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1. Masamoto Y, Nannya Y, Arai S, Koike Y, Hangaishi A, Yatomi Y, Kurokawa M: Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy. Br J Haematol; 2009 Mar;144(5):798-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Arsenicals / therapeutic use. Basophils / pathology. Leukemia, Promyelocytic, Acute / pathology. Oxides / therapeutic use

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  • (PMID = 19036092.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oxides; S7V92P67HO / arsenic trioxide
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2. Gill RM, Etzell JE: Basophilic leukemia in recurrent chronic myelogenous leukemia blast phase. Am J Hematol; 2007 Aug;82(8):736-7
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  • [Title] Basophilic leukemia in recurrent chronic myelogenous leukemia blast phase.
  • [MeSH-major] Blast Crisis / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology

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  • (PMID = 17492647.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Carriero MV, Longanesi-Cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V: Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis. Mol Cancer Ther; 2009 Sep;8(9):2708-17
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  • Fluorescein-RERF associates with very high affinity to RBL-2H3 rat basophilic leukemia cells expressing the human formyl peptide receptor (FPR).

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  • (PMID = 19706734.001).
  • [ISSN] 1538-8514
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptide Fragments; 0 / Receptors, Urokinase Plasminogen Activator
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4. Nasser MW, Raghuwanshi SK, Malloy KM, Gangavarapu P, Shim JY, Rajarathnam K, Richardson RM: CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization. J Biol Chem; 2007 Mar 2;282(9):6906-15
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  • The receptors were stably expressed in rat basophilic leukemia 2H3 cells and characterized for receptor binding, intracellular Ca(2+) mobilization, phosphoinositide hydrolysis, phosphorylation, internalization, and MAPK activation.

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  • (PMID = 17204468.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI069152; United States / NIAID NIH HHS / AI / AI-069152; United States / NIAID NIH HHS / AI / AI-38910
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-8; 0 / Receptors, Interleukin-8A; 0 / Receptors, Interleukin-8B; 30KYC7MIAI / Aspartic Acid
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5. Ljubić N, Lang N, Skelin IK, Lasan R, Dominis M, Perković L, Zupanić-Krmek D, Grgurević-Batinica A: Klinefelter syndrome and acute basophilic leukaemia--case report. Coll Antropol; 2010 Jun;34(2):657-60
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  • [Title] Klinefelter syndrome and acute basophilic leukaemia--case report.
  • Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia.
  • We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells.
  • Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias.
  • Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules.
  • There is no consistent chromosomal abnormality identified in this leukaemia.
  • This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome.
  • In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
  • [MeSH-major] Klinefelter Syndrome / complications. Leukemia, Basophilic, Acute / complications

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  • (PMID = 20698148.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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6. Huang YF, Liu H, Xiong X, Chen Y, Tan W: Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells. J Am Chem Soc; 2009 Dec 2;131(47):17328-34
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  • We found that both nanoparticle size and surface ligand density play key regulatory roles in the process of membrane antibody-receptor (IgE-Fc epsilonRI) binding and cross-linking, which, in turn, leads to degranulation and consequent release of chemical mediators on rat basophilic leukemia cells.

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  • (PMID = 19929020.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM079359; United States / NIGMS NIH HHS / GM / R01 GM079359-01; None / None / / R01 GM079359-01; United States / NIGMS NIH HHS / GM / R01 GM079359-02; United States / NIGMS NIH HHS / GM / R01 GM079359-03; None / None / / R01 GM079359-02; None / None / / R01 GM079359-01S1; United States / NIGMS NIH HHS / GM / R01 GM079359-01S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
  • [Other-IDs] NLM/ NIHMS158340; NLM/ PMC2786779
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7. Tadokoro S, Kurimoto T, Nakanishi M, Hirashima N: Munc18-2 regulates exocytotic membrane fusion positively interacting with syntaxin-3 in RBL-2H3 cells. Mol Immunol; 2007 Jul;44(13):3427-33
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  • In this study, we investigated the role of Munc18 and its mechanism for regulating exocytotic release (degranulation) in rat basophilic leukemia cells (RBL-2H3).

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  • (PMID = 17408745.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Munc18 Proteins; 0 / Qa-SNARE Proteins; 0 / Stxbp2 protein, rat
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8. Brown SL, Jala VR, Raghuwanshi SK, Nasser MW, Haribabu B, Richardson RM: Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. J Immunol; 2006 Sep 1;177(5):3242-9
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  • Rat basophilic leukemia cell line (RBL-2H3) stably expressing wild-type PAFR, PAFR-G alpha(i3), or PAFR-G alpha(q) was generated and characterized.

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  • (PMID = 16920964.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-38910; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Activating Factor; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Interleukin-8A; 0 / platelet activating factor receptor; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; SY7Q814VUP / Calcium
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9. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7
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  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Line, Tumor. Humans. Intestines / microbiology. Lactobacillus / physiology. Rats. Signal Transduction

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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10. Li Y, Lee SH, Le QT, Kim MM, Kim SK: Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI. J Agric Food Chem; 2008 Dec 24;56(24):12073-80
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  • In this study, anti-allergic activities of phloroglucinol derivatives were assessed on human basophilic leukemia (KU812) and rat basophilic leukemia (RBL-2H3) cell lines using a histamine release assay.

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  • (PMID = 19053379.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Plant Extracts; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; DHD7FFG6YS / Phloroglucinol
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11. Voskoboinik I, Thia MC, Trapani JA: A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood; 2005 Jun 15;105(12):4700-6
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  • In this study, we expressed wild-type and mutated perforin in rat basophil leukemia cells to study the effect on lytic function of the substitutions A91V and N252S (commonly considered to be neutral polymorphisms) and 22 perforin missense substitutions first identified in HLH patients.


12. Quan W, Lee HJ, Kim CY, Noh CW, Um BH, Oak MH, Kim KM: Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med; 2008 Feb;74(2):168-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Animals. Cell Line, Tumor. Leukemia, Basophilic, Acute. Rats. beta-N-Acetylhexosaminidases / antagonists & inhibitors. beta-N-Acetylhexosaminidases / metabolism

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  • (PMID = 18219599.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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13. Lebduska P, Korb J, Tůmová M, Heneberg P, Dráber P: Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells. J Immunol Methods; 2007 Dec 1;328(1-2):139-51
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  • The data were compared with those obtained from widely used but tumor-derived rat basophilic leukemia (RBL) cells.

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  • (PMID = 17900607.001).
  • [ISSN] 0022-1759
  • [Journal-full-title] Journal of immunological methods
  • [ISO-abbreviation] J. Immunol. Methods
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE
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14. Rashid A, Iodice MW, Carroll KM, Housden JE, Hunter M, Sabban S, Artymiuk PJ, Helm BA: Assessing the role of Asp 194 in the transmembrane domains of the α-chain of the high-affinity receptor complex for immunoglobulin E in signal transduction. Mol Immunol; 2010 Nov-Dec;48(1-3):128-36
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  • Rat basophilic leukemia cells (RBL-2H3) transfected with the human IgE binding subunit (FcɛRIα) incorporating polar substitutions like asparagine (D194N) or threonine (D194T) resulted in the formation of a functional rat/human chimeric receptor complex.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • [CommentIn] Mol Immunol. 2011 Apr;48(8):979-80 [21216468.001]
  • (PMID = 20947168.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, IgE; 30KYC7MIAI / Aspartic Acid
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15. Yasui Y, Nakamura M, Onda T, Uehara T, Murata S, Matsui N, Fukuishi N, Akagi R, Suematsu M, Akagi M: Heme oxygenase-1 inhibits cytokine production by activated mast cells. Biochem Biophys Res Commun; 2007 Mar 9;354(2):485-90
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  • We examined whether rat HO-1 cDNA transfected rat basophilic leukemia (RBL)-2H3 cells have altered cytokine production in response to stimulation with anti-ovalbumin (OA) serum/OA compared to Mock transfected RBL-2H3 cells.


16. Fujimura Y, Yamada K, Tachibana H: A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression. Biochem Biophys Res Commun; 2005 Oct 21;336(2):674-81
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  • Here we show that the 67LR is highly associated with lipid rafts on human basophilic KU812 cells.
  • [MeSH-major] Catechin / analogs & derivatives. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / metabolism. Receptors, IgG / metabolism. Receptors, Laminin / metabolism

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  • (PMID = 16140266.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FCGR1A protein, human; 0 / Receptors, IgG; 0 / Receptors, Laminin; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate
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17. Kaito K, Otsubo H, Dobashi N, Usui N, Kobayashi M: CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations. Int J Hematol; 2005 Jan;81(1):29-31
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  • [Title] CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations.
  • We report a patient with a variant form of CD2+ acute promyelocytic leukemia (APL) who had double translocations (15;17) in a single leukemic cell.
  • The bone marrow showed marked hyperplasia with large leukemic cells that had bizarre nuclear configuration and basophilic, hypogranular cytoplasm.
  • Fluorescence in situ hybridization assay revealed 2 promyelocytic leukemia and retinoic acid receptor alpha (PML/RARA) fusion signals, and reverse transcription-polymerase chain reaction assay revealed short-form PML/RARA fusion transcript.
  • Tetraploidy in APL is a very rare abnormality.
  • Double translocations were an additional abnormality in this case, and this patient's karyotype might have had some influence on morphological characteristics, expression of CD2, and poor clinical outcome.
  • [MeSH-major] Antigens, CD2 / genetics. Chromosomes, Human, Pair 15. Chromosomes, Human, Pair 17. Leukemia, Promyelocytic, Acute / genetics. Translocation, Genetic

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  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
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18. Sebastian K, Borowski A, Kuepper M, Friedrich K: Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma. Cell Commun Signal; 2008;6:5
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  • DCs activated by epithelium-derived TSLP can promote naïve CD4+ T cells to adopt a Th2 phenotype, which in turn recruite eosinophilic and basophilic granulocytes as well as mast cells into the airway mucosa.

