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1. Giblin E, Lynn D, Mortman K: Cervical hibernoma demonstrating uptake on Tc-99m lymphoscintigraphy. Clin Nucl Med; 2006 Nov;31(11):694-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A hibernoma is an uncommon, benign tumor composed of brown adipose tissue.
  • These tumors are by definition benign entities but, given their propensity for growth over time, they require complete extirpation to prevent recurrence.
  • [MeSH-minor] Female. Humans. Middle Aged. Radiopharmaceuticals / pharmacokinetics. Tissue Distribution

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  • (PMID = 17053387.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid
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2. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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3. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • The most common methods of diagnosis was transurethral resection (TURP) (n=29) and needle biopsy (n=9).
  • Infiltration around benign glands was seen in 10 (36%) cases, with predominantly small nests and AC-P.
  • An additional 11 cases showed extraprostatic extension on TURP with bladder neck invasion (n=10) or periprostatic adipose tissue invasion (n=1).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biopsy, Needle. Combined Modality Therapy. Humans. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Retrospective Studies. Transurethral Resection of Prostate

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Chahwala Q, Siddaraju N, Singh N, Goneppanavar M, Basu D: Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case. Acta Cytol; 2009 Jul-Aug;53(4):437-9
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  • BACKGROUND: Oncocytic lipoadenoma is an uncommon benign salivary gland tumor.
  • CASE: A 50-year-old woman presented with a slow-growing swelling in the left parotid region that was clinically interpreted as a soft tissue tumor, with a differential of neurofibroma/lipoma.
  • The adipose tissue background of the cytologic smears was ignored as material derived from the normal fat tissue; based on the oncocytic population of cells, a diagnosis of oncocytoma was considered.
  • However, histopathologic examination showed it to be an oncocytic lipoadenoma, a tumor we were unaware of at the time of cytodiagnosis.
  • The clinicocytopathologic correlation highlighted in our case will be useful for cytopathologists in preoperative interpretation and diagnosis.

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  • (PMID = 19697732.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Talati H, Radhi J, Popovich S, Marcaccio M: Hepatic Epithelioid Angiomyolipoma: Case Series. Gastroenterology Res; 2010 Dec;3(6):293-295
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  • : Hepatic epithelioid angiomyolipoma (AML) is a rare, benign, mesenchymal neoplasm found in both males and females, and most commonly encountered in adult females.
  • The tumor cells are strongly positive for homatropine methylbromide-45 (HMB-45) and smooth muscle actin by immunohistochemistry, which are the key markers for accurate pathological diagnosis.
  • Hepatic AML should be considered in the differential diagnosis of a well circumscribed hepatic mass, even in the absence of an adipose tissue component.

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  • (PMID = 27942312.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenoma / Epithelioid angiomyolipoma / Hepatocellular carcinoma / Liver
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6. Nga ME, Swe NN, Chen KT, Shen L, Lilly MB, Chan SP, Salto-Tellez M, Das K: PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications. Int J Exp Pathol; 2010 Feb;91(1):34-43
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  • The differential diagnosis of soft tissue tumours poses a considerable challenge for pathologists, especially adipocytic tumours, as these may show considerable overlap in clinical presentation and morphological features with many other mesenchymal neoplasms.
  • We investigated the immunohistochemical expression of PIM-1 kinase in 35 samples of soft tissue tumours using tissue microarray technology and 49 full sections of adipocytic (n = 26) and non-adipocytic tumours (n = 23).
  • Benign and malignant adipocytic tumours showed strong expression of PIM-1 while the non-adipocytic tumours were either negative or showed only weak staining for the protein.
  • Our results indicate that the expression of PIM-1 in adipose tissue may be a useful marker of adipocytic differentiation, in particular if the staining is both of high intensity and present in a unique, vacuolar pattern.
  • [MeSH-major] Adipocytes / enzymology. Biomarkers, Tumor / analysis. Neoplasms, Adipose Tissue / enzymology. Proto-Oncogene Proteins c-pim-1 / analysis. Sarcoma / enzymology
  • [MeSH-minor] Cell Differentiation. Diagnosis, Differential. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Polymerase Chain Reaction. Predictive Value of Tests. RNA, Messenger / analysis. Tissue Array Analysis. Vacuoles / enzymology

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  • (PMID = 19878356.001).
  • [ISSN] 1365-2613
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; EC 2.7.11.1 / PIM1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-pim-1
  • [Other-IDs] NLM/ PMC2812726
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7. Chirieac LR, Dekmezian RH, Ayala AG: Characterization of the myxoid variant of hibernoma. Ann Diagn Pathol; 2006 Apr;10(2):104-6
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  • Hibernomas are rare benign neoplasms composed of brown adipose tissue.
  • Histopathologic examination of the resected specimen revealed a multilobulated, tan-yellow, variegated tumor with a rubbery consistency that was separated by thick fibrous septa with interspersed collections of foamy histiocytes.
  • This report highlights recent advances that may help confirm the diagnosis and explain the differential diagnosis of this rare tumor.
  • [MeSH-major] Lipoma / diagnosis. Shoulder Joint
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 16546046.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Haskell HD, Butt KM, Woo SB: Pleomorphic adenoma with extensive lipometaplasia: report of three cases. Am J Surg Pathol; 2005 Oct;29(10):1389-93
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  • In addition, one case consists of a proliferation of spindle cells with an interesting combination of mature adipose tissue, hyaline cartilage, and bone in the absence of ductal structures.
  • The differential diagnosis, as it pertains to other fat-containing tumors (such as lipoadenoma, spindle cell lipoma, interstitial lipomatosis, and benign mesenchymoma), is discussed.
  • It is likely that the ability of myoepithelial cells to undergo various metaplasias is the cause of the unusual histologic appearances of this tumor.
  • [MeSH-minor] Adenoma / pathology. Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lipoma / pathology. Male. Mesenchymoma / pathology. Metaplasia / pathology. Middle Aged

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  • (PMID = 16160483.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol; 2010 Jan;17(1):38-41
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  • [Title] Giant hypopharyngeal atypical lipomatous tumor.
  • Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.
  • Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.
  • In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.
  • To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benign lipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.
  • The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatous tumor.
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Polyps / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20032637.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 51
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10. Kourda J, Ayadi-Kaddour A, Merai S, Hantous S, Miled KB, Mezni FE: Bilateral elastofibroma dorsi. A case report and review of the literature. Orthop Traumatol Surg Res; 2009 Sep;95(5):383-7
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  • Elastofibroma is a rare benign soft tissue lesion, typically located deep under the lower pole of the scapula.
  • It is characterized by a fibrous and adipose tissue proliferation and most frequently affects older females.
  • Its characteristic location and its specific aspect in imaging studies most often provides the diagnosis following an incidental discovery.
  • Nevertheless, anatomic and pathologic confirmation is necessary to formally rule out a malignant tumor diagnosis.
  • MRI demonstrated, in fact, two symmetrical tumor masses under each scapula.
  • [MeSH-major] Elastic Tissue. Fibroma / diagnosis. Scapula. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Ultrasonography

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19628444.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 21
  • [General-notes] NLM/ Original DateCompleted: 20091028
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11. Wang K, Wang T, Fu F, Ji ZY, Liu RG, Liao QM, Dong XZ: Electrical impedance scanning in breast tumor imaging: correlation with the growth pattern of lesion. Chin Med J (Engl); 2009 Jul 5;122(13):1501-6
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  • [Title] Electrical impedance scanning in breast tumor imaging: correlation with the growth pattern of lesion.
  • BACKGROUND: This study researched the electric impedance properties of breast tissue and demonstrated the different characteristic of electrical impedance scanning (EIS) images.
  • METHODS: The impedance character of 40 malignant tumors, 34 benign tumors and some normal breast tissue from 69 patients undergoing breast surgery was examined by EIS in vivo measurement and mammography screening, with a series of frequencies set between 100 Hz - 100 kHz in the ex vivo spectroscopy measurement.
  • Of the 30 patients with 34 benign tumors there were almost no specific abnormality shown in the EIS results.
  • Primary ex vivo spectroscopy experiments showed that the resistivity of various breast tissue take the following pattern: adipose tissue > cancerous tissue > mammary gland and benign tumor tissue.
  • CONCLUSIONS: There are significant differences in the electrical impedance properties between cancerous tissue and healthy tissue.
  • The impedivity of benign tumor is lower, and is at the same level with that of the mammary glandular tissue.

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  • (PMID = 19719937.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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12. Speer AL, Schofield DE, Wang KS, Shin CE, Stein JE, Shaul DB, Mahour GH, Ford HR: Contemporary management of lipoblastoma. J Pediatr Surg; 2008 Jul;43(7):1295-300
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  • PURPOSE: Lipoblastoma is a rare, benign, adipose tissue tumor.
  • [MeSH-major] Neoplasms, Adipose Tissue / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18639685.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Cha JM, Lee JI, Joo KR, Choe JW, Jung SW, Shin HP, Kim HC, Lee SH, Lim SJ: Giant mesenteric lipoma as an unusual cause of abdominal pain: a case report and a review of the literature. J Korean Med Sci; 2009 Apr;24(2):333-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The resected ileal segment was encased by a giant fatty tissue, and normal mucosal fold patterns of the resected ileum were effaced by the mass.
  • Microscopically, the mass was characterized by homogenous mature adipose tissue without cellular atypia, which was compatible with the diagnosis of a mesenteric lipoma.
  • Despite the benign nature of this tumor, total excision with or without the affected intestinal loop should be considered if intestinal symptoms such as abdominal pain are present.
  • [MeSH-major] Abdominal Pain / etiology. Lipoma / diagnosis. Mesentery. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Female. Humans. Ileal Diseases / etiology. Laparoscopy. Tomography, X-Ray Computed

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  • (PMID = 19399281.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2672139
  • [Keywords] NOTNLM ; Abdominal Pain / Computed Tomography / Laparoscopy / Lipoma / Mesentery
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14. Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P, Pedeutour F: Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol; 2007 Oct;31(10):1476-89
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  • [Title] Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.
  • Atypical lipomatous tumor/well-differentiated liposarcomas and dedifferentiated liposarcomas are characterized by the amplification of MDM2 and CDK4 genes.
  • To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis of adipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors.
  • First, we evaluated MDM2-CDK4 amplification and expression in a series of 94 well-defined adipose tissue tumors.
  • We then used the same techniques as complementary diagnostic tools in a series of 106 adipose and soft tissue tumors of unclear diagnosis to distinguish between (i) lipomas and atypical lipomatous tumor/well-differentiated liposarcomas, (ii) malignant undifferentiated tumors and dedifferentiated liposarcomas, and (iii) a variety of benign tumors and liposarcomas.
  • When tumor cells represented a minor component of the tumor tissue, such as with inflammatory tumors, FISH was more powerful than Q-PCR by allowing visualization of individual cells.
  • In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone.
  • [MeSH-major] Cyclin-Dependent Kinase 4 / genetics. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / diagnosis. Nucleic Acid Amplification Techniques. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adipose Tissue / metabolism. Adipose Tissue / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Paraffin Embedding. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17895748.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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15. Chien AL, Song DH, Stein SL: Two young girls with lipoblastoma and a review of the literature. Pediatr Dermatol; 2006 Mar-Apr;23(2):152-6
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  • Lipoblastoma is an uncommon, benign tumor of embryonic adipose tissue that occurs predominantly in the pediatric population.
  • Biopsy of the lesion is standard for diagnosis, as clinical and radiologic diagnoses can be misleading.
  • [MeSH-major] Lipoma / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Groin. Heel. Humans. Infant

