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1. Desjardins L: [Benign pigmented lesions of the eyelids]. J Fr Ophtalmol; 2005 Oct;28(8):889-95
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  • [Title] [Benign pigmented lesions of the eyelids].
  • We describe benign pigmented tumors of the lids, including benign lesions of the epithelium such as papillomas, seborrheic keratosis, and inverted follicular keratosis; precancerous lesions of the epithelium such as xeroderma pigmentosum and actinic keratosis; melanocytic lesions such as Ota nevus, lentigo, and lentigo maligna; and nevi and other lesions simulating a melanoma such as pigmented hidrocystoma, angiomas, and epithelial cyst.

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  • (PMID = 16249773.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 34
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2. Fernandez-Flores A: Irritated seborrheic keratosis with coarse keratohyalin granules. Rom J Morphol Embryol; 2009;50(4):583-7
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  • [Title] Irritated seborrheic keratosis with coarse keratohyalin granules.
  • AIMS: The viral etiology of certain types of seborrheic keratosis (SK) has been a controversial subject in literature, with different molecular results.
  • On the contrary, to the molecular approach, some have suggested that certain types of SK are indeed warts, due to their morphologic features.
  • MATERIAL, METHODS AND RESULTS: We examined the last 60 cases with such a diagnosis in our Service of Anatomic Pathology and found these granules in eight cases (7.5%).
  • In these eight cases, we also looked for other morphologic signs suggesting a viral origin, such as papilated, exo-endophytic configuration, parakeratosis at the tips of digitations, dilated vessels in the papillae and koilocytes.
  • CONCLUSIONS: We discuss the meaning of such a finding as described in literature, and conclude that it should be a specific feature to look out for, in cases of irritated SK, in order to exclude a diagnosis of verruca vulgaris.
  • [MeSH-major] Cytoplasmic Granules / pathology. Keratins / metabolism. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Epidermis / metabolism. Epidermis / pathology. Epidermis / virology. Female. Humans. Male. Middle Aged. Parakeratosis / metabolism. Parakeratosis / pathology. Parakeratosis / virology. Warts / pathology. Warts / virology

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  • (PMID = 19942951.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / keratohyalin; 68238-35-7 / Keratins
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3. Repertinger S, Wang J, Adickes E, Sarma DP: Melanoma in-situ arising in seborrheic keratosis: a case report. Cases J; 2008;1(1):263
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  • [Title] Melanoma in-situ arising in seborrheic keratosis: a case report.
  • BACKGROUND: Seborrheic keratosis is a very common benign skin tumor in man.
  • A melanoma arising in a seborrheic keratosis is distinctly rare.
  • We are reporting such a case occurring in an 86-year-old man.
  • CASE PRESENTATION: An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion.
  • The biopsied lesion was composed of the usual features of hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferation with nesting along the dermal-epidermal junction.
  • We interpreted this lesion as a melanoma in-situ arising within a seborrheic keratosis.
  • CONCLUSION: It is not uncommon for many physicians to remove a typical seborrheic keratosis without a confirmatory microscopic confirmation.

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  • [Cites] Australas J Dermatol. 2006 May;47(2):109-13 [16637806.001]
  • [Cites] J Am Acad Dermatol. 2000 May;42(5 Pt 1):831-3 [10775864.001]
  • [Cites] Dermatol Surg. 2004 Apr;30(4 Pt 1):559-61 [15056152.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 18947402.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2577645
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4. Thakur JS, Thakur A, Chauhan CG, Diwana VK, Chauhan DC: Giant pedunculated seborrheic keratosis of penis. Indian J Dermatol; 2008 Jan;53(1):37-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant pedunculated seborrheic keratosis of penis.
  • Seborrheic keratosis of the penis is a rare entity.
  • It has been mistaken as genital warts and differentiation is only made on histopathology.
  • Seborrheic keratosis should be considered in the differential diagnosis of pedunculated lesions of the penis.

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  • [Cites] Am J Dermatopathol. 1994 Aug;16(4):398-405; discussion 406-8 [7978069.001]
  • [Cites] Am J Dermatopathol. 1993 Feb;15(1):1-6 [8382012.001]
  • [Cites] Urology. 1974 May;3(5):595-7 [4275401.001]
  • [Cites] Am J Dermatopathol. 1989 Jun;11(3):209-12 [2543229.001]
  • [Cites] Am Fam Physician. 1986 Aug;34(2):147-52 [2944363.001]
  • [Cites] Urology. 1987 Feb;29(2):204-6 [2949418.001]
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  • (PMID = 19967020.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2784587
  • [Keywords] NOTNLM ; Penis / seborrheic keratosis / warts
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5. Kim JH, Bae HW, Lee KK, Kim TI, Kim EK: Seborrheic keratosis of the conjunctiva: a case report. Korean J Ophthalmol; 2009 Dec;23(4):306-8
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  • [Title] Seborrheic keratosis of the conjunctiva: a case report.
  • Seborrheic keratosis is a benign epithelial neoplasia that occurs mainly in the skin of the eyelids and face.
  • We describe a case of seborrheic keratosis of the conjunctiva confirmed by histopathology.
  • A 72-year-old man presented with a recurrent conjunctival mass involving the nasal side of his right eye.
  • Clinically, a diagnosis of conjunctival papilloma was made, and a mass excision was performed.
  • With the above findings, a diagnosis of conjunctival seborrheic keratosis was established.
  • The occurrence of seborrheic keratosis on the conjunctiva is rare.
  • In this case, seborrheic keratosis was confirmed by pathologic report despite its similar appearance with papilloma.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival lesions.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Microscopy, Acoustic. Ophthalmologic Surgical Procedures / methods

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  • [Cites] Indian J Ophthalmol. 2004 Jun;52(2):154-5 [15283223.001]
  • [Cites] Br J Ophthalmol. 1994 Apr;78(4):252-9 [8199108.001]
  • [Cites] Arch Dermatol Res. 1995;287(6):612-5 [7487151.001]
  • [Cites] Arch Soc Esp Oftalmol. 2006 Apr;81(4):217-9 [16688646.001]
  • [Cites] Surv Ophthalmol. 1998 Jan-Feb;42(4):321-50 [9493274.001]
  • [Cites] Ophthalmology. 1999 Aug;106(8):1516-20 [10442897.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 20046694.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2789958
  • [Keywords] NOTNLM ; Conjunctival mass / Papilloma / Seborrheic keratosis
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6. Hafner C, Hartmann A, Vogt T: FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin. J Invest Dermatol; 2007 Jul;127(7):1572-3
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  • [Title] FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin.
  • Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses.
  • [MeSH-major] Germ-Line Mutation / genetics. Keratosis, Seborrheic / genetics. Nevus / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics. Urinary Bladder Neoplasms / genetics

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  • [CommentOn] J Invest Dermatol. 2007 Jul;127(7):1664-6 [17255960.001]
  • (PMID = 17568799.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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7. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • Serial sections and immunohistochemical (IHC) analysis for CK17 and human papilloma virus (HPV) were performed on available materials.
  • Mean age at diagnostic was 56 years.
  • The lesions associated with TB were inverted follicular keratosis (IFK) in three cases, seborrhoeic keratosis (SK) in two cases and IFK with verruca vulgaris pattern in one case.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • The association of TB and IFK with direct connection between the lesions is another argument in favor of the follicular origin of IFK.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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8. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9

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  • [Title] [Acral keratoses and inverted follicular keratosis presenting Cowden disease].
  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Mucocutaneous lesions are the most constant and characteristic finding.
  • Inverted follicular keratosis as the presenting feature of Cowden disease is rare as the disease is usually suspected by the appearance of multiple facial trichilemmomas, oral mucosal papillomatosis and acral keratoses.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology

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  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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9. Noiles K, Vender R: Are all seborrheic keratoses benign? Review of the typical lesion and its variants. J Cutan Med Surg; 2008 Sep-Oct;12(5):203-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are all seborrheic keratoses benign? Review of the typical lesion and its variants.
  • BACKGROUND: Seborrheic keratosis (SK) is one of the more common benign epidermal neoplasms seen in adult and middle-aged patients.
  • RESULTS: Six subtypes of SK were identified: dermatosis papulosa nigra, stucco keratosis, inverted follicular keratosis, large cell acanthoma, lichenoid keratosis, and flat seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / classification. Skin Neoplasms / classification

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  • (PMID = 18845088.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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10. Zaballos P, Blazquez S, Puig S, Salsench E, Rodero J, Vives JM, Malvehy J: Dermoscopic pattern of intermediate stage in seborrhoeic keratosis regressing to lichenoid keratosis: report of 24 cases. Br J Dermatol; 2007 Aug;157(2):266-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic pattern of intermediate stage in seborrhoeic keratosis regressing to lichenoid keratosis: report of 24 cases.
  • BACKGROUND: Lichenoid keratosis (LK) is a well-described entity which has been proposed to represent an immunological or regressive response to pre-existing epidermal lesions such as solar lentigines or seborrhoeic keratoses.
  • OBJECTIVES: To evaluate the dermoscopic criteria of a series of cases of LK with remaining areas of seborrhoeic keratosis which were both dermoscopically and histologically diagnosed.
  • METHODS: Pigmented lesions with dermoscopic areas of seborrhoeic keratosis and LK in the same tumour were consecutively diagnosed and prospectively included in the study.
  • All pigmented lesions were examined and registered using DermLite Foto equipment (3Gen, LLC, Dana Point, CA, U.S.A.
  • ), at 10-fold magnification, at the Dermatology Department of Hospital de Sant Pau i Santa Tecla (Tarragona, Spain), between 1 January 2003 and 31 December 2005.
  • RESULTS: In total, 24 cases of lesions with dermoscopic areas of seborrhoeic keratosis and LK were collected.
  • In four lesions (17%), the clinical differential diagnosis without dermoscopy included malignant melanoma and in seven lesions (29%), basal cell carcinoma.
  • The diagnosis of LK was clinically considered without dermoscopy in only six cases (25%).
  • [MeSH-major] Keratosis / diagnosis. Lichenoid Eruptions / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Dermoscopy. Diagnosis, Differential. Disease Progression. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / pathology. Male. Melanoma / diagnosis. Middle Aged. Prospective Studies. Skin Neoplasms / diagnosis

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  • (PMID = 17553042.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Vun Y, De'Ambrosis B, Spelman L, Muir JB, Yong-Gee S, Wagner G, Lun K: Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation? Australas J Dermatol; 2006 May;47(2):106-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation?
  • A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer.
  • Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36).
  • There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas.
  • Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas.
  • Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis.
  • These lesions may represent malignant transformation within the seborrhoeic keratosis.
  • Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses.
  • Clinically, the remaining two were seborrhoeic keratoses.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Female. Head. Humans. Male. Medical Records. Middle Aged. Precancerous Conditions. Queensland / epidemiology. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637805.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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12. Kessler GM, Ackerman AB: Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective. Am J Dermatopathol; 2006 Dec;28(6):537-45
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  • [Title] Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective.
  • Squamous-cell carcinoma is the most common of all cancers and it develops in diverse organs of the body, among those being the skin, lung, gastrointestinal tract, and genitourinary tract, the latter including the cervix.
  • Unfortunately, no unanimity exists for naming very superficial squamous-cell carcinoma; it has not been designated in consistent fashion in a single organ, let alone in all of them, thereby resulting in confusion, not only in regard to terminology per se, but concerning matters conceptual, not the least of those being what appellation to apply to that condition when it is encountered histopathologically.
  • This vexing situation is illustrated graphically in the skin by diagnoses for very superficial squamous-cell carcinoma as disparate as solar keratosis (actinic keratosis, senile keratosis), arsenical keratosis, radiation keratosis, Bowen disease, bowenoid papulosis, squamous-cell carcinoma in situ, as well as variations on the theme of "keratinocytic intraepidermal neoplasia" and "dysplasia," and in the cervix by squamous-cell carcinoma in situ, leukoplakia, cervical intraepithelial neoplasia I-III, as well as variations on the theme of "squamous dysplasia ()."
  • There is a need urgently for a single term for very superficial squamous-cell carcinoma in every organ of the body in which it develops, to wit, one that conveys diagnosis in such logical, lucid, comprehensible fashion that it is understandable, readily and immediately, to clinicians.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Skin Neoplasms / classification. Uterine Cervical Neoplasms / classification