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  • (PMID = 18724870.001).
  • [ISSN] 1478-811X
  • [Journal-full-title] Cell communication and signaling : CCS
  • [ISO-abbreviation] Cell Commun. Signal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2531181
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19. Sagi-Eisenberg R: The mast cell: where endocytosis and regulated exocytosis meet. Immunol Rev; 2007 Jun;217:292-303
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  • Studying the function of Syt II-knocked down rat basophilic leukemia cells has shown a dual function of this homologue.

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  • (PMID = 17498067.001).
  • [ISSN] 0105-2896
  • [Journal-full-title] Immunological reviews
  • [ISO-abbreviation] Immunol. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Neuronal Calcium-Sensor Proteins; 0 / Neuropeptides; 0 / Receptors, IgE; 0 / frequenin calcium sensor proteins; 134193-27-4 / Synaptotagmins; EC 2.7.11.13 / Protein Kinase C-alpha; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Number-of-references] 138
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20. Dearman RJ, Skinner RA, Deakin N, Shaw D, Kimber I: Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay. Toxicology; 2005 Jan 15;206(2):195-205
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  • [Title] Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay.
  • We have examined the utility of the rat basophilic leukemia (RBL) cell line for the measurement of murine IgE responses.

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  • (PMID = 15588913.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Dinitrobenzenes; 0 / Serum Albumin; 37341-29-0 / Immunoglobulin E; 9006-59-1 / Ovalbumin
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21. Shaik GM, Dráberová L, Heneberg P, Dráber P: Vacuolin-1-modulated exocytosis and cell resealing in mast cells. Cell Signal; 2009 Aug;21(8):1337-45
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  • Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis.

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  • (PMID = 19376224.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Heterocyclic Compounds with 4 or More Rings; 0 / Receptors, IgE; 0 / vacuolin-1; SY7Q814VUP / Calcium
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22. Hashimoto Y, Arai I, Tanaka M, Nakaike S: Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. J Pharmacol Sci; 2005 May;98(1):90-3
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  • Effects of prostaglandin (PG) D(2), PGE(2), and PGI(2) on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined.

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  • (PMID = 15879676.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E; RXY07S6CZ2 / Prostaglandin D2
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23. Heneberg P, Dráberová L, Bambousková M, Pompach P, Dráber P: Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts. J Biol Chem; 2010 Apr 23;285(17):12787-802
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  • We found that exposure of rat basophilic leukemia cells or mouse bone marrow-derived mast cells to PTP inhibitors, H(2)O(2) or pervanadate, induced phosphorylation of the Fc epsilonRI subunits, similarly as Fc epsilonRI triggering.

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  • (PMID = 20157115.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Enzyme Inhibitors; 0 / Oxidants; 0 / Receptors, IgE; 0 / pervanadate; 3WHH0066W5 / Vanadates; BBX060AN9V / Hydrogen Peroxide; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatases
  • [Other-IDs] NLM/ PMC2857068
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24. Yamashita M: Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells. Eur J Pharmacol; 2007 Feb 5;556(1-3):172-80
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  • Peroxisome proliferators Wy-14,643 (30 microM) and fenofibrate (100 microM) significantly inhibited the cysteinyl leukotriene production that was induced by antigen (Ag) treatment after overnight sensitization to Ag specific immunoglobulin E (IgE) in a rat basophilic leukemia (RBL)-2H3 mast cell line.

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  • (PMID = 17113579.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Leukotrienes; 0 / PPAR alpha; 0 / Peroxisome Proliferators; 0 / Pyrimidines; 0 / cysteinyl-leukotriene; 37341-29-0 / Immunoglobulin E; 86C4MRT55A / pirinixic acid; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 1.3.3.6 / Acyl-CoA Oxidase; EC 3.1.1.- / Phospholipases A; EC 3.2.1.- / Hexosaminidases; K848JZ4886 / Cysteine; U202363UOS / Fenofibrate
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25. Han X, Jorgensen JL, Brahmandam A, Schlette E, Huh YO, Shi Y, Awagu S, Chen W: Immunophenotypic study of basophils by multiparameter flow cytometry. Arch Pathol Lab Med; 2008 May;132(5):813-9
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  • CONTEXT: The immunophenotypic profile of basophils is not yet fully established, and the immunophenotypic changes in chronic myelogenous leukemia are not fully characterized.
  • OBJECTIVE: To establish a comprehensive immunophenotypic spectrum of normal basophils and to assess the range of immunophenotypic aberrations of basophils in chronic myelogenous leukemia.
  • DESIGN: Using 4-color flow cytometry, we compared the immunophenotypic profile of basophils in peripheral blood or bone marrow samples from 20 patients with no evidence of neoplasia to basophils from 15 patients with chronic myelogenous leukemia.
  • Basophils in all chronic myelogenous leukemia patients possessed 1 to 5 immunophenotypic aberrancies.
  • CD34 and CD117 were present in cases with basophilic precursors.
  • CONCLUSIONS: Flow cytometric immunophenotyping can identify immunophenotypic aberrations of basophils in chronic myelogenous leukemia, and discriminate basophils from myeloblasts.

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  • (PMID = 18466030.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers
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26. Semenova SB, Fomina AF, Vassilieva IO, Negulyaev YA: Properties of Mg(2+)-dependent cation channels in human leukemia K562 cells. J Cell Physiol; 2005 Dec;205(3):372-8
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  • [Title] Properties of Mg(2+)-dependent cation channels in human leukemia K562 cells.
  • Here we present a single channel study of endogenously expressed Mg(2+)-dependent cation channels in the human myeloid leukemia K562 cells.
  • The Mg(2+)-dependent cation channels described in this study differ from the MIC channels described in human T-cells, Jurkat, and rat basophilic leukemia (RBL) cells in their I-V relationships, kinetic parameters and dependence on intracellular divalent cations.
  • [MeSH-major] Cations / metabolism. Ion Channels / metabolism. Leukemia, Myeloid / metabolism. Magnesium / metabolism

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15895364.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Cations; 0 / Ion Channels; 0 / RNA, Messenger; 0 / TRPV Cation Channels; 0 / TRPV6 protein, human; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
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27. Chen C, Folch A: A high-performance elastomeric patch clamp chip. Lab Chip; 2006 Oct;6(10):1338-45
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  • Here we demonstrate a replica-molded elastomeric patch clamp chip incorporating nanofabricated constrictions, which delivers high-stability gigaseals, with success rates comparable to those of pipettes, using rat basophilic leukemia (RBL) cells.

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  • (PMID = 17102847.001).
  • [ISSN] 1473-0197
  • [Journal-full-title] Lab on a chip
  • [ISO-abbreviation] Lab Chip
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR16302
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ion Channels
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28. Steinmetz C, Shabaik A, Hasteh F: Systemic mastocytosis associated with small lymphocytic lymphoma: an incidental finding in a patient with invasive gastric adenocarcinoma. Diagn Cytopathol; 2007 Nov;35(11):728-33
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  • The Diff-Quick touch preparation of the lymph node revealed abundant single cells and loose aggregates of cells with round to oval nuclei and deeply basophilic granules.
  • [MeSH-major] Adenocarcinoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Mastocytosis, Systemic / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology


29. Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H: Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med; 2007 Jun;73(7):662-5
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  • Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187.

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  • (PMID = 17538871.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Plant Extracts
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30. Yamaki K, Yoshino S: Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. Environ Toxicol Pharmacol; 2010 Mar;29(2):183-9
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  • [Title] Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.
  • The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 21787600.001).
  • [ISSN] 1872-7077
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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31. Chang KP, Lai CH, Huang SH, Tai HT, Chang LL, Lin SD, Hwang SL, Lai CS: Downregulation of Janus kinase 3 expression by small interfering RNA in rat composite tissue allotransplantation. Transpl Immunol; 2009 May;21(1):27-32
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  • The expression vector containing the pre-mRNA expression cassette was transfected into rat basophilic leukemia cell line, RBL-2H3, for RNAi analysis (in vitro).

