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1. Kluger N, Guillot B: Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report. Cases J; 2009;2:8868
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy.
  • CASE PRESENTATION: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate.
  • After prostatectomy, pigmented lesions stopped their brutal increase but did not regress.

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  • [Cites] J Am Acad Dermatol. 1996 Jul;35(1):88-95 [8682971.001]
  • [Cites] Arch Dermatol. 1975 Jun;111(6):792-3 [1169918.001]
  • (PMID = 19918348.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769478
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2. Bölke E, Gerber PA, Peiper M, Knoefel WT, Cohnen M, Matuschek C, Budach W, Engers R, Gripp S: Leser-Trélat sign presenting in a patient with ovarian cancer: a case report. J Med Case Rep; 2009;3:8583
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  • INTRODUCTION: Seborrheic keratoses are very common findings in elderly patients.
  • CASE PRESENTATION: A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years.
  • Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign.
  • CONCLUSION: The Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years.
  • Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations.

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  • [Cites] N Engl J Med. 2007 May 24;356(21):2184 [17522402.001]
  • [Cites] Gynecol Oncol. 2006 May;101(2):353-5 [16443260.001]
  • [Cites] J Clin Oncol. 1997 Mar;15(3):1272-82 [9060572.001]
  • [Cites] J Am Acad Dermatol. 1996 Jul;35(1):88-95 [8682971.001]
  • [Cites] J Am Acad Dermatol. 2000 Aug;43(2 Pt 2):386-90 [10901731.001]
  • [Cites] Arch Dermatol Res. 1985;278(1):74-6 [2937373.001]
  • [Cites] N Engl J Med. 1987 Dec 17;317(25):1582-7 [2825016.001]
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  • [Cites] Clin Endocrinol (Oxf). 1990 Jun;32(6):769-80 [2116946.001]
  • [Cites] Am J Med. 1995 Dec;99(6):662-71 [7503090.001]
  • (PMID = 19830233.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2737766
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3. Nikkels AF, Piérard GE: Cryoscopy: a novel enhancing method of in vivo skin imaging. Skin Res Technol; 2007 Nov;13(4):377-84
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  • Cryoscopy patterns of normal skin, callosities and of histologically proven seborrheic keratoses, verrucous hamartomas, molluscum contagiosum, keratoacanthomas, viral warts, condylomas, actinic keratoses, dermatofibromas, skin tags, basal cell carcinomas, angiomas, and melanocytic naevi were assessed.
  • Every single examined normal skin site and all the skin lesions showed a strong whitening effect, except heavily cornified structures, including some keratoses, callosities, and viral warts.
  • [MeSH-minor] Adult. Color. Dermatitis, Seborrheic / pathology. Electric Capacitance. Humans. Keratosis / pathology. Middle Aged. Nevus / pathology. Nitrogen

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  • (PMID = 17908188.001).
  • [ISSN] 0909-752X
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] N762921K75 / Nitrogen
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4. Pusiol T, Zorzi MG, Morichetti D: Extracutaneous seborrheic inclusion cyst: an unusual presentation. Pathologica; 2010 Oct;102(5):420-2
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  • [Title] Extracutaneous seborrheic inclusion cyst: an unusual presentation.
  • Seborrheic inclusion cyst is an unusual variant of epidermal cyst characterized by parietal histology similar to seborrheic keratosis.
  • Cysts with such changes have been called "seborrheic keratosis-like changes in epidermal cyst" or "epidermoid cyst with seborrheic verruca-like cyst wall" or simply "seborrheic cyst".
  • We describe the first case of an extracutaneous seborrheic inclusion cyst arising from round ligament.
  • A 30-year-old female was referred to our institution for abdominal pain.
  • Histologically, the cystic wall was lined by a stratified squamous epithelium with a granular cell layer.
  • The present case is unique in that it is the first reported case of an extracutaneous seborrheic inclusion cyst arising from a very unusual site, namely the round ligament.
  • [MeSH-major] Adnexal Diseases / pathology. Dermatitis, Seborrheic / pathology. Epidermal Cyst / pathology. Keratosis, Seborrheic / pathology

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  • (PMID = 21361125.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Tseng SH, Huang YH, Chao SC, Lee JY, Chang KC: Conjunctival seborrheic keratosis. Ophthalmology; 2010 Jan;117(1):190-190.e2
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  • [Title] Conjunctival seborrheic keratosis.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Aged. Biomarkers / metabolism. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / metabolism. Conjunctival Neoplasms / surgery. Diagnosis, Differential. Female. Humans. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / surgery. Ophthalmologic Surgical Procedures

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  • (PMID = 20114109.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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6. Hafner C, Vogt T: Seborrheic keratosis. J Dtsch Dermatol Ges; 2008 Aug;6(8):664-77
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  • [Title] Seborrheic keratosis.
  • Seborrheic keratosis is one of the most common skin tumors.
  • Despite its frequency, many aspects of seborrheic keratosis remain elusive.
  • In the last years new molecular genetic insights into seborrheic keratoses have been gained.
  • The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized.
  • [MeSH-major] Clinical Trials as Topic / trends. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / therapy


7. Macaya-Pascual A, López-Canós R, López-Piqueras S, Gómez S: [Analysis of the reasons for consultation and dermatology care cost in a primary care site]. Actas Dermosifiliogr; 2006 Nov;97(9):569-72
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  • [Transliterated title] Análisis de los motivos de consulta y de su coste en la asistencia dermatológica en un centro de Atención Primaria.
  • Endpoints of age, gender, diagnosis, cost per visit, cryotherapy and electrocoagulation were collected.
  • In the latter group, the diagnoses were: seborrheic keratosis 39/455 (9 %), acrocordons 21/455 (5 %), remaining diagnoses (intradermal melanocytic nevi, cherry angioma, solar lentigos): 56/116 (11 %).

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  • [CommentIn] Actas Dermosifiliogr. 2007 Sep;98(7):510-1 [17669312.001]
  • (PMID = 17173759.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Li P, Gao XH, Chen HD, Zhang Y, Wang Y, Wang H, Wang Y, Xie Y: Localization of haptoglobin in normal human skin and some skin diseases. Int J Dermatol; 2005 Apr;44(4):280-4
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  • Haptoglobin can also be detected in the cytoplasm of normal epidermal Langerhans cells (LCs), and can prevent their functional maturation.
  • METHODS: We examined Hp expression at mRNA and protein levels by in situ hybridization and immunohistochemistry, respectively, in normal human skin and in the skin of patients with psoriasis, lichen planus, erythroderma, seborrheic keratosis, verruca vulgaris, basal cell carcinoma, systemic lupus erythematosus, pemphigus and bullous pemphigoid. RESULTS:.
  • (1) Haptoglobin mRNA was expressed in the epidermal keratinocytes (KCs), the epithelial cells of hair follicles, sebaceous glands and eccrine glands in normal skin and all dermatoses investigated. (2) Whereas compared with normal skin, the Hp mRNA in KCs of patients with psoriasis, lichen planus, erythroderma, seborrhoea keratosis and verruca vulgaris was significantly intensified, it was weaker in patients with systemic lupus erythematosus, pemphigus and bullous pemphigoid. (3) Haptoglobin protein only stained positively in some KCs of patients with psoriasis, lichen planus and erythroderma. (4) Although some but not all epidermal LCs were positively stained with anti-Hp antibody in normal skin and in skin samples from all patients, the ratios of Hp-positive LCs/total LCs were significantly higher in those diseases with intensified Hp mRNA in KCs.
  • The expression of Hp mRNA in KCs and the Hp protein in both LCs and KCs appears to be correlated with the amount of inflammation, which might indicate that skin itself is involved in down-regulating the local inflammatory reaction by KC-synthesized Hp.

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  • (PMID = 15811077.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Haptoglobins
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9. Naruke Y, Nakashima M, Suzuki K, Matsuu-Matsuyama M, Shichijo K, Kondo H, Sekine I: Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability. Cancer Sci; 2008 May;99(5):946-51
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  • The levels of GIN were analyzed by immunofluorescence studies of 53BP1 in 56 skin tumors that included 20 seborrheic keratosis, eight actinic keratosis, nine Bowen's disease, nine squamous cell carcinoma, and 10 basal cell carcinoma.
  • Because actinic keratosis showed a high DDR type of 53BP1 immunoreactivity, GIN seems to be induced at the precancerous stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Nucleus / metabolism. Epidermis / metabolism. Female. Fluorescent Antibody Technique. Gene Expression. Humans. Male. Middle Aged

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  • (PMID = 18380789.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human
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10. Ko CJ, Shintaku P, Binder SW: Comparison of benign keratoses using p53, bcl-1, and bcl-2. J Cutan Pathol; 2005 May;32(5):356-9
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  • [Title] Comparison of benign keratoses using p53, bcl-1, and bcl-2.
  • While cell-cycle markers have been used to differentiate benign vs. malignant lesions and to classify malignant lesions, benign keratoses have not been well studied using such markers.
  • We hypothesized that inflammation or irritation of benign keratoses may be related to a shift in the cell cycle.
  • We compared the immunohistochemical staining patterns of 10 seborrheic keratoses (SKs), 10 inflamed seborrheic keratoses (iSKs), and 10 inverted follicular keratoses (IFKs) using antibodies to p53, bcl-1, and bcl-2.
  • Staining with antibodies to p53 was slightly increased in IFKs compared with iSKs or non-inflamed seborrheic keratoses.
  • Keratinocyte bcl-2 staining was significantly higher in SKs compared with the other two keratoses.
  • [MeSH-major] Cyclin D1 / metabolism. Keratosis / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Biomarkers / metabolism. Cell Cycle. Darier Disease / metabolism. Humans. Immunohistochemistry / methods. Inflammation / metabolism. Keratosis, Seborrheic / metabolism. Staining and Labeling. Tissue Distribution

