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6. Lash TL, Pedersen L, Cronin-Fenton D, Ahern TP, Rosenberg CL, Lunetta KL, Silliman RA, Hamilton-Dutoit S, Garne JP, Ewertz M, Sørensen HT: Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram. Br J Cancer; 2008 Aug 19;99(4):616-21
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  • [Title] Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram.
  • Tamoxifen remains an important adjuvant therapy to reduce the rate of breast cancer recurrence among patients with oestrogen-receptor-positive tumours.
  • This enzyme also metabolizes selective serotonin reuptake inhibitors (SSRI), so these widely used drugs - when taken concurrently - may reduce tamoxifen's prevention of breast cancer recurrence.
  • We studied citalopram use in 184 cases of breast cancer recurrence and 184 matched controls without recurrence after equivalent follow-up.
  • Cases and controls were nested in a population of female residents of Northern Denmark with stages I-III oestrogen-receptor-positive breast cancer 1985-2001 and who took tamoxifen for 1, 2, or most often for 5 years.
  • Seventeen cases (9%) and 21 controls (11%) received at least one prescription for the SSRI citalopram while taking tamoxifen (adjusted conditional odds ratio=0.85, 95% confidence interval=0.42, 1.7).
  • These results suggest that concurrent use of citalopram does not reduce tamoxifen's prevention of breast cancer recurrence.

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  • (PMID = 18665165.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA118708-03; United States / NCI NIH HHS / CA / R01 CA118708; United States / NCI NIH HHS / CA / R01 CA118708-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Serotonin Uptake Inhibitors; 094ZI81Y45 / Tamoxifen; 0DHU5B8D6V / Citalopram
  • [Other-IDs] NLM/ NIHMS66426; NLM/ PMC2527838
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7. Unlü A, Ates NA, Tamer L, Ates C: Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk. Cell Biochem Funct; 2008 Sep-Oct;26(5):643-7
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  • [Title] Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk.
  • The aim of this study was to investigate associations between genetic variability in specific Glutathione S-transferases (GST) genes (GSTM1, GSTT1 and GSTP1) and susceptibility to breast cancer.
  • Genotypes of blood specimen DNA were determined for 65 women with incident cases of breast cancer and 108 control subjects.
  • Associations between specific genotypes and the development of breast cancer were examined by the use of logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
  • Neither GSTT1 nor GSTM1 homozygous null genotype was associated with a significant increased risk of developing breast cancer.
  • The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development.
  • The risk of breast cancer associated with a combined GSTT1 and GSTM1 null genotype was 3.37 (95% CI = 0.76-2.95, p = 0.115).
  • The only significant association between increased risk of breast cancer development and GSTs polymorphisms was found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 were combined (p < 0.048, OR = 3.75, 95% CI = 1.01-13.90).
  • Our findings suggest that combined genetic variability in members of the GST gene family may be associated with an increased susceptibility to breast cancer.
  • [MeSH-major] Breast Neoplasms / enzymology. Breast Neoplasms / genetics. Genetic Predisposition to Disease. Glutathione S-Transferase pi / genetics. Glutathione Transferase / genetics
  • [MeSH-minor] Alleles. Amino Acid Substitution / genetics. Case-Control Studies. Female. Genotype. Humans. Isoenzymes / deficiency. Isoenzymes / genetics. Isoleucine / genetics. Middle Aged. Multigene Family. Risk Factors. Turkey / epidemiology. Valine / genetics

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  • (PMID = 18521819.001).
  • [ISSN] 1099-0844
  • [Journal-full-title] Cell biochemistry and function
  • [ISO-abbreviation] Cell Biochem. Funct.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; 04Y7590D77 / Isoleucine; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1; HG18B9YRS7 / Valine
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8. Uppal H, Zhai Y, Gangopadhyay A, Khadem S, Ren S, Moser JA, Xie W: Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization. Hepatology; 2008 Apr;47(4):1331-42
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  • [Title] Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization.
  • Gallstone disease is a hepatobiliary disorder due to biochemical imbalances in the gallbladder bile.
  • In this report, we show that activation of nuclear receptor liver X receptor (LXR) sensitized mice to lithogenic diet-induced gallbladder cholesterol crystallization, which was associated with dysregulation of several hepatic transporters that efflux cholesterol, phospholipids, and bile salts.
  • The combined effect of increased biliary concentrations of cholesterol and phospholipids and decreased biliary concentrations of bile salts in LXR-activated mice led to an increased cholesterol saturation index and the formation of cholesterol crystals.
  • Interestingly, the lithogenic effect of LXR was completely abolished in the low-density lipoprotein receptor (Ldlr) null background or when the mice were treated with Ezetimibe, a cholesterol-lowering drug that blocks intestinal dietary cholesterol absorption.
  • These results suggest that LDLR-mediated hepatic cholesterol uptake and intestinal cholesterol absorption play an essential role in LXR-promoted lithogenesis.
  • CONCLUSION: The current study has revealed a novel lithogenic role of LXR as well as a functional interplay between LXR and LDLR in gallbladder cholesterol crystallization and possibly cholesterol gallstone disease (CGD).
  • We propose that LXR is a lithogenic factor and that the LXR transgenic mice may offer a convenient CGD model to develop therapeutic interventions for this disease.
  • [MeSH-major] Cholesterol / metabolism. DNA-Binding Proteins / metabolism. Gallbladder / metabolism. Gallstones / metabolism. Receptors, Cytoplasmic and Nuclear / metabolism

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  • (PMID = 18318438.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA107011; United States / NIEHS NIH HHS / ES / ES014626
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Azetidines; 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / Orphan Nuclear Receptors; 0 / Phospholipids; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, LDL; 0 / liver X receptor; 97C5T2UQ7J / Cholesterol; EOR26LQQ24 / Ezetimibe
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9. Villalon-Lopez JS, Valle-Mejia CA, Patino-Lara A, Moreno-Perez BA, Munoz-Lopez JA, Alcantar-Andrade A: Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review. J Cancer Res Ther; 2006 Jul-Sep;2(3):140-3
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  • [Title] Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review.
  • Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans, with cumulative exposure to ultraviolet radiation as an important risk factor for development of illness such as severe solar burns during childhood or adolescence.
  • BCC is mainly located on sun-exposed sites, head and neck being the areas of more incidences; although nose, eyelids and periorbitary tissue are unfavorable due to cosmetic results that BCC involves.
  • The goal of treatment is complete excision of the tumor with preservation of surrounding structures in a way aesthetically acceptable.
  • Mohs' micrographic surgery is the standard treatment for all nonmelanoma skin cancers.
  • Orbital exenteration is also used for treatment of malignancies of ocular tissues, mainly squamous cell carcinoma, sebaceous cell carcinoma and BCC.
  • The case of a 77-year-old patient is presented with BCC of inferior eyelid of 14 years' duration, formerly managed with radiotherapy; however, due to recurrent illness and invasion to the maxillary antrum, he needed supraestructure maxillectomy with left orbital exenteration.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Maxilla / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17998694.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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10. Kara E, Shade A: Temporal dynamics of South End tidal creek (Sapelo Island, Georgia) bacterial communities. Appl Environ Microbiol; 2009 Feb;75(4):1058-64
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  • Dissolved oxygen concentration and conductivity were important proximate drivers.

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  • (PMID = 19114517.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 059QF0KO0R / Water; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ PMC2643588
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11. Mebed AH, Soliman HO, Gad ZS, Abdel Hay RM: Multimodality treatment for non melanoma skin cancer: a prospective study done on 120 egyptian patients. J Egypt Natl Canc Inst; 2010 Mar;22(1):49-55
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  • [Title] Multimodality treatment for non melanoma skin cancer: a prospective study done on 120 egyptian patients.
  • BACKGROUND: Multiple currently accepted treatments for non melanoma skin cancer (NMSC) are now available.
  • KEY WORDS: BCC - Interferon - Retinoids - SCC.

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  • (PMID = 21503006.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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12. Oganov AR, Ma Y, Xu Y, Errea I, Bergara A, Lyakhov AO: Exotic behavior and crystal structures of calcium under pressure. Proc Natl Acad Sci U S A; 2010 Apr 27;107(17):7646-51
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  • Experimental studies established that calcium undergoes several counterintuitive transitions under pressure: fcc --> bcc --> simple cubic --> Ca-IV --> Ca-V, and becomes a good superconductor in the simple cubic and higher-pressure phases.
  • The beta-tin (I4(1)/amd) structure, rather than simple cubic, is predicted to be the theoretical ground state at 0 K and 33-71 GPa.
  • This structure can be represented as a large distortion of the simple cubic structure, just as the higher-pressure phases stable between 71 and 134 GPa.
  • The structure of Ca-V, stable above 134 GPa, is a complex host-guest structure.

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  • (PMID = 20382865.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2867850
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13. Kim DY, Cho SB, Chung KY, Kim YC: Clear cell basal cell carcinoma with sialomucin deposition. Yonsei Med J; 2006 Dec 31;47(6):870-2
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  • [Title] Clear cell basal cell carcinoma with sialomucin deposition.
  • Clear cell basal cell carcinoma (BCC) is a variant of BCC with a characteristic clear cell component that may occupy all or part of the tumor islands.
  • However, to our knowledge, clear cell BCC with sialomucin deposition has not been reported.
  • Here we report a case of clear cell BCC showing sialomucin deposition.
  • The clear tumor cells stained with PAS and showed incomplete diastase-resistance.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Sialomucins / analysis

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  • (PMID = 17191318.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Sialomucins
  • [Other-IDs] NLM/ PMC2687829
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4. Depianto D, Kerns ML, Dlugosz AA, Coulombe PA: Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet; 2010 Oct;42(10):910-4
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  • [Title] Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.
  • Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the case of BCC, an expanding set of genetic variants including keratin 5 (encoded by KRT5), an intermediate filament-forming protein.
  • We here show that genetic ablation of keratin 17 (Krt17) protein, which is induced in basaloid skin tumors and co-polymerizes with Krt5 in vivo, delays basaloid follicular hamartoma tumor initiation and growth in mice with constitutive Hh signaling in epidermis.
  • Re-expression of Krt17 in Gli2(tg); Krt17(-/-) keratinocytes induces select Th1 chemokines that have established roles in BCC.
  • Our findings establish an immunomodulatory role for Krt17 in Hh driven basaloid skin tumors that could impact additional tumor settings, psoriasis and wound repair.

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  • (PMID = 20871598.001).
  • [ISSN] 1546-1718
  • [Journal-full-title] Nature genetics
  • [ISO-abbreviation] Nat. Genet.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA160255; United States / NIAMS NIH HHS / AR / R01 AR044232-14; United States / NCI NIH HHS / CA / CA123530-02; United States / NCI NIH HHS / CA / R21 CA123530; United States / NCI NIH HHS / CA / T32 CA009110; United States / NCI NIH HHS / CA / CA123530; United States / NIAMS NIH HHS / AR / AR44232; United States / NCI NIH HHS / CA / R21 CA123530-02; United States / NCI NIH HHS / CA / F32 CA110618; United States / NIAMS NIH HHS / AR / R01 AR044232; United States / NCI NIH HHS / CA / R01 CA087837; United States / NCI NIH HHS / CA / CA087837; United States / NIAMS NIH HHS / AR / AR044232-14
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gli2 protein; 0 / Hedgehog Proteins; 0 / KRT1-17 protein, mouse; 0 / Kruppel-Like Transcription Factors; 0 / RNA, Messenger; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ NIHMS231459; NLM/ PMC2947596
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15. Hu WP, Chen YK, Liao CC, Yu HS, Tsai YM, Huang SM, Tsai FY, Shen HC, Chang LS, Wang JJ: Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. Bioorg Med Chem; 2010 Aug 15;18(16):6197-207
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  • Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC).
  • 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315-400 nm).
  • Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated 6 in BCC cells are carried out in the present article.
  • These results suggest that 6-UVA elicits photosensitive effects in mitochondria processes which involve ERK and p38 activation, and ultimately lead to BCC cell apoptosis.
  • [MeSH-major] Benzothiazoles / chemistry. Benzothiazoles / pharmacology. Carcinoma, Basal Cell / drug therapy. Photosensitizing Agents / chemistry. Photosensitizing Agents / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Apoptosis / radiation effects. Cell Line, Tumor. Cell Survival / drug effects. Cell Survival / radiation effects. Humans. MAP Kinase Signaling System / drug effects. Mitochondria / drug effects. Mitochondria / pathology. Mitochondria / radiation effects. Photochemotherapy. Ultraviolet Rays

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20637639.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-(4-aminophenyl)benzothiazole; 0 / Benzothiazoles; 0 / Photosensitizing Agents
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16. Kutty PK, Moody B, Gullion JS, Zervos M, Ajluni M, Washburn R, Sanderson R, Kainer MA, Powell TA, Clarke CF, Powell RJ, Pascoe N, Shams A, LiPuma JJ, Jensen B, Noble-Wang J, Arduino MJ, McDonald LC: Multistate outbreak of Burkholderia cenocepacia colonization and infection associated with the use of intrinsically contaminated alcohol-free mouthwash. Chest; 2007 Dec;132(6):1825-31
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  • METHODS: We conducted a case-series investigation.
  • We used repetitive extragenic palindromic- polymerase chain reaction typing and pulsed-field gel electrophoresis (PFGE) to characterize available Burkholderia cepacia complex (Bcc) isolates from patients and implicated AFM.
  • RESULTS: Of the 116 patients with Bcc infection or colonization identified from 22 hospitals with culture dates from April 7 through August 31, 2005, 105 had infections or colonizations that were due to B cenocepacia.
  • Among 103 Bcc patient isolates characterized, 81 (76%) had an indistinguishable PFGE pattern compared to the outbreak strain cultured from implicated lots of unopened AFM; the species was B cenocepacia.
  • CONCLUSIONS: This intrinsically contaminated AFM led to a geographically dispersed outbreak of B cenocepacia.
  • [MeSH-major] Burkholderia Infections / etiology. Burkholderia cepacia / pathogenicity. Disease Outbreaks. Drug Contamination. Mouthwashes
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Case-Control Studies. Child. Electrophoresis, Gel, Pulsed-Field. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. United States / epidemiology

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  • (PMID = 17925414.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mouthwashes
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17. Ibiebele TI, van der Pols JC, Hughes MC, Marks GC, Williams GM, Green AC: Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study. Am J Clin Nutr; 2007 May;85(5):1401-8
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  • [Title] Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study.
  • BACKGROUND: The role of diet in the development of skin cancer is inconclusive, and the effect of the combined consumption of foods has never been reported.
  • OBJECTIVE: We prospectively investigated the association between dietary patterns and cutaneous basal cell (BCC) and squamous cell (SCC) carcinoma.
  • DESIGN: Principal components analysis of 38 food groups was used to identify dietary patterns in 1360 adults aged 25-75 y who participated in a community-based skin cancer study in Nambour, Australia, between 1992 and 2002.
  • We obtained baseline information about diet, skin color, and sun exposure factors.
  • Multivariate-adjusted relative risks (RRs) for BCC and SCC tumors were estimated by using negative binomial regression modeling.
  • The meat and fat pattern was positively associated with development of SCC tumors (RR=1.83; 95% CI: 1.00, 3.37; P for trend=0.05) after adjustment for confounders and even more strongly associated in participants with a skin cancer history (RR=3.77; 95% CI: 1.65, 8.63; P for trend = 0.002) when the third and first tertiles were compared.
  • A higher consumption of the vegetable and fruit dietary pattern appeared to decrease SCC tumor risk by 54% (P for trend = 0.02), but this protective effect was mostly explained by the association with green leafy vegetables.
  • There was no association between the dietary patterns and BCC tumors.
  • CONCLUSION: A dietary pattern characterized by high meat and fat intakes increases SCC tumor risk, particularly in persons with a skin cancer history.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Diet. Skin Neoplasms / epidemiology

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  • (PMID = 17490979.001).
  • [ISSN] 0002-9165
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats
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18. Hannay HJ, Walker A, Dennis M, Kramer L, Blaser S, Fletcher JM: Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele. J Int Neuropsychol Soc; 2008 Sep;14(5):771-81
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  • [Title] Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele.
  • Spina bifida meningomyelocele with hydrocephalus (SBM) is commonly associated with anomalies of the corpus callosum (CC).
  • Many children with SBM (n = 40) showed regional CC anomalies in the form of agenesis of the rostrum and/or splenium, and a smaller number (n = 20) showed hypoplasia (thinning) of all CC regions (rostrum, genu, body, and splenium).

