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Items 1 to 45 of about 45
1. Singh S, Shivamurthy DM, Agarwal R: Pleomorphic adenoma of the soft palate. J Maxillofac Oral Surg; 2010 Mar;9(1):76-7

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  • Pleomorphic adenoma is the commonest benign salivary gland tumour, accounting for almost three fourths of all such tumours.
  • Pleomorphic adenoma most commonly occurs in the parotid gland; however it is also encountered in the submandibular, sublingual and minor salivary glands.Almost half of all salivary gland tumours are malignant, pleomorphic adenoma is the commonest benign lesion.A case of pleomorphic adenoma arising denovo in the minor salivary glands is discussed.

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1988 Sep;66(3):323-33 [2845326.001]
  • [Cites] Int J Oral Maxillofac Surg. 1986 Dec;15(6):777-9 [3027209.001]
  • [Cites] Head Neck Surg. 1986 Jan-Feb;8(3):177-84 [3744850.001]
  • (PMID = 23139574.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453680
  • [Keywords] NOTNLM ; Minor salivary gland tumours / Pleomorphic adenoma
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2. Nakabayashi M, Shomori K, Kiya S, Shiomi T, Nosaka K, Ito H: Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report. Yonago Acta Med; 2010 Sep;53(3):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report.
  • Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells.
  • We report on a female patient with BCA that developed in the right parotid gland in her 50s.
  • The present patient demonstrated a few tumor nests in the fibrous capsule, and her tumor was larger than usual.
  • Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm.
  • It was difficult to determine whether the ductal structures noted in the tumor capsule were invasive.
  • By immunohistochemistry, tumor cells of the tubular nests were positive for cytokeratin 7 and that the outer cells of tubular nests were positive for alpha smooth muscle actin (αSMA) and calponin.
  • Tumor cells were immuno-negative for S-100 protein and glial fibrillary acidic protein.
  • We could achieve an accurate diagnosis of BCA by immunohistochemistry with MIB-1 and other markers.

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  • (PMID = 24031120.001).
  • [ISSN] 0513-5710
  • [Journal-full-title] Yonago acta medica
  • [ISO-abbreviation] Yonago Acta Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3763784
  • [Keywords] NOTNLM ; basal cell adenoma / immunohistochemistry / parotid gland
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3. Pereira MC, Pereira AA, Hanemann JA: Immunohistochemical profile of canalicular adenoma of the upper lip: a case report. Med Oral Patol Oral Cir Bucal; 2007 Jan;12(1):E1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Canalicular adenoma is an uncommon benign salivary gland neoplasm that has a marked predilection for occurrence in the upper lip.
  • This tumor has an excellent prognosis after conservative surgical treatment in all locations.
  • A comparison of the immunohistochemical features of canalicular adenoma with other salivary gland neoplasms that share similar histological features is discussed.

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  • (PMID = 17195820.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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4. Ekhar VR, Mahore DM: Huge pleomorphic adenoma of nasal cavity. Indian J Otolaryngol Head Neck Surg; 2007 Sep;59(3):293-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is a common benign tumour of the salivary gland that has elements of both epithelial and mesenchymal tissue.
  • It is commonly seen in major salivary glands, parotid being the most common site followed by submandibular gland.
  • However it can sometimes arise from minor salivary glands that are distributed throughout the upper aerodigestive tract and paranasal sinuses.

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  • [Cites] Indian J Otolaryngol Head Neck Surg. 2005 Apr;57(2):163-6 [23120164.001]
  • [Cites] Ear Nose Throat J. 1997 Aug;76(8):548-50, 552, 554-7 [9282462.001]
  • (PMID = 23120457.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452111
  • [Keywords] NOTNLM ; Lateral rhinotomy / Nasal cavity / Nasal septum / Pleomorphic adenoma
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5. Párraga-Linares L, Aguirre-Urízar JM, Berini-Aytés L, Gay-Escoda C: Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Nov;14(11):e597-600
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  • [Title] Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands.
  • Papillary cystadenoma lymphomatosum is a benign salivary gland tumor most frequently located in the parotid gland (Warthin's tumor).
  • Its presentation in other major, or in minor, salivary glands is rare.
  • Clinically, it manifests as a slow growing tumor, fluctuant on palpation due to its cystic morphology.
  • The treatment of choice is complete excision with wide tumor-free margins.
  • We present a 73-year-old female patient with an asymptomatic tumor of 8 years evolution in the right posterior area of the hard palate.
  • The lesion was re-operated, performing the excision with CO2 laser and including the periosteum to ensure complete resection of the tumor.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19680204.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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6. Gorai S, Numata T, Kawada S, Nakano M, Tamaru J, Kobayashi T: Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature. Tohoku J Exp Med; 2007 Jun;212(2):199-205
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  • [Title] Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature.
  • Warthin's tumor (WT), so-called adenolymphoma, is a benign salivary gland tumor with both epithelial and lymphoid histological characteristics, so the histogenesis remains unclear.
  • Treatment consists primarily of tumor removal or conservative follow up.
  • The histological diagnosis was malignant lymphoma, diffuse large B-cell type, arising from heterotopic WT.
  • Tumor removal or careful follow up is recommended in patients with WT because of the potential risk posed by such malignant transformation.