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  • (PMID = 15811121.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
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11. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • Serial sections and immunohistochemical (IHC) analysis for CK17 and human papilloma virus (HPV) were performed on available materials.
  • Mean age at diagnostic was 56 years.
  • The lesions associated with TB were inverted follicular keratosis (IFK) in three cases, seborrhoeic keratosis (SK) in two cases and IFK with verruca vulgaris pattern in one case.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • The association of TB and IFK with direct connection between the lesions is another argument in favor of the follicular origin of IFK.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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12. Braga JC, Scope A, Klaz I, Mecca P, Spencer P, Marghoob AA: Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis. J Am Acad Dermatol; 2008 May;58(5):875-80
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  • [Title] Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis.
  • Seborrheic keratosis is a common skin lesion that can usually be recognized either clinically or dermoscopically.
  • However, melanomas mimicking seborrheic keratoses, as well as melanomas arising in association with seborrheic keratoses, have been described.
  • We report the case of a patient with a lesion that initially revealed "classic" dermoscopic features of a seborrheic keratosis.
  • However, during follow-up, changes in color developed within the center of the lesion that led the clinician to the correct diagnosis of melanoma.
  • Dermatologists should be cognizant of "errors in perception"; we suggest that a final dermoscopic judgment of a seborrheic keratosis be rendered by combining the gestalt diagnosis of the overall pattern, with deliberate dermoscopic analysis of all quadrants of the lesion.
  • [MeSH-major] Diagnostic Errors. Head and Neck Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis


13. Graells J, Espinola A, Barrio C, Muñoz MD, Román A, Parellada N: [Minor cutaneous ambulatory surgery and cryotherapy. Comparative study between a dermatologist and family physicians]. Actas Dermosifiliogr; 2007 Apr;98(3):171-7
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  • [Transliterated title] Cirugía menor ambulatoria dermatológica y crioterapia. Estudio comparativo entre un dermatólogo y médicos de familia.
  • This study compares the diagnosis and treatment in cutaneous surgery, including cryotherapy, between a dermatologist and family physicians.
  • Each lesion was independently evaluated by a dermatologist and a family physician, both of whom assigned the clinical diagnosis and therapeutic advice.
  • Concordance for diagnosis, recommended treatment and indication for cryotherapy was calculated by Cohen's kappa coefficient.
  • Diagnostic concordance was significantly better for melanocytic nevus, achrocordon and for lesions with multiple and monomorphous presentation, and worse for isolated pigmented lesions.
  • For recommended treatment concordance was better for multiple and monomorphous lesions and worse for skin cancer and seborrheic keratosis.
  • For indication of cryotherapy concordance was worse for skin cancer, melanocytic nevus, acrochordon and seborrheic keratosis.
  • Family physicians should be more careful in evaluating solitary pigmented lesions and patients at risk for skin cancer.
  • [MeSH-major] Ambulatory Surgical Procedures. Cryotherapy. Dermatology. Family Practice. Observer Variation. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Clinical Competence. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / surgery. Keratosis, Seborrheic / therapy. Male. Middle Aged. Nevus, Pigmented / diagnosis. Nevus, Pigmented / surgery. Nevus, Pigmented / therapy. Prospective Studies. Sampling Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery. Skin Neoplasms / therapy. Warts / diagnosis. Warts / surgery. Warts / therapy

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  • (PMID = 17504701.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
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14. Fukushige T, Kanekura T, Ohuchi E, Shinya T, Kanzaki T: Immunohistochemical studies comparing the localization of type XV collagen in normal human skin and skin tumors with that of type IV collagen. J Dermatol; 2005 Feb;32(2):74-83
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  • It was expressed at low levels in seborrheic keratosis and not expressed at all in actinic keratosis and squamous cell carcinoma.
  • [MeSH-minor] Basement Membrane / metabolism. Carcinoma, Squamous Cell / metabolism. DNA, Complementary / analysis. Humans. Immunohistochemistry. Keratosis / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism

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  • (PMID = 15906535.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA, Complementary; 9007-34-5 / Collagen
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15. Kopf AW, Rabinovitz H, Marghoob A, Braun RP, Wang S, Oliviero M, Polsky D: "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses. J Am Acad Dermatol; 2006 Dec;55(6):1089-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses.
  • "Fat fingers" are thick digitate linear, curvilinear, branched, or oval/circular dermoscopic structures typically seen in seborrheic keratoses where they represent the gyri of their cerebriform surfaces.
  • Their recognition is very useful in the diagnosis of these lesions, especially when the classic features (eg, milia, comedo-like openings) are absent.
  • Histologically and by confocal microscopy the "fat finger" gyri are accentuated by pigmented keratin filling the sulci.
  • "Fat fingers" must be differentiated from other linear structures such as "network-like structures"; branched streaks; network; globules; pigmented ovoid-nests; and streaks/pseudopods seen in different melanocytic and non-melanocytic lesions.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis

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  • (PMID = 17097405.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ansai S, Kimura T: Rippled-pattern sebaceoma: a clinicopathological study. Am J Dermatopathol; 2009 Jun;31(4):364-6
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  • Eighty cases of sebaceoma, comprising 37 male and 43 female patients with a mean age at resection of 62.9 +/- 17.0 years, were reviewed.
  • Histopathologically, sebaceoma without rippled pattern frequently associated with other neoplastic lesions including sebaceous nevus, seborrheic keratosis, and trichoblastoma on the same lesion; however, there were no associated lesions in rippled-pattern sebaceoma.

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  • (PMID = 19461240.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Cribier B: [Seborrheous keratosis]. Ann Dermatol Venereol; 2005 Mar;132(3):292-5
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  • [Title] [Seborrheous keratosis].
  • [MeSH-major] Keratosis, Seborrheic / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 15924060.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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18. Bernard-Pierrot I, Brams A, Dunois-Lardé C, Caillault A, Diez de Medina SG, Cappellen D, Graff G, Thiery JP, Chopin D, Ricol D, Radvanyi F: Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis; 2006 Apr;27(4):740-7
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  • Surprisingly, identical somatic activating mutations have been found at the somatic level in tumours: at high frequency in benign epithelial tumours (seborrheic keratosis, urothelial papilloma) and in low-grade, low-stage urothelial carcinomas, and at a lower frequency in other types of urothelial carcinoma, in cervix carcinoma, and in haematological cancer, multiple myeloma.
  • NIH-3T3 cells transfected with a mutated form of FGFR3b--FGFR3b-S249C, the most common mutation in bladder tumours--presented a spindle-cell morphology, grew in soft agar and gave rise to tumours when xenografted into nude mice.
  • We identified one line of 17 bladder cell lines tested (MGH-U3) that expressed a mutated form of FGFR3b, FGFR3b-Y375C.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Urinary Bladder Neoplasms / genetics

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  • (PMID = 16338952.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Pyrroles; 0 / RNA, Small Interfering; 0 / SU 5402; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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19. Hafner C, Toll A, Fernández-Casado A, Earl J, Marqués M, Acquadro F, Méndez-Pertuz M, Urioste M, Malats N, Burns JE, Knowles MA, Cigudosa JC, Hartmann A, Vogt T, Landthaler M, Pujol RM, Real FX: Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A; 2010 Nov 30;107(48):20780-5
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  • Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Keratosis, Seborrheic / pathology. Mutation / genetics. Oncogenes / genetics
  • [MeSH-minor] Apoptosis / genetics. Biomarkers, Tumor. Cell Aging. Cell Proliferation. Clone Cells. DNA Mutational Analysis. Genetic Testing. Genome, Human / genetics. Genotype. Humans. Mitogen-Activated Protein Kinases / genetics. PTEN Phosphohydrolase / metabolism. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins c-akt / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Signal Transduction / genetics. TOR Serine-Threonine Kinases / metabolism. Tumor Suppressor Proteins / metabolism. ras Proteins / genetics


20. Keskin EA, Gorpelioglu C, Sarifakioglu E, Kafali H: Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report. Cases J; 2010;3:56
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  • [Title] Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report.
  • Seborrheic keratoses, a benign growth lesion, is a very common cutaneous lesion encountered in white races in the fourth and fifth decade.
  • A 34-year-old woman reported with a hyperpigmented palpable lesion, approximately 5-10 mm in diameter, was found on the patient's left labium majus.
  • The clinical differential diagnosis of the pigmented lesions of the vulva is difficult often need a biopsy.

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  • [Cites] Dermatol Clin. 1992 Apr;10(2):361-70 [1606765.001]
  • [Cites] Clin Exp Dermatol. 2005 Jan;30(1):17-9 [15663494.001]
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  • (PMID = 20181151.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2834621
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21. Birnie AJ, Varma S: A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis. Clin Exp Dermatol; 2008 Jul;33(4):512-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic. Dermoscopy / methods. Humans. Male. Treatment Outcome

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  • [CommentIn] Clin Exp Dermatol. 2009 Oct;34(7):e371-2 [19486048.001]
  • (PMID = 18462448.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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22. Briscoe C: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977073.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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23. Dreyer J: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977071.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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24. Stelkovics E, Korom I, Marczinovits I, Molnar J, Rasky K, Raso E, Ficsor L, Molnar B, Kopper L, Krenacs T: Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy. Appl Immunohistochem Mol Morphol; 2008 Oct;16(5):433-41
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  • [Title] Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy.
  • In this work, highly sensitive monoclonal antibodies 6D1 and 9G2 were produced, characterized, and used for the detection of collagen XVII in a tissue microarray series of archived samples of nonmelanocytic epithelial neoplasias, including 5 verruca vulgaris, 14 seborrheic keratosis, 38 actinic keratosis, 38 basal cell carcinoma (BCC), 15 basosquamous carcinoma, 58 squamous cell carcinoma (SCC), and 9 normal skin.
  • In normal skin and benign epidermal lesions, collagen XVII protein was restricted to basal keratinocytes.
  • Collagen XVII immunostaining of atypical keratinocytes in most actinic/solar keratosis supports the view of their malignancy and common origin with SCC.
  • Squamous component of basosquamous carcinoma showed moderate reaction, whereas islets of BCC were mainly negative reflecting the diverse genotype and phenotype, and pathogenesis of SCC and BCC.