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  • (PMID = 18764972.001).
  • [ISSN] 1469-7661
  • [Journal-full-title] Journal of the International Neuropsychological Society : JINS
  • [ISO-abbreviation] J Int Neuropsychol Soc
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD035946-10; United States / NICHD NIH HHS / HD / P01 HD035946; United States / NICHD NIH HHS / HD / P01 HD035946-10; United States / NICHD NIH HHS / HD / P01 HD35946
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS113790; NLM/ PMC2754745
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19. Li LJ, Li Y, Wen YM, Liu H, Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol; 2008 Feb;44(2):187-92
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  • [Title] Clinical analysis of salivary gland tumor cases in West China in past 50 years.
  • In our study, 3461 cases of salivary gland tumor treated between 1955 and 2002 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed, and compared with the previous reports.
  • Measures such as age, tumor location, tumor histological type, and the nature of the growth (benign or malignant) were recorded at the same time.
  • The findings are as follows: the average ages of salivary gland tumor patients were 41.38 years for the benign cases and 45.20 for the malignant ones; the male:female ratio was 0.
  • 99:1 in the benign cases and 1.34:1 in the malignant ones; primary tumors were mostly in the parotid gland, palate and submandibular gland in sequence.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor and basal cell adenoma, whereas mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma not otherwise specified were the most frequent malignant tumors.
  • The male:female ratio of malignant tumors was higher than that of benign ones.
  • Pleomorphic adenoma and mucoepidermoid carcinoma were the most frequent benign and malignant tumors, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology. Retrospective Studies

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  • [ErratumIn] Oral Oncol. 2011 Sep;47(9):929-30
  • (PMID = 17418612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. Utikal J, Udart M, Leiter U, Kaskel P, Peter RU, Krähn G: Numerical abnormalities of the Cyclin D1 gene locus on chromosome 11q13 in non-melanoma skin cancer. Cancer Lett; 2005 Mar 10;219(2):197-204
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  • [Title] Numerical abnormalities of the Cyclin D1 gene locus on chromosome 11q13 in non-melanoma skin cancer.
  • Deregulation of the cell-cycle G1-restriction point control via abnormalities of Rb-pathway components is a frequent event in the formation of cancer.
  • The aim of this study was to evaluate numerical aberrations of the Cyclin D1 (CCND1, PRAD1, bcl-1) gene locus at chromosome 11q13 in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin and to compare it with the Cyclin D1 protein expression.
  • Six of the 30 (20%) SCCs showed additional Cyclin D1 gene copies and 2/30 (6.6%) cases had a loss of the Cyclin D1 gene locus in relation to the centromere 11 number.
  • In contrast, only one of the 14 BCCs (7%) showed one additional Cyclin D1 gene copy in relation to the centromere 11 number.
  • None of the BCCs demonstrated aneusomy for chromosome 11 in contrast to SCCs, where it was found in 21/30 (70%) cases.
  • Twenty-six of the 30 (86.6%) cutaneous SCCs and 13/14 (93%) BCCs expressed Cyclin D1 protein.
  • All SCCs and the BCC with additional Cyclin D1 gene copies showed positivity for Cyclin D1 protein.
  • Our findings suggest that numerical abnormalities of the Cyclin D1 gene locus could result in an altered gene-dose effect, possibly leading to an aberrant expression in affected tumor cells.
  • This might result in deregulation of cell cycle control, eventually leading to uncontrolled cell cycle progression.
  • [MeSH-major] Aneuploidy. Carcinoma, Basal Cell / genetics. Carcinoma, Squamous Cell / genetics. Chromosomes, Human, Pair 11. Cyclin D1 / genetics. Cyclin D1 / metabolism. Skin Neoplasms / genetics


21. Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH, Linet MS, Ron E, Mabuchi K: Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists. Int J Cancer; 2005 Jul 10;115(5):828-34
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  • [Title] Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists.
  • Ionizing radiation (IR) is an established cause of nonmelanoma skin cancer, but there is uncertainty about the risk associated with chronic occupational exposure to IR and how it is influenced by ultraviolet radiation (UVR) exposure.
  • We studied 1,355 incident cases with basal cell carcinoma (BCC) and 270 with squamous cell carcinoma (SCC) of the skin in a cohort of 65,304 U.S. white radiologic technologists who responded to the baseline questionnaire survey in 1983-1989 and the follow-up survey in 1994-1998.
  • Cox's proportional-hazards model was used to estimate relative risks of BCC and SCC associated with surrogate measures of occupational exposure to IR and residential UVR exposure during childhood and adulthood, adjusted for potential confounders including pigmentation characteristics.
  • Relative risks of BCC, but not of SCC, were elevated among technologists who first worked during the 1950s (RR = 1.42; 95% CI = 1.12-1.80), 1940s (RR = 2.04; 95% CI = 1.44-2.88) and before 1940 (RR = 2.16; 95% CI = 1.14-4.09), when IR exposures were high, compared to those who first worked after 1960 (p for trend < 0.01).
  • The effect of year first worked on BCC risk was not modified by UVR exposure, but was significantly stronger among individuals with lighter compared to darker eye and hair color (p = 0.013 and 0.027, respectively).
  • This study provides some evidence that chronic occupational exposure to IR at low to moderate levels can increase the risk of BCC, and that this risk may be modified by pigmentation characteristics.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Carcinoma, Squamous Cell / etiology. Occupational Exposure. Radiation Injuries / etiology. Radiology / manpower. Skin Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Allied Health Personnel. Cohort Studies. Female. Humans. Male. Middle Aged. Radiation, Ionizing. Risk Factors. Skin Pigmentation

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15704092.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CP / N01-CP-15673; United States / NCI NIH HHS / CP / N01-CP-51016; United States / NCI NIH HHS / CP / N02-CP-81005; United States / NCI NIH HHS / CP / N02-CP-81121
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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22. Scalvenzi M, Francia MG, Falleti J, Balato A: Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature. Pediatr Dermatol; 2008 May-Jun;25(3):359-63
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  • [Title] Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature.
  • We report the case of a 13-year-old girl with a 7 mm plaque on the trunk.
  • In 2003 a dermoscopic examination was executed and a diagnosis of dermical nevus was made.
  • On examination at our department, a red-pinkish plaque with two small areas of ulceration was found on the anterior part of the trunk.
  • A diagnosis of basal cell carcinoma was made and confirmed by histopathologic examination.
  • Basal cell carcinoma occurs rarely in children and is most often associated with an underlying condition that predisposes patients to the development of malignancy that was not present in our case.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Dermoscopy. Diagnosis, Differential. Female. Humans

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  • (PMID = 18577044.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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23. Ballmaier M, Kumar A, Elderkin-Thompson V, Narr KL, Luders E, Thompson PM, Hojatkashani C, Pham D, Heinz A, Toga AW: Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity. Neuropsychopharmacology; 2008 Jun;33(7):1528-36
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  • [Title] Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity.
  • There is some evidence of corpus callosum abnormalities in elderly depression, but it is not known whether these deficits are region-specific or differ based on age at onset of depression.
  • Using 3D MRI data, novel mesh-based geometrical modeling methods were applied to compare the midsagittal thickness of the corpus callosum at high spatial resolution between groups.
  • The splenium of the corpus callosum was also significantly thinner in subjects with late- vs early-onset depression.
  • Circumscribed structural alterations in callosal morphology may distinguish late- from early-onset depression in the elderly.

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  • (PMID = 17712348.001).
  • [ISSN] 0893-133X
  • [Journal-full-title] Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • [ISO-abbreviation] Neuropsychopharmacology
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / R01 MH055115-06; United States / NCRR NIH HHS / RR / RR013642-11; None / None / / R01 MH061567-05; United States / NIMH NIH HHS / MH / K01 MH073990; United States / NIMH NIH HHS / MH / MH055115-06; United States / NIMH NIH HHS / MH / K02 MH002043; United States / NIMH NIH HHS / MH / MH063764-04; United States / NCRR NIH HHS / RR / M01 RR000865-36; United States / NIMH NIH HHS / MH / R01 MH063764; United States / NIMH NIH HHS / MH / MH-61567; United States / NIMH NIH HHS / MH / MH-55115; United States / NCRR NIH HHS / RR / U54 RR021813-05; United States / NCRR NIH HHS / RR / U54 RR021813-01; United States / NCRR NIH HHS / RR / P41 RR013642-11; United States / NIMH NIH HHS / MH / R01 MH055115; United States / NIMH NIH HHS / MH / K01 MH073990-03; United States / NCRR NIH HHS / RR / P41 RR013642; United States / NIMH NIH HHS / MH / MH-02043; United States / NCRR NIH HHS / RR / U54 RR021813; United States / NCRR NIH HHS / RR / RR021813-01; United States / NIMH NIH HHS / MH / R01 MH061567; United States / NIMH NIH HHS / MH / MH073990-03; None / None / / K02 MH002043-05; United States / NIMH NIH HHS / MH / R01 MH063764-04; United States / NIMH NIH HHS / MH / R01 MH061567-05; United States / NIMH NIH HHS / MH / K02 MH002043-05; United States / NIMH NIH HHS / MH / R01-MH-63674
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS107496; NLM/ PMC2810852
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24. Balci S, Güçer S, Orhan D, Karagöz T: A well-documented trisomy 13 case presenting with a number of common and uncommon features of the syndrome. Turk J Pediatr; 2008 Nov-Dec;50(6):595-9
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  • [Title] A well-documented trisomy 13 case presenting with a number of common and uncommon features of the syndrome.
  • In this paper, we present a new trisomy 13 case associated with unusual and undescribed findings.
  • Unfortunately, the parents did not accept the prenatal diagnosis.
  • He died of congenital heart disease and sepsis on the 12th hospital day.
  • A complete autopsy revealed a scalp and a skull defect at the vertex, aplasia of the 5th finger nails, a complex heart disease including pulmonary trunk atresia, patent foramen ovale, membranous ventricular septal defect (VSD), main aorticopulmonary collateral artery (MAPCA) and aortic dextroposition, arrhinencephaly, partial agenesis of the corpus callosum, and neuronal heterotopias in the cerebellum.
  • To our knowledge, this is a unique trisomy 13 case with numerous common and uncommon features including a bone defect in the skull, partial agenesis of the corpus callosum, aplasia of the 5th finger nails, and a complex heart disease including pulmonary atresia, patent foramen ovale, membranous VSD, MAPCA and aortic dextroposition, which have not been published previously in the relevant literature all together.

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  • (PMID = 19227428.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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25. Li J, Humphreys K, Eriksson L, Czene K, Liu J, Hall P: Effects of childhood body size on breast cancer tumour characteristics. Breast Cancer Res; 2010;12(2):R23
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  • [Title] Effects of childhood body size on breast cancer tumour characteristics.
  • INTRODUCTION: Although a role of childhood body size in postmenopausal breast cancer risk has been established, less is known about its influence on tumour characteristics.
  • METHODS: We studied the relationships between childhood body size and tumour characteristics in a Swedish population-based case-control study consisting of 2,818 breast cancer cases and 3,111 controls.
  • Our classification of childhood body size was derived from a nine-level somatotype.
  • Association between somatotype at age 7 and tumour characteristics were evaluated in a case-only analysis where P values for heterogeneity were obtained by performing one degree of freedom trend tests.
  • RESULTS: A large somatotype at age 7 was found to be associated with decreased postmenopausal breast cancer risk.
  • Although strongly associated with other risk factors such as age of menarche, adult body mass index and mammographic density, somatotype at age 7 remained a significant protective factor (odds ratio (OR) comparing large to lean somatotype at age 7 = 0.73, 95% confidence interval (CI) = 0.58-0.91, P trend = 0.004) after adjustment.
  • Somatotype at age 7 was not associated with tumour size, histology, grade or the presence or absence of metastatic nodes.
  • CONCLUSIONS: Greater body size at age 7 is associated with a decreased risk of postmenopausal breast cancer, and the associated protective effect is stronger for the ER-negative breast cancer subtype than for the ER-positive subtype.

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  • (PMID = 20398298.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA58427
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2879571
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31. Bunyapaiboonsri T, Yoiprommarat S, Khonsanit A, Komwijit S: Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080. J Nat Prod; 2008 May;71(5):891-4
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  • [Title] Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080.
  • New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080.
  • [MeSH-minor] Animals. Cercopithecus aethiops. Drug Screening Assays, Antitumor. Humans. Hydroxybenzoates / chemistry. Hydroxybenzoates / isolation & purification. Hydroxybenzoates / pharmacology. Inhibitory Concentration 50. Molecular Structure

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  • (PMID = 18363379.001).
  • [ISSN] 0163-3864
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Glycosides; 0 / Hydroxybenzoates; 0 / Phenols; 120634-86-8 / KS 501
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32. Higgins HJ, Voutsalath M, Holland JM: Muir-torre syndrome: a case report. J Clin Aesthet Dermatol; 2009 Aug;2(8):30-2
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  • [Title] Muir-torre syndrome: a case report.
  • Muir-Torre syndrome is an autosomal dominant genodermatosis associated with sebaceous neoplasms and visceral malignancies.
  • Characteristic sebaceous neoplasms include sebaceous adenoma, sebaceous carcinoma, sebaceoma, and keratoacanthoma with sebaceous differentiation.
  • The clinical and histological features of a patient with Muir-Torre syndrome who had two sebaceous adenomas, multiple basal cell carcinomas, and frontal bossing in association with colon cancer are presented in this report.