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  • (PMID = 19233270.001).
  • [ISSN] 1878-5492
  • [Journal-full-title] Transplant immunology
  • [ISO-abbreviation] Transpl. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Jak3 protein, rat; 0 / RNA, Small Interfering; EC 2.7.10.2 / Janus Kinase 3
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32. Ueda N, Tsuboi K, Lambert DM: A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology; 2005 Jun;48(8):1079-85
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  • The inhibitor was a useful tool to distinguish the acid amidase from FAAH with rat basophilic leukemia (RBL-1) cells that express both the enzymes.

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  • (PMID = 15910884.001).
  • [ISSN] 1873-7064
  • [Journal-full-title] Neuropharmacology
  • [ISO-abbreviation] Neuropharmacology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Ethanolamines; 0 / Organophosphonates; 0 / Palmitic Acids; 0 / methyl arachidonylfluorophosphonate; 57KD15003I / Phenylmethylsulfonyl Fluoride; 6R8T1UDM3V / palmidrol; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / N-acylethanolamine amidohydrolase; EC 3.5.1.- / fatty-acid amide hydrolase; T8ID5YZU6Y / Dithiothreitol
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33. Frossi B, Rivera J, Hirsch E, Pucillo C: Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol; 2007 Feb 15;178(4):2549-55
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  • We previously demonstrated that hydrogen peroxide (H(2)O(2)) promotes IL-4 and IL-6 mRNA production and potentates FcepsilonRI-induced cytokine release in rat basophilic leukemia RBL-2H3 cells.


34. Chen HJ, Shih CK, Hsu HY, Chiang W: Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem; 2010 Feb 24;58(4):2596-601
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  • The purpose of this study was to investigate the effects of adlay (Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf) testa against beta-hexosaminidase release as a marker of degranulation in rat basophilic leukemia (RBL)-2H3 cells.
  • [MeSH-minor] Acetophenones / pharmacology. Animals. Cell Line, Tumor / drug effects. Cell Line, Tumor / immunology. Coumaric Acids / pharmacology. Ethanol. Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors. Extracellular Signal-Regulated MAP Kinases / drug effects. Leukemia, Basophilic, Acute. Phosphorylation / drug effects. Rats. Signal Transduction / drug effects. Signal Transduction / physiology. beta-N-Acetylhexosaminidases / drug effects. beta-N-Acetylhexosaminidases / secretion

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  • (PMID = 20102206.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Coumaric Acids; 0 / Plant Extracts; 3K9958V90M / Ethanol; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; G1L3HT4CMH / 4-hydroxyacetophenone; IBS9D1EU3J / 4-coumaric acid
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35. Takahashi Y, Yoneyama S, Yamamoto S, Shibahara T, Kadota K: Acute basophilic leukaemia in a calf. Vet Rec; 2006 May 20;158(20):702-3
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  • [Title] Acute basophilic leukaemia in a calf.
  • [MeSH-major] Cattle Diseases / diagnosis. Leukemia, Basophilic, Acute / veterinary

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  • (PMID = 16714438.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Thors L, Eriksson J, Fowler CJ: Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake. Br J Pharmacol; 2007 Nov;152(5):744-50
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  • BACKGROUND AND PURPOSE: Genistein, a tyrosine kinase inhibitor used to block caveolae dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 17676056.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / DA009789-12A17961; United States / NIDA NIH HHS / DA / P01 DA009789; United States / NIDA NIH HHS / DA / P01 DA009789-12A17961
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Isoflavones; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 10028-17-8 / Tritium; 6287WC5J2L / daidzein; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2190009
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37. Nigro EA, Brini AT, Soprana E, Ambrosi A, Dombrowicz D, Siccardi AG, Vangelista L: Antitumor IgE adjuvanticity: key role of Fc epsilon RI. J Immunol; 2009 Oct 1;183(7):4530-6
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  • [MeSH-minor] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Animals. Antigens, Neoplasm / immunology. Cancer Vaccines / administration & dosage. Cancer Vaccines / genetics. Cancer Vaccines / immunology. Cell Line, Tumor. Cross-Linking Reagents / administration & dosage. Cross-Linking Reagents / metabolism. Cross-Linking Reagents / therapeutic use. Female. Gene Knock-In Techniques. Humans. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / therapy. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / therapy. Mammary Neoplasms, Experimental / immunology. Mammary Neoplasms, Experimental / pathology. Mammary Neoplasms, Experimental / therapy. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. Rats

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  • (PMID = 19748979.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antigens, Neoplasm; 0 / Antineoplastic Agents; 0 / Cancer Vaccines; 0 / Cross-Linking Reagents; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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38. Urrea Moreno R, Gil J, Rodriguez-Sainz C, Cela E, LaFay V, Oloizia B, Herr AB, Sumegi J, Jordan MB, Risma KA: Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood; 2009 Jan 8;113(2):338-46
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  • In a family affected by hemophagocytic lymphohistiocytosis, a severe inflammatory disorder caused by perforin deficiency, we identified 2 amino acid substitutions in the perforin C2 domain: T435M, a previously identified mutant with disputed pathogenicity, and Y438C, a novel substitution.
  • The capacity for cytotoxic function was tested after expression of the variant perforins in rat basophilic leukemia cells and murine cytotoxic T lymphocytes.

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  • (PMID = 18927437.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091769; United States / PHS HHS / / K12 CHILD HEALTH RESEARCH CAREER DEVELOPMENT AWARD; United States / NHLBI NIH HHS / HL / R01-HL091769
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Lipids; 126465-35-8 / Perforin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2615650
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39. Su Z, Guo X, Barker DS, Shoemaker RL, Marchase RB, Blalock JE: A store-operated nonselective cation channel in human lymphocytes. Cell Mol Neurobiol; 2005 Jun;25(3-4):625-47
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  • [MeSH-minor] Animals. Biological Transport / drug effects. Biological Transport / immunology. Calcium / metabolism. Cations / metabolism. Enzyme Inhibitors / pharmacology. Humans. Jurkat Cells. Leukemia, Basophilic, Acute. Membrane Potentials / drug effects. Membrane Potentials / immunology. Rats. Sodium / metabolism. TRPM Cation Channels. Thapsigargin / pharmacology. Transfection

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  • (PMID = 16075382.001).
  • [ISSN] 0272-4340
  • [Journal-full-title] Cellular and molecular neurobiology
  • [ISO-abbreviation] Cell. Mol. Neurobiol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI37670; United States / NIDDK NIH HHS / DK / DK55647; United States / NHLBI NIH HHS / HL / HL68806
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cations; 0 / Enzyme Inhibitors; 0 / Ion Channels; 0 / Membrane Proteins; 0 / TRPM Cation Channels; 0 / TRPM2 protein, human; 67526-95-8 / Thapsigargin; 9NEZ333N27 / Sodium; SY7Q814VUP / Calcium
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40. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Leukemia, Basophilic, Acute / metabolism. Liver Neoplasms / metabolism. Microscopy, Confocal. NADP / metabolism

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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41. Kim Y, Lee YS, Hahn JH, Choe J, Kwon HJ, Ro JY, Jeoung D: Hyaluronic acid targets CD44 and inhibits FcepsilonRI signaling involving PKCdelta, Rac1, ROS, and MAPK to exert anti-allergic effect. Mol Immunol; 2008 May;45(9):2537-47
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  • HA exerted negative effects on beta-hexoaminidase secretion and histamine release in antigen-stimulated rat basophilic leukemia (RBL2H3) cells.


42. Rytting ME, Kantarjian H, Albitar M: Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity. Am J Clin Pathol; 2009 Aug;132(2):182-5; quiz 306
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  • [Title] Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity.
  • Expression of a high level of myeloperoxidase (MPO) as a sole myeloid marker in acute leukemias that express typical lymphoblastic markers is unusual.
  • Herein we report 5 cases of MPO+, otherwise typical acute lymphoblastic leukemia (ALL) without the expression of other myeloid markers.
  • The striking feature of most of these cases is a morphologic picture reminiscent of that seen in Burkitt-like B-cell ALL with basophilic cytoplasm and vacuoles but no expression of surface immunoglobulin.
  • All cases responded to ALL therapy and should be distinguished from myeloid leukemia and from Burkitt leukemia/lymphoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Peroxidase / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

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  • (PMID = 19605811.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.11.1.7 / Peroxidase
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43. Zhang Y, Mi L, Xiong R, Wang PN, Chen JY, Yang W, Wang C, Peng Q: Subcellular Localization of Thiol-Capped CdTe Quantum Dots in Living Cells. Nanoscale Res Lett; 2009;4(7):606-12
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  • These unfunctionalized QDs were well internalized into human hepatocellular carcinoma and rat basophilic leukemia cells in vitro.

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  • (PMID = 20596411.001).
  • [ISSN] 1931-7573
  • [Journal-full-title] Nanoscale research letters
  • [ISO-abbreviation] Nanoscale Res Lett
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Risma KA, Frayer RW, Filipovich AH, Sumegi J: Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest; 2006 Jan;116(1):182-92
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  • We have shown, for the first time to our knowledge, that recombinant human perforin is expressed, processed appropriately, and functional in rat basophilic leukemia (RBL) cells following retroviral transduction.

