Carcinoma, Ductal, Breast /
diagnosis
. Carcinoma, Ductal, Breast / pathology.
Diagnosis
, Differential. Female. Fibroadenoma /
diagnosis
. Fibroadenoma / pathology. Humans. Hyperplasia. Middle Aged
MedlinePlus Health Information.
consumer health - Breast Cancer
.
MedlinePlus Health Information.
consumer health - Breast Diseases
.
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Breast Cancer Res Treat. 2005 Dec;94(3):195-8
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(PMID = 19144163.001).
[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2633008
23.
Ciordia S, de Los Ríos V, Albar JP:
Contributions of advanced proteomics technologies to cancer diagnosis.
Clin Transl Oncol
; 2006 Aug;8(8):566-80
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[Title]
Contributions of advanced proteomics technologies to cancer
diagnosis
.
This discipline incorporates technologies that can be applied to complex biosystems such as serum and tissue in order to characterize the content of, and changes in, the proteome induced by physiological changes,
benign
or pathologic.
These tools include 2-
DE
, 2D-DIGE, ICAT, protein arrays, MudPIT and mass spectrometries including SELDI-TOF.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Neoplasms /
diagnosis
. Neoplasms / genetics. Proteome / analysis. Proteomics / trends
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[ISSN]
1699-048X
[Journal-full-title]
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
[ISO-abbreviation]
Clin Transl Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Italy
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Proteome
[Number-of-references]
108
24.
Campioni S, Mannini B, Zampagni M, Pensalfini A, Parrini C, Evangelisti E, Relini A, Stefani M, Dobson CM, Cecchi C, Chiti F:
A causative link between the structure of aberrant protein oligomers and their toxicity.
Nat Chem Biol
; 2010 Feb;6(2):140-7
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We describe two types of oligomers formed by the HypF-N protein that are morphologically and tinctorially similar, as detected with atomic force microscopy and thioflavin T assays, though one is
benign
when added to cell cultures whereas the other is toxic.
[MeSH-minor]
Cell Line,
Tumor
. Cell Membrane / metabolism. Cell Survival. Humans. Hydrophobic and Hydrophilic Interactions. Microscopy, Atomic Force. Protein Binding. Protein Conformation
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(PMID = 20081829.001).
[ISSN]
1552-4469
[Journal-full-title]
Nature chemical biology
[ISO-abbreviation]
Nat. Chem. Biol.
[Language]
eng
[Databank-accession-numbers]
PDB/ 1GXU
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Escherichia coli Proteins; EC 2.1.3.- / Carboxyl and Carbamoyl Transferases; EC 2.1.3.- / hypF protein, E coli
25.
Almsherqi Z, Hyde S, Ramachandran M, Deng Y:
Cubic membranes: a structure-based design for DNA uptake.
J R Soc Interface
; 2008 Sep 6;5(26):1023-9
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Cubic membranes thus may offer a new, potentially
benign
medium for gene transfection.
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[ISSN]
1742-5689
[Journal-full-title]
Journal of the Royal Society, Interface
[ISO-abbreviation]
J R Soc Interface
[Language]
ENG
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Phosphorothioate Oligonucleotides; 9007-49-2 / DNA
[Other-IDs]
NLM/ PMC2607430
26.
Sekine Y, Demosky SJ, Stonik JA, Furuya Y, Koike H, Suzuki K, Remaley AT:
High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism.
Mol Cancer Res
; 2010 Sep;8(9):1284-94
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In human prostate biopsy samples, ABCA1 mRNA expression was ∼2-fold higher in the androgen deprivation therapy group than in subjects with
benign
prostatic hyperplasia or pretreatment prostate cancer groups.
[MeSH-minor]
ATP Binding Cassette Transporter 1. Androgens / metabolism. Cell Line,
Tumor
. Cell Proliferation / drug effects. Cholesterol / metabolism. Enzyme Activation / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Expression Regulation, Neoplastic / drug effects. Humans. Intracellular Space / drug effects. Intracellular Space / metabolism. Male. Proto-Oncogene Proteins c-akt / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Small Interfering / metabolism. Simvastatin / pharmacology
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[Copyright]
© 2010 AACR.
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[ISSN]
1557-3125
[Journal-full-title]
Molecular cancer research : MCR
[ISO-abbreviation]
Mol. Cancer Res.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / NIH0013975756; United States / PHS HHS / / NIH0013975756; United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
0 / ABCA1 protein, human; 0 / ATP Binding Cassette Transporter 1; 0 / ATP-Binding Cassette Transporters; 0 / Androgens; 0 / Lipoproteins, HDL; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 97C5T2UQ7J / Cholesterol; AGG2FN16EV / Simvastatin; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
[Other-IDs]
NLM/ NIHMS222887; NLM/ PMC2941551
27.
van de Luijtgaarden AC, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT:
Metastatic potential of an aneurysmal bone cyst.
Virchows Arch
; 2009 Nov;455(5):455-9
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Aneurysmal bone cysts (ABCs) are
benign
bone tumors consisting of blood-filled cavities lined by connective tissue septa.
Diagnosis
was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient.
Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary
tumor
.
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[ISSN]
1432-2307
[Journal-full-title]
Virchows Archiv : an international journal of pathology
[ISO-abbreviation]
Virchows Arch.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Proto-Oncogene Proteins; 2S9ZZM9Q9V / Bevacizumab; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
28.
Schiopu C, Flangea C, Capitan F, Serb A, Vukelić Z, Kalanj-Bognar S, Sisu E, Przybylski M, Zamfir AD:
Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry.
Anal Bioanal Chem
; 2009 Dec;395(8):2465-77
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We report here on a preliminary investigation of ganglioside composition and structure in human hemangioma, a
benign tumor
in the frontal cortex (HFC) in comparison to normal frontal cortex (NFC) tissue using for the first time advanced mass spectrometric methods based on fully automated chip-nanoelectrospray (nanoESI) high-capacity ion trap (HCT) and collision-induced dissociation (CID).
Fragmentation analysis by CID in MS(2) mode using as precursors the ions corresponding to GT1 (d18:1/20:0) and GD1 (d18:1/20:0) provided data corroborating for the first time the presence of the common GT1a and GT1b isomers and the incidence of unusual GT1c and GT1d glycoforms in brain hemangioma
tumor
.
[MeSH-major]
Biomarkers,
Tumor
/ metabolism. Brain Neoplasms / metabolism. Gangliosides / chemistry. Gangliosides / metabolism. Hemangioma / metabolism. Spectrometry, Mass, Electrospray Ionization / methods. Tandem Mass Spectrometry / methods
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(PMID = 19841910.001).