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  • (PMID = 20729952.001).
  • [ISSN] 1941-2789
  • [Journal-full-title] The Journal of clinical and aesthetic dermatology
  • [ISO-abbreviation] J Clin Aesthet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923964
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33. Kamat G, Yelikar B, Shettar S, Karigoudar MH: Pigmented trichoblastoma with sebaceous hyperplasia. Indian J Dermatol Venereol Leprol; 2009 Sep-Oct;75(5):506-8
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  • Trichoblastoma is a rare benign trichogenic tumour with epithelial and mesenchymal components recapitulating the germinal hair bulb and associated mesenchyme.
  • Microscopy of tumour revealed nodular tumour spanning the entire dermis with collection of mesenchymal cells resembling follicular papilla.
  • There is a need for differentiation of this tumor which is benign, from other pigmented tumors having basaloid arrangement of cells such as basal cell carcinoma.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Humans. Hyperplasia. Male. Middle Aged. Skin Neoplasms / complications. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19736433.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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34. Fryer SL, Frank LR, Spadoni AD, Theilmann RJ, Nagel BJ, Schweinsburg AD, Tapert SF: Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents. Brain Cogn; 2008 Jul;67(2):225-33
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  • [Title] Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.
  • Fractional anisotropy (FA) and mean diffusion (MD) were evaluated within the splenium and body of the corpus callosum in relation to cognitive performance.
  • RESULTS: Visuospatial construction abilities were associated with white matter integrity in both the splenium and body of the corpus callosum, while only splenium integrity was associated with language and psychomotor function.

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  • (PMID = 18346830.001).
  • [ISSN] 1090-2147
  • [Journal-full-title] Brain and cognition
  • [ISO-abbreviation] Brain Cogn
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / R01 MH064729; United States / NIDA NIH HHS / DA / R21 DA015228; United States / NIAAA NIH HHS / AA / R01 AA013419; United States / NIAAA NIH HHS / AA / T32 AA013525; United States / NIDA NIH HHS / DA / DA15228; United States / NIAAA NIH HHS / AA / AA13419; United States / NIDA NIH HHS / DA / DA021182; United States / NIDA NIH HHS / DA / R01 DA021182-01; United States / NIMH NIH HHS / MH / MH064729; United States / NIDA NIH HHS / DA / R01 DA021182
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS55792; NLM/ PMC2491343
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35. Dutta A, Bhattacharya M, Barat P, Mukherjee P, Gayathri N, Das GC: Lattice resistance to dislocation motion at the nanoscale. Phys Rev Lett; 2008 Sep 12;101(11):115506
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  • In this Letter, we propose a model that demonstrates the effect of a free surface on the lattice resistance experienced by a moving dislocation in nanodimensional systems.
  • To verify this finding, molecular dynamics simulations for an edge dislocation in bcc molybdenum are performed, and the results are found to be in agreement with the numerical implementations of this model.

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  • [CommentIn] Phys Rev Lett. 2010 Aug 27;105(9):099601; author reply 099602 [20868200.001]
  • (PMID = 18851298.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Limtong S, Yongmanitchai W: Candida chanthaburiensis sp. nov., Candida kungkrabaensis sp. nov. and Candida suratensis sp. nov., three novel yeast species from decaying plant materials submerged in water of mangrove forests. Antonie Van Leeuwenhoek; 2010 Oct;98(3):379-88
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  • They were named as Candida chanthaburiensis sp. nov. (type strain EM33(T) = BCC 23057(T) = NBRC 102176(T) = CBS 10926(T)), Candida kungkrabaensis sp. nov. (type strain EM40(T) = BCC 23060(T) = NBRC 102179(T) = CBS 10927(T)), and Candida suratensis sp. nov. (type strain SM56(T) = BCC 25961(T) = NBRC 103858(T) = CBS 10928(T)).

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  • (PMID = 20467812.001).
  • [ISSN] 1572-9699
  • [Journal-full-title] Antonie van Leeuwenhoek
  • [ISO-abbreviation] Antonie Van Leeuwenhoek
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Fungal; 0 / DNA, Ribosomal; 451W47IQ8X / Sodium Chloride
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37. Mills O, Thomas LB: Basaloid follicular hamartoma. Arch Pathol Lab Med; 2010 Aug;134(8):1215-9
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  • Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma.
  • The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal cell carcinoma syndrome.
  • While these hamartomas are considered benign lesions, malignant growths have been reported to arise within them, which raises the question, "Is basaloid follicular hamartoma a premalignant lesion?
  • " Correct identification allows for periodic monitoring for malignant transformation, while sparing patients unnecessary surgery.
  • Treatment strategies, including experimental therapies, are reviewed.
  • [MeSH-major] Hair Diseases / diagnosis. Hair Follicle / pathology. Hamartoma / diagnosis
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Humans. Mutation. Receptors, Cell Surface / genetics. Skin Neoplasms / diagnosis


38. Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M: Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study. BMC Cancer; 2009;9:140
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  • [Title] Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
  • BACKGROUND: Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome).
  • Thus, genetic variants of BLM and proteins that form complexes with BLM, such as TOP3A and RMI1, might affect cancer risk as well.
  • METHODS: In this study we have studied 26 tagged single nucleotide polymorphisms (tagSNPs) in RMI1, TOP3A, and BLM and their associations with cancer risk in acute myeloid leukemia/myelodysplatic syndromes (AML/MDS; N = 152), malignant melanoma (N = 170), and bladder cancer (N = 61).
  • RESULTS: Based on consistency in effect estimates for the three cancer forms and similar allelic frequencies of the variant alleles in the control groups, two SNPs in TOP3A (rs1563634 and rs12945597) and two SNPs in BLM (rs401549 and rs2532105) were selected for analysis in breast cancer cases (N = 200) and a control group recruited from spouses of cancer patients (N = 131).
  • The rs12945597 in TOP3A and rs2532105 in BLM showed increased risk for breast cancer.
  • We then combined all cases (N = 584) and controls (N = 406) respectively and found significantly increased risk for variant carriers of rs1563634 A/G (AG carriers OR = 1.7 [95%CI 1.1-2.6], AA carriers OR = 1.8 [1.2-2.8]), rs12945597 G/A (GA carriers OR = 1.5 [1.1-1.9], AA carriers OR = 1.6 [1.0-2.5]), and rs2532105 C/T (CT+TT carriers OR = 1.8 [1.4-2.5]).
  • CONCLUSION: These results further support a role of low-penetrance genes involved in BLM-associated homologous recombination for cancer risk.
  • [MeSH-major] Carrier Proteins / genetics. DNA Topoisomerases, Type I / genetics. Genetic Predisposition to Disease. Neoplasms / genetics. Nuclear Proteins / genetics. Polymorphism, Single Nucleotide. RecQ Helicases / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. European Continental Ancestry Group / genetics. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19432957.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Nuclear Proteins; 0 / RMI1 protein, human; EC 3.6.1.- / Bloom syndrome protein; EC 3.6.4.12 / RecQ Helicases; EC 5.99.1.2 / DNA Topoisomerases, Type I; EC 5.99.1.2 / DNA topoisomerase III
  • [Other-IDs] NLM/ PMC2685436
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39. Blokhuis MM, Goldberg PA, Pietersen GE, Algar U, Vorster AA, Govender D, Ramesar RS: The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation. Fam Cancer; 2008;7(3):191-8
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  • [Title] The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation.
  • Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, characterized by the occurrence of predominantly colon and endometrial cancer and, less frequently, cancer of the small bowel, stomach, hepatobiliary tract, ureter, renal pelvis, ovaries and brain.
  • The aim of this study was to investigate the frequency of extracolonic cancers in a cohort of females sharing the same c.C1528T disease-predisposing mutation in the hMLH1 gene.
  • Data on cancer history were obtained from 87 mutation-positive females and 121 mutation-negative sisters, as a control group.
  • Testing for microsatellite instability (MSI) and expression of the wild-type hMLH1 allele was performed on extra-colonic tumour tissue blocks of mutation-positive individuals.
  • Extracolonic cancer occurred in 14% (12/87) of mutation-positive females vs. 7% (8/121) of mutation-negative females (P = 0.10).
  • Breast cancer, which was the most frequent extra-colonic cancer in mutation positive females (53%), occurred at a young age, and occurred bilaterally in two out of seven cases.
  • Involvement of the hMLH1 gene was confirmed in five out of seven cases of breast cancer, two cases of endometrial cancer, one case of ovarian cancer and one case of renal cell carcinoma, by detecting immunohistochemical compromise of the gene product.
  • Although the study might not have been adequately statistically powered (to provide a significant P value), the noteworthy findings in this study include the confirmation of a range of Lynch II type cancers in a cohort we previously thought was wholly predisposed to Lynch I features, and a confirmation of breast cancer as part of the spectrum of Lynch syndrome cancers affecting women.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Mutation. Neoplasms / epidemiology. Neoplasms / genetics. Nuclear Proteins / genetics
  • [MeSH-minor] Adult. Alleles. Case-Control Studies. Cohort Studies. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Cysteine. Female. Genetic Predisposition to Disease. Humans. Incidence. Microsatellite Instability. Middle Aged. MutL Protein Homolog 1. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / genetics. Phenotype. Population Surveillance. Risk Factors. Sex Factors. Siblings. South Africa / epidemiology. Threonine

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  • (PMID = 18049911.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 2ZD004190S / Threonine; EC 3.6.1.3 / MutL Protein Homolog 1; K848JZ4886 / Cysteine
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40. Pylkäs K, Tommiska J, Syrjäkoski K, Kere J, Gatei M, Waddell N, Allinen M, Karppinen SM, Rapakko K, Kääriäinen H, Aittomäki K, Blomqvist C, Mustonen A, Holli K, Khanna KK, Kallioniemi OP, Nevanlinna H, Winqvist R: Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. Carcinogenesis; 2007 May;28(5):1040-5
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  • [Title] Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
  • Studies on A-T families have shown that obligate female carriers have increased risk of developing breast cancer.
  • Here we have evaluated the role of known Finnish ATM germ line mutations as possible breast cancer predisposing alleles outside A-T families by analyzing their prevalence in large cohorts of familial and unselected breast cancer cases.
  • Of seven different alterations, two were observed in the studied breast cancer material.
  • ATM 6903insA (causing protein truncation) was seen in 3/541 familial and 5/1124 unselected cases, but not among healthy population controls (0/1107).
  • 7570G>C (Ala2524Pro) occurred in 1/541 familial and 2/1124 unselected cases compared with 1/1107 in controls.
  • Additionally, 8734A>G (Arg2912Gly) associated previously with breast cancer susceptibility and suggested to be causative also for A-T was detected in 2/541 of familial cases, but not in unselected cases (0/1124) or controls (0/1107).
  • In total, heterozygous ATM mutation carriers were observed in 6/541 familial [P = 0.006, odds ratio (OR) 12.4, 95% confidence interval (CI) 1.5-103.3) and 7/1124 unselected cases (P = 0.07, OR 6.9, 95% CI 0.9-56.4), compared with 1/1107 in controls, suggesting an apparent yet overall limited contribution to predisposition to cancer.
  • Interestingly, results from functional analysis of the breast cancer-associated ATM mutations indicated that cancer susceptibility is not restricted to mutations with dominant-negative effect on kinase activity, displayed only by 7570G>C, whereas 8734A>G showed only a partial defect in the phosphorylation of ATM substrates, and 6903insA seemed to be a null allele.
  • [MeSH-major] Ataxia Telangiectasia / genetics. Breast Neoplasms / genetics. Cell Cycle Proteins / physiology. DNA-Binding Proteins / physiology. Genetic Predisposition to Disease. Mutation. Protein-Serine-Threonine Kinases / physiology. Tumor Suppressor Proteins / physiology


41. Tassone P, Blotta S, Palmieri C, Masciari S, Quaresima B, Montagna M, D'Andrea E, Eramo OP, Migale L, Costanzo F, Tagliaferri P, Venuta S: Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents. Int J Oncol; 2005 May;26(5):1257-63
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  • [Title] Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents.
  • Germ-line mutations in the breast cancer susceptibility BRCA1 gene account for approximately half of hereditary breast cancer cases and most of breast/ovarian cancer cases.
  • We speculated whether breast hereditary cancers might be differentially sensitive to antitumor agents such as the mitotic spindle poisons Vinca alcaloid vinorelbine (VNR) and the taxoid docetaxel (DOC), which are commonly used in the treatment of breast cancer.
  • We investigated the sensitivity of the BRCA1-mutated HCC1937 (derived from a BRCA1 related hereditary tumor) and BRCA1 competent MCF-7 and MDA-MB468 sporadic breast cancer cell lines to these drugs.
  • Instead, BRCA1-mutated breast cancer cells exposed to DOC showed similar sensitivity as compared to BRCA1-competent MCF-7 or were less sensitive than MDA-MB468.
  • Moreover, VNR induced apoptotic cell death and cytoskeletal rearrangements in HCC1937 cells.
  • We further investigated whether a defective targeting of mitotic spindle by the mutated BRCA1 gene product might be involved in the differential sensitivity to VNR.
  • In conclusion, our data suggest that BRCA1-mutated tumors might be differentially sensitive to anti-microtubule agents, supporting the rationale for clinical trials to improve the outcome of hereditary breast cancer patients by tailored treatments.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / pharmacology. Breast Neoplasms / genetics. Genes, BRCA1. Taxoids / pharmacology. Vinblastine / analogs & derivatives. Vinblastine / pharmacology
  • [MeSH-minor] Apoptosis. Cytoskeleton / pathology. DNA Mutational Analysis. Drug Resistance, Neoplasm. Female. Germ-Line Mutation. Humans. Microtubules / pathology. Spindle Apparatus / pathology. Tumor Cells, Cultured

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  • (PMID = 15809716.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 5V9KLZ54CY / Vinblastine; Q6C979R91Y / vinorelbine
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42. Anehosur V: Gorlin's syndrome - Report of a case and management of cystic lesions. J Maxillofac Oral Surg; 2009 Jun;8(2):184-7
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  • [Title] Gorlin's syndrome - Report of a case and management of cystic lesions.
  • It is characterized by cutaneous basal cell carcinomas, multiple keratocysts in the jaw bones and skeletal anomalies.
  • A case is presented with multiple odontogenic keratocyst and dentigerous cysts occurring in all quadrants of oral cavity with features suggestive of Gorlin's Syndrome.

