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1. Xu F, Matsuda H, Hata H, Sugawara K, Nakamura S, Yoshikawa M: Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chem Pharm Bull (Tokyo); 2009 Oct;57(10):1089-95
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  • [Title] Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides.
  • The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined.
  • [MeSH-major] Benzofurans / chemistry. Cell Degranulation / drug effects. Cissus / chemistry. Flavonoids / chemistry. Leukemia / metabolism. Stilbenes / chemistry

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  • (PMID = 19801863.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Flavonoids; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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2. Spendier K, Carroll-Portillo A, Lidke KA, Wilson BS, Timlin JA, Thomas JL: Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces. Biophys J; 2010 Jul 21;99(2):388-97
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  • [Title] Distribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces.
  • We have quantified the spatiotemporal dynamics of the redistribution of immunoglobulin E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells in contact with fluid and gel-phase membranes displaying ligands for immunoglobulin E, using total internal reflection fluorescence microscopy.
  • [MeSH-major] 1,2-Dipalmitoylphosphatidylcholine / metabolism. Cell Membrane / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Phosphatidylcholines / metabolism. Receptors, IgE / metabolism

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  • [Copyright] Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20643056.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI051575; United States / NIAID NIH HHS / AI / R01 AI051575-08
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ligands; 0 / Phosphatidylcholines; 0 / Receptors, IgE; 2644-64-6 / 1,2-Dipalmitoylphosphatidylcholine; TE895536Y5 / 1-palmitoyl-2-oleoylphosphatidylcholine
  • [Other-IDs] NLM/ PMC2905106
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3. Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Sep 1;61(Pt 9):812-7
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  • [Title] The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
  • The crystal structure of the human basophilic leukemia-expressed protein (BLES03, p5326, Hs.433573) was determined by single-wavelength anomalous diffraction and refined to an R factor of 18.8% (Rfree = 24.5%) at 2.5 A resolution.

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  • (PMID = 16511166.001).
  • [ISSN] 1744-3091
  • [Journal-full-title] Acta crystallographica. Section F, Structural biology and crystallization communications
  • [ISO-abbreviation] Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P50 GM064598; United States / NIGMS NIH HHS / GM / P50 GM64598
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C11orf68 protein, human; 0 / Eukaryotic Initiation Factor-4E; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1978119
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4. Vonakis BM, Gibbons SP Jr, Rotté MJ, Brothers EA, Kim SC, Chichester K, MacDonald SM: Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI). J Immunol; 2005 Oct 1;175(7):4543-54
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  • [Title] Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI).
  • In the current study, we stably transfected the unique domain of Lyn into rat basophilic leukemia-2H3 mast cells and examined the consequences on Fc epsilonRI-induced signal transduction and mediator secretion to further define the role of the unique domain of Lyn in mast cell secretion.
  • In rat basophilic leukemia-2H3 cells, Lyn thus plays a dual role by positively regulating Fc epsilonRI phosphorylation and degranulation while negatively regulating LTC4 production.
  • [MeSH-minor] Animals. Calcium / metabolism. Cell Line, Tumor. Cell Membrane / physiology. Enzyme Precursors / physiology. Histamine / metabolism. Intracellular Signaling Peptides and Proteins. Kinetics. Leukemia, Basophilic, Acute / metabolism. Mice. Phosphoproteins / physiology. Phosphorylation. Protein Structure, Tertiary / genetics. Protein-Tyrosine Kinases / physiology. Rats. Signal Transduction / physiology. Transfection. Tumor Necrosis Factor-alpha / biosynthesis. Tyrosine / metabolism

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  • (PMID = 16177098.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K22 AI49288; United States / NIAID NIH HHS / AI / R01 AI32651
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / Gab2 protein, rat; 0 / Intracellular Signaling Peptides and Proteins; 0 / Phosphoproteins; 0 / Receptors, IgE; 0 / Tumor Necrosis Factor-alpha; 42HK56048U / Tyrosine; 820484N8I3 / Histamine; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; SY7Q814VUP / Calcium
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5. Dreger SC, Schulz F, Huelsenbeck J, Gerhard R, Hofmann F, Just I, Genth H: Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. Biochemistry; 2009 Mar 3;48(8):1785-92
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  • [Title] Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling.
  • [MeSH-major] Bacterial Toxins / toxicity. Leukemia, Basophilic, Acute / pathology. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction / drug effects

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  • (PMID = 19199813.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / Clostridium difficile lethal toxin B; 0 / lethal toxin LT, Clostridium sordellii; 516-35-8 / Taurochenodeoxycholic Acid; 60EUX8MN5X / tauroursodeoxycholic acid; EC 2.4.- / Glycosyltransferases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.22.- / Caspase 3
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6. Kato N, Nakanishi M, Hirashima N: Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J Immunol; 2006 Jul 1;177(1):147-54
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  • [Title] Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
  • Cross-linking of high-affinity IgE receptors by multivalent Ag on mast cells (rat basophilic leukemia (RBL)-2H3) induces the phosphorylation of ITAM motifs of an IgE receptor by Src family tyrosine kinase, Lyn.
  • We obtained flotillin-1 knockdown (KD)(2) rat basophilic leukemia (RBL)-2H3 cells, which express a low level of flotillin-1.
  • [MeSH-minor] Animals. Calcium / metabolism. Calcium Signaling / physiology. Cell Degranulation / physiology. Cell Line, Tumor. Enzyme Activation / physiology. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / enzymology. Membrane Microdomains / immunology. Membrane Microdomains / metabolism. Phosphorylation. Rats. Transfection. Tyrosine / metabolism. src-Family Kinases / metabolism

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  • (PMID = 16785509.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE; 0 / flotillins; 42HK56048U / Tyrosine; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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7. Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M: Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells. Biol Pharm Bull; 2007 Mar;30(3):443-6
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  • [Title] Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.
  • To trigger degranulation, rat basophilic leukemia (RBL)-2H3 cells were passively sensitized using an antiserum collected from ovalbumin (OA) immunized-Brown Norway rats, and the cells were stimulated by treatment with OA.
  • [MeSH-major] Cell Degranulation. Heme Oxygenase-1 / metabolism. Leukemia, Basophilic, Acute / metabolism

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  • (PMID = 17329835.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 2',7'-dichlorodihydrofluorescein diacetate; 0 / Azo Compounds; 0 / Enzyme Inhibitors; 0 / Fluoresceins; 0 / Free Radical Scavengers; 0 / Metalloporphyrins; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0KAE1U0G7Q / tin mesoporphyrin; 6226-79-5 / ponceau S; 9006-59-1 / Ovalbumin; EC 1.14.99.3 / Heme Oxygenase-1; WYQ7N0BPYC / Acetylcysteine
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8. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Line, Tumor. Humans. Intestines / microbiology. Lactobacillus / physiology. Rats. Signal Transduction

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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9. Kobayashi S, Tanabe S: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. Int J Mol Med; 2006 Mar;17(3):511-5
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  • [Title] Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
  • To examine this anti-allergic mechanism in detail, we next used rat basophlilic leukemia RBL-2H3 cells.
  • [MeSH-major] Anti-Allergic Agents / therapeutic use. Basophils / drug effects. Citrus. Leukemia, Basophilic, Acute / immunology. Phytotherapy. Pollen / immunology. Rhinitis, Allergic, Seasonal / drug therapy

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  • (PMID = 16465400.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; 0 / Plant Preparations; 37341-29-0 / Immunoglobulin E; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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10. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Bioorg Med Chem; 2008 Aug 15;16(16):7592-8
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  • [Title] Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
  • It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Calcium / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Histamine Release / drug effects. Immunoblotting. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia, Basophilic, Acute. Phospholipase C gamma / antagonists & inhibitors. Phospholipase C gamma / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Receptors, IgG / metabolism. Signal Transduction / drug effects. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 18656366.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Flavones; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgG; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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11. Tiede LM, Nichols MG: Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy. Photochem Photobiol; 2006 May-Jun;82(3):656-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy.
  • The loss of fluorescence because of multiphoton photobleaching was measured by repetitively imaging individual planes within rat basophilic leukemia cells.
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology. NAD / radiation effects. Photobleaching

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  • (PMID = 16426080.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / F32 CA 72225; United States / NCRR NIH HHS / RR / RR04224
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0U46U6E8UK / NAD
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12. Barth EE, Hallworth R, Nichols MG: A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells. Photochem Photobiol; 2005 May-Jun;81(3):556-62
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  • [Title] A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells.
  • Photodamage was induced in rat basophilic leukemia cells by either 254-nm UVC light exposure or rose bengal photosensitization.
  • [MeSH-major] Cell Division / radiation effects. Leukemia / pathology. Rose Bengal / toxicity. Ultraviolet Rays / adverse effects