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  • (PMID = 16650226.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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16. Kumazoe H, Nagamatsu Y, Nishi T, Kimura YN, Nakazono T, Kudo S: Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings. Jpn J Radiol; 2009 Jan;27(1):37-40
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  • Hibernoma is an uncommon, benign soft tissue tumor that arises in brown adipose tissue.
  • We report the unique appearance of a rare thoracic wall hibernoma, which appeared as a dumbbell-shaped lipomatous tumor across an intercostal region.
  • [MeSH-major] Lipoma / diagnostic imaging. Soft Tissue Neoplasms / diagnostic imaging

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  • [Cites] Am J Surg Pathol. 2001 Jun;25(6):809-14 [11395560.001]
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  • (PMID = 19373530.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Akcali Y, Karahan OI, Kahriman G, Ceyran H, Balkanli S: Angiomyolipoma with cavoatrial extension. Eur Urol; 2006 Sep;50(3):605-6
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  • Pathologic evaluation revealed a tumor consisting of mature adipose tissue, smooth muscle and vessels consistent with angiomyolipoma.
  • Our case reminds us of the rare possibility that angiomyolipoma, which is classified as a benign tumor, may invade the inferior vena cava or right atrium.
  • [MeSH-major] Angiomyolipoma / diagnosis. Heart Atria / pathology. Heart Neoplasms / diagnosis

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  • (PMID = 16828222.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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18. Changizi V, Oghabian MA, Speller R, Sarkar S, Kheradmand AA: Application of small angle X-ray scattering (SAXS) for differentiation between normal and cancerous breast tissue. Int J Med Sci; 2005;2(3):118-21
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  • [Title] Application of small angle X-ray scattering (SAXS) for differentiation between normal and cancerous breast tissue.
  • These interferences carry information about the molecular structure of the tissue and hence can be used to identify changes that occur due to cancer.
  • The optimum scattering angle, determined from a series of measurements on adipose breast tissue at several angles from 4 to 7.3 degrees, was found to be 6.5 degrees.
  • Once optimized the system was used to measure the diffraction profiles (corrected scattered intensity versus momentum transfer) of a total of 99 breast tissue samples.
  • The samples were both normal and tumour samples.
  • RESULTS: Adipose tissue showed a sharp, high intensity peak at low momentum transfer values of approximately 1.1nm-1.
  • Adipose tissue, mixed tissue (adipose & fibroglandular) and tumor have peaks at different values of momentum transfer that can be used to identify the tissue.
  • Benign and malignant breast tissues can also be differentiated by both peak positions and peak heights.
  • It was also observed that the results were reproducible even after the tissue had been preserved at liquid nitrogen temperatures.
  • CONCLUSION: We were able to differentiate between normal, benign and malignant breast tissues by using energy dispersive small angle x-ray scattering.

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  • [Cites] Phys Med Biol. 1999 Jul;44(7):1791-802 [10442713.001]
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  • (PMID = 16007264.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Other-IDs] NLM/ PMC1168877
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19. Zhang F, Xie ZJ, Ge WL, Li SL, Li YN: Tensile force produced by a lipoma in the masseteric space possibly causing hyperostosis of the angle of the mandible. Med Sci Monit; 2009 Sep;15(9):CS148-50
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  • BACKGROUND: A lipoma is a benign tumor which may occur in the adipose tissue of any part of the body.
  • The tumor is most commonly found on the trunk and extremities.
  • Although it is the most common tumor of mesenchymal origin in the head and neck, its incidence is relatively rare.
  • Lipoma of the head and neck is usually located in subcutaneous tissue.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hyperostosis / pathology. Lipoma / pathology. Mandible / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19721405.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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20. Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, Aurias A, Hostein I, Coindre JM: MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol; 2005 Oct;29(10):1340-7
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  • [Title] MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.
  • Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively.
  • We examined a series of 559 soft tissue tumors (44 ALT-WDLPS, 61 DDLPS, 49 benign adipose tumors, and 405 non-ALT-WDLPS/DDLPS sarcomas) for MDM2 and CDK4 expression using immunohistochemistry.
  • Most ALT-WDLPS/DDLPS expressed MDM2 (97%) and CDK4 (92%) as opposed to few benign adipose tumors (MDM2, 5%; CDK4, 2%) and a limited number of non-ALT-WDLSP/DDLPS sarcomas (MDM2, 19%; CDK4, 6%).
  • The sensitivity and specificity of MDM2 and CDK4 immunostainings in identifying ALT-WDLPS/DDLPS among other soft tissue tumors were 97% and 92%, and 83% and 95%, respectively.
  • MDM2 and CDK4 immunostainings were particularly useful to separate ALT-WDLPS from the large group of differentiated adipose tumors, and to distinguish DDLPS from poorly differentiated sarcomas.
  • In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
  • [MeSH-major] Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Gene Amplification. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 16160477.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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21. Nigri G, Dente M, Valabrega S, Beccaria G, Aurello P, D'Angelo F, Di Marzo F, Ramacciato G: Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Rep; 2008;2:318
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  • INTRODUCTION: Lipoma is the most frequent benign tumor of the soft tissue.
  • Although the diagnosis is mostly clinical, imaging tools are useful to confirm the adipose nature of the lesion and to define its anatomic border.
  • Subsequent magnetic resonance imaging showed a giant adipose mass developed beneath the large gluteal muscle and among the fibers of the medium and small gluteal muscles.

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  • [Cites] Br J Dermatol. 2007 Jul;157(1):92-9 [17553055.001]
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  • (PMID = 18826615.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2569952
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22. Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E: Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol; 2009 Nov 1;183(9):5948-56
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  • [Title] Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development.
  • Adipose tissue represents a rich source of multipotent stem cells.
  • Our view of adipose tissue has recently changed, establishing adipocytes as new members of the immune system, as they produce a number of proinflammatory cytokines (such as IL-6 and TNFalpha and chemokines, in addition to adipokines (leptin, adiponectin, resistin) and molecules associated with the innate immune system.
  • In this paper, we report the differential expression of TNF-superfamily members B cell activating factor of the TNF Family (BAFF), a proliferation inducing ligand (APRIL), and TNF-like weak inducer of apoptosis (TWEAK) in immature-appearing and mature adipocytes and in benign and malignant adipose tissue-derived tumors.
  • We further report the existence of functional BCMA, TACI, and Fn14 receptors and their ligands BAFF, APRIL, and TWEAK on adipose tissue-derived mesenchymal cells, their interaction modifying the rate of adipogenesis.
  • [MeSH-major] Adipocytes / immunology. Adipocytes / metabolism. B-Cell Activating Factor / biosynthesis. B-Cell Activation Factor Receptor / biosynthesis. B-Cell Maturation Antigen / biosynthesis. Receptors, Tumor Necrosis Factor / biosynthesis. Transmembrane Activator and CAML Interactor Protein / biosynthesis. Tumor Necrosis Factor Ligand Superfamily Member 13 / biosynthesis. Tumor Necrosis Factors / biosynthesis
  • [MeSH-minor] Adipose Tissue / cytology. Adipose Tissue / immunology. Adipose Tissue / metabolism. Adipose Tissue / pathology. Cell Differentiation / immunology. Cells, Cultured. Humans. Tumor Cells, Cultured

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  • (PMID = 19828625.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / B-Cell Activating Factor; 0 / B-Cell Activation Factor Receptor; 0 / B-Cell Maturation Antigen; 0 / Receptors, Tumor Necrosis Factor; 0 / TNFRSF13B protein, human; 0 / TNFRSF13C protein, human; 0 / TNFRSF17 protein, human; 0 / TNFSF12 protein, human; 0 / TNFSF13B protein, human; 0 / TWEAK receptor; 0 / Transmembrane Activator and CAML Interactor Protein; 0 / Tumor Necrosis Factor Ligand Superfamily Member 13; 0 / Tumor Necrosis Factors
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23. Sarnat HB, Flores-Sarnat L: Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J Child Neurol; 2005 Aug;20(8):637-43
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  • After dorsal closure of the neural tube, neural crest cells separate and migrate throughout the embryo to form many structures of ectodermal origin (eg, dorsal root and autonomic ganglia, peripheral nerve sheaths) and mesodermal origin (eg, blood vessels, melanocytes, adipose tissue, membranous bone, connective tissue, most of the ocular globe).
  • Abnormal angiogenesis, areas of abnormal pigmentation that sometimes follow the lines of Blashko, nerve sheath proliferations, disorders of chromaffin tissue, lipomes and benign and malignant tumors are frequent features.
  • Many defective genes in neurocutaneous syndromes have an additional function as tumor suppressors.