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  • [Cites] Lancet. 1992 Mar 7;339(8793):581-2 [1347096.001]
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  • (PMID = 23139503.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453930
  • [Keywords] NOTNLM ; Carcinoma / Dentigerous cyst / Keratocyst / Nevoid
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43. Perrin MC, Terry MB, Kleinhaus K, Deutsch L, Yanetz R, Tiram E, Calderon-Margalit R, Friedlander Y, Paltiel O, Harlap S: Gestational diabetes and the risk of breast cancer among women in the Jerusalem Perinatal Study. Breast Cancer Res Treat; 2008 Mar;108(1):129-35
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  • [Title] Gestational diabetes and the risk of breast cancer among women in the Jerusalem Perinatal Study.
  • Gestational diabetes is becoming increasingly common; it is important to determine how it relates to future risk of disease.
  • We investigated the relation of gestational diabetes to breast cancer in 37,926 women who had one or more live births in 1964-1976 for whom information had been collected on complications of pregnancy.
  • In this cohort there were 1,626 cases of breast cancer reported to the Israel Cancer Registry before January 1, 2005 and 410 cases of gestational diabetes recorded from birth records.
  • There were 29 cases of breast cancer among women diagnosed with gestational diabetes.
  • Using Cox proportional hazards models to control for age and birth order at the first observed birth and other characteristics, we found that the incidence of breast cancer was increased among women diagnosed with gestational diabetes (relative rate = 1.5, 95% confidence interval 1.0-2.1).
  • The findings suggest that gestational diabetes may be an important early marker of breast cancer risk among post-menopausal women, but these results need to be confirmed in future studies.
  • [MeSH-major] Breast Neoplasms / epidemiology. Diabetes, Gestational / epidemiology

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  • (PMID = 17476589.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 80197
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
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44. Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Kirkali Z, Montironi R: Rare and unusual histological variants of prostatic carcinoma: clinical significance. BJU Int; 2008 Nov;102(10):1369-74
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  • [Title] Rare and unusual histological variants of prostatic carcinoma: clinical significance.
  • We review the clinicopathological features of the following unusual histological variants of prostatic carcinoma: small cell carcinoma, ductal adenocarcinoma, sarcomatoid (carcinosarcoma), basal cell, squamous cell and adenosquamous, and urothelial carcinoma.
  • These variants are rare and account for 5-10% of carcinomas that originate in the prostate.
  • Only basal cell carcinoma is seen as a low-grade carcinoma.
  • [MeSH-major] Prostatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Carcinosarcoma / pathology. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 18793296.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 56
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45. Tallón-Walton V, Nieminen P, Arte S, Ustrell-Torrent JM, Carvalho-Lobato P, Manzanares-Céspedes MC: Oral findings in Midline Syndrome: a case report and literature review. Med Oral Patol Oral Cir Bucal; 2010 Jul;15(4):e579-82
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  • [Title] Oral findings in Midline Syndrome: a case report and literature review.
  • The patient presents agenesis of the corpus callosum, encephalocele, iris coloboma, hypertelorism, submucosal cleft palate and dental anomalies.
  • [MeSH-major] Agenesis of Corpus Callosum. Cleft Palate. Coloboma. Encephalocele. Hypertelorism. Iris / abnormalities. Tooth Abnormalities
  • [MeSH-minor] Abnormalities, Multiple / diagnosis. Child. Female. Humans. Phenotype. Syndrome

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  • (PMID = 20173721.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
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46. DeAmbrosis K, Nicklin J, Yong-Gee S: Basal cell carcinoma of the vulva: a report of four cases. Australas J Dermatol; 2008 Nov;49(4):213-5
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  • [Title] Basal cell carcinoma of the vulva: a report of four cases.
  • Four cases of vulval basal cell carcinoma were identified in multiparous females aged 46-78 years.
  • Such symptoms occurred in the context of a pink vulval plaque.
  • Subsequent treatment in all cases involved wide local excision following incisional biopsy.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Vulvar Neoplasms / diagnosis. Vulvar Neoplasms / surgery
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Middle Aged. Pruritus Vulvae / etiology. Treatment Outcome. Vulvar Lichen Sclerosus / diagnosis

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  • [CommentIn] Australas J Dermatol. 2009 Nov;50(4):297; author reply 297-8 [19916978.001]
  • (PMID = 18855783.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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47. Varga Z, Mallon E: Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls. Breast Dis; 2008-2009;30:15-9
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  • [Title] Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls.
  • Invasive lobular carcinomas (ILC) represent the most common subtype of invasive breast cancer and account for about 5-15% of all breast cancer cases.
  • Invasive lobular carcinoma is often accompanied by in situ lesions, by lobular neoplasia (LN).
  • Invasive lobular carcinomas display diverse histologic patterns varying from classical through solid to pleomorphic subtypes.
  • The majority of invasive lobular carcinomas are hormone receptor positive, overexpression and/or amplification of the Her2 gene is lower than in carcinomas of invasive ductal type.
  • Loss of heterozygosity of the 16q chromosomal regions and the consequent lack of E-Cadherin expression are common findings in invasive lobular carcinomas.
  • Intra-operative evaluation of resection margins in ILC is often unsatisfactory due to the diffuse nature of the tumor.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Lobular / pathology
  • [MeSH-minor] Carcinoma, Ductal, Breast / immunology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasm Grading. Prognosis


48. Cheng CY, Mei HC, Tsao CF, Liao YR, Huang HH, Chung YC: Diversity of the bacterial community in a bioreactor during ammonia gas removal. Bioresour Technol; 2010 Jan;101(1):434-7
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  • Polymerase chain reaction analysis in combination with denaturing gradient gel electrophoresis (DGGE) was used to determine changes in the composition of the bacterial community of a bioreactor during ammonia removal.
  • However, the occurrence and predominance of specific bacterial species varied with the concentrations of NH(3) introduced into the bioreactor.
  • The complexity of the bacterial species generally decreased with increasing inlet NH(3) concentration.
  • The strains identified in this study are potential candidate strains for the purification of waste gases containing high concentrations of NH(3).

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  • (PMID = 19716695.001).
  • [ISSN] 1873-2976
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases; 0 / Industrial Waste; 7664-41-7 / Ammonia
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49. Snarskaia ES, Suchkov SV, Molochkov VA: [Modern programs of treatment and rehabilitation of patients with basaliomas: their pathogenic substantiation and clinical effectiveness]. Vestn Ross Akad Med Nauk; 2005;(6):41-5
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  • [Title] [Modern programs of treatment and rehabilitation of patients with basaliomas: their pathogenic substantiation and clinical effectiveness].
  • With the aim of forming modern programs for immunogenetic therapy of epithelial tumors, such as methatypic and basal cell carcinomas, the authors of the article analyze the basics of their immunopathogenesis.

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  • (PMID = 16022112.001).
  • [ISSN] 0869-6047
  • [Journal-full-title] Vestnik Rossiiskoi akademii meditsinskikh nauk
  • [ISO-abbreviation] Vestn. Akad. Med. Nauk SSSR
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Cancer Vaccines; 0 / HLA-DR Antigens
  • [Number-of-references] 44
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50. Brekelmans CT, Tilanus-Linthorst MM, Seynaeve C, vd Ouweland A, Menke-Pluymers MB, Bartels CC, Kriege M, van Geel AN, Burger CW, Eggermont AM, Meijers-Heijboer H, Klijn JG: Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases. Eur J Cancer; 2007 Mar;43(5):867-76
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  • [Title] Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases.
  • AIM OF THE STUDY: Results on tumour characteristics and survival of hereditary breast cancer (BC), especially on BRCA2-associated BC, are inconclusive.
  • The prognostic impact of the classical tumour and treatment factors in hereditary BC is insufficiently known.
  • METHODS: We selected 103 BRCA2-, 223 BRCA1- and 311 non-BRCA1/2 BC patients (diagnosis 1980-2004) from the Rotterdam Family Cancer Clinic.
  • To correct for longevity bias, analyses were also performed while excluding index patients undergoing DNA testing 2 years after BC diagnosis.
  • As a comparison group, 759 sporadic BC patients of comparable age at and year of diagnosis were selected.
  • We compared tumour characteristics, the occurrence of ipsilateral recurrence (LRR) and contralateral BC (CBC) as well as distant disease-free (DDFS), BC-specific (BCSS) and overall survival (OS) between these groups.
  • By multivariate modelling, the prognostic impact of tumour and treatment factors was investigated separately in hereditary BC.
  • In contrast, tumour characteristics of BRCA2-associated BC were similar to those of non-BRCA1/2 and sporadic BC, with the exception of a high risk of CBC (3.1% per year) and oestrogen-receptor (ER)-positivity (83%).
  • Independent prognostic factors for BC-specific survival in hereditary BC (combining the three subgroups) were tumour stage, adjuvant chemotherapy, histologic grade, ER status and a prophylactic (salpingo-)oophorectomy.
  • Our observation that tumour size and nodal status are prognostic factors also in hereditary BC implies that the strategy to use these factors as a proxy for ultimate mortality appears to be valid also in this specific group of patients.
  • [MeSH-major] Breast Neoplasms / genetics. Genes, BRCA1. Genes, BRCA2
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Cohort Studies. DNA, Neoplasm / analysis. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / mortality. Pedigree. Prognosis


51. de Feraudy S, Boubakour-Azzouz I, Fraitag S, Berneburg M, Chan L, Chew K, Clericuzio CL, Cunningham B, Tope WD, Cleaver JE: Diagnosing xeroderma pigmentosum group C by immunohistochemistry. Am J Dermatopathol; 2010 Apr;32(2):109-17
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  • To determine whether immunohistochemistry (IHC) would be a robust alternative method to diagnose patients with XPC, we stained sections of paraffin-embedded skin biopsies for XPC by IHC, using 69 archived blocks from confirmed or clinically suspect patients with XPA, XPC, XPD, XPE, and without XP.
  • We found that XPC expression was strong in all skin biopsies from patients without (14 of 14) and other patients with XP (4 of 4), whereas XPC expression was lost in all biopsies from confirmed XPC patients (29 of 29).
  • Patches of strong XPC signal could be detected in sun-damaged skin, squamous and basal cell carcinomas from patients with XPC that colocalized with strong expression of p53 and Ki-67.
  • Patients with XPC can therefore be diagnosed by IHC from paraffin-embedded skin biopsies from regions of skin that are without sun damage or sun-induced tumors.
  • This fast and inexpensive method should increase the options for the diagnosis of patients with XPC from paraffin-embedded skin biopsies and could be developed for other complementation groups.
  • [MeSH-major] Immunohistochemistry / methods. Xeroderma Pigmentosum / classification. Xeroderma Pigmentosum / diagnosis
  • [MeSH-minor] Biopsy. DNA-Binding Proteins / metabolism. Humans. Ki-67 Antigen / metabolism. Lymphocytes / metabolism. Lymphocytes / pathology. Paraffin Embedding. Skin / metabolism. Skin / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19915453.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / 1R01NS052781; United States / NIAMS NIH HHS / AR / P01 AR050440
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 156533-34-5 / XPC protein, human
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52. Salas A, Vega A, Milne RL, García-Magariños M, Ruibal A, Benítez J, Carracedo A: The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer. Clin Med Oncol; 2008;2:357-62
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  • [Title] The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer.
  • It has been proposed that the excess of familiar risk associated with breast cancer could be explained by the cumulative effect of multiple weakly predisposing alleles.
  • Here we aimed to determine whether polymorphisms in ZBTB7 are associated with breast cancer risk in a sample of cases and controls collected in hospitals from North and Central Spanish patients.
  • We genotyped 15 SNPs in ZBTB7, including the flanking regions, with an average coverage of 1 SNP/2.4 Kb, in 360 sporadic breast cancer cases and 402 controls.
  • Comparison of allele, genotype and haplotype frequencies between cases and controls did not reveal associations using Pearson's chi-square test and a permutation procedure to correct for multiple test.
  • In this, the first study of the ZBTB7 gene in relation to, sporadic breast cancer, we found no evidence of an association.

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  • (PMID = 21892298.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3161631
  • [Keywords] NOTNLM ; POKEMON / ZBTB7 / association study / breast cancer / case-control
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53. Choi DH, Cho DY, Lee MH, Park HS, Ahn SH, Son BH, Haffty BG: The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation. Breast Cancer Res Treat; 2008 Dec;112(3):569-73
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  • [Title] The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.
  • The germline CHEK2 1100delC mutation is a low penetrance breast cancer susceptibility allele, frequently observed in patient with family history of breast cancer and/or young age and the frequency varied according to race or ethnicity.
  • In this study, we evaluated the significance of CHEK2 1100delC in predisposition to breast cancer by assessing its frequency in a material of 493 Korean breast cancer patients who had been screened for BRCA1 and BRCA2 mutations (42 patients had deleterious mutation of BRCA1/2).
  • None of the 493 Korean patients with breast cancer who were candidate for BRCA1 and BRCA2 test carried the 1100delC mutation observed in Caucasians with limited frequency.
  • In the previous studies, we observed higher or comparable prevalence of BRCA1 and BRCA2 mutations in Korean patients with breast cancer compared to Caucasian breast cancer population.
  • In the present study, we evaluated the role of a CHEK2 1100delC as a susceptibility mutation of breast cancer in the Korean population.
  • However, our results suggest that this mutation is absent or may be very infrequent in Korean patients with breast cancer who have high risk of BRCA1 and BRCA2 mutation, making its screening irrelevant from the practical point view.
  • [MeSH-major] Breast Neoplasms / genetics. Genes, BRCA1. Genes, BRCA2. Mutation. Protein-Serine-Threonine Kinases / genetics

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  • (PMID = 18175216.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.7.1.11 / Checkpoint Kinase 2; EC 2.7.11.1 / CHEK2 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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54. Gowda S, Tillman DK, Fitzpatrick JE, Gaspari AA, Goldenberg G: Imiquimod-induced vitiligo after treatment of nodular basal cell carcinoma. J Cutan Pathol; 2009 Aug;36(8):878-81
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  • [Title] Imiquimod-induced vitiligo after treatment of nodular basal cell carcinoma.
  • An 84-year-old male presented with recurrent nodular infiltrative basal cell carcinoma on the left shoulder.
  • The adjacent unaffected skin showed a normal number of melanocytes and melanin pigment.
  • To our knowledge, this is the first biopsy-proven case of vitiligo in an imiquimod-treated area.
  • [MeSH-major] Aminoquinolines / adverse effects. Antineoplastic Agents / adverse effects. Carcinoma, Basal Cell / drug therapy. Skin Neoplasms / drug therapy. Vitiligo / chemically induced. Vitiligo / pathology
  • [MeSH-minor] Aged, 80 and over. Humans. Male. Melanocytes / pathology. Skin / pathology. Time Factors

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  • (PMID = 19586497.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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55. Wiseman RL, Green NS, Kelly JW: Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry; 2005 Jun 28;44(25):9265-74
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  • Therefore, small molecule-mediated kinetic stabilization of the native state is an attractive strategy to prevent the misfolding and misassembly associated with TTR amyloid disease.
  • Small molecule kinetic stabilization of TTR has been established by concentration-dependent inhibition of acid-mediated amyloidogenesis and urea-induced tetramer dissociation.
  • Addition of amyloidogenesis inhibitors to this exchange reaction slows tetramer dissociation in a concentration-dependent manner, stopping dissociation at concentrations where at least one inhibitor is bound to each tetramer in solution.
  • Subunit exchange enables the rate of tetramer dissociation and the kinetic stabilization imparted by small molecule binding to be evaluated under physiological conditions in which the TTR concentration is not reduced by aggregation or irreversible dissociation.
  • [MeSH-minor] Kinetics. Molecular Structure. Protein Binding. Protein Denaturation. Protein Structure, Quaternary. Protein Subunits / antagonists & inhibitors. Protein Subunits / chemistry. Protein Subunits / genetics. Protein Subunits / metabolism. Thermodynamics

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  • (PMID = 15966751.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK060304-03; United States / NIDDK NIH HHS / DK / DK46335
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prealbumin; 0 / Protein Subunits
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56. Wettstein R, Erba P, Farhadi J, Kalbermatten DF, Arnold A, Haug M, Pierer G: Incomplete excision of basal cell carcinoma in the subunits of the nose. Scand J Plast Reconstr Surg Hand Surg; 2008;42(2):92-5
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  • [Title] Incomplete excision of basal cell carcinoma in the subunits of the nose.
  • Reconstructive procedures after resection of nasal basal cell carcinoma (BCC) vary depending on the subunit involved.
  • The aim of the present study was to assess the influence of the location of the BCC on the rate of incomplete excisions, so we made a retrospective analysis of all nasal BCC excised at our hospital between 2002 and 2005.
  • BCC were most likely to be incompletely excised on the nasal tip and alae, and both subunits required more elaborate reconstructions.
  • This, however, was not the result of poor estimation of the extent of the tumour and reluctance to excise more challenging areas widely for reconstruction, but to the method chosen to eradicate the tumour.