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  • (PMID = 15773792.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Photosensitizing Agents; 1N3CZ14C5O / Rhodamine 123; 1ZPG1ELY14 / Rose Bengal; 36015-30-2 / Propidium; EC 3.1.- / Esterases; G34N38R2N1 / Bromodeoxyuridine; V0YM2B16TS / fluorexon
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13. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. Bioorg Med Chem; 2008 Apr 15;16(8):4500-8
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  • [Title] Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
  • In this study, we examined the effect of xanthones on cell degranulation in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-major] Cell Degranulation / drug effects. Garcinia mangostana / chemistry. Leukemia, Basophilic, Acute / pathology. Xanthones / chemistry. Xanthones / pharmacology

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  • (PMID = 18328716.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgE; 0 / Xanthones; 37341-29-0 / Immunoglobulin E; 820484N8I3 / Histamine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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14. Yamaki K, Yoshino S: Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. Environ Toxicol Pharmacol; 2010 Mar;29(2):183-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.
  • The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 21787600.001).
  • [ISSN] 1872-7077
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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15. Itoh T, Ninomiya M, Nozawa Y, Koketsu M: Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem; 2010 Oct 1;18(19):7052-7
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  • [Title] Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
  • We isolated three chalcone glycosides along with other glycoside constituents from the aerial parts of Brassica rapa L. 'hidabeni' and examined the effects of these compounds on the antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20801664.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Biphenyl Compounds; 0 / Chalcones; 0 / Free Radical Scavengers; 0 / Glycosides; 0 / Picrates; 0 / Plant Extracts; 0 / Reactive Oxygen Species; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl; EC 1.6.3.1 / NADPH Oxidase
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16. Yang W, Chen J, Zhou L: Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol; 2009;28(3):223-30
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  • [Title] Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells.
  • In the present work, a mast cell line (rat basophilic leukemia cells, RBL-2H3) was used in vitro to study cellular responses to the stimulus of shear stress generated by a rotating rotor in a cell dish.
  • [MeSH-minor] Animals. Calcium Channels / drug effects. Calcium Channels / physiology. Calcium Signaling / drug effects. Calcium Signaling / physiology. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Indicators and Reagents / pharmacology. Leukemia, Basophilic, Acute. Microcirculation. Rats. Ruthenium Red / pharmacology. Stress, Mechanical. TRPV Cation Channels / antagonists & inhibitors. TRPV Cation Channels / metabolism

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  • (PMID = 19888909.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Indicators and Reagents; 0 / TRPV Cation Channels; 0 / Trpv4 protein, rat; 11103-72-3 / Ruthenium Red; 820484N8I3 / Histamine; SY7Q814VUP / Calcium
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17. Pidala J, Pinilla-Ibarz J, Cualing HD: A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet; 2008 Apr 1;182(1):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies.
  • A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • [MeSH-major] Chromosomes, Human, Pair 7. Chromosomes, Human, Pair 8. Leukemia, Basophilic, Acute / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Translocation, Genetic

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  • (PMID = 18328951.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Hanashiro K, Sunagawa M, Nakasone T, Nakamura M, Kosugi T: Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs. Int Immunopharmacol; 2007 Jul;7(7):994-1002
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  • [Title] Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs.
  • We examined the effect of antiallergic drugs, azelastine and epinastine, on the expression of FcepsilonRIalpha, beta, and gamma chains and phosphorylation of the gamma chains in rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-major] Anti-Allergic Agents / pharmacology. Dibenzazepines / pharmacology. Imidazoles / pharmacology. Immunoglobulin E / metabolism. Leukemia, Basophilic, Acute / metabolism. Phthalazines / pharmacology. Receptors, IgE / drug effects. Receptors, IgE / metabolism

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  • (PMID = 17499203.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Dibenzazepines; 0 / Imidazoles; 0 / Phthalazines; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; Q13WX941EF / epinastine; ZQI909440X / azelastine
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19. Moser AM, Manor E, Narkis G, Kapelushnik J: Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. Cancer Genet Cytogenet; 2006 Oct 1;170(1):54-7
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  • [Title] Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up.
  • The case of an 11-year-old child with adult-type chronic myeloid leukemia, Philadelphia (BCR-ABL) positive, reverse transcription-polymerase chain reaction negative for the major, minor, and micro breakpoints is presented.
  • In the course of 3 years, the child failed to respond to treatment with hydroxyurea, refused all therapy for 6 months, was intolerant to alpha-interferon and progressed, while on imatinib, to acute basophilic leukemia.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Genes, abl. Leukemia, Basophilic, Acute / surgery. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 16965955.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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20. Olson FJ, Ludowyke RI, Karlsson NG: Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3. J Proteome Res; 2009 Jun;8(6):3068-77
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  • [Title] Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3.
  • This study aimed to identify proteins phosphorylated by serine or threonine kinases in the early stages of mast cell activation, using the rat basophilic leukemia cell line RBL-2H3 as a model system.
  • [MeSH-major] Leukemia, Basophilic, Acute / metabolism. Mast Cells / metabolism. Phosphoproteins / metabolism. Phosphoserine / metabolism. Phosphothreonine / metabolism

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  • (PMID = 19317463.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptide Elongation Factor 2; 0 / Phosphoproteins; 1114-81-4 / Phosphothreonine; 17885-08-4 / Phosphoserine; EC 3.6.4.1 / Myosins
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21. Itoh T, Oyama M, Takimoto N, Kato C, Nozawa Y, Akao Y, Iinuma M: Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Bioorg Med Chem; 2009 Apr 15;17(8):3189-97
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  • [Title] Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
  • Sesquiterpene lactones (SQTLs) have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Calcium / metabolism. Histamine Release / drug effects. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / pathology. Magnetic Resonance Spectroscopy. Mice. Rats. Reactive Oxygen Species. Signal Transduction / drug effects

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  • (PMID = 19318257.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lactones; 0 / Reactive Oxygen Species; 0 / Sesquiterpenes; 37341-29-0 / Immunoglobulin E; SY7Q814VUP / Calcium
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22. Dearman RJ, Skinner RA, Deakin N, Shaw D, Kimber I: Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay. Toxicology; 2005 Jan 15;206(2):195-205
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay.
  • We have examined the utility of the rat basophilic leukemia (RBL) cell line for the measurement of murine IgE responses.

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  • (PMID = 15588913.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Dinitrobenzenes; 0 / Serum Albumin; 37341-29-0 / Immunoglobulin E; 9006-59-1 / Ovalbumin
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23. Liao BC, Hou RC, Wang JS, Jeng KC: Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells. J Biomed Sci; 2006 Sep;13(5):613-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells.
  • In this study, SP and dinitrophenyl-bovine serum albumin (DNP-BSA) were used to activate rat basophilic leukemia (RBL)-2H3 cells.

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  • (PMID = 16847722.001).
  • [ISSN] 1021-7770
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Ginsenosides; 0 / Inflammation Mediators; 0 / Serum Albumin, Bovine; 33507-63-0 / Substance P; 88140-34-5 / ginsenoside Rb1, malonyl
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24. Ozawa T, Nakata K, Mizuno K, Yakura H: Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells. Int Immunol; 2007 Sep;19(9):1049-61
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  • [Title] Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.
  • When phosphatase-inactive SHP-1 was over-expressed in rat basophilic leukemia (RBL)-2H3 cells, tyrosine phosphorylation of a 68-kDa protein was enhanced before and after FcepsilonRI aggregation.
  • [MeSH-major] Leukemia, Basophilic, Acute / immunology. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / immunology

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  • (PMID = 17675340.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Ptpn6 protein, rat
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25. Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M: Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. Bioorg Med Chem; 2009 Aug 1;17(15):5374-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Basophils / cytology. Basophils / drug effects. Basophils / enzymology. Basophils / immunology. Calcium / metabolism. Cell Line, Tumor. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia / enzymology. Leukemia / immunology. Molecular Structure. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Signal Transduction / drug effects. beta-N-Acetylhexosaminidases / antagonists & inhibitors. beta-N-Acetylhexosaminidases / metabolism

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  • (PMID = 19596200.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; SY7Q814VUP / Calcium
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26. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats

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  • (PMID = 15569773.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / MAIR-I, rat; 0 / Receptors, IgE; 0 / Receptors, Polymeric Immunoglobulin; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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27. [Picture in clinical hematology. Acute basophilic leukemia]. Rinsho Ketsueki; 2007 Jan;48(1):1

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  • [Title] [Picture in clinical hematology. Acute basophilic leukemia].
  • [MeSH-major] Leukemia, Basophilic, Acute / pathology

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  • (PMID = 17313070.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Evans NE, Forth MK, Simpson AK, Mason MJ: Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity. Biochim Biophys Acta; 2005 Dec 10;1718(1-2):32-43
The Lens. Cited by Patents in .