[ISSN]
1618-2650
[Journal-full-title]
Analytical and bioanalytical chemistry
[ISO-abbreviation]
Anal Bioanal Chem
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Gangliosides; GZP2782OP0 / N-Acetylneuraminic Acid
29.
Li X, Placencio V, Iturregui JM, Uwamariya C, Sharif-Afshar AR, Koyama T, Hayward SW, Bhowmick NA:
Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis.
Oncogene
; 2008 Nov 27;27(56):7118-30
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[Title]
Prostate
tumor
progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis.
In mice, the conditional stromal knockout of the TGF-beta type II receptor expression (Tgfbr2(fspKO)) resulted in the development of prostatic intraepithelial
neoplasia
and progression to adenocarcinoma within 7 months.
Clinically, we observed a loss of TGF-beta receptor type II expression in 69% of human prostate cancer-associated stroma, compared to 15% of stroma associated with
benign
tissues (n=140, P-value <0.0001).
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[ISSN]
1476-5594
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA108646; United States / NIGMS NIH HHS / GM / F31 GM079879; United States / PHS HHS / / FGM079879A; United States / NCI NIH HHS / CA / U54 CA126505; United States / NCI NIH HHS / CA / CA126505; United States / NCI NIH HHS / CA / R01 CA108646-04; United States / NCI NIH HHS / CA / T32 CA009592; United States / NCI NIH HHS / CA / R01 CA108646; None / None / / R01 CA108646-04
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / Ligands; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta; 0 / WNT3A protein, human; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / Wnt3A Protein; 0 / Wnt3a protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor
[Other-IDs]
NLM/ NIHMS142310; NLM/ PMC3222150
30.
Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR:
Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.
Cancer Biol Ther
; 2006 Jun;5(6):674-83
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[Title]
Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in
benign
breast and breast cancer.
Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in
benign
breast and breast cancer.
Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from
benign
breast.
However, cyclopamine reduced viability of cancer epithelial cell lines, including MDA-MB-435, but did not specifically affect fibroblasts or epithelial cells from
benign
breast, including MCF10AT.
These results demonstrate modulation of GLI-mediated transcription in both cancer and
benign
-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells.
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]
(PMID = 16855373.001).
[ISSN]
1538-4047
[Journal-full-title]
Cancer biology & therapy
[ISO-abbreviation]
Cancer Biol. Ther.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P20 CA091421; United States / NCI NIH HHS / CA / P50 CA089019; United States / NCI NIH HHS / CA / R01 CA087728; United States / NCI NIH HHS / CA / R03 CA105950
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA Primers; 0 / Hedgehog Proteins; 0 / RNA, Neoplasm; 0 / SHH protein, human; 0 / Veratrum Alkaloids; ZH658AJ192 / cyclopamine
[Other-IDs]
NLM/ NIHMS11622; NLM/ PMC1557635
31.
Chesnokova V, Melmed S:
Pituitary senescence: the evolving role of Pttg.
Mol Cell Endocrinol
; 2010 Sep 15;326(1-2):55-9
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Despite the high prevalence of pituitary adenomas they are invariably
benign
, indicative of unique intrinsic mechanisms controlling pituitary cell proliferation.
Cellular senescence is characterized by a largely irreversible cell cycle arrest and constitutes a strong anti-proliferative response, which can be triggered by DNA damage, chromosomal instability and aneuploidy, loss of
tumor
suppressive signaling or oncogene activation.
Here we discuss prospective mechanisms underlying senescence-associated molecular pathways activated in
benign
pituitary adenomas.
Both deletion and over-expression of pituitary
tumor
transforming gene (Pttg) promote chromosomal instability and aneuploidy.
Pttg deletion abrogates
tumor
development by activating p53/p21-dependent senescence pathways.
Pituitary p21 may therefore safeguard against further chromosomal instability by constraining pituitary
tumor
growth.
These observations point to senescence as a target for effective therapy for both
tumor
silencing and growth restraint towards development of pituitary malignancy.
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[Copyright]
2010 Elsevier Ireland Ltd. All rights reserved.
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J Clin Endocrinol Metab. 2001 Feb;86(2):867-74
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11158059.001
]
(PMID = 20153804.001).
[ISSN]
1872-8057
[Journal-full-title]
Molecular and cellular endocrinology
[ISO-abbreviation]
Mol. Cell. Endocrinol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA075979-11A1; United States / NCI NIH HHS / CA / R01 CA075979; United States / NCI NIH HHS / CA / R01 CA075979-11A1
[Publication-type]
Journal Article; Review
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Neoplasm Proteins; 0 / Securin; 0 / pituitary tumor-transforming protein 1, human
[Other-IDs]
NLM/ NIHMS185500; NLM/ PMC2906651
32.
Satsuka A, Sakai H:
[Life cycle of HPV governed by the differentiation program of epithelial cell].
Uirusu
; 2008 Dec;58(2):165-72
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Papillomavirus is a pathogenic virus that induces
benign tumor
at the infected lesion, and its association with malignant
tumor
was first identified by R.
Because of its clinical importance, the study on HPV has been focused on the oncogenic properties, and the results of which had great impacts on the researches of the
tumor
suppressors, such as p53 and pRb, and "ubiquiitn-proteasome" pathway.
[MeSH-minor]
Animals. Gene Expression Regulation, Viral. Gene Silencing. Genes,
Tumor
Suppressor. Genome, Viral. Humans. Open Reading Frames / genetics. Virus Replication / genetics
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(PMID = 19374194.001).
[ISSN]
0042-6857
[Journal-full-title]
Uirusu
[ISO-abbreviation]
Uirusu
[Language]
jpn
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Japan
[Number-of-references]
33
33.
Zhu X, Ma LL, Ye T:
Expression of CD4(+)CD25(high)CD127(low/-) regulatory T cells in transitional cell carcinoma patients and its significance.
J Clin Lab Anal
; 2009;23(4):197-201
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To evaluate the expressions of CD4(+)CD25(high)CD127(low/-) regulatory T cells (Tregs) in peripheral blood from patients with transitional cell carcinoma (TCC) in urinary system, we investigated the proportion of Treg population in CD4(+) T from 93 patients with TCC, 38 with
benign
urinary diseases, and 37 healthy subjects by using flow cytometric analysis and analyzing different clinicopathologic characteristics and the changes before and after operation.
There was a strong correlation between the proportion of Treg and
tumor
recurrence, quantity, lymph node metastasis (P<0.01), as well as pathological stage; no correlation was found between the proportion of Treg and clinical TNM stage (P>0.05).
The resection of
tumor
can decrease the proportion of Treg in peripheral blood.
[MeSH-major]
Antigens, CD / immunology. Biomarkers,
Tumor
/ blood. Carcinoma, Transitional Cell / immunology. T-Lymphocytes, Regulatory / immunology. Urologic Neoplasms / immunology
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(PMID = 19623656.001).