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  • (PMID = 16374518.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD043005; United States / NICHD NIH HHS / HD / T32 HD43005-02B
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Pore Forming Cytotoxic Proteins; 126465-35-8 / Perforin
  • [Other-IDs] NLM/ PMC1319223
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45. [Picture in clinical hematology. Acute basophilic leukemia]. Rinsho Ketsueki; 2007 Jan;48(1):1
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  • [Title] [Picture in clinical hematology. Acute basophilic leukemia].
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology

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  • (PMID = 17313070.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. Grodzki AC, Moon KD, Berenstein EH, Siraganian RP: FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation. Mol Immunol; 2009 Aug;46(13):2539-47
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  • FcvarepsilonRI-induced mast cell activation was analyzed at a single cell basis using a rat basophilic leukemia (RBL-2H3) cell line transfected with a reporter plasmid containing three tandem NFAT (nuclear factor of activated T cells) binding sites fused to enhanced green fluorescent protein (GFP).

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  • (PMID = 19540596.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DE000696-09; United States / Intramural NIH HHS / / Z99 DE999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 0 / NFATC Transcription Factors; 0 / RNA, Small Interfering; 0 / Receptors, IgE; 0 / Tumor Necrosis Factor-alpha; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS125588; NLM/ PMC2717025
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47. Horny HP, Sotlar K, Stellmacher F, Krokowski M, Agis H, Schwartz LB, Valent P: The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers. J Clin Pathol; 2006 Mar;59(3):298-302
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  • AIMS: Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis.
  • METHODS: A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows).
  • RESULTS: In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML).
  • The basophil specific antigen 2D7 was only detected in CD34/Kit negative TROCI-BM cells in two patients with CMLba.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Basophils / chemistry. Biomarkers / analysis. Cell Lineage. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Leukemia, Mast-Cell / diagnosis. Male. Mast Cells / chemistry. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / genetics. Receptors, Interleukin-2 / analysis. Retrospective Studies. Tryptases

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  • (PMID = 16505282.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.59 / Tryptases
  • [Other-IDs] NLM/ PMC1860329
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48. Qian W, Zhang X, Li B, Zhang D, Tong Q, Chen L, Zheng L, Kou G, Wang H, Hou S, Guo Y: Development and characterization of a novel anti-IgE monoclonal antibody. Biochem Biophys Res Commun; 2010 May 14;395(4):547-52
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  • Importantly, 7A5 was able to inhibit IgE-induced histamine release of basophilic leukemia cells.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20394728.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Peptide Library; 0 / Peptides; 0 / Receptors, IgE; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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49. Agarwal R, Gupta R, Bakhshi S, Sharma A: Unusual cytochemical reactivity for toluidine blue in granular acute lymphoblastic leukemia: a report of two rare cases. Turk J Haematol; 2010 Mar 5;27(1):43-5
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  • [Title] Unusual cytochemical reactivity for toluidine blue in granular acute lymphoblastic leukemia: a report of two rare cases.
  • Azurophilic granulation of blasts is a feature of acute myeloid leukemia (AML).
  • Granular acute lymphoblastic leukemia (ALL) may mimic AML due to the presence of cytoplasmic granules in lymphoblasts, but cytochemistry and immunophenotyping are helpful in making the correct diagnosis.
  • Toluidine blue (TB) is a metachromatic dye, which stains basophils and myeloid blasts that exhibit basophilic differentiation.
  • This report of two rare case highlight the reactivity of lymphoblasts with TB not hitherto described and the importance of a detailed diagnostic work-up in acute leukemia.

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  • (PMID = 27265798.001).
  • [ISSN] 1300-7777
  • [Journal-full-title] Turkish journal of haematology : official journal of Turkish Society of Haematology
  • [ISO-abbreviation] Turk J Haematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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50. Mason MJ, Simpson AK, Mahaut-Smith MP, Robinson HP: The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration. Biophys J; 2005 Jan;88(1):739-50
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  • Membrane potential measurements across intact cell-attached patches in rat basophilic leukemia cells and rat megakaryocytes revealed a surprisingly high degree of accuracy and demonstrated the ability of this noninvasive technique to follow dynamic changes in potential in nonexcitable cells.
  • [MeSH-minor] Adenosine Diphosphate / chemistry. Animals. Cell Line. Cell Line, Tumor. Electrodes. Leukemia / metabolism. Male. Megakaryocytes / metabolism. Membrane Potentials. Models, Theoretical. Rats. Rats, Wistar. Sodium Chloride / pharmacology

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  • (PMID = 15516522.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride; 61D2G4IYVH / Adenosine Diphosphate
  • [Other-IDs] NLM/ PMC1305049
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51. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y: Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol; 2010 Sep;32(3):454-61
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  • To investigate the antiallergic effects of fermented grape marc from Negroamaro (N-FGM), we examined antigen (Ag)-induced degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Antigens / immunology. Basophil Degranulation Test. Fermentation. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein-Tyrosine Kinases / metabolism. Rats. Syk Kinase. Tumor Cells, Cultured

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  • (PMID = 20100066.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D008123/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 37341-29-0 / Immunoglobulin E; 9IKM0I5T1E / Quercetin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Syk Kinase; EC 2.7.10.2 / Syk protein, rat
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52. Lahortiga I, Akin C, Cools J, Wilson TM, Mentens N, Arthur DC, Maric I, Noel P, Kocabas C, Marynen P, Lessin LS, Wlodarska I, Robyn J, Metcalfe DD: Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion. Haematologica; 2008 Jan;93(1):49-56
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  • [Title] Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion.
  • [MeSH-major] Gene Expression Regulation, Leukemic. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Mastocytosis, Systemic / drug therapy. Mastocytosis, Systemic / genetics. Oncogene Proteins, Fusion / genetics. Piperazines / pharmacology. Pyrimidines / pharmacology. Receptor, Platelet-Derived Growth Factor beta / chemistry

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  • (PMID = 18166785.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Benzamides; 0 / Oncogene Proteins, Fusion; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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53. Nugroho AE, Ikawati Z, Sardjiman, Maeyama K: Effects of benzylidenecyclopentanone analogues of curcumin on histamine release from mast cells. Biol Pharm Bull; 2009 May;32(5):842-9
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  • In the present study, fourteen benzylidenecyclopentanone analogues of curcumin were studied for their effects on histamine release from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 19420752.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzylidene Compounds; 0 / Cyclopentanes; 220W81TN3S / cyclopentanone; IT942ZTH98 / Curcumin; SY7Q814VUP / Calcium
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54. Jolly PS, Bektas M, Watterson KR, Sankala H, Payne SG, Milstien S, Spiegel S: Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood; 2005 Jun 15;105(12):4736-42
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  • Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degranulation as well as migration toward antigen.

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  • (PMID = 15741218.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AIS0094; United States / NCI NIH HHS / CA / P30 CA16059
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Culture Media, Serum-Free; 0 / Ligands; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / Receptors, Lysosphingolipid; 37341-29-0 / Immunoglobulin E; 37589-80-3 / Guanosine 5'-O-(3-Thiotriphosphate); EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunit, Gi2; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; EC 3.6.5.1 / Gnai2 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC1894993
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55. Tsai MH, Yang CP, Chung HT, Shih LY: Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. J Pediatr Hematol Oncol; 2009 Dec;31(12):980-2
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  • [Title] Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
  • A 1-year-4-month-old girl who presented with pericardial effusion and superior vena cava (SVC) syndrome caused by a mediastinal mass was later proved to be a case of acute myeloid leukemia (AML) with mixed-lineage leukemia-gene translocation.
  • The unusual presentation and the giant blasts with basophilic vacuolated cytoplasm had led to initial misdiagnosis of mediastinal lymphoma.
  • She developed progressive SVC syndrome, unresolved pericardial effusion, and extensive leukemia cutis after initial induction therapy.
  • To our knowledge, this is the first reported case of childhood acute myeloid leukemia presenting with mediastinal granulocytic sarcoma causing pericardium invasion and SVC syndrome.
  • [MeSH-major] Leukemia, Myeloid, Acute / pathology. Mediastinal Neoplasms / diagnosis. Pericardium / pathology. Sarcoma, Myeloid / diagnosis. Superior Vena Cava Syndrome / diagnosis


56. Atiya-Nasagi Y, Cohen H, Medalia O, Fukudan M, Sagi-Eisenberg R: O-glycosylation is essential for intracellular targeting of synaptotagmins I and II in non-neuronal specialized secretory cells. J Cell Sci; 2005 Apr 1;118(Pt 7):1363-72
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  • We have examined the trafficking of synaptotagmin (Syt) I and II in the mast cell line rat basophilic leukemia (RBL-2H3).