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  • [Title] Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity.
  • Using a combination of fluorescence measurements of intracellular Ca(2+) ion concentration ([Ca(2+)](i)) and membrane potential we have investigated the sensitivity to serine/threonine phosphatase inhibition of Ca(2+) entry stimulated by activation of the Ca(2+) release-activated Ca(2+) (CRAC) entry pathway in rat basophilic leukemia cells.
  • [MeSH-minor] Animals. Boron Compounds / pharmacology. Cations, Divalent / metabolism. Cells, Cultured. Ion Transport / drug effects. Leukemia, Basophilic, Acute. Manganese / metabolism. Membrane Potentials / drug effects. Protein Phosphatase 1. Rats. Thapsigargin / pharmacology

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  • (PMID = 16297373.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-aminoethoxydiphenyl borate; 0 / Boron Compounds; 0 / Cations, Divalent; 0 / Enzyme Inhibitors; 0 / Oxazoles; 101932-71-2 / calyculin A; 1W21G5Q4N2 / Okadaic Acid; 42Z2K6ZL8P / Manganese; 67526-95-8 / Thapsigargin; EC 3.1.3.16 / Phosphoprotein Phosphatases; EC 3.1.3.16 / Protein Phosphatase 1; SY7Q814VUP / Calcium
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29. Chen BH, Wu PY, Chen KM, Fu TF, Wang HM, Chen CY: Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod; 2009 May 22;72(5):950-3
The Lens. Cited by Patents in .

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  • In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically.

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  • (PMID = 19271742.001).
  • [ISSN] 1520-6025
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Phenols
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30. Jippo T, Kobayashi Y, Sato H, Hattori A, Takeuchi H, Sugimoto K, Shigekawa M: Inhibitory effects of guarana seed extract on passive cutaneous anaphylaxis and mast cell degranulation. Biosci Biotechnol Biochem; 2009 Sep;73(9):2110-2

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  • Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells.

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  • (PMID = 19734657.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Plant Extracts
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31. Lahortiga I, Akin C, Cools J, Wilson TM, Mentens N, Arthur DC, Maric I, Noel P, Kocabas C, Marynen P, Lessin LS, Wlodarska I, Robyn J, Metcalfe DD: Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion. Haematologica; 2008 Jan;93(1):49-56
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion.
  • [MeSH-major] Gene Expression Regulation, Leukemic. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Mastocytosis, Systemic / drug therapy. Mastocytosis, Systemic / genetics. Oncogene Proteins, Fusion / genetics. Piperazines / pharmacology. Pyrimidines / pharmacology. Receptor, Platelet-Derived Growth Factor beta / chemistry

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  • (PMID = 18166785.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Benzamides; 0 / Oncogene Proteins, Fusion; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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32. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Leukemia, Basophilic, Acute / metabolism. Liver Neoplasms / metabolism. Microscopy, Confocal. NADP / metabolism

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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33. Castellani ML, Petrarca C, Frydas S, Conti CM, Salini V, Conti P, Shanmugham LN: Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers; 2006 Oct-Dec;21(4):211-7
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  • [Title] Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation.
  • [MeSH-major] Chemokine CCL5 / pharmacology. Leukemia, Basophilic, Acute / metabolism. Prostaglandin D2 / biosynthesis

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  • (PMID = 17177158.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Chemokine CCL5; RXY07S6CZ2 / Prostaglandin D2; XXE1CET956 / Indomethacin
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34. Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Koshimizu S, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y: Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. J Agric Food Chem; 2010 Jun 23;58(12):7149-57
MedlinePlus Health Information. consumer health - Allergy.

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  • [Title] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Degranulation / drug effects. Cell Line, Tumor. Disease Models, Animal. Histamine Release / drug effects. Humans. Male. Mice. Mice, Inbred ICR. Quercus / chemistry. Quercus / immunology. Rats. Skin / immunology

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  • (PMID = 20507065.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts; 37341-29-0 / Immunoglobulin E
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35. Qu X, Li Y, Liu J, Xu L, Zhang Y, Hu X, Hou K, Liu Y: Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Mol Cell Biochem; 2010 Jul;340(1-2):107-14
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  • [Title] Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents, Phytogenic / pharmacology. Apoptosis / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Mitogen-Activated Protein Kinase Kinases / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-cbl / metabolism

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  • (PMID = 20177738.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Enzyme Inhibitors; 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 6.3.2.- / Proto-Oncogene Proteins c-cbl; EC 6.3.2.19 / Cblb protein, rat
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36. Cohen R, Torres A, Ma HT, Holowka D, Baird B: Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells. J Immunol; 2009 Nov 15;183(10):6478-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using single cell stimulation by IgE-specific Ag and high-speed imaging of conventional or genetically encoded Ca(2+) sensors in rat basophilic leukemia and bone marrow-derived rat mast cells, we observe Ca(2+) waves that originate most frequently from the tips of extended cell protrusions, as well as Ca(2+) oscillations throughout the cell that usually follow the initiating Ca(2+) wave.
  • Initiating Ca(2+) waves are observed in most rat basophilic leukemia cells stimulated with soluble Ag and are sensitive to inhibitors of Ca(2+) release from endoplasmic reticulum stores and to extracellular Ca(2+), but they do not depend on store-operated Ca(2+) entry.

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  • (PMID = 19864608.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / R01 AI022449-23; United States / NIAID NIH HHS / AI / AI022449
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Estrenes; 0 / Phosphodiesterase Inhibitors; 0 / Pyrrolidinones; 0 / TRPC Cation Channels; 0 / TRPC3 cation channel; 0 / transient receptor potential cation channel, subfamily C, member 1; 112648-68-7 / 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 37341-29-0 / Immunoglobulin E; I9ZF7L6G2L / Nifedipine; NGZ37HRE42 / Sphingosine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS265600; NLM/ PMC3037335
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37. Torres AJ, Vasudevan L, Holowka D, Baird BA: Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays. Proc Natl Acad Sci U S A; 2008 Nov 11;105(45):17238-44
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  • Patterned surfaces that present specific ligands in spatially defined arrays are used to examine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.
  • Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the patterned regions occupied by the ligands and associates preferentially with exposed regions of the silicon substrate.

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  • (PMID = 19004813.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI018306; United States / NIAID NIH HHS / AI / AI18306
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Ligands; 0 / Paxillin; 0 / RNA, Small Interfering; 0 / Receptors, IgE; 0 / Talin; 125361-02-6 / Vinculin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2582307
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38. Li Y, Lee SH, Le QT, Kim MM, Kim SK: Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI. J Agric Food Chem; 2008 Dec 24;56(24):12073-80
MedlinePlus Health Information. consumer health - Allergy.

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  • In this study, anti-allergic activities of phloroglucinol derivatives were assessed on human basophilic leukemia (KU812) and rat basophilic leukemia (RBL-2H3) cell lines using a histamine release assay.

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  • (PMID = 19053379.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Plant Extracts; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; DHD7FFG6YS / Phloroglucinol
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39. Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H: Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med; 2007 Jun;73(7):662-5
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  • Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187.

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  • (PMID = 17538871.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Plant Extracts
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40. Hirose E, Matsushima M, Takagi K, Ota Y, Ishigami K, Hirayama T, Hayashi Y, Nakamura T, Hashimoto N, Imaizumi K, Baba K, Hasegawa Y, Kawabe T: Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells. Inflammation; 2009 Apr;32(2):99-108
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  • In this study, we investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of kaempferol against degranulation in rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Cell Degranulation / drug effects. Cell Line. Flavones. Leukemia / pathology. Rats. Up-Regulation / genetics

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  • (PMID = 19214725.001).
  • [ISSN] 1573-2576
  • [Journal-full-title] Inflammation
  • [ISO-abbreviation] Inflammation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavones; 0 / Kaempferols; 731P2LE49E / kaempferol; EC 1.14.99.3 / Heme Oxygenase-1
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41. Suzuki R, Furuno T, Okamoto K, Teshima R, Nakanishi M: ATP plays a role in neurite stimulation with activated mast cells. J Neuroimmunol; 2007 Dec;192(1-2):49-56
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  • Addition of antigen to the cocultures of superior cervical ganglia (SCG) and rat basophilic leukemia cells (RBLs) elicited Ca(2+) response in RBLs and after a lag period induced Ca(2+) signal in SCG neurites.