[ISSN]
1098-2825
[Journal-full-title]
Journal of clinical laboratory analysis
[ISO-abbreviation]
J. Clin. Lab. Anal.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, CD; 0 / Antigens, CD4; 0 / Biomarkers, Tumor; 0 / IL2RA protein, human; 0 / Interleukin-2 Receptor alpha Subunit; 0 / Interleukin-7 Receptor alpha Subunit
34.
Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson SJ, Vigneron DB, Gribbestad IS, Kurhanewicz J:
Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues.
Magn Reson Med
; 2008 Sep;60(3):510-6
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A long-echo-time rotor-synchronized Carr-Purcell-Meiboom-Gill (CPMG) sequence including an electronic reference to access in vivo concentrations (ERETIC) standard was used to determine the concentrations of lactate and alanine in 82
benign
and 16 malignant biopsies (mean 26.5% +/- 17.2% of core).
Low concentrations of lactate (0.61 +/- 0.28 mmol/kg) and alanine (0.14 +/- 0.06 mmol/kg) were observed in
benign
prostate biopsies, and there was no significant difference between
benign
predominantly glandular (N = 54) and stromal (N = 28) biopsies between patients with (N = 38) and without (N = 44) a positive clinical biopsy.
In biopsies containing prostate cancer there was a highly significant (P < 0.0001) increase in lactate (1.59 +/- 0.61 mmol/kg) and alanine (0.26 +/- 0.07 mmol/kg), and minimal overlap with lactate concentrations in
benign
biopsies.
This study demonstrates for the first time very low concentrations of lactate and alanine in
benign
prostate biopsy tissues.
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Magn Reson Med. 2005 Jan;53(1):41-8
[
15690501.001
]
(PMID = 18727052.001).
[ISSN]
1522-2594
[Journal-full-title]
Magnetic resonance in medicine
[ISO-abbreviation]
Magn Reson Med
[Language]
ENG
[Grant]
United States / NIBIB NIH HHS / EB / R21 EB005363-03; United States / NCI NIH HHS / CA / K01 CA96618; United States / NCI NIH HHS / CA / K01 CA096618-04; United States / NCI NIH HHS / CA / R01 CA102751; United States / NIBIB NIH HHS / EB / R21 EB05363; United States / NCI NIH HHS / CA / CA096618-04; United States / NIBIB NIH HHS / EB / EB005363-03; United States / NIBIB NIH HHS / EB / R21 EB005363; United States / NCI NIH HHS / CA / K01 CA096618
[Publication-type]
Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Lactates; OF5P57N2ZX / Alanine
[Other-IDs]
NLM/ NIHMS83785; NLM/ PMC2613807
35.
Iqbal J, Liu T, Mapow B, Swami VK, Hou JS:
Importance of flow cytometric analysis of serous effusions in the diagnosis of hematopoietic neoplasms in patients with prior hematopoietic malignancies.
Anal Quant Cytol Histol
; 2010 Jun;32(3):161-5
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[Title]
Importance of flow cytometric analysis of serous effusions in
the diagnosis
of hematopoietic neoplasms in patients with prior hematopoietic malignancies.
OBJECTIVE: To determine the criteria for the use of immunophenotyping by flow cytometry (FCM) in
the diagnosis
of hematopoietic lesions.
The cytopathologic
diagnosis
was compared with the final
diagnosis
as modified by subsequent FCM.
RESULTS: The cytopathologic
diagnosis
was
benign
in 61 cases (69%), atypical in 20 cases (22%) and malignant in 8 cases (9%).
In these patients, the working cytopathologic
diagnosis
was modified from
benign
/atypical to malignant in 2 (11%) cases and atypical to
benign
in 11 (33%) cases.
CONCLUSION: FCM studies were helpful in the cytopathologic
diagnosis
in 35% of body fluid specimens, permitting appropriate cancer staging and management.
In the absence of a prior clinical history, immunophenotyping by FCM in body fluid specimens should be ordered after adequacy studies when there is cytologic atypia or a strong suspicion of malignancy on the cytopathologic
diagnosis
.
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(PMID = 20701070.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
36.
Ranaldi R, Morichetti D, Goteri G, Martino A:
Immature teratoma of the mediastinum arising in ectopic thyroid tissue: a case report.
Anal Quant Cytol Histol
; 2009 Aug;31(4):233-8
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The histologic examination revealed the presence of a discontinuous rim of compressed thyroid follicles on the outer aspect of the
tumor
capsule.
The patient was free of disease after 22 months, in accordance with the
benign
behavior of immature teratoma in infancy.
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THYROGLOBULIN
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(PMID = 19736871.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 9010-34-8 / Thyroglobulin
37.
McLerran D, Grizzle WE, Feng Z, Bigbee WL, Banez LL, Cazares LH, Chan DW, Diaz J, Izbicka E, Kagan J, Malehorn DE, Malik G, Oelschlager D, Partin A, Randolph T, Rosenzweig N, Srivastava S, Srivastava S, Thompson IM, Thornquist M, Troyer D, Yasui Y, Zhang Z, Zhu L, Semmes OJ:
Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.
Clin Chem
; 2008 Jan;54(1):44-52
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[Title]
Analytical validation of serum proteomic profiling for
diagnosis of
prostate cancer: sources of sample bias.
METHODS: We derived the decision algorithm used in this study from the analysis of serum samples from patients with prostate cancer (n = 181) and
benign
prostatic hyperplasia (BPH) (n = 143) and normal controls (n = 220).
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[Cites]
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[CommentIn]
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[
18160722.001
]
[CommentIn]
Clin Chem. 2008 Jan;54(1):6-7
[
18160723.001
]
(PMID = 17981926.001).
[ISSN]
0009-9147
[Journal-full-title]
Clinical chemistry
[ISO-abbreviation]
Clin. Chem.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA 084986; United States / NCI NIH HHS / CA / CA 84968; United States / NCI NIH HHS / CA / P50 CA058236; United States / NCI NIH HHS / CA / P30 CA006973; United States / NCI NIH HHS / CA / CA 86368; United States / NCI NIH HHS / CA / U01 CA086402; United States / NCI NIH HHS / CA / U01 CA085067; United States / NCI NIH HHS / CA / U01 CA086323; United States / NCI NIH HHS / CA / U24 CA086368; United States / NCI NIH HHS / CA / U01 CA086368; United States / NCI NIH HHS / CA / CA 86359; United States / NCI NIH HHS / CA / CA 86402; United States / NCI NIH HHS / CA / U24 CA086359; United States / NCI NIH HHS / CA / CA 86323; United States / NCI NIH HHS / CA / U01 CA084968; United States / NCI NIH HHS / CA / CA 85067; United States / NCI NIH HHS / CA / U01 CA084986
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ NIHMS371877; NLM/ PMC3354530
38.
