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1. Gupta S, Gupta S, Aggarwal K, Jain VK: Becker nevus with vitiligo and lichen planus: Cocktail of dermatoses. N Am J Med Sci; 2010 Jul;2(7):333-5
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  • [Title] Becker nevus with vitiligo and lichen planus: Cocktail of dermatoses.
  • CONTEXT: Becker nevus has been reported to be associated with lichen planus (LP) in isolated case reports in past.
  • The coexistence of lichen planus, vitiligo and Becker nevus has not been reported so far.
  • CASE REPORT: A thirty five years old male presented with lesions of Becker nevus along with vitiligo and Lichen planus coexisting at one place on right side of the chest.
  • Vitiligo and Becker nevus could not be treated.

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  • (PMID = 22558584.001).
  • [ISSN] 1947-2714
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3341642
  • [Keywords] NOTNLM ; Becker nevus / associations / coexistence / dermatoses / lichen planus / vitiligo
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2. Cosendey FE, Martinez NS, Bernhard GA, Dias MF, Azulay DR: Becker nevus syndrome. An Bras Dermatol; 2010 May-Jun;85(3):379-84
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  • [Title] Becker nevus syndrome.
  • Becker nevus syndrome is a phenotype characterized by the fundamental presence of Becker's nevus with ipsilateral hypoplasia of the breast or other skin, skeletal and/or muscular disorders.
  • This syndrome generally originates at birth, intensifies significantly in adolescence and is one of the syndromes that constitute epidermal nevus syndrome.
  • To the best of our knowledge, this is the first case published in the Brazilian literature of Becker nevus syndrome associated with Becker's nevus, ipsilateral breast hypoplasia and scoliosis in a 14-year-old girl.
  • [MeSH-major] Breast / abnormalities. Hamartoma / pathology. Hypertrichosis / pathology. Skin Diseases / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Hyperpigmentation / pathology. Syndrome

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  • (PMID = 20676475.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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3. Grim KD, Wasko CA: Symmetrical bilateral Becker melanosis: A rare presentation. Dermatol Online J; 2009;15(12):1

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  • [Title] Symmetrical bilateral Becker melanosis: A rare presentation.
  • Becker melanosis, also known as Becker nevus, is a relatively common cutaneous hamartoma.
  • As Becker nevi are generally singular in a given individual, there are very few reported cases of multiple or bilateral lesions.
  • We herein report a rare case of bilateral, symmetrical, non-syndromic Becker melanosis and we discuss possible pathogenesis and current treatment options.
  • [MeSH-major] Melanosis / pathology

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  • (PMID = 20040251.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Ro YS, Ko JY: Linear congenital Becker nevus. Cutis; 2005 Feb;75(2):122-4
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  • [Title] Linear congenital Becker nevus.
  • Becker nevus is an acquired disorder that usually manifests in late childhood or adolescence as a hyperpigmented hypertrichotic patch usually located on the upper trunk or proximal upper extremities.
  • Only a few cases of congenital and familial Becker nevus have been described.
  • Although the lesions may have various shapes, they consistently have a geographic or blocklike configuration in an irregular fashion; a linear pattern has rarely been reported.
  • We describe a case of linear congenial Becker nevus following Blaschko line that appeared at birth on the right shoulder, with hypertrichosis developing 4 years later.
  • [MeSH-major] Hyperpigmentation / pathology. Hypertrichosis / diagnosis. Nevus, Intradermal / congenital. Nevus, Intradermal / pathology

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  • (PMID = 15773534.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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5. Baeta IG, Viotti CV, Pereira AC, Costa Júnior SR, Bittencourt FV: Becker's nevus syndrome: case report. An Bras Dermatol; 2010 Sep-Oct;85(5):713-6
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  • [Title] Becker's nevus syndrome: case report.
  • Becker's nevus is a hyperpigmented macula that is predominantly located on the anterior trunk or on the scapular region, frequently associated with hypertrichosis.
  • The association of Becker's nevus with other cutaneous, musculoskeletal or maxillofacial anomalies has been called Becker's nevus syndrome.
  • The histological exam confirmed the clinical hypothesis of Becker's nevus.
  • [MeSH-major] Breast / abnormalities. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 21152801.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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6. Criscione V, Telang GH: Becker nevus with ichthyotic features. Arch Dermatol; 2010 May;146(5):575-7
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  • [Title] Becker nevus with ichthyotic features.
  • [MeSH-major] Ichthyosis / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 20479323.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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7. Fernandes C, Agrawal A, Shreshtha BB, Yogi N, Cherian I: Becker's nevus syndrome with quadriparesis. BMJ Case Rep; 2010;2010
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  • [Title] Becker's nevus syndrome with quadriparesis.
  • Histopathological examination of the skin revealed findings consistent with Becker's nevus.
  • Based on the patient's clinical presentation and investigations, a diagnosis of Becker's nevus syndrome was made.
  • The authors review Becker's nevus syndrome and its clinical manifestations below.
  • [MeSH-major] Nevus / congenital. Nevus / diagnosis. Quadriplegia / congenital. Quadriplegia / diagnosis. Skin Neoplasms / congenital. Skin Neoplasms / diagnosis

