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1. Zhou Y, Chen Z, He S: Preparation, characterization and epitope mapping of monoclonal antibodies specific to human mast cell carboxypeptidase. Scand J Immunol; 2006 Nov;64(5):564-70
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  • Flow cytometry analysis shows that basophilic leukemia cell line KU812 reacts with both CCP1 and CCP2 antibodies, suggesting that this cell line expresses hMC-CP.

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  • (PMID = 17032250.001).
  • [ISSN] 0300-9475
  • [Journal-full-title] Scandinavian journal of immunology
  • [ISO-abbreviation] Scand. J. Immunol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; EC 3.4.- / Carboxypeptidases
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2. Voskoboinik I, Thia MC, Trapani JA: A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood; 2005 Jun 15;105(12):4700-6
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  • In this study, we expressed wild-type and mutated perforin in rat basophil leukemia cells to study the effect on lytic function of the substitutions A91V and N252S (commonly considered to be neutral polymorphisms) and 22 perforin missense substitutions first identified in HLH patients.


3. Thors L, Eriksson J, Fowler CJ: Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake. Br J Pharmacol; 2007 Nov;152(5):744-50
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  • BACKGROUND AND PURPOSE: Genistein, a tyrosine kinase inhibitor used to block caveolae dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 17676056.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / DA009789-12A17961; United States / NIDA NIH HHS / DA / P01 DA009789; United States / NIDA NIH HHS / DA / P01 DA009789-12A17961
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Isoflavones; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 10028-17-8 / Tritium; 6287WC5J2L / daidzein; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2190009
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4. Shin SY, Koo SH, Kwon KC, Park JW, Ko CS, Jo DY: Monosomy 7 as the sole abnormality of an acute basophilic leukemia. Cancer Genet Cytogenet; 2007 Jan 15;172(2):168-71
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  • [Title] Monosomy 7 as the sole abnormality of an acute basophilic leukemia.
  • We report the case of a 72-year-old man who had the very rare disease acute basophilic leukemia with the sole chromosomal finding of a monosomy 7.
  • Electron microscopic evaluation showed the typical ultrastructure, with basophil and immature mast cell granules.
  • To our knowledge, the case reported here is the first to have basophilic leukemia with monosomy 7 as the only chromosome abnormality.
  • [MeSH-major] Chromosomes, Human, Pair 7 / genetics. Leukemia, Basophilic, Acute / genetics. Monosomy / diagnosis. Monosomy / genetics

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  • (PMID = 17213028.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Blonski WC, Katzka DA, Lichtenstein GR, Metz DC: Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Apr;17(4):441-4
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  • [Title] Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease.
  • Many gastric acid hypersecretory states (basal acid output of greater than 15.0 mEq/h) exist for which the etiology is known, such as Zollinger-Ellison syndrome, systemic mastocytosis, antral exclusion, antral predominant Helicobacter pylori gastritis (antral G cell hyperplasia), chronic gastric outlet obstruction, short gut syndrome and basophilic leukemias.

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Dec;17(12):1433 [16292103.001]
  • [CommentIn] Eur J Gastroenterol Hepatol. 2005 Sep;17(9):1001 [16093882.001]
  • (PMID = 15756097.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Gastrins; KG60484QX9 / Omeprazole
  • [Number-of-references] 28
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6. Knipping K, van Esch EC, Wijering SC, van der Heide S, Dubois AE, Garssen J: In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood); 2008 Nov;233(11):1469-77
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  • AL was selected out of 10,000 herbal extracts in a set-up for high throughput screening in which the degree of degranulation was monitored by the release of beta-hexosaminidase from rat basophil leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Basophils / drug effects. Basophils / metabolism. Chemical Fractionation. Chromatography, High Pressure Liquid. Ear Diseases / chemically induced. Ear Diseases / drug therapy. Edema / chemically induced. Edema / drug therapy. Humans. Leukocytes, Mononuclear / drug effects. Leukocytes, Mononuclear / metabolism. Leukotrienes / biosynthesis. Mice. Rats

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  • (PMID = 18703753.001).
  • [ISSN] 1535-3702
  • [Journal-full-title] Experimental biology and medicine (Maywood, N.J.)
  • [ISO-abbreviation] Exp. Biol. Med. (Maywood)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Anti-Inflammatory Agents; 0 / Leukotrienes; 0 / Plant Extracts
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7. Parusel I, Kahl S, Braasch F, Glowacki G, Halverson GR, Reid ME, Schawalder A, Ortolan E, Funaro A, Malavasi F, Hardie D, Halder S, Buckley CD, Haag F, Koch-Nolte F: A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cell Immunol; 2005 Jul-Aug;236(1-2):59-65
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  • The mAbs reacted weakly also with human umbilical vein endothelial cells and the basophilic leukemia KU-812.