Hilfrich R, Hariri J:
Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker.
Anal Quant Cytol Histol
; 2008 Apr;30(2):78-82
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Fifty sections were derived from a
benign
group, 91 from low-grade (cervical intraepithelial
neoplasia
[CIN 1]) lesions and 50 from high-grade (CIN 2 and 3) lesions.
International Agency for Research on Cancer - Screening Group.
diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
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Cited by Patents in
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(PMID = 18561743.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Capsid Proteins; 0 / HPV L1 protein, Human papillomavirus; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Viral; 0 / P16 protein, human
39.
Garrison JB, Kyprianou N:
Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway.
Cancer Res
; 2006 Jan 1;66(1):464-72
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[Title]
Doxazosin induces apoptosis of
benign
and malignant prostate cells via a death receptor-mediated pathway.
In this study, the molecular events initiating this apoptotic effect were further investigated in vitro using the human androgen-independent prostate cancer cells PC-3 and the human
benign
prostate epithelial cells BPH-1.
These results show that doxazosin exerts its apoptotic effects against
benign
and malignant prostate cells via a death receptor-mediated mechanism with a potential integrin contribution towards cell survival outcomes.
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DOXAZOSIN MESYLATE
.
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Anal Quant Cytol Histol. 2000 Feb;22(1):45-54
[
10696460.001
]
(PMID = 16397262.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA107575; United States / NCI NIH HHS / CA / R01 CA107575-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Adrenergic alpha-Antagonists; 0 / Antigens, CD95; 0 / FADD protein, human; 0 / Fas-Associated Death Domain Protein; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases; NW1291F1W8 / Doxazosin
[Other-IDs]
NLM/ NIHMS19062; NLM/ PMC1850148
40.
Leelawat K, Sakchinabut S, Narong S, Wannaprasert J:
Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy.
BMC Gastroenterol
; 2009;9:30
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BACKGROUND: Cholangiocarcinoma is an aggressive
tumor
with a tendency for local invasion and distant metastases.
Timely
diagnosis
is very important because surgical resection (R0) remains the only hope for a cure.
However, at present, there is no available
tumor
marker that can differentiate cholangiocarcinoma from
benign
bile duct disease.
METHODS: This study was designed to determine whether the serum levels of MMP-7 and MMP-9 can discriminate cholangiocarcinoma patients from
benign
biliary tract disease patients in comparison to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).
We measured the level of CEA, CA19-9, MMP-7 and MMP-9 in the serum of 44 cholangiocarcinoma and 36
benign
biliary tract diseases patients.
RESULTS: Among the serum levels of CEA, CA19-9, MMP-7 and MMP-9, only the serum MMP-7 level was significantly higher in the patients with cholangiocarcinoma (8.9 +/- 3.43 ng/ml) compared to
benign
biliary tract disease patients (5.9 +/- 3.03 ng/ml) (p < 0.001).
An receiver operating characteristic (ROC) curve analysis revealed that the detection of the serum MMP-7 level is reasonably accurate in differentiating cholangiocarcinoma from
benign
biliary tract disease patients (area under curve = 0.73; 95% CI = 0.614-0.848).
CONCLUSION: Serum MMP-7 appears to be a valuable diagnostic marker in the discrimination of cholangiocarcinoma from
benign
biliary tract disease.
[MeSH-major]
Bile Duct Neoplasms /
diagnosis
. Bile Ducts, Intrahepatic. Biliary Tract Diseases /
diagnosis
. Biomarkers,
Tumor
/ blood. Cholangiocarcinoma /
diagnosis
. Matrix Metalloproteinase 7 / blood. Matrix Metalloproteinase 9 / blood
[MeSH-minor]
Adult. Aged. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood.
Diagnosis
, Differential. Female. Humans. Jaundice, Obstructive / blood. Jaundice, Obstructive /
diagnosis
. Male. Middle Aged. ROC Curve. Sensitivity and Specificity
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17919228.001
]
[Cites]
Clin Chim Acta. 2008 Mar;389(1-2):61-6
[
18155162.001
]
[Cites]
Int J Cancer. 2008 May 1;122(9):2050-6
[
18172859.001
]
(PMID = 19405942.001).
[ISSN]
1471-230X
[Journal-full-title]
BMC gastroenterology
[ISO-abbreviation]
BMC Gastroenterol
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.35 / Matrix Metalloproteinase 9
[Other-IDs]
NLM/ PMC2680894
41.
Karanikolas BD, Figueiredo ML, Wu L:
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line.
Mol Cancer Res
; 2009 Sep;7(9):1456-65
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[Title]
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a
benign
prostatic epithelial cell line.
Although this correlation means EZH2 could prove valuable as a biomarker in clinical settings, the question remains whether EZH2 is actually responsible for the initiation of these more aggressive
tumor
types.
In this study, EZH2-mediated neoplastic transformation of the normal prostate epithelial cell line
benign
prostate hyperplasia 1 (BPH1) was confirmed by in vivo
tumor
growth and in vitro colony formation.
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[ISSN]
1557-3125
[Journal-full-title]
Molecular cancer research : MCR
[ISO-abbreviation]
Mol. Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P50 CA092131-08; United States / NCI NIH HHS / CA / P50 CA092131; United States / NCI NIH HHS / CA / P30 CA016042; United States / NIAID NIH HHS / AI / P30 AI028697; United States / NCI NIH HHS / CA / R01 CA101904-07; United States / NCI NIH HHS / CA / R01 CA101904; United States / NCI NIH HHS / CA / CA101904-07
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA-Binding Proteins; 0 / Transcription Factors; 147336-22-9 / Green Fluorescent Proteins; EC 2.1.1.- / Protein Methyltransferases; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
[Other-IDs]
NLM/ NIHMS159142; NLM/ PMC2794652
42.
Herrera Espiñeira C, Fernández Valdivia J, López-Cuervo JE, Martínez Tapias J:
Textural analysis in the diagnosis of benign and malignant breast cells.
Anal Quant Cytol Histol
; 2007 Dec;29(6):365-9
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[Title]
Textural analysis in
the diagnosis
of
benign
and malignant breast cells.
OBJECTIVE: To study the discriminatory capacity of textural variables to classify the nuclei of breast
tumor
cells as
benign
or malignant, using a statistical approach.
The sample comprised 95 cases of malignant lesions and 47 cases of
benign
lesions (approximately 25 nuclei per case), and 27 textural variables were measured.
RESULTS: The variance in gray levels was the most decisive variable in the CART analysis, correctly classifying 57% and 97% of
benign
and malignant cases, respectively.
Discriminant analysis yielded the best results, correctly classifying 79% and 85% of
benign
and malignant cases, respectively.