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  • (PMID = 18633319.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Autoantigens; 0 / Biomarkers, Tumor; 0 / Non-Fibrillar Collagens; 0 / collagen type XVII
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25. Samson M, Audia S, Georges M, Collet E, Camus C, Camus P, Bonniaud P: [A rash. Seborrheic keratosis]. Rev Med Interne; 2010 Mar;31(3):236-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rash. Seborrheic keratosis].

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  • (PMID = 19299050.001).
  • [ISSN] 1768-3122
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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26. Resnik KS: Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. Am J Dermatopathol; 2008 Jun;30(3):300-1
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  • [Title] Granular parakeratotic acanthoma is not adenoid seborrheic keratosis.
  • [MeSH-major] Acanthoma / diagnosis. Dermatitis, Seborrheic / diagnosis. Diagnostic Errors. Parakeratosis / diagnosis. Skin Neoplasms / diagnosis


27. Affleck AG, Perkins W: Fake tan as a cause of a change in a pigmented lesion: seborrhoeic keratosis or melanocytic naevus. Clin Exp Dermatol; 2008 Jan;33(1):105-6
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  • [Title] Fake tan as a cause of a change in a pigmented lesion: seborrhoeic keratosis or melanocytic naevus.
  • [MeSH-major] Dihydroxyacetone / adverse effects. Hyperpigmentation / chemically induced. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17983450.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] O10DDW6JOO / Dihydroxyacetone
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28. de Giorgi V, Massi D, Salvini C, Mannone F, Carli P: Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study. Clin Exp Dermatol; 2005 Jan;30(1):17-9
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  • [Title] Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study.
  • The diagnosis of seborrheic keratosis is, in general, a clinical one, but in some cases, the differential diagnosis between pigmented seborrheic keratosis and malignant melanoma is difficult.
  • Dermoscopy may improve the early diagnosis of vulvar melanoma and thus play a role in the preoperative classification of pigmented lesions at this particular site.
  • We report the first case of a pigmented seborrheic keratosis of the vulva clinically mimicking a malignant melanoma, whose dermoscopic features have been investigated together with their pathologic correlates.
  • Dermoscopy is therefore a useful method for the differential diagnosis of pigmented lesions even in the vulva.
  • [MeSH-major] Dermoscopy / standards. Keratosis, Seborrheic / pathology. Melanoma / pathology. Vulvar Diseases / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Dermatology / methods. Diagnosis, Differential. Female. Humans

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  • (PMID = 15663494.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Walsh SN, Hurt MA, Santa Cruz DJ: Psoriasiform keratosis. Am J Dermatopathol; 2007 Apr;29(2):137-40
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  • [Title] Psoriasiform keratosis.
  • Presented herein are 18 cases of erythematous, scaly papules or plaques with microscopic features of both seborrheic keratosis and psoriasis.
  • There was, however, no known clinical diagnosis of psoriasis in any patient, neither at initial presentation nor on follow-up examination.
  • The mean age at diagnosis was 66.8 years.
  • The most common diagnoses, clinically, were seborrheic keratosis, followed by basal cell carcinoma, Bowen's disease, actinic (solar) keratosis, and squamous cell carcinoma, among others.
  • Histologic examination revealed irregular verrucous epidermal acanthosis, with hyperkeratosis, parakeratosis, hypergranulosis, and intracorneal collections of neutrophils, often in alternating tiers.
  • We have coined the term psoriasiform keratosis as a provisional appellation until the nature of these lesions is determined more definitively.
  • It is unclear whether a psoriasiform keratosis is a rudimentary manifestation of psoriasis or a lesion sui generis.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Psoriasis / pathology. Skin / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lichenoid Eruptions / pathology. Lymphocytes / pathology. Male. Middle Aged. Neutrophils / pathology. Prospective Studies. Terminology as Topic. Time Factors

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  • (PMID = 17414434.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Xhauflaire-Uhoda E, Piérard GE: Contrasted skin capacitance imaging of seborrheic keratoses and melanocytic nevi. Dermatology; 2006;212(4):394-7
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  • [Title] Contrasted skin capacitance imaging of seborrheic keratoses and melanocytic nevi.
  • [MeSH-major] Electric Capacitance. Electrodiagnosis / instrumentation. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 16707896.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] Switzerland
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31. Swanson DL, Laman SD, Biryulina M, Nielsen KP, Ryzhikov G, Stamnes JJ, Hamre B, Zhao L, Castellana FS, Stamnes K: Optical transfer diagnosis of pigmented lesions: a pilot study. Skin Res Technol; 2009 Aug;15(3):330-7
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  • [Title] Optical transfer diagnosis of pigmented lesions: a pilot study.
  • OBJECTIVE: To evaluate the potential of a novel imaging technology, optical transfer diagnosis (OTD), for differentiation of benign from malignant pigmented melanocytic lesions.
  • DESIGN: Patients with pigmented lesions suspicious for melanoma were referred for OTD.
  • To create morphologic-physiologic maps, the imaging system used the morphologic and physiologic parameters derived from prediction models of light absorption and scattering by chromophores such as hemoglobin, keratin, and melanin at different epidermal and dermal depths.
  • INTERVENTION: OTD of pigmented lesions suspicious for melanoma, followed by biopsies for histopathologic examination.
  • RESULTS: Sixty-three pigmented suspicious lesions were scanned before being biopsied for histopathologic examination by the two dermatopathologists.
  • Of the 63 lesions, five were identified as melanoma and 58 were found to be benign (including three seborrheic keratoses and 55 melanocytic nevi).
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / diagnosis. Pigmentation Disorders / diagnosis. Skin Neoplasms / diagnosis. Spectrum Analysis / methods

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  • (PMID = 19624430.001).
  • [ISSN] 1600-0846
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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32. Adenis JP, Sabatier A, Robert PY: [Tumors of the eyelids in the elderly]. J Fr Ophtalmol; 2006 Jun;29(6):687-93
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  • The clinical aspect of tumors of the eyelids is polymorphous; however, the most frequent are benign tumors such as papillomas, basal cell carcinoma, squamous cell carcinoma, meibomian gland carcinoma, and melanomas.
  • For the most malignant tumors such as malignant melanoma and Merkel cell tumor, lymph sentinel biopsy is a recent, valuable tool, but its benefit needs to be confirmed in large series.
  • [MeSH-major] Eyelid Neoplasms / diagnosis

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  • (PMID = 16885901.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 13
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33. Hatta N, Hirano T, Kimura T, Hashimoto K, Mehregan DR, Ansai S, Takehara K, Takata M: Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol; 2005 Feb;32(2):131-6
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  • [Title] Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
  • BACKGROUND: Distinguishing basal cell carcinoma (BCC) from other benign and malignant skin tumors is sometimes a difficult task for the pathologists.
  • Because the activation of hedgehog signals and the up-regulation of its critical transcriptional factor Gli1 are well documented in BCC, a molecular technique measuring Gli1 transcripts may aide the diagnosis.
  • The tumors included BCC (21), squamous cell carcinoma (13), seborrheic keratoses (8), trichoepithelioma (5), eccrine poroma/porocarcinoma (4), and sebaceous epithelioma/carcinoma (2).
  • The diagnosis was discordant among three pathologists in the remaining 15 tumors.
  • Histological diagnoses included BCC, BCC with sebaceous differentiation, sebaceoma/sebaceous epithelioma, trichoblastoma, trichoepithelioma, basaloid follicular harmartoma, basosquamous carcinoma, etc.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Oncogene Proteins / metabolism. Skin Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription, Genetic

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  • (PMID = 15606671.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gli protein; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / Transcription Factors
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34. Burkhart CG, Burkhart CN: Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses. Skinmed; 2008 Jan-Feb;7(1):15-8
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  • [Title] Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses.
  • BACKGROUND: Seborrheic keratoses are the most common benign tumors in adults.
  • METHODS: A topical 50% urea-containing product under occlusion was applied daily to large and/or thick hyperkeratotic seborrheic keratoses on the truck and extremities.
  • CONCLUSIONS: Hyperkeratotic seborrheic keratoses can be satisfactorily managed with topical agents and scraping with reasonable patient satisfaction.
  • [MeSH-major] Keratolytic Agents / administration & dosage. Keratosis, Seborrheic / drug therapy. Occlusive Dressings

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  • (PMID = 18174808.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratolytic Agents
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35. Mitsuhashi Y, Kawaguchi M, Hozumi Y, Kondo S: Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis. J Dermatol; 2005 Jun;32(6):420-3
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  • [Title] Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis.
  • Senile wart or seborrheic keratosis is a benign tumor which occurs mainly in the elderly.
  • We treated senile warts with topical vitamin D3 ointments (tacalcitol, calcipotriol or maxacalcitol).
  • An organ culture experiment using senile wart as a material with several concentrations of tacalcitol revealed that tacalcitol induced apoptosis in the tissue.
  • Vitamin D3 may affect senile warts by inducing apoptosis.
  • Clearance of senile warts, especially on exposed areas without pain, may improve the quality of life (QOL) of the elderly.
  • [MeSH-major] Cholecalciferol / therapeutic use. Keratosis, Seborrheic / drug therapy. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Administration, Topical. Adult. Age Factors. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies. Severity of Illness Index. Treatment Outcome

  • Hazardous Substances Data Bank. CHOLECALCIFEROL .
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  • (PMID = 16043912.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1C6V77QF41 / Cholecalciferol
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36. Steele CL, Shea CR, Petronic-Rosic V: Epidermolytic hyperkeratosis within infundibular cysts. J Cutan Pathol; 2007 Apr;34(4):360-2
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  • [Title] Epidermolytic hyperkeratosis within infundibular cysts.
  • Epidermolytic hyperkeratosis (EH) is a well-described histopathologic pattern characteristic of bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis.
  • EH has been observed as an incidental finding in tissue adjacent to and within lesions such as nevi, scars, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and seborrheic keratoses.
  • We present two cases of EH within infundibular type follicular cysts, a rare finding only once otherwise reported in 1978.
  • [MeSH-major] Epidermal Cyst / complications. Epidermal Cyst / pathology. Hyperkeratosis, Epidermolytic / complications. Hyperkeratosis, Epidermolytic / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / complications. Carcinoma, Squamous Cell / complications. Female. Humans. Incidental Findings. Male. Skin Neoplasms / complications

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  • (PMID = 17381810.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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37. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • [Title] Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants.
  • AIMS: Seborrheic keratoses are the most common benign cutaneous neoplasms in adult and middle-age patients.
  • There are six distinctive histopathologic variants of seborrheic keratosis, namely, acanthotic or solid, reticulated or adenoid, hyperkeratotic or papillomatous, clonal or nested, irritated and inflamed.
  • METHODS: We report two additional histopathologic variants of seborrheic keratosis.
  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • DISCUSSION: To our knowledge, these two histopathologic variants of seborrheic keratosis have been not previously described in the literature.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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38. Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Ostano P, Dummer R, Brissette JL, Dotto GP: A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest; 2009 Oct;119(10):3127-37
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  • [Title] A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.
  • Seborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarely, progress into malignancy, for reasons that are not understood.
  • We investigated this by gene expression profiling of human SKs and cutaneous squamous cell carcinomas (SCCs) and found that several genes previously connected with keratinocyte tumor development were similarly modulated in SKs and SCCs, whereas the expression of others differed by only a few fold.

