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1. Staal-Viliare A, Latger-Cannard V, Rault JP, Didion J, Grégoire MJ, Bologna S, Witz B, Jonveaux P, Lecompte T, Rio Y: [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature]. Ann Biol Clin (Paris); 2006 Jul-Aug;64(4):361-5
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  • [Title] [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature].
  • [Transliterated title] A propos d'un cas de leucémie à basophiles de novo: critères diagnostiques et revue de la littérature.
  • We report a case of a de novo acute basophilic leukaemia, revealed by an infectious pneumopathy in a 73 year old man.
  • The blood and bone marrow smears showed a mixture of undifferentiated blast cells and basophiloblasts (high nucleo-cytoplasmic ratio, coarse basophilic cytoplasmic granules), along with basophilic precursors and basophilic polymorphonuclears.
  • All the blasts were MPO negative but positive for the toluidine blue metachromatic coloration, which is considered as consistent with basophilic lineage.
  • Immunophenotypic studies showed myeloid blasts, without maturity marker, CD 117 negative and CD203 cytoplasmic positive, the latter known to be highly representative of the basophilic lineage.
  • This very clear-cut phenotype, associated with the morphology of cells, were arguments to ascertain the basophilic lineage of the blasts without the need of electron microscopic study.
  • This clinical prompted allows us to review the literature on acute basophilic leukaemia and to state on the different diagnostic criteria of this rare disorder.
  • [MeSH-major] Leukemia, Basophilic, Acute / blood. Leukemia, Basophilic, Acute / diagnosis

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  • (PMID = 16829481.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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2. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7

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  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Line, Tumor. Humans. Intestines / microbiology. Lactobacillus / physiology. Rats. Signal Transduction

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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3. Kato N, Nakanishi M, Hirashima N: Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J Immunol; 2006 Jul 1;177(1):147-54
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  • [Title] Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
  • Cross-linking of high-affinity IgE receptors by multivalent Ag on mast cells (rat basophilic leukemia (RBL)-2H3) induces the phosphorylation of ITAM motifs of an IgE receptor by Src family tyrosine kinase, Lyn.
  • We obtained flotillin-1 knockdown (KD)(2) rat basophilic leukemia (RBL)-2H3 cells, which express a low level of flotillin-1.
  • [MeSH-minor] Animals. Calcium / metabolism. Calcium Signaling / physiology. Cell Degranulation / physiology. Cell Line, Tumor. Enzyme Activation / physiology. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / enzymology. Membrane Microdomains / immunology. Membrane Microdomains / metabolism. Phosphorylation. Rats. Transfection. Tyrosine / metabolism. src-Family Kinases / metabolism

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  • (PMID = 16785509.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE; 0 / flotillins; 42HK56048U / Tyrosine; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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4. Blonski WC, Katzka DA, Lichtenstein GR, Metz DC: Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Apr;17(4):441-4
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  • [Title] Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease.
  • Many gastric acid hypersecretory states (basal acid output of greater than 15.0 mEq/h) exist for which the etiology is known, such as Zollinger-Ellison syndrome, systemic mastocytosis, antral exclusion, antral predominant Helicobacter pylori gastritis (antral G cell hyperplasia), chronic gastric outlet obstruction, short gut syndrome and basophilic leukemias.

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Dec;17(12):1433 [16292103.001]
  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Sep;17(9):1001 [16093882.001]
  • (PMID = 15756097.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Gastrins; KG60484QX9 / Omeprazole
  • [Number-of-references] 28
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5. Zhang Y, Yu MH, Xu SC, Yang L, Yu Y, Hao YS, Xiao ZJ: [Studying of clinical and laboratory features of chronic eosinophilic leukemias /hypereosinophilic syndrome]. Zhonghua Xue Ye Xue Za Zhi; 2008 Jan;29(1):3-8
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  • [Title] [Studying of clinical and laboratory features of chronic eosinophilic leukemias /hypereosinophilic syndrome].
  • OBJECTIVE: To investigate the clinical and laboratory features of chronic eosinophilic leukemias (CEL) and hypereosinophilic syndrome (HES).
  • The morphological abnormalities of eosinophils on bone marrow smear were easily found in CEL, including hypogranularity, and cytoplasmic vacuolization, increased basophilic granule.

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  • (PMID = 18512307.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / FIP1L1 protein, human; 0 / mRNA Cleavage and Polyadenylation Factors; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.2 / Janus Kinase 2
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6. Huelsenbeck SC, Klose I, Reichenbach M, Huelsenbeck J, Genth H: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. FEBS Lett; 2009 Oct 6;583(19):3133-9
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  • Alternative Ras antibodies including the K-Ras(Mab F234) antibody or the v-H-Ras(Mab Y13-159) antibody recognize Ras proteins regardless of glucosylation. (H/K)Ras are further shown to be more efficaciously glucosylated by TcsL than Rac1 in rat basophilic leukemia cells as well as in a cell-free system.

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  • (PMID = 19744486.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / lethal toxin LT, Clostridium sordellii; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / ras Proteins
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7. Mizuno H, Tsuyama N, Date S, Harada T, Masujima T: Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell. Anal Sci; 2008 Dec;24(12):1525-7
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  • [Title] Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell.
  • The metabolic pathways and the locations of tryptophan and histidine metabolites were traced by this method for a cultured rat basophil leukemia cell line (RBL-2H3).
  • [MeSH-major] Basophils / metabolism. Basophils / pathology. Histidine / metabolism. Leukemia / metabolism. Leukemia / pathology. Metabolomics. Tryptophan / metabolism

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  • (PMID = 19075459.001).
  • [ISSN] 1348-2246
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 4QD397987E / Histidine; 8DUH1N11BX / Tryptophan
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8. Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M: Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells. Biol Pharm Bull; 2007 Mar;30(3):443-6
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  • [Title] Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.
  • To trigger degranulation, rat basophilic leukemia (RBL)-2H3 cells were passively sensitized using an antiserum collected from ovalbumin (OA) immunized-Brown Norway rats, and the cells were stimulated by treatment with OA.
  • [MeSH-major] Cell Degranulation. Heme Oxygenase-1 / metabolism. Leukemia, Basophilic, Acute / metabolism

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  • (PMID = 17329835.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 2',7'-dichlorodihydrofluorescein diacetate; 0 / Azo Compounds; 0 / Enzyme Inhibitors; 0 / Fluoresceins; 0 / Free Radical Scavengers; 0 / Metalloporphyrins; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0KAE1U0G7Q / tin mesoporphyrin; 6226-79-5 / ponceau S; 9006-59-1 / Ovalbumin; EC 1.14.99.3 / Heme Oxygenase-1; WYQ7N0BPYC / Acetylcysteine
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9. Wu Y, Slovak ML, Snyder DS, Arber DA: Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature. Am J Clin Pathol; 2006 Feb;125(2):260-6
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  • [Title] Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature.
  • We report 5 cases of chronic myelogenous leukemia (CML) and 1 case of acute myeloid leukemia (AML) with the dual presence of t(9;22) and inv(16).
  • The CBFbeta-MYH11 fusion gene was confirmed in all 3 CML cases and the 1 AML case tested, and this correlated with the presence of abnormal eosinophils with coarse basophilic granules.
  • [MeSH-major] Chromosome Inversion. Chromosomes, Human, Pair 16. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Acute / genetics. Philadelphia Chromosome

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  • (PMID = 16393682.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBFB protein, human; 0 / Core Binding Factor beta Subunit; 0 / Recombinant Fusion Proteins; EC 3.6.4.1 / Myosin Heavy Chains
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10. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Bioorg Med Chem; 2008 Aug 15;16(16):7592-8
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  • [Title] Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
  • It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Calcium / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Histamine Release / drug effects. Immunoblotting. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia, Basophilic, Acute. Phospholipase C gamma / antagonists & inhibitors. Phospholipase C gamma / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Receptors, IgG / metabolism. Signal Transduction / drug effects. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 18656366.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Flavones; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgG; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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11. Itoh T, Ninomiya M, Nozawa Y, Koketsu M: Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem; 2010 Oct 1;18(19):7052-7
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  • [Title] Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
  • We isolated three chalcone glycosides along with other glycoside constituents from the aerial parts of Brassica rapa L. 'hidabeni' and examined the effects of these compounds on the antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20801664.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Biphenyl Compounds; 0 / Chalcones; 0 / Free Radical Scavengers; 0 / Glycosides; 0 / Picrates; 0 / Plant Extracts; 0 / Reactive Oxygen Species; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl; EC 1.6.3.1 / NADPH Oxidase
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12. Barth EE, Hallworth R, Nichols MG: A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells. Photochem Photobiol; 2005 May-Jun;81(3):556-62
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  • [Title] A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells.
  • Photodamage was induced in rat basophilic leukemia cells by either 254-nm UVC light exposure or rose bengal photosensitization.
  • [MeSH-major] Cell Division / radiation effects. Leukemia / pathology. Rose Bengal / toxicity. Ultraviolet Rays / adverse effects