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  • (PMID = 15755799.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Synaptotagmin II; 0 / Syt2 protein, rat; 134193-27-4 / Synaptotagmins; 147336-22-9 / Green Fluorescent Proteins
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57. Horny HP, Sotlar K, Valent P: Differential diagnoses of systemic mastocytosis in routinely processed bone marrow biopsy specimens: a review. Pathobiology; 2010;77(4):169-80
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  • Reliable immunohistochemical markers for the diagnosis and grading of SM have been established, but various differential diagnoses including myeloproliferative neoplasms, basophilic and eosinophilic leukemias may be very difficult to delineate.
  • Even more challenging is the recognition of hematological neoplasms with signs of mast cell differentiation but not fulfilling diagnostic criteria for SM, especially the rare myelomastocytic leukemia.
  • This hypogranulation can be regarded as cellular atypia and may lead to the misdiagnosis aspect of monocytic leukemia or histiocytic neoplasm.

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  • (PMID = 20616612.001).
  • [ISSN] 1423-0291
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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58. Brimo F, Popradi G, Michel RP, Auger M: Primary effusion lymphoma involving three body cavities. Cytojournal; 2009;6:21
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  • An examination of the fluid by cytology showed large atypical lymphocytes with abundant basophilic cytoplasm, either central or eccentric nuclei having irregular outlines, and multiple prominent nucleoli.

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  • (PMID = 19876384.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2762694
  • [Keywords] NOTNLM ; Effusion / Epstein–Barr virus / human herpes virus-8 / lymphoma
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59. Aneiros E, Philipp S, Lis A, Freichel M, Cavalié A: Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells. J Immunol; 2005 Jan 1;174(1):119-30
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  • Using rat basophilic leukemia (RBL) mast cells and murine bone marrow-derived mast cells, we examine the role of Na(+)/Ca(2+) exchangers.

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  • (PMID = 15611234.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sodium-Calcium Exchanger
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60. Papapetrou EP, Korkola JE, Sadelain M: A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells. Stem Cells; 2010 Feb;28(2):287-96
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  • These chimeras showed abnormal patterns of erythroid differentiation primarily affecting the proerythroblast to basophilic erythroblast transition, coinciding with the stage where expression of the miRNA cluster is dramatically induced and posttranscriptional gene regulation becomes prominent.
  • [MeSH-minor] Animals. Erythropoiesis / genetics. Erythropoiesis / physiology. Flow Cytometry. Leukemia, Erythroblastic, Acute. Mice. Tumor Cells, Cultured

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  • (PMID = 19911427.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL 57612; United States / NCI NIH HHS / CA / P01 CA059350
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs
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61. Ye YQ, Koshino H, Onose J, Negishi C, Yoshikawa K, Abe N, Takahashi S: Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-alpha production. J Org Chem; 2009 Jun 19;74(12):4642-5
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  • Compound 2 strongly inhibited TNF (tumor necrosis factor)-alpha production in rat basophilic leukemia (RBL-2H3) cells: IC(50) = 3.5 nM, while a mixture of 1 and its regioisomer 15 showed no such activity.
  • [MeSH-minor] Animals. Cell Line, Tumor. Leukemia, Basophilic, Acute / metabolism. Nuclear Magnetic Resonance, Biomolecular. Rats. Stereoisomerism

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  • (PMID = 19453155.001).
  • [ISSN] 1520-6904
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Terphenyl Compounds; 0 / Tumor Necrosis Factor-alpha
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62. Blonski WC, Katzka DA, Lichtenstein GR, Metz DC: Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Apr;17(4):441-4
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  • [Title] Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease.
  • Many gastric acid hypersecretory states (basal acid output of greater than 15.0 mEq/h) exist for which the etiology is known, such as Zollinger-Ellison syndrome, systemic mastocytosis, antral exclusion, antral predominant Helicobacter pylori gastritis (antral G cell hyperplasia), chronic gastric outlet obstruction, short gut syndrome and basophilic leukemias.

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Dec;17(12):1433 [16292103.001]
  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Sep;17(9):1001 [16093882.001]
  • (PMID = 15756097.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Gastrins; KG60484QX9 / Omeprazole
  • [Number-of-references] 28
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63. Venizelos ID, Klonizakis I, Vlahaki E, Haralambidou S, Tatsiou Z, Ioannidou E: Skin relapse of acute myeloid leukemia associated with trisomy 8. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Jun;16(2):77-80
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  • [Title] Skin relapse of acute myeloid leukemia associated with trisomy 8.
  • Acute myeloid leukemia (AML) is a morphologically diverse group of hematopoietic malignancies characterized by proliferation of immature cells that arise in the myeloid progenitor cells of the bone marrow.
  • A skin nodule from the right arm was excised and histology showed a diffuse infiltration of the dermis consisting of large cells with round to oval nuclei and little basophilic cytoplasm.
  • [MeSH-major] Chromosomes, Human, Pair 8. Leukemia, Myeloid, Acute / pathology. Skin Neoplasms / pathology. Trisomy

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  • (PMID = 17992463.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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64. Hunter MJ, Iodice MW, Pathak AK, Street MA, Helm BA: Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. Mol Immunol; 2009 Mar;46(6):1260-5
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  • A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell line transfected with the alpha-chain subunit of the canine high-affinity IgE receptor using flow cytometry show that canine IgE recognizes the alpha-chain of its cognate receptor on both cell lines.

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  • (PMID = 19135724.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBSQ/Q/2005/06706
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; 37H9VM9WZL / Calcimycin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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65. Knipping K, van Esch EC, Wijering SC, van der Heide S, Dubois AE, Garssen J: In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood); 2008 Nov;233(11):1469-77
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  • AL was selected out of 10,000 herbal extracts in a set-up for high throughput screening in which the degree of degranulation was monitored by the release of beta-hexosaminidase from rat basophil leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Basophils / drug effects. Basophils / metabolism. Chemical Fractionation. Chromatography, High Pressure Liquid. Ear Diseases / chemically induced. Ear Diseases / drug therapy. Edema / chemically induced. Edema / drug therapy. Humans. Leukocytes, Mononuclear / drug effects. Leukocytes, Mononuclear / metabolism. Leukotrienes / biosynthesis. Mice. Rats

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  • (PMID = 18703753.001).
  • [ISSN] 1535-3702
  • [Journal-full-title] Experimental biology and medicine (Maywood, N.J.)
  • [ISO-abbreviation] Exp. Biol. Med. (Maywood)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Anti-Inflammatory Agents; 0 / Leukotrienes; 0 / Plant Extracts
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66. Morikawa T, Xu F, Matsuda H, Yoshikawa M: Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus. Chem Pharm Bull (Tokyo); 2010 Oct;58(10):1379-85
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  • Among the isolates, longusol B (IC(50)=96 µM), luteolin (3.0 µM), resveratrol (17 µM), piceatannol (24 µM), and cassigarols E (84 µM) and G (84 µM) were found to inhibit the release of β-hexosaminidase, as a marker of antigen-induced degranulations, in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 20930408.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Free Radical Scavengers; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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67. Chandrasekaran CV, Gupta A, Agarwal A: Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol; 2010 May 27;129(2):203-7
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  • MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20307638.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Plant Extracts; 1HGW4DR56D / Leukotriene B4; 37H9VM9WZL / Calcimycin
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68. Baumann MJ, Eggel A, Amstutz P, Stadler BM, Vogel M: DARPins against a functional IgE epitope. Immunol Lett; 2010 Oct 30;133(2):78-84
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  • Furthermore, anti-IgE DARPins were shown to inhibit proinflammatory mediator release from rat basophilic leukemia cells expressing human high-affinity IgE receptors with higher efficacy than the monoclonal anti-IgE antibody omalizumab.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673836.001).
  • [ISSN] 1879-0542
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / DARPin E2 79; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin Constant Regions; 0 / Recombinant Fusion Proteins; 2P471X1Z11 / Omalizumab; 37341-29-0 / Immunoglobulin E
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69. Xue J, Zhao Q, Zhu L, Zhang W: Deglycosylation of FcalphaR at N58 increases its binding to IgA. Glycobiology; 2010 Jul;20(7):905-15
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  • Similar result was shown for N58Q-FcalphaR transfected RBL2H3, a rat basophilic leukemia cell line.

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  • (PMID = 20378933.001).
  • [ISSN] 1460-2423
  • [Journal-full-title] Glycobiology
  • [ISO-abbreviation] Glycobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / Immunoglobulin A; 0 / Receptors, Fc; 0RH81L854J / Glutamine; 7006-34-0 / Asparagine
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70. Puri N, Roche PA: Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic; 2006 Nov;7(11):1482-94
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  • To investigate the role of lipid rafts in secretory granule exocytosis, we examined the raft association of SNARE proteins and SNARE complexes in rat basophilic leukemia (RBL) mast cells.