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  • (PMID = 18335353.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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57. Ly E, Piot O, Durlach A, Bernard P, Manfait M: Differential diagnosis of cutaneous carcinomas by infrared spectral micro-imaging combined with pattern recognition. Analyst; 2009 Jun;134(6):1208-14
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  • [Title] Differential diagnosis of cutaneous carcinomas by infrared spectral micro-imaging combined with pattern recognition.
  • Non-melanoma skin cancer includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Bowen's disease.
  • The differential diagnosis of these lesions is sometimes difficult and relies on the histopathological examination of surgical specimens.
  • However, a precise differential diagnosis is crucial for an accurate therapy and thus better patient care.
  • FTIR spectral micro-imaging was applied directly on formalin-fixed paraffin-embedded samples of non-melanoma skin cancers.
  • High correlation was obtained between the prediction maps and the histology which proves the great potential of FTIR spectroscopy for the differential diagnosis of skin carcinomas.
  • [MeSH-major] Pattern Recognition, Automated. Skin Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Discriminant Analysis. Eccrine Glands / pathology. Hair Follicle / pathology. Humans. Image Interpretation, Computer-Assisted. Principal Component Analysis. Reproducibility of Results. Sebaceous Glands / pathology. Spectroscopy, Fourier Transform Infrared

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  • (PMID = 19475150.001).
  • [ISSN] 1364-5528
  • [Journal-full-title] The Analyst
  • [ISO-abbreviation] Analyst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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58. Ramos-Ceballos FI, Pashaei S, Kincannon JM, Morgan MB, Smoller BR: Bcl-2, CD34 and CD10 expression in basaloid follicular hamartoma, vellus hair hamartoma and neurofollicular hamartoma demonstrate full follicular differentiation. J Cutan Pathol; 2008 May;35(5):477-83
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  • Generalized basaloid follicular hamartoma syndrome (GBFHS) is a rare, recently-described, autosomal-dominantly inherited disorder that presents with disseminated milia, palmoplantar pitting, hypotrichosis and basaloid follicular hamartomas (BFH).
  • BFH is a benign adnexal tumor that resembles basal cell carcinoma (BCC).
  • In this study, we report two cases of GBFHS and stain BFH, a vellus hair hamartoma (VHH) and a neurofollicular hamartoma (NH) with CD34, bcl-2 and CD10 to characterize and compare the staining patterns of these follicular tumors.
  • Bcl-2 stained the outermost cell layers of the basaloid nests in all specimens.
  • Bcl-2 stains the outermost cell layer of these tumors.
  • These results show the similarities in differentiation between these benign follicular neoplasms and trichoepithelioma.

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  • [CommentIn] J Cutan Pathol. 2009 May;36(5):603; author reply 604 [19476535.001]
  • (PMID = 18399809.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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59. Haanpää M, Reiman M, Nikkilä J, Erkko H, Pylkäs K, Winqvist R: Mutation analysis of the AATF gene in breast cancer families. BMC Cancer; 2009;9:457
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  • [Title] Mutation analysis of the AATF gene in breast cancer families.
  • BACKGROUND: About 5-10% of breast cancer is due to inherited disease predisposition.
  • AATF plays an important role in the regulation of gene transcription and cell proliferation.
  • Based on its biological function, and direct interaction with several known breast cancer risk factors, AATF is a good candidate gene for being involved in heritable cancer susceptibility.
  • METHODS: Here we have screened the entire coding region of AATF in affected index cases from 121 Finnish cancer families for germline defects, using conformation sensitive gel electrophoresis and direct sequencing.
  • Based on the in silico analyses of these sequence alterations, as well as their occurrence in cases and controls, none of them, however, were predicted to be pathogenic.
  • CONCLUSIONS: To our knowledge, this is the first study reporting the mutation screening of the AATF gene in familial breast cancer cases.
  • No evidence for the association with breast cancer was observed.
  • [MeSH-major] Apoptosis Regulatory Proteins / genetics. Breast Neoplasms / genetics. Family. Repressor Proteins / genetics
  • [MeSH-minor] DNA Mutational Analysis. Female. Finland. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Mutation, Missense. Polymorphism, Single Nucleotide

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  • (PMID = 20025740.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AATF protein, human; 0 / Apoptosis Regulatory Proteins; 0 / Repressor Proteins
  • [Other-IDs] NLM/ PMC2806411
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60. Güth U, Huang DJ, Schötzau A, Dirnhofer S, Wight E, Singer G: Breast cancer with non-inflammatory skin involvement: current data on an underreported entity and its problematic classification. Breast; 2010 Feb;19(1):59-64
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  • [Title] Breast cancer with non-inflammatory skin involvement: current data on an underreported entity and its problematic classification.
  • We evaluated 166 breast cancer cases with non-inflammatory skin involvement (NISI), which were classified in the TNM classification as T4b.
  • The distribution of tumour sizes and stages was: < or =3 cm:24.1%, 3.1-5 cm:21.7%, 5.1-10 cm:33.1%, >10 cm:21.1%; stages:I/II:21.0%, III:43.4%, IV:35.6%.
  • According to the inherent rules of tumour classification, only tumours with similar morphologic extent and prognostic significance should be combined.
  • Since there is a high grade of heterogeneity, this basic tenet is clearly violated regarding breast cancer with NISI.
  • [MeSH-major] Breast Neoplasms / classification. Breast Neoplasms / pathology. Neoplasm Staging / classification. Skin Neoplasms / classification. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged. Prognosis. Retrospective Studies. Risk Factors. Switzerland. Women's Health


61. Maskarinec G, Erber E, Verheus M, Hernandez BY, Killeen J, Cashin S, Cline JM: Soy consumption and histopathologic markers in breast tissue using tissue microarrays. Nutr Cancer; 2009;61(5):708-16
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  • [Title] Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
  • This study examined the relation of soy intake with hormonal and proliferation markers in benign and malignant breast tissue using tissue microarrays (TMAs).
  • TMAs with up to 4 malignant and 4 benign tissue samples for 268 breast cancer cases were constructed.
  • The TMAs were stained for estrogen receptor (ER) alpha, ERbeta, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu), proliferating cell nuclear antigen (PCNA), and Ki-67 using standard immunohistochemical methods.
  • A higher percentage of women showed positive marker expression in malignant than in benign tissue.
  • Early life soy intake was associated with lower HER2/neu and PCNA staining of malignant tissue.
  • In benign tissue, early life soy intake showed higher ER and PR expression, but no difference in proliferation markers.

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  • (PMID = 19838945.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA085265-03; United States / NCI NIH HHS / CA / R21 CA100250; United States / NCI NIH HHS / CA / R21 CA1080250; United States / NCI NIH HHS / CA / CA108250-02; United States / NCI NIH HHS / CA / R21 CA108250; United States / NCI NIH HHS / CA / R01 CA85265; United States / NCI NIH HHS / CA / CA085265-03; United States / NCI NIH HHS / CA / R37 CA054281-17; United States / NCI NIH HHS / CA / R01 CA085265; United States / NCI NIH HHS / CA / CA054281-17; United States / NCI NIH HHS / CA / R37 CA054281; United States / NCI NIH HHS / CA / R37 CA 54281; United States / NCI NIH HHS / CA / R21 CA108250-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS215718; NLM/ PMC2903450
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62. Monroe KR, Murphy SP, Kolonel LN, Pike MC: Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study. Br J Cancer; 2007 Aug 6;97(3):440-5
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  • [Title] Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study.
  • There is evidence that grapefruit, an inhibitor of CYP3A4, increases plasma oestrogen concentrations.
  • Since it is well established that oestrogen is associated with breast cancer risk, it is plausible that regular intake of grapefruit would increase a woman's risk of breast cancer.
  • We investigated the association of grapefruit intake with breast cancer risk in the Hawaii-Los Angeles Multiethnic Cohort Study, a prospective cohort that includes over 50 000 postmenopausal women from five racial/ethnic groups.
  • A total of 1657 incident breast cancer cases were available for analysis.
  • Grapefruit intake was significantly associated with an increased risk of breast cancer (relative risk=1.30, 95% confidence interval 1.06-1.58) for subjects in the highest category of intake, that is, one-quarter grapefruit or more per day, compared to non-consumers (P(trend)=0.015).
  • Grapefruit intake may increase the risk of breast cancer among postmenopausal women.

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  • (PMID = 17622247.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R37 CA054281; United States / NCI NIH HHS / CA / R37 CA54281
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.13.67 / CYP3A4 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A
  • [Other-IDs] NLM/ PMC2360312
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63. Weiss JR, Moysich KB, Swede H: Epidemiology of male breast cancer. Cancer Epidemiol Biomarkers Prev; 2005 Jan;14(1):20-6
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  • [Title] Epidemiology of male breast cancer.
  • Breast cancer in men is a rare disease, accounting for approximately 1% of all breast cancer cases.
  • Although the epidemiologic literature regarding female breast cancer is extensive, relatively little is known about the etiology of male breast cancer (MBC).
  • This review is intended to summarize the existing body of evidence on genetic and epidemiologic risk factors for breast cancer in men.
  • Overall, the epidemiology of MBC presents similarities with the epidemiology of female breast cancer.
  • Major genetic factors associated with an increased risk of breast cancer for men include BRCA2 mutations, which are believed to account for the majority of inherited breast cancer in men, Klinefelter syndrome, and a positive family history.
  • Suspected epidemiologic risk factors include prostate cancer,prostate cancer treatment, gynecomastia, occupational exposures (e.g., electromagnetic fields, polycyclic aromatic hydrocarbons, and high temperatures), dietary factors (e.g., meat intake and fruit and vegetable consumption), and alcohol intake.
  • [MeSH-major] Breast Neoplasms, Male / epidemiology
  • [MeSH-minor] Biomarkers, Tumor. Diet. Environmental Exposure. Estrogens / metabolism. Genes, BRCA2. Genetic Predisposition to Disease. Gynecomastia / complications. Humans. Klinefelter Syndrome / genetics. Male. Mutation. Risk Factors. Testicular Diseases / complications

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  • (PMID = 15668471.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Estrogens
  • [Number-of-references] 126
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64. El Demellawy D, Escott N, Salama S, Alowami S: Sebaceoma of the external ear canal: an unusual location. Case report and review of the literature. J Cutan Pathol; 2008 Oct;35(10):963-6
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  • [Title] Sebaceoma of the external ear canal: an unusual location. Case report and review of the literature.
  • Sebaceous neoplasms of the external ear canal are extremely rare.
  • Only two cases of sebaceous neoplasms have been reported in the English literature, a sebaceous carcinoma and a sebaceous adenoma.
  • We report a case of sebaceoma of the external ear canal.
  • We highlight the differential diagnosis, particularly sebaceous carcinoma and basal cell carcinoma with sebaceous differentiation.
  • Awareness of the possible occurrence of sebaceoma in the auditory canal may prevent the diagnostic pitfall of misidentifying this tumor.
  • [MeSH-major] Ear Canal / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18564279.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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65. Ducic Y, Marra DE, Kennard C: Initial Mohs surgery followed by planned surgical resection of massive cutaneous carcinomas of the head and neck. Laryngoscope; 2009 Apr;119(4):774-7
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  • [Title] Initial Mohs surgery followed by planned surgical resection of massive cutaneous carcinomas of the head and neck.
  • OBJECTIVE: To review our experience with Mohs excision of massive cutaneous carcinomas for peripheral margin control, followed by planned definitive resection of the deeply invasive component of the carcinoma.
  • METHODS: All cases of massive (at least 10 cm in dimension) cutaneous carcinomas treated by the technique outlined by Yadranko Ducic from 1998-2006.
  • RESULTS: A total of 28 cases (7 squamous cell carcinomas, 14 basal cell carcinomas, 7 basosquamous carcinomas) were treated in this manner.
  • Average maximal tumor dimension was 12.7 cm with a range of 10-21 cm.
  • There were a total of 7 local recurrences (5 squamous cell carcinoma and 2 basal cell carcinoma).
  • CONCLUSIONS: The technique appears to be an excellent means of treatment of massive, neglected, and deeply invasive cutaneous carcinomas of the face and neck.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Basosquamous / surgery. Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / surgery. Mohs Surgery / methods. Neoplasm Recurrence, Local / surgery. Skin Neoplasms / surgery

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  • (PMID = 19205010.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Decara JM, Aguilera J, Abdala R, Sánchez P, Figueroa FL, Herrera E: Screening of urocanic acid isomers in human basal and squamous cell carcinoma tumors compared with tumor periphery and healthy skin. Exp Dermatol; 2008 Oct;17(10):806-12
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  • [Title] Screening of urocanic acid isomers in human basal and squamous cell carcinoma tumors compared with tumor periphery and healthy skin.
  • This immunomodulation has been recognized as an important factor related to skin cancer development.
  • This is the first time that UCA isomers have been measured in epidermis of skin biopsies from patients with squamous cell carcinoma (SCC) and with basal cell carcinoma (BCC) and compared with the tumor periphery and biopsies of healthy photoexposed and non-photoexposed skin as controls.
  • Analysis of UCA in healthy skin showed significant increase in total UCA content in non-photoexposed body sites compared with highly exposed skins.
  • In contrast, the percentage of cUCA was higher in photoexposed body sites.
  • No differences were found in total UCA concentration between the tumor samples and healthy photoexposed skin.
  • Higher levels of cUCA were detected in SCC biopsies (44% of total UCA) compared with samples of BCC and that of healthy photoexposed skin (30%).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Epidermis / radiation effects. Skin Neoplasms / pathology. Ultraviolet Rays. Urocanic Acid / metabolism

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  • (PMID = 18312386.001).
  • [ISSN] 1600-0625
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] G8D26XJJ3B / Urocanic Acid
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67. Salehi Z, Mashayekhi F, Shahosseini F: Significance of eIF4E expression in skin squamous cell carcinoma. Cell Biol Int; 2007 Nov;31(11):1400-4
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  • [Title] Significance of eIF4E expression in skin squamous cell carcinoma.
  • Cutaneous squamous cell carcinoma (SCC) is a malignant tumour of keratinising epidermal cells.
  • This type of skin cancer is the second leading cause of death after melanoma, and it is the second most common type of non-melanoma skin cancer after basal cell carcinoma.
  • The cellular and molecular events involved in the progression of skin cancers are largely unknown.
  • Translational control is critical for the proper regulation of the cell cycle, tissue induction and growth.
  • Eukaryotic initiation factor eIF4E, an important regulator of translation, plays critical roles in neo-plastic transformation and cancer progression.
  • We investigated eIF4E expression in 49 skin samples (six normal tissues, eight Bowen diseases, seven stage I, 10 stage II, 13 stage III and five stage IV SCCs).
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Eukaryotic Initiation Factor-4E / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Iran. Skin / metabolism