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(PMID = 18225392.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
43.
Koebrugge B, Bosscha K, Ernst MF:
Transanal endoscopic microsurgery for local excision of rectal lesions: is there a learning curve?
Dig Surg
; 2009;26(5):372-7
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BACKGROUND: Transanal endoscopic microsurgery (TEM) is a minimally invasive technique for the local resection of
benign
and stage T1 rectal lesions in selected patients, associated with lower morbidity and mortality rates than open surgery.
Median distance of the lesion from the
anal
verge was 7.0 cm; median operating time was 90 min.
Postoperative staging revealed 77 tubulovillous adenomas, 22 stage T1, 5 stage T2 and 1 stage T3 carcinomas;
tumor
resection was radical in 86%.
TEM remains the treatment of choice for
benign
lesions and stage T1 rectal carcinomas in selected patients.
[MeSH-minor]
Aged. Aged, 80 and over. Female. Humans. Length of Stay. Male. Middle Aged.
Neoplasm
Recurrence, Local.
Neoplasm
Staging. Prospective Studies. Time Factors. Treatment Outcome
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[Copyright]
(c) 2009 S. Karger AG, Basel.
(PMID = 19923824.001).
[ISSN]
1421-9883
[Journal-full-title]
Digestive surgery
[ISO-abbreviation]
Dig Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Switzerland
44.
Shantaram M, Rao A, Aroor AR, Raja A, Rao S, Monteiro F:
Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors.
Ann Indian Acad Neurol
; 2009 Jul;12(3):162-6
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BACKGROUND: Glycoconjugate molecules expressed at the plasma membrane of mammalian cells have been reported to be associated with
tumor
progression.
The measurement of total sialic acid (TSA) and lipid-bound sialic acid (LBSA) in the cerebrospinal fluid (CSF) is suggested to be useful for
the diagnosis
of brain tumors.
OBJECTIVE: The objective of this study is to check the feasibility of using serum glycoconjugates such as TSA and LBSA as
tumor
markers in brain
tumor
patients.
The LBSA fraction was isolated from the serum of 68 brain
tumor
patients and evaluated using phosphotungstic acid and resorcinol; follow-up study was done on 23 patients.
DISCUSSION: TSA and LBSA do not have the ability to discriminate between
benign
and malignant brain tumors.
TSA and LBSA appear to be
tumor
markers of very limited value in patients with brain tumors.
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[Cites]
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1998-3549
[Journal-full-title]
Annals of Indian Academy of Neurology
[ISO-abbreviation]
Ann Indian Acad Neurol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
[Other-IDs]
NLM/ PMC2824932
[Keywords]
NOTNLM ; Brain tumors / lipid-bound sialic acid / total sialic acid / tumor markers
45.
Nese N, Kandiloglu AR, Simsek G, Lekili M, Ozdamar A, Catalkaya A, Coskun T:
Comparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin.
Anal Quant Cytol Histol
; 2010 Apr;32(2):90-101
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RESULTS: HSP47 and fascin were localized to cytoplasm, and HSP47 and fascin IR were higher in IDC and PCa than
benign
groups (p < 0.05).
Fascin expression correlated with estrogen receptor and progesterone receptor negativity,
tumor
size and stage in IDC and surgical margin status in PCa.
Although there is no relationship with recurrence or metastatic status, fascin overexpression correlated with
tumor
size, which may prompt its use as a prognostic factor in IDC.
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(PMID = 20701077.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / FSCN1 protein, human; 0 / HSP47 Heat-Shock Proteins; 0 / Microfilament Proteins
46.
Prasad NB, Somervell H, Tufano RP, Dackiw AP, Marohn MR, Califano JA, Wang Y, Westra WH, Clark DP, Umbricht CB, Libutti SK, Zeiger MA:
Identification of genes differentially expressed in benign versus malignant thyroid tumors.
Clin Cancer Res
; 2008 Jun 1;14(11):3327-37
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[Title]
Identification of genes differentially expressed in
benign
versus malignant thyroid tumors.
PURPOSE: Although fine-needle aspiration biopsy is the most useful diagnostic tool in evaluating a thyroid nodule, preoperative
diagnosis of
thyroid nodules is frequently imprecise, with up to 30% of fine-needle aspiration biopsy cytology samples reported as "suspicious" or "indeterminate."
EXPERIMENTAL DESIGN: In an attempt to identify diagnostic markers for the preoperative distinction of these lesions, we chose to study by microarray analysis the eight different thyroid
tumor
subtypes that can present a diagnostic challenge to the clinician.
RESULTS: Our microarray-based analysis of 94 thyroid tumors identified 75 genes that are differentially expressed between
benign
and malignant
tumor
subtypes.
Of these, 33 were overexpressed and 42 were underexpressed in malignant compared with
benign
thyroid tumors.
CONCLUSIONS: Our results suggest that these 12 genes could be useful in the development of a panel of markers to differentiate
benign
from malignant tumors and thus serve as an important first step in solving the clinical problem associated with suspicious thyroid lesions.
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(PMID = 18519760.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA107247-01A1; United States / NCI NIH HHS / CA / R01 CA107247-05; United States / NCI NIH HHS / CA / CA107247-01A1; United States / NCI NIH HHS / CA / R01 CA107247; United States / NCI NIH HHS / CA / R01-CA107247-01A1; United States / NCI NIH HHS / CA / CA107247-05
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ NIHMS282977; NLM/ PMC3086681
47.
Bellezza I, Neuwirt H, Nemes C, Cavarretta IT, Puhr M, Steiner H, Minelli A, Bartsch G, Offner F, Hobisch A, Doppler W, Culig Z:
Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer.
Am J Pathol
; 2006 Dec;169(6):2199-208
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To better understand the mechanisms of STAT3 regulation in
benign
and malignant prostate, we have investigated the role of suppressor of cytokine signaling (SOCS)-3.
SOCS-3 immunohistochemistry revealed a negative or weak reaction in
benign
areas, whereas its expression was detected in
tumor
tissue.
[MeSH-minor]
Apoptosis. Cell Line,
Tumor
. Cell Proliferation. Humans. Interleukin-3 / metabolism. Janus Kinases / metabolism. Male. Methylation. RNA, Small Interfering. STAT3 Transcription Factor / metabolism. Suppressor of Cytokine Signaling 3 Protein. Transfection. Up-Regulation
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(PMID = 17148681.001).
[ISSN]
0002-9440
[Journal-full-title]
The American journal of pathology
[ISO-abbreviation]
Am. J. Pathol.
[Language]
eng
[Grant]
Austria / Austrian Science Fund FWF / / W 1101
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Interleukin-3; 0 / RNA, Small Interfering; 0 / SOCS3 protein, human; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Suppressor of Cytokine Signaling 3 Protein; 0 / Suppressor of Cytokine Signaling Proteins; E0399OZS9N / Cyclic AMP; EC 2.7.10.2 / Janus Kinases
[Other-IDs]
NLM/ PMC1762483
48.