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  • (PMID = 15773792.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Photosensitizing Agents; 1N3CZ14C5O / Rhodamine 123; 1ZPG1ELY14 / Rose Bengal; 36015-30-2 / Propidium; EC 3.1.- / Esterases; G34N38R2N1 / Bromodeoxyuridine; V0YM2B16TS / fluorexon
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13. Moser AM, Manor E, Narkis G, Kapelushnik J: Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. Cancer Genet Cytogenet; 2006 Oct 1;170(1):54-7
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  • [Title] Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up.
  • The case of an 11-year-old child with adult-type chronic myeloid leukemia, Philadelphia (BCR-ABL) positive, reverse transcription-polymerase chain reaction negative for the major, minor, and micro breakpoints is presented.
  • In the course of 3 years, the child failed to respond to treatment with hydroxyurea, refused all therapy for 6 months, was intolerant to alpha-interferon and progressed, while on imatinib, to acute basophilic leukemia.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Genes, abl. Leukemia, Basophilic, Acute / surgery. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 16965955.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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14. Lichtman MA, Segel GB: Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review. Blood Cells Mol Dis; 2005 Nov-Dec;35(3):370-83
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  • [Title] Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.
  • The potential of the transformed (leukemic) multipotential hematopoietic cell to differentiate and mature along any myeloid lineage forms the basis for the phenotypic classification of acute and chronic myelogenous leukemia.
  • Although most cases of leukemia can be classified phenotypically by the dominant lineage expressed, the genotype within each phenotype is heterogeneous.
  • The least common AML phenotypes are a reflection of the least common blood or marrow cell lineages: acute basophilic, acute mast cell, acute eosinophilic, and acute myeloid dendritic cell leukemia.
  • [MeSH-major] Basophils / pathology. Dendritic Cells / pathology. Eosinophils / pathology. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Acute / pathology. Mast Cells / pathology. Myeloid Cells / pathology


15. Pidala J, Pinilla-Ibarz J, Cualing HD: A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet; 2008 Apr 1;182(1):46-9
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  • [Title] A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies.
  • A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • [MeSH-major] Chromosomes, Human, Pair 7. Chromosomes, Human, Pair 8. Leukemia, Basophilic, Acute / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Translocation, Genetic


16. Källquist L, Rosén H, Nordenfelt P, Calafat J, Janssen H, Persson AM, Hansson M, Olsson I: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. Exp Cell Res; 2010 Nov 15;316(19):3182-96
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  • The NE aminoacid residue Y199 of a proposed NE sorting motif that interacts with AP-3 [2] was not required for proNE processing, sorting or endocytosis in rat basophilic leukemia (RBL) cells expressing heterologous Y199-deleted proNE; this suggests operation of another AP-3-link for proNE targeting.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20828556.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex 3; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / CD63 protein, human; 0 / Cd63 protein, rat; 0 / Enzyme Precursors; 0 / Platelet Membrane Glycoproteins; 42HK56048U / Tyrosine; EC 3.4.21.37 / Leukocyte Elastase; EC 3.4.21.76 / Myeloblastin; EC 5.2.1.- / Tacrolimus Binding Proteins
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17. Nakamura R, Nakamura R, Watanabe K, Oka K, Ohta S, Mishima S, Teshima R: Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis. Int Immunopharmacol; 2010 Sep;10(9):1107-12
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  • The amount of released beta-hexosaminidase via high-affinity IgE receptor I (Fc epsilon RI) from rat basophilic leukemia (RBL-2H3) cells was used as an index of degranulation.

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  • [Copyright] (c) 2010 Elsevier B.V. All rights reserved.
  • [CommentIn] Int Immunopharmacol. 2011 Sep;11(9):1386-7 [21481329.001]
  • (PMID = 20601180.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Chemokine CCL2; 0 / Cytokines; 0 / Flavonoids; 0 / Kaempferols; 0 / Plant Extracts; 0 / Receptors, IgE; 207137-56-2 / Interleukin-4; 3CN01F5ZJ5 / chrysin; 731P2LE49E / kaempferol; 9009-62-5 / Propolis; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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18. Sakai S, Sugawara T, Matsubara K, Hirata T: Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors. J Biol Chem; 2009 Oct 9;284(41):28172-9
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  • Fucoxanthin, astaxanthin, zeaxanthin, and beta-carotene significantly inhibited the antigen-induced release of beta-hexosaminidase in rat basophilic leukemia 2H3 cells and mouse bone marrow-derived mast cells.

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  • (PMID = 19700409.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Monoterpenes; 0 / Receptors, IgE; 36-88-4 / Carotenoids; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
  • [Other-IDs] NLM/ PMC2788868
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19. Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T: Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res; 2009 Oct;58(10):705-15
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  • OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells.
  • [MeSH-minor] Animals. Bilirubin / pharmacology. Carbon Monoxide / pharmacology. Cells, Cultured. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Heme Oxygenase (Decyclizing) / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Metalloporphyrins / pharmacology. Mice. Mice, Inbred BALB C. NF-E2-Related Factor 2 / metabolism. Protoporphyrins / pharmacology. Rats. Rats, Wistar

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  • (PMID = 19390785.001).
  • [ISSN] 1420-908X
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Metalloporphyrins; 0 / NF-E2-Related Factor 2; 0 / Protoporphyrins; 14325-05-4 / tin protoporphyrin IX; 7U1EE4V452 / Carbon Monoxide; 9IKM0I5T1E / Quercetin; EC 1.14.14.18 / Heme Oxygenase (Decyclizing); EC 1.14.14.18 / Heme Oxygenase-1; EC 1.14.14.18 / heme oxygenase-2; RFM9X3LJ49 / Bilirubin
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20. Shaik GM, Dráberová L, Heneberg P, Dráber P: Vacuolin-1-modulated exocytosis and cell resealing in mast cells. Cell Signal; 2009 Aug;21(8):1337-45
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  • Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis.

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  • (PMID = 19376224.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Heterocyclic Compounds with 4 or More Rings; 0 / Receptors, IgE; 0 / vacuolin-1; SY7Q814VUP / Calcium
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21. Nowak-Wegrzyn AH, Bencharitiwong R, Schwarz J, David G, Eggleston P, Gergen PJ, Liu AH, Pongracic JA, Sarpong S, Sampson HA: Mediator release assay for assessment of biological potency of German cockroach allergen extracts. J Allergy Clin Immunol; 2009 Apr;123(4):949-955.e1
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  • OBJECTIVE: We investigated the utility of a mediator release assay based on rat basophil leukemia (RBL) cells for comparing the potency of German cockroach extracts.

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  • (PMID = 19348929.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / K23 AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25482; United States / NIAID NIH HHS / AI / N01 AI025496; United States / NIAID NIH HHS / AI / AI 059318; United States / NIAID NIH HHS / AI / N01AI25496; United States / NIAID NIH HHS / AI / N01 AI025482; United States / NIAID NIH HHS / AI / K23 AI059318; United States / NIAID NIH HHS / AI / N01AI25482; United States / NIAID NIH HHS / AI / AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25496
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 3.2.1.- / Hexosaminidases
  • [Other-IDs] NLM/ NIHMS109184; NLM/ PMC2952833
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22. Sun J, Wu Y, Wang J, Ma F, Liu X, Li Q: Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica. Biochimie; 2008 Nov-Dec;90(11-12):1760-8

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  • It mediated histamine release from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 18822340.001).
  • [ISSN] 1638-6183
  • [Journal-full-title] Biochimie
  • [ISO-abbreviation] Biochimie
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Recombinant Proteins; 0 / tumor protein, translationally-controlled 1
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23. Ryu H, Walker JK, Kim S, Koo N, Barak LS, Noguchi T, Kang BY, Kim KM: Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. Br J Pharmacol; 2008 Jul;154(5):1035-46
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  • EXPERIMENTAL APPROACH: In rat basophilic leukaemia (RBL-2H3) cells, the effects of directly inhibiting M2PK or preventing the FcvarepsilonRI-mediated inhibition of M2PK (disinhibition) on degranulation was measured by hexosaminidase release.