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  • (PMID = 17122500.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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13. Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA: [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol; 2006 Apr;81(4):217-9
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  • [Title] [Seborrheic keratosis of conjunctiva: a case report].
  • [Transliterated title] Queratosis seborreica de la conjuntiva: informe de un caso.
  • CASE REPORT: Pigmented conjunctival lesions are a diagnostic challenge for the clinician.
  • A 37-year-old man presented with a pigmented mass involving the conjunctiva of his right eye.
  • Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed.
  • The histopathologic diagnosis was seborrheic keratosis.
  • DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival pigmented lesions.
  • [MeSH-major] Conjunctival Diseases / pathology. Keratosis, Seborrheic / pathology

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  • (PMID = 16688646.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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14. Mabuchi T, Akasaka E, Kondoh A, Umezawa Y, Matsuyama T, Ozawa A: Seborrheic keratosis that follows Blaschko's lines. J Dermatol; 2008 May;35(5):301-3
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  • [Title] Seborrheic keratosis that follows Blaschko's lines.
  • A 66-year-old Japanese man had skin lesions on the left side of his trunk and the left upper extremity for approximately 10 years.
  • Clinical and histopathological findings led to a diagnosis of seborrheic keratosis that followed Blaschko's lines.
  • Our case supports the hypothesis that seborrheic keratosis can be associated with genetic mosaicism.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 18477232.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Mitsuhashi Y, Kawaguchi M, Hozumi Y, Kondo S: Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis. J Dermatol; 2005 Jun;32(6):420-3
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  • [Title] Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis.
  • Senile wart or seborrheic keratosis is a benign tumor which occurs mainly in the elderly.
  • We treated senile warts with topical vitamin D3 ointments (tacalcitol, calcipotriol or maxacalcitol).
  • An organ culture experiment using senile wart as a material with several concentrations of tacalcitol revealed that tacalcitol induced apoptosis in the tissue.
  • Vitamin D3 may affect senile warts by inducing apoptosis.
  • Clearance of senile warts, especially on exposed areas without pain, may improve the quality of life (QOL) of the elderly.
  • [MeSH-major] Cholecalciferol / therapeutic use. Keratosis, Seborrheic / drug therapy. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Administration, Topical. Adult. Age Factors. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies. Severity of Illness Index. Treatment Outcome

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  • (PMID = 16043912.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1C6V77QF41 / Cholecalciferol
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16. de Giorgi V, Massi D, Salvini C, Mannone F, Carli P: Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study. Clin Exp Dermatol; 2005 Jan;30(1):17-9
MedlinePlus Health Information. consumer health - Vulvar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study.
  • The diagnosis of seborrheic keratosis is, in general, a clinical one, but in some cases, the differential diagnosis between pigmented seborrheic keratosis and malignant melanoma is difficult.
  • Dermoscopy may improve the early diagnosis of vulvar melanoma and thus play a role in the preoperative classification of pigmented lesions at this particular site.
  • We report the first case of a pigmented seborrheic keratosis of the vulva clinically mimicking a malignant melanoma, whose dermoscopic features have been investigated together with their pathologic correlates.
  • Dermoscopy is therefore a useful method for the differential diagnosis of pigmented lesions even in the vulva.
  • [MeSH-major] Dermoscopy / standards. Keratosis, Seborrheic / pathology. Melanoma / pathology. Vulvar Diseases / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Dermatology / methods. Diagnosis, Differential. Female. Humans

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  • (PMID = 15663494.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Halleck P, Loddenkemper C, Hummel M, Scherer H, Haisch A: [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description]. HNO; 2009 May;57(5):480-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description].
  • [Transliterated title] Hyperkeratotische invertierte seborrhoische Keratose des äusseren Gehörgangs : Eine Erstbeschreibung.
  • Seborrheic keratosis is one of the most common benign neoplasms seen at the trunk, extremities, head and neck of older individuals which rarely occurs in the auditory canal.
  • Even rarer is the occurrence of an inverted or hyperkeratotic variant in this localization.
  • We present the clinical picture of a 74-year-old man with a recurrent hyperkeratotic, partially inverted seborrheic keratosis of the right external auditory canal.
  • This disease is sometimes difficult to diagnose, particulary to mark down malignant lesions.
  • An uncritical diagnosis must be avoided, since these lesions and especially the irritated subtype might be falsely assessed as basal cell carcinomas which they may resemble histologically.
  • [MeSH-major] Ear Diseases / diagnosis. Ear, External / pathology. Keratosis, Seborrheic / diagnosis

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  • [Cites] Otolaryngol Head Neck Surg. 1987 Feb;96(2):198-201 [2960940.001]
  • [Cites] J Korean Med Sci. 2001 Oct;16(5):619-22 [11641533.001]
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  • [Cites] J Dermatol Sci. 1992 Nov;4(3):166-71 [1337468.001]
  • (PMID = 17468841.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Wu YH, Hsiao PF, Lin YC: Verruciform xanthoma-like phenomenon in seborrheic keratosis. J Cutan Pathol; 2006 May;33(5):373-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Verruciform xanthoma-like phenomenon in seborrheic keratosis.
  • We report a 72-year-old man who had an asymptomatic 1-cm black nodule on his abdomen.
  • Histopathology showed a typical acanthotic type of seborrheic keratosis characterized by basaloid keratinocyte proliferation and pseudohorn cysts.
  • The presence of verruciform xanthomatous change in seborrheic keratosis provides further evidence that verruciform xanthoma may be a reactive phenomenon occurring in common skin disorders.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Xanthomatosis / pathology

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  • (PMID = 16640546.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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19. Tsai TM, Wu YH, Yang KC, Yang CY, Tsai TH, Chan JY: Sebaceous carcinoma associated with seborrheic keratosis. J Cutan Med Surg; 2010 Sep-Oct;14(5):240-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma associated with seborrheic keratosis.
  • BACKGROUND: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual.
  • OBJECTIVE: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings.
  • METHODS AND RESULTS: A 57-year-old man presented with an asymptomatic tumor on the skin of his abdomen that was composed of two separate but contiguous lesions.
  • Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis.
  • CONCLUSION: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20868621.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Neuhaus IM, LeBoit PE, McCalmont TM: Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ. J Am Acad Dermatol; 2006 Jan;54(1):132-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ.
  • BACKGROUND: We observed seborrheic keratoses with many basilar clear cells, creating a microscopic pattern that mimicked a seborrheic keratosis involved by melanoma in situ.
  • OBJECTIVE: We sought to report a series of these seborrheic keratoses and the immunohistochemical stains used to reach a proper diagnosis.
  • METHODS: We reviewed 9 cases of seborrheic keratosis that had a distinctive pattern of basal clear cells with ample cytoplasm.
  • RESULTS: The basal clear cells failed to react with Melan-A and S-100 protein antisera.
  • CONCLUSIONS: We describe a previously uncharacterized pattern of seborrheic keratosis that can microscopically mimic melanoma in situ.
  • Careful conventional microscopy coupled with a panel of immunostains can allow the proper diagnosis to be reached.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies. Antigens, Neoplasm. Diagnosis, Differential. Female. Humans. Immune Sera. Immunoenzyme Techniques. Keratins / immunology. MART-1 Antigen. Male. Middle Aged. Neoplasm Proteins / immunology. Retrospective Studies. S100 Proteins / immunology. Staining and Labeling

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  • [CommentIn] J Cutan Pathol. 2017 Jun;44(6):600-602 [28401581.001]
  • (PMID = 16384768.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Neoplasm; 0 / Immune Sera; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
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21. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants.
  • AIMS: Seborrheic keratoses are the most common benign cutaneous neoplasms in adult and middle-age patients.
  • There are six distinctive histopathologic variants of seborrheic keratosis, namely, acanthotic or solid, reticulated or adenoid, hyperkeratotic or papillomatous, clonal or nested, irritated and inflamed.
  • METHODS: We report two additional histopathologic variants of seborrheic keratosis.
  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • DISCUSSION: To our knowledge, these two histopathologic variants of seborrheic keratosis have been not previously described in the literature.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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22. Brodsky J: Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea. Curr Opin Otolaryngol Head Neck Surg; 2009 Aug;17(4):315-20
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for seborrheic keratosis .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea.
  • RECENT FINDINGS: Actinic keratosis can now be treated with photodynamic therapy or with many topical agents, as alternatives to traditional surgical techniques.
  • Seborrheic keratosis, as well as actinic keratosis and rosacea, are now often treated with laser therapy.
  • [MeSH-major] Facial Dermatoses / therapy. Keratosis, Actinic / therapy. Keratosis, Seborrheic / therapy. Rosacea / therapy

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  • (PMID = 19465852.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents
  • [Number-of-references] 46
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23. Bruecks AK, Kalia S, Trotter MJ: Overexpression of p27KIP1 in seborrheic keratosis. J Cutan Med Surg; 2007 Sep-Oct;11(5):174-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of p27KIP1 in seborrheic keratosis.
  • BACKGROUND: The pathogenesis of seborrheic keratosis (SK) is not well understood.
  • SKs are slow growing, but the details of cell cycle control in these lesions are not known.
  • [MeSH-major] Intracellular Signaling Peptides and Proteins / metabolism. Keratinocytes / metabolism. Keratosis, Seborrheic / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Proliferation. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Cyclin-Dependent Kinase Inhibitor p27. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Middle Aged. Skin / anatomy & histology. Skin / metabolism

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  • (PMID = 17942027.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / CDKN1B protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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24. Büyüklü F, Aydin H, Tarhan E, Ada S, Cakmak O: Seborrheic keratosis of the nasal vestibule. Kulak Burun Bogaz Ihtis Derg; 2007;17(5):298-300
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  • [Title] Seborrheic keratosis of the nasal vestibule.
  • Seborrheic keratosis is a common hyperkeratotic lesion of the epidermis, that usually occurs in the trunk and less frequently in the extremities, face, and the scalp.
  • An 80-year-old woman presented with a long-standing, slowly growing, firm, red-brown polypoid mass, 0.5 cm in size, located at the skin-mucosa interface of the right nasal vestibule.
  • The lesion was excised under local anesthesia and histopathologic examination showed seborrheic keratosis that mimicked squamous cell carcinoma.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 18187992.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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25. Pastar Z, Lipozencić J, Rados J, Stajminger G: Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma. Acta Dermatovenerol Croat; 2007;15(1):24-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma.
  • The diagnosis of seborrheic keratosis is a clinical diagnosis.
  • In a certain percentage of cases, differential diagnosis between seborrheic keratosis and malignant melanoma is difficult.
  • We describe a case of regressing seborrheic keratosis simulating malignant melanoma.
  • Clinical, dermoscopic and histopathologic examinations were performed for the occurrence of an asymmetric, irregularly demarcated, irregularly pigmented lesion measuring 1.3 x 1.5 cm on the right part of the abdomen in a 76-year-old male Caucasian.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Dermoscopy. Diagnosis, Differential. Humans. Male

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  • (PMID = 17433176.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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26. Sawada Y, Yoshiki R, Kawakami C, Nakamura M, Tokura Y: [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature]. J UOEH; 2009 Mar 1;31(1):51-5
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  • [Title] [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature].
  • A 78-year-old man was seen for a tumor on his umbilicus.
  • The excised tumor showed the acanthotic type of seborrheic keratosis.
  • Six cases of seborrheic keratosis arising on the umbilicus have been reported.
  • Our case is the first report of an acanthotic type of seborrheic keratosis on the umbilicus.
  • Seborrheic keratosis is one of the common skin tumors, but we hesitated in this diagnosis because of its abnormal location.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Umbilicus