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  • (PMID = 16225807.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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24. Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D: Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature. Eur J Gynaecol Oncol; 2006;27(1):73-7
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  • OBJECTIVE: To study the histopathological features of mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components, and review their histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions.
  • METHODS: Ten cases of mesenchymal tumors of the uterine corpus, massively infiltrated by hematopoioetic cells, or composed of other benign heterologous elements (adipose tissue in the present cases) were retrieved from the archival files of our laboratory and studied histopathologically.
  • RESULTS: Six of our studied cases were diagnosed as leiomyomas, two as lipoleiomyomas, one as a symplastic lipoleiomyoma, and one as an endometrial stromal tumor.
  • The endometrial stromal tumor was severely infiltrated by histiocytes, and was positive for vimentin, CD10, PgR and negative for actin, desmin, ER and caldesmon.
  • CONCLUSION: The presence of hematopoietic or heterologous elements within an otherwise bland uterine leiomyoma or endometrial stromal tumor may give rise to diagnostic difficulties.
  • Regularity of the tumor margins, low mitotic activity and absence of nuclear atypia or necrosis should be established for the exclusion of a malignancy.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Disease Progression. Female. Hematopoietic System / pathology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Prognosis. Registries. Retrospective Studies. Risk Assessment

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  • (PMID = 16550975.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 37
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25. Nakamura N, Kudo A, Ito K, Tanaka S, Arii S: A hepatic lipoma mimicking angiomyolipoma of the liver: report of a case. Surg Today; 2009;39(9):825-8
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  • Radiological examinations (computed tomography, ultrasonography, magnetic resonance imaging) showed a well-defined mass, which was finally diagnosed to be located in the left part of the caudate lobe of the liver, containing two spotty enhanced nodules within the tumor.
  • The cut surface of the specimen showed an encapsulated, homogeneous, yellowish tumor consisting of mature adipose tissue, which was diagnosed as lipoma of the liver.
  • The two nodules within the tumor were encapsulated hemorrhage.
  • Therefore, the final diagnosis was lipoma of the liver, which is an extremely rare benign liver tumor.
  • [MeSH-major] Angiomyolipoma / diagnosis. Lipoma / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19779784.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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26. Siddaraju N, Singh N, Muniraj F, Jothilingam P, Kumar S, Basu D, Saxena SK: Preoperative cytodiagnosis of pleomorphic adenoma with extensive lipometaplasia: a case report. Acta Cytol; 2009 Jul-Aug;53(4):457-9
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  • BACKGROUND: Pleomorphic adenoma with extensive lipometaplasia is a rare, benign tumor of salivary gland origin.
  • Fine needle aspiration yielded sticky, fatty material; the smears showed features of pleomorphic adenoma with intimately associated, abundant adipose tissue elements.
  • CONCLUSION: Pleomorphic adenoma with extensive lipometaplasia is an unusual benign salivary gland tumor with distinct histomorphology.
  • Cytologically, it is characterized by the presence of an excessive amount of intimately associated adipose tissue in an otherwise-classic pleomorphic adenoma.
  • [MeSH-minor] Adipose Tissue / pathology. Biopsy, Fine-Needle. Humans. Male. Metaplasia / pathology. Middle Aged

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  • (PMID = 19697737.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Prud'homme A, Rousselot C, de Pinieux G, Voche P, Rosset P: [Hemosiderotic fibrohistiocytic lipomatous lesion: a new entity you must remind]. Ann Chir Plast Esthet; 2007 Dec;52(6):616-20
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  • [Title] [Hemosiderotic fibrohistiocytic lipomatous lesion: a new entity you must remind].
  • Fatty tissues lesions are the most frequent of both benign (lipoma) and malignant tumor (liposarcoma) of soft tissues in the adult.
  • We here describe the case of female patient having a fatty tissue mass of the ankle corresponding to an hemosiderotic fibrohistiocytic lipomatous lesion (HFHLL).
  • This very rare tumour of recent description is specific of the ankle/foot area of the middle age women.
  • These lesions are always benign and frequently recur following incomplete resection.
  • This tumor may have invasive local growth and metastases have not been described so far.
  • We discuss the main differentials diagnosis and treatment.
  • [MeSH-major] Hemosiderosis / complications. Histiocytic Disorders, Malignant / complications. Histiocytic Disorders, Malignant / pathology. Leiomyoma / complications. Leiomyoma / pathology. Lipoma / complications. Lipoma / pathology. Neoplasms, Adipose Tissue / complications. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 17316948.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Ito R, Fujiwara M, Takagaki K, Nagasako R: Chondrolipoma of the toe. J Dermatol; 2007 Aug;34(8):570-2
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  • Chondrolipoma is a rare benign mesenchymoma composed of mature cartilage and adipose tissue.
  • On histological examination, the tumor contained both mature fat cells and chondrocytes.
  • [MeSH-major] Foot Diseases / diagnosis. Mesenchymoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Cartilage / pathology. Humans. Magnetic Resonance Imaging. Male. S100 Proteins / analysis. Toes / pathology. Toes / radiography

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  • (PMID = 17683390.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins
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29. Kunieda E, Hara H, Morikawa Y, Hirobe S, Kamagata S, Kubo A: Accumulation of gallium-67 within mature and immature teratoma in pediatric patients: investigation for the uptake mechanism. Ann Nucl Med; 2008 Apr;22(3):207-13
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  • However, in the remaining one immature teratoma, the gallium distribution was diffuse within the tumor.
  • CONCLUSIONS: A high-uptake ratio of (67)Ga in benign teratoma was indicated.
  • A close correlation between gallium scan and CT helps to ascertain whether (67)Ga uptake results from malignant and/or immature elements, or mature tissue components.
  • [MeSH-minor] Adipose Tissue / radionuclide imaging. Adolescent. Autoradiography. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Radiopharmaceuticals / pharmacokinetics. Sacrococcygeal Region / pathology. Sacrococcygeal Region / radionuclide imaging. Tissue Distribution. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed. Whole Body Imaging

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  • (PMID = 18498036.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0 / Radiopharmaceuticals
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30. Cymet-Ramírez J, Martínez-Flores LM, Villalobos Garduño FE: [Lipoblastoma. A case report]. Acta Ortop Mex; 2007 May-Jun;21(3):151-3
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  • Lipoblastoma is an rare benign tumors of infancy of fetal adipose tissue, that usually affect infants and children less than 3 years of age.
  • The tumor was completely excised surgically.
  • The clinical diagnosis of lipoblastoma was confirmed pathologically.
  • This experience is illustrative for the orthopaedic surgeon, because it shows the importance to performe a complete clinical examination in all patients, to avoid the omission in the diagnosis of this pathology.
  • [MeSH-major] Knee. Lipoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Child, Preschool. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 17937179.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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31. de Moraes M, de Matos FR, de Carvalho CP, de Medeiros AM, de Souza LB: Sialolipoma in minor salivary gland: case report and review of the literature. Head Neck Pathol; 2010 Sep;4(3):249-52
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  • Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements.
  • Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements.
  • Both the glandular and adipose components were found in almost equal proportion.
  • No atypia in the adipose tissue was observed.
  • The definitive diagnosis was sialolipoma.
  • The age distribution was from 27 to 84 years (mean, 61.6 years) and the tumor size ranged from 0.9 to 4 cm (mean, 1.7 cm).

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  • [Cites] Histopathology. 2001 Jan;38(1):30-6 [11135044.001]
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  • (PMID = 20563675.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923305
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32. Sera H, Shimoda T, Ozeki S, Honda T: A case of chondroma of the tongue. Int J Oral Maxillofac Surg; 2005 Jan;34(1):99-100
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  • Chondroma of the tongue represents a very rare benign tumor at this site, with very few reports of pure chondroma (no components of adipose, fibrous or bony tissue) existing.
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 15617977.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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33. Mineo JF, P-Ruchoux MM, Pasquier D, Rigolle H, Assaker R: [Primitive malignant melanoma arising in a spinal nerve root. A case report]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):133-7
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  • The T1-weighted MRI images showed a tumor hyperintensity, the T2-weighted images showed tumor isointensity and mild contrast enhancement.
  • Due to the scalloping of L3/L4 foramen with root enlargement and slow evolution (more than one year between the first symptom and surgery without clinical worsening), the initial preoperative diagnosis was L3 schwannoma.
  • The tumor was composed of irregular melanocytoid cells with high proliferation index (20%).
  • So, the final diagnosis was intradural primitive malignant melanoma.
  • Radiotherapy was performed on the site of the tumor.
  • The most common tumor with root enlargement and bony scalloping is the benign schwannoma.
  • Despite the above described radiological features, MRI characteristics (hyperintensity when images are T1-weighted) suggest a melanocytic tumor, a tumor with a high adipose component or an intratumoral bleeding.
  • Specific MRI sequences can eliminate adipose tissue tumor, but diagnosis between melanin and methemoglobin is still difficult.
  • According to the index of proliferation, a primitive central melanocytic lesion can be a meningeal melanocytoma (considered as benign) or a primitive malignant melanoma.
  • The histological features of malignant lesion with benign clinical features lead to interrogation upon the actual pathologic classification.
  • [MeSH-minor] Adult. Antigens, Neoplasm. Cell Proliferation. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Melanins / metabolism. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Neurologic Examination. S100 Proteins / metabolism

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  • (PMID = 16840974.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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34. Ramírez GA, Spattini G, Altimira J, García B, Vilafranca M: Clinical and histopathological features of a thymolipoma in a dog. J Vet Diagn Invest; 2008 May;20(3):360-4
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  • This study presents a case of a canine thymolipoma, which is a rare, slow-growing, benign tumor of the thymus composed of mature adipose tissue and thymic tissue.
  • Microscopically, the mass was composed of adipose tissue with numerous cords and nests of thymic tissue without corticomedullary arrangement.
  • To the authors' knowledge, this is the first description of this uncommon neoplasm in a dog.
  • [MeSH-major] Dog Diseases / diagnosis. Lipoma / veterinary. Thymus Neoplasms / veterinary

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  • (PMID = 18460628.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Hameed M, Clarke K, Amer HZ, Mahmet K, Aisner S: Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report. Cancer Genet Cytogenet; 2007 Sep;177(2):131-4
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  • Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue.
  • The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma.
  • Herein we describe a tumor arising in the perineal region of a 60-year-old man with morphological and immunohistochemical features of cellular angiofibroma and showing cytogenetic characteristics similar to spindle cell lipoma.

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  • (PMID = 17854668.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Huang KH, Huang CY, Chung SD, Pu YS, Shun CT, Chen J: Malignant epithelioid angiomyolipoma of the kidney. J Formos Med Assoc; 2007 Feb;106(2 Suppl):S51-4
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  • Angiomyolipoma (AML) is a common benign renal tumor composed of thick-walled blood vessels, smooth muscle, and adipose tissue, but the malignant epithelioid variant is extremely rare.
  • The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.
  • Epithelioid AML is a potentially aggressive tumor.
  • HMB-45 immunoreactivity is a useful marker to make diagnosis.

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  • (PMID = 17493897.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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37. Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P: Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis. Pathol Res Pract; 2010 Jan 15;206(1):66-72
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  • Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes.
  • A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components.
  • [MeSH-minor] Disease-Free Survival. Humans. Immunohistochemistry. Lipoma / metabolism. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19346081.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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38. Cifuentes M, Calleja F, Hola J, Daviú A, Jara D, Vallejos H: [Renal angiomyolipoma rupture as a cause of lumbar pain: report of one case]. Rev Med Chil; 2008 Aug;136(8):1031-3
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  • Renal angiomyolipoma is a benign tumor formed by smooth muscle, adipose tissue and blood vessels.
  • It is commonly found incidentally and its clinical manifestations are pain and abdominal mass or spontaneous tumor rupture with retroperitoneal bleeding.