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  • (PMID = 18587448.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Receptors, IgE; 9006-59-1 / Ovalbumin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.40 / Pyruvate Kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.13 / Protein Kinase C; EC 3.2.1.- / Hexosaminidases; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2451040
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24. Wagner S, Radauer C, Bublin M, Hoffmann-Sommergruber K, Kopp T, Greisenegger EK, Vogel L, Vieths S, Scheiner O, Breiteneder H: Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol; 2008 Jan;121(1):246-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Isoform structures were compared and related to IgE-binding inhibitory capacities and induction of mediator release in human Fcvarepsilon receptor transformed rat basophilic leukemia cells.

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  • (PMID = 17889932.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Blocking; 0 / Antigens, Plant; 0 / Immunoglobulin G; 0 / Plant Proteins; 0 / Protein Isoforms; 126161-14-6 / Bet v 1 allergen, Betula; 37341-29-0 / Immunoglobulin E
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25. Thors L, Eriksson J, Fowler CJ: Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake. Br J Pharmacol; 2007 Nov;152(5):744-50
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  • BACKGROUND AND PURPOSE: Genistein, a tyrosine kinase inhibitor used to block caveolae dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 17676056.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / DA009789-12A17961; United States / NIDA NIH HHS / DA / P01 DA009789; United States / NIDA NIH HHS / DA / P01 DA009789-12A17961
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Isoflavones; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 10028-17-8 / Tritium; 6287WC5J2L / daidzein; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2190009
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26. Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H: Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med; 2007 Jun;73(7):662-5
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  • Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187.

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  • (PMID = 17538871.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Plant Extracts
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27. Teshima R, Amano F, Nakamura R, Tanaka Y, Sawada J: Effects of polyunsaturated fatty acids on calcium response and degranulation from RBL-2H3 cells. Int Immunopharmacol; 2007 Feb;7(2):205-10
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  • To investigate the biological activity of various polyunsaturated fatty acids (PUFAs) on the allergic reaction, we examined the effects of six PUFAs and two saturated fatty acids on calcium response and degranulation from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17178388.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Fatty Acids, Unsaturated; 85166-31-0 / Inositol 1,4,5-Trisphosphate; SY7Q814VUP / Calcium
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28. Chikamatsu S, Furuno T, Kinoshita Y, Inoh Y, Hirashima N, Teshima R, Nakanishi M: Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Mol Immunol; 2007 Mar;44(7):1490-7
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  • Here we have shown that Cot kinase activity is intimately involved in the high affinity receptor for IgE (FcvarepsilonRI)-mediated nuclear translocation of NF-kappaB1 independent of NF-kappaB-inducing kinase (NIK) in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17049604.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Luminescent Proteins; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / red fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.11.25 / MAP Kinase Kinase Kinases; EC 2.7.11.25 / Map3k8 protein, rat
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29. Buku A, Condie BA, Price JA, Mezei M: [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors. J Pept Res; 2005 Sep;66(3):132-7
Hazardous Substances Data Bank. (L)-ALANINE .

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  • In contrast to MCD peptide, [Ala12]MCD showed a 50% inhibition of IgE binding to the Fc epsilon RI alpha mast cell receptor by using rat basophilic leukemia (RBL-2H3) mast cells and fluorescence polarization.

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  • (PMID = 16083440.001).
  • [ISSN] 1397-002X
  • [Journal-full-title] The journal of peptide research : official journal of the American Peptide Society
  • [ISO-abbreviation] J. Pept. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Peptides; 0 / Receptors, Cell Surface; 32908-73-9 / mast cell degranulating peptide; 37341-29-0 / Immunoglobulin E; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; OF5P57N2ZX / Alanine
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30. Avril T, Freeman SD, Attrill H, Clarke RG, Crocker PR: Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem; 2005 May 20;280(20):19843-51
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  • To investigate the role of these motifs in Siglec-5-dependent signaling, we used transfected rat basophil leukemia cells as a model system.

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  • (PMID = 15769739.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Intracellular Signaling Peptides and Proteins; 0 / Lectins; 0 / Recombinant Fusion Proteins; 0 / SIGLEC5 protein, human; 42HK56048U / Tyrosine; 9007-49-2 / DNA; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / PTPN6 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Ptpn11 protein, rat; EC 3.1.3.48 / Ptpn6 protein, rat
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31. Yamaki K, Yoshino S: Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. Environ Toxicol Pharmacol; 2010 Mar;29(2):183-9

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  • [Title] Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.
  • The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 21787600.001).
  • [ISSN] 1872-7077
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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32. Yanase Y, Hiragun T, Kaneko S, Gould HJ, Greaves MW, Hide M: Detection of refractive index changes in individual living cells by means of surface plasmon resonance imaging. Biosens Bioelectron; 2010 Oct 15;26(2):674-81

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  • The SPRI sensor could detect reactions of individual rat basophilic leukemia (RBL-2H3) cells, mouse keratinocyte (PAM212) cells, and human epidermal carcinoma (A431) cells in response to either specific or non-specific stimuli, such as antigen, phorbol ester or epidermal growth factor, with or without their inhibitors, resembling signals obtained by a conventional SPR sensor.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673712.001).
  • [ISSN] 1873-4235
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0501494
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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33. Ferreres F, Pereira DM, Gil-Izquierdo A, Valentão P, Botelho J, Mouga T, Andrade PB: HPLC-PAD-atmospheric pressure chemical ionization-MS metabolite profiling of cytotoxic carotenoids from the echinoderm Marthasterias glacialis (spiny sea-star). J Sep Sci; 2010 Aug;33(15):2250-7
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  • The purified carotenoid fraction displayed a strong cell proliferation inhibition against rat basophilic leukemia RBL-2H3 (IC(25)=268 microg/mL) cancer cell line.

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  • (PMID = 20574958.001).
  • [ISSN] 1615-9314
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 36-88-4 / Carotenoids
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34. Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T: Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol; 2010 Jul;10(7):769-76
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  • We examined the effects of Lico A and related chalcones on degranulation in a rat basophilic leukemia cell line, RBL-2H3.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399908.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Chalcones; 42HK56048U / Tyrosine; 58749-22-7 / licochalcone A; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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35. Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H: Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Planta Med; 2010 Oct;76(14):1512-8
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

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  • Wight on the basophilic cell-mediated allergic reaction.
  • The effect of acteoside on β-hexosaminidase release and intracellular [Ca (2+)] I level from rat basophilic leukemia (RBL-2H3) cells was determined.
  • Also, ELISA was used to determine the level of histamine, tumor necrosis factor (TNF)- α, and interleukin (IL)-4 on human basophilic (KU812) cells.
  • The effect of acteoside on basophilic cell viability was determined using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay.
  • Our findings provide evidence that acteoside inhibits basophilic cell-derived immediate-type and delayed-type allergic reactions.
  • This is the first report describing antiallergic activity of acteoside extracted from CISTANCHE TUBULOSA on basophilic cells.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20354949.001).
  • [ISSN] 1439-0221
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Catechols; 0 / Glucosides; 0 / Glycosides; 0 / IL4 protein, human; 0 / Phenols; 0 / Tumor Necrosis Factor-alpha; 0 / cistanoside A; 207137-56-2 / Interleukin-4; 37H9VM9WZL / Calcimycin; 61276-17-3 / acteoside; 820484N8I3 / Histamine; 82854-37-3 / echinacoside; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; NI40JAQ945 / Tetradecanoylphorbol Acetate; SY7Q814VUP / Calcium
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36. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y: Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol; 2010 Sep;32(3):454-61
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  • To investigate the antiallergic effects of fermented grape marc from Negroamaro (N-FGM), we examined antigen (Ag)-induced degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Antigens / immunology. Basophil Degranulation Test. Fermentation. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein-Tyrosine Kinases / metabolism. Rats. Syk Kinase. Tumor Cells, Cultured

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  • (PMID = 20100066.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D008123/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 37341-29-0 / Immunoglobulin E; 9IKM0I5T1E / Quercetin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Syk Kinase; EC 2.7.10.2 / Syk protein, rat
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37. Gadermaier G, Jahn-Schmid B, Vogel L, Egger M, Himly M, Briza P, Ebner C, Vieths S, Bohle B, Ferreira F: Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol; 2010 Mar;47(6):1292-8
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  • Mediator release assays using rat basophil leukemia cells showed that these variants displayed a 1x10(5)-fold reduced allergenic potency as compared to wild-type protein.