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  • (PMID = 19297955.001).
  • [ISSN] 0387-821X
  • [Journal-full-title] Journal of UOEH
  • [ISO-abbreviation] J. UOEH
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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27. Askari SK, Schram SE, Wenner RA, Bowers S, Liu A, Bangerter AK, Warshaw EM: Evaluation of prospectively collected presenting signs/symptoms of biopsy-proven melanoma, basal cell carcinoma, squamous cell carcinoma, and seborrheic keratosis in an elderly male population. J Am Acad Dermatol; 2007 May;56(5):739-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of prospectively collected presenting signs/symptoms of biopsy-proven melanoma, basal cell carcinoma, squamous cell carcinoma, and seborrheic keratosis in an elderly male population.
  • BACKGROUND: Presenting signs/symptoms of skin cancer may aid in earlier detection and diagnosis.
  • OBJECTIVE: We sought to compare prospectively collected, presenting signs/symptoms of malignant melanoma (MM), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and seborrheic keratosis (SK).
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Humans. Male. Middle Aged. Prospective Studies. Skin Neoplasms / diagnosis


28. Hoshina D, Akiyama M, Hata H, Aoyagi S, Sato-Matsumura KC, Shimizu H: Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2007 Jan;32(1):54-6
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis.
  • An association between seborrhoeic keratosis (SK) and malignant tumours is considered to be rare.
  • We observed a case of eccrine porocarcinoma and Bowen's disease (BD) occurring synchronously, forming one lesion in a SK on the abdomen.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma / pathology. Eccrine Glands. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 17004985.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Braga JC, Scope A, Klaz I, Mecca P, Spencer P, Marghoob AA: Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis. J Am Acad Dermatol; 2008 May;58(5):875-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis.
  • Seborrheic keratosis is a common skin lesion that can usually be recognized either clinically or dermoscopically.
  • However, melanomas mimicking seborrheic keratoses, as well as melanomas arising in association with seborrheic keratoses, have been described.
  • We report the case of a patient with a lesion that initially revealed "classic" dermoscopic features of a seborrheic keratosis.
  • However, during follow-up, changes in color developed within the center of the lesion that led the clinician to the correct diagnosis of melanoma.
  • Dermatologists should be cognizant of "errors in perception"; we suggest that a final dermoscopic judgment of a seborrheic keratosis be rendered by combining the gestalt diagnosis of the overall pattern, with deliberate dermoscopic analysis of all quadrants of the lesion.
  • [MeSH-major] Diagnostic Errors. Head and Neck Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis


30. Hafner C, Hartmann A, van Oers JM, Stoehr R, Zwarthoff EC, Hofstaedter F, Landthaler M, Vogt T: FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Mod Pathol; 2007 Aug;20(8):895-903
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization.
  • Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man.
  • We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot multiplex assay.
  • Immunohistochemistry was performed for Ki-67, bcl-2 and FGFR3 protein in all seborrheic keratoses and 19 normal skin samples.
  • FGFR3 mutations were detected in 37 of 65 seborrheic keratoses (57%).
  • These mutations were found both in flat (initial) and thick seborrheic keratoses.
  • FGFR3 mutations were significantly associated with increased age and localization on the head and neck (P<0.01).
  • Ki-67 expression was significantly higher in seborrheic keratoses than in normal epidermis independent of the FGFR3 status (P<0.001).
  • Our results indicate that FGFR3 mutations can occur early in the pathogenesis of at least a subset of seborrheic keratoses.
  • Increased age appears to be a risk factor for these mutations.
  • The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Head and Neck Neoplasms / genetics. Keratosis, Seborrheic / genetics. Mutation. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Apoptosis. Cell Proliferation. DNA Mutational Analysis. Female. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Risk Factors

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  • (PMID = 17585316.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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31. Culbertson GR: 532-nm diode laser treatment of seborrheic keratoses with color enhancement. Dermatol Surg; 2008 Apr;34(4):525-8; discussion 528
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  • [Title] 532-nm diode laser treatment of seborrheic keratoses with color enhancement.
  • BACKGROUND: Seborrheic keratoses (SKs) are benign cutaneous tumors of the epidermis.
  • Hypopigmentation occurred in 6% of patients and was associated with old, chronic, or recalcitrant lesions.
  • [MeSH-major] Color Therapy. Keratosis, Seborrheic / therapy. Laser Therapy / methods. Lasers, Semiconductor

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  • (PMID = 18248487.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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32. Oyama N, Kaneko F: Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review. J Dermatol; 2008 Dec;35(12):782-5
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  • [Title] Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review.
  • The secondary skin malignancies arising in seborrheic keratosis (SK) are uncommon, and the causal association between the pre-existing lesion and subsequent malignant transformation remains uncertain.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Hair Diseases / pathology. Keratosis, Seborrheic / complications. Skin Neoplasms / pathology

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  • (PMID = 19239559.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. Zaballos P, Salsench E, Serrano P, Cuellar F, Puig S, Malvehy J: Studying regression of seborrheic keratosis in lichenoid keratosis with sequential dermoscopy imaging. Dermatology; 2010;220(2):103-9
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  • [Title] Studying regression of seborrheic keratosis in lichenoid keratosis with sequential dermoscopy imaging.
  • BACKGROUND: Lichenoid keratosis (LK) is a well-described entity that has been proposed to represent a regressive response to a pre-existent epidermal lesion.
  • AIMS: To evaluate the natural evolution of a series of cases showing the intermediate stage of the regression of seborrheic keratosis in LK using sequential dermoscopy imaging over time.
  • MATERIAL AND METHODS: A series of lesions with dermoscopic areas of seborrheic keratosis and LK in the same tumor were consecutively collected for over 3 years at the Dermatology Department of the Hospital de Sant Pau i Santa Tecla, Tarragona, Spain.
  • In 11 cases (50%), the seborrheic keratosis part disappeared completely, and in another 5 cases (22.7%), seborrheic keratosis comprised only 10% of the remaining area.
  • CONCLUSIONS: These dermoscopic study findings support the proposal that LK represents a regressive response to a pre-existent epidermal lesion, in this case seborrheic keratosis.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis. Lichen Planus / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19996577.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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34. Kopf AW, Rabinovitz H, Marghoob A, Braun RP, Wang S, Oliviero M, Polsky D: "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses. J Am Acad Dermatol; 2006 Dec;55(6):1089-91

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  • [Title] "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses.
  • "Fat fingers" are thick digitate linear, curvilinear, branched, or oval/circular dermoscopic structures typically seen in seborrheic keratoses where they represent the gyri of their cerebriform surfaces.
  • Their recognition is very useful in the diagnosis of these lesions, especially when the classic features (eg, milia, comedo-like openings) are absent.
  • Histologically and by confocal microscopy the "fat finger" gyri are accentuated by pigmented keratin filling the sulci.
  • "Fat fingers" must be differentiated from other linear structures such as "network-like structures"; branched streaks; network; globules; pigmented ovoid-nests; and streaks/pseudopods seen in different melanocytic and non-melanocytic lesions.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis

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  • (PMID = 17097405.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y, Furue M: Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol; 2009 Feb;160(2):442-5
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  • BACKGROUND: The enzyme mammalian target of rapamycin (mTOR) integrates many different cellular signals to control cell growth and proliferation, protein synthesis and breakdown, and other processes.
  • To date, there has been no report on the expression of protein kinase B (AKT)/mTOR cell signalling in epidermal tumours.
  • METHODS: Immunohistological staining was performed with phosphorylated (p-) AKT, p-mTOR, p-4E-binding protein 1 (p-4EBP1), p-ribosomal protein S6 (p-S6), p-p70 ribosomal protein S6 kinase 1 (p-p70S6K1) and CDK2 in 15 cases each of seborrhoeic keratosis, actinic keratosis, keratoacanthoma and Bowen's disease (BD), and 25 cases of squamous cell carcinoma (SCC).
  • [MeSH-major] Bowen's Disease / metabolism. Carcinoma, Squamous Cell / metabolism. Cyclin-Dependent Kinase 2 / metabolism. Keratosis, Actinic / pathology. Sirolimus / pharmacology. Skin Neoplasms / metabolism


36. Suiqing C, Min Z, Lirong C: Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol; 2005 May;32(5):354-60
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  • [Title] Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma.
  • In order to evaluate the possible effects of STAT3 phosphorylation and expression of E-cadherin on metastasis of some human epidermal non-melanoma cutaneous tumors, the expression of phosphorylated STAT3 (p-STAT3) and E-cadherin were analyzed by immunohistochemistry staining in formalin-fixed, paraffin-embedded tissue sections of human cutaneous squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and seborrhoeic keratosis (SK).
  • 3) E-cadherin was strongly expressed on the cell membranes of normal skin and SK, especially on basal cells.
  • E-cadherin was weakly expressed on cell membranes of SCC and BCC (p<0.001), whereas its expression was significantly lower in SCC than in BCC (p<0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Neoplasm Invasiveness / physiopathology. Skin Neoplasms / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy, Needle. Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / secondary. Case-Control Studies. Female. Humans. Immunohistochemistry. Keratosis, Seborrheic / metabolism. Keratosis, Seborrheic / pathology. Male. Probability. Prognosis. Reference Values. STAT3 Transcription Factor. Sensitivity and Specificity. Tissue Culture Techniques

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  • (PMID = 16043897.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Trans-Activators
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37. Ko CJ, Kim J, Phan J, Binder SW: Bcl-2-positive epidermal dendritic cells in inverted follicular keratoses but not squamous cell carcinomas or seborrheic keratoses. J Cutan Pathol; 2006 Jul;33(7):498-501
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  • [Title] Bcl-2-positive epidermal dendritic cells in inverted follicular keratoses but not squamous cell carcinomas or seborrheic keratoses.
  • AIM: In our previous research, bcl-2-positive dendritic cells were seen in increased numbers in suprabasal areas of inverted follicular keratoses (IFKs) compared to seborrheic keratoses (SKs).
  • The purpose of this study was twofold; firstly, to support that these dendritic cells are Langerhans cells and secondly, to contrast the epidermal dendritic cells in IFKs, squamous cell carcinomas (SCCs), and SKs.
  • SCCs showed bcl-2-positive cells only within the basal layer of the normal epidermis flanking the carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Darier Disease / metabolism. Keratosis, Seborrheic / metabolism. Langerhans Cells / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Antigens, CD1 / metabolism. Biomarkers, Tumor / metabolism. Cell Count. Humans. Immunohistochemistry

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  • (PMID = 16872473.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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38. Hafner C, López-Knowles E, Luis NM, Toll A, Baselga E, Fernández-Casado A, Hernández S, Ribé A, Mentzel T, Stoehr R, Hofstaedter F, Landthaler M, Vogt T, Pujol RM, Hartmann A, Real FX: Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A; 2007 Aug 14;104(33):13450-4
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  • [Title] Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
  • Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic mutations in epidermal nevi (EN) or as somatic mutations in seborrheic keratoses (SK).
  • [MeSH-major] Keratosis, Seborrheic / genetics. Mutation. Nevus / genetics. Phosphatidylinositol 3-Kinases / antagonists & inhibitors

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  • (PMID = 17673550.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Other-IDs] NLM/ PMC1948900
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39. Dalton SR, Gardner TL, Libow LF, Elston DM: Contiguous lesions in lentigo maligna. J Am Acad Dermatol; 2005 May;52(5):859-62
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  • Sampling error can have devastating consequences, especially if the biopsy demonstrates a pigmented lesion that was considered in the clinical differential diagnosis.
  • The presence of a solar lentigo, pigmented actinic keratosis, or reticulated seborrheic keratosis could mislead the pathologist and clinician to the erroneous conclusion that the incisional specimen is representative of the whole, and that no lentigo maligna is present.
  • OBJECTIVE: We have often observed the presence of a contiguous pigmented lesion adjacent to lentigo maligna.
  • METHODS: We studied Mohs debulking specimens of lentigo maligna, and broad shave biopsy specimens of pigmented lesions on heavily sun-damaged areas of the skin proven to be lentigo maligna.
  • RESULTS: Contiguous pigmented lesions were present in 48% of the specimens.
  • The most common lesion was a benign solar lentigo (30%), followed by pigmented actinic keratosis (24%).
  • [MeSH-minor] Biopsy / methods. Humans. Keratosis / diagnosis. Keratosis / pathology. Lentigo / diagnosis. Lentigo / pathology. Mohs Surgery / methods. Retrospective Studies

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  • (PMID = 15858478.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Shamsadini S, Wadji MB, Shamsadini A: Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign). Dermatol Online J; 2006;12(6):27
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  • [Title] Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign).
  • Paget disease of the breast, most often occurs in middle-aged women.
  • We report a patient with Paget disease of the nipple and intraductal carcinoma who presented with ipsilateral, eruptive grouped seborrheic keratoses of the areola and nipple of the breast.
  • [MeSH-major] Breast Diseases / etiology. Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Keratosis, Seborrheic / etiology. Paget's Disease, Mammary / diagnosis. Paraneoplastic Syndromes / etiology

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  • (PMID = 17083907.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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41. Foster KW, Moy RL, Fincher EF: Advances in plasma skin regeneration. J Cosmet Dermatol; 2008 Sep;7(3):169-79
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  • PSR has received US Food and Drug Administration 510 (k) clearance for treatment of rhytides of the body, superficial skin lesions, actinic keratoses, viral papillomata, and seborrheic keratoses.