68. Gapska P, Scott RJ, Serrano-Fernandez P, Huzarski T, Byrski T, Kładny J, Gronwald J, Górski B, Cybulski C, Lubinski J, Debniak T: Vitamin D receptor variants and breast cancer risk in the Polish population. Breast Cancer Res Treat; 2009 Jun;115(3):629-33
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  • [Title] Vitamin D receptor variants and breast cancer risk in the Polish population.
  • The aim of the study was to determine whether four VDR gene single nucleotide polymorphisms (SNPs: rs1544410, rs731236, rs10735810 and rs4516035) are associated with breast cancer risk in Polish population.
  • Two independent series of female patients were employed: 960 consecutive breast cancer cases, and 800 unselected early onset cases diagnosed under the age of 51.
  • The control group for the consecutive breast cancer cases consisted of 960 healthy, age-matched women with a negative cancer family history.
  • 550 healthy women, aged 51 or less, with negative cancer family history were selected as the independent controls for the early onset breast cancer cases.
  • The frequencies of the VDR polymorphisms in the unselected cases when compared to the respective control population failed to reveal any association between the individual SNPs and disease.
  • Examination of the group of early-onset patients, revealed an association between rs10735810 and increased breast cancer risk.
  • The remaining three examined SNPs failed to show any association with disease risk.
  • In summary, this study has identified an association between the VDR gene and early onset breast cancer risk in the Polish population.
  • [MeSH-major] Breast Neoplasms / genetics. Polymorphism, Single Nucleotide / genetics. Receptors, Calcitriol / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Cohort Studies. Female. Humans. Middle Aged. Neoplasm Staging. Odds Ratio. Poland / epidemiology. Prognosis. Prospective Studies. Young Adult

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  • (PMID = 18587672.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Receptors, Calcitriol
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69. Aršavskaja J, Tekkel M, Lilleorg A, Padrik P, Metspalu A, Veidebaum T: BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia. Hered Cancer Clin Pract; 2010 Apr 09;8(1):4
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  • [Title] BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia.
  • We analyzed genetic data and questionnaire from 64 early-onset (< 45 y) breast cancer patients, 47 familial cases (patients with breast or ovarian cancer and a case of these cancers in the family), and 33 predictive cases (patients without breast or ovarian cancer, with a family history of such diseases) from Estonia for mutations in the BRCA1 gene.
  • A sub-set of familial cases and predictive cases were also analyzed for mutations in the BRCA2 gene.
  • RESULTS: We identified three clinically important mutations in the BRCA1 gene, including seven occurrences of the c.5382insC mutation, three of c.4154delA, and one instance of c.3881_3882delGA.
  • CONCLUSIONS: In our dataset, the overall frequency of clinically important BRCA1 mutations in early-onset patients, familial cases, and predictive testing was 7.6% (144 cases, 11 mutation carriers).
  • Pathogenic mutations were identified in 4 of the 64 early-onset breast cancer cases (6.3%).
  • In familial cases, clinically important mutations in the BRCA1 gene were found in 6 of the 47 individuals analyzed (12.8%).
  • In predictive cases, 1 clinically important mutation was detected in 33 individuals studied (3%).
  • The occurrence of clinically important mutations in BRCA2 in familial cases of breast cancer was 2 of the 16 individuals analyzed (12.5%).

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  • [ISSN] 1897-4287
  • [Journal-full-title] Hereditary cancer in clinical practice
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70. Cilliers D, Alanay Y, Boduroglu K, Utine E, Tunçbilek E, Clayton-Smith J: Cerebro-facio-thoracic dysplasia: expanding the phenotype. Clin Dysmorphol; 2007 Apr;16(2):121-5
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  • The second patient has hypodensity of the grey matter on magnetic resonance imaging, which is the second report of this finding in cerebro-facio-thoracic dysplasia.
  • In addition, he has hypoplasia of the corpus callosum.
  • These cases illustrate the expanding phenotype of this condition, and support the hypothesis that this is an autosomal recessive condition.


71. Boger-Megiddo I, Shaw DW, Friedman SD, Sparks BF, Artru AA, Giedd JN, Dawson G, Dager SR: Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord; 2006 Aug;36(6):733-9
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  • [Title] Corpus callosum morphometrics in young children with autism spectrum disorder.
  • This study assessed midsagittal corpus callosum cross sectional areas in 3-4 year olds with autism spectrum disorder (ASD) compared to typically developing (TD) and developmentally delayed (DD) children.
  • ASD clinical subgroup analysis revealed greater proportional callosum reduction in the more severely affected autistic disorder (AD) than in pervasive developmental disorder-not otherwise specified (PDD-NOS) children.
  • Subregion analysis revealed widely distributed callosum differences between ASD and TD children.
  • Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD.
  • [MeSH-major] Autistic Disorder / diagnosis. Corpus Callosum / pathology. Image Processing, Computer-Assisted. Magnetic Resonance Imaging
  • [MeSH-minor] Analysis of Variance. Biometry. Brain / pathology. Child, Preschool. Developmental Disabilities / diagnosis. Diagnosis, Differential. Female. Humans. Male. Mathematical Computing. Reference Values. Sex Factors


72. Saedon H, Hubbard A: An unusual presentation of merkel cell carcinoma of the eyelid. Orbit; 2008;27(4):331-3
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  • [Title] An unusual presentation of merkel cell carcinoma of the eyelid.
  • Merkel cell carcinoma is a rare primary neuroendocrine tumor occurring on any part of the body.
  • It usually presents as a firm, nontender, violaceous, or purple nodule located on areas of the body that have been exposed to sunlight.
  • Examination showed a 4 cm diameter, exophytic, ovoid skin lesion of the left lower lid.
  • Histological examination of therapeutic frozen section of the lesion and the presence of neuroendocrine marker and cytokeratin markers established the diagnosis of Merkel Cell carcinoma.
  • Merkel cell carcinoma can have an unusual presentation of a large, exophytic, oval lesion resembling a basal cell carcinoma.
  • Merkel cell carcinoma has predilection for rapid spread; hence, in a case of lid lesions, a suspicion for this diagnosis should be kept in mind.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Eyelid Neoplasms / chemistry. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Female. Humans

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  • (PMID = 18716977.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Buxton IL, Yokdang N, Matz RM: Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis. Cancer Lett; 2010 May 28;291(2):131-41
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  • [Title] Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis.
  • Several advances have recently expanded models of tumor growth and promoted the concept of tumor homeostasis, the hypothesis that primary tumors exert an anti-proliferative effect on both themselves and subclinical secondary metastases.
  • Recent trials indicate that the characterization of tumor growth as uncontrolled is inconsistent with animal models, clinical models, and epidemiological models.
  • There is a growing body of evidence which lends support to an updated concept of tumor growth: tumor homeostasis.
  • In the case of breast cancer, if not all metastasizing tumors, these advances suggest an inconvenient truth.
  • That is, if breast tumor cells metastasize to distant sites early in the tumorigenesis process, then removal of a breast tumor may hasten the development of its metastases.
  • We explore the heretofore unappreciated notion that nucleotides generated by tumor cells following the secretion of an ADP-kinase can promote metastasis and support angiogenesis.
  • Evidence is presented that blockade of the actions of nucleotides in the setting of newly diagnosed breast cancer may provide a useful adjunct to current anti-angiogenesis treatment.

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  • (PMID = 19926395.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD053028; United States / NCI NIH HHS / CA / T32 CA009563-20; United States / NICHD NIH HHS / HD / HD053028-03; United States / NCI NIH HHS / CA / NIH T32 CA09563; United States / NICHD NIH HHS / HD / HD053028; United States / NHLBI NIH HHS / HL / R01 HL056422-05; United States / NICHD NIH HHS / HD / R01 HD053028-03; United States / NCI NIH HHS / CA / T32 CA009563; United States / NHLBI NIH HHS / HL / R01 HL056422; United States / NCI NIH HHS / CA / CA009563-20; United States / NHLBI NIH HHS / HL / HL056422-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Receptors, Purinergic P2; 8L70Q75FXE / Adenosine Triphosphate
  • [Number-of-references] 170
  • [Other-IDs] NLM/ NIHMS152718; NLM/ PMC2849889
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74. Ito K, Miyahara T, Goto T, Horiuchi T, Sakai K, Hongo K: Solitary metastatic cauda equina tumor from breast cancer -case report-. Neurol Med Chir (Tokyo); 2010;50(5):417-20
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  • [Title] Solitary metastatic cauda equina tumor from breast cancer -case report-.
  • A 45-year-old woman presented with a rare case of metastatic cauda equina tumor from breast cancer without spinal column or brain metastasis.
  • She had undergone resection of breast cancer 4 years previously.
  • At surgery, the tumor was partially removed to preserve the nerve root function under electrophysiological monitoring.
  • The histological diagnosis was adenocarcinoma.
  • The tumor was located in the subarachnoid space, suggesting hematogenous metastasis from the breast cancer.
  • Cauda equina tumors may be relatively progressive regardless of imaging findings and clinical symptoms, so preoperative systemic investigation should be conducted, considering the possibility of metastatic tumor.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / pathology. Cauda Equina / pathology. Peripheral Nervous System Neoplasms / secondary

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  • (PMID = 20505303.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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75. Stinco G, Governatori G, Mattighello P, Patrone P: Multiple cutaneous neoplasms in a patient with Rothmund-Thomson syndrome: case report and published work review. J Dermatol; 2008 Mar;35(3):154-61
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  • [Title] Multiple cutaneous neoplasms in a patient with Rothmund-Thomson syndrome: case report and published work review.
  • Rothmund-Thomson syndrome (RTS) is a rare genodermatosis characterized by early poikilodermatous skin lesions, often combined with juvenile cataracts, photosensitivity and bone defects.
  • Data in the published work indicate that there is an increased risk of RTS patients developing malignant tumors.
  • Herein, we report the multiple skin carcinomas observed in a case of RTS and review the published work on the occurrence of malignant tumors in these patients.
  • We report the case of a 63-year-old male with RTS who developed multiple cutaneous neoplasms (three basal cell carcinomas, three squamous cell carcinomas and Bowen's disease) over the previous 15 years.
  • A published work review confirmed that RTS is a genetic condition that predisposes subjects to the development of bone tumors, especially at an early age, and skin tumors at an adult age.
  • Therefore, alongside careful osteoarticular monitoring to identify a bone tumor quickly, during the life of a patient suffering from the syndrome, it is just as important to take appropriate preventive action and monitor the possible onset of skin tumors.
  • [MeSH-major] Carcinoma / etiology. Rothmund-Thomson Syndrome / complications. Skin Neoplasms / etiology

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  • (PMID = 18346259.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 67
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76. Formicone F, Fargnoli MC, Pisani F, Rascente M, Famulari A, Peris K: Cutaneous manifestations in Italian kidney transplant recipients. Transplant Proc; 2005 Jul-Aug;37(6):2527-8
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  • Twenty (22%) nonmelanoma skin cancers were identified in seven (6.4%) patients, six basal cell carcinomas (BCC) in four patients, two squamous cell carcinomas (SCC) in two patients, and 11 BCCs in addition to one SCC in one patient.
  • Our results emphasize the importance of dermatologic examinations and monitoring kidney transplant recipients to obtain an early diagnosis and treatment of cutaneous manifestations.
  • [MeSH-major] Kidney Transplantation / adverse effects. Skin Diseases / etiology
  • [MeSH-minor] Adult. Aged. Female. Humans. Incidence. Italy. Male. Middle Aged. Mycoses / epidemiology. Postoperative Complications / classification. Postoperative Complications / epidemiology. Retrospective Studies. Skin Neoplasms / epidemiology. Virus Diseases / epidemiology


77. Pakseresht S, Ingle GK, Bahadur AK, Ramteke VK, Singh MM, Garg S, Agarwal PN: Risk factors with breast cancer among women in Delhi. Indian J Cancer; 2009 Apr-Jun;46(2):132-8
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  • [Title] Risk factors with breast cancer among women in Delhi.
  • BACKGROUND: The incidence of breast cancer is on the rise in India, breast cancer is the second most common malignancy in Indian women.
  • AIM: The aim of this study was to find out the association of various risk factors with breast cancer among women in Delhi.
  • SETTINGS AND DESIGN: This was a case-control study in Lok Nayak Hospital, Delhi.
  • Subjects were women with breast cancer (N = 115) and age matched Control subjects (N-217) without breast cancer, attending Lok Nayak Hospital during 2006.
  • The risk factors studied were: age, parity, socioeconomic status, marital status, breast feeding, menarche, menopause, family history.
  • In this study, 69 (60%) cases and 127 (58.5%) controls were illiterate, the mean duration sum of total breast feeding for all children was 6.58 years in cases and 7.4 years in controls (OR = 1.91; 95% CI, 1.17 - 3.13) (P P P< 0.05).
  • There was a significant difference between breast cancer cases and controls in relation to place of residence, occupation, marital status, body mass index and breast feeding.
  • [MeSH-major] Breast Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Body Mass Index. Breast Feeding. Case-Control Studies. Confidence Intervals. Female. Humans. India / epidemiology. Marital Status. Middle Aged. Odds Ratio. Risk Factors. Surveys and Questionnaires

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  • (PMID = 19346647.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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78. Ha M, Mabuchi K, Sigurdson AJ, Freedman DM, Linet MS, Doody MM, Hauptmann M: Smoking cigarettes before first childbirth and risk of breast cancer. Am J Epidemiol; 2007 Jul 1;166(1):55-61
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  • [Title] Smoking cigarettes before first childbirth and risk of breast cancer.
  • Inconsistent epidemiologic findings on cigarette smoking and female breast cancer risk may reflect insufficient assessment of smoking onset and amount relative to reproductive events.
  • To determine the risk of breast cancer associated with smoking during different periods of reproductive life, the authors evaluated 906 incident breast cancer cases in a nationwide cohort of 56,042 female US radiologic technologists (1983-1998) who responded to two questionnaire surveys.
  • After they accounted for age, birth cohort, and established breast cancer risk factors, smoking-related breast cancer risks differed by smoking during three reproductive time periods (p = 0.003), with a statistically significant 3% increase per pack-year of smoking between menarche and first childbirth (relative risk = 1.03, 95% confidence interval: 1.02, 1.05) and no significant association for smoking after first childbirth.
  • The findings from this study suggest that sensitivity of the female breast to tobacco carcinogens is increased during adolescence and early adulthood but decreases after first childbirth, when most breast tissue has terminally differentiated.
  • [MeSH-major] Breast Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 17426039.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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79. Ramachandran S, Rajaratnam R, Smith AG, Lear JT, Strange RC: Patients with both basal and squamous cell carcinomas are at a lower risk of further basal cell carcinomas than patients with only a basal cell carcinoma. J Am Acad Dermatol; 2009 Aug;61(2):247-51
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  • [Title] Patients with both basal and squamous cell carcinomas are at a lower risk of further basal cell carcinomas than patients with only a basal cell carcinoma.
  • BACKGROUND: The rate of development of further basal cell carcinoma (BCC) after first presentation is highly variable.
  • OBJECTIVE: We assessed the risks of developing a subsequent BCC in patients who developed a BCC and a squamous cell carcinoma (SCC) and compared them with patients who developed a BCC only.
  • METHODS: In all, 1040 patients who developed BCC only were compared with 140 patients who developed BCC and SCC to see whether the latter group included a high proportion of risk phenotypes (eg, male sex and fair skin).
  • We then compared the number of BCCs developing per year in the two groups (174 BCC only and 71 BCC/SCC) during a 5-year period after initial BCC presentation.
  • RESULTS: The BCC/SCC group demonstrated a significantly lower BCC/year rate than BCC only group.
  • The rate of development of further BCC during 5-year follow-up was lower in the BCC/SCC group because a smaller number of patients developed subsequent BCC and not because the same proportion of patients developed lesions but in smaller numbers.
  • After 5 years of follow-up, 51.1% of BCC and 74.6% of BCC/SCC cases were free from a subsequent BCC.
  • Logistic regression analysis corrected for age at initial presentation confirmed that patients with BCC/SCC were less likely to develop a further BCC during the 5 years after initial presentation (P = .001, odds ratio = 0.31, 95% confidence interval 0.15-0.63).
  • LIMITATIONS: Because of the large patient group and long study follow-up from the date of the index BCC or SCC, not all data were obtained.
  • Where this is the case, the number of patients for whom the information is available is provided.
  • CONCLUSIONS: Patients who develop a BCC are similar to patients who develop both a BCC and SCC, confirming the overlap of causative factors.
  • Patients who develop both a BCC and SCC are less likely to develop BCCs compared with patients who develop BCC only.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Multiple Primary / epidemiology
  • [MeSH-minor] Age Distribution. Aged. Aged, 80 and over. Cohort Studies. Confidence Intervals. Female. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Neoplasm Staging. Odds Ratio. Probability. Prognosis. Risk Assessment. Sex Distribution