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  • (PMID = 20022115.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 20011
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies; 0 / Antigens, Plant; 0 / Art v 1 protein, mugwort; 0 / Mutant Proteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; K848JZ4886 / Cysteine
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38. Cohen R, Torres A, Ma HT, Holowka D, Baird B: Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells. J Immunol; 2009 Nov 15;183(10):6478-88
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  • Using single cell stimulation by IgE-specific Ag and high-speed imaging of conventional or genetically encoded Ca(2+) sensors in rat basophilic leukemia and bone marrow-derived rat mast cells, we observe Ca(2+) waves that originate most frequently from the tips of extended cell protrusions, as well as Ca(2+) oscillations throughout the cell that usually follow the initiating Ca(2+) wave.
  • Initiating Ca(2+) waves are observed in most rat basophilic leukemia cells stimulated with soluble Ag and are sensitive to inhibitors of Ca(2+) release from endoplasmic reticulum stores and to extracellular Ca(2+), but they do not depend on store-operated Ca(2+) entry.

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  • (PMID = 19864608.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / R01 AI022449-23; United States / NIAID NIH HHS / AI / AI022449
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Estrenes; 0 / Phosphodiesterase Inhibitors; 0 / Pyrrolidinones; 0 / TRPC Cation Channels; 0 / TRPC3 cation channel; 0 / transient receptor potential cation channel, subfamily C, member 1; 112648-68-7 / 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 37341-29-0 / Immunoglobulin E; I9ZF7L6G2L / Nifedipine; NGZ37HRE42 / Sphingosine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS265600; NLM/ PMC3037335
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39. Schulmeister U, Hochwallner H, Swoboda I, Focke-Tejkl M, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Keller W, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, Valenta R, Spitzauer S: Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen. J Immunol; 2009 Jun 1;182(11):7019-29
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  • The allergenic activity of ralphaS1-casein and the alphaS1-casein-derived peptides was determined using rat basophil leukemia cells transfected with human FcepsilonRI, which had been loaded with the patients' serum IgE.
  • Our results demonstrate that ralphaS1-casein as well as alphaS1-casein-derived peptides exhibit IgE reactivity, but mainly the intact ralphaS1-casein induced strong basophil degranulation.

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  • (PMID = 19454699.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / DNA, Complementary; 0 / Epitopes; 0 / Peptide Fragments; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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40. Lim H, Son KH, Bae KH, Hung TM, Kim YS, Kim HP: 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. Phytother Res; 2009 Oct;23(10):1489-92
Hazardous Substances Data Bank. NITRIC OXIDE .

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  • The compounds including schizandrins, schisandrols, gomisins, fargesin, eudesmin and lirioresinol B dimethyl ether, inhibited 5-LOX-catalysed leukotriene production from A23187-treated rat basophilic leukemia (RBL-1) cells at concentrations of 1-100 microm.

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  • [Copyright] (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19277963.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Cyclooctanes; 0 / Leukotrienes; 0 / Lignans; 0 / Lipoxygenase Inhibitors; 0 / Plant Extracts; 0 / schisandrol A; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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41. Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C: A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem; 2009 Mar 27;284(13):8421-6
The Lens. Cited by Patents in .

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  • Expressing OASF in rat basophilic leukemia (RBL) mast cells demonstrated its enhanced plasma membrane targeting associated with 2.5-fold larger CRAC currents in comparison with the complete STIM1 C terminus.

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  • (PMID = 19189966.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ P18169/ P18280/ P21118
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / Orai1 protein, rat; 0 / STIM1 protein, human; 0 / Stim1 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2659200
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42. Torres AJ, Vasudevan L, Holowka D, Baird BA: Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays. Proc Natl Acad Sci U S A; 2008 Nov 11;105(45):17238-44
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • Patterned surfaces that present specific ligands in spatially defined arrays are used to examine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.
  • Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the patterned regions occupied by the ligands and associates preferentially with exposed regions of the silicon substrate.

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  • (PMID = 19004813.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI018306; United States / NIAID NIH HHS / AI / AI18306
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Ligands; 0 / Paxillin; 0 / RNA, Small Interfering; 0 / Receptors, IgE; 0 / Talin; 125361-02-6 / Vinculin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2582307
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43. Jensen BM, Swindle EJ, Iwaki S, Gilfillan AM: Generation, isolation, and maintenance of rodent mast cells and mast cell lines. Curr Protoc Immunol; 2006 Sep;Chapter 3:Unit 3.23
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  • In addition to human mast cells, the major cell culture systems employed to investigate these responses are rat and mouse peritoneal mast cells, mouse bone-marrow-derived mast cells, the rat basophilic leukemia cell line RBL-2H3, and the mouse MC/9 mast cell line.

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  • (PMID = 18432974.001).
  • [ISSN] 1934-368X
  • [Journal-full-title] Current protocols in immunology
  • [ISO-abbreviation] Curr Protoc Immunol
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / ZIA AI000965-04; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
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44. Leung WH, Bolland S: The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol; 2007 Jul 1;179(1):95-102
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  • Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 interacts with the FcepsilonRI beta-chain, Gab2 and Lyn and that unlike SHIP-1, it does not associate with SHC in mast cells.


45. Lessmann E, Leitges M, Huber M: A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol; 2006 May;18(5):767-73
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  • A critical role of PKC-epsilon in antigen-triggered activation of various signaling pathways was observed in basophilic leukemia cells.


46. Rettig JR, Folch A: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem; 2005 Sep 1;77(17):5628-34
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  • We have characterized microwell occupancy by cells for a range of microwell dimensions and seeding parameters and optimized it for fibroblasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cell).

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  • (PMID = 16131075.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R21DC006465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Chen BH, Wu PY, Chen KM, Fu TF, Wang HM, Chen CY: Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod; 2009 May 22;72(5):950-3
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  • In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically.

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  • (PMID = 19271742.001).
  • [ISSN] 1520-6025
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Phenols
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48. Suzuki R, Furuno T, Okamoto K, Teshima R, Nakanishi M: ATP plays a role in neurite stimulation with activated mast cells. J Neuroimmunol; 2007 Dec;192(1-2):49-56
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  • Addition of antigen to the cocultures of superior cervical ganglia (SCG) and rat basophilic leukemia cells (RBLs) elicited Ca(2+) response in RBLs and after a lag period induced Ca(2+) signal in SCG neurites.

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  • (PMID = 17928071.001).
  • [ISSN] 0165-5728
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dinitrophenols; 0 / Receptors, Cell Surface; 0 / Serum Albumin, Bovine; 0 / dinitrophenyl-bovine serum albumin; 333DO1RDJY / Serotonin; 820484N8I3 / Histamine; 8L70Q75FXE / Adenosine Triphosphate; SY7Q814VUP / Calcium
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49. Lippert U, Ferrari DM, Jahn R: Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells. FEBS Lett; 2007 Jul 24;581(18):3479-84
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  • [Title] Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells.
  • We used permeabilized rat basophilic leukaemia cells as model to identify R-SNAREs (soluble NSF (N-ethylmaleimide-sensitive fusion protein)) mediating exocytosis of hexosaminidase from mast cells.
  • [MeSH-major] Basophils / metabolism. Exocytosis. Hexosaminidases / metabolism. Hexosaminidases / secretion. Leukemia / metabolism. R-SNARE Proteins / metabolism

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  • (PMID = 17618625.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / R-SNARE Proteins; 0 / Streptolysins; 0 / Vamp8 protein, rat; 0 / Vesicle-Associated Membrane Protein 2; 0 / Vesicle-Associated Membrane Protein 3; 0 / streptolysin O; EC 3.2.1.- / Hexosaminidases; SY7Q814VUP / Calcium
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50. Qu X, Li Y, Liu J, Xu L, Zhang Y, Hu X, Hou K, Liu Y: Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Mol Cell Biochem; 2010 Jul;340(1-2):107-14
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  • [Title] Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents, Phytogenic / pharmacology. Apoptosis / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Mitogen-Activated Protein Kinase Kinases / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-cbl / metabolism

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  • (PMID = 20177738.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Enzyme Inhibitors; 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 6.3.2.- / Proto-Oncogene Proteins c-cbl; EC 6.3.2.19 / Cblb protein, rat
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51. Liao BC, Hou RC, Wang JS, Jeng KC: Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells. J Biomed Sci; 2006 Sep;13(5):613-9
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  • [Title] Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells.
  • In this study, SP and dinitrophenyl-bovine serum albumin (DNP-BSA) were used to activate rat basophilic leukemia (RBL)-2H3 cells.

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  • (PMID = 16847722.001).
  • [ISSN] 1021-7770
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Ginsenosides; 0 / Inflammation Mediators; 0 / Serum Albumin, Bovine; 33507-63-0 / Substance P; 88140-34-5 / ginsenoside Rb1, malonyl
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52. Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD: Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. J Pharmacol Exp Ther; 2007 Jul;322(1):332-40
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  • Using rat basophilic leukemia 2H3 cell line (RBL-2H3), we previously established that activation of A(3) adenosine receptors (A(3)AR) stimulates SERT activity via both PKG and p38 MAPK (Zhu et al., 2004a).