Versa-Ostojić D, Stanković T, Stemberger-Papić S, Vrdoljak-Mozetic D, Manestar M, Krasević M:
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous tumor imprints.
Anal Quant Cytol Histol
; 2008 Jun;30(3):160-8
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[Title]
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous
tumor
imprints.
OBJECTIVE: To determine the morphometric characteristics of nuclei and silver-stained nucleolar organizer regions (AgNORs) on cytologic imprints and their value in differential cytodiagnosis of
benign
, atypical proliferative (borderline) and malignant ovarian mucinous tumors.
STUDY DESIGN: Forty-six mucinous ovarian
tumor
imprints (16
benign
, 15 borderline, 15 malignant), were analyzed.
The nuclear area in
benign
tumors was larger than that in borderline tumors; malignant tumors had the highest values.
The total AgNOR area, number and relative area increased from
benign
through malignant tumors, with statistically significant differences among all groups.
By AgNOR size distribution, small AgNORs discriminate malignant from borderline and
benign
tumors.
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(PMID = 18630841.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Nuclear; 0 / nucleolar organizer region associated proteins
49.
Atallah S, Albert M, Larach S:
Transanal minimally invasive surgery: a giant leap forward.
Surg Endosc
; 2010 Sep;24(9):2200-5
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We report the clinical application of this technique and present preliminary data that show TAMIS to be an effective tool for resection of both malignant and
benign
lesions of the rectum.
Patients with biopsy-proven malignant lesions were required to undergo endorectal ultrasound preoperatively to determine
tumor
stage.
To perform TAMIS, a single-incision laparoscopic surgery port (SILS Port, Covidien) is introduced into the
anal
canal by applying steady manual pressure.
The average distance from the
anal
verge was 9.3 cm and the mean
tumor
diameter confirmed by pathology measured 2.93 cm.
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Anal
Canal. Biopsy. Endosonography. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures.
Neoplasm
Staging. Treatment Outcome
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Int J Colorectal Dis. 2008 Oct;23(10):1013-6
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[ISSN]
1432-2218
[Journal-full-title]
Surgical endoscopy
[ISO-abbreviation]
Surg Endosc
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
50.
Voss M, Trojan L, Steidler A, Weiss C, Grobholz R, Alken P, Michel MS:
Serum vascular endothelial growth factor C level in patients with prostate cancer and benign prostatic hyperplasia.
Anal Quant Cytol Histol
; 2008 Aug;30(4):199-202
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[Title]
Serum vascular endothelial growth factor C level in patients with prostate cancer and
benign
prostatic hyperplasia.
OBJECTIVE: To compare serum vascular endothelial growth factor C (VEGF-C) levels in patients with
benign
prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze VEGF-C levels in relation to clinicopathologic parameters.
There was no correlation of VEGF-C to
tumor
stage, grading or the preoperative prostate-specific antigen values.
CONCLUSION: We cannot recommend VEGF-C serum level as a marker for
tumor
growth in PCa.
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(PMID = 18773737.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor C
51.
Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y:
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
Endocr Relat Cancer
; 2007 Sep;14(3):827-37
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Its expression was found, with respect to HTU5 cells, unchanged in cells derived from a
benign
thyroid follicular
tumor
(HTU42), and significantly reduced in cell lines derived from follicular (FTC-133), papillary (B-CPAP), and anaplastic thyroid carcinomas (CAL-62 and 8305C).
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[ISSN]
1351-0088
[Journal-full-title]
Endocrine-related cancer
[ISO-abbreviation]
Endocr. Relat. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Microtubule-Associated Proteins; 0 / Piperazines; 0 / TACC3 protein, human; 639089-54-6 / VX680; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
[Other-IDs]
NLM/ PMC2216418
52.
Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL:
Protein biomarker identification in the CSF of patients with CNS lymphoma.
J Clin Oncol
; 2008 Jan 1;26(1):96-105
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We tested the hypothesis that individual CSF proteins distinguish CNS lymphoma from
benign
focal brain lesions.
ATIII RNA transcripts were identified within CNS lymphomas, and ATIII protein was localized selectively to
tumor
neovasculature.
We propose that the discovery of CSF protein biomarkers will facilitate early and noninvasive
diagnosis
in patients with lesions not amenable to brain biopsy, as well as provide improved surrogates of prognosis and treatment response in CNS lymphoma and brain metastasis.
[MeSH-major]
Biomarkers,
Tumor
/ cerebrospinal fluid. Brain Neoplasms / cerebrospinal fluid. Lymphoma / cerebrospinal fluid.
Neoplasm
Proteins / cerebrospinal fluid
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Antithrombin III / genetics. Antithrombin III / metabolism. Case-Control Studies. Chromatography, Liquid.
Diagnosis
, Differential. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoblotting. Immunoenzyme Techniques. Leukemia, Myeloid / cerebrospinal fluid. Leukemia, Myeloid / pathology. Lymphoma, B-Cell / cerebrospinal fluid. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell, Marginal Zone / cerebrospinal fluid. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, Large B-Cell, Diffuse / cerebrospinal fluid. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Non-Hodgkin / cerebrospinal fluid. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Proteomics. Sensitivity and Specificity. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization. Survival Rate
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[CommentIn]
J Clin Oncol. 2009 May 1;27(13):2302-3; author reply 2303-4
[
19332721.001
]
(PMID = 18056677.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / K23 CA100291
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 9000-94-6 / Antithrombin III
[Other-IDs]
NLM/ NIHMS612770; NLM/ PMC4134101
53.
Yan BC, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, Al-Ahmadie H, Alves V, Xiao SY, Anders RA, Hart JA:
Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.
Am J Surg Pathol
; 2010 Aug;34(8):1147-54
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The distinction of hepatocellular carcinoma (HCC) from metastatic
tumor
in the liver often presents a diagnostic challenge that carries significant impact on prognostication and therapy.
Arg-1 represents a sensitive and specific marker of
benign
and malignant hepatocytes that may ultimately prove to be a useful diagnostic tool in routine surgical pathology practice.
[MeSH-major]
Arginase / analysis. Biomarkers,
Tumor
/ analysis. Carcinoma, Hepatocellular / enzymology. Hepatocytes / enzymology. Immunohistochemistry. Liver Neoplasms / enzymology
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10955454.001
]
(PMID = 20661013.001).