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  • (PMID = 18789051.001).
  • [ISSN] 1473-2165
  • [Journal-full-title] Journal of cosmetic dermatology
  • [ISO-abbreviation] J Cosmet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Endothelium-Dependent Relaxing Factors; 31C4KY9ESH / Nitric Oxide
  • [Number-of-references] 14
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42. Rallan D, Bush NL, Bamber JC, Harland CC: Quantitative discrimination of pigmented lesions using three-dimensional high-resolution ultrasound reflex transmission imaging. J Invest Dermatol; 2007 Jan;127(1):189-95
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  • [Title] Quantitative discrimination of pigmented lesions using three-dimensional high-resolution ultrasound reflex transmission imaging.
  • The aim of this study was to produce and test numerical parameters from ultrasound skin images that would quantify the acoustic differences between common pigmented lesions, which may aid their discrimination from melanoma.
  • Those subsequently classified as malignant melanoma (MM), seborrheic keratosis (SK), and benign nevi by a consultant dermatologist (n=87) were imaged by high-resolution ultrasound-reflex transmission imaging.
  • Significant quantitative differences existed between benign and malignant pigmented lesions studied.
  • Sufficient discrimination was produced between MM (n=25), SKs (n=24) and other benign-pigmented lesions (n=38) to potentially reduce the referral of benign tumors by 65% without missing melanoma.
  • [MeSH-major] Imaging, Three-Dimensional. Keratosis, Seborrheic / ultrasonography. Melanoma / ultrasonography. Nevus / ultrasonography. Skin Neoplasms / ultrasonography


43. Hafner C, Vogt T: Seborrheic keratosis. J Dtsch Dermatol Ges; 2008 Aug;6(8):664-77
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  • [Title] Seborrheic keratosis.
  • Seborrheic keratosis is one of the most common skin tumors.
  • Despite its frequency, many aspects of seborrheic keratosis remain elusive.
  • In the last years new molecular genetic insights into seborrheic keratoses have been gained.
  • The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized.
  • [MeSH-major] Clinical Trials as Topic / trends. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / therapy

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  • (PMID = 18801147.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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44. Bon-Mardion M, Poulalhon N, Balme B, Thomas L: Ungual seborrheic keratosis. J Eur Acad Dermatol Venereol; 2010 Sep;24(9):1102-4
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  • [Title] Ungual seborrheic keratosis.
  • BACKGROUND/OBJECTIVES: Seborrheic keratoses are ubiquitous benign epithelial skin tumours.
  • We report herein the case of a seborrheic keratosis of the nail bed with typical histological features.
  • METHODS/RESULTS: A 58-year-old man presented with a 1-year-history of longitudinal leukoxanthonychia of the right hallux.
  • The diagnosis of typical seborrheic keratosis of the nail bed was made on histological examination.
  • CONCLUSION: To our knowledge, this is the first report of a typical, histologically documented seborrheic keratosis of the nail bed.
  • Therefore, this condition should be added to the differential diagnosis of acquired longitudinal leukoxanthonychia.
  • However, surgical treatment remains necessary to rule out other causes, including squamous cell carcinoma.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis. Nail Diseases / diagnosis

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  • (PMID = 20180892.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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45. Yanagi T, Shibaki A, Tsuji-Abe Y, Yokota K, Shimizu H: Epidermodysplasia verruciformis and generalized verrucosis: the same disease? Clin Exp Dermatol; 2006 May;31(3):390-3
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  • [Title] Epidermodysplasia verruciformis and generalized verrucosis: the same disease?
  • We report a patient with epidermodysplasia verruciformis (EV) who had severe generalized verrucous skin lesions for 50 years without any immunological abnormality.
  • Microscopic examination showed two histopathological features, including seborrhoeic keratosis and common warts.
  • The detected human papilloma virus (HPV) types were found to be HPV 3, 50, 5, and 76, using a degenerate PCR method.
  • [MeSH-minor] Antiviral Agents / therapeutic use. Calcitriol / analogs & derivatives. Calcitriol / therapeutic use. DNA, Viral / analysis. Etretinate / therapeutic use. Humans. Immunocompetence. Male. Middle Aged. Polymerase Chain Reaction. Warts / classification. Warts / drug therapy. Warts / pathology

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  • (PMID = 16681585.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 103909-75-7 / maxacalcitol; 65M2UDR9AG / Etretinate; FXC9231JVH / Calcitriol
  • [Number-of-references] 8
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46. Liu H, Chen S, Zhang F, Shi B, Shi Z, Zhang D, Yu M, Tian H, Yang B: Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy. Skin Res Technol; 2010 Nov;16(4):408-12
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  • [Title] Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy.
  • BACKGROUND: Differentiation of some seborrheic keratosis (SK) and verruca plana (VP) lesions is a challenge.
  • Confocal laser scanning microscopy (CLSM) has been proved to be useful in the diagnosis of skin diseases; however, to date, there is no report on the differential study of the two diseases with CLSM.
  • All the cases with lesions suggestive of SK or VP were advised to undergo imaging with CLSM, and if CLSM imaging reflected discordantly with the clinical diagnosis, a biopsy was suggested for the exact lesion imaged.
  • CONCLUSION: CLSM proved to be valuable in the differential diagnosis of SK and VP.
  • [MeSH-major] Dermoscopy / methods. Keratosis, Seborrheic / pathology. Microscopy, Confocal / methods. Warts / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Pilot Projects. Prospective Studies. Skin / pathology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 21039905.001).
  • [ISSN] 1600-0846
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Denmark
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47. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • [Title] Pityrosporum and seborrheic keratosis: an association.
  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, however, its potential role in association with SK's has not been evaluated as evidenced by the fact that there are no publications in the English-language literature regarding this issue.
  • We found that in a majority of the SK studied Pityrosporum was present, which was significantly different from controls (verruca vulgaris and basal cell carcinoma).
  • [MeSH-major] Dermatomycoses / complications. Keratosis, Seborrheic / etiology. Keratosis, Seborrheic / microbiology. Malassezia / isolation & purification

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Schulz H: [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?]. Hautarzt; 2010 Dec;61(12):1061-2
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  • [Title] [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?].
  • [Transliterated title] Pigmentierte Läsion der Schläfenregion. Melanozytärer Tumor, Basalzellkarzinom oder irritierte seborrhoische Keratose?
  • 33-year-old woman with a red-brown plaque on the temple.
  • Histopathological diagnosis revealed an irritated seborrheic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Facial Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adult. Biopsy. Dermoscopy. Diagnosis, Differential. Female. Forehead. Humans. Skin / pathology

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  • [Cites] Dermatol Clin. 2001 Apr;19(2):347-57 [11556243.001]
  • [Cites] Arch Dermatol. 2002 Dec;138(12):1556-60 [12472342.001]
  • (PMID = 21069503.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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49. Conscience I, Jovenin N, Coissard C, Lorenzato M, Durlach A, Grange F, Birembaut P, Clavel C, Bernard P: P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas. Eur J Dermatol; 2006 Sep-Oct;16(5):518-22
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  • BACKGROUND: Recently, an increased expression of P16, a cell cycle regulatory tumor suppressor protein, has been demonstrated in cervical squamous neoplasms as a marker of malignancy.
  • METHODS: Skin biopsy specimens with typical histologic features of squamous cell carcinoma (SCC; n = 30), Bowen's disease (BD; n = 17), basal cell carcinoma (BCC; n = 10), seborrheic keratosis (SK; n = 10) and normal human skin (NHS; n = 9) were obtained from 76 patients seen at our institution between 2001 and 2003.

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  • (PMID = 17101472.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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50. Goetze S, Ziemer M, Kaatz M, Lipman RD, Elsner P: Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study. Dermatol Surg; 2006 May;32(5):661-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study.
  • OBJECTIVE: To evaluate the wound-healing activity of a commercially available hydrocolloid wound dressing (Avery H2460, Avery Dennison, Turnhout, Belgium) in comparison with a control treatment (Fucidine cream with Cutiplast sterile dressing) in superficial wounds after surgical removal of seborrheic keratoses.
  • Sixteen patients between 18 and 80 years of age with seborrheic keratoses were enrolled.
  • [MeSH-major] Bandages, Hydrocolloid. Keratosis, Seborrheic / surgery

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  • (PMID = 16706761.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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51. Hafner C, Landthaler M, Mentzel T, Vogt T: FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. Br J Dermatol; 2010 Mar;162(3):508-12

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  • [Title] FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.
  • BACKGROUND: Stucco keratosis (STK) and dermatosis papulosa nigra (DPN) are referred to as variants of seborrhoeic keratosis.
  • OBJECTIVES: Because FGFR3 and PIK3CA mutations have been reported to be involved in the pathogenesis of seborrhoeic keratosis, we analysed whether these mutations are also present in STK and DPN.
  • The molecular genetic findings furthermore support the concept that both skin lesions are specific variants of seborrhoeic keratosis, sharing a common genetic background.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Phosphatidylinositol 3-Kinases / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics

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  • (PMID = 19845664.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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52. Dasanu CA, Alexandrescu DT: Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung. South Med J; 2009 Feb;102(2):216-8
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  • In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes.
  • The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers.

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  • (PMID = 19209445.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Graells J, Espinola A, Barrio C, Muñoz MD, Román A, Parellada N: [Minor cutaneous ambulatory surgery and cryotherapy. Comparative study between a dermatologist and family physicians]. Actas Dermosifiliogr; 2007 Apr;98(3):171-7
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  • [Transliterated title] Cirugía menor ambulatoria dermatológica y crioterapia. Estudio comparativo entre un dermatólogo y médicos de familia.
  • This study compares the diagnosis and treatment in cutaneous surgery, including cryotherapy, between a dermatologist and family physicians.
  • Each lesion was independently evaluated by a dermatologist and a family physician, both of whom assigned the clinical diagnosis and therapeutic advice.
  • Concordance for diagnosis, recommended treatment and indication for cryotherapy was calculated by Cohen's kappa coefficient.
  • Diagnostic concordance was significantly better for melanocytic nevus, achrocordon and for lesions with multiple and monomorphous presentation, and worse for isolated pigmented lesions.
  • For recommended treatment concordance was better for multiple and monomorphous lesions and worse for skin cancer and seborrheic keratosis.
  • For indication of cryotherapy concordance was worse for skin cancer, melanocytic nevus, acrochordon and seborrheic keratosis.
  • Family physicians should be more careful in evaluating solitary pigmented lesions and patients at risk for skin cancer.
  • [MeSH-major] Ambulatory Surgical Procedures. Cryotherapy. Dermatology. Family Practice. Observer Variation. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Clinical Competence. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / surgery. Keratosis, Seborrheic / therapy. Male. Middle Aged. Nevus, Pigmented / diagnosis. Nevus, Pigmented / surgery. Nevus, Pigmented / therapy. Prospective Studies. Sampling Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery. Skin Neoplasms / therapy. Warts / diagnosis. Warts / surgery. Warts / therapy

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  • (PMID = 17504701.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
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54. Hafner C, Di Martino E, Pitt E, Stempfl T, Tomlinson D, Hartmann A, Landthaler M, Knowles M, Vogt T: FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res; 2010 Jul 15;316(12):2008-16
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  • [Title] FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.
  • FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo.
  • However, at confluence FGFR3 mutant keratinocytes revealed a significantly higher cell number than wildtype cells.
  • Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo.
  • [MeSH-minor] Cell Adhesion. Cell Proliferation. Humans. Phosphorylation

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  • (PMID = 20420824.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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55. Goyal A, Raina S, Kaushal SS, Mahajan V, Sharma NL: Pattern of cutaneous manifestations in diabetes mellitus. Indian J Dermatol; 2010;55(1):39-41

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  • MATERIALS AND METHODS: One hundred consecutive patients with the diagnosis of diabetes mellitus and having skin lesions, either attending the diabetic clinic or admitted in medical wards were included in this study.
  • RESULTS: The common skin disorders were: Xerosis (44%), diabetic dermopathy (36%), skin tags (32%), cutaneous infections (31%), and seborrheic keratosis (30%).

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  • [Cites] J Dermatol. 1995 Oct;22(10):729-31 [8586750.001]
  • [Cites] Indian J Dermatol Venereol Leprol. 2003 Mar-Apr;69(2):105-8 [17642848.001]
  • [Cites] Diabetes Care. 2004 May;27(5):1047-53 [15111519.001]
  • [Cites] Diabetes Res Clin Pract. 1998 Feb;39(2):101-6 [9597379.001]
  • (PMID = 20418975.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2856371
  • [Keywords] NOTNLM ; Diabetes mellitus / Western Himalayas / skin lesions
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56. Takahara M, Chen S, Kido M, Takeuchi S, Uchi H, Tu Y, Moroi Y, Furue M: Stromal CD10 expression, as well as increased dermal macrophages and decreased Langerhans cells, are associated with malignant transformation of keratinocytes. J Cutan Pathol; 2009 Jun;36(6):668-74
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  • We analyzed CD10+ stromal cells, dermal macrophages and Langerhans cells (LCs) in skin tumors.
  • METHODS: Immunohistological staining was performed with markers for macrophages (CD68), LC (CD1a), stromal fibroblasts (CD10) and cell proliferation (Ki67) in 12 normal skins (NSs) and 15 cases each of seborrheic keratosis (SK), actinic keratosis (AK), keratoacanthoma (KA), Bowen's disease (BD) and squamous cell carcinoma (SCC).
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Keratinocytes / pathology. Langerhans Cells / pathology. Macrophages / pathology. Neprilysin / biosynthesis. Skin Neoplasms / pathology
  • [MeSH-minor] Bowen's Disease / immunology. Bowen's Disease / metabolism. Bowen's Disease / pathology. Carcinoma, Squamous Cell / immunology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Connective Tissue / immunology. Connective Tissue / metabolism. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Immunohistochemistry. Keratoacanthoma / immunology. Keratoacanthoma / metabolism. Keratoacanthoma / pathology. Keratosis, Actinic / immunology. Keratosis, Actinic / metabolism. Keratosis, Actinic / pathology. Keratosis, Seborrheic / immunology. Keratosis, Seborrheic / metabolism. Keratosis, Seborrheic / pathology. Skin / cytology. Skin Diseases / immunology. Skin Diseases / metabolism. Skin Diseases / pathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 19515046.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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57. El-Zawahry MB, Abdel El-Hameed El-Cheweikh HM, Abd-El-Rahman Ramadan S, Ahmed Bassiouny D, Mohamed Fawzy M: Ultrasound biomicroscopy in the diagnosis of skin diseases. Eur J Dermatol; 2007 Nov-Dec;17(6):469-75
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  • [Title] Ultrasound biomicroscopy in the diagnosis of skin diseases.
  • We aimed to evaluate the accuracy of ultrasound biomicroscopy (UBM) in the diagnosis of eight skin disorders namely, morphea, keloid, lichen planus, chronic eczema, psoriasis, port wine stain, seborrheic keratosis, and photo-aged skin, through correlation of its findings with clinical and pathological assessment.
  • In morphea, the dermal echogenicity was increased and the thickness of morphea plaques correlated significantly with disease severity.
  • Seborrheic keratosis appeared as a sound shadow.
  • We conclude that UBM is a non-invasive diagnostic tool in dermatology which can be used to give valuable information about disease progress and the effectiveness of therapy.

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  • (PMID = 17951126.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] France
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58. Blomberg M, Jeppesen EM, Skovby F, Benfeldt E: FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature. Dermatology; 2010;220(4):297-305
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  • We present a 14-year-old girl with mild hypochondroplasia who developed acanthosis nigricans.
  • We review the present literature, describing studies in which FGFR3 mutations have been investigated in skin lesions: primarily seborrheic keratoses and epidermal nevi, but also other benign skin tumors and a single case of a squamous cell carcinoma.
  • [MeSH-minor] Adolescent. Blood Glucose / drug effects. C-Peptide / blood. Female. Gonadotropin-Releasing Hormone / therapeutic use. Human Growth Hormone / therapeutic use. Humans. Keratosis, Seborrheic / genetics. Metformin / therapeutic use

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20453470.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 12629-01-5 / Human Growth Hormone; 33515-09-2 / Gonadotropin-Releasing Hormone; 9100L32L2N / Metformin; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Number-of-references] 54
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59. Benvenuto-Andrade C, Dusza SW, Agero AL, Scope A, Rajadhyaksha M, Halpern AC, Marghoob AA: Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions. Arch Dermatol; 2007 Mar;143(3):329-38
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  • Qualitative assessment suggested that melanin appeared darker and blue nevi had more shades of blue on PD compared with NPD images; vessels and red areas were better visualized with PD, suggesting that PD may be helpful in identifying malignancies; milialike cysts and comedolike openings were better visualized with NPD, suggesting that NPD is more helpful for identification of seborrheic keratosis; peppering, lighter colors, and blue-white areas were more evident under NPD, facilitating recognition of regression areas; and shiny-white streaks, possibly representing fibrosis, were seen more clearly under PD.
  • Further studies are needed to evaluate the effect of these differences on clinical diagnosis.


60. de Giorgi V, Massi D, Sestini S, Alfaioli B, Carelli G, Carli P: Cutaneous collision tumour (melanocytic naevus, basal cell carcinoma, seborrhoeic keratosis): a clinical, dermoscopic and pathological case report. Br J Dermatol; 2005 Apr;152(4):787-90
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  • [Title] Cutaneous collision tumour (melanocytic naevus, basal cell carcinoma, seborrhoeic keratosis): a clinical, dermoscopic and pathological case report.
  • The most common association, basal cell carcinoma (BCC) and naevus, is very difficult to diagnose clinically.
  • We describe a 38-year-old woman with a previous history of melanoma, who presented with a modified pigmented lesion of the hip that had begun to change 6 months earlier.
  • Histologically, the lesion was a melanocytic compound naevus and a BCC with a seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Keratosis, Seborrheic / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermoscopy / methods. Diagnosis, Differential. Female. Hip. Humans. Melanoma / diagnosis

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  • (PMID = 15840116.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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61. Siqueira CR, Miot HA: [Inflammation of multiple seborrheic keratoses induced by chemotherapy with gemcitabine]. An Bras Dermatol; 2009 Jul-Aug;84(4):410-3

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  • [Title] [Inflammation of multiple seborrheic keratoses induced by chemotherapy with gemcitabine].
  • [Transliterated title] Inflamação de queratoses seborreicas múltiplas induzida por quimioterapia com gencitabina.
  • The authors report inflammation in multiple seborrheic keratoses after chemotherapy with gemcitabine in a patient under treatment for pancreatic cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Deoxycytidine / analogs & derivatives. Drug Eruptions / complications. Drug Eruptions / etiology. Keratosis, Seborrheic / chemically induced. Keratosis, Seborrheic / complications

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  • (PMID = 19851675.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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62. Slobodin G, Lurie M, Munichor M, Kovalev J, Rosner I: Gottron's papules-like eruption developing under hydroxyurea therapy. Rheumatol Int; 2006 Jun;26(8):768-70
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  • A 57-year-old white female developed a Gottron's papules (GP)-like eruption, without any of the other clinical or laboratory signs of dermatomyositis (DM).
  • Skin biopsy was compatible with seborrheic keratosis.
  • [MeSH-major] Dermatomyositis / diagnosis. Hydroxyurea / adverse effects. Hydroxyurea / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy

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  • (PMID = 16583187.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] X6Q56QN5QC / Hydroxyurea
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63. Tan E, Oakley A, Soyer HP, Haskett M, Marghoob A, Jameson M, Rademaker M: Interobserver variability of teledermoscopy: an international study. Br J Dermatol; 2010 Dec;163(6):1276-81
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  • BACKGROUND: Teledermoscopy is a rapidly developing field of dermatology with studies demonstrating excellent agreement with face-to-face diagnosis.
  • However, we are unaware of studies evaluating interobserver variability in diagnosis between dermatologists from different continents.
  • RESULTS: There was excellent agreement between four of five dermatologists (A-D) for lesions that were agreed upon as melanoma (κ = 0·81-0·97) and benign naevus (κ = 0·77-0·82).The fifth dermatologist (E) made a more frequent diagnosis of atypical naevus and melanoma than the others.
  • For nonmelanocytic lesions, there was moderate to very good agreement for seborrhoeic keratosis (κ = 0·64-0·80) and basal cell carcinoma (κ = 0·55-0·67), but poor agreement for invasive squamous cell carcinoma (SCC) (κ = 0·05-0·15).
  • Agreement for actinic keratosis (κ = 0·32-0·67) and SCC in situ (κ = 0·15-0·32) was only moderate.
  • When atypical and benign naevi were grouped together and actinic keratosis and SCC in situ grouped together, there was better agreement among all dermatologists.
  • CONCLUSIONS: There was good agreement among dermatologists A-D but dermatologist E varied from the group with more frequent diagnosis of melanoma and atypical naevus.
  • [MeSH-major] Dermoscopy / methods. Remote Consultation / standards. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20795998.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Lipozenčić J, Bukvić Mokos Z: Dermatologic lasers in the treatment of aging skin. Acta Dermatovenerol Croat; 2010;18(3):176-80
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  • The major clinical features of aging skin include xerosis, laxity, wrinkles, slackness, and the occurrence of benign neoplasms such as seborrheic keratoses and cherry angiomas.
  • Photoaging is characterized by dryness (roughness), actinic keratoses, irregular pigmentation (freckling, lentigines, guttate hypomelanosis, persistent hyperpigmentation), wrinkling, stellate pseudoscars, elastosis (fine nodularity and/or coarseness), inelasticity, telangiectasia, venous lakes, purpura (easy bruising), comedones (maladie de Favre et Racouchot) and sebaceous hyperplasia.
  • In this manuscript laser resurfacing and laser therapy of vascular and pigmented lesions of aging skin will be overviewed.

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  • (PMID = 20887699.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
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65. Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM, Real FX: Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors. J Invest Dermatol; 2007 Jul;127(7):1664-6
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  • Based on the occurrence of fibroblast growth factor receptor 3 (FGFR3) mutations in seborrheic keratosis and urothelial carcinomas (UC), and the identification of two young patients with EN and UC, we hypothesized that mutations might occur in EN.
  • [MeSH-minor] Adult. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Humans. Keratosis, Seborrheic / genetics. Keratosis, Seborrheic / metabolism. Male. Mosaicism. Skin / metabolism. Urothelium / metabolism

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  • [CommentIn] J Invest Dermatol. 2007 Jul;127(7):1572-3 [17568799.001]
  • (PMID = 17255960.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Number-of-references] 19
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66. Kebria MM, Belinson J, Kim R, Mekhail TM: Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature. Gynecol Oncol; 2006 May;101(2):353-5
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  • [Title] Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.
  • The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy.
  • CASE: A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat.
  • [MeSH-minor] Acanthosis Nigricans / complications. Female. Hand Dermatoses / complications. Humans. Keratoderma, Palmoplantar / complications. Keratosis, Seborrheic / complications. Middle Aged. Paraneoplastic Syndromes / complications


67. Fukushige T, Kanekura T, Ohuchi E, Shinya T, Kanzaki T: Immunohistochemical studies comparing the localization of type XV collagen in normal human skin and skin tumors with that of type IV collagen. J Dermatol; 2005 Feb;32(2):74-83
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  • It was expressed at low levels in seborrheic keratosis and not expressed at all in actinic keratosis and squamous cell carcinoma.
  • [MeSH-minor] Basement Membrane / metabolism. Carcinoma, Squamous Cell / metabolism. DNA, Complementary / analysis. Humans. Immunohistochemistry. Keratosis / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism

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  • (PMID = 15906535.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA, Complementary; 9007-34-5 / Collagen
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68. Craig S, Bui-Mansfield LT, Lusk JD: Radiology pathology conference of Brooke Army Medical Center: trichoblastoma of breast. Clin Imaging; 2009 Jul-Aug;33(4):311-3
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  • The differential diagnosis of a superficial breast lesion detected on mammography typically includes seborrheic keratosis, dermal nevus, epidermal inclusion cyst, and basal cell carcinoma with subcutaneous invasion [Kopans DB.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography / methods

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  • (PMID = 19559355.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Arai E, Shimizu M, Tsuchida T, Izaki S, Ogawa F, Hirose T: Lymphomatoid keratosis: an epidermotropic type of cutaneous lymphoid hyperplasia: clinicopathological, immunohistochemical, and molecular biological study of 6 cases. Arch Dermatol; 2007 Jan;143(1):53-9
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  • [Title] Lymphomatoid keratosis: an epidermotropic type of cutaneous lymphoid hyperplasia: clinicopathological, immunohistochemical, and molecular biological study of 6 cases.
  • OBJECTIVE: To provide evidence that lymphomatoid keratosis should be categorized as an epidermotropic subtype of cutaneous lymphoid hyperplasia.
  • DESIGN: Clinicopathological, immunohistochemical, and molecular biological studies of epidermotropic and dermal bandlike infiltrates of lymphocytes without necrotic keratinocytes, Civatte bodies, or Max-Joseph spaces and solar lentigo or seborrheic keratosis adjacent to the lesion, but with epidermal hyperplastic change (clinically scaly plaque) in cases of lymphomatoid keratosis.
  • Gene rearrangement of the immunoglobulin heavy chain gene and T-cell receptor (TCR)-beta and TCRgamma genes was also investigated by the polymerase chain reaction method.
  • In the upper dermal lymphocytic infiltrates, the CD3(+)/CD79a(+) cell ratio ranged from 5:5 to 8:2.
  • The CD4(+)/CD8(+) cell ratio was within normal limits.
  • CONCLUSIONS: Our results indicate that lymphomatoid keratosis is a clinically benign keratotic lesion but histologically malignant, simulating mycosis fungoides.
  • Therefore, "lymphomatoid" keratosis should be classed as a pseudolymphoma, namely, a subtype of cutaneous lymphoid hyperplasia with epidermotropism.
  • [MeSH-major] Gene Rearrangement. Keratosis / pathology. Pseudolymphoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD20. Antigens, CD79. B-Lymphocytes / immunology. CD4-CD8 Ratio. Diagnosis, Differential. Female. Genes, T-Cell Receptor beta. Genes, T-Cell Receptor gamma. Humans. Immunohistochemistry. Japan. Male. Medical Records. Middle Aged. Molecular Biology. Polymerase Chain Reaction. Retrospective Studies. T-Lymphocytes / immunology

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  • (PMID = 17224542.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79
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70. Logié A, Dunois-Lardé C, Rosty C, Levrel O, Blanche M, Ribeiro A, Gasc JM, Jorcano J, Werner S, Sastre-Garau X, Thiery JP, Radvanyi F: Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet; 2005 May 1;14(9):1153-60
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  • Here, we targeted an activated receptor mutant (S249C FGFR3) to the basal cells of the epidermis of transgenic mice.
  • These skin lesions had features in common with acanthosis nigricans and other benign human skin tumors, including seborrheic keratosis, one of the most common benign epidermal tumors in humans.
  • We therefore screened a series of 62 cases of seborrheic keratosis for FGFR3 mutations.
  • [MeSH-major] Gene Expression. Keratosis, Seborrheic / genetics. Point Mutation. Protein-Tyrosine Kinases / genetics. Receptors, Fibroblast Growth Factor / genetics. Skin Neoplasms / genetics

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  • (PMID = 15772091.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Fgfr3 protein, mouse; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; G34N38R2N1 / Bromodeoxyuridine
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71. Kim JY, Kim HS, Lee S, Park JH: The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. Pathol Res Pract; 2010 May 15;206(5):295-9
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  • [Title] The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin.
  • We performed an immunohistochemical examination of GLTSCR2 expression in samples of seborrheic keratosis (SK, n=69), a common benign skin tumor, and normal skin (n=23), and assessed the relationship between GLTSCR2 expression and the patients' clinicopathologic factors.
  • Our results showed that GLTSCR2 expression in SK was significantly lower than in normal skin (p<0.001), and this decreased expression of GLTSCR2 was associated with patient age (p=0.045).
  • [MeSH-major] Keratosis, Seborrheic / metabolism. Skin / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] (c) 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20185249.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / GLTSCR2 protein, human; 0 / Tumor Suppressor Proteins
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72. Hafner C, Toll A, Fernández-Casado A, Earl J, Marqués M, Acquadro F, Méndez-Pertuz M, Urioste M, Malats N, Burns JE, Knowles MA, Cigudosa JC, Hartmann A, Vogt T, Landthaler M, Pujol RM, Real FX: Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A; 2010 Nov 30;107(48):20780-5
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  • Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Keratosis, Seborrheic / pathology. Mutation / genetics. Oncogenes / genetics
  • [MeSH-minor] Apoptosis / genetics. Biomarkers, Tumor. Cell Aging. Cell Proliferation. Clone Cells. DNA Mutational Analysis. Genetic Testing. Genome, Human / genetics. Genotype. Humans. Mitogen-Activated Protein Kinases / genetics. PTEN Phosphohydrolase / metabolism. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins c-akt / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Signal Transduction / genetics. TOR Serine-Threonine Kinases / metabolism. Tumor Suppressor Proteins / metabolism. ras Proteins / genetics


73. Andres C, Belloni B, Puchta U, Sander CA, Flaig MJ: Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors. J Cutan Pathol; 2010 Jan;37(1):28-34
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  • [Title] Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors.
  • BACKGROUND: Merkel cell polyomavirus (MCPyV) is the likely causative agent of Merkel cell carcinoma (MCC).
  • METHODS: A molecular pathology study was performed in 33 MCC samples and 33 age- and sex-matched samples of sun exposed non-MCC tumors [12 seborrheic keratoses (SK), 11 basal cell carcinomas (BCC) and 10 lentigo maligna melanomas (LMM)].
  • Speculative, prevalence of MCPyV in an age- and sex-matched non-MCC population could average up to 6%.
  • [MeSH-major] Carcinoma, Merkel Cell / virology. Hutchinson's Melanotic Freckle / virology. Neoplasms, Basal Cell / virology. Polyomavirus / isolation & purification. Polyomavirus Infections / complications. Skin Neoplasms / virology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Viral, Tumor / analysis. Comorbidity. DNA, Neoplasm / analysis. DNA, Viral / analysis. Female. Germany / epidemiology. Humans. Keratosis, Seborrheic / pathology. Keratosis, Seborrheic / virology. Male. Middle Aged. Sex Factors. Skin / pathology. Skin / virology. Skin Aging

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 19615033.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Neoplasm; 0 / DNA, Viral
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74. Naruke Y, Nakashima M, Suzuki K, Matsuu-Matsuyama M, Shichijo K, Kondo H, Sekine I: Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability. Cancer Sci; 2008 May;99(5):946-51
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  • The levels of GIN were analyzed by immunofluorescence studies of 53BP1 in 56 skin tumors that included 20 seborrheic keratosis, eight actinic keratosis, nine Bowen's disease, nine squamous cell carcinoma, and 10 basal cell carcinoma.
  • Because actinic keratosis showed a high DDR type of 53BP1 immunoreactivity, GIN seems to be induced at the precancerous stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Nucleus / metabolism. Epidermis / metabolism. Female. Fluorescent Antibody Technique. Gene Expression. Humans. Male. Middle Aged

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  • (PMID = 18380789.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human
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75. Obata H, Aoki Y, Kubota S, Kanai N, Tsuru T: [Incidence of benign and malignant lesions of eyelid and conjunctival tumors]. Nippon Ganka Gakkai Zasshi; 2005 Sep;109(9):573-9

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  • The incidence of benign or malignant lesions, the pathological classification, age, sex, and clinical diagnostic accuracy were all investigated.
  • The common benign eyelid tumors were 14 nevocellular nevi, 9 seborrheic keratosis, 7 epidermoid cysts, and 6 papillomas.
  • These included 9 basal cell carcinomas, 9 sebaceous gland carcinomas, 4 malignant lymphomas, and 2 metastatic tumors.
  • Thirty-four (79%) conjunctival tumors were benign, and the common benign conjunctival tumors were 9 nevocellular nevi and 7 papillomas.
  • Nine (21%) conjunctival tumors were malignant, comprising 7 malignant lymphomas and 2 squamous cell carcinomas.
  • Clinical accuracy in predicting basal cell carcinoma and sebaceous gland carcinoma was 11.1% and 44.4%, respectively.
  • Excised eyelid lesions should be submitted for histopathologic confirmation because there are some cases where clinical diagnosis does not match pathological diagnosis.
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Female. Humans. Incidence. Lymphoma / epidemiology. Lymphoma / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16218435.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 27
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76. Li P, Gao XH, Chen HD, Zhang Y, Wang Y, Wang H, Wang Y, Xie Y: Localization of haptoglobin in normal human skin and some skin diseases. Int J Dermatol; 2005 Apr;44(4):280-4
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  • Haptoglobin can also be detected in the cytoplasm of normal epidermal Langerhans cells (LCs), and can prevent their functional maturation.
  • METHODS: We examined Hp expression at mRNA and protein levels by in situ hybridization and immunohistochemistry, respectively, in normal human skin and in the skin of patients with psoriasis, lichen planus, erythroderma, seborrheic keratosis, verruca vulgaris, basal cell carcinoma, systemic lupus erythematosus, pemphigus and bullous pemphigoid. RESULTS:.
  • (1) Haptoglobin mRNA was expressed in the epidermal keratinocytes (KCs), the epithelial cells of hair follicles, sebaceous glands and eccrine glands in normal skin and all dermatoses investigated. (2) Whereas compared with normal skin, the Hp mRNA in KCs of patients with psoriasis, lichen planus, erythroderma, seborrhoea keratosis and verruca vulgaris was significantly intensified, it was weaker in patients with systemic lupus erythematosus, pemphigus and bullous pemphigoid. (3) Haptoglobin protein only stained positively in some KCs of patients with psoriasis, lichen planus and erythroderma. (4) Although some but not all epidermal LCs were positively stained with anti-Hp antibody in normal skin and in skin samples from all patients, the ratios of Hp-positive LCs/total LCs were significantly higher in those diseases with intensified Hp mRNA in KCs.
  • The expression of Hp mRNA in KCs and the Hp protein in both LCs and KCs appears to be correlated with the amount of inflammation, which might indicate that skin itself is involved in down-regulating the local inflammatory reaction by KC-synthesized Hp.

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  • (PMID = 15811077.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Haptoglobins
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77. Kocyigit P, Akay BN, Arica E, Anadolu RY, Erdem C: Post-renal transplantation Leser-Trélat sign associated with carcinoma of the gallbladder: a rare association. Scand J Gastroenterol; 2007 Jun;42(6):779-81
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  • The sign of Leser-Trélat represents the sudden appearance of multiple seborrheic keratoses in association with an underlying malignancy.
  • Here, we report on a 57-year-old man who presented with a sudden increase in the number and size of seborrheic keratoses, particularly on sun-exposed areas 24 years after renal transplantation.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Keratosis, Seborrheic / pathology. Kidney Transplantation

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  • (PMID = 17506003.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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78. Kullander J, Forslund O, Dillner J: Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev; 2009 Feb;18(2):472-8
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  • [Title] Staphylococcus aureus and squamous cell carcinoma of the skin.
  • Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought.
  • We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with biopsies from healthy skin of these 353 immunocompetent patients.
  • In a S. aureus-specific PCR, targeting the nuc gene, presence of S. aureus DNA was strongly associated with SCC (29.3% positive specimens; adjusted odds ratio, 6.23; 95% confidence interval, 3.10-12.53) compared with healthy skin (5.7% positive specimens).
  • There was also a tendency for association of S. aureus with actinic keratosis, but no association was found for basal cell carcinoma or seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Squamous Cell / microbiology. Staphylococcus aureus / isolation & purification
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / microbiology. Case-Control Studies. DNA, Bacterial / analysis. Female. Humans. Keratosis, Actinic / microbiology. Keratosis, Seborrheic / microbiology. Logistic Models. Male. Middle Aged. Polymerase Chain Reaction. Precancerous Conditions / microbiology

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  • (PMID = 19155437.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial
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79. Hida Y, Kubo Y, Arase S: Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours. Br J Dermatol; 2009 Jun;160(6):1258-63
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  • METHODS: We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • RESULTS: Activated point mutations of FGFR3 were identified in four of 22 cases (18%) of seborrhoeic keratosis, but no mutation was detected in the other skin tumours.
  • Twenty-seven of 31 cases (87%) of seborrhoeic keratosis showed moderately to strongly positive expression of the FGFR3 protein, but almost all the other skin tumours were negative.
  • On the other hand, almost all the seborrhoeic keratoses showed negative immunoreactivity for antiphoshohistone H2AX (gamma-H2AX) as a marker of OIS, but 17 of 22 cases (77%) of AK were moderately to strongly positive.
  • Immunoreactivity for gamma-H2AX was significantly greater in AK than in seborrhoeic keratosis, BD, BCC and SCC.
  • CONCLUSIONS: The activation of FGFR3 might be a common feature in the tumorigenesis in seborrhoeic keratosis, although the activation does not induce a typical oncogenic signal in keratinocytes.
  • [MeSH-minor] Bowen's Disease / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Squamous Cell / genetics. Chi-Square Distribution. Humans. Keratosis, Actinic / genetics. Keratosis, Seborrheic / genetics. Point Mutation / genetics. Transcriptional Activation

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  • (PMID = 19298285.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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80. Sakakibara A, Kamijima M, Shibata S, Yasue S, Kono M, Tomita Y: Dermoscopic evaluation of vascular structures of various skin tumors in Japanese patients. J Dermatol; 2010 Apr;37(4):316-22
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  • Dermoscopic analysis of skin tumor has been mainly focused on pigmented structures.
  • Recently, several different morphological types of vessels were found to be well associated with pigmented or non-pigmented skin tumors in white subjects.
  • As little statistical information on the various pigmented skin tumor vessels of Japanese patients has been reported, we therefore tried to evaluate the association between various vascular structures and 741 tumor lesions of Japanese patients.
  • Vascular structures were dermoscopically recognized in 41 of 102 cases of melanoma, 104 of 119 basal cell carcinoma (BCC), 86 of 257 seborrheic keratosis (SK), 35 of 210 dermal and compound nevus (DN/CN), six of 12 squamous cell carcinoma (SCC) and 16 of 41 Bowen disease (BD).
  • The structures of arborizing and glomerular vessels statistically revealed diagnostic specificity for BCC and BD, respectively, and hairpin vessels were helpful for differentiating SK from other pigmented tumors, as already reported in white patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Asian Continental Ancestry Group. Blood Vessels / pathology. Bowen's Disease / blood supply. Bowen's Disease / diagnosis. Carcinoma, Basal Cell / blood supply. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / diagnosis. Female. Humans. Japan. Keratosis, Seborrheic / blood. Keratosis, Seborrheic / diagnosis. Male. Melanoma / blood supply. Melanoma / diagnosis. Middle Aged. Nevus / blood supply. Nevus / diagnosis. Retrospective Studies. Young Adult

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  • (PMID = 20507400.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Tran H, Bossenbroek NM, Rosenman K, Meehan SA, Sanchez M, Prystowsky S: Steroid-responsive facial eruption with cornoid lamellae--a possible new entity. Dermatol Online J; 2008;14(10):9
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  • The histopathologic presence of a cornoid lamella is often associated with a diagnosis of porokeratosis.
  • However, this feature is not pathognomonic for porokeratosis and can be found in a number of other dermatologic conditions, which include seborrheic keratosis, verruca vulgaris, actinic keratosis, squamous-cell carcinoma in situ, basal-cell carcinoma, milia, and scar.
  • As such, this pattern is not specific for any given disease process.
  • [MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Antiviral Agents / therapeutic use. Diagnosis, Differential. Glucocorticoids / therapeutic use. Hepatitis C / drug therapy. Humans. Inflammation. Interferon-alpha / therapeutic use. Male. Middle Aged. Polyethylene Glycols. Porokeratosis / diagnosis. Recombinant Proteins

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  • (PMID = 19061608.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antiviral Agents; 0 / Glucocorticoids; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 99210-65-8 / interferon alfa-2b
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82. Hatta N, Hirano T, Kimura T, Hashimoto K, Mehregan DR, Ansai S, Takehara K, Takata M: Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol; 2005 Feb;32(2):131-6
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  • [Title] Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
  • BACKGROUND: Distinguishing basal cell carcinoma (BCC) from other benign and malignant skin tumors is sometimes a difficult task for the pathologists.
  • Because the activation of hedgehog signals and the up-regulation of its critical transcriptional factor Gli1 are well documented in BCC, a molecular technique measuring Gli1 transcripts may aide the diagnosis.
  • The tumors included BCC (21), squamous cell carcinoma (13), seborrheic keratoses (8), trichoepithelioma (5), eccrine poroma/porocarcinoma (4), and sebaceous epithelioma/carcinoma (2).
  • The diagnosis was discordant among three pathologists in the remaining 15 tumors.
  • Histological diagnoses included BCC, BCC with sebaceous differentiation, sebaceoma/sebaceous epithelioma, trichoblastoma, trichoepithelioma, basaloid follicular harmartoma, basosquamous carcinoma, etc.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Oncogene Proteins / metabolism. Skin Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription, Genetic

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  • (PMID = 15606671.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gli protein; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / Transcription Factors
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83. Lim C: Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol; 2006 May;47(2):109-13

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  • [Title] Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions.
  • Seborrhoeic keratoses are benign epidermal neoplasms that are rarely associated with other skin lesions especially malignancies.
  • In this study, the aim was to assess the incidence of associated lesions occurring either adjacent to or contiguous with a seborrhoeic keratosis.
  • In total, 639 consecutive histologically diagnosed seborrhoeic keratoses were identified, of which 85 (9%) were found to be associated with other lesions.
  • Of these associated lesions, 44 (7%) were malignant, with four of these found to be arising within the seborrhoeic keratosis.
  • The average age was 74 years (range 33-98 years).
  • Seborrhoeic keratoses associated with other lesions were found most commonly on the head and neck.
  • The incidence of associated lesions, in particular malignancy arising within seborrhoeic keratoses may be higher than previously thought.
  • This may be an incidental phenomenon, or seborrhoeic keratosis could represent a precursor lesion.
  • Therefore, seborrhoeic keratoses that have undergone recent clinical change should be considered for biopsy and histological examination.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Extremities. Head. Humans. Medical Records. Melanoma / epidemiology. Melanoma / etiology. Melanoma / pathology. Middle Aged. Neck. New South Wales / epidemiology. Precancerous Conditions. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637806.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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84. Hafner C, Hartmann A, Real FX, Hofstaedter F, Landthaler M, Vogt T: Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses. J Invest Dermatol; 2007 Aug;127(8):1883-5

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  • [Title] Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.
  • Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK).
  • [MeSH-major] Keratosis, Seborrheic / genetics. Mutation. Receptor, Fibroblast Growth Factor, Type 3 / metabolism

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  • (PMID = 17392824.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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85. Minagawa A, Koga H: Dermoscopy of pigmented poromas. Dermatology; 2010 Aug;221(1):78-83
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  • [Title] Dermoscopy of pigmented poromas.
  • BACKGROUND: To date, little is known about the dermoscopic features of pigmented poromas.
  • METHODS: Twelve cases of pigmented poromas examined by dermoscopy at the Department of Dermatology, Shinshu University Hospital (Matsumoto, Japan), between January 2000 and February 2009 were collected.
  • CONCLUSIONS: Pigmented poromas mimic a number of skin tumors, including pigmented basal cell carcinomas, seborrheic keratosis and malignant melanoma, because they present various clinical, dermoscopic and histopathological features.
  • [MeSH-major] Dermoscopy. Pigmentation Disorders / diagnosis. Poroma / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratosis, Seborrheic / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Retrospective Studies. Skin Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516657.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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86. Fernandez MP, Wang NS, Terzakis JA, Meehan SA, Kamino H: Histopathology and X-ray microanalysis of foreign material on facial keratoses. Am J Dermatopathol; 2009 May;31(3):232-5
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  • [Title] Histopathology and X-ray microanalysis of foreign material on facial keratoses.
  • Opaque exogenous material was frequently observed on the surface of keratoses during routine sign out by one of us (H.K.).
  • To investigate this material further, 300 consecutive seborrheic keratoses were reviewed: 100 cases from the face of women, 100 cases from the face of men, and 100 cases from the trunk of men and women.
  • The material was present on 54% of facial keratoses from predominantly older women (mean age 67 years), 5% of facial keratoses from men, and 9% of truncal keratoses from men and women.
  • Further, because the exogenous material was found predominantly on facial keratoses of older women, the presence of this material in a specimen may serve as a clue to the patient's gender, age, and biopsy site.
  • [MeSH-major] Electron Probe Microanalysis. Facial Dermatoses / pathology. Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 19384063.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Ointments
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87. King R, Page RN, Googe PB, Mihm MC Jr: Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus. Mod Pathol; 2005 Oct;18(10):1397-401
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  • We present pigmented lesions from 16 patients (seven male and nine female) and with the exception of one case, all were older than 50 years of age.
  • The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo.
  • The diagnosis of melanoma was more easily recognized in the complete excision specimens.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Hutchinson's Melanotic Freckle / diagnosis. Lentigo / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15976811.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Zaballos P, Daufí C, Puig S, Argenziano G, Moreno-Ramírez D, Cabo H, Marghoob AA, Llambrich A, Zalaudek I, Malvehy J: Dermoscopy of solitary angiokeratomas: a morphological study. Arch Dermatol; 2007 Mar;143(3):318-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: There were 256 patients total, and 32 specimens each of solitary angiokeratomas, melanocytic nevi, Spitz-Reed nevi, malignant melanomas, pigmented basal cell carcinomas, dermatofibromas, seborrheic keratoses, and other vascular lesions (19 angiomas, 7 pyogenic granulomas, 3 spider nevi, 2 lymphangiomas, and 1 venous lake) were consecutively collected from the laboratories of 8 hospitals.
  • Dark lacunae exhibited a sensitivity of 93.8% and a specificity of 99.1% (P<.001 for both), not being found in malignant melanomas or pigmented basal cell carcinomas.
  • Pattern 1, consisting of dark lacunae and whitish veil, exhibited a sensitivity of 84.4% and a specificity of 99.1% and was not found in malignant melanomas or pigmented basal cell carcinomas.
  • Conclusion Dermoscopy is helpful in improving the diagnostic accuracy of solitary angiokeratomas and allows the observer to differentiate them from other cutaneous tumors such as malignant melanomas and pigmented basal cell carcinomas.