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  • (PMID = 18949188.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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39. Fernández-Sueiro JL, Pinto JA, Blanco FJ, Freire M, Veiga JA, Galdo F, González-Gay MA: Multiple parosteal lipoma associated to polyarthritis. Joint Bone Spine; 2006 Mar;73(2):202-4
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  • Parosteal lipoma is a benign adipose tissue tumor situated directly in the bone cortex.
  • We describe a patient who presented with polyarthritis associated with multiple parosteal lipomatous involvement.
  • A tissue sample from the distal portion of the forearm confirmed the presence of cumulative fat tissue with nodes of esteatonecrosis.
  • [MeSH-minor] Adipose Tissue / pathology. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Drug Therapy, Combination. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prednisone / therapeutic use. Tomography, X-Ray Computed. Wrist / pathology. Wrist / radiography

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  • (PMID = 16226479.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; VB0R961HZT / Prednisone
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40. Jung SN, Yim Y, Kwon H: Symmetric lipofibromatous hamartoma affecting digital nerves. Yonsei Med J; 2005 Feb 28;46(1):169-72
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  • Lipofibromatous hamartoma of the nerve is a benign tumor, which affects the major nerves and their branches in the human body.
  • This tumor is often found in young adults and may go through a self- limiting course.
  • However, operation is indicated when the tumor size is large or when the associated nerve compressive symptoms are present.
  • With the aid of a microscope, we dissected and removed the tumor as much as possible without sacrificing the nerve.
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Female. Humans

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  • (PMID = 15744823.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC2823046
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41. Li T, Wang L, Yu HH, Sun HC, Qin LX, Ye QH, Fan J, Tang ZY: Hepatic angiomyolipoma: a retrospective study of 25 cases. Surg Today; 2008;38(6):529-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: We report our experience of diagnosing and treating hepatic angiomyolipoma (HAML), a rare benign mesenchymal tumor.
  • All tumors were composed of varying proportions of smooth muscle, adipose tissue, and blood vessels, and showed positive immunohistochemical staining for HMB-45.
  • The definitive diagnosis of HAML is challenging and depends on the presence of HMB-45-positive myoid cells.
  • [MeSH-major] Angiomyolipoma / diagnosis. Angiomyolipoma / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / analysis. Female. Hepatectomy. Humans. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18516533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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42. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, López-Terada D, Tubbs RR, Rubin BP: Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol; 2010 Oct;23(10):1301-6
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  • Well-differentiated liposarcoma/atypical lipomatous tumor can be difficult to differentiate from benign lipomatous tumors, especially on limited biopsy material.
  • Adjunctive tests for MDM2 (murine double minute 2) have proven useful in whole-tissue sections; however, their utility has not been determined within the increasingly popular core needle biopsy.
  • Herein, we compare the ability of MDM2 immunohistochemistry and MDM2 fluorescence in situ hybridization (FISH) to discriminate benign lipomatous tumors from well-differentiated liposarcoma on core needle biopsies.
  • Well-differentiated liposarcoma (n=17) and an assortment of benign lipomatous tumors (n=37), which had concurrent or previous core needle biopsies, and resection specimens were subjected to both MDM2 immunohistochemistry and MDM2 FISH on both whole-tissue sections and corresponding core needle biopsy sections.
  • Percentage tumor cells positive for MDM2 by immunohistochemistry and an MDM2:CEP12 FISH ratio was calculated in each biopsy and resection specimen pair and the results were compared.
  • The average MDM2:CEP12 ratio was similar in the biopsy material compared with the whole-tissue sections in both well-differentiated liposarcoma and the benign lipomatous tumor group of neoplasms.
  • Detection of MDM2 amplification by FISH is a more sensitive and specific adjunctive test than MDM2 immunohistochemistry to differentiate well-differentiated liposarcoma from various benign lipomatous tumors, especially on limited tissue samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Needle. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / biosynthesis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Lipoma / diagnosis. Sensitivity and Specificity


43. Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P: Posttraumatic lipoma: fact or fiction? Skinmed; 2007 Nov-Dec;6(6):266-70
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  • Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology.
  • A link between soft tissue trauma and the formation of lipomas has been described, with the latter being named posttraumatic lipomas.
  • The average time between soft tissue trauma and lipoma formation was 2.6 years (range, 0.5-6.0 years).
  • Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases.
  • CONCLUSIONS: The pathogenetic link between soft tissue trauma and the formation of posttraumatic lipomas is still controversially discussed.
  • There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth.
  • The first is the formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact.
  • A second possibility points toward lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation.
  • [MeSH-major] Adipose Tissue / injuries. Lipoma / etiology. Neoplasms, Adipose Tissue / etiology. Wounds, Nonpenetrating / complications

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  • (PMID = 17975353.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Koplin SA, Twohig MH, Lund DP, Hafez GR: Omental lipoblastoma. Pathol Res Pract; 2008;204(4):277-81
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  • This unusual tumor is only the eighth reported omental lipoblastoma [J. Hicks, A. Dilley, D. Patel, J.
  • Goldblum, Enzinger and Weiss's Soft Tissue Tumors, fourth ed., Mosby, St. Louis, MO, 2001, pp.
  • Lakhoo, Omental lipoblastoma in a child; diagnosis based in CT density measurements. J. Pediatr. Hematol. Oncol.
  • Alvarenga, Sonographic features of benign intraperitoneal lipomatous tumors in children-report of 4 cases. Pediatr. Radiol.
  • [MeSH-major] Neoplasms, Adipose Tissue / pathology. Omentum / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 8. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Infant. Karyotyping. Liposarcoma, Myxoid / pathology. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18276084.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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45. Bartumeus Martínez P, Ripollés González T: [Extraadrenal retroperitoneal myelolipoma]. Actas Urol Esp; 2009 Apr;33(4):439-42
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  • Extraadrenal myelolipomas are rare benign tumors and differentiating them from other soft tissue tumors containing fat can be difficult.
  • Initially oriented as liposarcoma, the final diagnosis was obtained after surgery.
  • Computed tomography (CT), ultrasound (US) and magnetic resonance imaging (MRI) features may vary according to the major component of the tumor.
  • MRI with fat suppression and opposed-phase imaging are the best imaging tools to demonstrate the adipose tissue.

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  • (PMID = 19579898.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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46. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Immunohistochemistry for S100 protein, CD34, and Mib-1 was performed on formalin-fixed, paraffin-embedded tissue using standard techniques.
  • Age at diagnosis ranged from 3 months to 16 years with 22% in the first year, 68% at 1 to 9 years, and 10% at 10 to 16 years.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • Histologically, nodules of adipose and myxoid tissue were demarcated by bands of fibrous tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


47. Bougnoux P, Giraudeau B, Couet C: Diet, cancer, and the lipidome. Cancer Epidemiol Biomarkers Prev; 2006 Mar;15(3):416-21
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  • In order to circumvent the limitations and/or bias of dietary exposure assessment tools, biomarkers of past lipid intake such as the fatty acid composition of white adipose tissue have been used.
  • This article presents a reappraisal of the role of the lipid profile through a comprehensive reanalysis of adipose tissue fatty acid composition obtained in patients with benign or malignant breast tumors as well as in experimental animals during dietary interventions.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / etiology. Dietary Fats, Unsaturated / metabolism. Fatty Acids / metabolism
  • [MeSH-minor] Adipose Tissue / metabolism. Animals. Fatty Acids, Omega-3 / metabolism. Fatty Acids, Omega-6 / metabolism. Female. Humans. Rats. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 16537692.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Dietary Fats, Unsaturated; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Fatty Acids, Omega-6
  • [Number-of-references] 23
  • [Other-IDs] NLM/ HALMS68759; NLM/ PMC2755770
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48. Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M, Kubota S, Fukata S, Amino N, Kuma K: Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine; 2006 Oct;30(2):231-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.
  • Benign thyroid teratomas are rare in adolescents and adults.
  • We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.
  • The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.
  • Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.
  • The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.
  • Surgical resection was curative, and subsequent histologic examination revealed mature benign teratomas of the thyroid.
  • The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.
  • [MeSH-major] Pain / diagnosis. Teratoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasms / diagnosis

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  • (PMID = 17322585.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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49. Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM: Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat; 2010 Jan;119(2):367-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adiopcyte fatty acid binding-protein(A-FABP) is another protein found in adipose tissue;therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer.
  • In our study,200 women attending the University of Ulm for breast surgery between the years 2005 and 2007 were included;159 had histologically confirmed breast cancer; 41 had histologically confirmed benign lesions.
  • Serum levels ofA-FABP, leptin, and adiponectin were measured, and their relationship to body-mass-index (BMI), breast cancer, and tumor characteristics were analyzed; logistic regression model was adjusted to age, BMI, menopausal status, use of Hormone Replacement Therapy (HRT), and family history of breast cancer.
  • Concerning tumor characteristics,A-FABP was positively connected with tumor size (T C 2 cm, P.05) and nodal-status (P.05).Our study reveals that high A-FABP serum levels are associated with obesity, breast cancer risk, and adverse tumor characteristics.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / etiology. Fatty Acid-Binding Proteins / blood. Obesity / complications
  • [MeSH-minor] Adiponectin / blood. Adult. Aged. Body Mass Index. Case-Control Studies. Female. Humans. Leptin / blood. Logistic Models. Middle Aged. Neoplasm Staging. Odds Ratio. Postmenopause. Predictive Value of Tests. Premenopause. Risk Assessment. Risk Factors. Treatment Outcome. Up-Regulation

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  • (PMID = 19842034.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / ADIPOQ protein, human; 0 / Adiponectin; 0 / Biomarkers, Tumor; 0 / FABP4 protein, human; 0 / Fatty Acid-Binding Proteins; 0 / Leptin
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50. Sachdeva MP, Goldblum JR, Rubin BP, Billings SD: Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge. Am J Dermatopathol; 2009 Jul;31(5):423-6
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  • Pleomorphic lipomas are benign tumors that most commonly present as subcutaneous masses in the head and neck, shoulder, or back region of middle-aged to elderly men.
  • When little or no fat is present, the diagnosis can be challenging.
  • The seventh case was an intradermal tumor from the nose of a 48-year-old woman.
  • Referring diagnoses, when provided, included myxofibrosarcoma, giant cell fibroblastoma, and granulomatous rosacea for the tumor from the nose; none considered pleomorphic lipomas.
  • When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Aged. Antigens, CD34 / metabolism. Diagnosis, Differential. Female. Fibrosarcoma / pathology. Giant Cell Tumors / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Rosacea / pathology