[ISSN]
1532-0979
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Grant]
United States / NIDDK NIH HHS / DK / R01 DK081417; United States / NIDDK NIH HHS / DK / R01 DK081417-01; United States / NIDDK NIH HHS / DK / R01 DK081417-02
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; EC 3.5.3.1 / Arginase
[Other-IDs]
NLM/ NIHMS316258; NLM/ PMC3160135
54.
Anand BS, Verstovsek G, Cole G:
Tubulovillous adenoma of anal canal: a case report.
World J Gastroenterol
; 2006 Mar 21;12(11):1780-1
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[Title]
Tubulovillous adenoma of
anal
canal: a case report.
Tumors arising from the
anal
canal are usually of epithelial origin and are mostly squamous cell carcinoma or basal cell carcinoma.
We present a case of
benign anal
adenomas arising from
the anus
, an extremely rare
diagnosis
.
Examination revealed a 4 cm friable mass attached to
the anus
by a stalk.
The squamocolumnar junction was visible at the edges of the lesion confirming the
anal
origin of the
tumor
.
We believe the tubulovillus adenoma arose from either an
anal
gland or its duct that opens into
the anus
.
[MeSH-major]
Adenoma, Villous /
diagnosis
.
Anus
Neoplasms /
diagnosis
[MeSH-minor]
Aged.
Anal
Canal / pathology. Cell Transformation, Neoplastic. Humans. Male
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[Cites]
N Engl J Med. 1988 Sep 1;319(9):525-32
[
2841597.001
]
[Cites]
J Clin Pathol. 2005 Feb;58(2):217-9
[
15677547.001
]
[Cites]
Br J Surg. 1995 Dec;82(12):1634
[
8548224.001
]
(PMID = 16586552.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC4124358
55.
Ramirez JM, Aguilella V, Gracia JA, Ortego J, Escudero P, Valencia J, Esco R, Martinez M:
Local full-thickness excision as first line treatment for sessile rectal adenomas: long-term results.
Ann Surg
; 2009 Feb;249(2):225-8
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The selection criteria were
benign
sessile adenomas below the peritoneal reflection.
In the study period, 173 patients were operated on for an apparently
benign
rectal adenoma.
The mean distance of lower
tumor
was 7.6 cm (range, 1-18 cm), and the mean distance to upper edge was 11 cm (2-20 cm).
No statistical differences were found when comparing the histologic findings by
tumor
size, distance to the
anal
verge, or location.In 10 (5.8%) cases, the dissection was considered uncompleted because of a normal mucosa margin smaller than 1 mm.
CONCLUSIONS: In conclusion, a significant number of adenomas that we assumed preoperatively to be
benign
were already carcinomas and we were unable to find any reliable predictor to identify them.
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Anal
Canal. Female. Humans. Male. Microsurgery. Middle Aged. Proctoscopy. Risk Factors. Young Adult
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(PMID = 19212174.001).
[ISSN]
1528-1140
[Journal-full-title]
Annals of surgery
[ISO-abbreviation]
Ann. Surg.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
56.
Chen SP, Wang XP:
Effect of Simotang oral liquid on anal exhaust in patients after abdominal gynecological operation.
Chin J Integr Med
; 2006 Sep;12(3):221-3
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[Title]
Effect of Simotang oral liquid on
anal
exhaust in patients after abdominal gynecological operation.
OBJECTIVE: To study the effect of Simotang oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and
anal
exhaust after abdominal gynecological operation.
METHOD: Ninety patients with
benign tumor
who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated.
The restoration time of BS and
anal
exhaust were observed.
RESULTS: Compared with the control group, the restoration time of BS and
anus
exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P < 0.05); but the difference between the two treated groups was insignificant (P > 0.05).
CONCLUSION: Simotang oral liquid and glycerine enema both could benefit the restoration of
anal
exhaust and BS after abdominal operation.
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(PMID = 17005087.001).
[ISSN]
1672-0415
[Journal-full-title]
Chinese journal of integrative medicine
[ISO-abbreviation]
Chin J Integr Med
[Language]
eng
[Publication-type]
Journal Article; Randomized Controlled Trial
[Publication-country]
China
[Chemical-registry-number]
0 / Drugs, Chinese Herbal; PDC6A3C0OX / Glycerol
57.
Wibom C, Mörén L, Aarhus M, Knappskog PM, Lund-Johansen M, Antti H, Bergenheim AT:
Proteomic profiles differ between bone invasive and noninvasive benign meningiomas of fibrous and meningothelial subtype.
J Neurooncol
; 2009 Sep;94(3):321-31
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[Title]
Proteomic profiles differ between bone invasive and noninvasive
benign
meningiomas of fibrous and meningothelial subtype.
However, some tumors may, despite their
benign
appearance, display invasive growth behavior.
Tumor
tissue from 13 patients with fibrous (6 invasive and 7 noninvasive) and 29 with meningothelial (10 invasive and 19 noninvasive) grade I meningiomas were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI).
By analyzing the protein spectra in
benign
meningiomas we could differentiate between invasive and noninvasive growth behavior in both fibrous and meningothelial meningiomas of grade I.
[MeSH-major]
Bone Neoplasms / metabolism. Bone Neoplasms / secondary. Meningeal Neoplasms / pathology. Meningioma / pathology.
Neoplasm
Invasiveness / pathology. Proteomics
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Stereotact Funct Neurosurg. 2005;83(1):45-51
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15860936.001
]
(PMID = 19350207.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
58.
Nattkemper TW, Wismüller A:
Tumor feature visualization with unsupervised learning.
Med Image Anal
; 2005 Aug;9(4):344-51
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[Title]
Tumor
feature visualization with unsupervised learning.
Dynamic contrast enhanced magnetic resonance imaging (DCE MRI) is applied for
diagnosis
and therapy control of breast cancer.
Computer-based
diagnosis
(CAD) systems have been proposed to analyze and classify signal time curve data, extracted from hand selected ROI in the DCE MRI data.
In this paper, we apply the self-organizing map (SOM) to a set of time curve feature vectors of single voxels from seven
benign
lesions and seven malignant tumors.
Using the trained SOM, we are able to identify voxels with
benign
or malignant signal characteristics and to visualize lesion cross-sections with pseudo-colors.
[MeSH-minor]
Contrast Media.
Diagnosis
, Computer-Assisted. Female. Gadolinium DTPA. Humans
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(PMID = 15907392.001).
[ISSN]
1361-8415
[Journal-full-title]
Medical image analysis
[ISO-abbreviation]
Med Image Anal
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
59.
Cho SD, Herzig DO, Douthit MA, Deveney KE:
Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
Arch Surg
; 2008 Sep;143(9):866-70; discussion 871-2
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DESIGN: Retrospective review of patient and
tumor
characteristics, procedure, recurrence, and complications.
Mean
tumor
size was 3.0 cm (range, 0.5-11 cm) and the mean distance of the
tumor
from the
anal
verge was 4.9 cm (range, 0-10 cm).