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  • (PMID = 17548964.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
  • [Number-of-references] 28
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7. Marques YM, de Lima Mde D, de Melo Alves Sde M Jr, Soares FA, de Araújo VC, Pinto Ddos S Jr, Mantesso A: Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland. Oral Oncol; 2008 Sep;44(9):903-8
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  • [Title] Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
  • The pAkt protein is closely related to Mdm2, and has not been previously reported in salivary gland tumors.
  • In conclusion, the signaling pathway in benign salivary gland neoplasm showed an important participation of Mdm2 overexpression protein in tumor formation, progression through inactivation of p53 action, or both, and of pAkt overexpression through increased translocation of Mdm2 protein to cellular nuclei.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-mdm2 / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Cell Line, Tumor. Genes, p53 / genetics. Humans. Immunohistochemistry. Mutation. Signal Transduction / genetics

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  • (PMID = 18485798.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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8. Michaelidis IG, Stefanopoulos PK, Sambaziotis D, Zahos MA, Papadimitriou GA: Sialolipoma of the parotid gland. J Craniomaxillofac Surg; 2006 Jan;34(1):43-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sialolipoma of the parotid gland.
  • A case of slow-enlarging mass of the parotid region in a 44-year-old male is presented, which proved to be a lipomatous tumour of the parotid gland.
  • The clinical impression was that of a benign salivary gland tumour.
  • The tumour was situated in the deep lobe of the gland, thus a total parotidectomy was performed, with preservation of the facial nerve.
  • This tumour has been recently recognized as a separate entity under the term 'sialolipoma'.
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Facial Nerve / pathology. Follow-Up Studies. Humans. Male. Parotid Gland / innervation

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  • (PMID = 16343917.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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9. Widziszowska A, Namysłowski G, Hajduk A, Lange D: [Parapharyngeal oncocytoma of the parotid gland--case report]. Otolaryngol Pol; 2007;61(2):195-7

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  • [Title] [Parapharyngeal oncocytoma of the parotid gland--case report].
  • Oncocytoma is a rare, benign salivary gland tumour with slowly course.
  • It usually occurs in the parotid gland, seldom in submandibular gland.
  • This report presents a case of parapharyngeal oncocytoma of the left parotid gland in 77-year-old patient, treated in 2nd ENT Department of Medical University of Silesia in Zabrze.
  • On the basis of physical examination and preoperative radiologic studies (computed tomography scan of nasopharynx, magnetic resonance imaging, Doppler ultrasonography of carotid and vertebral arteries) the extensiveness of the tumour was determined and the surgical procedure was undertaken.
  • The removal of a whole tumour was performed through a cervical--transpharyngeal approach with midline mandibulotomy.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Magnetic Resonance Imaging. Parotid Gland / radiography. Parotid Gland / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17668810.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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10. Liess BD, Lane RV, Frazier S, Zitsch RP 3rd: Bilateral canalicular adenoma of the parotid gland. Arch Otolaryngol Head Neck Surg; 2006 Mar;132(3):339-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral canalicular adenoma of the parotid gland.
  • Canalicular adenoma is a rare benign salivary gland tumor that occurs almost exclusively in the upper lip.
  • Rarely, this benign tumor may occur multifocally in the oral cavity.
  • We report a case of canalicular adenoma in bilateral parotid glands, discuss histological characteristics, and review this tumor.

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  • (PMID = 16549756.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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11. Perez DE, Lopes MA, de Almeida OP, Jorge J, Kowalski LP: Plasmacytoid myoepithelioma of the palate in a child. Int J Paediatr Dent; 2007 May;17(3):223-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Myoepithelioma is a rare benign salivary gland tumour, localized most frequently in the parotid and in minor intraoral salivary glands.
  • The diagnosis was consistent with myoepithelioma, plasmocytoid variant.
  • Tumour cells were positive for cytokeratins, vimentin and S-100 protein.
  • Surgical resection was performed and no evidences of tumour recurrence were observed after 6 years of the treatment.
  • CONCLUSION: Myoepithelioma is a very rare tumour in children and apparently presents a good prognosis, similar to occur in adult patients.

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  • (PMID = 17397468.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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12. Siddaraju N, Singh N, Muniraj F, Jothilingam P, Kumar S, Basu D, Saxena SK: Preoperative cytodiagnosis of pleomorphic adenoma with extensive lipometaplasia: a case report. Acta Cytol; 2009 Jul-Aug;53(4):457-9
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  • BACKGROUND: Pleomorphic adenoma with extensive lipometaplasia is a rare, benign tumor of salivary gland origin.
  • CONCLUSION: Pleomorphic adenoma with extensive lipometaplasia is an unusual benign salivary gland tumor with distinct histomorphology.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19697737.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Borzym-Kluczyk M, Olszewska E, Radziejewska I, Lewszuk A, Zwierz K: Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study. Clin Chem Lab Med; 2008;46(1):131-6
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  • [Title] Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study.
  • BACKGROUND: Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many diagnostic problems.
  • N-acetyl-beta-hexosaminidase (HEX) is a lysosomal exoglycosidase involved in degradation of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans, known as a potential tumour marker.
  • The aim of our study was to evaluate HEX A and HEX B activity in healthy and PA human salivary glands using colorimetric and isoelectrofocusing methods.
  • METHODS: PA (n=8) and macroscopically unchanged salivary glands (n=8), served as controls, were used for the study.
  • RESULTS: Total activity of HEX, as well as HEX A and HEX B, in PA specimens determined by a colorimetric method was significantly higher compared with normal human salivary gland specimens.
  • After isoelectrofocusing, in normal human salivary and PA glands, two sets of HEX isoforms were found corresponding to HEX A and HEX B.
  • CONCLUSIONS: The present data indicate that HEX activity and activity of its isoenzymes in tumour specimens is significantly and consistently elevated, and thus suggest the need for further studies on the degradation of glycoconjugates, both in healthy salivary glands and PA.
  • It appears that HEX may be considered as a new tumour marker in these salivary gland diseases.

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  • (PMID = 18034640.001).
  • [ISSN] 1434-6621
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isoenzymes; EC 3.2.1.52 / Hexosaminidase A; EC 3.2.1.52 / Hexosaminidase B; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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14. Alcure ML, Della Coletta R, Graner E, Di Hipolito O Jr, Lopes MA: Sialolithiasis of minor salivary glands: a clinical and histopathological study. Gen Dent; 2005 Jul-Aug;53(4):278-81
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  • [Title] Sialolithiasis of minor salivary glands: a clinical and histopathological study.
  • Sialolithiasis is one of the most common disorders of particular major salivary glands.
  • It is caused by sialolith within the ducts or parenchyma of particularly major salivary glands.
  • Although sialolithasis is not uncommon, it often is clinically misdiagnosed when minor salivary glands are affected.
  • This article describes the clinical and microscopic findings of nine cases of sialolithiasis of minor salivary glands.
  • The most common clinical hypotheses for diagnosis were mucocele, sialoadenitis, and benign salivary gland tumor.
  • Sialolithiasis of minor salivary glands was misdiagnosed frequently.
  • It should be considered as a possible diagnosis when swelling of the oral tissues is observed.
  • [MeSH-major] Salivary Gland Calculi / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Aged. Cheek. Diagnosis, Differential. Female. Humans. Lip. Male. Middle Aged. Mouth Mucosa

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  • (PMID = 16158797.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Freedman LS, Oberman B, Sadetzki S: Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am J Epidemiol; 2009 Nov 1;170(9):1178-85
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  • [Title] Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk.
  • The authors aimed to elucidate the relation of the time-dependent smoking history parameters--age at smoking initiation and smoking intensity, duration, and latency--to the risk of Warthin's tumor, a benign tumor of the salivary gland for which cigarette smoking is a strong risk factor.
  • They studied 117 cases of Warthin's tumor and 336 matched controls included in an Israeli nationwide case-control study of parotid gland tumors conducted from 2002 to 2003 by using the Cox regression model with time-dependent covariates, with age as the time axis.
  • The relation of smoking variables to Warthin's tumor agrees with the patterns reported for lung cancer.
  • [MeSH-major] Adenolymphoma / etiology. Salivary Gland Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 19755633.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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16. Das DK, Haji BE, Ahmed MS, Hossain MN: Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. Acta Cytol; 2005 Jan-Feb;49(1):65-70

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  • [Title] Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report.
  • BACKGROUND: Myoepithelioma is a rare, benign tumor of the salivary gland, most commonly affecting the parotid gland.
  • Red to purple, myxoid matrix was present as a scanty fibrillar substance and as globules surrounded by tumor cells vaguely reminiscent of adenoid cystic carcinoma.
  • Histopathology of the resected tumor and immunohistochemical staining confirmed the cytodiagnosis of myoepithelioma.
  • CONCLUSION: FNA cytologic features together with immunocytochemical studies on smears can offer a preoperative diagnosis of myoepithelioma.
  • [MeSH-major] Myoepithelioma / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 15717758.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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17. Ben-Izhak O, Akrish S, Nagler RM: Ki67 and salivary cancer. Cancer Invest; 2008 Dec;26(10):1015-23
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  • [Title] Ki67 and salivary cancer.
  • We examined Ki67 expression in salivary malignancies of 75 patients with a follow-up period of up to 20 years.
  • Median survival for reduced-stained-tumor patients (< or = 5%) was 163 months, dropping significantly to 39 months (p = 0.0005) for enhanced stained tumors (> 5%); 5 year survival probability was 93% and 33%, respectively, 45% and 16%, respectively, (p = 0.0005) at 20 years.
  • Significant correlation between poor survival and concurrently altered expression rates of Ki67 and p53, p27 Skp2, TUNEL and heparanase in the salivary malignancies indicates a biological role in salivary cancer pathogenesis.
  • [MeSH-major] Ki-67 Antigen / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Cell Division. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Probability. RNA, Messenger / genetics. S-Phase Kinase-Associated Proteins / genetics. Survival Analysis. Tumor Suppressor Protein p53 / genetics. Young Adult

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  • (PMID = 19093259.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / RNA, Messenger; 0 / S-Phase Kinase-Associated Proteins; 0 / Tumor Suppressor Protein p53
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18. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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19. Ben Brahim E, Ferchiou M, Khayat O, Zribi S, M'barek C, Labbène N, El Khedim A, Ben Ayed M, Chadli-Debbiche A: [Tumors of salivary glands: anatomical study and clinical epidemiology of a series of 180 cases]. Tunis Med; 2010 Apr;88(4):240-4
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  • [Title] [Tumors of salivary glands: anatomical study and clinical epidemiology of a series of 180 cases].
  • [Transliterated title] Les tumeurs des glandes salivaires: etude anatomo-clinique et. Epidemiologique d'une série de 180 cas.
  • BACKGROUND: The salivary gland tumors are rare (less than 3% of all tumors) and poorly known.
  • AIM: This work aims to point at the different histological types of salivary gland tumors, to draw out the principal epidemiological, clinical, radiological and histological characteristics, and to compare our cases to those of the literature.
  • METHODS: Accordingly, we performed a descriptive type study about 180 cases of salivary gland tumors from the departments of pathology and oto-rhino-laryngology of Habib Thameur hospital during 25 years, extending from April 1979 to December 2004.
  • RESULTS: Benign tumors were predominant (88%), while malignant ones represented 12% of our cases dominated by carcinomas.
  • Parotid gland location was the most frequent one, and pleomorphic adenoma was the most frequent tumor (62%).
  • CONCLUSION: Histological diversity of salivary tumors results in difficulties for differential diagnosis.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20446256.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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20. Akrish S, Peled M, Ben-Izhak O, Nagler RM: Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis. Oral Oncol; 2009 Dec;45(12):1044-50
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  • [Title] Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis.
  • The classification system for malignant salivary gland tumors (MST) is largely dependent on its histogenesis.
  • Fifty six primary major and minor gland MST were stained with anti-cox-2 antibody and rated with a combined score that added a scale of intensity to the percentage of tumor cells that overexpressed the cox-2 protein.
  • Tumor types were segregated by morphology, histological features and proposed histogenesis.
  • Strong cox-2 overexpression was noted in all MST of proposed excretory duct origin: salivary duct carcinoma (100%), mucoepidermoid carcinoma (MEC) (92%), and adenocarcinoma nos (AdC nos) (83%).
  • Strong cox-2 overexpression was noted in the epidermoid cells of MEC, abluminal duct cells surrounding the duct-like structures and ductal cells of AdC nos and salivary duct carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cyclooxygenase 2 / analysis. Salivary Gland Neoplasms / enzymology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19729335.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2
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21. Ben-Izhak O, Akrish S, Gan S, Nagler RM: Skp2 and salivary cancer. Cancer Biol Ther; 2009 Jan;8(2):153-8
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  • [Title] Skp2 and salivary cancer.
  • Salivary malignancies are rare, heterogeneous, unpredictable in clinical behavior and seldom studied.
  • Skp2 expression was examined in salivary malignancies (n = 75) for a prolonged period (20 years).
  • Median patient survival for reduced-stained-tumor patients (< or =4%) was 143 months and significantly lower, 49 months (p = 0.016), for enhanced-stained-tumor patients (>4%).
  • Significant correlations between poor survival and significantly altered expression rates of Skp2, p27, p53, TUNEL and heparanase in salivary malignancies, suggest a biological role in salivary cancer pathogenesis for these 5 markers.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Gene Expression Regulation, Neoplastic. S-Phase Kinase-Associated Proteins / metabolism. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Female. Glucuronidase / metabolism. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Kaplan-Meier Estimate. Male. Middle Aged. Probability. Prognosis. Survival Analysis. Time Factors. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • [CommentIn] Cancer Biol Ther. 2009 Jan;8(2):159-60 [19029792.001]
  • (PMID = 19029817.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S-Phase Kinase-Associated Proteins; 0 / Tumor Suppressor Protein p53; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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22. Ben-Izhak O, Akrish S, Gan S, Nagler RM: p27 and salivary cancer. Cancer Immunol Immunother; 2009 Mar;58(3):469-73
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  • [Title] p27 and salivary cancer.
  • This study examined p27 expression in a cohort of salivary malignancies (n = 74) for a prolonged period (20 years).
  • Reduction of p27 expression was found to be a most powerful predictor for poor survival and more so when the tumor concurrently expressed high levels of p53, TUNEL and heparanase markers, dramatically dropping the patient survival probability to 0!
  • While no patient whose tumor-staining profile included: p27 > 50%, p53 = 0, TUNEL = 0 and heparanase = 0, died of the disease during the 20-year follow up, the median of survival of the group with p27 <or= 50%, p53 > 0, TUNEL > 0 and heparanase > 0 was only 39 months.
  • Significant p27 reduction also resulted in significantly larger tumor size (T value), higher spread of neck metastasis and extra capsular spread and in more advanced disease (higher stage).
  • Significantly more extensive therapy applied to patients with salivary reduced-p27 tumors could not prevent the rise in mortality rate, questioning the justification for extensive therapy which is naturally accompanied by higher morbidity.
  • Additional therapeutic tools for fighting salivary cancer, possibly based on the new understanding of the p27, p53, TUNEL and heparanase carcinogenic network, are necessary.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Gene Expression Regulation, Neoplastic. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Aged. Female. Glucuronidase / metabolism. Humans. In Situ Nick-End Labeling. Male. Middle Aged. Neoplasm Metastasis. Salivary Glands / metabolism. Time Factors. Treatment Outcome. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18663445.001).
  • [ISSN] 1432-0851
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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23. Nagler RM, Ben-Izhak O, Ostrovsky D, Golz A, Hershko DD: The expression and prognostic significance of Cks1 in salivary cancer. Cancer Invest; 2009 Jun;27(5):512-20
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  • [Title] The expression and prognostic significance of Cks1 in salivary cancer.
  • Cks1 is an essential factor in facilitating Skp2-dependent degradation of p27, but its role in salivary malignancies is unknown.
  • Expression of cyclin-dependent kinase subunit 1 (Cks1) was examined in 64 salivary malignancies, compared with p27, S-phase kinase protein 2 (Skp2), Ki-67, p53, and TDT-mediated dutp-biotin nick end labeling (TUNEL) expression, and with THE patient's clinical and pathological parameters.
  • Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer.
  • [MeSH-major] Carrier Proteins / metabolism. Cyclin-Dependent Kinases / metabolism. Salivary Gland Neoplasms / enzymology
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / secondary. Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. CDC2-CDC28 Kinases. Carcinoma, Acinar Cell / enzymology. Carcinoma, Acinar Cell / secondary. Carcinoma, Mucoepidermoid / enzymology. Carcinoma, Mucoepidermoid / secondary. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / secondary. Female. Humans. Immunoenzyme Techniques. In Situ Nick-End Labeling. Ki-67 Antigen / metabolism. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Proliferating Cell Nuclear Antigen / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Survival Rate. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 19296297.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKS1B protein, human; 0 / Carrier Proteins; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / S-Phase Kinase-Associated Proteins; 0 / Tumor Suppressor Protein p53; 0 / p27 antigen; EC 2.7.11.22 / CDC2-CDC28 Kinases; EC 2.7.11.22 / Cyclin-Dependent Kinases
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24. Ben-Izhak O, Laster Z, Araidy S, Nagler RM: TUNEL - an efficient prognosis predictor of salivary malignancies. Br J Cancer; 2007 Apr 10;96(7):1101-6
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  • [Title] TUNEL - an efficient prognosis predictor of salivary malignancies.
  • Biological markers are necessary for predicting prognosis of salivary malignancies and better understanding the pathogenesis of salivary cancer.
  • We analysed terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine-triphosphate (dUTP)-biotin nick-end labelling (TUNEL), p53 and Ki67 expression in 66 patients with malignant salivary tumours by immonohistochemistry, and correlated the data with survival, disease-free survival, tumour grade, stage, and local and distant metastasis.
  • TUNEL efficiently predicted poor prognosis in salivary malignancies.
  • The correlation between TUNEL, p53 and Ki67 staining and survival probabilities, and the pathological grade, stage and metastasis spread of salivary malignancies makes this a highly effective tool in patient follow-up and prognosis.
  • [MeSH-major] Apoptosis. In Situ Nick-End Labeling. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Female. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Predictive Value of Tests. Prognosis. Survival Rate. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17325701.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2360125
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25. Ben-Izhak O, Laster Z, Akrish S, Muska E, Gan S, Nagler RM: The salivary tip of the p53 mutagenesis iceberg: novel insights. Cancer Biomark; 2009;5(1):23-31
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  • [Title] The salivary tip of the p53 mutagenesis iceberg: novel insights.
  • Salivary malignancies are rare, heterogeneous, unpredictable in their clinical behavior and seldom studied.
  • This study focused on examining the expression of mutated p53, the most prevalent mutated gene related to human cancer, in a rather large cohort of salivary malignancies (n = 70) and for a prolonged period (20 years).
  • P53 was found to be a most powerful predictor for poor survival and more so when the tumor concurrently expressed TUNEL and heparanase markers, dramatically dropping the survival probability of the patients to 0!
  • These findings support mutated p53 as a prognostic predictor and a pivotal player in salivary carcinogenesis.
  • Significantly more extensive therapy applied to salivary p53-positive patients did not improve mortality rate, questioning the justification for such extensive therapy and emphasizing the need to understand p53, TUNEL and heparanase biological pathways and develop additional therapeutic tools for fighting salivary cancer.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Mutagenesis. Mutation / genetics. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis. Female. Gene Expression Regulation, Neoplastic. Glucuronidase / metabolism. Humans. Immunoenzyme Techniques. In Situ Nick-End Labeling. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • (PMID = 19242059.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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26. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M: Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg; 2010 Sep;68(9):2092-8
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  • [Title] Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma).
  • PURPOSE: Of all benign salivary gland tumors of the parotid gland, pleomorphic adenoma (mixed tumor) is the most common.
  • It accounts for 60% to 70% of all benign tumors of the parotid gland.
  • This neoplasm arises in patients in the fourth to sixth decade of life, with a female predominance.
  • PATIENTS AND METHODS: We reviewed 48 patients who underwent excision of pleomorphic adenoma of the parotid gland between 1996 and 2005 at Rambam Medical Center: 18 were treated surgically with the classical superficial parotidectomy (SP) technique, using an anterograde approach, and 30 were treated with retrograde partial superficial parotidectomy (PSP).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20728030.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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27. Gallego L, Junquera L, Fresno MF: Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Apr;107(4):555-8

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  • [Title] Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis.
  • Nonsebaceous lymphadenoma (NSL) is an unusual benign salivary gland tumor characterized by a predominant lymphoid background, dense lymphoid infiltrate, and absence of sebaceous differentiation.
  • We report an additional case of NSL arising in the parotid gland in 58-year-old female patient.
  • The extensive immunohistochemical investigation of the tumor revealed the presence of both luminal and myoepithelial cells.
  • The tumor was considered as being DNA diploid.

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  • (PMID = 19201224.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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28. Yang S, Chen X, Wang L, Zhang J: Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation. Virchows Arch; 2007 May;450(5):595-9
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  • [Title] Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation.
  • Non-sebaceous lymphadenoma (NSL) is a rare, recently described, benign salivary gland tumor characterized by a dense lymphoid infiltrate and absence of sebaceous differentiation.
  • The patient was a 50-year-old woman presenting with a slowly growing painless mass in the right parotid gland.
  • The tumor was encapsulated and measured 3 x 2 x 2 cm.
  • Microscopically, the tumor comprised islands of epithelial cells with centrally located duct-like structures within a dense lymphoid stroma.
  • Immunohistochemically, the tumor regularly expressed CKs 7, 8/18, and 19, which are typical for columnar differentiation and CKs 17 and 5/6, which are most typically expressed in basal cells of complex epithelia.
  • [MeSH-major] Lymphoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Keratins / analysis. Middle Aged. Treatment Outcome

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  • (PMID = 17431672.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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29. Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tal T, Jarus-Hakak A, Duvdevani S, Cardis E, Wolf M: Smoking and risk of parotid gland tumors: a nationwide case-control study. Cancer; 2008 May 1;112(9):1974-82
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  • [Title] Smoking and risk of parotid gland tumors: a nationwide case-control study.
  • BACKGROUND: Because existing data regarding the relation between smoking and salivary gland tumors are sparse, tobacco is currently not classified as a salivary gland carcinogen.
  • The objective of the current study was to assess the association between smoking and benign and malignant parotid gland tumors (PGTs) in a nationwide study.
  • Analysis by histologic type indicated remarkably high risks for Warthin tumor (OR for ever cigarette smokers: 15.3; 95% CI, 6.1-38.5).
  • CONCLUSIONS: Smoking plays an important role in the development of Warthin tumor.

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  • [ErratumIn] Cancer. 2008 Aug 1;113(3):662-3
  • (PMID = 18361448.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Azevedo LR, Dos Santos JN, De Lima AA, Machado MA, Grégio AM: Canalicular adenoma presenting as an asymptomatic swelling of the upper lip: a case report. J Contemp Dent Pract; 2008;9(1):91-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: CA is an uncommon benign salivary gland tumor occurring almost exclusively in the intraoral glands.
  • This tumor has often been referred to as a variant of the basal cell adenoma.
  • However, the World Health Organization's latest histological classification of salivary gland tumors recognizes it as a separate entity under the broader heading of monomorphic adenoma, which is not related to any of the subtypes of basal cell adenomas.
  • Microscopic examination confirmed the final diagnosis of CA.
  • The patient is currently free of disease 54 months after surgical excision of the tumor.
  • SUMMARY: Local excision of symptomatic nodules seems to be sufficient to manage patients with multifocal CA.10 But, unlike other benign tumors, CA may need a longer follow-up due to its tendency towards multifocal occurrence and late recurrence.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 18176654.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • Human Herpes Virus 8 (HHV-8) is the etiologic agent for all forms of Kaposi's sarcoma (KS), and HHV-8 DNA is present in saliva, suggesting that non-sexual transmission is associated with latent infection of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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32. Minicucci EM, de Campos EB, Weber SA, Domingues MA, Ribeiro DA: Basal cell adenoma of the upper lip from minor salivary gland origin. Eur J Dent; 2008 Jul;2(3):213-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the upper lip from minor salivary gland origin.
  • Basal cell adenoma is an uncommon benign salivary gland neoplasm, presenting isomorphic basaloid cells with a prominent basal cell layer.
  • Taking into account that basal cell adenomas represent 1% of all salivary gland tumors, being the majority of cases in the parotid glands, the goal of this paper is to report a case of basal cell adenoma of the upper lip arising from minor salivary gland.

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  • [Cites] Int J Oral Maxillofac Surg. 2005 Jul;34(5):533-6 [16053874.001]
  • [Cites] J Oral Maxillofac Surg. 2005 Jun;63(6):805-10 [15944978.001]
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  • (PMID = 19212550.001).
  • [ISSN] 1305-7456
  • [Journal-full-title] European journal of dentistry
  • [ISO-abbreviation] Eur J Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC2635906
  • [Keywords] NOTNLM ; Basal cell adenoma / Immunohistochemistry / Minor salivary gland
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33. Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP: Salivary gland pleomorphic adenoma. Am J Clin Oncol; 2008 Feb;31(1):95-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland pleomorphic adenoma.
  • We discuss the optimal treatment and outcomes for pleomorphic adenoma of the salivary glands by reviewing the pertinent literature.
  • Pleomorphic adenoma is the most common benign salivary gland neoplasm.
  • It is found mostly in the parotid gland in middle-aged women.
  • Local control rates after RT for microscopic and gross residual tumor are approximately 80% to 85% and 40% to 60%, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Neoplasm Recurrence, Local / diagnosis. Salivary Gland Neoplasms / therapy

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  • (PMID = 18376235.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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34. Behzatoglu K, Bahadir B, Huq GE, Kaplan HH: Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review. Diagn Cytopathol; 2005 Jun;32(6):367-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review.
  • Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature.
  • To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA.
  • Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Male. Parotid Gland / blood supply. Parotid Gland / pathology

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  • (PMID = 15880698.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S: Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 May;107(5):e34-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study.
  • Intraductal papilloma is a rare benign salivary gland tumor.
  • This lesion is commonly observed in the duct of the minor salivary gland, predominantly in lip and buccal mucosa, but the case in the sublingual region is quite rare.
  • This report shows a first case of intraductal papilloma developed in minor salivary gland of sublingual region.
  • The excised specimen was histologically diagnosed as intraductal papilloma of minor salivary gland, according to the microscopic finding of the papillary growth of ductal epithelium into the ductal space with fibrovascular core.
  • Immunohistochemical study showed the tumor cells originated from ductal luminal cells because of positive Cytokeratin 18 and 7 staining in both types of cells.
  • [MeSH-major] Papilloma / pathology. Salivary Gland Neoplasms / pathology. Sublingual Gland / pathology

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  • [ErratumIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):475. Tomonao, Aikawa [corrected to Aikawa, Tomonao]
  • (PMID = 19426904.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Keratin-7
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36. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma is a benign sweat gland tumor.
  • This lesion is electively located in the craniofacial area, made of a subcutaneous painless tumor measuring from 0.5 to 3 cm.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • The best treatment remains surgical allowing a histological diagnosis with a control of the lesion edges.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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37. Doğan S, Can IH, Unlü I, Süngü N, Gönültaş MA, Samim EE: Sialolipoma of the parotid gland. J Craniofac Surg; 2009 May;20(3):847-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sialolipoma of the parotid gland.
  • The clinical impression was that of a benign salivary gland tumor.
  • The tumor was situated in the superficial lobe of the gland, and a superficial parotidectomy was performed, with preservation of the facial nerve.
  • Histopathologic examination results revealed a sialolipoma of the parotid gland and a lesion that consisted of both mature adipose tissue and glandular elements.
  • Sialolipomas share similar clinical features with conventional lipomas of the salivary glands.
  • Preoperative diagnosis is generally difficult, and computed tomographic scanning is useful in defining these benign parotid gland masses.
  • Superficial parotidectomy is the usual surgical treatment for parotid gland superficial lobe lipomas, with near-total absence of recurrence.
  • [MeSH-major] Lipoma / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Humans. Male. Parotid Gland / pathology

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  • (PMID = 19390452.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Sit KY, Chui WH, Wang E, Chiu SW: Multiple pulmonary metastases from benign pleomorphic adenoma. Asian Cardiovasc Thorac Ann; 2008 Jan;16(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple pulmonary metastases from benign pleomorphic adenoma.
  • Metastasizing pleomorphic adenoma is a rare condition of metastasis from a histologically benign salivary gland tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Incidental Findings. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Salivary Gland Neoplasms / pathology

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  • (PMID = 18245710.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Manor E, Sion-Vardy N, Bodner L: Cytogenetic and fluorescence in situ hybridization analysis of a basal cell adenocarcinoma of the mandible. Cancer Genet Cytogenet; 2006 Apr 15;166(2):186-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Basal cell adenocarcinoma (BCAC) of the salivary glands is rare.
  • Distant metastasis to the mandible from a salivary gland tumor is also considered rare.
  • An 80-year-old female with primary BCAC of the parotid salivary gland underwent parotidectomy and chemotherapy.
  • The characteristic histologic architecture of BCAC found in the mandible was similar to that of the earlier findings of the tumor in the parotid gland.
  • A paraffin-embedded sample of the primary tumor was also examined by FISH.
  • Trisomy 4 was also found in the paraffin-embedded samples of the primary parotid tumor.

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  • (PMID = 16631478.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Hammami B, Dhouib H, Sallemi M, Ben Hmida A, Ben Mahfoudh K, Daoud J, Ghorbel A: [Acinic cell carcinoma of the nasal septum]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):88-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The surgical treatment was endonasal tumor resection.
  • It is usually located at the salivary gland level.
  • The prognosis is related to tumor extension and quality of resection.

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  • (PMID = 19942241.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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41. Farah-Klibi F, Ferchiou M, Kourda J, El Amine O, Ferjaoui M, Ben Jilani S, Zermani R: [Parotid basal cell adenoma of membranous type]. Tunis Med; 2009 Feb;87(2):149-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adenome a cellules basales de type membraneux de la parotide.
  • INTRODUCTION: Basal cell adenoma (BCA) is a rare benign neoplasm characterized by the basaloid appearance of the tumour cells and the lack of myxo-chondroid stromal component present in pleomorphic adenoma.
  • So the diagnosis of metastatic malignant salivary gland tumor was suspected.
  • CONCLUSION: The BCA is a benign tumor located generally in the parotid gland.
  • When the malignancy is suspected, like in our case, this tumor must be differentiated from the basal cell adenocarcinoma using histological criteria.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis. Sarcoidosis / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Mediastinum / radiography. Treatment Outcome

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  • (PMID = 19522450.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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42. Uğuz MZ, Onal K, Demiray U, Ekinci N: Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1377-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is the most common benign salivary gland tumor.
  • Although the major salivary glands are the most common sites of its origin, it can also occur in the minor salivary glands of the oral cavity and rarely in the neck, ear, nasal cavity and larynx.
  • We report a rare case of intranasal pleomorphic adenoma arising from lateral nasal wall and discuss the clinical presentation, diagnosis and treatment approaches with the review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nasal Cavity / pathology. Nasal Septum / pathology. Nose Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Zygoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17549505.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Chahwala Q, Siddaraju N, Singh N, Goneppanavar M, Basu D: Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case. Acta Cytol; 2009 Jul-Aug;53(4):437-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case.
  • BACKGROUND: Oncocytic lipoadenoma is an uncommon benign salivary gland tumor.
  • CASE: A 50-year-old woman presented with a slow-growing swelling in the left parotid region that was clinically interpreted as a soft tissue tumor, with a differential of neurofibroma/lipoma.
  • The adipose tissue background of the cytologic smears was ignored as material derived from the normal fat tissue; based on the oncocytic population of cells, a diagnosis of oncocytoma was considered.
  • However, histopathologic examination showed it to be an oncocytic lipoadenoma, a tumor we were unaware of at the time of cytodiagnosis.
  • CONCLUSION: Both cytopathologists and histopathologists need to be aware of oncocytic lipoadenoma of the salivary gland in order to diagnose it precisely.
  • The clinicocytopathologic correlation highlighted in our case will be useful for cytopathologists in preoperative interpretation and diagnosis.

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  • (PMID = 19697732.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Gurey LE, Brook CD, Parnes SM: Pleomorphic adenoma of the infratemporal fossa: case report and literature review. Laryngoscope; 2010;120 Suppl 4:S151
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To describe an unusual location for a common benign salivary gland neoplasm.
  • RESULTS: Pleomorphic adenoma has been reported to arise in such diverse locations as the nasal septum, main stem bronchus, trachea, lacrimal gland and external auditory canal.
  • Diagnosis and approach to this region is difficult considering its concealed location.

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  • (PMID = 21225749.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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45. Cohen D, Bhattacharyya I: Case of the month. Canalicular adenoma (benign salivary gland tumor). Todays FDA; 2008 Jun;20(6):13-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of the month. Canalicular adenoma (benign salivary gland tumor).
  • [MeSH-major] Adenoma / diagnosis. Lip Neoplasms / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 18700293.001).
  • [ISSN] 1048-5317
  • [Journal-full-title] Today's FDA : official monthly journal of the Florida Dental Association
  • [ISO-abbreviation] Todays FDA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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