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  • (PMID = 19729838.001).
  • [ISSN] 1558-8238
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR39190; United States / NCI NIH HHS / CA / CA16038; United States / NIAMS NIH HHS / AR / R01 AR045284; United States / NIAMS NIH HHS / AR / AR054856; United States / NCI NIH HHS / CA / R01 CA073796; United States / Intramural NIH HHS / / ZIA AG000378-03; United States / NIAMS NIH HHS / AR / AR045284-11A1; United States / NIAMS NIH HHS / AR / R01 AR045284-11A1; United States / NIAMS NIH HHS / AR / R01 AR039190; United States / NIAMS NIH HHS / AR / R01 AR055218-02; United States / NCI NIH HHS / CA / P01 CA016038; United States / NCI NIH HHS / CA / CA73796; United States / NIAMS NIH HHS / AR / AR055218-02; United States / NIAMS NIH HHS / AR / AR045284; United States / NIAMS NIH HHS / AR / R01 AR055218; United States / NIAMS NIH HHS / AR / R01 AR054856
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Whn protein; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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39. Zaballos P, Martí E, Cuéllar F, Puig S, Malvehy J: Dermoscopy of lichenoid regressing seborrheic keratosis. Arch Dermatol; 2006 Mar;142(3):410
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  • [Title] Dermoscopy of lichenoid regressing seborrheic keratosis.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / pathology. Lichenoid Eruptions / pathology

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  • (PMID = 16549732.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Ramot Y, Maly A, Zlotogorski A, Nanova K: Atypical "allergic crease". J Dermatol Case Rep; 2010 Dec 19;4(3):36-7
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  • MAIN OBSERVATION: We describe an 18-year-old man with allergic rhinitis, who developed cornified papules along an allergic crease.
  • Histopathology revealed seborrheic keratosis like hyperplasia, accompanied by horn cysts.

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  • (PMID = 21886747.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157813
  • [Keywords] NOTNLM ; allergic crease / allergic rhinitis / dermoscopy / pediatric dermatology / seborrheic keratosis like hyperplasia
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41. Lebedeva IuV, Davydov AB, Lebedev SN: [Clinical evaluation of prevalence of seborrheic keratosis of face and neck skin among oncological patients]. Stomatologiia (Mosk); 2009;88(5):45-8
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  • [Title] [Clinical evaluation of prevalence of seborrheic keratosis of face and neck skin among oncological patients].
  • The aim was to detect seborrheal keratosis of face and neck in these patients.
  • 280 patient of given age group of maxillo-facial department were controls.
  • Two fold increase in the presence of seborrheal keratosis of face and neck in oncologic patients was found as compared to control group.
  • [MeSH-major] Facial Dermatoses / epidemiology. Keratosis, Seborrheic / epidemiology. Neck. Neoplasms / complications
  • [MeSH-minor] Age Factors. Female. Humans. Male. Middle Aged. Sex Factors. Skin / pathology

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  • (PMID = 20037539.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii︠a︡
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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42. Ambro CM, Humphreys TR, Lee JB: Epidermotropically metastatic pancreatic adenocarcinoma. Am J Dermatopathol; 2006 Feb;28(1):60-2
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  • Neoplastic glandular structures that varied in size and shape containing abundant mucin within the lumens and in the neoplastic cells were present within a seborrheic keratosis and adjacent normal epidermis.
  • The patient's history of pancreatic mucinous ductal adenocarcinoma and immunohistochemical staining pattern of carbohydrate antigen 19-9 (CA 19-9) confirmed the diagnosis.

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  • (PMID = 16456328.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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43. Oyama N, Kaneko F: Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review. J Dermatol; 2008 Dec;35(12):782-5
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  • [Title] Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review.
  • The secondary skin malignancies arising in seborrheic keratosis (SK) are uncommon, and the causal association between the pre-existing lesion and subsequent malignant transformation remains uncertain.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Hair Diseases / pathology. Keratosis, Seborrheic / complications. Skin Neoplasms / pathology


44. Uhlenhake EE, Sangueza OP, Lee AD, Jorizzo JL: Spreading pigmented actinic keratosis: a review. J Am Acad Dermatol; 2010 Sep;63(3):499-506
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spreading pigmented actinic keratosis: a review.
  • INTRODUCTION: Spreading pigmented actinic keratosis (SPAK) is a common, but uncommonly reported or appreciated, variant of classic actinic keratosis (AK).
  • It can mimic different pigmented lesions, which may be benign (eg, solar lentigo) or malignant (eg, lentigo maligna).
  • METHODS: A literature search was performed in both PubMed and MEDLINE databases using the search terms "spreading pigmented actinic keratosis," "pigmented solar keratosis," "pigmented actinic," and "pigmented solar."
  • RESULTS: SPAK is a rarely reported lesion that can be difficult to distinguish from other benign and malignant pigmented lesions, including seborrheic keratosis, melanoma in situ (lentigo maligna type), and lentigo maligna melanoma.
  • Pathologically, the lesion resembles classic AK with increased basal melanization.
  • CONCLUSIONS: SPAK can be associated with adjacent melanoma in situ; therefore, its diagnosis merits increased suspicion for coexisting melanoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hutchinson's Melanotic Freckle / pathology. Keratosis, Actinic / pathology. Precancerous Conditions / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Dermoscopy / methods. Diagnosis, Differential. Disease Progression. Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment


45. Zaballos P, Ara M, Puig S, Malvehy J: Clinical and dermoscopic image of an intermediate stage of regressing seborrheic keratosis in a lichenoid keratosis. Dermatol Surg; 2005 Jan;31(1):102-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and dermoscopic image of an intermediate stage of regressing seborrheic keratosis in a lichenoid keratosis.
  • [MeSH-major] Keratosis / pathology. Keratosis, Seborrheic / pathology. Lichen Planus / pathology

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  • (PMID = 15720105.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Lally A, Casabonne D, Waterboer T, Imko-Walczuk B, Michael KM, Pawlita M, Newton R, Wojnarowska F: Association of seborrhoeic warts with skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):302-7
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  • [Title] Association of seborrhoeic warts with skin cancer in renal transplant recipients.
  • A clinical observation that RTR with skin cancer often had multiple seborrhoeic warts prompted an investigation in RTR into the relationship between seborrhoeic warts and skin cancer and an exploration into potential risk factors for seborrhoeic warts in this population, including infection with human papillomavirus (HPV).
  • Clinical examinations identified seborrhoeic warts.
  • Odds ratios (OR) calculated using unconditional logistic regression analysis to look for associations between skin cancer, HPV infection and seborrhoeic warts, controlling for potential confounding factors of gender, age and time since transplantation.
  • RESULTS: Seborrhoeic warts were associated with non-melanoma skin cancer [OR = 3.7; 95% confidence intervals (CI) ranging from 1.6-8.9; P = 0.002] when confounding factors of gender, age and time since transplantation were controlled for.
  • There was also an association between seborrhoeic warts and viral warts (OR = 3.0, CI: 1.6-5.4; P < 0.0001), but no association between seborrhoeic warts and infection with single or multiple HPV types.
  • CONCLUSIONS: Seborrhoeic warts are associated with cutaneous malignancy, but not with any of the HPV types tested.
  • RTR with multiple seborrhoeic warts may require more regular cutaneous examination to monitor for early signs of skin cancer.
  • [MeSH-major] Dermatitis, Seborrheic / complications. Kidney Transplantation / adverse effects. Skin Neoplasms / etiology. Warts / complications


47. Halleck P, Loddenkemper C, Hummel M, Scherer H, Haisch A: [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description]. HNO; 2009 May;57(5):480-3
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  • [Title] [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description].
  • [Transliterated title] Hyperkeratotische invertierte seborrhoische Keratose des äusseren Gehörgangs : Eine Erstbeschreibung.
  • Seborrheic keratosis is one of the most common benign neoplasms seen at the trunk, extremities, head and neck of older individuals which rarely occurs in the auditory canal.
  • Even rarer is the occurrence of an inverted or hyperkeratotic variant in this localization.
  • We present the clinical picture of a 74-year-old man with a recurrent hyperkeratotic, partially inverted seborrheic keratosis of the right external auditory canal.
  • This disease is sometimes difficult to diagnose, particulary to mark down malignant lesions.
  • An uncritical diagnosis must be avoided, since these lesions and especially the irritated subtype might be falsely assessed as basal cell carcinomas which they may resemble histologically.
  • [MeSH-major] Ear Diseases / diagnosis. Ear, External / pathology. Keratosis, Seborrheic / diagnosis

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  • [Cites] Otolaryngol Head Neck Surg. 1987 Feb;96(2):198-201 [2960940.001]
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  • (PMID = 17468841.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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48. Schulz H: [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?]. Hautarzt; 2010 Dec;61(12):1061-2
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  • [Title] [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?].
  • [Transliterated title] Pigmentierte Läsion der Schläfenregion. Melanozytärer Tumor, Basalzellkarzinom oder irritierte seborrhoische Keratose?
  • 33-year-old woman with a red-brown plaque on the temple.
  • Histopathological diagnosis revealed an irritated seborrheic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Facial Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adult. Biopsy. Dermoscopy. Diagnosis, Differential. Female. Forehead. Humans. Skin / pathology

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  • [Cites] Dermatol Clin. 2001 Apr;19(2):347-57 [11556243.001]
  • [Cites] Arch Dermatol. 2002 Dec;138(12):1556-60 [12472342.001]
  • (PMID = 21069503.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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49. Kullander J, Forslund O, Dillner J: Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev; 2009 Feb;18(2):472-8
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  • [Title] Staphylococcus aureus and squamous cell carcinoma of the skin.
  • Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought.
  • We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with biopsies from healthy skin of these 353 immunocompetent patients.
  • In a S. aureus-specific PCR, targeting the nuc gene, presence of S. aureus DNA was strongly associated with SCC (29.3% positive specimens; adjusted odds ratio, 6.23; 95% confidence interval, 3.10-12.53) compared with healthy skin (5.7% positive specimens).
  • There was also a tendency for association of S. aureus with actinic keratosis, but no association was found for basal cell carcinoma or seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Squamous Cell / microbiology. Staphylococcus aureus / isolation & purification
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / microbiology. Case-Control Studies. DNA, Bacterial / analysis. Female. Humans. Keratosis, Actinic / microbiology. Keratosis, Seborrheic / microbiology. Logistic Models. Male. Middle Aged. Polymerase Chain Reaction. Precancerous Conditions / microbiology

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  • (PMID = 19155437.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial
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50. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y, Furue M: Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol; 2009 Feb;160(2):442-5
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  • BACKGROUND: The enzyme mammalian target of rapamycin (mTOR) integrates many different cellular signals to control cell growth and proliferation, protein synthesis and breakdown, and other processes.
  • To date, there has been no report on the expression of protein kinase B (AKT)/mTOR cell signalling in epidermal tumours.
  • METHODS: Immunohistological staining was performed with phosphorylated (p-) AKT, p-mTOR, p-4E-binding protein 1 (p-4EBP1), p-ribosomal protein S6 (p-S6), p-p70 ribosomal protein S6 kinase 1 (p-p70S6K1) and CDK2 in 15 cases each of seborrhoeic keratosis, actinic keratosis, keratoacanthoma and Bowen's disease (BD), and 25 cases of squamous cell carcinoma (SCC).
  • [MeSH-major] Bowen's Disease / metabolism. Carcinoma, Squamous Cell / metabolism. Cyclin-Dependent Kinase 2 / metabolism. Keratosis, Actinic / pathology. Sirolimus / pharmacology. Skin Neoplasms / metabolism


51. Rass K, Hamsch C: [Differential diagnosis of verrucous skin changes. When wild warts grow rapidly...]. MMW Fortschr Med; 2005 Sep 22;147(38):59-61
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  • [Title] [Differential diagnosis of verrucous skin changes. When wild warts grow rapidly...].
  • This article gives and overview of the various types of verrucous skin changes (viral warts, seborrheic warts).
  • [MeSH-major] Warts / diagnosis
  • [MeSH-minor] Adult. Age Factors. Aged. Carcinoma, Basal Cell / diagnosis. Child. Child, Preschool. Condylomata Acuminata / diagnosis. Condylomata Acuminata / epidemiology. Diagnosis, Differential. Female. Humans. Male. Melanoma / diagnosis. Molluscum Contagiosum / diagnosis. Molluscum Contagiosum / epidemiology. Risk Factors. Sex Factors. Skin Neoplasms / diagnosis

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  • (PMID = 16218230.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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52. Sharma P, Sarma DP, Adickes ED: Seborrheic keratosis with in-situ squamous cell carcinoma changes. Dermatol Online J; 2006;12(7):19
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  • [Title] Seborrheic keratosis with in-situ squamous cell carcinoma changes.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology


53. Martín JM, Monteagudo C, Calduch L, Villalón G, Jordá E: Dermatoscopic changes in acquired melanocytic nevi and seborrheic keratoses after the application of a self-tanning airbrush. Arch Dermatol; 2007 Nov;143(11):1453-5
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  • [Title] Dermatoscopic changes in acquired melanocytic nevi and seborrheic keratoses after the application of a self-tanning airbrush.
  • [MeSH-major] Coloring Agents / adverse effects. Dermoscopy. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis. Skin / drug effects. Skin Neoplasms / diagnosis

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  • (PMID = 18025381.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents
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54. Mabuchi T, Akasaka E, Kondoh A, Umezawa Y, Matsuyama T, Ozawa A: Seborrheic keratosis that follows Blaschko's lines. J Dermatol; 2008 May;35(5):301-3
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  • [Title] Seborrheic keratosis that follows Blaschko's lines.
  • A 66-year-old Japanese man had skin lesions on the left side of his trunk and the left upper extremity for approximately 10 years.
  • Clinical and histopathological findings led to a diagnosis of seborrheic keratosis that followed Blaschko's lines.
  • Our case supports the hypothesis that seborrheic keratosis can be associated with genetic mosaicism.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 18477232.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Segura S, Carrera C, Ferrando J, Mascaró JM Jr, Palou J, Malvehy J, Puig S: Dermoscopy in epidermodysplasia verruciformis. Dermatol Surg; 2006 Jan;32(1):103-6
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  • It clinically manifests as widespread, long-lasting, pityriasis versicolor-like macules and flat, wart-like papules, usually occurring in early childhood.
  • EV-associated human papillomaviruses have been implicated in a number of cutaneous lesions in non-EV populations, such as seborrheic keratoses or psoriasis.
  • RESULTS: Dermoscopy and histology of pityiriasis versicolor-like macules, wart-like papules, seborrheic keratosis-like tumors, psoriasis-like plaques, collision tumors, and Bowen in situ carcinoma are described.
  • CONCLUSIONS: Dermoscopy in EV tumors correlated with histopathologic findings and improved the differential diagnosis of tumors in this disease.
  • [MeSH-major] Bowen's Disease / pathology. Epidermodysplasia Verruciformis / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 16393609.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Lim C: Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol; 2006 May;47(2):109-13
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  • [Title] Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions.
  • Seborrhoeic keratoses are benign epidermal neoplasms that are rarely associated with other skin lesions especially malignancies.
  • In this study, the aim was to assess the incidence of associated lesions occurring either adjacent to or contiguous with a seborrhoeic keratosis.
  • In total, 639 consecutive histologically diagnosed seborrhoeic keratoses were identified, of which 85 (9%) were found to be associated with other lesions.
  • Of these associated lesions, 44 (7%) were malignant, with four of these found to be arising within the seborrhoeic keratosis.
  • The average age was 74 years (range 33-98 years).
  • Seborrhoeic keratoses associated with other lesions were found most commonly on the head and neck.
  • The incidence of associated lesions, in particular malignancy arising within seborrhoeic keratoses may be higher than previously thought.
  • This may be an incidental phenomenon, or seborrhoeic keratosis could represent a precursor lesion.
  • Therefore, seborrhoeic keratoses that have undergone recent clinical change should be considered for biopsy and histological examination.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Extremities. Head. Humans. Medical Records. Melanoma / epidemiology. Melanoma / etiology. Melanoma / pathology. Middle Aged. Neck. New South Wales / epidemiology. Precancerous Conditions. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637806.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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57. Repertinger S, Wang J, Adickes E, Sarma DP: Melanoma in-situ arising in seborrheic keratosis: a case report. Cases J; 2008;1(1):263
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  • [Title] Melanoma in-situ arising in seborrheic keratosis: a case report.
  • BACKGROUND: Seborrheic keratosis is a very common benign skin tumor in man.
  • A melanoma arising in a seborrheic keratosis is distinctly rare.
  • We are reporting such a case occurring in an 86-year-old man.
  • CASE PRESENTATION: An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion.
  • The biopsied lesion was composed of the usual features of hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferation with nesting along the dermal-epidermal junction.
  • We interpreted this lesion as a melanoma in-situ arising within a seborrheic keratosis.
  • CONCLUSION: It is not uncommon for many physicians to remove a typical seborrheic keratosis without a confirmatory microscopic confirmation.

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  • [Cites] Australas J Dermatol. 2006 May;47(2):109-13 [16637806.001]
  • [Cites] J Am Acad Dermatol. 2000 May;42(5 Pt 1):831-3 [10775864.001]
  • [Cites] Dermatol Surg. 2004 Apr;30(4 Pt 1):559-61 [15056152.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 18947402.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2577645
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58. Madan V, Cox NH, Gangopadhayay M: Porocarcinoma arising in a broad clonal seborrhoeic keratosis. Clin Exp Dermatol; 2008 May;33(3):350-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Porocarcinoma arising in a broad clonal seborrhoeic keratosis.
  • [MeSH-major] Bowen's Disease / pathology. Eccrine Glands / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2009 Oct;34(7):e371-2 [19486048.001]
  • [CommentOn] Clin Exp Dermatol. 2007 Jan;32(1):54-6 [17004985.001]
  • (PMID = 18261140.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
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59. Livaoglu M, Karacal N, Gücer H, Arvas L: Giant genital seborrheic keratosis. Dermatol Surg; 2007 Nov;33(11):1357-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant genital seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Genital Diseases, Male / diagnosis. Humans. Male

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  • [CommentIn] Dermatol Surg. 2008 Nov;34(11):1615 [18823349.001]
  • (PMID = 17958589.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Hultgren TL, Srinivasan SK, DiMaio DJ: Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus: a case report. Cutis; 2007 Apr;79(4):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Epidermodysplasia verruciformis (EV) is an uncommon dermatosis associated with human papillomavirus (HPV) infection in association with defects in cell-mediated immunity.
  • Malignant transformation to squamous cell carcinoma has been associated with lesions caused by HPV-5, HPV-8, and HPV-14.
  • Clinically, the disease may be confused with verruca plana, seborrheic keratosis, and pityriasis versicolor.
  • Although EV typically is viewed as a disease of childhood, sometimes presenting in patients with a family history of the disease, it rarely may be seen in immunocompromised adults.