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  • (PMID = 16984405.001).
  • [ISSN] 1398-9219
  • [Journal-full-title] Traffic (Copenhagen, Denmark)
  • [ISO-abbreviation] Traffic
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dinitrophenols; 0 / Qa-SNARE Proteins; 0 / Receptors, IgE; 0 / SNARE Proteins; 0 / Serum Albumin, Bovine; 0 / Snap23 protein, rat; 0 / Snap25 protein, mouse; 0 / Synaptosomal-Associated Protein 25; 0 / Vesicle-Associated Membrane Protein 2; 0 / Vesicular Transport Proteins; 0 / dinitrophenyl-bovine serum albumin; 37341-29-0 / Immunoglobulin E; 9012-63-9 / Cholera Toxin
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71. Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H: Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Infect Immun; 2007 Feb;75(2):801-9
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  • Rat basophilic leukemia (RBL) cells were synchronized using the thymidine double-block technique.

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  • (PMID = 17145947.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Bacterial Toxins; 0 / Caspase Inhibitors; 0 / Enzyme Inhibitors; 0 / Oligopeptides; 0 / acetyl-aspartyl-methionyl-glutaminyl-aspartyl-aldehyde; 0 / toxB protein, Clostridium difficile; EC 3.4.22.- / Caspase 3; EC 3.6.5.2 / cdc42 GTP-Binding Protein; EC 3.6.5.2 / rhoA GTP-Binding Protein; EC 3.6.5.2 / rhoB GTP-Binding Protein
  • [Other-IDs] NLM/ PMC1828479
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72. Radaelli E, Marchesi F, Patton V, Scanziani E: Diagnostic exercise: sudden death in a mouse with experimentally induced acute myeloid leukemia. Vet Pathol; 2009 Nov;46(6):1301-5
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  • [Title] Diagnostic exercise: sudden death in a mouse with experimentally induced acute myeloid leukemia.
  • A 22-week-old female 129/SvEv mouse suddenly died in the context of an experiment aimed at defining the efficacy of valproic acid in a mouse model of PML/RARalpha-induced acute myeloid leukemia.
  • Histologic analysis confirmed the mouse as being affected by a progressive myeloid leukemia, with infiltration of the spleen, bone marrow, liver, kidneys, and lungs.
  • Variably sized intravascular clumps (emboli) of dense basophilic material admixed with necrotic or lytic neoplastic cells were also observed in multiple organs.
  • A positive reaction to Feulgen and Hoechst stain confirmed the high content in chromatin of these basophilic emboli.
  • Cleaved caspase-3 activity was demonstrated both in the leukemic infiltrates and among the intravascular necrotic or lytic neoplastic cells accompanying the basophilic emboli.
  • [MeSH-major] Leukemia, Myeloid, Acute / chemically induced. Tumor Lysis Syndrome / veterinary

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  • (PMID = 19605917.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 614OI1Z5WI / Valproic Acid
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73. Spendier K, Carroll-Portillo A, Lidke KA, Wilson BS, Timlin JA, Thomas JL: Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces. Biophys J; 2010 Jul 21;99(2):388-97
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  • [Title] Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces.
  • We have quantified the spatiotemporal dynamics of the redistribution of immunoglobulin E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells in contact with fluid and gel-phase membranes displaying ligands for immunoglobulin E, using total internal reflection fluorescence microscopy.
  • [MeSH-major] 1,2-Dipalmitoylphosphatidylcholine / metabolism. Cell Membrane / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Phosphatidylcholines / metabolism. Receptors, IgE / metabolism

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  • [Copyright] Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20643056.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI051575; United States / NIAID NIH HHS / AI / R01 AI051575-08
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ligands; 0 / Phosphatidylcholines; 0 / Receptors, IgE; 2644-64-6 / 1,2-Dipalmitoylphosphatidylcholine; TE895536Y5 / 1-palmitoyl-2-oleoylphosphatidylcholine
  • [Other-IDs] NLM/ PMC2905106
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74. Tefferi A, Elliott MA, Pardanani A: Atypical myeloproliferative disorders: diagnosis and management. Mayo Clin Proc; 2006 Apr;81(4):553-63
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  • The World Health Organization system for classification of tumors of the hematopoietic system divides myeloid disorders into acute myeloid leukemia and chronic myeloid disorders based on the presence or absence, respectively, of acute myeloid leukemia--defining morphological and cytogenetic features including the presence of 20% or more myeloblasts in either the bone marrow or the peripheral blood.
  • Classic MPD includes polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, and chronic myeloid leukemia.
  • The current review focuses on the diagnosis and treatment of both molecularly defined and clinicopathologically assigned categories of atypical MPD: chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, chronic neutrophilic leukemia, chronic basophilic leukemia, chronic eosinophilic leukemia, idiopathic eosinophilia including hypereosinophilic syndrome, systemic mastocytosis, unclassified MPD, and eosinophilic/mast cell disorders associated with mutations of platelet-derived growth factor receptors alpha (PDGFRA) and beta (PDGFRB), FGFR1, and KIT.

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  • (PMID = 16610578.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 173
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75. Braham Jmili N, Omri H, Senana Sendi H, Fekih S, Hizem S, Sriha B, Khelif A, Saad A, Kortas M: Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature. Clin Lab; 2006;52(3-4):125-30
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  • [Title] Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature.
  • The Wright-Giemsa stained bone marrow and peripheral blood smears showed a population of blast cells characterized by cells with high N/C and strongly basophilic cytoplasm without granules.
  • The diagnosis of acute myeloid leukaemia (AML) was then evoked initially.
  • From the biological findings the patient was retrospectively diagnosed as having promyelocytic leukemia (hyperbasophilic form).
  • [MeSH-major] Chromosomes, Human, Pair 15. Chromosomes, Human, Pair 17. Leukemia, Myeloid, Acute / genetics. Leukemia, Promyelocytic, Acute / genetics. Neoplasms, Second Primary / genetics. Translocation, Genetic


76. Nichols MG, Barth EE, Nichols JA: Reduction in DNA synthesis during two-photon microscopy of intrinsic reduced nicotinamide adenine dinucleotide fluorescence. Photochem Photobiol; 2005 Mar-Apr;81(2):259-69
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  • When imaging the punctate mitochondrial fluorescence originating from NAD(P)H in a rat basophilic leukemia (RBL) cell at low laser powers, no morphological changes are evident, and photobleaching is not observed when many images are taken.
  • [MeSH-major] DNA / biosynthesis. Leukemia, Basophilic, Acute / metabolism. Microscopy, Fluorescence, Multiphoton / methods. NADP / metabolism

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  • (PMID = 15647000.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP; 9007-49-2 / DNA
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77. Tiede LM, Nichols MG: Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy. Photochem Photobiol; 2006 May-Jun;82(3):656-64
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  • [Title] Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy.
  • The loss of fluorescence because of multiphoton photobleaching was measured by repetitively imaging individual planes within rat basophilic leukemia cells.
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology. NAD / radiation effects. Photobleaching

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  • (PMID = 16426080.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0U46U6E8UK / NAD
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78. Jung ID, Lee HS, Lee HY, Choi OH: FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. Cell Signal; 2009 Nov;21(11):1698-705
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  • IgE-sensitized rat basophilic leukemia (RBL)-2H3 mast cells have been shown to migrate towards antigen.

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  • (PMID = 19632319.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL068879-02; United States / NHLBI NIH HHS / HL / R01 HL068879-04; United States / NHLBI NIH HHS / HL / R01 HL068879-05; United States / NHLBI NIH HHS / HL / HL068879-04; United States / NHLBI NIH HHS / HL / HL068879-02; United States / NHLBI NIH HHS / HL / HL068879-05; United States / NHLBI NIH HHS / HL / HL068879-03; United States / NHLBI NIH HHS / HL / R01 HL68879; United States / NHLBI NIH HHS / HL / R01 HL068879-03; United States / NHLBI NIH HHS / HL / R01 HL068879
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Lysophospholipids; 0 / Receptors, IgE; 0 / Receptors, Lysosphingolipid; 26993-30-6 / sphingosine 1-phosphate; 37341-29-0 / Immunoglobulin E; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; NGZ37HRE42 / Sphingosine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS139214; NLM/ PMC2752894
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79. Wu J, Ji C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP: FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol; 2007 Mar 15;178(6):3973-82
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  • The two different alleles demonstrate significantly different FcalphaRI-mediated intracellular calcium mobilization and degranulation in rat basophilic leukemia cells and cytokine production (IL-6 and TNF-alpha) in murine macrophage P388D1 cells.

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  • (PMID = 17339498.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / P30 AR 48311; United States / NIAMS NIH HHS / AR / R01 AR 33062; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCRR NIH HHS / RR / M01 RR 00032; United States / NIAMS NIH HHS / AR / R01 AR033062; United States / NIAID NIH HHS / AI / N01 AI 40068; United States / NIAMS NIH HHS / AR / P01 AR 49084
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / IL6 protein, human; 0 / Immunoglobulin A; 0 / Interleukin-6; 0 / Receptors, Fc; 0 / Tumor Necrosis Factor-alpha
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80. Torigoe C, Faeder JR, Oliver JM, Goldstein B: Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation. J Immunol; 2007 Mar 15;178(6):3530-5
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  • Experiments in which the concentrations of two ligands with different dwell times are adjusted to equalize the level of LAT phosphorylation in rat basophilic leukemia 2H3 cells show that Erk2 phosphorylation, intracellular Ca(2+), and degranulation exhibit kinetic proofreading downstream of LAT phosphorylation.