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  • (PMID = 17460150.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA07390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Adenosine A3; 0 / Serotonin Plasma Membrane Transport Proteins; 152918-18-8 / N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; 20125-40-0 / N-(1-methyl-2-phenylethyl)adenosine; 333DO1RDJY / Serotonin; 35920-39-9 / Adenosine-5'-(N-ethylcarboxamide); EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; K72T3FS567 / Adenosine
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53. Kim Y, Eom S, Kim K, Lee YS, Choe J, Hahn JH, Lee H, Kim YM, Ha KS, Ro JY, Jeoung D: Transglutaminase II interacts with rac1, regulates production of reactive oxygen species, expression of snail, secretion of Th2 cytokines and mediates in vitro and in vivo allergic inflammation. Mol Immunol; 2010 Feb;47(5):1010-22
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  • Antigen stimulation induced expression and activity of TGase II by activation of NF-kappaB in rat basophilic leukemia (RBL2H3) cells.

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  • [Copyright] (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20004474.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Cadherins; 0 / Carcinogens; 0 / Cytokines; 0 / NF-kappa B; 0 / Neuropeptides; 0 / Rac1 protein, mouse; 0 / Reactive Oxygen Species; EC 2.3.2.- / transglutaminase 2; EC 2.3.2.13 / Transglutaminases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.5.1.98 / Histone Deacetylases; EC 3.5.1.98 / histone deacetylase 3; EC 3.6.1.- / GTP-Binding Proteins; EC 3.6.1.- / Rac1 protein, rat; EC 3.6.5.2 / rac GTP-Binding Proteins; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase; K7Q1JQR04M / Dinoprostone; NI40JAQ945 / Tetradecanoylphorbol Acetate
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54. Blanc F, Adel-Patient K, Drumare MF, Paty E, Wal JM, Bernard H: Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy; 2009 Aug;39(8):1277-85

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  • OBJECTIVES: We optimized an in vitro functional assay to assess the capacity of peanut allergens to degranulate humanized rat basophilic leukaemia cells, RBL SX-38 cells, after sensitization by serum IgE from peanut-allergic patients.
  • [MeSH-major] 2S Albumins, Plant / immunology. Allergens / immunology. Antigens, Plant / immunology. Basophil Degranulation Test. Glycoproteins / immunology. Peanut Hypersensitivity / immunology

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  • (PMID = 19538351.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / Ara h 6 allergen, Arachis hypogaea; 0 / Glycoproteins; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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55. Lim H, Son KH, Chang HW, Bae K, Kang SS, Kim HP: Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull; 2008 Nov;31(11):2063-7
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  • In order to identify the active anti-inflammatory ingredient(s) in Cirsium chanroenicum (Compositae), its methanol extract and several solvent fractions were prepared; the methanol extract and the ethylacetate fraction inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE2) and 5-lipoxygenase (5-LOX)-mediated leukotriene (LT) production in lipopolysaccharide-treated RAW 264.7 cells and A23187-treated rat basophilic leukemia (RBL-1) cells, respectively.

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  • (PMID = 18981574.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Chromones; 0 / Leukotrienes; 0 / NF-kappa B; 0 / pectolinarigenin; 28978-02-1 / pectolinarin; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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56. Kato N, Motohashi S, Okada T, Ozawa T, Mashima K: PICOT, protein kinase C theta-interacting protein, is a novel regulator of FcepsilonRI-mediated mast cell activation. Cell Immunol; 2008 Jan;251(1):62-7
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  • Using PICOT overexpressing rat basophilic leukemia cells (RBL-2H3), we evaluated the effect of PICOT overexpression on the FcepsilonRI-mediated signaling.

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  • (PMID = 18479680.001).
  • [ISSN] 1090-2163
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Carrier Proteins; 0 / Cytokines; 0 / NF-kappa B; 0 / NFATC Transcription Factors; 0 / Receptors, IgE; 0 / Txnl2 protein, mouse; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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57. Smrz D, Lebduska P, Dráberová L, Korb J, Dráber P: Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis. J Biol Chem; 2008 Apr 18;283(16):10904-18
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  • Using rat basophilic leukemia cells as a model, we show that nonapoptotic PS externalization induced through the high affinity IgE receptor (FcepsilonRI) or the glycosylphosphatidylinositol-anchored protein Thy-1 does not correlate with enhanced tyrosine phosphorylation of PLSCR1.

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  • (PMID = 18281686.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Detergents; 0 / Enzyme Inhibitors; 0 / Ionophores; 0 / Phosphatidylserines; 0 / Phospholipid Transfer Proteins; 0 / pervanadate; 37H9VM9WZL / Calcimycin; 3WHH0066W5 / Vanadates; 42HK56048U / Tyrosine
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58. Sagi-Eisenberg R: The mast cell: where endocytosis and regulated exocytosis meet. Immunol Rev; 2007 Jun;217:292-303
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  • Studying the function of Syt II-knocked down rat basophilic leukemia cells has shown a dual function of this homologue.

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  • (PMID = 17498067.001).
  • [ISSN] 0105-2896
  • [Journal-full-title] Immunological reviews
  • [ISO-abbreviation] Immunol. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Neuronal Calcium-Sensor Proteins; 0 / Neuropeptides; 0 / Receptors, IgE; 0 / frequenin calcium sensor proteins; 134193-27-4 / Synaptotagmins; EC 2.7.11.13 / Protein Kinase C-alpha; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Number-of-references] 138
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59. Giudice ED, Rinaldi L, Passarotto M, Facchinetti F, D'Arrigo A, Guiotto A, Carbonare MD, Battistin L, Leon A: Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells. J Leukoc Biol; 2007 Jun;81(6):1512-22
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  • By using the rat basophilic leukemia mast cell line (RBL-2H3), we demonstrate that CBD (3-10 muM) augments beta-hexosaminidase release, a marker of cell activation, from antigen-stimulated and unstimulated cells via a mechanism, which is not mediated by G(i)/G(o) protein-coupled receptors but rather is associated with a robust rise in intracellular calcium ([Ca(2+)](i)) levels sensitive to clotrimazole and nitrendipine (10-30 muM).

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  • (PMID = 17339608.001).
  • [ISSN] 0741-5400
  • [Journal-full-title] Journal of leukocyte biology
  • [ISO-abbreviation] J. Leukoc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzoxazines; 0 / Cannabinoids; 0 / Cyclohexanols; 0 / Morpholines; 0 / Naphthalenes; 0 / TRPV Cation Channels; 0 / TRPV1 receptor; 134959-51-6 / Win 55212-2; 19GBJ60SN5 / Cannabidiol; 7J8897W37S / Dronabinol; 83003-12-7 / 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; S07O44R1ZM / Capsaicin; SY7Q814VUP / Calcium
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60. Linhart B, Bigenzahn S, Hartl A, Lupinek C, Thalhamer J, Valenta R, Wekerle T: Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol; 2007 Mar 15;178(6):3924-31
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  • Immediate-type reactions as analyzed by a rat basophil leukemia cell mediator release assay were only suppressed by early treatment but not by a costimulation blockade after sensitization.

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  • (PMID = 17339493.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / F 2310
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Immunoconjugates; 0 / Immunosuppressive Agents; 0 / PHLPII protein, Phleum pratense; 0 / Phl p V protein, Phleum pratense; 0 / Plant Proteins; 147205-72-9 / CD40 Ligand; 37341-29-0 / Immunoglobulin E; 7D0YB67S97 / Abatacept
  • [Other-IDs] NLM/ PMC2993922; NLM/ UKMS32950
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61. Heneberg P, Lebduska P, Dráberová L, Korb J, Dráber P: Topography of plasma membrane microdomains and its consequences for mast cell signaling. Eur J Immunol; 2006 Oct;36(10):2795-806
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study we used rat basophilic leukemia cells and their transfectants expressing both endogenous Thy-1.1 and exogenous Thy-1.2 genes and analyzed topography of the Thy-1 isoforms and Thy-1-induced signaling events.

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  • (PMID = 17013982.001).
  • [ISSN] 0014-2980
  • [Journal-full-title] European journal of immunology
  • [ISO-abbreviation] Eur. J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, Thy-1; 0 / Lat protein, mouse; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / Receptors, IgE
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62. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC: Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology; 2006 Jul;131(1):47-58
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  • Finally, delivery of antigen-IgE complexes across the epithelial barrier could induce the degranulation of rat basophil leukemia cells transfected with the human high-affinity IgE receptor.

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  • (PMID = 16831589.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-45343; United States / NIDDK NIH HHS / DK / DK-071576
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / RNA, Messenger; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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63. Toda M, Nakamura T, Ohbayashi M, Ikeda Y, Dawson M, Richardson RM, Alban A, Leed B, Miyazaki D, Ono SJ: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FcepsilonRI- and/or CCR1-engaged mast cells using protein chip technology. Novartis Found Symp; 2005;271:131-40; discussion 140-51
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  • We have found that costimulation with IgE/antigen and CC chemokine ligand 3 (CCL3) enhances degranulation but inhibits chemotaxis of rat basophilic leukaemia (RBL)-2H3 cells expressing human CCR1 (RBL-CCR1 cells).

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  • (PMID = 16605132.001).
  • [ISSN] 1528-2511
  • [Journal-full-title] Novartis Foundation symposium
  • [ISO-abbreviation] Novartis Found. Symp.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / CCR1 protein, human; 0 / CCR3 protein, human; 0 / Ccr1 protein, mouse; 0 / Ccr1 protein, rat; 0 / Ccr3 protein, mouse; 0 / Ccr3 protein, rat; 0 / Chemokines, CC; 0 / Receptors, CCR1; 0 / Receptors, CCR3; 0 / Receptors, Chemokine; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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64. Liu-Bryan R, Pay S, Schraufstatter IU, Rose DM: The CXCR1 tail mediates beta1 integrin-dependent cell migration via MAP kinase signaling. Biochem Biophys Res Commun; 2005 Jun 24;332(1):117-25
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  • We assessed individual contributions of signaling by IL-8 receptors by transfection of CXCR1 and CXCR2 into rat basophilic leukemia (RBL) cells and human monocytic THP-1 cells.

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  • (PMID = 15896307.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL55657; United States / NIAMS NIH HHS / AR / P30AR47360; United States / NIAMS NIH HHS / AR / R03AR49416
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Interleukin-8; 0 / Receptors, Interleukin-8A; 0 / Receptors, Interleukin-8B; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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65. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats

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  • (PMID = 15569773.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / MAIR-I, rat; 0 / Receptors, IgE; 0 / Receptors, Polymeric Immunoglobulin; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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66. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Leukemia, Basophilic, Acute / metabolism. Liver Neoplasms / metabolism. Microscopy, Confocal. NADP / metabolism

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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67. Morikawa T, Xu F, Matsuda H, Yoshikawa M: Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus. Chem Pharm Bull (Tokyo); 2010 Oct;58(10):1379-85
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  • Among the isolates, longusol B (IC(50)=96 µM), luteolin (3.0 µM), resveratrol (17 µM), piceatannol (24 µM), and cassigarols E (84 µM) and G (84 µM) were found to inhibit the release of β-hexosaminidase, as a marker of antigen-induced degranulations, in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 20930408.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Free Radical Scavengers; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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68. Baumann MJ, Eggel A, Amstutz P, Stadler BM, Vogel M: DARPins against a functional IgE epitope. Immunol Lett; 2010 Oct 30;133(2):78-84
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  • Furthermore, anti-IgE DARPins were shown to inhibit proinflammatory mediator release from rat basophilic leukemia cells expressing human high-affinity IgE receptors with higher efficacy than the monoclonal anti-IgE antibody omalizumab.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673836.001).
  • [ISSN] 1879-0542
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / DARPin E2 79; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin Constant Regions; 0 / Recombinant Fusion Proteins; 2P471X1Z11 / Omalizumab; 37341-29-0 / Immunoglobulin E
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69. Ye N, Wang MW, Qin J, Lin B: Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells. Biomed Microdevices; 2010 Jun;12(3):513-21
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  • This work proposed a microfluidic-based method to characterize FPR-related cellular events in response to small peptides, N-formyl-Met-Leu-Phe (fMLF), in rat basophilic leukemia cell line RBL-2H3 expressing human FPR (RBL-FPR).
  • [MeSH-major] Drug Evaluation, Preclinical / instrumentation. Immunoassay / instrumentation. Leukemia, Basophilic, Acute / immunology. Microfluidic Analytical Techniques / instrumentation. Protein Interaction Mapping / instrumentation. Receptors, Formyl Peptide / drug effects. Receptors, Formyl Peptide / immunology

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  • (PMID = 20195765.001).
  • [ISSN] 1572-8781
  • [Journal-full-title] Biomedical microdevices
  • [ISO-abbreviation] Biomed Microdevices
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Formyl Peptide
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70. Heneberg P, Dráberová L, Bambousková M, Pompach P, Dráber P: Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts. J Biol Chem; 2010 Apr 23;285(17):12787-802
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  • We found that exposure of rat basophilic leukemia cells or mouse bone marrow-derived mast cells to PTP inhibitors, H(2)O(2) or pervanadate, induced phosphorylation of the Fc epsilonRI subunits, similarly as Fc epsilonRI triggering.

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  • (PMID = 20157115.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Enzyme Inhibitors; 0 / Oxidants; 0 / Receptors, IgE; 0 / pervanadate; 3WHH0066W5 / Vanadates; BBX060AN9V / Hydrogen Peroxide; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatases
  • [Other-IDs] NLM/ PMC2857068
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71. Chen HJ, Shih CK, Hsu HY, Chiang W: Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem; 2010 Feb 24;58(4):2596-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to investigate the effects of adlay (Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf) testa against beta-hexosaminidase release as a marker of degranulation in rat basophilic leukemia (RBL)-2H3 cells.
  • [MeSH-minor] Acetophenones / pharmacology. Animals. Cell Line, Tumor / drug effects. Cell Line, Tumor / immunology. Coumaric Acids / pharmacology. Ethanol. Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors. Extracellular Signal-Regulated MAP Kinases / drug effects. Leukemia, Basophilic, Acute. Phosphorylation / drug effects. Rats. Signal Transduction / drug effects. Signal Transduction / physiology. beta-N-Acetylhexosaminidases / drug effects. beta-N-Acetylhexosaminidases / secretion

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  • (PMID = 20102206.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Coumaric Acids; 0 / Plant Extracts; 3K9958V90M / Ethanol; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; G1L3HT4CMH / 4-hydroxyacetophenone; IBS9D1EU3J / 4-coumaric acid
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72. Haberman Y, Ziv I, Gorzalczany Y, Hirschberg K, Mittleman L, Fukuda M, Sagi-Eisenberg R: Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells. Blood; 2007 Apr 15;109(8):3385-92
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  • We now show that synaptotagmin (Syt) IX, a Syt homologue that is required for recycling from the endocytic recycling compartment (ERC) in rat basophilic leukemia (RBL-2H3) cultured mast cells, is involved in segregating recycling proteins from the SGs.

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  • (PMID = 17164344.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex 1; 0 / Membrane Glycoproteins; 0 / Tgoln2 protein, rat; 134193-27-4 / Synaptotagmins; EC 3.6.5.2 / ADP-Ribosylation Factor 1
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73. Collaco CR, Hochman DJ, Goldblum RM, Brooks EG: Effect of sodium sulfite on mast cell degranulation and oxidant stress. Ann Allergy Asthma Immunol; 2006 Apr;96(4):550-6
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  • OBJECTIVE: To investigate the cellular responses of sulfite on cultured mast cells (rat basophilic leukemia [RBL-2H3] cells) and human peripheral blood basophils.

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  • (PMID = 16680925.001).
  • [ISSN] 1081-1206
  • [Journal-full-title] Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • [ISO-abbreviation] Ann. Allergy Asthma Immunol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / T32-07524
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Reactive Oxygen Species; 0 / Sulfites; 333DO1RDJY / Serotonin; EC 1.6.3.1 / NADPH Oxidase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; VTK01UQK3G / sodium sulfite
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74. Koumura T, Nakamura C, Nakagawa Y: Role of calcium-induced mitochondrial hydroperoxide in induction of apoptosis of RBL2H3 cells with eicosapentaenoic acid treatment. Free Radic Res; 2005 Oct;39(10):1083-9
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  • Eicosapentaenoic acid (EPA) was previously shown to induce caspase-independent apoptosis in rat basophilic leukemia cells (RBL2H3 cells) by translocation of apoptosis-inducing factor (AIF) [Free Radic Res (2005) 39, 225-235].

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  • (PMID = 16298733.001).
  • [ISSN] 1071-5762
  • [Journal-full-title] Free radical research
  • [ISO-abbreviation] Free Radic. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 11103-72-3 / Ruthenium Red; 139890-68-9 / 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; 526U7A2651 / Egtazic Acid; 9007-43-6 / Cytochromes c; AAN7QOV9EA / Eicosapentaenoic Acid; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.12 / phospholipid-hydroperoxide glutathione peroxidase; EC 1.11.1.9 / Glutathione Peroxidase; SY7Q814VUP / Calcium
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75. Semenova SB, Fomina AF, Vassilieva IO, Negulyaev YA: Properties of Mg(2+)-dependent cation channels in human leukemia K562 cells. J Cell Physiol; 2005 Dec;205(3):372-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Properties of Mg(2+)-dependent cation channels in human leukemia K562 cells.
  • Here we present a single channel study of endogenously expressed Mg(2+)-dependent cation channels in the human myeloid leukemia K562 cells.
  • The Mg(2+)-dependent cation channels described in this study differ from the MIC channels described in human T-cells, Jurkat, and rat basophilic leukemia (RBL) cells in their I-V relationships, kinetic parameters and dependence on intracellular divalent cations.
  • [MeSH-major] Cations / metabolism. Ion Channels / metabolism. Leukemia, Myeloid / metabolism. Magnesium / metabolism

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15895364.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Cations; 0 / Ion Channels; 0 / RNA, Messenger; 0 / TRPV Cation Channels; 0 / TRPV6 protein, human; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
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76. Xu F, Matsuda H, Hata H, Sugawara K, Nakamura S, Yoshikawa M: Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chem Pharm Bull (Tokyo); 2009 Oct;57(10):1089-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides.
  • The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined.
  • [MeSH-major] Benzofurans / chemistry. Cell Degranulation / drug effects. Cissus / chemistry. Flavonoids / chemistry. Leukemia / metabolism. Stilbenes / chemistry

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  • (PMID = 19801863.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Flavonoids; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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77. Tiede LM, Nichols MG: Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy. Photochem Photobiol; 2006 May-Jun;82(3):656-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy.
  • The loss of fluorescence because of multiphoton photobleaching was measured by repetitively imaging individual planes within rat basophilic leukemia cells.
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology. NAD / radiation effects. Photobleaching

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  • (PMID = 16426080.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0U46U6E8UK / NAD
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78. Hochwallner H, Schulmeister U, Swoboda I, Balic N, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, van Tol EA, Valenta R, Spitzauer S: Microarray and allergenic activity assessment of milk allergens. Clin Exp Allergy; 2010 Dec;40(12):1809-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The allergenic activity of the individual allergens was tested using patients' sera for loading rat basophil leukaemia cells (RBL) expressing the α-chain of the human receptor FcεRI.

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20860558.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / Milk Proteins; 0 / Receptors, Fc; 37341-29-0 / Immunoglobulin E
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79. Chandrasekaran CV, Gupta A, Agarwal A: Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol; 2010 May 27;129(2):203-7
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  • MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20307638.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Plant Extracts; 1HGW4DR56D / Leukotriene B4; 37H9VM9WZL / Calcimycin
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80. Motojima H, Yamada P, Han J, Ozaki M, Shigemori H, Isoda H: Properties of fulvic acid extracted from excess sludge and its inhibiting effect on beta-hexosaminidase release. Biosci Biotechnol Biochem; 2009 Oct;73(10):2210-6

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  • The biological properties of fulvic acid from excess sludge and solubilized excess sludge showed an inhibitory effect on beta-hexosaminidase release at the antigen-antibody binding stage and antigen-receptor binding stage by using rat basophilic leukemia cells.

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  • (PMID = 19809201.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies; 0 / Benzopyrans; 0 / Sewage; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; XII14C5FXV / fulvic acid
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81. Borges JP, Culerrier R, Aldon D, Barre A, Benoist H, Saurel O, Milon A, Didier A, Rougé P: GATEWAY technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3). Protein Expr Purif; 2010 Apr;70(2):277-82

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  • The reactivity of rMal d 3 towards IgE from apple allergic patients and in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits.

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  • [Copyright] (c) 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19778615.001).
  • [ISSN] 1096-0279
  • [Journal-full-title] Protein expression and purification
  • [ISO-abbreviation] Protein Expr. Purif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Carrier Proteins; 0 / Mal d 3 allergen; 0 / Recombinant Proteins; 0 / lipid transfer protein
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82. Blanc F, Bernard H, Alessandri S, Bublin M, Paty E, Leung SA, Patient KA, Wal JM: Update on optimized purification and characterization of natural milk allergens. Mol Nutr Food Res; 2008 Nov;52 Suppl 2:S166-75
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  • The purified proteins also demonstrated the ability to provoke the degranulation of humanized rat basophilic leukaemia cells.

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  • (PMID = 18504704.001).
  • [ISSN] 1613-4133
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / Lactoglobulins; 9013-90-5 / Lactalbumin
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83. Alvarez-Errico D, Sayós J, López-Botet M: The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. J Immunol; 2007 Jan 15;178(2):808-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the present study, immunoprecipitation analysis revealed that both the p85alpha subunit of PI3K and Src homology region 2 domain-containing phosphatase-1 could be recruited by IREM-1 in transfected cells as well as in the U937 monocytic leukemia cells, which constitutively express the receptor.
  • By assaying the ability of different IREM-1 mutants to regulate the secretion of beta-hexosaminidase induced via FcRepsilonI in rat basophilic leukemia cells, both Y205 and Y249 appeared crucial for IREM-1-mediated inhibition.
  • Remarkably, engagement of an IREM-1 mutant (Y(205,249,284)F), which did not recruit Src homology region 2 domain-containing phosphatase-1 and lost its inhibitory function, induced rat basophilic leukemia cell degranulation.

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  • (PMID = 17202342.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / CD300C protein, human; 0 / GRB2 Adaptor Protein; 0 / Membrane Glycoproteins; 0 / Protein Subunits; 0 / Receptors, IgE; 42HK56048U / Tyrosine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.16 / Protein Phosphatase 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6
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84. Edel JB, Wu M, Baird B, Craighead HG: High spatial resolution observation of single-molecule dynamics in living cell membranes. Biophys J; 2005 Jun;88(6):L43-5
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  • In this letter we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled cell membrane component on a surface containing zero-mode waveguides (ZMWs).

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  • [Cites] Biochem J. 2004 Jul 1;381(Pt 1):13-8 [15128287.001]
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  • (PMID = 15821167.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbocyanines; 0 / Fluorescent Dyes; 40957-95-7 / 3,3'-dioctadecylindocarbocyanine
  • [Other-IDs] NLM/ PMC1305672
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85. Yang W, Chen J, Zhou L: Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol; 2009;28(3):223-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells.
  • In the present work, a mast cell line (rat basophilic leukemia cells, RBL-2H3) was used in vitro to study cellular responses to the stimulus of shear stress generated by a rotating rotor in a cell dish.
  • [MeSH-minor] Animals. Calcium Channels / drug effects. Calcium Channels / physiology. Calcium Signaling / drug effects. Calcium Signaling / physiology. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Indicators and Reagents / pharmacology. Leukemia, Basophilic, Acute. Microcirculation. Rats. Ruthenium Red / pharmacology. Stress, Mechanical. TRPV Cation Channels / antagonists & inhibitors. TRPV Cation Channels / metabolism

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  • (PMID = 19888909.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Indicators and Reagents; 0 / TRPV Cation Channels; 0 / Trpv4 protein, rat; 11103-72-3 / Ruthenium Red; 820484N8I3 / Histamine; SY7Q814VUP / Calcium
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86. Ayuso R, Grishina G, Ibáñez MD, Blanco C, Carrillo T, Bencharitiwong R, Sánchez S, Nowak-Wegrzyn A, Sampson HA: Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. J Allergy Clin Immunol; 2009 Jul;124(1):114-20
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  • BACKGROUND: Shellfish allergy is a long-lasting disorder usually persisting throughout life.
  • A functional assay with a rat basophilic leukemia cell line was used to determine the capacity for mediator release induced by SCP.

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  • (PMID = 19523674.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 05931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Calcium-Binding Proteins; 0 / Recombinant Proteins; 37341-29-0 / Immunoglobulin E; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases
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87. Curtis T, Naal RM, Batt C, Tabb J, Holowka D: Development of a mast cell-based biosensor. Biosens Bioelectron; 2008 Feb 28;23(7):1024-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rat basophilic leukemia (RBL) mast cells offer excellent potential for biosensor applications because they are robust and undergo a dramatic exocytotic response within minutes of antigen addition.

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  • (PMID = 18055192.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI022449-13; United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / AI 22449; United States / NIAID NIH HHS / AI / R01 AI022449-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS40874; NLM/ PMC2269709
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88. Chen HH, Purtteman JJ, Heimfeld S, Folch A, Gao D: Development of a microfluidic device for determination of cell osmotic behavior and membrane transport properties. Cryobiology; 2007 Dec;55(3):200-9
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  • During experiments, rat basophilic leukemia (RBL-1 line) cells were injected into the inlet of the device, allowed to flow downstream, and were trapped within a perfusion chamber.