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  • (PMID = 19481292.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Friedrich RE: Diagnosis and treatment of patients with nevoid basal cell carcinoma syndrome [Gorlin-Goltz syndrome (GGS)]. Anticancer Res; 2007 Jul-Aug;27(4A):1783-7
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  • [Title] Diagnosis and treatment of patients with nevoid basal cell carcinoma syndrome [Gorlin-Goltz syndrome (GGS)].
  • BACKGROUND: The nevoid basal cell carcinoma syndrome (NBCC) is a rare and autosomal dominant inherited disease with well-defined characteristics, summarized by Gorlin and Goltz in 1960.
  • In the head and neck region, cerebral calcifications, basal cell carcinoma (BCC) and multiple keratocysts of the jaws are the predominant findings.
  • Thirteen patients were also physically investigated, including X-ray diagnosis.
  • The number of patients with characteristic head and neck findings in the spectrum of NBCC varied: basal cell carcinoma (n = 15), keratocysts of the jaws (n = 13), cerebral calcification visible on plain radiographs (n = 15), palmar pits (n = 9).
  • One of these 2 patients underwent external irradiation for a BCC of the frontotemporal region.
  • Nine years later a frontal BCC had to be treated.
  • The other developed several other BCC inside and outside the irradiation field.
  • Up to 50 BCC per patient had to be resected.
  • Interdisciplinary cooperation is mandatory in the diagnosis and follow-up control of patients with NBCC.
  • [MeSH-major] Basal Cell Nevus Syndrome / diagnosis. Basal Cell Nevus Syndrome / surgery

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  • (PMID = 17649773.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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81. Kalantar DH, Belak JF, Collins GW, Colvin JD, Davies HM, Eggert JH, Germann TC, Hawreliak J, Holian BL, Kadau K, Lomdahl PS, Lorenzana HE, Meyers MA, Rosolankova K, Schneider MS, Sheppard J, Stölken JS, Wark JS: Direct observation of the alpha-epsilon transition in shock-compressed iron via nanosecond x-ray diffraction. Phys Rev Lett; 2005 Aug 12;95(7):075502
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  • In situ x-ray diffraction studies of iron under shock conditions confirm unambiguously a phase change from the bcc (alpha) to hcp (epsilon) structure.

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  • (PMID = 16196791.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. El-Marakby HH: The versatile naso-labial flaps in facial reconstruction. J Egypt Natl Canc Inst; 2005 Dec;17(4):245-50
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  • Skin grafts can only cover superficial defects and has a natural tendency to contract and may not take properly.
  • MATERIAL AND METHODS: The study included 20 patients (12 males and 8 females) presented at the surgical department, National Cancer Institute (NCI) Cairo University with skin cancer at different areas of the face.
  • Assessment of the stage of the disease, the flap design and patient general condition.
  • Fifteen patients presented with basal cell carcinoma, 2 squamous cell carcinoma, one malignant melanoma, one keratoacanthoma, and one xeroderma pigmentosa.
  • Nasal defects constituted 75% of cases, the rest were lower eye lid (2), one upper lip and one oral commisure beside a case of cheek reconstruction.
  • There was no major complication; only one patient suffered a reactionary hemorrhage that required re-exploration to secure the bleeder.
  • The overall aesthetic results were very satisfactory in the majority of patients (16), and satisfactory in 2 cases.
  • [MeSH-major] Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 17102819.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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83. Mamelak AJ, Wang SQ, Goldberg LH: Linear closure for nasal defects after Mohs micrographic surgery. J Drugs Dermatol; 2009 Jan;8(1):23-8
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  • BACKGROUND: Skin cancers on the nose are very common.
  • METHODS: A retrospective analysis was conducted of 4765 patients with skin malignancies on the nose that were treated with MMS between July 1997 and January 2006.
  • The 2 major malignancies treated were basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Nose Neoplasms / surgery. Prospective Studies. Retrospective Studies. Skin Transplantation. Surgical Flaps. Young Adult

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  • (PMID = 19180892.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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84. Tao H, Kitagawa N, Kako Y, Yamanaka H, Ito K, Denda K, Koyama T: A case of anorexia nervosa with Marchiafava-Bignami Disease that responded to high-dose intravenous corticosteroid administration. Psychiatry Res; 2007 Nov 15;156(2):181-4
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  • [Title] A case of anorexia nervosa with Marchiafava-Bignami Disease that responded to high-dose intravenous corticosteroid administration.
  • We report the first known case of anorexia nervosa (AN) with Marchiafava-Bignami Disease (MBD) that responded to high-dose intravenous corticosteroid administration.
  • On admission, magnetic resonance imaging showed an area of demyelination in the splenium of the corpus callosum.
  • [MeSH-major] Anorexia Nervosa / complications. Fursultiamin / administration & dosage. Marchiafava-Bignami Disease / drug therapy. Methylprednisolone / administration & dosage. Neuroprotective Agents / administration & dosage. Vitamin B Complex / administration & dosage
  • [MeSH-minor] Adolescent. Corpus Callosum / blood supply. Corpus Callosum / drug effects. Corpus Callosum / pathology. Dose-Response Relationship, Drug. Female. Frontal Lobe / blood supply. Frontal Lobe / drug effects. Frontal Lobe / pathology. Glasgow Coma Scale. Humans. Infusions, Intravenous. Magnetic Resonance Imaging. Neurologic Examination / drug effects. Positron-Emission Tomography. Regional Blood Flow / drug effects. Temporal Lobe / blood supply. Temporal Lobe / drug effects. Temporal Lobe / pathology

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  • (PMID = 17933499.001).
  • [ISSN] 0165-1781
  • [Journal-full-title] Psychiatry research
  • [ISO-abbreviation] Psychiatry Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 05J61265PX / Fursultiamin; 12001-76-2 / Vitamin B Complex; X4W7ZR7023 / Methylprednisolone
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85. Wang SQ, Dusza SW, Scope A, Braun RP, Kopf AW, Marghoob AA: Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study. Dermatol Surg; 2008 Oct;34(10):1389-95
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  • OBJECTIVE: The objective was to evaluate whether diagnosis and diagnostic confidence changes when viewing dermoscopic images from NPDs and PDs.
  • Twenty-five pigmented lesions were shown in the study, consisting of 7 seborrheic keratoses (SK), 3 basal cell carcinomas, 2 atypical nevi, 5 malignant melanomas (MM), 3 dermatofibromas, 3 blue nevi, and 2 hemangiomas.
  • CONCLUSIONS: Viewing lesions with NPD versus PD can affect the diagnosis and diagnostic confidence of physicians that are novices with dermoscopy.
  • [MeSH-major] Dermoscopy / instrumentation. Skin Diseases / diagnosis
  • [MeSH-minor] Humans. Microscopy, Polarization. Pigmentation Disorders / diagnosis. Pilot Projects. Skin Neoplasms / diagnosis


86. Saalbach A, Lange O, Nattkemper T, Meyer-Baese A: On the application of (topographic) independent and tree-dependent component analysis for the examination of DCE-MRI data. Biomed Signal Process Control; 2009 Jul;4(3):247-253
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  • In this contribution we investigate the applicability of different methods from the field of independent component analysis (ICA) for the examination of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data from breast cancer research.
  • DCE-MRI has evolved in recent years as a powerful complement to X-ray based mammography for breast cancer diagnosis and monitoring.
  • In DCE-MRI the time related development of the signal intensity after the administration of a contrast agent can provide valuable information about tissue states and characteristics.
  • In order to evaluate the applicability of ICA, topographic ICA and tree-dependent component analysis (TCA), these methods are applied to twelve clinical cases from breast cancer research with a histopathologically confirmed diagnosis.

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  • (PMID = 20689662.001).
  • [ISSN] 1746-8094
  • [Journal-full-title] Biomedical signal processing and control
  • [ISO-abbreviation] Biomed Signal Process Control
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA106799-04; United States / NCI NIH HHS / CA / K25 CA106799
  • [Publication-type] JOURNAL ARTICLE
  • [Publication-country] England
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87. Fujino H, Saito T, Ogawa S, Kojima J: Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol; 2005 Oct;57(10):1305-11
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  • A significant stimulatory effect was exhibited by pitavastatin lactone, while the acid form did not exhibit ATPase hydrolysis of P-glycoprotein.
  • In the case of breast cancer resistant protein (BCRP), the acid form of pitavastatin is a substrate, whereas the lactone form is not.
  • Taking these results into consideration, several SLC and ABC transporters were identified as critical to the distribution and excretion of pitavastatin in the body.
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette Transporters / metabolism. Adenosine Triphosphatases / metabolism. Animals. Carbon Radioisotopes. Dose-Response Relationship, Drug. Female. Humans. Kinetics. Neoplasm Proteins / metabolism. Oocytes / drug effects. Oocytes / metabolism. Organic Anion Transporters, Sodium-Dependent / genetics. Organic Anion Transporters, Sodium-Dependent / metabolism. Organic Anion Transporters, Sodium-Independent / genetics. Organic Anion Transporters, Sodium-Independent / metabolism. Rats. Solute Carrier Organic Anion Transporter Family Member 1B3. Solute Carrier Organic Anion Transporter Family Member 1b1 / genetics. Solute Carrier Organic Anion Transporter Family Member 1b1 / metabolism. Symporters / genetics. Symporters / metabolism. Xenopus laevis

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  • (PMID = 16259759.001).
  • [ISSN] 0022-3573
  • [Journal-full-title] The Journal of pharmacy and pharmacology
  • [ISO-abbreviation] J. Pharm. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / Carbon Radioisotopes; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Neoplasm Proteins; 0 / Organic Anion Transporters; 0 / Organic Anion Transporters, Sodium-Dependent; 0 / Organic Anion Transporters, Sodium-Independent; 0 / Quinolines; 0 / SLCO1B3 protein, human; 0 / Solute Carrier Organic Anion Transporter Family Member 1B3; 0 / Solute Carrier Organic Anion Transporter Family Member 1b1; 0 / Symporters; 145420-23-1 / sodium-bile acid cotransporter; EC 3.6.1.- / Adenosine Triphosphatases; M5681Q5F9P / pitavastatin
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88. Kenzaka T, Ishidoshiro A, Yamaguchi N, Tani K, Nasu M: rRNA sequence-based scanning electron microscopic detection of bacteria. Appl Environ Microbiol; 2005 Sep;71(9):5523-31
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  • SEM-ISH was applied to analyze bacterial community composition in freshwater samples, and bacterial cell counts determined by SEM-ISH with rRNA-targeted probes for major phyla within the domain Bacteria were highly correlated to those by fluorescent in situ hybridization (FISH).
  • The bacterial composition on surface of river sediment particles before and after cell dispersion treatment by sonication was successfully revealed by SEM-ISH.

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  • (PMID = 16151145.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oligonucleotide Probes; 0 / RNA, Ribosomal; 7440-57-5 / Gold
  • [Other-IDs] NLM/ PMC1214627
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89. Francisco G, Neto CF, Sanches JA Jr, Ruiz IR: Genomic instability in basal cell carcinomas. J Dermatol Sci; 2005 Sep;39(3):186-8
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  • [Title] Genomic instability in basal cell carcinomas.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Genomic Instability / genetics. Skin Neoplasms / genetics

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  • (PMID = 16085392.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers
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90. Kassem A, Pantulu D, Technau K, Kurz AK, Diaz C, Hörster S, Nashan D, Weyers W, Zur Hausen A: Merkel cell polyomavirus in naevoid basal cell carcinoma syndrome-associated basal cell carcinomas and sporadic trichoblastomas. J Dermatol Sci; 2010 Aug;59(2):140-2
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  • [Title] Merkel cell polyomavirus in naevoid basal cell carcinoma syndrome-associated basal cell carcinomas and sporadic trichoblastomas.
  • [MeSH-major] Basal Cell Nevus Syndrome / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Merkel Cell / genetics. DNA, Neoplasm / genetics. DNA, Viral / genetics. Polyomavirus / genetics. Skin Neoplasms / genetics

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  • (PMID = 20654786.001).
  • [ISSN] 1873-569X
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / DNA, Viral
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91. Mitsuhashi M, Peel D, Ziogas A, Anton-Culver H: Enhanced Expression of Radiation-induced Leukocyte CDKN1A mRNA in Multiple Primary Breast Cancer Patients: Potential New Marker of Cancer Susceptibility. Biomark Insights; 2009 Dec 22;4:201-9
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  • [Title] Enhanced Expression of Radiation-induced Leukocyte CDKN1A mRNA in Multiple Primary Breast Cancer Patients: Potential New Marker of Cancer Susceptibility.
  • This study was designed to discover blood biomarkers of cancer susceptibility using invasive multiple (n = 21), single primary breast cancer (n = 21), and control subjects (n = 20).
  • Heparinized whole blood was incubated at 37 degrees C for 2 hours after 0-10 Gy of radiation, then cell cycle arrest marker CDKN1A and apoptosis marker BBC3 mRNA were quantified.
  • Interestingly, multiple primary cases showed higher induction of CDKN1A mRNA than single primary and control groups, whereas BBC3 did not show such differences.
  • The results suggested that cancer susceptibility represented by the multiple primary breast cancer cases was related to over-reaction of CDKN1A mRNA, not BBC3.
  • The study also suggests that ex vivo gene expression analysis could potentially be used as a new tool in epidemiological studies for cancer and radiation sensitivity research.