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  • [Cites] Arch Dermatol. 1981 Apr;117(4):243 [7212749.001]
  • [Cites] J Am Acad Dermatol. 1984 Feb;10(2 Pt 1):235-8 [6715592.001]
  • [Cites] Arch Dermatol. 1992 Jul;128(7):992-3 [1626973.001]
  • [Cites] Am J Med Genet. 1997 Jan 31;68(3):357-61 [9024572.001]
  • [Cites] Arch Derm Syphilol. 1949 Aug;60(2):155-60 [18133444.001]
  • [Cites] Arch Dermatol. 2007 Dec;143(12):1488-90 [18086996.001]
  • (PMID = 22798308.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Becker Nevus Syndrome
  • [Other-IDs] NLM/ PMC3028056
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8. Kim YJ, Han JH, Kang HY, Lee ES, Kim YC: Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis. J Cutan Pathol; 2008 Dec;35(12):1121-6
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  • [Title] Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis.
  • BACKGROUND: Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous hamartoma that frequently appears in adolescence.
  • [MeSH-major] Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. Receptors, Androgen / biosynthesis. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 18616760.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanins; 0 / Neoplasm Proteins; 0 / Receptors, Androgen; 0 / S100 Proteins
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9. Abbasi N, Fangman WL, Rosenman KS, Schaffer JV: ILVEN-like persistent psoriasiform dermatitis confined to a congenital Becker nevus. Pediatr Dermatol; 2008 May-Jun;25(3):390-1
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  • [Title] ILVEN-like persistent psoriasiform dermatitis confined to a congenital Becker nevus.
  • A 10-year-old boy presented with a 5-year history of an intractably pruritic, recalcitrant psoriasiform plaque in a broad vertical band on the left buttock, with histologic as well as clinical features suggestive of an inflammatory linear verrucous epidermal nevus.
  • This lesion was completely superimposed upon a congenital Becker nevus.
  • We postulate that the restricted distribution and persistence of the psoriasiform plaque reflected an inflammatory response limited to the aberrant clone of cells composing the Becker nevus, a manifestation of cutaneous mosaicism that could be characterized as an "inflammatory Becker nevus. "
  • [MeSH-major] Dermatitis. Hamartoma / congenital. Skin Diseases / congenital
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Nevus / diagnosis. Pruritus / etiology. Psoriasis / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 18577054.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Alhusayen R, Kanigsberg N, Jackson R: Becker nevus on the lower limb: case report and review of the literature. J Cutan Med Surg; 2008 Jan-Feb;12(1):31-4
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  • [Title] Becker nevus on the lower limb: case report and review of the literature.
  • BACKGROUND: Becker nevus is a hamartoma with brown hyperpigmentation and hypertrichosis that usually affects young males.
  • OBJECTIVE: This is a case report of a 38-year-old male with a Becker nevus without hypertrichosis on the lower limb and a review of the literature.
  • RESULTS: Including our case report, 12 cases of Becker nevus on the lower limb were identified in the English literature (8 males and 4 females).
  • CONCLUSION: The presence of Becker nevi on the lower limb is unusual, and hypertrichosis is not always a feature.
  • [MeSH-major] Hamartoma / diagnosis. Hyperpigmentation / diagnosis. Lower Extremity. Skin Diseases / diagnosis

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  • (PMID = 18258146.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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11. Khatami A, Seradj MH, Gorouhi F, Firooz A, Dowlati Y: Giant bilateral becker nevus: a rare presentation. Pediatr Dermatol; 2008 Jan-Feb;25(1):47-51
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  • [Title] Giant bilateral becker nevus: a rare presentation.
  • A clinical diagnosis of Becker nevus was made and confirmed histopathologically.
  • Different clinical features of Becker nevi, associated findings, differential diagnoses, and treatment options are discussed.
  • [MeSH-major] Hamartoma / pathology. Lentigo / pathology. Nevus, Pigmented / pathology. Skin Diseases / pathology

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  • (PMID = 18304153.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ingordo V, Iannazzone SS, Cusano F, Naldi L: Dermoscopic features of congenital melanocytic nevus and Becker nevus in an adult male population: an analysis with a 10-fold magnification. Dermatology; 2006;212(4):354-60
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  • [Title] Dermoscopic features of congenital melanocytic nevus and Becker nevus in an adult male population: an analysis with a 10-fold magnification.
  • BACKGROUND: Dermoscopic features of congenital melanocytic nevi (CMN) have been mostly assessed by high-resolution video-dermoscopy.
  • In some instances, the differential diagnosis between large CMN and Becker nevus (BN) may be difficult.
  • RESULTS: There were 127 male subjects, median age 19 years, with 127 CMN, measuring > or = 1.5 to < or = 19.9 cm in 78% and > or = 20 cm in 22% of cases, and 64 male subjects, median age 19 years, with 64 BN.
  • [MeSH-major] Dermoscopy. Dysplastic Nevus Syndrome / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2006 S. Karger AG, Basel
  • (PMID = 16707885.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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13. Alfaro A, Torrelo A, Hernández A, Zambrano A, Happle R: [Becker nevus syndrome]. Actas Dermosifiliogr; 2007 Nov;98(9):624-6
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  • [Title] [Becker nevus syndrome].
  • [Transliterated title] Síndrome del nevo de Becker.
  • Becker nevus is a hyperpigmented hamartoma with an irregular outline and often hairy.
  • Becker nevus is sometimes associated with other muscular, skeletal, or cutaneous abnormalities such as ipsilateral breast hypoplasia or scoliosis.
  • This characteristic phenotype of Becker nevus associated with unilateral breast hypoplasia or other abnormalities is referred to as Becker nevus syndrome.
  • Although the lesions usually become apparent during adolescence, they are present from birth and represent part of the spectrum of so-called epidermal nevus syndromes.
  • We present 4 cases of Becker nevus syndrome in which Becker nevus was associated with ipsilateral breast hypoplasia and, less consistently, other abnormalities.
  • [MeSH-major] Hamartoma / pathology. Hyperpigmentation / pathology. Skin Diseases / pathology
  • [MeSH-minor] Adolescent. Breast / abnormalities. Child. Humans. Male. Nevus. Syndrome

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  • (PMID = 17961453.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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14. Sciallis GF, Sciallis AP: Becker nevus with an underlying desmoid tumor: a case report and review including Mayo Clinic's experience. Arch Dermatol; 2010 Dec;146(12):1408-12
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  • [Title] Becker nevus with an underlying desmoid tumor: a case report and review including Mayo Clinic's experience.
  • BACKGROUND: Becker nevus is a nevoid melanosis, referred to as Becker nevus syndrome when it is associated with other anomalies.
  • Our objectives were to report the occurrence of a Becker nevus with an underlying desmoid soft-tissue tumor; to review Mayo Clinic's experience with Becker nevi, concentrating on Becker nevi associated with bone, vascular, neural, and other soft-tissue abnormalities; to inform physicians of the Becker nevus syndrome; and finally to alert clinicians to evaluate a Becker nevus with its associations in mind.
  • OBSERVATIONS: A 46-year-old woman had a Becker nevus with an underlying desmoid-type fibromatosis (desmoid tumor) presenting clinically as a "painful dimple" within the nevus.
  • Review of medical records for 1997 through 2006 at Mayo Clinic, Rochester, Minnesota, yielded 52 patients with Becker nevi, 12 of whom had an associated bone, vascular, neural, congenital, or other soft-tissue abnormality, ranging from liposarcoma to an accessory areola.
  • CONCLUSIONS: We add to the literature a unique case of desmoid-type fibromatosis immediately beneath a Becker melanosis, which presented as a painful dimple.
  • We hope to raise awareness that a Becker nevus may be associated with other abnormalities, including an infiltrative soft-tissue tumor.
  • We also emphasize the importance of follow-up, including inspection of not only the surface but also the deep tissues underlying the Becker nevus.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Neoplasms, Multiple Primary / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 21173323.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. de Almeida HL Jr, Duquia RP, Souza PR, Breunig Jde A: Prevalence and characteristics of Becker nevus in Brazilian 18-year-old males. Int J Dermatol; 2010 Jun;49(6):718-20
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  • [Title] Prevalence and characteristics of Becker nevus in Brazilian 18-year-old males.
  • [MeSH-major] Hamartoma / epidemiology. Hyperpigmentation / epidemiology. Skin Diseases / epidemiology
  • [MeSH-minor] Adolescent. Brazil / epidemiology. Humans. Male. Nevus. Prevalence

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  • (PMID = 20618484.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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16. Kiliç A, Kaya I, Gül U, Soylu S, Gönül M, Demiriz M: Becker nevus on face with asymmetrical growth of beard hair. J Eur Acad Dermatol Venereol; 2008 Feb;22(2):246-7
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  • [Title] Becker nevus on face with asymmetrical growth of beard hair.
  • [MeSH-major] Face / pathology. Hair / growth & development. Hamartoma / diagnosis. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Humans. Hyperpigmentation / diagnosis. Hyperpigmentation / pathology. Male

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  • (PMID = 18211427.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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17. Sugarman JL: Epidermal nevus syndromes. Semin Cutan Med Surg; 2007 Dec;26(4):221-30
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  • [Title] Epidermal nevus syndromes.
  • The term "epidermal nevus syndrome" (ENS) has been used to describe the association of epidermal hamartomas and extra-cutaneous abnormalities.
  • Epidermal nevi follow the lines of Blaschko.
  • Several subsets with characteristic features have been delineated including the nevus sebaceous syndrome, Proteus syndrome, CHILD syndrome, Becker nevus syndrome, nevus comedonicus syndrome, and phakomatosis pigmentokeratotica.
  • Epidermal nevi have been associated with benign and malignant neoplasms.
  • [MeSH-major] Hamartoma. Nevus
  • [MeSH-minor] Humans. Keratinocytes / pathology. Mosaicism. Mutation. Nevus, Pigmented / diagnosis. Nevus, Sebaceous of Jadassohn / classification. Nevus, Sebaceous of Jadassohn / diagnosis. Nevus, Sebaceous of Jadassohn / epidemiology. Proteus Syndrome. Skin Neoplasms / epidemiology. Syndrome. Terminology as Topic

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  • (PMID = 18395670.001).
  • [ISSN] 1085-5629
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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18. Schepis C, Lentini M, Failla P, Castiglia L, Fichera M, Romano C: An unusual presentation of Becker Nevus. Eur J Dermatol; 2010 Jul-Aug;20(4):522-3
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  • [Title] An unusual presentation of Becker Nevus.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin Diseases / diagnosis

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  • (PMID = 20406725.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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19. Puri S, Nanda S, Grover C, Batra VV, Garg VK, Reddy BS: Congenital becker nevus with lichen planus. Pediatr Dermatol; 2005 Jul-Aug;22(4):328-30
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  • [Title] Congenital becker nevus with lichen planus.
  • We report an interesting and rare association of congenital Becker nevus with lichen planus occurring in an 11-year-old boy.
  • [MeSH-major] Lichen Planus / complications. Nevus, Pigmented / complications. Skin Neoplasms / complications

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  • (PMID = 16060869.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; ADN79D536H / Clobetasol
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20. Happle R: The group of epidermal nevus syndromes Part I. Well defined phenotypes. J Am Acad Dermatol; 2010 Jul;63(1):1-22; quiz 23-4
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  • [Title] The group of epidermal nevus syndromes Part I. Well defined phenotypes.
  • The epidermal nevus syndromes represent a group of distinct disorders that can be distinguished by the type of associated epidermal nevus and by the criterion of presence or absence of heritability.
  • Well defined syndromes characterized by organoid epidermal nevi include Schimmelpenning syndrome, phacomatosis pigmentokeratotica, nevus comedonicus syndrome, angora hair nevus syndrome, and Becker nevus syndrome.
  • By contrast, the group of syndromes characterized by keratinocytic nevi comprises three phenotypes with a known molecular etiology in the form of CHILD (congenital hemidysplasia with ichthyosiform nevus and limb defects) syndrome, type 2 segmental Cowden disease, and fibroblast growth factor receptor 3 epidermal nevus syndrome (García-Hafner-Happle syndrome), whereas Proteus syndrome is still of unknown origin.
  • From this overview, it is clear that a specific type of these disorders cannot be classified by the name "epidermal nevus syndrome" nor by the terms "organoid nevus syndrome" or "keratinocytic nevus syndrome."
  • LEARNING OBJECTIVES: After completing this learning activity, participants should be able to distinguish nine different epidermal nevus syndromes by their characteristic features, understand the practical significance of avoiding terms like "epidermal nevus syndrome" or "keratinocytic nevus syndrome" to define any specific entity within this group of disorders, and differentiate between nonhereditary traits and those bearing a genetic risk because of either Mendelian or non-Mendelian inheritance.
  • [MeSH-major] Nevus. Skin Neoplasms
  • [MeSH-minor] Child. Child, Preschool. Female. Hamartoma Syndrome, Multiple. Humans. Infant. Infant, Newborn. Male. Neurocutaneous Syndromes. Nevus, Sebaceous of Jadassohn. Phenotype. Proteus Syndrome. Syndrome

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  • [Copyright] Copyright (c) 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20542174.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 288
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21. Tedeschi A, Dall'Oglio F, Micali G, Schwartz RA, Janniger CK: Corrective camouflage in pediatric dermatology. Cutis; 2007 Feb;79(2):110-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Many dermatologic diseases, including vitiligo and other pigmentary disorders, vascular malformations, acne, and disfiguring scars from surgery or trauma, can be distressing to pediatric patients and can cause psychological alterations such as depression, loss of self-esteem, deterioration of quality of life, emotional distress, and, in some cases, body dysmorphic disorder.
  • Six patients had acne vulgaris; 4 had vitiligo; 2 had Becker nevus; and 1 each had striae distensae, allergic contact dermatitis. and postsurgical scarring.

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  • (PMID = 17388210.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics
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22. Ingordo V, Gentile C, Iannazzone SS, Cusano F, Naldi L: The 'EpiEnlist' project: a dermo-epidemiologic study on a representative sample of young Italian males. Prevalence of selected pigmentary lesions. J Eur Acad Dermatol Venereol; 2007 Sep;21(8):1091-6
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  • All the subjects showing skin lesions evocative of neurofibromatosis (NF), congenital melanocytic nevus (CMN), Becker nevus (BN), and vitiligo were referred to the Department of Dermatology of the Italian Navy Hospital for confirming the diagnosis.

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  • (PMID = 17714131.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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23. Monroe JR: An enlarging lesion on the knee of a teenager. Becker nevus. JAAPA; 2009 Apr;22(4):14
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  • [Title] An enlarging lesion on the knee of a teenager. Becker nevus.
  • [MeSH-major] Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19452816.001).
  • [ISSN] 1547-1896
  • [Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants
  • [ISO-abbreviation] JAAPA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Rodríguez-Díaz E, Alvarez-Cuesta CC, Blanco S, Galache C, Hidalgo Y: [Becker's nevus associated with epidermal nevus: another example of twin spotting?]. Actas Dermosifiliogr; 2006 Apr;97(3):200-2
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  • [Title] [Becker's nevus associated with epidermal nevus: another example of twin spotting?].
  • [Transliterated title] Nevo de Becker asociado a nevo epidérmico: 'un ejemplo más de "manchas gemelas"?
  • Linear epidermal nevi are believed to be caused by an autosomal dominant lethal mutation that can only be expressed by mosaicism.
  • Becker's nevus can be explained by paradominant inheritance which is only manifested clinically by an acquired loss of heterozygosity.
  • We present the case of a 16-year-old female with an epidermal nevus located on the left side of the neck, and also a Becker's nevus located on the ipsilateral shoulder.
  • [MeSH-major] Hamartoma / genetics. Head and Neck Neoplasms / genetics. Mosaicism. Nevus, Pigmented / genetics. Skin Diseases / genetics. Skin Neoplasms / genetics


25. Di Lernia V: Linear and whorled hypermelanosis. Pediatr Dermatol; 2007 May-Jun;24(3):205-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear and whorled hypermelanosis.
  • Linear and whorled nevoid hypermelanosis is a sporadic pigmentary anomaly occurring within the first weeks of life, characterized clinically by swirls and streaks of macular hyperpigmentation following the lines of Blaschko.
  • Histologically it shows only epidermal melanosis.
  • Progressive cribriform and zosteriform hyperpigmentation is considered to be the localized variant of linear and whorled nevoid hypermelanosis.
  • We report a retrospective study on 16 children referred consecutively over a 10-year period for evaluation of segmental, linear or swirled hyperpigmentation distributed along the lines of Blashko, consistent with a diagnosis of linear and whorled nevoid hypermelanosis.
  • Associated abnormalities were found only in one out of six patients with the diffuse form (linear and whorled nevoid hypermelanosis-type) and in none of the remaining 10 children presenting the unilateral form (progressive cribriform and zosteriform hyperpigmentation-type).
  • Linear and whorled nevoid hypermelanosis and hypomelanosis of Ito should be not considered single entities, but be rather grouped as a heterogeneous collection of nonspecific pigmentary disorders caused by genetic mosaicism.
  • [MeSH-major] Hyperpigmentation / pathology

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  • (PMID = 17542865.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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26. Grande Sarpa H, Harris R, Hansen CD, Callis Duffin KP, Florell SR, Hadley ML: Androgen receptor expression patterns in Becker's nevi: an immunohistochemical study. J Am Acad Dermatol; 2008 Nov;59(5):834-8
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  • [Title] Androgen receptor expression patterns in Becker's nevi: an immunohistochemical study.
  • BACKGROUND: Becker's nevus (BN) is a hyperpigmented patch that traditionally presents on the upper torso in adolescent males.
  • METHODS: Biopsy specimens from Becker's nevi in 3 women and 3 men as well as normal skin in the 3 female subjects were stained with AR antibody, and the level of expression in various cutaneous structures was measured.
  • RESULTS: ARs were increased in dermal fibroblasts in Becker's nevi compared to that found in normal skin.
  • [MeSH-major] Nevus, Pigmented / metabolism. Receptors, Androgen / biosynthesis

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  • (PMID = 19119099.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen
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27. Happle R: The group of epidermal nevus syndromes Part II. Less well defined phenotypes. J Am Acad Dermatol; 2010 Jul;63(1):25-30; quiz 31-2
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  • [Title] The group of epidermal nevus syndromes Part II. Less well defined phenotypes.
  • In addition to the well established epidermal nevus syndromes, such as Schimmelpenning, Becker, Proteus, CHILD, or nevus comedonicus syndromes, the group of less well defined phenotypes associated with epidermal nevi presently includes nevus trichilemmocysticus syndrome, didymosis aplasticosebacea, SCALP syndrome (sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid,and pigmented nevus), Gobello syndrome, Bäfverstedt syndrome, NEVADA syndrome (nevus epidermicus verrucosus with angio-dysplasia and aneurysms), and CLOVE syndrome (congenital lipomatous overgrowth, vascular malformations, and epidermal nevus).
  • LEARNING OBJECTIVES: After completing this learning activity, participants should be able to understand why the list of distinct epidermal nevus syndromes can thus far not be regarded as being complete; why clinicians, when seeing a patient with an epidermal nevus syndrome that is difficult to categorize, should bear in mind the group of less well defined epidermal nevus syndromes; and how practical dermatologists can help recognize rare forms of epidermal nevus syndromes and categorize them appropriately.
  • [MeSH-major] Nevus. Skin Neoplasms

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  • [Copyright] Copyright (c) 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20542175.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Afsar FS, Aktas S, Ortac R: Becker's naevus and segmental naevus depigmentosus: an example of twin spotting? Australas J Dermatol; 2007 Nov;48(4):224-6
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  • [Title] Becker's naevus and segmental naevus depigmentosus: an example of twin spotting?
  • A 12-year-old girl presented with a 1-year history of a Becker's naevus involving the right posterior thigh and gluteal area.
  • In addition, three hypopigmented macules of naevus depigmentosus distributed in a segmental pattern on the medial aspect of the right posterior thigh had been present since birth.
  • [MeSH-major] Hypopigmentation / pathology. Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Hyperpigmentation / genetics. Immunohistochemistry. Melanocytes / pathology. Mosaicism

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  • (PMID = 17956480.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Scheller K, Scheller C, Becker S, Holzhausen HJ, Schubert J: Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: a case report and review of literature. J Craniomaxillofac Surg; 2010 Dec;38(8):601-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: a case report and review of literature.
  • A case of cervical lymph node infiltration by a benign cellular blue nevus (CBN) and a 27-year disease history is presented.
  • Dermal dendritic melanocytes and pigmented spindle cells presented no histological evidence of malignancy (CD34-, desmin-, PanCy-, HMB-45+, anti-S-100+, Bcl-2+, MART-1+, focally expression of melan A, 1% Ki-67+ of the tumour cell nucleoli).
  • The differentiation of the benign blue nevus (BN) from a malignant blue nevus (MBN) and a malignant melanoma (MM) is still a challenge.
  • [MeSH-major] Lymph Nodes / pathology. Nevus, Blue / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20223677.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
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30. Choi JE, Kim JW, Seo SH, Son SW, Ahn HH, Kye YC: Treatment of Becker's nevi with a long-pulse alexandrite laser. Dermatol Surg; 2009 Jul;35(7):1105-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of Becker's nevi with a long-pulse alexandrite laser.
  • BACKGROUND: Becker's nevus (BN) can be a distressing cosmetic handicap for patients and a treatment challenge for physicians.
  • [MeSH-major] Lasers, Solid-State / therapeutic use. Low-Level Light Therapy. Nevus, Pigmented / radiotherapy

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  • (PMID = 19438687.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Trelles MA, Allones I, Moreno-Arias GA, Vélez M: Becker's naevus: a comparative study between erbium: YAG and Q-switched neodymium:YAG; clinical and histopathological findings. Br J Dermatol; 2005 Feb;152(2):308-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Becker's naevus: a comparative study between erbium: YAG and Q-switched neodymium:YAG; clinical and histopathological findings.
  • BACKGROUND: Becker's naevus (BN) may represent a distressing cosmetic handicap and a challenging issue regarding treatment.
  • However, in terms of pigment removal, one pass with Er:YAG is a superior technique to three treatment sessions with the Nd:YAG.
  • [MeSH-major] Laser Coagulation / methods. Laser Therapy. Nevus, Pigmented / surgery. Skin Neoplasms / surgery

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  • (PMID = 15727644.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
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32. Rasi A, Taghizadeh A, Yaghmaii B, Setareh-Shenas R: Becker's nevus with ipsilateral breast hypoplasia: a case report and review of literature. Arch Iran Med; 2006 Jan;9(1):68-71
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  • [Title] Becker's nevus with ipsilateral breast hypoplasia: a case report and review of literature.
  • Specific cutaneous associations in patients with Becker's nevus have been reported.
  • We present a patient with typical clinical and histopathological features clearly consistent with Becker's nevus associated with ipsilateral breast hypoplasia.
  • The changes were distinct and could be separated from smooth muscle hamartoma.
  • [MeSH-major] Breast / pathology. Nevus, Pigmented / complications. Nevus, Pigmented / pathology. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 16649383.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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33. Roesch A, Becker B, Meyer S, Hafner C, Wild PJ, Landthaler M, Vogt T: Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma. Mod Pathol; 2005 Apr;18(4):565-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Disease Progression. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Melanocytes / chemistry. Melanocytes / metabolism. Melanocytes / pathology. Neoplasm Metastasis. Nevus, Pigmented / genetics. Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. Phosphorylation. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Serine / metabolism. Survival Analysis. Tissue Array Analysis / methods

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  • (PMID = 15502804.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Retinoblastoma Protein; 452VLY9402 / Serine
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34. Zarineh A, Kozovska ME, Brown WG, Elder DE, Rabkin MS: Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature. J Cutan Pathol; 2008 Oct;35 Suppl 1:83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature.
  • Smooth muscle hamartoma (SMH) is a rare benign congenital or acquired lesion sometimes associated with Becker's nevus (Becker's melanosis).
  • We report an unusual lesion with combined features of SMH and melanocytic nevus.
  • Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus.
  • [MeSH-major] Hamartoma / complications. Hamartoma / pathology. Muscle, Smooth / pathology. Nevus, Pigmented / complications. Nevus, Pigmented / congenital

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544054.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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35. Becker D, Mihm MC, Hewitt SM, Sondak VK, Fountain JW, Thurin M: Markers and tissue resources for melanoma: meeting report. Cancer Res; 2006 Nov 15;66(22):10652-7
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  • They also highlighted the ongoing challenges about translational research in melanoma, including availability of tissue resources, and summarized the status of nevus and melanoma tissue microarrays, recently developed as a collaborative project between the melanoma research community and the NCI.

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  • (PMID = 17108101.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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36. Smith AP, Hoek K, Becker D: Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas. Cancer Biol Ther; 2005 Sep;4(9):1018-29
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  • [Title] Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas.
  • To gain insights into the genetic profile of every stage of the melanoma progression pathway, and to determine to what extent these profiles are similar or distinct, we performed whole-genome expression profiling of tissue specimens representing normal skin, benign and atypical nevi, and early and advanced-stage melanomas.
  • [MeSH-minor] Carcinoma in Situ / genetics. Carcinoma in Situ / pathology. Cell Line, Tumor. Disease Progression. Humans. Neoplasm Staging. Nevus / chemistry. Nevus / genetics. Nevus / pathology. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16251803.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Gaiser T, Kutzner H, Palmedo G, Siegelin MD, Wiesner T, Bruckner T, Hartschuh W, Enk AH, Becker MR: Classifying ambiguous melanocytic lesions with FISH and correlation with clinical long-term follow up. Mod Pathol; 2010 Mar;23(3):413-9
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  • Recently, initial studies describing the use of multicolor fluorescence in situ hybridization (FISH) for classifying melanocytic skin lesions have been published demonstrating a high sensitivity and specificity in discriminating melanomas from nevi.
  • Comparison of array comparative genomic hybridization data with FISH analyses did not yield significant results but array comparative genomic hybridization data demonstrated that melanocytic skin lesions with the development of metastases showed significantly more chromosomal aberrations (P<0.01) compared with melanocytic skin lesions without the development of metastases.
  • [MeSH-major] In Situ Hybridization, Fluorescence. Melanocytes / pathology. Melanoma / classification. Nevus / classification. Skin Neoplasms / classification


38. Cordisco MR: An update on lasers in children. Curr Opin Pediatr; 2009 Aug;21(4):499-504
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  • Therefore, it is necessary to know the current trends and limitations of their use for the treatment of pigmented and vascular lesions.
  • Traditionally, the Q-switched pigmented laser has been used for pigmented lesions.
  • However, the 1550 nm wavelength erbium-doped fiber laser could be a new modality of treatment for Becker's nevus.
  • A large spectrum of vascular and pigmented lesions and other conditions such as chronic inflammatory skin diseases, such as psoriasis and eczema, keloids and hypertrichosis, are now managed safely with laser treatment.
  • [MeSH-major] Hemangioma / surgery. Laser Therapy / methods. Nevus / surgery. Port-Wine Stain / surgery. Skin Neoplasms / surgery

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  • (PMID = 19521240.001).
  • [ISSN] 1531-698X
  • [Journal-full-title] Current opinion in pediatrics
  • [ISO-abbreviation] Curr. Opin. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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39. Roesch A, Becker B, Bentink S, Spang R, Vogl A, Hagen I, Landthaler M, Vogt T: Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma. Cancer Epidemiol Biomarkers Prev; 2007 Nov;16(11):2486-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma.
  • The deep penetrating nevus (DPN) is a variant of benign melanocytic nevus with clinical and histologic features mimicking vertical growth phase, nodular malignant melanoma (NMM).
  • [MeSH-major] Biomarkers, Tumor / genetics. Cell Cycle Proteins / genetics. DNA-Binding Proteins / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Protein-Serine-Threonine Kinases / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 18006941.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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40. ul Bari A, Rahman SB: Acquired smooth muscle hamartoma. Indian J Dermatol Venereol Leprol; 2006 Mar-Apr;72(2):178

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  • [Title] Acquired smooth muscle hamartoma.
  • Smooth muscle hamartoma is an uncommon, usually congenital, cutaneous hyperplasia of the arrectores pilorum muscles.
  • When it is acquired, it may be confused with Becker's nevus.
  • The diagnosis of acquired smooth muscle hamartoma was confirmed on histopathology.
  • [MeSH-major] Hamartoma / pathology. Muscle, Smooth / pathology

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  • (PMID = 16707840.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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41. Roesch A, Becker B, Meyer S, Wild P, Hafner C, Landthaler M, Vogt T: Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. Mod Pathol; 2005 Sep;18(9):1249-57
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  • In the present study, we can confirm by real-time RT-PCR (six common melanocytic nevi, five advanced nodular melanomas and seven melanoma metastases) and immunohistochemistry (tissue microarrays: 52 melanocytic nevi, 60 melanomas, 60 metastases; and conventional sections: five common nevi, four advanced nodular melanomas, five melanoma metastases) that RBP2-H1 expression is progressively downregulated in advanced and metastatic melanomas in vivo with a certain intratumoral heterogeneity.
  • Whereas benign melanocytic nevi are RBP2-H1 positive in about 70% of the cases, a lack of RBP2-H1 expression was found in 90% of the primary malignant melanomas and 70% of the melanoma metastases, respectively.
  • [MeSH-minor] Base Sequence. Blotting, Western. Cell Line, Tumor. Down-Regulation. Humans. Immunohistochemistry. Immunoprecipitation. Molecular Sequence Data. Nevus / metabolism. Phylogeny. RNA, Messenger / analysis. Retinoblastoma Protein / metabolism. Retinoblastoma-Binding Protein 2. Reverse Transcriptase Polymerase Chain Reaction. Tissue Array Analysis

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  • (PMID = 15803180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Proteins; EC 1.14.11.- / KDM5A protein, human; EC 1.14.11.- / Retinoblastoma-Binding Protein 2
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42. Vetter CS, Müller-Blech K, Schrama D, Bröcker EB, Becker JC: Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions. Arch Dermatol Res; 2005 Jul;297(1):26-30
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  • In the present study, we compared the expression of survivin in melanoma and benign melanocytic lesions such as junctional, compound, dermal, congenital, blue and spitz nevi.
  • In junctional, compound and blue nevi, survivin was present in nuclear localization, whereas in spitz nevi survivin was detectable in the cytoplasm.
  • In dermal and congenital nevi, survivin was present in both localizations with predominance of the nuclear compartment.
  • Our data demonstrate that although survivin is expressed in a large number of benign nevi, the balance between its cytoplasmic and nuclear expression was immensely heterogeneous between lesions with suspected different developmental origins.
  • [MeSH-major] Cell Nucleus / chemistry. Cytoplasm / chemistry. Melanoma / chemistry. Microtubule-Associated Proteins / analysis. Neoplasm Proteins / analysis. Nevus / chemistry. Skin Neoplasms / chemistry

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  • (PMID = 15906050.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins
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43. Roesch A, Wittschier S, Becker B, Landthaler M, Vogt T: Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi. Mod Pathol; 2006 Oct;19(10):1378-85
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  • [Title] Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
  • The deep penetrating nevus is a rare variant of benign melanocytic nevus with histologic features mimicking vertical growth phase, nodular malignant melanoma.
  • Semiquantitative assessment of both immunolocalization and immunoreactivity of retinoblastoma protein and phospho-retinoblastoma protein Ser795, MIB-1/Ki-67, matrix metalloproteinase-1, matrix metalloproteinase-2, membrane-type matrix metalloproteinase-1 and integrin beta3 revealed no consistent differences between deep penetrating nevi (n=14) and matched cases of nodular malignant melanomas (n=10).
  • Matrix metalloproteinase-1 and matrix metalloproteinase-2 immunostaining of some deep penetrating nevi even exceeded that of nodular malignant melanomas.
  • Membrane-type matrix metalloproteinase-1 expression scores of nodular malignant melanomas were higher than those of deep penetrating nevi, which was, however, not significantly discriminative.
  • These results add evidence that among the selected markers supposed to be relevant for melanoma progression the presence of dipeptidyl peptidase IV can be used to support diagnosis of deep penetrating nevi in doubtful cases.
  • [MeSH-major] Adenosine Deaminase / analysis. Biomarkers, Tumor / analysis. Dipeptidyl Peptidase 4 / analysis. Glycoproteins / analysis. Melanoma / enzymology. Nevus, Pigmented / enzymology. Skin Neoplasms / enzymology

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  • (PMID = 16829852.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Ki-67 Antigen; 0 / MIB-1 antibody; 0 / Retinoblastoma Protein; EC 3.4.14.5 / DPP4 protein, human; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.5.4.4 / Adenosine Deaminase
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44. Schmidt CS, Bentz ML: Congenital smooth muscle hamartoma: the importance of differentiation from melanocytic nevi. J Craniofac Surg; 2005 Sep;16(5):926-9
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  • [Title] Congenital smooth muscle hamartoma: the importance of differentiation from melanocytic nevi.
  • Congenital smooth muscle hamartoma (CSMH) is a rare cutaneous lesion commonly seen on the trunk or extremities as a localized skin-colored or mildly hyperpigmented and irregularly shaped patch or plaque with prominent vellus hairs.
  • The clinical differential diagnosis of CSMH includes congenital melanocytic (pigmented) nevus, Becker's melanosis, solitary mastocytoma, piloleiomyoma, café-au-lait spots, and nevus pilosus.
  • Differentiating CSMH from a congenital melanocytic nevus avoids the unnecessary excision of this benign condition.
  • [MeSH-major] Hamartoma / congenital. Muscle, Smooth / pathology. Nevus, Pigmented / congenital. Skin Diseases / congenital. Skin Neoplasms / congenital
  • [MeSH-minor] Cafe-au-Lait Spots / diagnosis. Diagnosis, Differential. Humans. Infant. Leiomyoma / diagnosis. Male. Mastocytoma / diagnosis. Melanosis / diagnosis. Nevus / diagnosis

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  • (PMID = 16192884.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Haferkamp S, Scurr LL, Becker TM, Frausto M, Kefford RF, Rizos H: Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors. J Invest Dermatol; 2009 Aug;129(8):1983-91
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  • Human nevus cells frequently express oncogenic N-RAS or B-RAF, and are thought to be permanently growth arrested.
  • Many studies have suggested that the p16(INK4a) and, to a lesser extent, the p14ARF tumor suppressor proteins act as critical triggers of oncogene-induced senescence in nevi, and thus these proteins represent major inhibitors of progression to melanoma.
  • Our data are consistent with observations showing that senescent nevus cells do not always express p16(INK4a), and highlight the need to thoroughly explore INK4a/ARF-independent molecular pathways of senescence in human melanocytes.

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  • (PMID = 19212341.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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46. Bukvić Mokos Z, Lipozenčić J, Ceović R, Stulhofer Buzina D, Kostović K: Laser therapy of pigmented lesions: pro and contra. Acta Dermatovenerol Croat; 2010;18(3):185-9
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  • [Title] Laser therapy of pigmented lesions: pro and contra.
  • Although frequently performed, laser removal of pigmented lesions still contains certain controversial issues.
  • Epidermal pigmented lesions include solar lentigines, ephelides, café au lait macules and seborrheic keratoses.
  • Dermal lesions include melanocytic nevi, blue nevi, drug induced hyperpigmentation and nevus of Ota and Ito.
  • Some lesions exhibit both an epidermal and dermal component like Becker's nevus, postinflammatory hyperpigmentations, melasma and nevus spilus.
  • Due to the wide absorption spectrum of melanin (500-1100 nm), several laser systems are effective in removal of pigmented lesions.
  • These lasers include the pigmented lesion pulsed dye laser (510 nm), the Q-switched ruby laser (694 nm), the Q-switched alexandrite laser (755 nm) and the Q-switched Nd:YAG laser (1064 nm), which can be frequency-doubled to produce visible green light with a wavelength of 532 nm.
  • However, there are still many controversies regarding the use of lasers in treating certain pigmented lesions.
  • Actually, the essential question in removing pigmented lesions with lasers is whether the lesion has atypical features or has a malignant potential.
  • [MeSH-major] Hyperpigmentation / therapy. Laser Therapy

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  • (PMID = 20887701.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
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47. Choi JC, Yang JH, Lee UH, Park HS, Chun DK: Progressive cribriform and zosteriform hyperpigmentation--the late onset linear and whorled nevoid hypermelanosis. J Eur Acad Dermatol Venereol; 2005 Sep;19(5):638-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progressive cribriform and zosteriform hyperpigmentation--the late onset linear and whorled nevoid hypermelanosis.
  • [MeSH-major] Hyperpigmentation / pathology. Skin Abnormalities / pathology
  • [MeSH-minor] Adolescent. Biopsy, Needle. Disease Progression. Follow-Up Studies. Humans. Immunohistochemistry. Male. Melanosis / pathology

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  • (PMID = 16164727.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
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48. Patrizi A, Medri M, Neri I, Fanti PA: Becker naevus associated with basal cell carcinoma, melanocytic naevus and smooth-muscle hamartoma. J Eur Acad Dermatol Venereol; 2007 Jan;21(1):130-2
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  • [Title] Becker naevus associated with basal cell carcinoma, melanocytic naevus and smooth-muscle hamartoma.
  • [MeSH-major] Carcinoma, Basal Cell / complications. Hamartoma / complications. Muscle, Smooth / pathology. Muscular Diseases / complications. Nevus / complications

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  • (PMID = 17207195.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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49. Do JE, Kim YJ, Kang HY: Hypohidrosis colocalized with Becker's naevus. Br J Dermatol; 2007 Apr;156(4):766-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypohidrosis colocalized with Becker's naevus.
  • [MeSH-major] Hypertrichosis / genetics. Hypohidrosis / complications. Nevus, Pigmented / complications

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  • (PMID = 17263814.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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50. Vetter-Kauczok CS, Becker JC, Bröcker EB: Sclerosing 'mucinous' blue nevus: a clinical simulator of dermatofibroma. Clin Med Pathol; 2008;1:15-6

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  • [Title] Sclerosing 'mucinous' blue nevus: a clinical simulator of dermatofibroma.

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  • [Cites] Br J Dermatol. 2003 May;148(5):1064-6 [12786849.001]
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  • (PMID = 21876647.001).
  • [ISSN] 1178-1181
  • [Journal-full-title] Clinical medicine. Pathology
  • [ISO-abbreviation] Clin Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3160009
  • [Keywords] NOTNLM ; mucin / nevus / sclerotic
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51. Bansal R, Sen R: Bilateral Becker's nevi. Indian J Dermatol Venereol Leprol; 2008 Jan-Feb;74(1):73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral Becker's nevi.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 18187838.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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52. Köse O, Calişkan E, Kurumlu Z: Three different epidermal naevi with no organ involvement: sebaceous naevus, naevus comedonicus and Becker's naevus. Acta Derm Venereol; 2008;88(1):67-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three different epidermal naevi with no organ involvement: sebaceous naevus, naevus comedonicus and Becker's naevus.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nevus / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology

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  • (PMID = 18176758.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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53. Kim SY, Kim MY, Kang H, Kim HO, Park YM: Becker's naevus in a patient with neurofibromatosis. J Eur Acad Dermatol Venereol; 2008 Mar;22(3):394-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Becker's naevus in a patient with neurofibromatosis.
  • [MeSH-major] Hamartoma / etiology. Neurofibromatoses / complications. Nevus, Pigmented / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Adult. Humans. Hyperpigmentation / etiology. Hyperpigmentation / pathology. Male. Skin / pathology

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  • (PMID = 18269623.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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54. Use of Lasers for Becker's Nevus and Keratosis Pilaris. J Cutan Aesthet Surg; 2008 Jul;1(2):112

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of Lasers for Becker's Nevus and Keratosis Pilaris.

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  • (PMID = 20300360.001).
  • [ISSN] 0974-5157
  • [Journal-full-title] Journal of cutaneous and aesthetic surgery
  • [ISO-abbreviation] J Cutan Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2840912
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55. Sirka CS, Puhan MR, Behera S, Mohanty P, Nanda M: Becker's nevus with ipsilateral breast hypoplasia. Indian J Dermatol Venereol Leprol; 2009 Mar-Apr;75(2):202-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Becker's nevus with ipsilateral breast hypoplasia.
  • [MeSH-major] Breast / abnormalities. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19293523.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Receptors, Androgen
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56. Lockshin BN, Brogan B, Billings S: Eczematous dermatitis and prurigo nodularis confined to a Becker's nevus. Int J Dermatol; 2006 Dec;45(12):1465-6
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eczematous dermatitis and prurigo nodularis confined to a Becker's nevus.
  • [MeSH-major] Eczema / pathology. Hamartoma / pathology. Prurigo / pathology. Skin Diseases / pathology

  • Genetic Alliance. consumer health - Nevus.
  • Genetic Alliance. consumer health - Prurigo nodularis.
  • Genetic Alliance. consumer health - Becker's Nevus.
  • MedlinePlus Health Information. consumer health - Eczema.
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  • [ErratumIn] Int J Dermatol. 2007 Mar;46(3):339. Billings, Stephen [corrected to Billings, Steven]
  • (PMID = 17184268.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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57. Glaich AS, Goldberg LH, Dai T, Kunishige JH, Friedman PM: Fractional resurfacing: a new therapeutic modality for Becker's nevus. Arch Dermatol; 2007 Dec;143(12):1488-90
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fractional resurfacing: a new therapeutic modality for Becker's nevus.
  • [MeSH-major] Hypertrichosis / etiology. Laser Therapy. Nevus, Pigmented / complications. Nevus, Pigmented / surgery. Skin Neoplasms / complications. Skin Neoplasms / surgery

  • Genetic Alliance. consumer health - Nevus.
  • Genetic Alliance. consumer health - Becker's Nevus.
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  • (PMID = 18086996.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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