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  • (PMID = 17339448.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R37 GM 35556; United States / NIBIB NIH HHS / EB / EB005365-03; United States / NIGMS NIH HHS / GM / F32 GM065794; United States / NIGMS NIH HHS / GM / P20 GM 065794; United States / NIGMS NIH HHS / GM / R37 GM035556; United States / NIBIB NIH HHS / EB / R21 EB005365-03; United States / NIGMS NIH HHS / GM / R01 GM 49814; United States / NIGMS NIH HHS / GM / R01 GM049814
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Lat protein, rat; 0 / Ligands; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Receptors, IgE; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1
  • [Other-IDs] NLM/ NIHMS60574; NLM/ PMC2593628
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81. Leung WH, Bolland S: The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol; 2007 Jul 1;179(1):95-102
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  • Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 interacts with the FcepsilonRI beta-chain, Gab2 and Lyn and that unlike SHIP-1, it does not associate with SHC in mast cells.


82. Matsui T, Nunomura S, Shimokawa T, Yoshimaru T, Ra C: Functionality of the IgA Fc receptor (FcalphaR, CD89) is down-regulated by extensive engagement of FcepsilonRI. Clin Immunol; 2008 Oct;129(1):155-62
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  • Transfected rat basophilic leukemia cell line (RBL-2H3) co-expressing FcepsilonRI and FcalphaR was analyzed for effects of simultaneous receptor engagement by their specific antibodies on degranulation and signaling.

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  • (PMID = 18700185.001).
  • [ISSN] 1521-7035
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Bicyclo Compounds, Heterocyclic; 0 / Fc(alpha) receptor; 0 / Receptors, Fc; 0 / Receptors, IgE; 0 / Thiazolidines; 76343-94-7 / latrunculin B; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.56 / inositol-polyphosphate 5-phosphatase
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83. Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H: Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Planta Med; 2010 Oct;76(14):1512-8
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  • Wight on the basophilic cell-mediated allergic reaction.
  • The effect of acteoside on β-hexosaminidase release and intracellular [Ca (2+)] I level from rat basophilic leukemia (RBL-2H3) cells was determined.
  • Also, ELISA was used to determine the level of histamine, tumor necrosis factor (TNF)- α, and interleukin (IL)-4 on human basophilic (KU812) cells.
  • The effect of acteoside on basophilic cell viability was determined using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay.
  • Our findings provide evidence that acteoside inhibits basophilic cell-derived immediate-type and delayed-type allergic reactions.
  • This is the first report describing antiallergic activity of acteoside extracted from CISTANCHE TUBULOSA on basophilic cells.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20354949.001).
  • [ISSN] 1439-0221
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Catechols; 0 / Glucosides; 0 / Glycosides; 0 / IL4 protein, human; 0 / Phenols; 0 / Tumor Necrosis Factor-alpha; 0 / cistanoside A; 207137-56-2 / Interleukin-4; 37H9VM9WZL / Calcimycin; 61276-17-3 / acteoside; 820484N8I3 / Histamine; 82854-37-3 / echinacoside; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; NI40JAQ945 / Tetradecanoylphorbol Acetate; SY7Q814VUP / Calcium
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84. Rettig JR, Folch A: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem; 2005 Sep 1;77(17):5628-34
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  • We have characterized microwell occupancy by cells for a range of microwell dimensions and seeding parameters and optimized it for fibroblasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cell).

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  • (PMID = 16131075.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R21DC006465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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85. Tanaka A, Tanaka T, Suzuki H, Ishii K, Kameyoshi Y, Hide M: Semi-purification of the immunoglobulin E-sweat antigen acting on mast cells and basophils in atopic dermatitis. Exp Dermatol; 2006 Apr;15(4):283-90
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  • OBJECTIVE: To characterize the biochemical and immunological properties of the substance in sweat that evokes histamine release and to study the usability of the basophil-histamine release test with the sweat antigen for AD.
  • The amount of semi-purified sweat antigen (138 ng protein/ml) that induced a half-maximum reaction of basophils of a patient with AD was utilized for the basophil histamine release test.
  • The involvement of specific IgE and high-affinity IgE receptor (FcepsilonRI) in the reactions was examined using basophils of healthy volunteers, a human mast cell line (LAD2), and a rat basophilic leukemia cell line transfected with human alpha-subunit of FcepsilonRI (RBL-48).


86. Mitsutake S, Igarashi Y: Transbilayer movement of ceramide in the plasma membrane of live cells. Biochem Biophys Res Commun; 2007 Aug 3;359(3):622-7
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  • To produce Cer on the extracellular leaflet of the PM, bacterial sphingomyelinase (SMase) was added to rat basophilic leukemia cells.

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  • (PMID = 17553461.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ceramides; 0 / Membrane Transport Proteins; 0 / Phosphates; 97C5T2UQ7J / Cholesterol; EC 3.1.4.12 / Sphingomyelin Phosphodiesterase
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87. Edwards BS, Young SM, Ivnitsky-Steele I, Ye RD, Prossnitz ER, Sklar LA: High-content screening: flow cytometry analysis. Methods Mol Biol; 2009;486:151-65
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  • [Title] High-content screening: flow cytometry analysis.
  • The HyperCyt high-throughput (HT) flow cytometry sampling platform uses a peristaltic pump, in combination with an autosampler, and a novel approach to data collection, to circumvent time-delay bottlenecks of conventional flow cytometry.
  • This approach also dramatically reduces the amount of sample aspirated for each analysis, typically requiring ~2 microL per sample while making quantitative fluorescence measurements of 40 or more samples per minute with thousands to tens of thousands of cells in each sample.
  • Here, we describe a simple robust screening assay that exploits the high-content measurement capabilities of the flow cytometer to simicroltaneously probe the binding of test compounds to two different receptors in a common assay volume, a duplex assay format.
  • The ability of the flow cytometer to distinguish cell-bound from free fluorophore is also exploited to eliminate wash steps during assay setup.
  • HT flow cytometry with this assay has allowed efficient screening of tens of thousands of small molecules from the NIH Small-Molecule Repository to identify selective ligands for two related G-protein-coupled receptors, the formylpeptide receptor and formylpeptide receptor-like 1.

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  • (PMID = 19347622.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / R03 MH076381; United States / NIMH NIH HHS / MH / U54 MH074425; United States / NIMH NIH HHS / MH / R03 MH076381-01; United States / NIMH NIH HHS / MH / U54 MH074425-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FPR2 protein, human; 0 / Ligands; 0 / Receptors, Formyl Peptide; 0 / Receptors, Lipoxin
  • [Other-IDs] NLM/ NIHMS650482; NLM/ PMC4476789
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88. Grégoire MJ, Latger-Cannard V, Staal A, Bologna S, Leotard B, Rault JP, Béry-Dexheimer M, Jonveaux P: Identification of an acute basophilic leukaemia carrying a rare e6a2 BCR-ABL transcript. Acta Haematol; 2006;116(3):216-8
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  • [Title] Identification of an acute basophilic leukaemia carrying a rare e6a2 BCR-ABL transcript.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Leukemia, Basophilic, Acute / genetics

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  • (PMID = 17016044.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.7.10.2 / Fusion Proteins, bcr-abl
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89. Reese G, Schicktanz S, Lauer I, Randow S, Lüttkopf D, Vogel L, Lehrer SB, Vieths S: Structural, immunological and functional properties of natural recombinant Pen a 1, the major allergen of Brown Shrimp, Penaeus aztecus. Clin Exp Allergy; 2006 Apr;36(4):517-24
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  • The mediator release experiments using both wild-type and humanized rat basophilic leukaemia 30/25 cells showed that rPen a 1 and nPen a 1 induced a similar level of mast cell activation.
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Basophils / immunology. Cells, Cultured. Circular Dichroism / methods. DNA, Circular / chemistry. Female. Humans. Hypersensitivity / immunology. Immunoglobulin E / immunology. Leukemia / immunology. Mice. Mice, Inbred C3H. Models, Biological. Protein Conformation. Radioallergosorbent Test / methods. Rats. Transfection / methods. Tropomyosin / immunology

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  • (PMID = 16630158.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / DNA, Circular; 0 / Pen a 1 allergen, Penaeus aztecus; 0 / Recombinant Proteins; 0 / Tropomyosin; 37341-29-0 / Immunoglobulin E
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90. Stratmann H, Schwan C, Orth JH, Schmidt G, Aktories K: Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin. Cell Signal; 2010 Jul;22(7):1124-31
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  • To activate the GTPase Rac in rat basophilic leukemia (RBL) cells and mouse bone marrow-derived mast cells (BMMC) a TAT fusion toxin of Bordetella dermonecrotic toxin (DNT-TAT) was constructed.