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  • (PMID = 17928071.001).
  • [ISSN] 0165-5728
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dinitrophenols; 0 / Receptors, Cell Surface; 0 / Serum Albumin, Bovine; 0 / dinitrophenyl-bovine serum albumin; 333DO1RDJY / Serotonin; 820484N8I3 / Histamine; 8L70Q75FXE / Adenosine Triphosphate; SY7Q814VUP / Calcium
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42. Hashimoto Y, Arai I, Tanaka M, Nakaike S: Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. J Pharmacol Sci; 2005 May;98(1):90-3
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  • Effects of prostaglandin (PG) D(2), PGE(2), and PGI(2) on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined.

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  • (PMID = 15879676.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E; RXY07S6CZ2 / Prostaglandin D2
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43. Motojima H, Yamada P, Han J, Ozaki M, Shigemori H, Isoda H: Properties of fulvic acid extracted from excess sludge and its inhibiting effect on beta-hexosaminidase release. Biosci Biotechnol Biochem; 2009 Oct;73(10):2210-6

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  • The biological properties of fulvic acid from excess sludge and solubilized excess sludge showed an inhibitory effect on beta-hexosaminidase release at the antigen-antibody binding stage and antigen-receptor binding stage by using rat basophilic leukemia cells.

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  • (PMID = 19809201.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies; 0 / Benzopyrans; 0 / Sewage; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; XII14C5FXV / fulvic acid
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44. Wu M, Baumgart T, Hammond S, Holowka D, Baird B: Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays. J Cell Sci; 2007 Sep 1;120(Pt 17):3147-54
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  • To visualize spatial regulation of stimulated secretion within a contact region, we exposed IgE-sensitized rat basophilic leukemia (RBL) mast cells to a surface that was patterned on the microm scale with hapten-containing lipid bilayers to activate cell surface IgE-receptor complexes.

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  • (PMID = 17698921.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI22449
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Cd63 protein, rat; 0 / Platelet Membrane Glycoproteins; 0 / Recombinant Fusion Proteins
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45. Watanabe J, Shinmoto H, Tsushida T: Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. Biosci Biotechnol Biochem; 2005 Jan;69(1):1-6
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  • Estragon and thyme extracts showed potent inhibitory activities against chemical mediator release from rat basophilic leukemia RBL-2H3 cells.

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  • (PMID = 15665459.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Coumarins; 0 / Flavones; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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46. Ye YQ, Koshino H, Onose J, Negishi C, Yoshikawa K, Abe N, Takahashi S: Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-alpha production. J Org Chem; 2009 Jun 19;74(12):4642-5

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  • Compound 2 strongly inhibited TNF (tumor necrosis factor)-alpha production in rat basophilic leukemia (RBL-2H3) cells: IC(50) = 3.5 nM, while a mixture of 1 and its regioisomer 15 showed no such activity.
  • [MeSH-minor] Animals. Cell Line, Tumor. Leukemia, Basophilic, Acute / metabolism. Nuclear Magnetic Resonance, Biomolecular. Rats. Stereoisomerism

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  • (PMID = 19453155.001).
  • [ISSN] 1520-6904
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Terphenyl Compounds; 0 / Tumor Necrosis Factor-alpha
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47. Stratmann H, Schwan C, Orth JH, Schmidt G, Aktories K: Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin. Cell Signal; 2010 Jul;22(7):1124-31
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  • To activate the GTPase Rac in rat basophilic leukemia (RBL) cells and mouse bone marrow-derived mast cells (BMMC) a TAT fusion toxin of Bordetella dermonecrotic toxin (DNT-TAT) was constructed.

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20211724.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptides; 0 / Recombinant Fusion Proteins; 0 / Virulence Factors, Bordetella; 0 / dermonecrotic toxin, Bordetella; EC 2.3.2.13 / Transglutaminases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / rho GTP-Binding Proteins; SY7Q814VUP / Calcium
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48. Alvarez-Errico D, Sayós J, López-Botet M: The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. J Immunol; 2007 Jan 15;178(2):808-16
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  • In the present study, immunoprecipitation analysis revealed that both the p85alpha subunit of PI3K and Src homology region 2 domain-containing phosphatase-1 could be recruited by IREM-1 in transfected cells as well as in the U937 monocytic leukemia cells, which constitutively express the receptor.
  • By assaying the ability of different IREM-1 mutants to regulate the secretion of beta-hexosaminidase induced via FcRepsilonI in rat basophilic leukemia cells, both Y205 and Y249 appeared crucial for IREM-1-mediated inhibition.
  • Remarkably, engagement of an IREM-1 mutant (Y(205,249,284)F), which did not recruit Src homology region 2 domain-containing phosphatase-1 and lost its inhibitory function, induced rat basophilic leukemia cell degranulation.

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  • (PMID = 17202342.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / CD300C protein, human; 0 / GRB2 Adaptor Protein; 0 / Membrane Glycoproteins; 0 / Protein Subunits; 0 / Receptors, IgE; 42HK56048U / Tyrosine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.16 / Protein Phosphatase 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6
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49. Matsui T, Nunomura S, Shimokawa T, Yoshimaru T, Ra C: Functionality of the IgA Fc receptor (FcalphaR, CD89) is down-regulated by extensive engagement of FcepsilonRI. Clin Immunol; 2008 Oct;129(1):155-62

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  • Transfected rat basophilic leukemia cell line (RBL-2H3) co-expressing FcepsilonRI and FcalphaR was analyzed for effects of simultaneous receptor engagement by their specific antibodies on degranulation and signaling.

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  • (PMID = 18700185.001).
  • [ISSN] 1521-7035
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Bicyclo Compounds, Heterocyclic; 0 / Fc(alpha) receptor; 0 / Receptors, Fc; 0 / Receptors, IgE; 0 / Thiazolidines; 76343-94-7 / latrunculin B; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.56 / inositol-polyphosphate 5-phosphatase
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50. Mason MJ, Simpson AK, Mahaut-Smith MP, Robinson HP: The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration. Biophys J; 2005 Jan;88(1):739-50
Hazardous Substances Data Bank. SODIUM CHLORIDE .

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  • Membrane potential measurements across intact cell-attached patches in rat basophilic leukemia cells and rat megakaryocytes revealed a surprisingly high degree of accuracy and demonstrated the ability of this noninvasive technique to follow dynamic changes in potential in nonexcitable cells.
  • [MeSH-minor] Adenosine Diphosphate / chemistry. Animals. Cell Line. Cell Line, Tumor. Electrodes. Leukemia / metabolism. Male. Megakaryocytes / metabolism. Membrane Potentials. Models, Theoretical. Rats. Rats, Wistar. Sodium Chloride / pharmacology

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  • (PMID = 15516522.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride; 61D2G4IYVH / Adenosine Diphosphate
  • [Other-IDs] NLM/ PMC1305049
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51. Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NA, Wilde JI, Scott L, Corazza GR, Lee K, Sengupta N, Knowles CH, Gunthorpe MJ, McLean PG, MacDonald TT, Kruidenier L: Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol; 2009 Sep 1;183(5):3454-62
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  • The inhibitory activity of the CRAC blocker was investigated through patch-clamp experiments on rat basophilic leukemia cells and fluorometric imaging plate reader intracellular Ca(2+) assays using thapsigargin-stimulated Jurkat T cells and its detailed selectivity profile defined using a range of in vitro radioligand binding and functional assays.
  • We found that the CRAC blocker concentration-dependently inhibited CRAC current in rat basophilic leukemia cells and thapsigargin-induced Ca(2+) influx in Jurkat T cells.


52. Hepp R, Puri N, Hohenstein AC, Crawford GL, Whiteheart SW, Roche PA: Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem; 2005 Feb 25;280(8):6610-20
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  • We have investigated the molecular mechanisms of regulated exocytosis in mast cells and find that SNAP-23 is phosphorylated when rat basophilic leukemia mast cells are triggered to degranulate.
  • Regulated exocytosis studies revealed that overexpression of SNAP-23 phosphorylation mutants inhibited exocytosis from rat basophilic leukemia mast cells, demonstrating that phosphorylation of SNAP-23 on Ser(120) and Ser(95) modulates regulated exocytosis by mast cells.

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  • (PMID = 15611044.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Qa-SNARE Proteins; 0 / R-SNARE Proteins; 0 / SNARE Proteins; 0 / Snap23 protein, rat; 0 / Vesicular Transport Proteins; 452VLY9402 / Serine
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53. Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL: Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem; 2006 Jul 28;281(30):20661-5
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  • Expressed alone, Orai1 strongly reduces store-operated Ca(2+) entry (SOCE) in human embryonic kidney 293 cells and the Ca(2+) release-activated Ca(2+) current (I(CRAC)) in rat basophilic leukemia cells.
  • Orai1 and STIM1 coexpression also caused a large gain in CRAC channel function in rat basophilic leukemia cells.

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  • (PMID = 16766533.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI058173; United States / NHLBI NIH HHS / HL / HL55426
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-aminoethoxydiphenyl borate; 0 / Boron Compounds; 0 / Calcium Channels; 0 / Cell Adhesion Molecules; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / STIM1 protein, human; 0 / STIM2 protein, human; SY7Q814VUP / Calcium
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54. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M: Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res; 2008 Nov 21;103(11):1289-99
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  • Using a maneuver that amplifies currents in divalent-free bath solutions, we show that EC CRAC has similar characteristics to that recorded from rat basophilic leukemia cells, namely a similar time course of activation, sensitivity to 2-aminoethoxydiphenyl borate, and low concentrations of lanthanides, and large Na(+) currents displaying the typical depotentiation.
  • Ectopic expression of Stim1 in ECs increased their I(CRAC) to a size comparable to that in rat basophilic leukemia cells.

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  • (PMID = 18845811.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / K22ES014729; United States / NIEHS NIH HHS / ES / ES014729-02; United States / NIEHS NIH HHS / ES / ES014729-01; United States / NIEHS NIH HHS / ES / K22 ES014729; United States / NIEHS NIH HHS / ES / K22 ES014729-02; United States / NIEHS NIH HHS / ES / K22 ES014729-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / DNA Primers; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / Orai1 protein, rat; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / STIM1 protein, human; 0 / Stim1 protein, rat; 0 / TRPC Cation Channels; 0 / transient receptor potential cation channel, subfamily C, member 1; 67526-95-8 / Thapsigargin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS85575; NLM/ PMC2682347
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55. Suzuki M, Nakamura T, Iyoki S, Fujiwara A, Watanabe Y, Mohri K, Isobe K, Ono K, Yano S: Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull; 2005 Aug;28(8):1438-43
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  • The anti-allergic activities were assessed by measurement of histamine release from rat basophilic leukemia cells, RBL-2H3.

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  • (PMID = 16079489.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antioxidants; 11028-71-0 / Concanavalin A; 37H9VM9WZL / Calcimycin; IT942ZTH98 / Curcumin
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56. Atiya-Nasagi Y, Cohen H, Medalia O, Fukudan M, Sagi-Eisenberg R: O-glycosylation is essential for intracellular targeting of synaptotagmins I and II in non-neuronal specialized secretory cells. J Cell Sci; 2005 Apr 1;118(Pt 7):1363-72

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  • We have examined the trafficking of synaptotagmin (Syt) I and II in the mast cell line rat basophilic leukemia (RBL-2H3).

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  • (PMID = 15755799.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Synaptotagmin II; 0 / Syt2 protein, rat; 134193-27-4 / Synaptotagmins; 147336-22-9 / Green Fluorescent Proteins
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57. Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T: Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res; 2009 Oct;58(10):705-15
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  • OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells.
  • [MeSH-minor] Animals. Bilirubin / pharmacology. Carbon Monoxide / pharmacology. Cells, Cultured. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Heme Oxygenase (Decyclizing) / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Metalloporphyrins / pharmacology. Mice. Mice, Inbred BALB C. NF-E2-Related Factor 2 / metabolism. Protoporphyrins / pharmacology. Rats. Rats, Wistar

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  • (PMID = 19390785.001).
  • [ISSN] 1420-908X
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Metalloporphyrins; 0 / NF-E2-Related Factor 2; 0 / Protoporphyrins; 14325-05-4 / tin protoporphyrin IX; 7U1EE4V452 / Carbon Monoxide; 9IKM0I5T1E / Quercetin; EC 1.14.14.18 / Heme Oxygenase (Decyclizing); EC 1.14.14.18 / Heme Oxygenase-1; EC 1.14.14.18 / heme oxygenase-2; RFM9X3LJ49 / Bilirubin
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58. Nakamura R, Nakamura R, Watanabe K, Oka K, Ohta S, Mishima S, Teshima R: Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis. Int Immunopharmacol; 2010 Sep;10(9):1107-12
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  • The amount of released beta-hexosaminidase via high-affinity IgE receptor I (Fc epsilon RI) from rat basophilic leukemia (RBL-2H3) cells was used as an index of degranulation.

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  • [Copyright] (c) 2010 Elsevier B.V. All rights reserved.
  • [CommentIn] Int Immunopharmacol. 2011 Sep;11(9):1386-7 [21481329.001]
  • (PMID = 20601180.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Chemokine CCL2; 0 / Cytokines; 0 / Flavonoids; 0 / Kaempferols; 0 / Plant Extracts; 0 / Receptors, IgE; 207137-56-2 / Interleukin-4; 3CN01F5ZJ5 / chrysin; 731P2LE49E / kaempferol; 9009-62-5 / Propolis; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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59. Huelsenbeck SC, Klose I, Reichenbach M, Huelsenbeck J, Genth H: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. FEBS Lett; 2009 Oct 6;583(19):3133-9
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  • Alternative Ras antibodies including the K-Ras(Mab F234) antibody or the v-H-Ras(Mab Y13-159) antibody recognize Ras proteins regardless of glucosylation. (H/K)Ras are further shown to be more efficaciously glucosylated by TcsL than Rac1 in rat basophilic leukemia cells as well as in a cell-free system.

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  • (PMID = 19744486.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / lethal toxin LT, Clostridium sordellii; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / ras Proteins
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60. Sakai S, Sugawara T, Matsubara K, Hirata T: Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors. J Biol Chem; 2009 Oct 9;284(41):28172-9
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  • Fucoxanthin, astaxanthin, zeaxanthin, and beta-carotene significantly inhibited the antigen-induced release of beta-hexosaminidase in rat basophilic leukemia 2H3 cells and mouse bone marrow-derived mast cells.

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  • (PMID = 19700409.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Monoterpenes; 0 / Receptors, IgE; 36-88-4 / Carotenoids; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
  • [Other-IDs] NLM/ PMC2788868
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61. Chikamatsu S, Furuno T, Kinoshita Y, Inoh Y, Hirashima N, Teshima R, Nakanishi M: Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Mol Immunol; 2007 Mar;44(7):1490-7
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  • Here we have shown that Cot kinase activity is intimately involved in the high affinity receptor for IgE (FcvarepsilonRI)-mediated nuclear translocation of NF-kappaB1 independent of NF-kappaB-inducing kinase (NIK) in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17049604.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Luminescent Proteins; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / red fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.11.25 / MAP Kinase Kinase Kinases; EC 2.7.11.25 / Map3k8 protein, rat
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62. Biedermann B, Gil D, Bowen DT, Crocker PR: Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res; 2007 Feb;31(2):211-20
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  • [Title] Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.
  • CD33 (Siglec-3) is expressed on most acute myeloid leukemia (AML) cells and is currently being exploited as a therapeutic target.
  • Using primary AML cells or transfected rat basophilic leukemia cells, Siglec-9 mediated rapid endocytosis of anti-Siglec-9 mAb.
  • [MeSH-major] Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Hematopoietic Stem Cells / immunology. Lectins / analysis. Leukemia, Myeloid / immunology

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  • (PMID = 16828866.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD33 protein, human; 0 / Lectins; 0 / SIGLEC5 protein, human; 0 / SIGLEC7 protein, human; 0 / SIGLEC9 protein, human; 0 / Sialic Acid Binding Ig-like Lectin 3; 0 / Sialic Acid Binding Immunoglobulin-like Lectins
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63. Qian W, Zhang X, Li B, Zhang D, Tong Q, Chen L, Zheng L, Kou G, Wang H, Hou S, Guo Y: Development and characterization of a novel anti-IgE monoclonal antibody. Biochem Biophys Res Commun; 2010 May 14;395(4):547-52
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  • Importantly, 7A5 was able to inhibit IgE-induced histamine release of basophilic leukemia cells.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20394728.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Peptide Library; 0 / Peptides; 0 / Receptors, IgE; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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64. Hunter MJ, Iodice MW, Pathak AK, Street MA, Helm BA: Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. Mol Immunol; 2009 Mar;46(6):1260-5
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  • A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell line transfected with the alpha-chain subunit of the canine high-affinity IgE receptor using flow cytometry show that canine IgE recognizes the alpha-chain of its cognate receptor on both cell lines.

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  • (PMID = 19135724.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBSQ/Q/2005/06706
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; 37H9VM9WZL / Calcimycin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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65. Urrea Moreno R, Gil J, Rodriguez-Sainz C, Cela E, LaFay V, Oloizia B, Herr AB, Sumegi J, Jordan MB, Risma KA: Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood; 2009 Jan 8;113(2):338-46
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  • In a family affected by hemophagocytic lymphohistiocytosis, a severe inflammatory disorder caused by perforin deficiency, we identified 2 amino acid substitutions in the perforin C2 domain: T435M, a previously identified mutant with disputed pathogenicity, and Y438C, a novel substitution.
  • The capacity for cytotoxic function was tested after expression of the variant perforins in rat basophilic leukemia cells and murine cytotoxic T lymphocytes.

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  • (PMID = 18927437.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091769; United States / PHS HHS / / K12 CHILD HEALTH RESEARCH CAREER DEVELOPMENT AWARD; United States / NHLBI NIH HHS / HL / R01-HL091769
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Lipids; 126465-35-8 / Perforin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2615650
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66. Wu J, Ji C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP: FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol; 2007 Mar 15;178(6):3973-82
The Lens. Cited by Patents in .

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  • The two different alleles demonstrate significantly different FcalphaRI-mediated intracellular calcium mobilization and degranulation in rat basophilic leukemia cells and cytokine production (IL-6 and TNF-alpha) in murine macrophage P388D1 cells.

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  • (PMID = 17339498.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / P30 AR 48311; United States / NIAMS NIH HHS / AR / R01 AR 33062; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCRR NIH HHS / RR / M01 RR 00032; United States / NIAMS NIH HHS / AR / R01 AR033062; United States / NIAID NIH HHS / AI / N01 AI 40068; United States / NIAMS NIH HHS / AR / P01 AR 49084
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / IL6 protein, human; 0 / Immunoglobulin A; 0 / Interleukin-6; 0 / Receptors, Fc; 0 / Tumor Necrosis Factor-alpha
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67. Yasui Y, Nakamura M, Onda T, Uehara T, Murata S, Matsui N, Fukuishi N, Akagi R, Suematsu M, Akagi M: Heme oxygenase-1 inhibits cytokine production by activated mast cells. Biochem Biophys Res Commun; 2007 Mar 9;354(2):485-90
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  • We examined whether rat HO-1 cDNA transfected rat basophilic leukemia (RBL)-2H3 cells have altered cytokine production in response to stimulation with anti-ovalbumin (OA) serum/OA compared to Mock transfected RBL-2H3 cells.

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  • (PMID = 17234154.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Transcription Factor AP-1; EC 1.14.99.3 / Heme Oxygenase-1
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68. Haberman Y, Ziv I, Gorzalczany Y, Fukuda M, Sagi-Eisenberg R: Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment. J Cell Sci; 2005 Apr 15;118(Pt 8):1641-9

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  • However, in the rat basophilic leukemia (RBL-2H3) mast cell line, as well as in CHO cells, Syt IX is localized at the endocytic recycling compartment (ERC).

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  • (PMID = 15784685.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Enzyme Inhibitors; 0 / Phorbol Esters; 0 / Syt9 protein, rat; 134193-27-4 / Synaptotagmins; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C beta; EC 2.7.11.13 / Protein Kinase C-alpha
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69. Trinh HT, Chae SJ, Joh EH, Son KH, Jeon SJ, Kim DH: Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol; 2010 Oct 28;132(1):344-8
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  • Protein expression of IL-4 and TNF-α in rat basophilic leukemia (RBL)-2H3 cells was performed by enzyme-linked immunosorbent assay and NF-κB and c-jun (AP-1) activation assayed by immunoblot.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20732401.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Diterpenes, Abietane; 0 / Drugs, Chinese Herbal; 0 / NF-kappa B; 0 / Phenanthrenes; 0 / Proto-Oncogene Proteins c-jun; 0 / Salvia extract; 0 / Tumor Necrosis Factor-alpha; 03UUH3J385 / tanshinone; 207137-56-2 / Interleukin-4
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70. Chang KP, Lai CH, Huang SH, Tai HT, Chang LL, Lin SD, Hwang SL, Lai CS: Downregulation of Janus kinase 3 expression by small interfering RNA in rat composite tissue allotransplantation. Transpl Immunol; 2009 May;21(1):27-32
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  • The expression vector containing the pre-mRNA expression cassette was transfected into rat basophilic leukemia cell line, RBL-2H3, for RNAi analysis (in vitro).

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  • (PMID = 19233270.001).
  • [ISSN] 1878-5492
  • [Journal-full-title] Transplant immunology
  • [ISO-abbreviation] Transpl. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Jak3 protein, rat; 0 / RNA, Small Interfering; EC 2.7.10.2 / Janus Kinase 3
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71. Kim K, Kim Y, Kim HY, Ro JY, Jeoung D: Inhibitory mechanism of anti-allergic peptides in RBL2H3 cells. Eur J Pharmacol; 2008 Feb 26;581(1-2):191-203
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  • Likewise, the peptides inhibited the release of beta-hexosaminidase from antigen-stimulated rat basophilic leukemia (RBL2H3) cells and decreased calcium influx and intracellular reactive oxygen species production as well.

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  • (PMID = 18078925.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Peptide Library; 0 / Peptides; 0 / Reactive Oxygen Species; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; SY7Q814VUP / Calcium
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72. Seo M, Ikeda K, Okamura T, Kida K, Satoh M, Inagaki N, Nagai H, Nagase H: Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production. Toxicology; 2008 Jan 14;243(1-2):75-83

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  • Non-purified rat peritoneal mast cells (NPMC) and rat basophilic leukemia (RBL-2H3) cells were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody, and then stimulated with DNP-conjugated bovine serum albumin (DNP-BSA) and several chlorinated organic solvents.

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  • (PMID = 18006135.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Dinitrophenols; 0 / Hydrocarbons, Chlorinated; 0 / Inflammation Mediators; 0 / Serum Albumin, Bovine; 0 / Solvents; 0 / dinitrophenyl-bovine serum albumin
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73. El-Sibai M, Backer JM: Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells. Eur J Immunol; 2007 Jan;37(1):261-70
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  • In this study, we examine the kinetics and mechanism of Rac and Cdc42 activation in the rat basophilic leukemia RBL-2H3 cells.

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  • (PMID = 17163445.001).
  • [ISSN] 0014-2980
  • [Journal-full-title] European journal of immunology
  • [ISO-abbreviation] Eur. J. Immunol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA100324
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens; 0 / Enzyme Inhibitors; 0 / Estrenes; 0 / Pyrrolidinones; 112648-68-7 / 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; EC 3.1.4.3 / Phospholipase C gamma; EC 3.6.5.2 / cdc42 GTP-Binding Protein; EC 3.6.5.2 / rac GTP-Binding Proteins; SY7Q814VUP / Calcium
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74. Csutora P, Zarayskiy V, Peter K, Monje F, Smani T, Zakharov SI, Litvinov D, Bolotina VM: Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway. J Biol Chem; 2006 Nov 17;281(46):34926-35
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  • Here we tested the role of calcium influx factor (CIF) and calcium-independent phospholipase A2 (iPLA2) in activation of Ca2+ release-activated Ca2+ (CRAC) channels and store-operated Ca2+ entry in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17003039.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL54150; United States / NHLBI NIH HHS / HL / HL71793
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Carrier Proteins; EC 3.1.1.- / Phospholipases A; EC 3.1.1.4 / Group IV Phospholipases A2; EC 3.1.1.4 / Phospholipases A2; SY7Q814VUP / Calcium
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75. Ferreres F, Pereira DM, Gil-Izquierdo A, Valentão P, Botelho J, Mouga T, Andrade PB: HPLC-PAD-atmospheric pressure chemical ionization-MS metabolite profiling of cytotoxic carotenoids from the echinoderm Marthasterias glacialis (spiny sea-star). J Sep Sci; 2010 Aug;33(15):2250-7
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  • The purified carotenoid fraction displayed a strong cell proliferation inhibition against rat basophilic leukemia RBL-2H3 (IC(25)=268 microg/mL) cancer cell line.

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  • (PMID = 20574958.001).
  • [ISSN] 1615-9314
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 36-88-4 / Carotenoids
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76. Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T: Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol; 2010 Jul;10(7):769-76
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  • We examined the effects of Lico A and related chalcones on degranulation in a rat basophilic leukemia cell line, RBL-2H3.

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  • Hazardous Substances Data Bank. L-TYROSINE .
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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399908.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Chalcones; 42HK56048U / Tyrosine; 58749-22-7 / licochalcone A; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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77. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y: Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol; 2010 Sep;32(3):454-61
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  • To investigate the antiallergic effects of fermented grape marc from Negroamaro (N-FGM), we examined antigen (Ag)-induced degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Antigens / immunology. Basophil Degranulation Test. Fermentation. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein-Tyrosine Kinases / metabolism. Rats. Syk Kinase. Tumor Cells, Cultured

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  • (PMID = 20100066.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/ BB/D008123/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 37341-29-0 / Immunoglobulin E; 9IKM0I5T1E / Quercetin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Syk Kinase; EC 2.7.10.2 / Syk protein, rat
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78. Lim H, Son KH, Bae KH, Hung TM, Kim YS, Kim HP: 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. Phytother Res; 2009 Oct;23(10):1489-92
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  • The compounds including schizandrins, schisandrols, gomisins, fargesin, eudesmin and lirioresinol B dimethyl ether, inhibited 5-LOX-catalysed leukotriene production from A23187-treated rat basophilic leukemia (RBL-1) cells at concentrations of 1-100 microm.

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  • [Copyright] (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19277963.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Cyclooctanes; 0 / Leukotrienes; 0 / Lignans; 0 / Lipoxygenase Inhibitors; 0 / Plant Extracts; 0 / schisandrol A; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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79. Jensen BM, Swindle EJ, Iwaki S, Gilfillan AM: Generation, isolation, and maintenance of rodent mast cells and mast cell lines. Curr Protoc Immunol; 2006 Sep;Chapter 3:Unit 3.23
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  • In addition to human mast cells, the major cell culture systems employed to investigate these responses are rat and mouse peritoneal mast cells, mouse bone-marrow-derived mast cells, the rat basophilic leukemia cell line RBL-2H3, and the mouse MC/9 mast cell line.

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  • (PMID = 18432974.001).
  • [ISSN] 1934-368X
  • [Journal-full-title] Current protocols in immunology
  • [ISO-abbreviation] Curr Protoc Immunol
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / ZIA AI000965-04; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
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80. Rettig JR, Folch A: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem; 2005 Sep 1;77(17):5628-34
The Lens. Cited by Patents in .

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  • We have characterized microwell occupancy by cells for a range of microwell dimensions and seeding parameters and optimized it for fibroblasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cell).

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  • (PMID = 16131075.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R21DC006465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Liu-Bryan R, Pay S, Schraufstatter IU, Rose DM: The CXCR1 tail mediates beta1 integrin-dependent cell migration via MAP kinase signaling. Biochem Biophys Res Commun; 2005 Jun 24;332(1):117-25
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  • We assessed individual contributions of signaling by IL-8 receptors by transfection of CXCR1 and CXCR2 into rat basophilic leukemia (RBL) cells and human monocytic THP-1 cells.

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  • (PMID = 15896307.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL55657; United States / NIAMS NIH HHS / AR / P30AR47360; United States / NIAMS NIH HHS / AR / R03AR49416
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Interleukin-8; 0 / Receptors, Interleukin-8A; 0 / Receptors, Interleukin-8B; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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82. Cho Y, Jang Y, Yang YD, Lee CH, Lee Y, Oh U: TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium; 2010 Oct;48(4):202-8
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  • Here, we report that TRPM8 is expressed in the basophilic leukemia mast cell line, RBL-2H3, and that exposure to menthol or low temperatures induced Ca(2+) influx in RBL-2H3 cells, which was reversed by a TRPM8 blocker.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20934218.001).
  • [ISSN] 1532-1991
  • [Journal-full-title] Cell calcium
  • [ISO-abbreviation] Cell Calcium
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Fluorescent Dyes; 0 / RNA, Small Interfering; 0 / TRPM Cation Channels; 0 / Xanthenes; 121714-13-4 / Fluo-3; 1490-04-6 / Menthol; SY7Q814VUP / Calcium
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83. Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K: Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. Peptides; 2010 Nov;31(11):2109-13

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  • Rat peritoneal mast cells and rat basophilic leukemia (RBL-2H3) cells did not express the ghrelin receptor GHSR1a, suggesting that histamine release induced by ghrelin occurs via a receptor-independent mechanism.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20691233.001).
  • [ISSN] 1873-5169
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones; 0 / Receptors, Ghrelin; 0 / obestatin, rat; EC 2.4.2.31 / Pertussis Toxin
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84. Jolly PS, Bektas M, Watterson KR, Sankala H, Payne SG, Milstien S, Spiegel S: Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood; 2005 Jun 15;105(12):4736-42
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  • Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degranulation as well as migration toward antigen.

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  • (PMID = 15741218.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AIS0094; United States / NCI NIH HHS / CA / P30 CA16059
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Culture Media, Serum-Free; 0 / Ligands; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / Receptors, Lysosphingolipid; 37341-29-0 / Immunoglobulin E; 37589-80-3 / Guanosine 5'-O-(3-Thiotriphosphate); EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunit, Gi2; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; EC 3.6.5.1 / Gnai2 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC1894993
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85. Chandrasekaran CV, Gupta A, Agarwal A: Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol; 2010 May 27;129(2):203-7
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  • MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20307638.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Plant Extracts; 1HGW4DR56D / Leukotriene B4; 37H9VM9WZL / Calcimycin
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86. Edel JB, Wu M, Baird B, Craighead HG: High spatial resolution observation of single-molecule dynamics in living cell membranes. Biophys J; 2005 Jun;88(6):L43-5
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  • In this letter we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled cell membrane component on a surface containing zero-mode waveguides (ZMWs).

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  • (PMID = 15821167.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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87. Ishihara Y, Furuno T, Nakanishi M: The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells. Inflamm Res; 2006 Nov;55(11):465-8
Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .

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  • OBJECTIVE AND DESIGN: We have studied the role of phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) in activation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-major] Calcium Signaling / physiology. Cell Degranulation / physiology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / physiopathology. Phosphotransferases (Alcohol Group Acceptor) / physiology

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  • (PMID = 17122963.001).
  • [ISSN] 1023-3830
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens; 0 / RNA, Messenger; 0 / Receptors, IgE; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.67 / phosphatidylinositol phosphate 4-kinase
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88. Huang YF, Liu H, Xiong X, Chen Y, Tan W: Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells. J Am Chem Soc; 2009 Dec 2;131(47):17328-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We found that both nanoparticle size and surface ligand density play key regulatory roles in the process of membrane antibody-receptor (IgE-Fc epsilonRI) binding and cross-linking, which, in turn, leads to degranulation and consequent release of chemical mediators on rat basophilic leukemia cells.

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  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM079359; United States / NIGMS NIH HHS / GM / R01 GM079359-01; None / None / / R01 GM079359-01; United States / NIGMS NIH HHS / GM / R01 GM079359-02; United States / NIGMS NIH HHS / GM / R01 GM079359-03; None / None / / R01 GM079359-02; None / None / / R01 GM079359-01S1; United States / NIGMS NIH HHS / GM / R01 GM079359-01S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
  • [Other-IDs] NLM/ NIHMS158340; NLM/ PMC2786779
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89. Ohga K, Takezawa R, Yoshino T, Yamada T, Shimizu Y, Ishikawa J: The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo. Pulm Pharmacol Ther; 2008;21(2):360-9
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  • YM-58483 inhibited DNP antigen-induced histamine release from and leukotrienes (LTs) production in IgE-primed RBL-2H3 cells, a rat basophilic leukemia cell line, with IC50 values of 460 and 310 nM, respectively.

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  • (PMID = 17977764.001).
  • [ISSN] 1094-5539
  • [Journal-full-title] Pulmonary pharmacology & therapeutics
  • [ISO-abbreviation] Pulm Pharmacol Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide; 0 / Anilides; 0 / Anti-Inflammatory Agents; 0 / Calcium Channel Blockers; 0 / Dinitrophenols; 0 / Leukotrienes; 0 / Phytohemagglutinins; 0 / Serum Albumin, Bovine; 0 / Thiadiazoles; 0 / dinitrophenyl-bovine serum albumin; 0 / phytohemagglutinin-P; 9006-59-1 / Ovalbumin; 9PHQ9Y1OLM / Prednisolone; SY7Q814VUP / Calcium
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90. Tapper H, Källquist L, Johnsson E, Persson AM, Hansson M, Olsson I: Neutrophil elastase sorting involves plasma membrane trafficking requiring the C-terminal propeptide. Exp Cell Res; 2006 Nov 1;312(18):3471-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we investigated the role of the C-terminal pro-peptide in trafficking of NE by expressing, in rat basophilic leukemia (RBL) cells, both wild-type NE and the mutant NE/Delta248-267, which lacks the C-terminal pro-peptide.

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  • (PMID = 16950244.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Peptides; 0 / Protein Precursors; EC 3.4.21.37 / Leukocyte Elastase
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91. Risma KA, Frayer RW, Filipovich AH, Sumegi J: Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest; 2006 Jan;116(1):182-92
SciCrunch. OMIM: Data: Gene Annotation .

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  • We have shown, for the first time to our knowledge, that recombinant human perforin is expressed, processed appropriately, and functional in rat basophilic leukemia (RBL) cells following retroviral transduction.

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  • (PMID = 16374518.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD043005; United States / NICHD NIH HHS / HD / T32 HD43005-02B
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Pore Forming Cytotoxic Proteins; 126465-35-8 / Perforin
  • [Other-IDs] NLM/ PMC1319223
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92. Sonnenblick A, Levy C, Razin E: Immunological trigger of mast cells by monomeric IgE: effect on microphthalmia transcription factor, STAT3 network of interactions. J Immunol; 2005 Aug 1;175(3):1450-5
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • In this work, we show for the first time that, in mouse bone marrow-derived mast cells and in rat basophilic leukemia cells, monomeric IgE alone can induce the MITF-protein inhibitor of activated STAT3-STAT3 network of interactions and leads to phosphorylation of MITF at S73 and of STAT3 at both tyrosine 705 and S727.

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  • (PMID = 16034081.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mitf protein, mouse; 0 / Mitf protein, rat; 0 / Pias3 protein, mouse; 0 / Protein Inhibitors of Activated STAT; 0 / STAT3 Transcription Factor; 0 / Stat3 protein, mouse; 0 / Stat3 protein, rat; 0 / Trans-Activators; 0 / Transcription Factors; 37341-29-0 / Immunoglobulin E; EC 1.13.12.- / Luciferases
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93. Naveen B, Shankar BS, Subrahmanyam G: FcepsilonRI cross-linking activates a type II phosphatidylinositol 4-kinase in RBL 2H3 cells. Mol Immunol; 2005 Aug;42(12):1541-9
Hazardous Substances Data Bank. CHOLESTEROL .

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  • Crosslinking of FcepsilonRI on rat basophilic leukemia (RBL 2H3) cells leads to an increase in Phosphatidylinositol 4-kinase activity.

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  • (PMID = 15950747.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Receptors, IgE; 0 / Stilbenes; 0 / beta-Cyclodextrins; 0 / methyl-beta-cyclodextrin; 97C5T2UQ7J / Cholesterol; EC 2.7.1.67 / 1-Phosphatidylinositol 4-Kinase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; Q369O8926L / resveratrol
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94. Ye N, Wang MW, Qin J, Lin B: Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells. Biomed Microdevices; 2010 Jun;12(3):513-21
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  • This work proposed a microfluidic-based method to characterize FPR-related cellular events in response to small peptides, N-formyl-Met-Leu-Phe (fMLF), in rat basophilic leukemia cell line RBL-2H3 expressing human FPR (RBL-FPR).
  • [MeSH-major] Drug Evaluation, Preclinical / instrumentation. Immunoassay / instrumentation. Leukemia, Basophilic, Acute / immunology. Microfluidic Analytical Techniques / instrumentation. Protein Interaction Mapping / instrumentation. Receptors, Formyl Peptide / drug effects. Receptors, Formyl Peptide / immunology

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  • (PMID = 20195765.001).
  • [ISSN] 1572-8781
  • [Journal-full-title] Biomedical microdevices
  • [ISO-abbreviation] Biomed Microdevices
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Formyl Peptide
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95. Morikawa T, Xu F, Matsuda H, Yoshikawa M: Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus. Chem Pharm Bull (Tokyo); 2010 Oct;58(10):1379-85
The Lens. Cited by Patents in .

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  • Among the isolates, longusol B (IC(50)=96 µM), luteolin (3.0 µM), resveratrol (17 µM), piceatannol (24 µM), and cassigarols E (84 µM) and G (84 µM) were found to inhibit the release of β-hexosaminidase, as a marker of antigen-induced degranulations, in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 20930408.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Free Radical Scavengers; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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96. Baumann MJ, Eggel A, Amstutz P, Stadler BM, Vogel M: DARPins against a functional IgE epitope. Immunol Lett; 2010 Oct 30;133(2):78-84
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  • Furthermore, anti-IgE DARPins were shown to inhibit proinflammatory mediator release from rat basophilic leukemia cells expressing human high-affinity IgE receptors with higher efficacy than the monoclonal anti-IgE antibody omalizumab.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673836.001).
  • [ISSN] 1879-0542
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / DARPin E2 79; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin Constant Regions; 0 / Recombinant Fusion Proteins; 2P471X1Z11 / Omalizumab; 37341-29-0 / Immunoglobulin E
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97. Haberman Y, Ziv I, Gorzalczany Y, Hirschberg K, Mittleman L, Fukuda M, Sagi-Eisenberg R: Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells. Blood; 2007 Apr 15;109(8):3385-92
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  • We now show that synaptotagmin (Syt) IX, a Syt homologue that is required for recycling from the endocytic recycling compartment (ERC) in rat basophilic leukemia (RBL-2H3) cultured mast cells, is involved in segregating recycling proteins from the SGs.

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  • (PMID = 17164344.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex 1; 0 / Membrane Glycoproteins; 0 / Tgoln2 protein, rat; 134193-27-4 / Synaptotagmins; EC 3.6.5.2 / ADP-Ribosylation Factor 1
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98. Koumura T, Nakamura C, Nakagawa Y: Role of calcium-induced mitochondrial hydroperoxide in induction of apoptosis of RBL2H3 cells with eicosapentaenoic acid treatment. Free Radic Res; 2005 Oct;39(10):1083-9
Hazardous Substances Data Bank. HYDROGEN PEROXIDE .

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  • Eicosapentaenoic acid (EPA) was previously shown to induce caspase-independent apoptosis in rat basophilic leukemia cells (RBL2H3 cells) by translocation of apoptosis-inducing factor (AIF) [Free Radic Res (2005) 39, 225-235].

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  • (PMID = 16298733.001).
  • [ISSN] 1071-5762
  • [Journal-full-title] Free radical research
  • [ISO-abbreviation] Free Radic. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 11103-72-3 / Ruthenium Red; 139890-68-9 / 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; 526U7A2651 / Egtazic Acid; 9007-43-6 / Cytochromes c; AAN7QOV9EA / Eicosapentaenoic Acid; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.12 / phospholipid-hydroperoxide glutathione peroxidase; EC 1.11.1.9 / Glutathione Peroxidase; SY7Q814VUP / Calcium
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99. Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M: Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation. Bioorg Med Chem; 2010 Aug 15;18(16):5932-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among the isolated compounds, linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) exhibited antigen (Ag)-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20663674.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 0 / Phenols; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase
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100. Nugroho AE, Ikawati Z, Sardjiman, Maeyama K: Effects of benzylidenecyclopentanone analogues of curcumin on histamine release from mast cells. Biol Pharm Bull; 2009 May;32(5):842-9
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the present study, fourteen benzylidenecyclopentanone analogues of curcumin were studied for their effects on histamine release from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 19420752.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzylidene Compounds; 0 / Cyclopentanes; 220W81TN3S / cyclopentanone; IT942ZTH98 / Curcumin; SY7Q814VUP / Calcium
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