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  • (PMID = 19542913.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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51. Lee KR, Seo TJ, Cho JH, Kim HI, Hur YH, Cho SB, Lee WS, Joo YE: [A case of large retroperitoneal lipoma mimicking liposarcoma]. Korean J Gastroenterol; 2010 Jun;55(6):394-8
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  • Lipomas are the most common benign tumors of adipose tissue among adults.
  • Laparotomy showed a large encapsulating tumor arising from retroperitoneum with fat necrosis.
  • [MeSH-major] Lipoma / diagnosis. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Fluorodeoxyglucose F18. Humans. Liposarcoma / diagnosis. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20571308.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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52. Lasalandra C, Coviello M, Falco G, Divella R, Trojano G, Laterza AM, Quero C, Pepe V, Zito FA, Quaranta M: Serum vascular endothelial growth factor and adiponectin levels in patients with benign and malignant gynecological diseases. Int J Gynecol Cancer; 2010 May;20(4):507-12
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  • [Title] Serum vascular endothelial growth factor and adiponectin levels in patients with benign and malignant gynecological diseases.
  • Adipose tissue is a major endocrine and it secretes hormones termed adipokines.
  • This study was designed to determine the serum VEGF and adiponectin levels in patients with benign and malignant gynecological diseases and if there was a correlation between serum VEGF and adiponectin.
  • Diagnosis of benign and malignant gynaecological diseases was established by biopsy.
  • RESULTS: Our results were analyzed on the basis of 2 different parameters: age and benign and malignant gynecological diseases of the patient.
  • Only for serum VEGF levels was a significant difference observed (P = 0.004) between patients with benign and malignant gynecological diseases.
  • A significantly inverse correlation between serum VEGF and adiponectin levels among patients with benign and malignant gynecological diseases was found.
  • CONCLUSIONS: This is one of the first report on adiponectin in benign and malignant gynecological diseases.
  • [MeSH-major] Adiponectin / blood. Biomarkers, Tumor / blood. Genital Diseases, Female / blood. Neoplasms / blood. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 20442584.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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53. Amin SA, Huang CC, Reierstad S, Lin Z, Arbieva Z, Wiley E, Saborian H, Haynes B, Cotterill H, Dowsett M, Bulun SE: Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. Mol Cell Endocrinol; 2006 Jul 11;253(1-2):44-55
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  • Paracrine interactions between adipose fibroblasts and malignant epithelial cells are essential for structural and hormonal support of breast tumors.
  • Here, we characterized the gene expression profile of breast adipose fibroblasts in an in vitro model of malignancy to identify other paracrine interactions that support tumor growth.
  • Primary breast adipose fibroblasts from cancer-free women were treated with conditioned media from malignant breast epithelial cells or normal breast epithelial cells, and differences in gene expression were identified by microarray.
  • Immunoreactive AKR1C3 was detected in epithelial and stromal components of benign lesions and ductal carcinomas in situ, and in 59.8% of epithelial and 69.6% of stromal cells in invasive breast carcinomas.
  • AKR1C3 expression was significantly higher in myoepithelial cells surrounding the neoplastic epithelium of ductal carcinoma in situ compared with those surrounding benign epithelial lesions.
  • Malignant epithelial cell-conditioned medium significantly increased formation of testosterone and estradiol from androstenedione in breast adipose fibroblasts.
  • [MeSH-minor] 3-Hydroxysteroid Dehydrogenases / genetics. 3-Hydroxysteroid Dehydrogenases / metabolism. Adipose Tissue / cytology. Adolescent. Adult. Aromatase / genetics. Aromatase / metabolism. Cell Line, Tumor. Cells, Cultured. Culture Media, Conditioned / pharmacology. Female. Humans. Hydroxyprostaglandin Dehydrogenases / genetics. Hydroxyprostaglandin Dehydrogenases / metabolism. Immunohistochemistry. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis

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  • (PMID = 16735089.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA67167
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / RNA, Messenger; 4TI98Z838E / Estradiol; EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 1.1.1.- / AKR1C3 protein, human; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases; EC 1.14.14.1 / Aromatase
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54. Wimmer M, Conrad EU, Eary JF: Hibernoma in the Thigh Mimicking Soft Tissue Sarcoma on FDG-PET. Radiol Case Rep; 2008;3(3):196
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  • [Title] Hibernoma in the Thigh Mimicking Soft Tissue Sarcoma on FDG-PET.
  • Hibernoma, a tumor of benign brown adipose tissue can present as a large mass that can mimic a sarcoma.
  • The FDG-PET uptake was highly avid, suggesting a preliminary diagnosis of an intermediate to high grade tumor.
  • However, brown fat is highly metabolically active, and therefore high levels of FDG uptake can be misleading for tumor characterization in treatment planning, as it was in this case.

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  • (PMID = 27303545.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4897017
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging / SUV, standard uptake value
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55. Güvenç BH, Etus V, Muezzinoglu B: Lumbar teratoma presenting intradural and extramedullary extension in a neonate. Spine J; 2006 Jan-Feb;6(1):90-3
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  • Total removal of the tumor was achieved.
  • The pathological examination showed a benign teratoma containing mature cartilage, muscle, adipose tissue, and glandular tissue.
  • CONCLUSION: Accompanying a spinal dysraphic state, the mature teratoma in our case may support the idea of a tumor actually arising from a dysraphism and growing outward to produce the mass.
  • [MeSH-major] Lumbar Vertebrae. Neoplasm Invasiveness / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Recovery of Function. Risk Assessment

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  • (PMID = 16413454.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Kim HS, Yun KJ: Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology. Diagn Cytopathol; 2008 Apr;36(4):253-6
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  • [Title] Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.
  • Adenolipomas are rare benign neoplasms composed of mature adipose tissue and thyroid follicles.
  • A FNA cytology specimen showed a few benign follicular cells with adipose tissue.
  • Microscopic findings showed a solid tumor predominantly composed of mature adipose tissue intermixed with thyroid follicles.
  • The pathological diagnosis was adenolipoma of the thyroid gland.
  • The presence of adipose tissue is a common finding within the cytologic specimen, especially in obese individuals or with inadequate sampling.
  • But suspicion may be possible if excess amounts of adipose tissue are present in the submitted sample.
  • [MeSH-major] Lipoma / diagnosis. Thyroid Neoplasms / diagnosis

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335547.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Smith CS, Teruya-Feldstein J, Caravelli JF, Yeung HW: False-positive findings on 18F-FDG PET/CT: differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values. AJR Am J Roentgenol; 2008 Apr;190(4):1091-6
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  • [Title] False-positive findings on 18F-FDG PET/CT: differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values.
  • OBJECTIVE: Hibernoma is a benign tumor of brown fat that has imaging features similar to those of malignant fat-containing soft-tissue tumors.
  • CONCLUSION: Variation in standardized uptake values over time is an imaging characteristic that may be helpful for differentiating hibernoma and malignant fatty tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Neoplasms, Adipose Tissue / radiography. Neoplasms, Adipose Tissue / radionuclide imaging. Radiopharmaceuticals. Tomography, Emission-Computed. Tomography, X-Ray Computed
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. False Positive Reactions. Female. Humans. Lipoma / radiography. Lipoma / radionuclide imaging. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18356460.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Akbulut M, Zekioglu O, Terek MC, Ozdemir N: Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor. Arch Gynecol Obstet; 2008 Sep;278(3):283-6
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  • [Title] Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor.
  • OBJECTIVE: Adenofibroma is a form of mixed mesodermal tumor in which epithelial and stromal components are benign, and usually arises in the endometrium of postmenopausal women.
  • We report a case of lipoadenofibroma of the endometrium that appeared as an intracavitary mass, which is very unusual because endometrioid adenofibroma rarely contains mature adipose tissue, only the second such case described in detail.
  • The endometrial polypoid mass was found to be a lipoadenofibroma composed predominantly of collagenated fibrous stroma populated by cystically dilated and occasionally crowded glands lined with proliferative endometrium, intermingled with abundant mature adipose tissue.
  • CONCLUSION: We suggest that uterine adenofibromas with lipomatous areas belong to the family of mixed tumor of Mullerian origin.
  • [MeSH-major] Adenofibroma / pathology. Endometrial Neoplasms / pathology. Mixed Tumor, Mullerian / pathology

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  • (PMID = 18236054.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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59. Wells WA, Wang X, Daghlian CP, Paulsen KD, Pogue BW: Phase contrast microscopy analysis of breast tissue: differences in benign vs. malignant epithelium and stroma. Anal Quant Cytol Histol; 2009 Aug;31(4):197-207
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  • [Title] Phase contrast microscopy analysis of breast tissue: differences in benign vs. malignant epithelium and stroma.
  • OBJECTIVE: To assess how optical scatter properties in breast tissue, as measured by phase contrast microscopy and interpreted pathophysiologically, might be exploited as a diagnostic tool to differentiate cancer from benign tissue.
  • STUDY DESIGN: We evaluated frozen human breast tissue sections of adipose tissue, normal breast parenchyma, benign fibroadenoma tumors and noninvasive and invasive malignant cancers by phase contrast microscopy through quantification of grayscale values, using multiple regions of interest (ROI).
  • RESULTS: Stroma demonstrated significantly higher scatter intensity than did epithelium, with lower scattering in tumor-associated stroma as compared with normal or benign-associated stroma.
  • Measures were comparable for invasive and noninvasive malignant tumors but were higher than those found in benign tumors and were lowest in adipose tissue.
  • CONCLUSION: Significant differences were found in scatter coefficient properties of epithelium and stroma across diagnostic categories of breast tissue, particularly between benign and malignant-associated stroma.

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  • (PMID = 19736867.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U54 CA105480-010002; United States / NCI NIH HHS / CA / U54 CA105480; None / None / / U54 CA105480-010002; United States / NCI NIH HHS / CA / CA080139-09; United States / NCI NIH HHS / CA / P01 CA080139; United States / NCI NIH HHS / CA / P01 CA080139-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS183687; NLM/ PMC2857332
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60. Lin MS, Hung YS, Wu HH, Kuo MC, Shiu TF, Chuang CK, Shih LY, Chu PH: Polycythemia vera as a presentation of renal angiomyolipoma: a case report. J Med Case Rep; 2009;3:90
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  • INTRODUCTION: Angiomyolipoma is a common benign renal tumor composed of thick-walled blood vessels, smooth muscle, and adipose tissue.
  • The report discusses the differential diagnosis using erythropoietin, erythropoietin-receptor and Janus kinase 2.
  • Surgical intervention for this renal tumor should be avoided unless malignancy or renal cell carcinoma is suspected or to prevent spontaneous rupture of larger tumors.

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  • (PMID = 19946506.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783089
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61. Omori M, Toyoda H, Hirai T, Ogino T, Okada S: Angiomyofibroblastoma of the vulva: a large pedunculated mass formation. Acta Med Okayama; 2006 Aug;60(4):237-42
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  • Angiomyofibroblastoma is a rare, usually small benign mesenchymal tumor that occurs in vulvar lesions of premenopausal women.
  • The maximum dimension of the tumor measured 11 cm.
  • The resected tumor was well circumscribed with a bulging and glistening cut surface.
  • In the present case, intralesional adipose tissue was present throughout the tumor.
  • There was little stromal mucin throughout the tumor.
  • [MeSH-major] Hemangioma / surgery. Neoplasms, Muscle Tissue / surgery. Vulvar Neoplasms / surgery

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  • (PMID = 16943862.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Trahan S, Erickson-Johnson MR, Rodriguez F, Aubry MC, Cheville JC, Myers JL, Oliveira AM: Formation of the 12q14-q15 amplicon precedes the development of a well-differentiated liposarcoma arising from a nonchondroid pulmonary hamartoma. Am J Surg Pathol; 2006 Oct;30(10):1326-9
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  • Pulmonary hamartoma is a benign neoplasm that rarely recurs or undergoes malignant transformation.
  • Herein, we report a 48-year-old woman with a history of an incomplete excised nonchondroid pulmonary hamartoma presenting as an indolent tumor recurrence.
  • Excision of the tumor revealed a well-differentiated liposarcoma arising from the hamartomatous component.
  • These findings suggest that the formation of the 12q14-q15 chromosome amplicon, the characteristic cytogenetic finding of well-differentiated liposarcomas and the structural genomic component of the supernumerary ring and giant rod chromosomes, occurred before the morphologic changes characteristic of these malignant adipose tissue tumors and likely represents a very early molecular event in their development.

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  • (PMID = 17001166.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / HMGA2 Protein; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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63. Gheith S, Boulay R, Cornfield D: Small lymphocytic lymphoma/chronic lymphocytic leukemia in a pelvic myelolipoma. Int J Clin Exp Pathol; 2009;2(1):95-8
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  • Myelolipoma is a rare benign tumor composed of mature adipose tissue and normal hematopoietic elements.
  • The likeliest scenario is that an unusual benign tumor (myelolipoma) was colonized by a relatively common systemic hematopoietic neoplasm SLL/CLL, producing a collision tumor.

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  • (PMID = 18830383.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Extra adrenal myelolipoma / chronic lymphocytic leukemia / lymphoma / non-Hodgkin lymphoma / small lymphocytic lymphoma
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64. Wang X, Pogue BW, Jiang S, Dehghani H, Song X, Srinivasan S, Brooksby BA, Paulsen KD, Kogel C, Poplack SP, Wells WA: Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography. J Biomed Opt; 2006 Jul-Aug;11(4):041106
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  • [Title] Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography.
  • A method for image reconstruction of the effective size and number density of scattering particles is discussed within the context of interpreting near-infrared (NIR) tomography images of breast tissue.
  • Then the method was used in NIR patient images, and it indicates that for a cancer tumor, the effective scatterer size is smaller than the background breast values and the effective number density is higher.
  • In contrast, for benign tumor patients, there is not a significant difference in effective scatterer size or number density between tumor and normal tissues.
  • The method was used to interpret magnetic resonance imaging-coupled NIR images of adipose and fibroglandular tissues, and it indicated that the fibroglandular tissue has smaller effective scatterer size and larger effective number density than the adipose tissue does.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Infrared Rays. Refractometry / methods. Tomography, Optical / methods

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  • (PMID = 16965134.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01CA80139; United States / NCI NIH HHS / CA / U54CA105480
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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65. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Ogütcen-Toller M, Sener I, Kasap V, Cakir-Ozkan N: Maxillary myxoma: surgical treatment and reconstruction with buccal fat pad flap: a case report. J Contemp Dent Pract; 2006 Feb 15;7(1):107-16
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  • Myxoma is a benign tumor that arises from mesenchymal tissue and is found less commonly in the bone than in soft tissue.
  • The buccal fat pad (BFP) is a lobulated mass of fatty tissue in the oromaxillofacial region, which has long been a source of grafts in facial augmentation.
  • [MeSH-major] Adipose Tissue / transplantation. Maxillary Neoplasms / surgery. Myxoma / surgery. Oral Surgical Procedures / methods
  • [MeSH-minor] Adult. Bone Substitutes. Bone Transplantation. Cheek. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Oroantral Fistula / surgery. Reconstructive Surgical Procedures. Surgical Flaps. Tomography, X-Ray Computed

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  • (PMID = 16491153.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / OsteoGraf-N
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67. Arzanian MT, Khaleghnejad-Tabari A, Shamsian BS, Jadali F, Gharib A, Esfahani H: Generalized myelolipoma. Arch Iran Med; 2006 Jul;9(3):274-6
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  • Myelolipoma is a benign tumor originating from hematopoietic and adipose tissue.
  • This tumor usually develops in the adrenal gland, but rare presentations of extraadrenal myelolipoma are also reported, which usually arise from the presacral region.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adrenal Gland Neoplasms / diagnosis. Myelolipoma / diagnosis. Orbital Neoplasms / diagnosis. Thoracic Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16859067.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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68. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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69. Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K, Sarangi R: Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int; 2006 Jul;32(5):630-7
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  • [Title] Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study.
  • Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements concentration as a diagnostic marker and/or its etiological involvement in the disease.
  • Blood, tumor tissue and breast adipose tissue from tumor free area from each patient of the two groups, collected at the time of lumpectomy or mastectomy (only blood sample was collected from disease free control group), were analyzed to determine the concentration of Pb, Zn, Cu, Fe and Ca using Atomic Absorption Spectrometry.
  • Blood lead was significantly higher in malignant cases than in those of benign and control (p<0.05 each).
  • Lead level was also higher in tumor tissue when compared with their respective normal tumor free breast tissue, though non-significant, in both benign and malignant cases.
  • Interestingly, Zn, Fe, and Ca levels were higher in blood of malignant cases than in those of their benign counterparts.
  • Furthermore, these metals were also higher in tumor of malignant and benign cases as compared to normal tumor free breast tissue, many of them statistically significant (p<0.05/0.01/0.001).
  • However, Cu level was insignificantly lower in the blood and tumor tissue of malignant cases when compared with their benign counterparts while it was significantly higher (p<0.05) in tumor of benign cases when compared with those of their respective normal tumor free breast tissue.
  • There were statistically significant correlations between lead and trace element levels only in normal tumor free breast tissue of benign and malignant cases (r=0.41-0.73; p<0.05-0.001) but neither in blood nor tumor tissue of the two groups.
  • Further, modulation of trace elements level in both benign and malignant breast diseases patients may be of potential to be used as diagnostic marker of the disease process and its possible relationship etiologically.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Mammary Glands, Human / metabolism. Trace Elements / blood

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  • (PMID = 16580070.001).
  • [ISSN] 0160-4120
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Trace Elements
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70. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Cao D, Srodon M, Montgomery EA, Kurman RJ: Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature. Int J Gynecol Pathol; 2005 Apr;24(2):196-200
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  • [Title] Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature.
  • Angiomyofibroblastoma (AMF) is a rare, benign, mesenchymal tumor occurring mainly in the female genital tract.
  • Some cases contain scattered mature adipocytes, but the lipomatous variant in which mature adipose tissue is prominent or striking is rare.
  • We report two more such cases that were composed of 70 to 80% and 30 to 40% adipose tissue, respectively.
  • Immunohistochemical analysis showed that the tumor cells were positive for estrogen receptor, progesterone receptor, vimentin, and Bcl-2, and negative for cytokeratin AE1/1, EMA, and CD117.
  • Tumor cells in the first case were positive for CD34 but not desmin and muscle-specific actin.
  • The opposite expression profile of these three markers was observed in tumor cells in the second case: positive for desmin and muscle-specific actin and negative for CD34.
  • Rare cells were positive for S-100 in adipose-rich areas in the first case.
  • Our findings indicate that the tumor cells in the lipomatous variant have similar immunoprofile to those of usual AMF and support the concept that the lipomatous variant probably represents an extreme end of a wide spectrum of differentiation in AMF.
  • [MeSH-minor] Adipose Tissue / metabolism. Adipose Tissue / pathology. Adult. Biomarkers, Tumor. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Myxoma / pathology

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  • (PMID = 15782077.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Parratt MT, Gokaraju K, Spiegelberg BG, Miles J, Cannon SR, Briggs TW: Myolipoma affecting the erector spinae: a case report in a child. Case Rep Med; 2009;2009:520126
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  • Myolipoma is a rare, benign, lipomatous tumour which most commonly occurs in the retroperitoneum, pelvis, and abdomen.
  • Magnetic Resonance Imaging (MRI) revealed a soft tissue lesion with high fat content and areas of calcification.
  • Excision and histopathological analysis revealed a tumour composed of lobules of mature adipose tissue and broad septa of well-differentiated smooth muscle tissue.
  • This paper represents the youngest patient diagnosed with this rare soft tissue tumour which is normally confined to the adult population.
  • A newly reported site of the tumour is also highlighted.

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  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
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73. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA: C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer; 2010 Sep;49(9):810-8
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  • Chondroid lipoma, a rare benign adipose tissue tumor, may histologically resemble myxoid liposarcoma or extraskeletal myxoid chondrosarcoma, but is genetically distinct.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20607705.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA036727-24S59009; United States / NCI NIH HHS / CA / 5 P30 CA036727-2452; United States / NCI NIH HHS / CA / P30 CA036727-24S59009; United States / NCI NIH HHS / CA / U-10-CA98543-091
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MKL2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS203810; NLM/ PMC2904421
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74. Kern MA, Kasper HU, Drebber U, Guntinas-Lichius O, Veelken F, Ortmann M: [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component]. Laryngorhinootologie; 2005 Jun;84(6):432-5
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  • [Title] [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component].
  • Myoepitheliomas of the salivary glands are rare benign tumors composed of spindle-shaped myoepithelial cells, but may show plasmacytoid, epitheloid and clear cell-types that principally exhibit myoepithelial but not ductal differentiation.
  • Lipomatosis in the form of isolated small islands or scattered single lipocytes, is quite uncommon, and a large amount of adipose tissue in a pleomorphic adenoma and myoepithelioma is a rarity and only described in major salivary glands.
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male

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  • (PMID = 15940575.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Yong M, Raza AS, Greaves TS, Cobb CJ: Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report. Diagn Cytopathol; 2005 Feb;32(2):110-3
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  • Pleomorphic lipoma is a rare soft-tissue tumor, most commonly seen in the head and neck regions of middle-aged men.
  • Aspiration of the mass showed a hypocellular specimen with atypical large and floret cells with fragments of mature fibroadipose tissue in the background.
  • Based on the clinical and cytomorphological findings, a diagnosis of pleomorphic lipoma was suggested, and it was confirmed on excision.
  • This case highlights the need to be aware of unusual benign lesions that may arise in the head and neck region.
  • Knowledge of these benign lesions will help in making the correct cytological diagnosis when these lesions are sampled by FNA.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / pathology. Lipoma / pathology

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15637670.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Kushida Y, Haba R, Kobayashi S, Ishikawa M, Doi T, Kadota K: Ectopic hamartomatous thymoma: a case report with immunohistochemical study and review of the literature. J Cutan Pathol; 2006 May;33(5):369-72
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  • Ectopic hamartomatous thymoma (EHT) is a rare benign tumor.
  • The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously.
  • Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.
  • [MeSH-major] Choristoma / pathology. Hamartoma / pathology. Soft Tissue Neoplasms / pathology. Thymoma. Thymus Neoplasms
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD1 / metabolism. Antigens, CD20 / metabolism. Antigens, CD34 / metabolism. Antigens, CD45 / metabolism. Cell Adhesion Molecules / metabolism. Diagnosis, Differential. Humans. Keratins / metabolism. Male. Nerve Sheath Neoplasms / pathology. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Vimentin / metabolism

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  • (PMID = 16640545.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD1; 0 / Antigens, CD20; 0 / Antigens, CD34; 0 / CD1a antigen; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin; 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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77. Dreux N, Marty M, Chibon F, Vélasco V, Hostein I, Ranchère-Vince D, Terrier P, Coindre JM: Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases. Mod Pathol; 2010 Dec;23(12):1657-66
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  • The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors.
  • We thus analyzed 880 cases on tissue microarray and 182 cases on whole sections (211 adipocytic tumors, 628 sarcomas, 213 benign mesenchymal tumors, and 10 normal adipose tissues).
  • A nuclear immunostaining was detected in 86% of conventional and intramuscular lipomas, in 86% of well-differentiated liposarcomas and in 67% of dedifferentiated liposarcomas, as opposed to 16% of other benign adipose tumors and to 15% of non-well-differentiated liposarcoma/dedifferentiated liposarcoma sarcomas.
  • Among benign mesenchymal tumors and lesions, it was detected in 90% of nodular fasciitis and in 88% of benign fibrous histiocytomas with respective specificities of 85 and 100%, and in 90% of aggressive angiomyxoma, contrary to other vulvovaginal tumor types, which expressed HMGA2 only rarely.
  • The normal adipose tissue was always negative for HMGA2.
  • Although not specific, immunohistochemical detection of the HMGA2 protein is helpful for the distinction of normal adipose tissue from well-differentiated lesions, particularly on biopsy or on re-excision.
  • It is less sensitive than MDM2/CDK4 for dedifferentiated liposarcomas diagnosis, but it appears more specific to distinguish dedifferentiated liposarcomas from other poorly differentiated sarcomas.
  • Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. HMGA2 Protein / biosynthesis. Neoplasms, Connective and Soft Tissue / diagnosis. Neoplasms, Connective and Soft Tissue / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis

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  • (PMID = 20834238.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein
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78. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.
  • The tumor was removed by an endolaryngeal approach.
  • [MeSH-major] Angiomyolipoma / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Deglutition Disorders / diagnosis. Follow-Up Studies. Humans. Laryngoscopy. Male. Microsurgery. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Craig WD, Fanburg-Smith JC, Henry LR, Guerrero R, Barton JH: Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics; 2009 Jan-Feb;29(1):261-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Retroperitoneal lesions represent a broad, diverse collection of entities; when they contain fat, the differential diagnosis, which ranges from benign to fully malignant lesions, substantially narrows.
  • Hibernoma is a rare benign soft-tissue tumor composed of brown fat.
  • Teratomas are neoplasms that originate in pluripotent cells--benign or malignant germ cells--that give rise to a wide spectrum of mature or immature tissues that are foreign to the location in which they arise and which demonstrate varying amounts of organ formation.
  • Myelolipoma, a benign tumor composed of mature fat and interspersed hematopoietic elements that resemble bone marrow, typically originate in an otherwise normal adrenal gland.
  • Angiomyolipoma is composed of varying admixtures of blood vessels, smooth muscle cells, and adipose tissue; any one or two of these elements may predominate.
  • [MeSH-major] Intra-Abdominal Fat / pathology. Intra-Abdominal Fat / radiography. Lipomatosis / diagnosis. Lipomatosis / pathology. Neoplasms, Adipose Tissue / diagnosis. Neoplasms, Adipose Tissue / pathology. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / pathology

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  • (PMID = 19168848.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Nazeer T, Kee KH, Ro JY, Jennings TA, Ross J, Mian BM, Shen SS, Suh JH, Lee MJ, Ayala AG: Intraprostatic adipose tissue: a study of 427 whole mount radical prostatectomy specimens. Hum Pathol; 2009 Apr;40(4):538-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraprostatic adipose tissue: a study of 427 whole mount radical prostatectomy specimens.
  • Tumor Gleason grade and stage provide extremely valuable prognostic information and play an important role in therapeutic decision making and patient counseling.
  • A biopsy or radical prostatectomy specimen revealing carcinoma extending into extraprostatic tissue permits a T3 classification.
  • This is most easily recognized, particularly in a needle biopsy, when tumor is seen to invade the adipose tissue.
  • The existence of intraprostatic adipose tissue is somewhat controversial.
  • To investigate this, formalin-fixed paraffin-embedded whole-mount radical prostatectomy specimens from 427 patients with adenocarcinoma were evaluated for intraprostatic adipose tissue.
  • Intraprostatic adipose tissue was identified in 17 (3.98%) of cases.
  • In 13 cases, the fat was intimately associated with benign glands.
  • Intraprostatic adipose tissue was located in the peripheral zone in 15 cases and in the central zone in 2.
  • Intraprostatic adipose tissue, although uncommon, does exist.
  • The small size of foci of adipose tissue and its admixture with benign glands are useful morphologic clues in distinguishing it from extraprostatic fat.
  • [MeSH-major] Adenocarcinoma / pathology. Adipose Tissue / anatomy & histology. Prostatic Neoplasms / pathology

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  • [CommentIn] Hum Pathol. 2011 May;42(5):759 [21492748.001]
  • (PMID = 19121845.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Ozcan C, Görür K, Talas D, Aydin O: Intramuscular benign lipoma of the sternocleidomastoid muscle: a rare cause of neck mass. Eur Arch Otorhinolaryngol; 2005 Feb;262(2):148-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramuscular benign lipoma of the sternocleidomastoid muscle: a rare cause of neck mass.
  • Intramuscular benign lipoma commonly is found on the extremities, but is extremely rare in the head and neck region.
  • Intramuscular type lipomas arise between the muscle fibers and pass through the intermuscular septa, infiltrating the surrounding tissue.
  • CT examination revealed a lobulated, well-circumscribed 5.5x2.5-cm diameter mass with adipose tissue signal density inside the SCM muscle.
  • This rare entity should be considered in the differential diagnosis of intramuscularly located neck masses.
  • Complete removal of the tumor can only succeed if planned and performed after a thorough preoperative clinical and radiological assessment in order to prevent recurrences.

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  • [Cites] Otolaryngol Head Neck Surg. 2001 Dec;125(6):658-60 [11743474.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 1988 Dec;114(12):1480-2 [3190880.001]
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  • (PMID = 15197561.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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82. Previgliano CH, Sangster GP, Simoncini AA, Carbó AI, González E, Li B, D'Agostino H: Parosteal lipoma of the rib: a benign condition that mimics malignancy. J La State Med Soc; 2010 Jan-Feb;162(1):40-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parosteal lipoma of the rib: a benign condition that mimics malignancy.
  • They are composed of adipose tissue adjacent to the bone cortex and elicit bony reactive changes.
  • Albeit a benign condition, PL imaging findings may be misinterpreted as a malignant lesion.
  • Lipomas are benign tumors consisting of mature fat cells.
  • They are the most common mesenchymal neoplasias and account for 50% of all soft tissue tumors.
  • Musculoskeletal lipomatous lesions may be located in bones, soft tissues, and may also affect joint and tendon sheaths.
  • PL is a rare benign deep fatty-tissue tumor that arises contiguous to the periosteum without originating from it.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 20336957.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Jung SJ, Shen SS, Tran T, Jun SY, Truong L, Ayala AG, Ro JY: Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature. Hum Pathol; 2008 Mar;39(3):463-8
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  • [Title] Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature.
  • We present 2 cases of mixed epithelial and stromal tumor of the kidney with sarcomatous transformation.
  • The resected tumor involved the right renal parenchyma, measuring 13.0 x 8.0 x 4.0 cm, and extended to perirenal adipose tissue.
  • The tumor measured 6.0 x 5.5 x 4.0 cm, with an intact capsule at the upper pole.
  • Sections of both tumors revealed benign and malignant components.
  • The benign component consisted of multilocular cysts and fibrous stroma with a focally ovarian stromalike component.
  • We report 2 additional cases of sarcomatous transformation in mixed epithelial and stromal tumor of the kidney.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma / metabolism. Carcinoma / pathology. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 18261632.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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84. Kazakov DV, Hes O, Hora M, Sima R, Michal M: Primary intranodal cellular angiolipoma. Int J Surg Pathol; 2005 Jan;13(1):99-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiolipoma is a distinct, benign soft tissue tumor that most commonly occurs in young males as multiple small, subcutaneous, tender to painful nodules with predilection for the forearms.
  • Microscopically, the major portion of the lymph node was replaced by mature metaplastic adipose tissue.
  • The most recognized examples are pigmented nevi, palisading myofibroblastoma, various benign epithelial inclusions, serous cystic tumors of borderline malignancy, and hyperplastic mesothelial inclusions.
  • As we present in this report, angiolipoma is another neoplasm whose primary occurrence in the lymph node should not be misinterpreted as a metastatic tumor or malignant vascular tumor.
  • [MeSH-major] Angiolipoma / pathology. Lymph Nodes / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Antigens, CD31 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Lymphatic Metastasis / diagnosis. Male. Metaplasia / pathology

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  • (PMID = 15735863.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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85. Knight CS, Cerfolio RJ, Winokur TS: Angiomyolipoma of the anterior mediastinum. Ann Diagn Pathol; 2008 Aug;12(4):293-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyolipoma is a benign tumor composed of varying proportions of smooth muscle cells, blood vessels, and adipose tissue that most commonly occurs in the kidney.
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Melanoma-Specific Antigens. Middle Aged. Muscle, Smooth / pathology. Neoplasm Proteins / metabolism. Thymoma / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18620999.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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86. Mohan Rao PS, Moorthy N, Shankarappa RK, Bhat P, Nanjappa MC: Giant mediastinal thymolipoma simulating cardiomegaly. J Cardiol; 2009 Oct;54(2):326-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thymolipomas are rare anterior mediastinal tumors composed of mature adipose tissue and benign thymic tissue and they may rarely simulate cardiomegaly on chest radiograph.
  • The tumor was successfully removed en bloc through a median sternotomy.
  • We emphasize the importance of considering mediastinal tumors as a differential diagnosis in patients with progressive dyspnea without any obvious cause and chest radiograph showing enlarged cardiac silhouette.
  • [MeSH-major] Lipoma / diagnosis. Mediastinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cardiomegaly. Diagnosis, Differential. Dyspnea / etiology. Humans. Male. Radiography, Thoracic. Tomography, Spiral Computed