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20211724.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptides; 0 / Recombinant Fusion Proteins; 0 / Virulence Factors, Bordetella; 0 / dermonecrotic toxin, Bordetella; EC 2.3.2.13 / Transglutaminases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / rho GTP-Binding Proteins; SY7Q814VUP / Calcium
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91. Wagner S, Radauer C, Bublin M, Hoffmann-Sommergruber K, Kopp T, Greisenegger EK, Vogel L, Vieths S, Scheiner O, Breiteneder H: Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol; 2008 Jan;121(1):246-52
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  • Isoform structures were compared and related to IgE-binding inhibitory capacities and induction of mediator release in human Fcvarepsilon receptor transformed rat basophilic leukemia cells.

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  • (PMID = 17889932.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Blocking; 0 / Antigens, Plant; 0 / Immunoglobulin G; 0 / Plant Proteins; 0 / Protein Isoforms; 126161-14-6 / Bet v 1 allergen, Betula; 37341-29-0 / Immunoglobulin E
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92. Lim H, Son KH, Chang HW, Bae K, Kang SS, Kim HP: Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull; 2008 Nov;31(11):2063-7
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  • In order to identify the active anti-inflammatory ingredient(s) in Cirsium chanroenicum (Compositae), its methanol extract and several solvent fractions were prepared; the methanol extract and the ethylacetate fraction inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE2) and 5-lipoxygenase (5-LOX)-mediated leukotriene (LT) production in lipopolysaccharide-treated RAW 264.7 cells and A23187-treated rat basophilic leukemia (RBL-1) cells, respectively.

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  • (PMID = 18981574.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Chromones; 0 / Leukotrienes; 0 / NF-kappa B; 0 / pectolinarigenin; 28978-02-1 / pectolinarin; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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93. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Bioorg Med Chem; 2008 Aug 15;16(16):7592-8
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  • [Title] Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
  • It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Calcium / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Histamine Release / drug effects. Immunoblotting. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia, Basophilic, Acute. Phospholipase C gamma / antagonists & inhibitors. Phospholipase C gamma / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Receptors, IgG / metabolism. Signal Transduction / drug effects. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 18656366.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Flavones; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgG; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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94. Huelsenbeck SC, Klose I, Reichenbach M, Huelsenbeck J, Genth H: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. FEBS Lett; 2009 Oct 6;583(19):3133-9
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  • Alternative Ras antibodies including the K-Ras(Mab F234) antibody or the v-H-Ras(Mab Y13-159) antibody recognize Ras proteins regardless of glucosylation. (H/K)Ras are further shown to be more efficaciously glucosylated by TcsL than Rac1 in rat basophilic leukemia cells as well as in a cell-free system.

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  • (PMID = 19744486.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / lethal toxin LT, Clostridium sordellii; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / ras Proteins
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95. Wimazal F, Baumgartner C, Sonneck K, Zauner C, Geissler P, Schur S, Samorapoompichit P, Müllauer L, Födinger M, Agis H, Sperr WR, Valent P: Mixed-lineage eosinophil/basophil crisis in MDS: a rare form of progression. Eur J Clin Invest; 2008 Jun;38(6):447-55
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  • [Title] Mixed-lineage eosinophil/basophil crisis in MDS: a rare form of progression.
  • BACKGROUND: Basophilic crisis and eosinophilia are well recognized features of advanced chronic myeloid leukaemia.
  • DESIGN: We examined the long-term follow-up of 322 patients with de novo myelodysplastic syndromes (MDS) to define the frequency of basophilic, eosinophilic and mixed lineage (basophilic and eosinophilic) transformation.
  • In this patient, who initially suffered from chronic myelomonocytic leukaemia, basophils increased to 48% and eosinophils up to 31% at the time of progression.
  • Myelomastocytic transformation/myelomastocytic leukaemia and primary mast cell disease were excluded by histology, KIT mutation analysis, electron microscopy and immunophenotyping.
  • CONCLUSIONS: Mixed basophil/eosinophil crisis may develop in patients with MDS but is an extremely rare event.
  • [MeSH-major] Basophils / immunology. Eosinophils / immunology. Leukemia, Myelomonocytic, Chronic / immunology

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  • (PMID = 18445043.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Receptors, IgE; X6Q56QN5QC / Hydroxyurea
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96. Källquist L, Rosén H, Nordenfelt P, Calafat J, Janssen H, Persson AM, Hansson M, Olsson I: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. Exp Cell Res; 2010 Nov 15;316(19):3182-96
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  • The NE aminoacid residue Y199 of a proposed NE sorting motif that interacts with AP-3 [2] was not required for proNE processing, sorting or endocytosis in rat basophilic leukemia (RBL) cells expressing heterologous Y199-deleted proNE; this suggests operation of another AP-3-link for proNE targeting.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20828556.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex 3; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / CD63 protein, human; 0 / Cd63 protein, rat; 0 / Enzyme Precursors; 0 / Platelet Membrane Glycoproteins; 42HK56048U / Tyrosine; EC 3.4.21.37 / Leukocyte Elastase; EC 3.4.21.76 / Myeloblastin; EC 5.2.1.- / Tacrolimus Binding Proteins
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97. Koumura T, Nakamura C, Nakagawa Y: Involvement of hydroperoxide in mitochondria in the induction of apoptosis by the eicosapentaenoic acid. Free Radic Res; 2005 Mar;39(3):225-35
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  • Eicosapentaenoic acid (EPA) induced apoptosis of rat basophilic leukemia cells (RBL2H3 cells), whereas 100 microM linoleic acid (LA) had no significant effect.

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  • (PMID = 15788227.001).
  • [ISSN] 1071-5762
  • [Journal-full-title] Free radical research
  • [ISO-abbreviation] Free Radic. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AIFM1 protein, human; 0 / Apoptosis Inducing Factor; 0 / Flavoproteins; 0 / Membrane Proteins; 0 / Pdcd8 protein, mouse; 0 / Pdcd8 protein, rat; 9007-43-6 / Cytochromes c; AAN7QOV9EA / Eicosapentaenoic Acid; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.12 / phospholipid-hydroperoxide glutathione peroxidase; EC 1.11.1.9 / Glutathione Peroxidase; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Casp3 protein, mouse; EC 3.4.22.- / Casp3 protein, rat; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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98. Smetana K, Klamová H, Jirásková I, Mikulenková D: A short cytochemical note on the nucleolar and cytoplasmic RNA concentration in differentiating cells represented by human erythroblasts. Acta Histochem; 2010 Jul;112(4):407-11
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  • The bone marrow of patients suffering from the chronic phase of chronic myeloid leukaemia without a large increase in the granulocyte to erythroid ratio provided erythroblasts for computer-assisted image density measurements of RNA in nucleoli and cytoplasm at the single cell level.
  • In contrast, the nucleolar size significantly decreased even during the early stages of erythroid development (basophilic erythroblasts).
  • [MeSH-minor] Cells, Cultured. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19386355.001).
  • [ISSN] 1618-0372
  • [Journal-full-title] Acta histochemica
  • [ISO-abbreviation] Acta Histochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 63231-63-0 / RNA
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99. Itoh T, Ninomiya M, Nozawa Y, Koketsu M: Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem; 2010 Oct 1;18(19):7052-7
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  • [Title] Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
  • We isolated three chalcone glycosides along with other glycoside constituents from the aerial parts of Brassica rapa L. 'hidabeni' and examined the effects of these compounds on the antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20801664.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Biphenyl Compounds; 0 / Chalcones; 0 / Free Radical Scavengers; 0 / Glycosides; 0 / Picrates; 0 / Plant Extracts; 0 / Reactive Oxygen Species; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl; EC 1.6.3.1 / NADPH Oxidase
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100. Yoshimaru T, Suzuki Y, Inoue T, Nishida S, Ra C: Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products. Biochim Biophys Acta; 2008 Dec;1783(12):2332-43
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  • [MeSH-minor] Advanced Glycosylation End Product-Specific Receptor. Animals. Bone Marrow / metabolism. Calcium / metabolism. Caspase 3 / metabolism. Caspase 7 / metabolism. Cells, Cultured. Cytochromes c / metabolism. Enzyme Activation / drug effects. Glycosylation. Humans. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Membrane Potential, Mitochondrial / drug effects. Mice. Mice, Inbred C3H. Mice, Inbred C57BL. Mitochondrial Membrane Transport Proteins / drug effects. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Small Interfering / pharmacology. Rats. Receptors, IgG / metabolism. Receptors, Immunologic / antagonists & inhibitors. Receptors, Immunologic / genetics. Receptors, Immunologic / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18822320.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / FCGR1A protein, human; 0 / Fcgr1 protein, mouse; 0 / Glycosylation End Products, Advanced; 0 / Mitochondrial Membrane Transport Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, IgG; 0 / Receptors, Immunologic; 0 / Serum Albumin; 0 / glycosylated serum albumin; 0 / mitochondrial permeability transition pore; 11062-77-4 / Superoxides; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7; SY7Q814VUP / Calcium
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