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  • (PMID = 17889847.001).
  • [ISSN] 1090-2392
  • [Journal-full-title] Cryobiology
  • [ISO-abbreviation] Cryobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dimethylpolysiloxanes; 0 / Silicones; 059QF0KO0R / Water; 63148-62-9 / baysilon
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89. Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, Wang MW: The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol; 2006 Nov 15;177(10):7050-8
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  • More recent studies have shown that CsA also inhibits fMLF-induced degranulation in differentiated HL-60 promyelocytic leukemia cells.
  • In this study we used human neutrophils, differentiated HL-60 cells, and rat basophilic leukemia (RBL)-2H3 cells expressing human FPR (RBL-FPR) to identify the action site of CsA.


90. Brown SL, Jala VR, Raghuwanshi SK, Nasser MW, Haribabu B, Richardson RM: Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. J Immunol; 2006 Sep 1;177(5):3242-9
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  • Rat basophilic leukemia cell line (RBL-2H3) stably expressing wild-type PAFR, PAFR-G alpha(i3), or PAFR-G alpha(q) was generated and characterized.

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  • (PMID = 16920964.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-38910; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Activating Factor; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Interleukin-8A; 0 / platelet activating factor receptor; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; SY7Q814VUP / Calcium
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91. Parusel I, Kahl S, Braasch F, Glowacki G, Halverson GR, Reid ME, Schawalder A, Ortolan E, Funaro A, Malavasi F, Hardie D, Halder S, Buckley CD, Haag F, Koch-Nolte F: A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cell Immunol; 2005 Jul-Aug;236(1-2):59-65
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  • The mAbs reacted weakly also with human umbilical vein endothelial cells and the basophilic leukemia KU-812.

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  • (PMID = 16168396.001).
  • [ISSN] 0008-8749
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL54459
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cell Cycle Proteins; 0 / GML protein, human; 0 / GPI-Linked Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / ART4 protein, human
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92. Linhart B, Hartl A, Jahn-Schmid B, Verdino P, Keller W, Krauth MT, Valent P, Horak F, Wiedermann U, Thalhamer J, Ebner C, Kraft D, Valenta R: A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol; 2005 May;115(5):1010-6
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  • Immune responses to the hybrid molecule were studied in BALB/c mice and rat basophil leukemia assays.
  • IgG antibodies induced by vaccination with the hybrid blocked immediate allergic reactions, as demonstrated by rat basophil degranulation assays in a murine model of grass pollen allergy.

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  • (PMID = 15867859.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin G; 0 / Recombinant Fusion Proteins; 0 / Vaccines; 0 / Vaccines, DNA
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93. Aneiros E, Philipp S, Lis A, Freichel M, Cavalié A: Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells. J Immunol; 2005 Jan 1;174(1):119-30
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  • Using rat basophilic leukemia (RBL) mast cells and murine bone marrow-derived mast cells, we examine the role of Na(+)/Ca(2+) exchangers.

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  • (PMID = 15611234.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sodium-Calcium Exchanger
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94. Jala VR, Shao WH, Haribabu B: Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. J Biol Chem; 2005 Feb 11;280(6):4880-7
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  • These mutants expressed in rat basophilic leukemia RBL-2H3 cells bound LTB4 with similar affinity and activated all of the known functional activities of BLT1, albeit at different levels.

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  • (PMID = 15561704.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-43184; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arrestins; 0 / Epitopes; 0 / Ligands; 0 / Receptors, Leukotriene B4; 0 / beta-arrestin; 147336-22-9 / Green Fluorescent Proteins; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; OF5P57N2ZX / Alanine; SY7Q814VUP / Calcium
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95. Gavina M, Za L, Molteni R, Pardi R, de Curtis I: The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells. Biol Cell; 2010 Jan 14;102(4):231-44
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  • [Title] The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells.
  • We have investigated the function of the endogenous GIT complexes in the regulation of cell motility stimulated by fMLP (formyl-Met-Leu-Phe) peptide, in a rat basophilic leukaemia RBL-2H3 cell line stably expressing an HA (haemagglutinin)-tagged receptor for the fMLP peptide.

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  • (PMID = 19912111.001).
  • [ISSN] 1768-322X
  • [Journal-full-title] Biology of the cell
  • [ISO-abbreviation] Biol. Cell
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / GTPase-Activating Proteins; 0 / Git1 protein, rat; 0 / Git2 protein, rat; 0 / Phosphoproteins; 59880-97-6 / N-Formylmethionine Leucyl-Phenylalanine; EC 2.7.11.1 / p21-Activated Kinases; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2825732
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96. Kobayashi S, Tanabe S: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. Int J Mol Med; 2006 Mar;17(3):511-5
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  • [Title] Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
  • To examine this anti-allergic mechanism in detail, we next used rat basophlilic leukemia RBL-2H3 cells.
  • [MeSH-major] Anti-Allergic Agents / therapeutic use. Basophils / drug effects. Citrus. Leukemia, Basophilic, Acute / immunology. Phytotherapy. Pollen / immunology. Rhinitis, Allergic, Seasonal / drug therapy

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  • (PMID = 16465400.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; 0 / Plant Preparations; 37341-29-0 / Immunoglobulin E; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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97. Rashid A, Iodice MW, Carroll KM, Housden JE, Hunter M, Sabban S, Artymiuk PJ, Helm BA: Assessing the role of Asp 194 in the transmembrane domains of the α-chain of the high-affinity receptor complex for immunoglobulin E in signal transduction. Mol Immunol; 2010 Nov-Dec;48(1-3):128-36
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  • Rat basophilic leukemia cells (RBL-2H3) transfected with the human IgE binding subunit (FcɛRIα) incorporating polar substitutions like asparagine (D194N) or threonine (D194T) resulted in the formation of a functional rat/human chimeric receptor complex.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • [CommentIn] Mol Immunol. 2011 Apr;48(8):979-80 [21216468.001]
  • (PMID = 20947168.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, IgE; 30KYC7MIAI / Aspartic Acid
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98. Cho YS, Kim CH, Surh JH, Kang NS, Yoo SE, Cheon HG: Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity. Pharmacology; 2010;86(2):65-72
Hazardous Substances Data Bank. 1-CHLORO-2,4-DINITROBENZENE .

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  • The leukotriene B(4) (LTB(4)) level was assayed in rat basophilic leukemia (RBL-1) cell line.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20639685.001).
  • [ISSN] 1423-0313
  • [Journal-full-title] Pharmacology
  • [ISO-abbreviation] Pharmacology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / 4-(4-(4-fluorophenyl)thiazol-2-ylamino)-2,6-dimethylphenol; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Isoenzymes; 0 / Lipoxygenase Inhibitors; 0 / Recombinant Proteins; 0 / Thiazoles; 0 / Xylenes; 1HGW4DR56D / Leukotriene B4; 27YG812J1I / Arachidonic Acid; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; GE3IBT7BMN / Dinitrochlorobenzene
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99. Qian W, Zhang X, Li B, Zhang D, Tong Q, Chen L, Zheng L, Kou G, Wang H, Hou S, Guo Y: Development and characterization of a novel anti-IgE monoclonal antibody. Biochem Biophys Res Commun; 2010 May 14;395(4):547-52
Immune Epitope Database and Analysis Resource. gene/protein/disease-specific - Related Immune Epitope Information .

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  • Importantly, 7A5 was able to inhibit IgE-induced histamine release of basophilic leukemia cells.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20394728.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Peptide Library; 0 / Peptides; 0 / Receptors, IgE; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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100. Sakai S, Sugawara T, Kishi T, Yanagimoto K, Hirata T: Effect of glucosamine and related compounds on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice. Life Sci; 2010 Feb 27;86(9-10):337-43
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  • MAIN METHODS: Dinitrophenyl (DNP)-IgE-sensitized rat basophilic leukemia RBL-2H3 cells were treated with glucosamine-HCl (GlcN-HCl), N-acetylglucosamine (GlcNAc), chitin oligomer or chitosan oligomer.

  • MedlinePlus Health Information. consumer health - Edema.
  • Hazardous Substances Data Bank. GLUCOSAMINE .
  • Hazardous Substances Data Bank. 1-FLUORO-2,4-DINITROBENZENE .
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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20093129.001).
  • [ISSN] 1879-0631
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] D241E059U6 / Dinitrofluorobenzene; N08U5BOQ1K / Glucosamine
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