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  • (PMID = 17500379.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Park JM, Tsao H, Tsao S: Combined use of intense pulsed light and Q-switched ruby laser for complex dyspigmentation among Asian patients. Lasers Surg Med; 2008 Feb;40(2):128-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Many individuals exhibit mixed pigmentary entities including melasma, flat/small seborrheic keratoses, ephelides, solar lentigines and acquired bilateral nevus-of-Ota-like macules (ABNOM).

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  • (PMID = 18306166.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Tan E, Oakley A, Soyer HP, Haskett M, Marghoob A, Jameson M, Rademaker M: Interobserver variability of teledermoscopy: an international study. Br J Dermatol; 2010 Dec;163(6):1276-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Teledermoscopy is a rapidly developing field of dermatology with studies demonstrating excellent agreement with face-to-face diagnosis.
  • However, we are unaware of studies evaluating interobserver variability in diagnosis between dermatologists from different continents.
  • RESULTS: There was excellent agreement between four of five dermatologists (A-D) for lesions that were agreed upon as melanoma (κ = 0·81-0·97) and benign naevus (κ = 0·77-0·82).The fifth dermatologist (E) made a more frequent diagnosis of atypical naevus and melanoma than the others.
  • For nonmelanocytic lesions, there was moderate to very good agreement for seborrhoeic keratosis (κ = 0·64-0·80) and basal cell carcinoma (κ = 0·55-0·67), but poor agreement for invasive squamous cell carcinoma (SCC) (κ = 0·05-0·15).
  • Agreement for actinic keratosis (κ = 0·32-0·67) and SCC in situ (κ = 0·15-0·32) was only moderate.
  • When atypical and benign naevi were grouped together and actinic keratosis and SCC in situ grouped together, there was better agreement among all dermatologists.
  • CONCLUSIONS: There was good agreement among dermatologists A-D but dermatologist E varied from the group with more frequent diagnosis of melanoma and atypical naevus.
  • [MeSH-major] Dermoscopy / methods. Remote Consultation / standards. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20795998.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Porta N, San Juan J, Grasa MP, Simal E, Ara M, Querol MA: [Diagnostic agreement between primary care physicians and dermatologists in the health area of a referral hospital]. Actas Dermosifiliogr; 2008 Apr;99(3):207-12
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  • [Transliterated title] Estudio de concordancia diagnóstica en Dermatología entre Atención Primaria y Especializada en el área de salud de un hospital de referencia.
  • This study aimed to investigate the characteristics of referrals from primary care centers to dermatology specialists as well as the correlation between the presenting complaint and the final dermatologic diagnosis.
  • The agreement between the presenting complaint and the final dermatologic diagnosis was studied.
  • Primary care physicians were found to over diagnose diseases caused by papillomavirus and the diagnostic sensitivity was very low for diseases such as basal cell carcinoma and seborrheic keratosis.
  • [MeSH-major] Dermatology. Primary Health Care. Skin Diseases / diagnosis

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  • (PMID = 18358196.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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64. Monteagudo B, Alvarez-Alvarez C, López-Mouriño VM: [Eruptive seborrheic keratoses triggered by eczema]. Actas Dermosifiliogr; 2005 Mar;96(2):130
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  • [Title] [Eruptive seborrheic keratoses triggered by eczema].
  • [Transliterated title] Queratosis seborreicas eruptivas desencadenadas por un eczema.
  • [MeSH-major] Acanthoma / complications. Eczema / complications. Keratosis, Seborrheic / etiology. Skin Neoplasms / complications

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  • (PMID = 16476353.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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65. Goetze S, Ziemer M, Kaatz M, Lipman RD, Elsner P: Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study. Dermatol Surg; 2006 May;32(5):661-8
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  • [Title] Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study.
  • OBJECTIVE: To evaluate the wound-healing activity of a commercially available hydrocolloid wound dressing (Avery H2460, Avery Dennison, Turnhout, Belgium) in comparison with a control treatment (Fucidine cream with Cutiplast sterile dressing) in superficial wounds after surgical removal of seborrheic keratoses.
  • Sixteen patients between 18 and 80 years of age with seborrheic keratoses were enrolled.
  • [MeSH-major] Bandages, Hydrocolloid. Keratosis, Seborrheic / surgery

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  • (PMID = 16706761.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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66. Hoshina D, Akiyama M, Hata H, Aoyagi S, Sato-Matsumura KC, Shimizu H: Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2007 Jan;32(1):54-6
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  • [Title] Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis.
  • An association between seborrhoeic keratosis (SK) and malignant tumours is considered to be rare.
  • We observed a case of eccrine porocarcinoma and Bowen's disease (BD) occurring synchronously, forming one lesion in a SK on the abdomen.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma / pathology. Eccrine Glands. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 17004985.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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67. Brodsky J: Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea. Curr Opin Otolaryngol Head Neck Surg; 2009 Aug;17(4):315-20
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  • [Title] Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea.
  • RECENT FINDINGS: Actinic keratosis can now be treated with photodynamic therapy or with many topical agents, as alternatives to traditional surgical techniques.
  • Seborrheic keratosis, as well as actinic keratosis and rosacea, are now often treated with laser therapy.
  • [MeSH-major] Facial Dermatoses / therapy. Keratosis, Actinic / therapy. Keratosis, Seborrheic / therapy. Rosacea / therapy


68. Noiles K, Vender R: Are all seborrheic keratoses benign? Review of the typical lesion and its variants. J Cutan Med Surg; 2008 Sep-Oct;12(5):203-10
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  • [Title] Are all seborrheic keratoses benign? Review of the typical lesion and its variants.
  • BACKGROUND: Seborrheic keratosis (SK) is one of the more common benign epidermal neoplasms seen in adult and middle-aged patients.
  • RESULTS: Six subtypes of SK were identified: dermatosis papulosa nigra, stucco keratosis, inverted follicular keratosis, large cell acanthoma, lichenoid keratosis, and flat seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / classification. Skin Neoplasms / classification

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  • (PMID = 18845088.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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69. Hinckley M, Feldman SR, Fleischer AB, Vallejos QM, Whalley LE, Quandt SA, Heck J, Cabral G, Brooks T, Schulz MR, Arcury TA: Common skin disorders seen in the migrant farmworker health care clinic setting. J Agromedicine; 2007;12(4):71-9
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  • Migrant farmworkers commonly access rural health clinics for diagnosis and treatment of skin disease.
  • The most common conditions were contact dermatitis, melasma, tinea, seborrheic keratoses, and impetigo.

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  • (PMID = 19042681.001).
  • [ISSN] 1059-924X
  • [Journal-full-title] Journal of agromedicine
  • [ISO-abbreviation] J Agromedicine
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / R01-ES012358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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70. Tsai TM, Wu YH, Yang KC, Yang CY, Tsai TH, Chan JY: Sebaceous carcinoma associated with seborrheic keratosis. J Cutan Med Surg; 2010 Sep-Oct;14(5):240-4
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  • [Title] Sebaceous carcinoma associated with seborrheic keratosis.
  • BACKGROUND: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual.
  • OBJECTIVE: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings.
  • METHODS AND RESULTS: A 57-year-old man presented with an asymptomatic tumor on the skin of his abdomen that was composed of two separate but contiguous lesions.
  • Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis.
  • CONCLUSION: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20868621.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Garcia MS, Azari R, Eisen DB: Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. Dermatol Surg; 2010 Dec;36(12):1968-72
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  • BACKGROUND: Dermatosis papulosa nigra (DPN) is a common variant of seborrheic keratoses in darkly pigmented individuals.

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  • [Copyright] © 2010 by the American Society for Dermatologic Surgery, Inc.
  • (PMID = 21040130.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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72. Lipozenčić J, Bukvić Mokos Z: Dermatologic lasers in the treatment of aging skin. Acta Dermatovenerol Croat; 2010;18(3):176-80
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  • The major clinical features of aging skin include xerosis, laxity, wrinkles, slackness, and the occurrence of benign neoplasms such as seborrheic keratoses and cherry angiomas.
  • Photoaging is characterized by dryness (roughness), actinic keratoses, irregular pigmentation (freckling, lentigines, guttate hypomelanosis, persistent hyperpigmentation), wrinkling, stellate pseudoscars, elastosis (fine nodularity and/or coarseness), inelasticity, telangiectasia, venous lakes, purpura (easy bruising), comedones (maladie de Favre et Racouchot) and sebaceous hyperplasia.
  • In this manuscript laser resurfacing and laser therapy of vascular and pigmented lesions of aging skin will be overviewed.

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  • (PMID = 20887699.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
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73. Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA: Nonmelanocytic lesions defying the two-step dermoscopy algorithm. Dermatol Surg; 2006 Nov;32(11):1398-406
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  • The first step of the two-step algorithm of dermoscopy aims at differentiating melanocytic from nonmelanocytic pigmented lesions, using a stepwise evaluation for the presence of specific dermoscopic criteria.
  • Seborrheic keratosis, solar lentigo, dermatofibroma, and supernumerary accessory nipple may present with network-like structures.
  • Seborrheic keratosis, dermatofibroma, subcorneal hemorrhage, basal cell carcinoma (BCC), and cutaneous metastases of breast and other cancers may contain pigmented globules.
  • Peripheral streaks can also be seen in seborrheic keratosis and BCC.
  • This overlap of features between melanocytic and nonmelanocytic lesions suggests that integration of all dermoscopic features in the lesion, rather than a stepwise evaluation, may facilitate reaching the correct diagnosis in select cases as outlined in this article.
  • [MeSH-major] Algorithms. Dermoscopy / methods. Melanoma, Amelanotic / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17083595.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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74. Laing ME, O'Keane C, Murphy GM: Basal cell carcinoma arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2009 Oct;34(7):e371-2
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  • [Title] Basal cell carcinoma arising in a seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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  • [CommentOn] Clin Exp Dermatol. 2008 Jul;33(4):512-3 [18462448.001]
  • [CommentOn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 19486048.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
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75. Culbertson GR: 532-nm diode laser treatment of seborrheic keratoses with color enhancement. Dermatol Surg; 2008 Apr;34(4):525-8; discussion 528
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  • [Title] 532-nm diode laser treatment of seborrheic keratoses with color enhancement.
  • BACKGROUND: Seborrheic keratoses (SKs) are benign cutaneous tumors of the epidermis.
  • Hypopigmentation occurred in 6% of patients and was associated with old, chronic, or recalcitrant lesions.
  • [MeSH-major] Color Therapy. Keratosis, Seborrheic / therapy. Laser Therapy / methods. Lasers, Semiconductor

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  • (PMID = 18248487.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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76. Terada T: Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. Int J Clin Oncol; 2010 Dec;15(6):608-10
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  • [Title] Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis.
  • A 76-year-old man consulted to our hospital complaining of a black tumor of the temporal head.
  • A clinical diagnosis of basal cell carcinoma was made, and an excision with wide margins was performed.
  • The cells were heavily pigmented.
  • The periphery of the tumor showed typical features of pigmented reticulated seborrheic keratosis.
  • This case suggests that pigmented Bowen disease can arise in pigmented reticulated seborrheic keratosis.
  • [MeSH-major] Bowen's Disease / etiology. Carcinoma, Basal Cell / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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  • [Cites] J Dermatol Surg Oncol. 1988 Jul;14(7):765-9 [3292613.001]
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  • (PMID = 20425131.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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77. Chen QP, Aw DC: Epidemiology of skin diseases in renal transplant recipients in a tertiary hospital. Ann Acad Med Singapore; 2010 Dec;39(12):904-5
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  • RESULTS: Our study showed that except the common drug specific skin manifestations, sebaceous hyperplasia (56.6%), seborrheic keratosis (60.8%), melanocytic naevi (76.9%), skin tags (37.1%) and viral (29.4%) and fungal (20.3%) infections were the most prevalent skin diseases among renal transplant recipients living in Singapore.
  • The prevalence of pre-malignant and malignant tumours was very low (11.2% actinic keratosis, 1.4% Bowen's disease, 1.4% squamous cell carcinoma, 0.7% basal cell carcinoma, 0.7% keratoacanthoma).
  • Male predominance was seen in sebaceous hyperplasia (72.4% vs 32.1%), actinic keratosis (17.2% vs 1.8%), viral (36.8% vs 19.6%) and fungal (27.6% vs 8.9%) infections.
  • Our study also showed increased prevalence of sebaceous hyperplasia with increased age but its prevalence was significantly higher than that reported in the age matched general population.
  • The prevalence of seborrheic keratosis, actinic keratosis and viral infection correlated positively with post-transplant duration.
  • It emphasises the importance of dermatologic follow-up for renal transplant patients in order to obtain a diagnosis and manage treatable skin diseases.

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  • (PMID = 21274486.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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78. Fernandez MP, Wang NS, Terzakis JA, Meehan SA, Kamino H: Histopathology and X-ray microanalysis of foreign material on facial keratoses. Am J Dermatopathol; 2009 May;31(3):232-5
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  • [Title] Histopathology and X-ray microanalysis of foreign material on facial keratoses.
  • Opaque exogenous material was frequently observed on the surface of keratoses during routine sign out by one of us (H.K.).
  • To investigate this material further, 300 consecutive seborrheic keratoses were reviewed: 100 cases from the face of women, 100 cases from the face of men, and 100 cases from the trunk of men and women.
  • The material was present on 54% of facial keratoses from predominantly older women (mean age 67 years), 5% of facial keratoses from men, and 9% of truncal keratoses from men and women.
  • Further, because the exogenous material was found predominantly on facial keratoses of older women, the presence of this material in a specimen may serve as a clue to the patient's gender, age, and biopsy site.
  • [MeSH-major] Electron Probe Microanalysis. Facial Dermatoses / pathology. Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 19384063.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Ointments
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79. Sawada Y, Yoshiki R, Kawakami C, Nakamura M, Tokura Y: [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature]. J UOEH; 2009 Mar 1;31(1):51-5
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  • [Title] [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature].
  • A 78-year-old man was seen for a tumor on his umbilicus.
  • The excised tumor showed the acanthotic type of seborrheic keratosis.
  • Six cases of seborrheic keratosis arising on the umbilicus have been reported.
  • Our case is the first report of an acanthotic type of seborrheic keratosis on the umbilicus.
  • Seborrheic keratosis is one of the common skin tumors, but we hesitated in this diagnosis because of its abnormal location.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Umbilicus

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  • (PMID = 19297955.001).
  • [ISSN] 0387-821X
  • [Journal-full-title] Journal of UOEH
  • [ISO-abbreviation] J. UOEH
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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80. Carli P, De Giorgi V, Crocetti E, Caldini L, Ressel C, Giannotti B: Diagnostic and referral accuracy of family doctors in melanoma screening: effect of a short formal training. Eur J Cancer Prev; 2005 Feb;14(1):51-5
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  • Little is known about ability of family doctors in the diagnosis and management (decision as to dermatologic referral) of pigmented skin lesions.
  • Before and after the course, a diagnostic test with a series of clinical images of pigmented skin lesions including four invasive melanomas (mean thickness, 1.5 mm; range, 0.8-2.2) was performed (open intervention study).
  • Although only 46.8% of observations yielded a correct melanoma diagnosis at baseline, 96.1% of melanoma observations were correctly associated with intention to refer the lesion to dermatologist.
  • After training, the percentage of correct melanoma diagnosis significantly increased (76.2%, P=0.01) while no further improvement was found as to sensitivity of referral (94.8%, P=0.58).
  • Compared to baseline, post-training evaluation showed a significant reduction of benign lesions sent to dermatologist: the percentage lowered from 52.1 to 35.8% (P=0.0014) for melanocytic nevi and from 38.6 to 17.5% (P<0.001) for benign non-melanocytic lesions (pigmented seborrheic keratoses, dermatofibromas, and vascular lesions).
  • [MeSH-major] Family Practice. Mass Screening / standards. Melanoma / diagnosis. Referral and Consultation. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Dermatology. Diagnosis, Differential. Education, Medical, Continuing. False Positive Reactions. Humans. Reproducibility of Results


81. Vun Y, De'Ambrosis B, Spelman L, Muir JB, Yong-Gee S, Wagner G, Lun K: Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation? Australas J Dermatol; 2006 May;47(2):106-8
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  • [Title] Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation?
  • A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer.
  • Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36).
  • There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas.
  • Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas.
  • Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis.
  • These lesions may represent malignant transformation within the seborrhoeic keratosis.
  • Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses.
  • Clinically, the remaining two were seborrhoeic keratoses.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Female. Head. Humans. Male. Medical Records. Middle Aged. Precancerous Conditions. Queensland / epidemiology. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637805.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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82. McNicholas M: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977070.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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83. Fontaine J, Dalle S, Thomas L: [Seborrheic keratosis]. Ann Dermatol Venereol; 2008 Aug-Sep;135(8-9):618-9
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  • [Title] [Seborrheic keratosis].
  • [MeSH-major] Keratosis, Seborrheic
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Female. Humans. Middle Aged. Skin / pathology

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  • (PMID = 18789303.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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84. Coroi MC, Roşca E, Muţiu G, Coroi T, Bonta M: Eyelid tumors: histopathological and clinical study performed in County Hospital of Oradea between 2000-2007. Rom J Morphol Embryol; 2010;51(1):111-5
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  • The most affected age range was the sixth decade and the majority of tumors were located to lower eyelid.
  • The Meibomian gland cysts, squamous papillomas and basal cell carcinomas were the most frequent related with this three of category lesions represented by pseudotumors, benign tumors and malignant tumors.
  • Early diagnosis of these lesions can determine a favorable prognosis, especially in cases of malignant tumors.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Chalazion / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 20191129.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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85. Kessler GM, Ackerman AB: Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective. Am J Dermatopathol; 2006 Dec;28(6):537-45
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  • [Title] Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective.
  • Squamous-cell carcinoma is the most common of all cancers and it develops in diverse organs of the body, among those being the skin, lung, gastrointestinal tract, and genitourinary tract, the latter including the cervix.
  • Unfortunately, no unanimity exists for naming very superficial squamous-cell carcinoma; it has not been designated in consistent fashion in a single organ, let alone in all of them, thereby resulting in confusion, not only in regard to terminology per se, but concerning matters conceptual, not the least of those being what appellation to apply to that condition when it is encountered histopathologically.
  • This vexing situation is illustrated graphically in the skin by diagnoses for very superficial squamous-cell carcinoma as disparate as solar keratosis (actinic keratosis, senile keratosis), arsenical keratosis, radiation keratosis, Bowen disease, bowenoid papulosis, squamous-cell carcinoma in situ, as well as variations on the theme of "keratinocytic intraepidermal neoplasia" and "dysplasia," and in the cervix by squamous-cell carcinoma in situ, leukoplakia, cervical intraepithelial neoplasia I-III, as well as variations on the theme of "squamous dysplasia ()."
  • There is a need urgently for a single term for very superficial squamous-cell carcinoma in every organ of the body in which it develops, to wit, one that conveys diagnosis in such logical, lucid, comprehensible fashion that it is understandable, readily and immediately, to clinicians.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Skin Neoplasms / classification. Uterine Cervical Neoplasms / classification


86. Baumann L, Vujevich J, Halem M, Martin LK, Kerdel F, Lazarus M, Pacheco H, Black L, Bryde J: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging. Cutis; 2005 Jul;76(1):69-73
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  • The treatment was well tolerated by participants (N=20) and subjectively showed improvement of benign skin lesions (eg, seborrheic keratoses) and precancerous lesions (eg, actinic keratoses).

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  • (PMID = 16144296.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gels; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin
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87. Ko CJ, Subtil A: Clear (pale) cell acanthosis as an incidental finding. J Cutan Pathol; 2009 May;36(5):573-7
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  • [Title] Clear (pale) cell acanthosis as an incidental finding.
  • Different patterns of epidermal change, including epidermolytic hyperkeratosis and acantholytic dyskeratosis, may represent the predominant histopathologic finding in several localized and generalized processes.
  • Occasionally, minute foci of these reaction patterns are identified as an incidental finding in a biopsy taken because of the presence of some other lesion.
  • Clear (pale) cell acanthosis may occur as the main histologic alteration in clear (pale) cell acanthoma or incidentally, such as may be seen within a seborrheic keratosis.
  • Two cases of incidental minute foci of clear (pale) cell acanthosis are described and put into the broader context of other epidermal histologic reaction patterns.
  • [MeSH-minor] Female. Humans. Incidental Findings. Keratosis, Seborrheic / complications. Keratosis, Seborrheic / pathology. Male. Melanoma / complications. Middle Aged. Nevus, Pigmented / complications. Skin Neoplasms / complications

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  • (PMID = 19476527.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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88. Thakur JS, Thakur A, Chauhan CG, Diwana VK, Chauhan DC: Giant pedunculated seborrheic keratosis of penis. Indian J Dermatol; 2008 Jan;53(1):37-8
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  • [Title] Giant pedunculated seborrheic keratosis of penis.
  • Seborrheic keratosis of the penis is a rare entity.
  • It has been mistaken as genital warts and differentiation is only made on histopathology.
  • Seborrheic keratosis should be considered in the differential diagnosis of pedunculated lesions of the penis.

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  • [Cites] Am J Dermatopathol. 1994 Aug;16(4):398-405; discussion 406-8 [7978069.001]
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  • (PMID = 19967020.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2784587
  • [Keywords] NOTNLM ; Penis / seborrheic keratosis / warts
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89. Virgili A, Zampino MR, Marzola A, Corazza M: Vulvar melanocytic nevi: a dermoscopic investigation. Dermatology; 2010 Aug;221(1):55-62
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  • BACKGROUND: Very few dermoscopic investigations into pigmented genital lesions have been performed to date.
  • METHODS: Among 74 women presenting 84 vulvar pigmented lesions, 10 who received a visual diagnosis of MN were submitted to dermoscopic and histopathological analysis.
  • RESULTS: Histology confirmed the clinical diagnosis of MN in 8 out of 10 cases, while the remaining 2 pigmented lesions were diagnosed as seborrheic keratosis.
  • CONCLUSIONS: Although further observation will be necessary to provide additional data and establish key morphological criteria and/or algorithms useful for differentiating between melanocytic and nonmelanocytic vulvar lesions, dermoscopy should be considered an investigative tool, as clinical observation alone may not be sufficient for accurate diagnosis.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Young Adult

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20484874.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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90. Siedek V, Schuh T, Wollenberg A: Leser-Trelat sign in metastasized malignant melanoma. Eur Arch Otorhinolaryngol; 2009 Feb;266(2):297-9
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  • The Leser-Trelat sign is defined as the association of multiple, eruptive seborrheic keratoses with an internal malignancy of a usually advanced stage.
  • We report the case of malignant melanoma in an 82-year-old man covered with hundreds of greyish-dark seborrheic keratoses resembling a Christmas tree pattern, who was diagnosed with metastasized malignant melanoma involving the parotid gland and lymph nodes.
  • Though the pathogenesis of Leser-Trelat sign is still unknown, spontaneous regression of the seborrheic keratoses following tumor reduction described in some cases argues for a paraneoplastic origin of this highly instructive clinical entity.
  • Physicians should consider a workup for internal malignancy in patients presenting with multiple eruptive seborrheic keratoses.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Melanoma / secondary. Paraneoplastic Syndromes / pathology. Skin Neoplasms / pathology

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  • (PMID = 18369652.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 7GR28W0FJI / Dacarbazine
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91. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • [Title] Pityrosporum and seborrheic keratosis: an association.
  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, however, its potential role in association with SK's has not been evaluated as evidenced by the fact that there are no publications in the English-language literature regarding this issue.
  • We found that in a majority of the SK studied Pityrosporum was present, which was significantly different from controls (verruca vulgaris and basal cell carcinoma).
  • [MeSH-major] Dermatomycoses / complications. Keratosis, Seborrheic / etiology. Keratosis, Seborrheic / microbiology. Malassezia / isolation & purification

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Sun J, Gui X, He J, Liu HM, Yu HY, Xia CY, Xu Y: [The relationship between infestation of Demodex folliculorum and epidermal neoplasm on face]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2005 Dec 30;23(6):428-31
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  • METHODS: A retrospective analysis was made with the pathological data of 153 cases collected in the recent four years on facial basal cell carcinoma, squamous cell carcinoma, seborrheic keratosis and trichilemmoma.
  • The infection rate of Demodex folliculorum in the four types of neoplasm was evaluated and the relationship between the infection rate and the location of neoplasm and age was analyzed by V2 test.
  • RESULTS: There was a significant difference in the infestation rate of Demodex folliculorum in the four types of epidermal neoplasm(P < 0.05), with the highest rate in basal cell carcinoma(56%), compared with seborrheic keratosis (21%), trichilemmoma (20%), and squamous cell carcinoma (14%).
  • In addition, among twelve cases of Demodex folliculorum positive nasal neoplasm, nine were basal cell carcinoma; ten of thirty-six basal cell carcinoma occurred on nose.
  • CONCLUSION: The highest infestation rate of Demodex folliculorum was in cases of nasal epidermal neoplasm compared with other locations, and the cases of basal cell carcinoma showed the highest infestation rate among the four types of neoplasm.

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  • (PMID = 16566213.001).
  • [ISSN] 1000-7423
  • [Journal-full-title] Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
  • [ISO-abbreviation] Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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93. Hafner C, Stoehr R, van Oers JM, Zwarthoff EC, Hofstaedter F, Landthaler M, Hartmann A, Vogt T: FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo. Br J Dermatol; 2009 Mar;160(3):546-51
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  • It has been proposed that SL may subsequently evolve into adenoid seborrhoeic keratosis (SK).

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  • (PMID = 19076977.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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94. Thyssen JP, Zachariae C: Successful treatment of multiple seborrheic keratoses using acitretin. J Eur Acad Dermatol Venereol; 2007 Feb;21(2):269-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of multiple seborrheic keratoses using acitretin.
  • [MeSH-major] Acitretin / therapeutic use. Keratolytic Agents / therapeutic use. Keratosis, Seborrheic / drug therapy

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  • (PMID = 17243977.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratolytic Agents; LCH760E9T7 / Acitretin
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95. Kocyigit P, Akay BN, Arica E, Anadolu RY, Erdem C: Post-renal transplantation Leser-Trélat sign associated with carcinoma of the gallbladder: a rare association. Scand J Gastroenterol; 2007 Jun;42(6):779-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The sign of Leser-Trélat represents the sudden appearance of multiple seborrheic keratoses in association with an underlying malignancy.
  • Here, we report on a 57-year-old man who presented with a sudden increase in the number and size of seborrheic keratoses, particularly on sun-exposed areas 24 years after renal transplantation.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Keratosis, Seborrheic / pathology. Kidney Transplantation


96. Shamsadini S, Wadji MB, Shamsadini A: Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign). Dermatol Online J; 2006;12(6):27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign).
  • Paget disease of the breast, most often occurs in middle-aged women.
  • We report a patient with Paget disease of the nipple and intraductal carcinoma who presented with ipsilateral, eruptive grouped seborrheic keratoses of the areola and nipple of the breast.
  • [MeSH-major] Breast Diseases / etiology. Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Keratosis, Seborrheic / etiology. Paget's Disease, Mammary / diagnosis. Paraneoplastic Syndromes / etiology


97. White E: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977069.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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98. Suiqing C, Min Z, Lirong C: Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol; 2005 May;32(5):354-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma.
  • In order to evaluate the possible effects of STAT3 phosphorylation and expression of E-cadherin on metastasis of some human epidermal non-melanoma cutaneous tumors, the expression of phosphorylated STAT3 (p-STAT3) and E-cadherin were analyzed by immunohistochemistry staining in formalin-fixed, paraffin-embedded tissue sections of human cutaneous squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and seborrhoeic keratosis (SK).
  • 3) E-cadherin was strongly expressed on the cell membranes of normal skin and SK, especially on basal cells.
  • E-cadherin was weakly expressed on cell membranes of SCC and BCC (p<0.001), whereas its expression was significantly lower in SCC than in BCC (p<0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Neoplasm Invasiveness / physiopathology. Skin Neoplasms / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy, Needle. Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / secondary. Case-Control Studies. Female. Humans. Immunohistochemistry. Keratosis, Seborrheic / metabolism. Keratosis, Seborrheic / pathology. Male. Probability. Prognosis. Reference Values. STAT3 Transcription Factor. Sensitivity and Specificity. Tissue Culture Techniques


99. Ko CJ, Iftner T, Barr RJ, Binder SW: Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. J Cutan Pathol; 2007 Jan;34(1):44-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These skin lesions included an intradermal nevus, a pigmented seborrheic keratosis, an isolated papule on the forearm, a perianal lesion, and an acantholytic acanthoma.
  • Because the changes resembled true EV so strongly despite the absence of clinical EV in these patients, we searched for EV-human papilloma virus (HPV) types in these skin lesions.
  • EV changes and EV-HPV can be found incidentally on biopsy in the absence of clinical EV; when such changes are the major histopathological finding in an isolated skin lesion, the lesion should be termed an EV acanthoma.
  • [MeSH-minor] Adult. Aged. Female. Humans. Keratosis, Seborrheic / pathology. Keratosis, Seborrheic / virology. Male. Middle Aged. Nevus / pathology. Nevus / virology. Papillomaviridae / classification. Papillomaviridae / isolation & purification


100. Niang SO, Kane A, Diallo M, Choutah F, Dieng MT, Ndiaye B: Dermatosis papulosa nigra in Dakar, Senegal. Int J Dermatol; 2007 Oct;46 Suppl 1:45-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a special topographic form of ethnic seborrheic keratosis, which is more common in the white population.
  • The diagnosis of DPN was clinical.
  • The average age was 39.8 years (range, 25-70 years).
  • The average age of onset of the lesions was 22 years, with a progressive increase in size and number.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology. Skin Neoplasms / epidemiology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • (PMID = 17919208.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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