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  • (PMID = 19782275.001).
  • [ISSN] 1876-4738
  • [Journal-full-title] Journal of cardiology
  • [ISO-abbreviation] J Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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87. Leuschner I: [Lipofibromatosis in a 6-year-old girl: a case report]. Pathologe; 2010 Mar;31(2):150-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipofibromatosis is a typical soft tissue lesion of childhood which is most likely underdiagnosed.
  • The case of a 6-year-old girl with a palmar tumor is presented.
  • The lesion showed a typical fascicular growth patter into the fatty tissue.
  • Differential diagnosis includes fibrous hamartoma of infancy.
  • Lipofibromatosis is a benign disease but recurrences are not unusual.
  • [MeSH-major] Fibroma / pathology. Lipomatosis / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Child. Diagnosis, Differential. Female. Hand / pathology. Humans. Neoplasm Invasiveness

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  • [Cites] Am J Surg Pathol. 2000 Nov;24(11):1491-500 [11075850.001]
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  • (PMID = 20076960.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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88. Oishi K, Fukuda S, Sakimoto H, Eto T, Takahashi M, Nishida T: Angiomyolipoma of the colon: report of a case. Surg Today; 2009;39(11):998-1001
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyolipomas are benign mesenchymal tumors mostly arising from the kidney.
  • Here we report the findings of a 51-year-old man who presented with a submucosal tumor covered with normal mucosa and hemorrhage in the descending colon.
  • A histopathological examination showed that the tumor of 5.7 cm in diameter included smooth muscle (spindle cell type), mature adipose tissue, and vessels, and therefore a diagnosis of angiomyolipoma was made.
  • When colonoscopy shows a submucosal tumor of the colon with hemorrhage, angiomyolipoma should be considered.
  • [MeSH-minor] Biopsy. Colonoscopy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Cites] Am J Surg Pathol. 2002 Apr;26(4):523-9 [11914633.001]
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  • (PMID = 19882325.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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89. Ucak A, Inan K, Onan B, Yilmaz AT: Resection of intrapericardial hibernoma associated with constrictive pericarditis. Interact Cardiovasc Thorac Surg; 2009 Oct;9(4):717-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hibernoma is a benign soft-tissue tumor, which arises from the remnants of fetal brown adipose tissue.
  • When the tumor increases in size, this benign pathology can lead to compression of cardiac chambers and cause life-threatening complications in an asymptomatic patient.
  • The tumor was excised and diagnosed as hibernoma.

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  • (PMID = 19596706.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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90. Suzuki T, Ueda Y, Shincho M, Mitsui Y, Higuchi Y, Maruyama T, Kondoh N, Nojima M, Yamamoto S, Hirota S, Shima H: [Myolipoma arising from the renal capsule: a case report]. Hinyokika Kiyo; 2008 May;54(5):349-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Computed tomorraphy and magnetic resonance imaging showed that the tumor was mixed with muscle and fat tissue, faintly enhanced, and located at the lower portion of the left kidney.
  • Although renal angiomyolipoma (AML) was suspected from these findings, we could not rule out a malignant tumor.
  • Histopathological examination revealed the tumor composed of smooth muscle and mature adipose tissue without cytological atypia arising from the renal capsule.
  • The tumor contained no AML-like blood vessels, and was negative for HMB-45 staining.
  • The final diagnosis was myolipoma arising from the renal capsule.
  • Myolipoma is a rare benign neoplasm in the soft tissue of retroperitoneum and abdominal cavity.
  • Since it is difficult to distinguish myolipoma from other benign and malignant tumors with fat tissue only by imaging studies, a surgical approach should be considered.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 18546859.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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91. Kim HK, Choi YH, Cho YH, Sohn YS, Kim HJ: Intercostal neuralgia caused by a parosteal lipoma of the rib. Ann Thorac Surg; 2006 May;81(5):1901-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parosteal lipoma is an extremely rare benign tumor that is composed mainly of mature adipose tissue, and it has an intimate relationship to the underlying periosteal bone.
  • Although parosteal lipoma is asymptomatic, motor and sensory function deficits have been reported that were caused by the tumor compressing the neuromuscular bundles in the proximal forearm and the sciatic nerve.
  • [MeSH-minor] Adipose Tissue / pathology. Female. Humans. Middle Aged. Neuralgia / etiology. Tomography, X-Ray Computed

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  • (PMID = 16631705.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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92. Gurel D, Kargi A, Lebe B: Pedunculated cutaneous spindle cell/pleomorphic lipoma. J Cutan Pathol; 2010 Sep;37(9):e57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell/pleomorphic lipoma is an infrequently seen benign adipose tissue tumor.
  • This tumor, mostly arising from the subcutaneous tissue, usually affects male patients and occurs in back, shoulders, head and neck area.
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Dermis / pathology. Humans. Male. Vimentin / metabolism

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  • (PMID = 19678825.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Vimentin
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93. Bancroft LW, Kransdorf MJ, Peterson JJ, O'Connor MI: Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skeletal Radiol; 2006 Oct;35(10):719-33
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  • [Title] Benign fatty tumors: classification, clinical course, imaging appearance, and treatment.
  • Lipoma is the most common soft-tissue tumor, with a wide spectrum of clinical presentations and imaging appearances.
  • Several subtypes are described, ranging from lesions entirely composed of mature adipose tissue to tumors intimately associated with nonadipose tissue, to those composed of brown fat.
  • The imaging appearance of these fatty masses is frequently sufficiently characteristic to allow a specific diagnosis.
  • However, in other cases, although a specific diagnosis is not achievable, a meaningful limited differential diagnosis can be established.
  • The purpose of this manuscript is to review the spectrum of benign fatty tumors highlighting the current classification system, clinical presentation and behavior, spectrum of imaging appearances, and treatment.
  • [MeSH-major] Neoplasms, Adipose Tissue / classification. Neoplasms, Adipose Tissue / diagnosis. Neoplasms, Adipose Tissue / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Lipoma / classification. Lipoma / diagnosis. Lipoma / therapy. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16927086.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 65
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94. Kim TS, Song SY, Han J, Shim YM, Jeong HS: Giant fibrovascular polyp of the esophagus: CT findings. Abdom Imaging; 2005 Nov-Dec;30(6):653-5
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  • Giant fibrovascular polyp of the esophagus is a rare intraluminal benign tumor that is covered with normal esophageal mucosa, which consists of fibrous tissue, adipose tissue, and vascular structures.

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  • (PMID = 16132431.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N: Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg; 2009 Oct;198(4):566-74
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  • [Title] Rapid noninvasive optical imaging of tissue composition in breast tumor margins.
  • Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors.
  • Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering.
  • Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002).
  • CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.

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  • (PMID = 19800470.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024128; United States / NCRR NIH HHS / RR / UL1 RR024128-01; United States / NCRR NIH HHS / RR / 1UL1 RR024128-01
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS137679; NLM/ PMC2764289
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96. Solak O, Esme H, Sahin DA, Aktepe F: Giant intraosseous lipoma of the rib. Thorac Cardiovasc Surg; 2007 Jun;55(4):273-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoma is defined as a benign tumor consisting of a circumscribed mass of adipose tissue.
  • Lipoma of the rib is an extremely rare disorder presenting diagnostic challenges.
  • [MeSH-major] Bone Neoplasms / diagnosis. Lipoma / diagnosis. Ribs

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  • (PMID = 17546564.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Gamss C, Chia F, Chernyak V, Rozenblit A: Giant hemorrhagic myelolipoma in a patient with sickle cell disease. Emerg Radiol; 2009 Jul;16(4):319-22
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  • Adrenal myelolipoma is a rare, benign tumor consisting of adipose tissue and hematopoetic elements.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Anemia, Sickle Cell / complications. Myelolipoma / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Hemoglobin, Sickle. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 18665404.001).
  • [ISSN] 1438-1435
  • [Journal-full-title] Emergency radiology
  • [ISO-abbreviation] Emerg Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Hemoglobin, Sickle
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98. Wani NA, Kosar T, Rawa IA, Qayum A: Giant adrenal myelolipoma: Incidentaloma with a rare incidental association. Urol Ann; 2010 Sep;2(3):130-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adrenal myelolipoma is an unusual, benign and biochemically inactive tumor that is composed of mature adipose and hematopoietic tissue.

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  • (PMID = 20981204.001).
  • [ISSN] 0974-7834
  • [Journal-full-title] Urology annals
  • [ISO-abbreviation] Urol Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2955231
  • [Keywords] NOTNLM ; Adrenal gland / Bochdalek hernia / multidetector-row CT / myelolipoma
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99. Eyzaguirre E, Liqiang W, Karla GM, Rajendra K, Alberto A, Gatalica Z: Intraosseous lipoma. A clinical, radiologic, and pathologic study of 5 cases. Ann Diagn Pathol; 2007 Oct;11(5):320-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraosseous lipoma is an uncommon tumor of bone with indistinct radiologic features that makes it diagnostically challenging to radiologists and pathologists.
  • There is a need to familiarize these physicians with the radiographic and pathologic features of this lesion for the correct diagnosis.
  • Plain radiographs of the long bones revealed well-circumscribed benign-appearing osteolytic lesions with sclerotic margins, whereas in the skull, a poorly defined lytic aggressive-looking lesion was observed.
  • Microscopically, mature adipose tissue with fat necrosis, absence of hematopoietic elements, and dystrophic calcification corresponding to the calcified matrix seen on the plain radiographs were seen.
  • The osteolytic skull lesion had large caliber thin-walled vasculature with occasional fibrin thrombi mimicking intramuscular hemangiomas of soft tissue.
  • On plain radiographs, an intraosseous lipoma is usually seen as a rather benign-appearing osteolytic bone lesion with well-defined margins and a heavily calcified/ossified dense matrix.
  • Plain radiographs alone cannot establish the diagnosis of intraosseous lipoma as it mimics several other benign and malignant bone lesions.
  • Intraosseous lipoma often contains calcified necrotic fat with little mature adipose tissue and characteristically induces expansion/remodeling of the affected bone.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Skull / pathology. Skull / radiography. Tibia / pathology. Tibia / radiography. Tomography, X-Ray Computed

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  • (PMID = 17870016.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Ide H, Terado Y, Nakagawa T, Saito K, Kamiyama Y, Muto S, Okada H, Imamura T, Horie S: Incidentally discovered adrenal myelolipoma associated with hyperthyroidism. Int J Clin Oncol; 2007 Oct;12(5):379-81
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  • Such tumors are composed of mature adipose tissue and hematopoietic elements, but their etiology is still unknown.
  • We report a case of adrenal myelolipoma in a patient with hyperthyroidism; this benign tumor expressed both thyroid hormone receptor alpha and beta.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hyperthyroidism / complications. Incidental Findings. Myelolipoma / diagnosis

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  • (PMID = 17929121.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Thyroid Hormone Receptors alpha; 0 / Thyroid Hormone Receptors beta
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