Tumor
size did not correlate with malignancy.
There were 4 (12.5%)
benign
recurrences, all after transanal excisions.
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Biopsy. Endosonography. Female. Humans. Male. Middle Aged.
Neoplasm
Recurrence, Local / epidemiology.
Neoplasm
Recurrence, Local / pathology. Retrospective Studies
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(PMID = 18794424.001).
[ISSN]
1538-3644
[Journal-full-title]
Archives of surgery (Chicago, Ill. : 1960)
[ISO-abbreviation]
Arch Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
60.
Zhang S, Gao F, Chen LS, Tang ZJ, Liang JL, Wu Q:
[Clinical analysis of anorectal malignant melanoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2005 Jul;8(4):309-11
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The onset of symptom was hematochezia, then
anus
prolapses.
94.7% of patients had AMM within 5 cm from
anus
margin; the average
tumor
size was (3.3+/- 2.1) cm.
More than a half (54.5%) of the
tumor
was movable, 19.1% smooth surfaced, 6.6% soft textured.
Half of the patients were misdiagnosed,and over 50% of patients were misdiagnosed as
benign
disease.
Mile's operation was performed in most of patients (63%), while
anal
resection was performed in 30% of the patients.
[MeSH-major]
Anus
Neoplasms / pathology. Melanoma / pathology. Rectal Neoplasms / pathology
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consumer health - Melanoma
.
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(PMID = 16167248.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
61.
Skvortsova TE, Rykova EY, Tamkovich SN, Bryzgunova OE, Starikov AV, Kuznetsova NP, Vlassov VV, Laktionov PP:
Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation.
Br J Cancer
; 2006 May 22;94(10):1492-5
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[Title]
Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis
of tumour
-related gene methylation.
Tumour
development is characterised by the increased circulating DNA (cirDNA) concentration and by
tumour
-related changes in blood plasma DNA.
Tumour
development was shown to lead to significant changes in the distribution of cirDNA between cell-free and cell-surface-bound fractions.
Analysis of RARbeta2 and RASSF1A methylation in the total cirDNA provides 95% diagnostic coverage in breast cancer patients, 60% in patients with
benign
lesions, and is without false-positive results in healthy women.
Results of the study indicate that methylation-specific PCR of RARbeta2 and RASSF1A genes based on the total cirDNA combined with the quantitative analysis of cirDNA distribution between cell-bound and cell-free fractions in blood provide the sensitive and accurate detection and discrimination of malignant and
benign
breast tumours.
[MeSH-major]
Breast Neoplasms / blood. DNA Methylation. DNA,
Neoplasm
/ blood. DNA-Binding Proteins / genetics. Fibroadenoma / blood. Receptors, Retinoic Acid / genetics. Transcription Factors / genetics.
Tumor
Suppressor Proteins / genetics
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0007-0920
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British journal of cancer
[ISO-abbreviation]
Br. J. Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / HIC1 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / retinoic acid receptor beta
[Other-IDs]
NLM/ PMC2361269
62.
Nordgård O, Oltedal S, Kørner H, Aasprong OG, Tjensvoll K, Gilje B, Heikkilä R:
The potential of cytokeratin 20 and mucin 2 mRNA as metastasis markers in regional lymph nodes of colon cancer patients investigated by quantitative RT-PCR.
Int J Colorectal Dis
; 2009 Mar;24(3):261-8
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RESULTS: Both assays were able to detect dilutions of
tumor
cells down to one
tumor
cell in 10(6) normal lymphocytes.
CK20 and MUC2 mRNA were quantitated in 52 normal lymph nodes from 12 patients undergoing surgery for
benign
bowel diseases and in 144 primary colon tumors.
The median
tumor
level of both markers were more than 10(4)-fold higher than the highest level in normal lymph nodes, indicating that the markers had a potential for metastasis detection in a clinical context.
[MeSH-major]
Biomarkers,
Tumor
/ genetics. Colonic Neoplasms / genetics. Colonic Neoplasms / pathology. Keratin-20 / genetics. Lymph Nodes / pathology. Mucin-2 / genetics. Reverse Transcriptase Polymerase Chain Reaction
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Cell Line,
Tumor
. Female. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Lymphocytes / metabolism. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism
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[Cites]
Anal Biochem. 2006 Sep 15;356(2):182-93
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16899212.001
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[ISSN]
1432-1262
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Mucin-2; 0 / RNA, Messenger
63.
Liu J, Lau SK, Varma VA, Kairdolf BA, Nie S:
Multiplexed detection and characterization of rare tumor cells in Hodgkin's lymphoma with multicolor quantum dots.
Anal Chem
; 2010 Jul 15;82(14):6237-43
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[Title]
Multiplexed detection and characterization of rare
tumor
cells in Hodgkin's lymphoma with multicolor quantum dots.
Here, we report the use of multiplexed QDs and wavelength-resolved imaging to detect and characterize a class of low-abundant
tumor
cells in Hodgkin's lymphoma.
Known as the Hodgkin's and Reed-Sternberg (HRS) cells, this class of malignant cells is a pathological hallmark in clinical
diagnosis
, but it comprises only about 1% of the heterogeneous infiltrating cells in lymph node tissues.
The results indicate that a distinct QD staining pattern (CD15 positive, CD30 positive, CD45 negative, and Pax5 positive) can be used to not only detect Hodgkin's lymphoma but also differentiate it from
benign
lymphoid hyperplasia.
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[ISSN]
1520-6882
[Journal-full-title]
Analytical chemistry
[ISO-abbreviation]
Anal. Chem.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA108468; United States / NCI NIH HHS / CA / CA119338-01; United States / NCI NIH HHS / CA / U54CA119338; United States / NCI NIH HHS / CA / U54 CA119338; United States / NCI NIH HHS / CA / CA108468-01; United States / NCI NIH HHS / CA / R01 CA108468-01; United States / NCI NIH HHS / CA / R01CA108468; United States / NCI NIH HHS / CA / U54 CA119338-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies; 0 / Biomarkers
[Other-IDs]
NLM/ NIHMS220487; NLM/ PMC2914471
64.
Bearzi I, Mandolesi A, Arduini F, Costagliola A, Ranaldi R:
Gastrointestinal stromal tumor. A study of 158 cases: clinicopathological features and prognostic factors.
Anal Quant Cytol Histol
; 2006 Jun;28(3):137-47
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[Title]
Gastrointestinal stromal
tumor
. A study of 158 cases: clinicopathological features and prognostic factors.
RESULTS: Most of the GISTs had a
benign
behavior.
CONCLUSION: Mitotic activity is important in predicting the outcome of patients with high risk GIST who present at
diagnosis
without dissemination.
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(PMID = 16786723.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit