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1. Rao R, Shenoi SD: Acrokeratosis paraneoplastica (Bazex syndrome): an atypical presentation. Dermatol Online J; 2004;10(1):21
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  • A complete physical examination revealed the presence of blood in the stool, and sigmoidoscopy showed an ulcerative growth at the rectosigmoid junction.
  • [MeSH-major] Adenocarcinoma / complications. Foot Dermatoses / etiology. Hand Dermatoses / etiology. Neoplasms, Unknown Primary / complications. Paraneoplastic Syndromes / etiology. Rectal Neoplasms / complications. Sigmoid Neoplasms / complications
  • [MeSH-minor] Antifungal Agents / therapeutic use. Fluconazole / therapeutic use. Humans. Hyperpigmentation / etiology. Male. Middle Aged. Occult Blood. Onychomycosis / complications. Onychomycosis / drug therapy. Pruritus / etiology. Sigmoidoscopy

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  • (PMID = 15347503.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 8VZV102JFY / Fluconazole
  • [Number-of-references] 8
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3. Clemente G, Chiarla C, Giovannini I, De Rose AM, Astone A, Barone C, Nuzzo G: Gas in portal circulation and pneumatosis cystoides intestinalis during chemotherapy for advanced rectal cancer. Curr Med Res Opin; 2010 Mar;26(3):707-11
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  • We describe a patient with acute abdominal symptoms and evidence of PCI with PBG under cetuximab, oxaliplatin, tegafur-uracil and folinic acid chemotherapy for metastatic adenocarcinoma of the rectosigmoid junction.
  • The exam of the abdomen did not suggest major problems requiring emergency surgery, and antibiotic treatment with close monitoring were performed, followed by rapid improvement.
  • It provides an example of the challenges involved in the management of this type of patient.
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Humanized. Cetuximab. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. Rectal Neoplasms / drug therapy. Rectal Neoplasms / pathology. Tegafur / administration & dosage. Tegafur / adverse effects

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  • (PMID = 20078321.001).
  • [ISSN] 1473-4877
  • [Journal-full-title] Current medical research and opinion
  • [ISO-abbreviation] Curr Med Res Opin
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Gases; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 1548R74NSZ / Tegafur; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin
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4. Sahin M, Erikoglu M, Ozer S, Tekin A, Boz S, Gölcük M, Avunduk MC, Aköz M: Determination of operation time in colorectal diseases: preoperative chemotherapy application. J Surg Res; 2005 Apr;124(2):209-15
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  • Twelve of them were placed in the control group (Group I), with no further drug administration.
  • At the end of the sixth cure, 12 rats from the control (Group I), sham (Group II), and chemotherapy groups (Group III) were operated on, and an intestinal transsection was applied to the rectosigmoid junction, followed by one-by-one anastomosis using 5/0 vicryl.
  • Other groups (Groups IV-VI) with chemotherapy treatment were operated on at 1-week intervals and subjected to the same procedure.
  • [MeSH-major] Antimetabolites, Antineoplastic / pharmacology. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / surgery. Fluorouracil / pharmacology. Wound Healing / drug effects
  • [MeSH-minor] Abdominal Wall / pathology. Animals. Combined Modality Therapy. Female. Fibroblasts / pathology. Hydroxyproline / metabolism. Leukocyte Count. Preoperative Care. Rats. Rats, Wistar. Serum Albumin / metabolism. Time Factors

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  • (PMID = 15820250.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Serum Albumin; RMB44WO89X / Hydroxyproline; U3P01618RT / Fluorouracil
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5. Drewes AM, Petersen P, Rössel P, Gao C, Hansen JB, Arendt-Nielsen L: Sensitivity and distensibility of the rectum and sigmoid colon in patients with irritable bowel syndrome. Scand J Gastroenterol; 2001 Aug;36(8):827-32
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  • [Title] Sensitivity and distensibility of the rectum and sigmoid colon in patients with irritable bowel syndrome.
  • BACKGROUND: Hyperalgesia to visceral stimuli is a biological marker of the irritable bowel syndrome (IBS).
  • In the current study, we investigated the sensation of the gut to electrical stimuli as well as the distensibility of the rectum and sigmoid colon in IBS patients and a control group.
  • The pain threshold to electrical stimuli at the rectosigmoid junction was determined with bipolar electrodes integrated on the biopsy forceps for the endoscope.
  • Subsequently, controlled distensions of the sigmoid colon and rectum were performed with a balloon integrated on a probe for impedance planimetry, providing the possibility to measure the cross-sectional area (CSA), wall tension and strain to different pressures together with the sensation ratings.
  • RESULTS: The pain detection thresholds to electrical stimuli at the rectosigmoid junction were 12.5 (range 7-39) mA in controls and 7.5 (range 0.75-12) mA in IBS patients (P = 0.03).
  • The calculated pressures at the pain detection threshold in the sigmoid colon were lower in the IBS patients (31.5 (range 5-58) versus 5 cm (range 5-25) water; P = 0.03), otherwise no differences were seen in sensation rating to the different distension pressures.
  • The CSA was slightly higher in controls to the different pressures, whereas no differences between the groups were seen in strain and tension of the rectum and sigmoid colon.
  • Treatment of pain in IBS should therefore be based on drugs with documented action on the nociceptive pathways in the central nervous system.
  • [MeSH-major] Colon, Sigmoid / physiopathology. Colonic Diseases, Functional / diagnosis. Hyperalgesia / diagnosis. Pain / physiopathology. Rectum / physiopathology. Visceral Afferents / physiopathology


6. Kim S, Martin C, Galanko J, Woosley JT, Schroeder JC, Keku TO, Satia JA, Halabi S, Sandler RS: Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. Am J Epidemiol; 2008 Dec 1;168(11):1292-300
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  • [Title] Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans.
  • Despite the belief that the etiology of and risk factors for rectal cancer might differ from those for colon cancer, relatively few studies have examined rectal cancer in relation to use of nonsteroidal antiinflammatory drugs (NSAIDs).
  • The authors evaluated the association between NSAIDs and distal large bowel cancer in African Americans and whites, using data from a population-based case-control study of 1,057 incident cases of adenocarcinoma of the sigmoid colon, rectosigmoid junction, and rectum and 1,019 controls from North Carolina (2001-2006).
  • In addition, the strength of the association with NSAIDs varied by tumor location, suggesting more potent effects for rectal and rectosigmoid cancers than for sigmoid cancer.
  • The chemopreventive potential of NSAIDs might differ by population and by tumor characteristics.

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  • (PMID = 18945689.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK034987; United States / NCI NIH HHS / CA / R01 CA066635; United States / NIDDK NIH HHS / DK / P30 DK34987; United States / NCI NIH HHS / CA / R01 CA 66635
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors
  • [Other-IDs] NLM/ PMC2727267
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7. Ablassmaier B, Hartmann J: [A case of severe gangrenous ischemic colitis following nonsteroidal anti-inflammatory drug intake]. Zentralbl Chir; 2004 Dec;129(6):510-2
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  • [Title] [A case of severe gangrenous ischemic colitis following nonsteroidal anti-inflammatory drug intake].
  • Laparotomy revealed partial necrosis of the colonic wall from the cecum to the rectosigmoid junction.
  • The patient reported medication with diclofenac for rheumatoid arthritis.
  • The most probable diagnosis was NSAID-induced colitis.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Colitis, Ischemic / chemically induced. Diclofenac / adverse effects
  • [MeSH-minor] Arthritis, Rheumatoid / drug therapy. Colectomy. Colon / pathology. Female. Follow-Up Studies. Humans. Laparotomy. Middle Aged. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 15616917.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 144O8QL0L1 / Diclofenac
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8. Liu SH, Liu YF, Liou SH, Lin YL, Hsiao YC, Chen CC, Li CY, Wu TN: Mortality and cancer incidence among physicians of traditional Chinese medicine: a 20-year national follow-up study. Occup Environ Med; 2010 Mar;67(3):166-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mortality and cancer incidence among physicians of traditional Chinese medicine: a 20-year national follow-up study.
  • OBJECTIVE: To study the risks of mortality and cancer incidence in physicians of traditional Chinese medicine (TCM) who had frequent exposure to herbal medicine.
  • METHODS: A population-based cohort design was conducted in which a total of 7675 certified physicians of TCM who ever practised between 1985 and 2005 were compared with the age-, sex- and calendar year-specific mortalities and cancer incidence rates of the general population of Taiwan.
  • The study cohort also had a significantly reduced SIR (80, 95% CI 71 to 90) for all cancers, and for neoplasm of rectum, rectosigmoid junction, and anus (SIR=45), female breast (SIR=30) and cervix uteri (SIR=10).
  • On the other hand, we noted that physicians of TCM suffered from a significantly increased SIR for neoplasm of liver and intrahepatic bile ducts (SIR=151, 95% CI 116 to 192) and of bladder cancer (SIR=259, 95% CI 167 to 382).
  • Nonetheless, reasons truly responsible for significantly increased risks of liver and bladder neoplasm among physicians of TCM warrant further investigations.
  • [MeSH-major] Medicine, Chinese Traditional. Neoplasms / mortality. Occupational Diseases / mortality. Occupational Exposure
  • [MeSH-minor] Adult. Cause of Death. Cohort Studies. Drugs, Chinese Herbal / adverse effects. Female. Follow-Up Studies. Humans. Incidence. Liver Neoplasms / mortality. Male. Middle Aged. Risk Factors. Taiwan / epidemiology. Urinary Bladder Neoplasms / mortality. Young Adult

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  • (PMID = 20223844.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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9. Pais AV, Pereira S, Garg I, Stephen J, Antony M, Inchara YK: Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Lepr Rev; 2004 Jun;75(2):171-6
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  • A 44-year-old female with lepromatous leprosy and a history of adverse reaction to clofazimine 2 years previously, presented with rectosigmoid junction adenocarcinoma.
  • Laparotomy revealed an inoperable tumour with pigmentation of the bowel, serosa and peritoneum.
  • Despite widespread use for many years in the treatment of leprosy, this drug is not known to be carcinogenic and this case provides no evidence for an association or link between its use and the patient's cancer.
  • [MeSH-major] Abdominal Pain / chemically induced. Adenocarcinoma / complications. Clofazimine / adverse effects. Colonic Neoplasms / complications. Histiocytosis / chemically induced. Leprostatic Agents / adverse effects. Leprosy, Lepromatous / complications

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  • (PMID = 15282969.001).
  • [ISSN] 0305-7518
  • [Journal-full-title] Leprosy review
  • [ISO-abbreviation] Lepr Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leprostatic Agents; D959AE5USF / Clofazimine
  • [Number-of-references] 17
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10. Gerson LB, Van Dam J: A prospective randomized trial comparing a virtual reality simulator to bedside teaching for training in sigmoidoscopy. Endoscopy; 2003 Jul;35(7):569-75
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  • MATERIALS AND METHODS: Internal medicine residents were randomly assigned to training exclusively using a virtual reality simulator (group 1) or via bedside teaching (group 2).
  • Each examination was scored from 1 (inability to insert the endoscope beyond the rectum) to 5 (able to complete the entire examination independently in less than 20 min).
  • Participants in group 1 had more difficulty with initial endoscope insertion and negotiation of the rectosigmoid junction (mean score +/- SEM 2.9 +/- 0.2) than those in group 2 (3.8 +/- 0.2) ( P < 0.001).
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Computer Simulation. Education, Medical, Graduate / methods. Sigmoidoscopy. Teaching / methods. User-Computer Interface

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  • [ErratumIn] Endoscopy. 2004 Feb;36(2):185
  • (PMID = 12822091.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
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