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  • (PMID = 20072670.001).
  • [ISSN] 1177-2719
  • [Journal-full-title] Biomarker insights
  • [ISO-abbreviation] Biomark Insights
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA058860; United States / NCI NIH HHS / CA / U01 CA058860
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2805425
  • [Keywords] NOTNLM ; BBC3 / CDKN1A / DNA damage / cancer susceptibility Mitsuhashi et al / multiple primary cancer
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92. Wang X, Chao L, Chen L, Ma G, Jin G, Hua M, Zhou G: The mammographic correlations with Basal-like phenotype of invasive breast cancer. Acad Radiol; 2010 Mar;17(3):333-9
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  • [Title] The mammographic correlations with Basal-like phenotype of invasive breast cancer.
  • RATIONALE AND OBJECTIVES: Mammography contributes to the improvement of breast carcinoma survival through early detection and treatment of breast lesions.
  • The basal-like phenotype has been found to be an independent poor prognostic factor for breast cancer.
  • The aim of this study was to determine the mammographic correlates of the basal-like phenotype of invasive breast cancer, and to more precisely predict patient outcome and those individuals who will be responsive to a specific therapeutic regimen.
  • MATERIALS AND METHODS: The mammographic findings in 267 patients with operable breast cancer were correlated with the basal-like subtype identified using immunohistochemical assessment of breast cancer cases, including estrogen receptor, progesterone receptor, HER-2/neu status, cytokeratin (CK5/6), and epidermal growth factor receptor.
  • RESULTS: Of the 267 invasive breast cancers, 40 (15%) were of the basal-like phenotype.
  • Basal-phenotype tumors were significantly more likely to manifest as a mass (P = .002), most of which were indistinct margin (P =.035), at mammography, and architecture distortion at mammography (P = .002).
  • CONCLUSION: The mammographic appearances of basal-like tumors, more mass and architecture distortion, suggest more rapid carcinogenesis.
  • Additional studies are warranted to further refine prognosis, and to optimize treatment in patients with basal-like breast cancer.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / radiography. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / radiography. Mammography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Reproducibility of Results. Sensitivity and Specificity. Statistics as Topic


93. Haas S, Park TW, Hahne JC, Fischer HP: Influence of preoperative core biopsies on uPA/PAI-1 expression in breast cancer tissue. Virchows Arch; 2008 Mar;452(3):277-83
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  • [Title] Influence of preoperative core biopsies on uPA/PAI-1 expression in breast cancer tissue.
  • The urokinase-type plasminogen activator (uPA) and the plasminogen activator inhibitor-1 (PAI-1) are involved in tumor invasion and metastasis as well as wound healing and inflammation.
  • We investigated the impact of tissue injury by preoperative sampling on the level of uPA/PAI-1 in paraffin tissue of 55 breast cancer cases by immunohistochemistry.
  • The tumor area surrounding the biopsy channel was compared with distant intact tumor tissue. uPA and PAI-1 were constantly expressed by the tumor cells.
  • Fibroblastic expression was higher in the tumor area surrounding the biopsy channel than in intact tissue with 47 vs 29 positive cases for uPA (p<0.001) and 35 vs 25 positive cases for PAI-1 (p=0.055).
  • A decrease in fibroblastic enzyme expression from the biopsy area to the intact tumor tissue was seen in 21 cases for uPA and 16 cases for PAI-1.
  • This difference was most evident in cases with an interval of 6 days and longer between biopsy and surgery.
  • Tissue specimen for ELISA analysis should not be taken from the tumor area around the biopsy channel in the resection specimen.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Plasminogen Activator Inhibitor 1 / biosynthesis. Urokinase-Type Plasminogen Activator / biosynthesis

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  • (PMID = 18196271.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Plasminogen Activator Inhibitor 1; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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94. Crump RC, Adams HE, Hobbie JE, Kling GW: Biogeography of bacterioplankton in lakes and streams of an Arctic tundra catchment. Ecology; 2007 Jun;88(6):1365-78
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  • [Title] Biogeography of bacterioplankton in lakes and streams of an Arctic tundra catchment.
  • Bacterioplankton community composition was compared across 10 lakes and 14 streams within the catchment of Toolik Lake, a tundra lake in Arctic Alaska, during seven surveys conducted over three years using denaturing gradient gel electrophoresis (DGGE) of PCR-amplified rDNA.
  • Bacterioplankton communities in streams draining tundra were very different than those in streams draining lakes.
  • Communities in streams draining lakes were similar to communities in lakes.
  • In a connected series of lakes and streams, the stream communities changed with distance from the upstream lake and with changes in water chemistry, suggesting inoculation and dilution with bacteria from soil waters or hyporheic zones.
  • In the same system, lakes shared similar bacterioplankton communities (78% similar) that shifted gradually down the catchment.
  • In contrast, unconnected lakes contained somewhat different communities (67% similar).
  • We found evidence that dispersal influences bacterioplankton communities via advection and dilution (mass effects) in streams, and via inoculation and subsequent growth in lakes.
  • The spatial pattern of bacterioplankton community composition was strongly influenced by interactions among soil water, stream, and lake environments.
  • Our results reveal large differences in lake-specific and stream-specific bacterial community composition over restricted spatial scales (<10 km) and suggest that geographic distance and connectivity influence the distribution of bacterioplankton communities across a landscape.
  • [MeSH-major] Bacteria / growth & development. Biodiversity. Fresh Water / microbiology. Plankton / growth & development. Water Microbiology
  • [MeSH-minor] Arctic Regions. DNA, Bacterial / analysis. DNA, Ribosomal Spacer. Ecosystem. Electrophoresis, Polyacrylamide Gel. Polymerase Chain Reaction. Population Dynamics. Rivers / microbiology. Water Movements

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  • (PMID = 17601129.001).
  • [ISSN] 0012-9658
  • [Journal-full-title] Ecology
  • [ISO-abbreviation] Ecology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal Spacer
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95. Yamamoto F, Yamamoto M: Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods. Electrophoresis; 2007 Jun;28(12):1882-95
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  • We examined differences in copy number and expression of 127 genes located on the 18q21-qter chromosomal region of the breast and prostate cancer cell lines, using the systematic multiplex PCR and reverse transcription-PCR (SM PCR and SM RT-PCR) methods that we developed.
  • In the chromosomal region where losses are frequent in breast, prostate, and other cancers, we detected a homozygous deletion of the SMAD4 gene in the MDA-MB-468 breast cancer cell line.
  • We also observed partial or entire loss of expression in genes such as CCBE1, CCDC11, CD226, NP_115536.1, NP_689683.2, RNF152, SERPINB8, and TCF4 in certain breast and/or prostate cancer cell lines.
  • An increase in gene expression was rare, but found with the transcription factor ONECUT2 gene in all of the cancer cell lines examined.
  • Further analysis of clinical specimens of breast cancer by real-time qRT-PCR demonstrated that the gene expression of CCBE1, TCF4, NP_115536.1, and NP_689683.2 was downregulated in the majority of clinical cases of breast cancer.
  • [MeSH-major] Breast Neoplasms / genetics. Carcinoma, Ductal / genetics. Chromosomes, Human, Pair 18 / genetics. Gene Dosage. Gene Expression. Prostatic Neoplasms / genetics
  • [MeSH-minor] Cell Line. DNA Primers. Female. Gene Amplification / genetics. Gene Deletion. Gene Expression Profiling. Humans. Male. Oligonucleotide Array Sequence Analysis / methods. Polymerase Chain Reaction / methods. Reverse Transcriptase Polymerase Chain Reaction / methods. Transcription, Genetic. Tumor Cells, Cultured

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  • (PMID = 17523142.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01CA087069
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers
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96. Anderson WF, Matsuno RK, Sherman ME, Lissowska J, Gail MH, Brinton LA, Yang XR, Peplonska B, Chen BE, Rosenberg PS, Chatterjee N, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Devesa SS, García-Closas M: Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions. Cancer Causes Control; 2007 May;18(4):439-47
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  • [Title] Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions.
  • OBJECTIVE: Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues.
  • METHOD: Using a population-based case-control study in Poland (2000-2003) of 2,386 incident breast cancer cases and 2,502 control subjects aged 25-74 years, we estimated age-specific breast cancer incidence rates according to risk factors.
  • RESULTS: Breast cancer risks were elevated among women with positive family history (FH), younger age at menarche, older age at first full-term birth, nulliparity, exogenous hormonal usage, and reduced physical activity (PA).
  • For example, nulliparity compared to parity reduced breast cancer risk among women ages 25-39 years then rates crossed or reversed, after which nulliparity increased relative risks among women ages 40-74 years.
  • If confirmed in other populations, qualitative interactions for a continuous covariate such as age will be difficult to reconcile in a sequential (multistep or monolithic) 'stochastic' breast cancer model.
  • Alternatively, the reversal of relative risks among younger and older women suggests subgroup heterogeneity with different etiologic mechanisms for early-onset and late-onset breast cancer types.
  • [MeSH-major] Breast Neoplasms / epidemiology. Risk Assessment / methods
  • [MeSH-minor] Adult. Age Factors. Aged. Body Mass Index. Case-Control Studies. Female. Hormone Replacement Therapy / utilization. Humans. Incidence. Middle Aged. Motor Activity. Poland / epidemiology. Risk. Risk Factors

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  • (PMID = 17216325.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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97. Mao X, Hamoudi RA, Zhao P, Baudis M: Genetic losses in breast cancer: toward an integrated molecular cytogenetic map. Cancer Genet Cytogenet; 2005 Jul 15;160(2):141-51
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  • [Title] Genetic losses in breast cancer: toward an integrated molecular cytogenetic map.
  • Breast cancer is the most common malignant disease in Caucasian women, but is less frequent in Chinese women.
  • The molecular basis for such ethnical difference in disease pathogenesis remains unknown.
  • To address this issue, we performed allelotyping analysis of formalin-fixed, paraffin-embedded samples from 21 Chinese patients with breast cancer using 59 fluorescently tagged oligonucleotide primers amplifying microsatellite loci.
  • Loss of heterozygosity (LOH) was found in all tumor samples.
  • To compare our data to previous reports, we determined the band-specific frequency of chromosomal imbalances in breast cancer karyotypes reported in the Mitelman database, and from the CGH results of cases accessible through the Progenetix website.
  • Furthermore, published LOH analyses of breast cancer cases were compared to our own LOH results, demonstrating the most common chromosomal regions affected by allelic losses.
  • The combined results provide a comprehensive view of genetic losses in breast cancers, indicating the comparability of these different techniques and suggesting the presence of a distinct subset of breast cancers with high-frequency LOH at chromosomes 1 and 2p in Chinese patients.
  • [MeSH-major] Breast Neoplasms / genetics. Cytogenetic Analysis. Loss of Heterozygosity / genetics

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  • (PMID = 15993270.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Jovanov-Milosević N, Culjat M, Kostović I: Growth of the human corpus callosum: modular and laminar morphogenetic zones. Front Neuroanat; 2009;3:6
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  • [Title] Growth of the human corpus callosum: modular and laminar morphogenetic zones.
  • The purpose of this focused review is to present and discuss recent data on the changing organization of cerebral midline structures that support the growth and development of the largest commissure in humans, the corpus callosum.
  • We will put an emphasis on the callosal growth during the period between 20 and 45 postconceptual weeks (PCW) and focus on the advantages of a correlated histological/magnetic resonance imaging (MRI) approach.
  • The midline structures that mediate development of the corpus callosum in rodents, also mediate its early growth in humans.
  • Postmortem MRI at 3 T can demonstrate transient structures based on higher water content in ECM, and give us the possibility to follow the growth of the corpus callosum in vivo, due to the characteristic MR signal.

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  • (PMID = 19562029.001).
  • [ISSN] 1662-5129
  • [Journal-full-title] Frontiers in neuroanatomy
  • [ISO-abbreviation] Front Neuroanat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC2697006
  • [Keywords] NOTNLM ; callosal septa / fetal brain / glia of indusium griseum / magnetic resonance imaging / midline structures / semaphorin3A
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99. Milleret C, Buser P, Watroba L: Unilateral paralytic strabismus in the adult cat induces plastic changes in interocular disparity along the visual midline: contribution of the corpus callosum. Vis Neurosci; 2005 May-Jun;22(3):325-43
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  • [Title] Unilateral paralytic strabismus in the adult cat induces plastic changes in interocular disparity along the visual midline: contribution of the corpus callosum.
  • Neurones activated through the corpus callosum (CC) in the cat visual cortex are known to be almost entirely located at the 17/18 border.
  • On the other hand, strabismus induced a loss of orientation selectivity regardless of whether neurones were activated directly or through the CC.
  • [MeSH-major] Corpus Callosum / physiopathology. Functional Laterality / physiology. Neuronal Plasticity / physiology. Strabismus / physiopathology. Vision Disparity / physiology. Visual Fields / physiology

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  • (PMID = 16079008.001).
  • [ISSN] 0952-5238
  • [Journal-full-title] Visual neuroscience
  • [ISO-abbreviation] Vis. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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100. Pfefferbaum A, Adalsteinsson E, Sullivan EV: Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism. Neurobiol Aging; 2006 Jul;27(7):994-1009
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  • [Title] Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism.
  • To quantify the potential compounded effect of age and alcoholism, we used conventional structural MRI and diffusion tensor imaging (DTI) to examine the macrostructural and microstructural integrity of the corpus callosum, one of the most prominent white matter structures of the brain, in 131 adults, age 27-75 years.
  • Compared with the 74 controls, the 40 alcoholic men and 17 alcoholic women, who were abstinent from alcohol for an average of 3 months, showed similar patterns and extents of callosal shrinkage, which was greatest in the genu and body and less prominent in the splenium.
  • [MeSH-major] Aging / pathology. Alcohol-Induced Disorders, Nervous System / pathology. Alcoholism / pathology. Corpus Callosum / drug effects. Corpus Callosum / pathology. Ethanol / adverse effects
  • [MeSH-minor] Adult. Age Factors. Aged. Anisotropy. Body Water / drug effects. Body Water / physiology. Brain Mapping. Diffusion / drug effects. Diffusion Magnetic Resonance Imaging. Female. Gait Disorders, Neurologic / chemically induced. Gait Disorders, Neurologic / pathology. Gait Disorders, Neurologic / physiopathology. Humans. Male. Memory Disorders / chemically induced. Memory Disorders / pathology. Memory Disorders / physiopathology. Middle Aged. Myelin Sheath / drug effects. Myelin Sheath / pathology. Nerve Fibers, Myelinated / drug effects. Nerve Fibers, Myelinated / pathology. Predictive Value of Tests. Wallerian Degeneration / chemically induced. Wallerian Degeneration / pathology. Wallerian Degeneration / physiopathology

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  • (PMID = 15964101.001).
  • [ISSN] 0197-4580
  • [Journal-full-title] Neurobiology of aging
  • [ISO-abbreviation] Neurobiol. Aging
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG17919; United States / NIAAA NIH HHS / AA / R01 AA012388; United States / NIAAA NIH HHS / AA / AA05965; United States / NIAAA NIH HHS / AA / AA 10723; United States / NIAAA NIH HHS / AA / AA 12388
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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