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  • (PMID = 17372096.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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89. Lally A, Casabonne D, Waterboer T, Imko-Walczuk B, Michael KM, Pawlita M, Newton R, Wojnarowska F: Association of seborrhoeic warts with skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):302-7
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  • [Title] Association of seborrhoeic warts with skin cancer in renal transplant recipients.
  • A clinical observation that RTR with skin cancer often had multiple seborrhoeic warts prompted an investigation in RTR into the relationship between seborrhoeic warts and skin cancer and an exploration into potential risk factors for seborrhoeic warts in this population, including infection with human papillomavirus (HPV).
  • Clinical examinations identified seborrhoeic warts.
  • Odds ratios (OR) calculated using unconditional logistic regression analysis to look for associations between skin cancer, HPV infection and seborrhoeic warts, controlling for potential confounding factors of gender, age and time since transplantation.
  • RESULTS: Seborrhoeic warts were associated with non-melanoma skin cancer [OR = 3.7; 95% confidence intervals (CI) ranging from 1.6-8.9; P = 0.002] when confounding factors of gender, age and time since transplantation were controlled for.
  • There was also an association between seborrhoeic warts and viral warts (OR = 3.0, CI: 1.6-5.4; P < 0.0001), but no association between seborrhoeic warts and infection with single or multiple HPV types.
  • CONCLUSIONS: Seborrhoeic warts are associated with cutaneous malignancy, but not with any of the HPV types tested.
  • RTR with multiple seborrhoeic warts may require more regular cutaneous examination to monitor for early signs of skin cancer.
  • [MeSH-major] Dermatitis, Seborrheic / complications. Kidney Transplantation / adverse effects. Skin Neoplasms / etiology. Warts / complications


90. Puizina-Ivić N, Sapunar D, Marasović D, Mirić L: An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. Coll Antropol; 2008 Oct;32 Suppl 2:61-5
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  • [Title] An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.
  • The Bcl-2 protein has been shown to suppress cell death and protects cell against apoptosis induced by different death-inducing signals.
  • In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK).
  • In cases of hypertrophic and atrophic variants of AK, Bcl-2 expression was confined to basal cell layer, as well as in one case of hypertrophic variant in suprabasal cells.
  • In morpheaform variant reduced amount of Bcl-2 expression indicated that this variant of BCC has increased cell proliferation, and in practice shows tendency for recurrence and difficulties to eradicate.
  • Bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis, Actinic / metabolism. Keratosis, Seborrheic / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism


91. Al-Daraji WI, Al-Dawoud A: Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association. Clin Exp Dermatol; 2005 Mar;30(2):137-40
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for cutaneous ganglioneuroma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association.
  • A 75-year-old woman presented to her general practitioner with a keratotic skin lesion on her abdomen.
  • Microscopic examination showed an irritated seborrheic keratosis.
  • Both the spindle cell component and the ganglion cells stained positively for S-100 protein, neurofilament protein and CD56 (Leu-19, NCAM) by routine immunohistochemistry.
  • We describe the second case of primary cutaneous ganglioneuroma associated with seborrheic keratosis.
  • [MeSH-major] Ganglioneuroma / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / complications

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  • (PMID = 15725239.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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92. Bursztejn AC, Doumat-Batch F, Granel-Brocard F, Perrin A, Cuny JF, Barbaud A, Schmutz JL: [Sézary syndrome and Leser-Trélat sign: a chance association?]. Ann Dermatol Venereol; 2008 Apr;135(4):287-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Syndrome de Sézary et syndrome de Leser-Trélat: association fortuite?
  • BACKGROUND: Leser-Trélat sign involves the combined sudden onset of seborrheic keratosis and cancer.
  • PATIENTS AND METHODS: A 59-year-old woman presented generalized pruritus with secondary appearance of multiple seborrheic keratosis.
  • Extracorporeal photopheresis was initiated, after which there was a marked reduction in the patient's pruritus, erythroderma and numbers of seborrheic keratoses and Sézary cells.
  • Rampen and Schwengle [J Am Acad Dermatol 21 (1989) 50-5] have thrown doubt on this entity because of the "subjective" definition, the frequent dissociation between the course of the tumour and that of the seborrheic keratosis, the disparity between the frequency with which rapid onset seborrheic keratosis is seen and the rarity of cases in which this phenomenon reveals a tumour and the absence of association with any specific type of malignancy.
  • The time between diagnosis of Sézary syndrome and cutaneous symptoms of Leser-Trélat sign appears very long in the present case.
  • [MeSH-major] Keratosis, Seborrheic / complications. Sezary Syndrome / complications. Skin Neoplasms / complications

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  • (PMID = 18420075.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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93. Steele CL, Shea CR, Petronic-Rosic V: Epidermolytic hyperkeratosis within infundibular cysts. J Cutan Pathol; 2007 Apr;34(4):360-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermolytic hyperkeratosis within infundibular cysts.
  • Epidermolytic hyperkeratosis (EH) is a well-described histopathologic pattern characteristic of bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis.
  • EH has been observed as an incidental finding in tissue adjacent to and within lesions such as nevi, scars, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and seborrheic keratoses.
  • We present two cases of EH within infundibular type follicular cysts, a rare finding only once otherwise reported in 1978.
  • [MeSH-major] Epidermal Cyst / complications. Epidermal Cyst / pathology. Hyperkeratosis, Epidermolytic / complications. Hyperkeratosis, Epidermolytic / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / complications. Carcinoma, Squamous Cell / complications. Female. Humans. Incidental Findings. Male. Skin Neoplasms / complications

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  • (PMID = 17381810.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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94. Inoue T, Kobayashi K, Sawada M, Ishizaki S, Ito H, Fujibayashi M, Tanaka M: Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma. Dermatol Res Pract; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma.
  • Various structures have been reported for dermoscopic features of pigmented Bowen's disease (BD), which could be a mimic of various pigmented skin lesions.
  • A 79-year-old Japanese woman presented with a 3-year history of brown-black macule on her right upper arm without symptom.
  • We suspected pigmented skin lesions including seborrheic keratosis, pigmented eccrine poroma, and malignant melanoma and excised completely with a 5 mm margin.
  • Histopathological features were consistent with a diagnosis of pigmented BD.
  • Although similar dermoscopic features might be revealed in pigmented skin lesions and it may occasionally be difficult to distinguish between pigmented BD and other pigmented skin lesions, dermoscopy would be useful in speculating pathologic features of pigmented BD.

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  • (PMID = 20811602.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2929512
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95. Molho-Pessach V, Agha Z, Aamar S, Glaser B, Doviner V, Hiller N, Zangen DH, Raas-Rothschild A, Ben-Neriah Z, Shweiki S, Elpeleg O, Zlotogorski A: The H syndrome: a genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin with systemic manifestations. J Am Acad Dermatol; 2008 Jul;59(1):79-85
SciCrunch. KEGG: Data: Disease Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The association of cutaneous hyperpigmented, hypertrichotic, and indurated patches associated with hearing loss, short stature, cardiac anomalies, hepatosplenomegaly, scrotal masses, and hypogonadism has not, to our knowledge, been previously recognized as a disease entity.
  • Cutaneous histopathologic examination showed hyperpigmentation of the basal layer with seborrheic-keratosis-like acanthosis, histiocytic infiltration, and a perivascular mononuclear infiltrate with plasma cells and mast cells throughout the dermis and subcutaneous fat.
  • CONCLUSIONS: We suggest that our patients represent a novel multisystemic autosomal recessive inherited disorder.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hyperpigmentation / diagnosis. Hypertrichosis / diagnosis. Skin Diseases, Genetic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy. Consanguinity. Female. Fibrosis. Genital Diseases, Male / diagnosis. Heart Defects, Congenital / diagnosis. Hepatomegaly / diagnosis. Humans. Lymph Nodes / pathology. Male. Phenotype. Skin / pathology. Splenomegaly / diagnosis. Syndrome

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  • [CommentIn] J Am Acad Dermatol. 2009 Oct;61(4):725-7 [19664849.001]
  • [CommentIn] J Am Acad Dermatol. 2009 Aug;61(2):365 [19615552.001]
  • (PMID = 18410979.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Choi HJ, Yun SK, Kim HU, Ihm CW: Squamous eddies in irritated seborrheic keratosis. Am J Dermatopathol; 2007 Feb;29(1):28-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous eddies in irritated seborrheic keratosis.
  • Seborrheic keratosis is related to the intraepidermal hair follicle in its morphogenesis.
  • Squamous eddies in irritated seborrheic keratosis (ISK) are known to develop by focal maturation of basaloid cells, but the significance of squamous eddies is not understood.
  • The purpose of this study was to elucidate the nature of squamous eddies in ISK.
  • Serial sections of paraffin blocks of 20 cases of ISK were examined.
  • In 13 cases, squamous eddies were connected to keratotic invaginations we thought to be follicular infundibula.
  • Eighteen of the 20 cases of ISK showed at least 1 of the morphological features of intraepidermal hair follicle structures.
  • We have found that the squamous eddies of ISK are anatomically related to acrotrichia.
  • [MeSH-major] Epithelial Cells / pathology. Keratosis, Seborrheic / pathology. Skin / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Hair Follicle / pathology. Humans. Male. Middle Aged

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  • [ErratumIn] Am J Dermatopathol. 2007 Apr;29(2):229. Choi, Hye-Ja [added]; Yun, Seok-Kweon [added]; Kim, Han-U K [added]
  • (PMID = 17284959.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Peterson J, Shook BA, Wells MJ, Rodriguez M: Cupric keratosis: green seborrheic keratoses secondary to external copper exposure. Cutis; 2006 Jan;77(1):39-41
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cupric keratosis: green seborrheic keratoses secondary to external copper exposure.
  • We report the case of a patient with a blue-green discoloration of multiple seborrheic keratoses on his chest and back after swimming in a pool for rehabilitation of a back injury.
  • After the patient discontinued water exercises in the swimming pool, the green discoloration of the seborrheic keratoses disappeared rapidly.
  • [MeSH-major] Copper / adverse effects. Environmental Exposure / adverse effects. Keratosis, Seborrheic / etiology. Trace Elements / adverse effects

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  • Hazardous Substances Data Bank. COPPER, ELEMENTAL .
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  • (PMID = 16475494.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Trace Elements; 059QF0KO0R / Water; 789U1901C5 / Copper
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98. Terada T: Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. Int J Clin Oncol; 2010 Dec;15(6):608-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis.
  • A 76-year-old man consulted to our hospital complaining of a black tumor of the temporal head.
  • A clinical diagnosis of basal cell carcinoma was made, and an excision with wide margins was performed.
  • The cells were heavily pigmented.
  • The periphery of the tumor showed typical features of pigmented reticulated seborrheic keratosis.
  • This case suggests that pigmented Bowen disease can arise in pigmented reticulated seborrheic keratosis.
  • [MeSH-major] Bowen's Disease / etiology. Carcinoma, Basal Cell / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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  • (PMID = 20425131.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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99. Burkhart CG, Burkhart CN: Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses. Skinmed; 2008 Jan-Feb;7(1):15-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses.
  • BACKGROUND: Seborrheic keratoses are the most common benign tumors in adults.
  • METHODS: A topical 50% urea-containing product under occlusion was applied daily to large and/or thick hyperkeratotic seborrheic keratoses on the truck and extremities.
  • CONCLUSIONS: Hyperkeratotic seborrheic keratoses can be satisfactorily managed with topical agents and scraping with reasonable patient satisfaction.
  • [MeSH-major] Keratolytic Agents / administration & dosage. Keratosis, Seborrheic / drug therapy. Occlusive Dressings

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  • (PMID = 18174808.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratolytic Agents
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100. Keskin EA, Gorpelioglu C, Sarifakioglu E, Kafali H: Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report. Cases J; 2010;3:56

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report.
  • Seborrheic keratoses, a benign growth lesion, is a very common cutaneous lesion encountered in white races in the fourth and fifth decade.
  • A 34-year-old woman reported with a hyperpigmented palpable lesion, approximately 5-10 mm in diameter, was found on the patient's left labium majus.
  • The clinical differential diagnosis of the pigmented lesions of the vulva is difficult often need a biopsy.

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  • [Cites] Dermatol Clin. 1992 Apr;10(2):361-70 [1606765.001]
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  • (PMID = 20181151.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2834621
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