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  • (PMID = 16168396.001).
  • [ISSN] 0008-8749
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL54459
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cell Cycle Proteins; 0 / GML protein, human; 0 / GPI-Linked Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / ART4 protein, human
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8. Lichtman MA, Segel GB: Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review. Blood Cells Mol Dis; 2005 Nov-Dec;35(3):370-83
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  • [Title] Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.
  • The potential of the transformed (leukemic) multipotential hematopoietic cell to differentiate and mature along any myeloid lineage forms the basis for the phenotypic classification of acute and chronic myelogenous leukemia.
  • Although most cases of leukemia can be classified phenotypically by the dominant lineage expressed, the genotype within each phenotype is heterogeneous.
  • The least common AML phenotypes are a reflection of the least common blood or marrow cell lineages: acute basophilic, acute mast cell, acute eosinophilic, and acute myeloid dendritic cell leukemia.
  • [MeSH-major] Basophils / pathology. Dendritic Cells / pathology. Eosinophils / pathology. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Acute / pathology. Mast Cells / pathology. Myeloid Cells / pathology


9. Staal-Viliare A, Latger-Cannard V, Rault JP, Didion J, Grégoire MJ, Bologna S, Witz B, Jonveaux P, Lecompte T, Rio Y: [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature]. Ann Biol Clin (Paris); 2006 Jul-Aug;64(4):361-5
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  • [Title] [A case of de novo acute basophilic leukaemia: diagnostic criteria and review of the literature].
  • [Transliterated title] A propos d'un cas de leucémie à basophiles de novo: critères diagnostiques et revue de la littérature.
  • We report a case of a de novo acute basophilic leukaemia, revealed by an infectious pneumopathy in a 73 year old man.
  • The blood and bone marrow smears showed a mixture of undifferentiated blast cells and basophiloblasts (high nucleo-cytoplasmic ratio, coarse basophilic cytoplasmic granules), along with basophilic precursors and basophilic polymorphonuclears.
  • All the blasts were MPO negative but positive for the toluidine blue metachromatic coloration, which is considered as consistent with basophilic lineage.
  • Immunophenotypic studies showed myeloid blasts, without maturity marker, CD 117 negative and CD203 cytoplasmic positive, the latter known to be highly representative of the basophilic lineage.
  • This very clear-cut phenotype, associated with the morphology of cells, were arguments to ascertain the basophilic lineage of the blasts without the need of electron microscopic study.
  • This clinical prompted allows us to review the literature on acute basophilic leukaemia and to state on the different diagnostic criteria of this rare disorder.
  • [MeSH-major] Leukemia, Basophilic, Acute / blood. Leukemia, Basophilic, Acute / diagnosis

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  • (PMID = 16829481.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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10. Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM: Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. J Natl Cancer Inst; 2005 Jun 1;97(11):823-35
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  • Endogenous FPR agonist activity released by necrotic tumor cells was assessed by measuring FPR activation in an FPR-transfected basophil leukemia cell line and live U-87 cells.

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  • (PMID = 15928303.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 0 / Receptors, Formyl Peptide; 0 / Vascular Endothelial Growth Factor A
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11. Ljubić N, Lang N, Skelin IK, Lasan R, Dominis M, Perković L, Zupanić-Krmek D, Grgurević-Batinica A: Klinefelter syndrome and acute basophilic leukaemia--case report. Coll Antropol; 2010 Jun;34(2):657-60
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  • [Title] Klinefelter syndrome and acute basophilic leukaemia--case report.
  • Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia.
  • We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells.
  • Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias.
  • Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules.
  • There is no consistent chromosomal abnormality identified in this leukaemia.
  • This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome.
  • In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
  • [MeSH-major] Klinefelter Syndrome / complications. Leukemia, Basophilic, Acute / complications

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  • (PMID = 20698148.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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12. Linhart B, Bigenzahn S, Hartl A, Lupinek C, Thalhamer J, Valenta R, Wekerle T: Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol; 2007 Mar 15;178(6):3924-31
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  • Immediate-type reactions as analyzed by a rat basophil leukemia cell mediator release assay were only suppressed by early treatment but not by a costimulation blockade after sensitization.

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  • (PMID = 17339493.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / F 2310
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Immunoconjugates; 0 / Immunosuppressive Agents; 0 / PHLPII protein, Phleum pratense; 0 / Phl p V protein, Phleum pratense; 0 / Plant Proteins; 147205-72-9 / CD40 Ligand; 37341-29-0 / Immunoglobulin E; 7D0YB67S97 / Abatacept
  • [Other-IDs] NLM/ PMC2993922; NLM/ UKMS32950
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13. Tefferi A, Elliott MA, Pardanani A: Atypical myeloproliferative disorders: diagnosis and management. Mayo Clin Proc; 2006 Apr;81(4):553-63
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  • The World Health Organization system for classification of tumors of the hematopoietic system divides myeloid disorders into acute myeloid leukemia and chronic myeloid disorders based on the presence or absence, respectively, of acute myeloid leukemia--defining morphological and cytogenetic features including the presence of 20% or more myeloblasts in either the bone marrow or the peripheral blood.
  • Classic MPD includes polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, and chronic myeloid leukemia.
  • The current review focuses on the diagnosis and treatment of both molecularly defined and clinicopathologically assigned categories of atypical MPD: chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, chronic neutrophilic leukemia, chronic basophilic leukemia, chronic eosinophilic leukemia, idiopathic eosinophilia including hypereosinophilic syndrome, systemic mastocytosis, unclassified MPD, and eosinophilic/mast cell disorders associated with mutations of platelet-derived growth factor receptors alpha (PDGFRA) and beta (PDGFRB), FGFR1, and KIT.

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  • (PMID = 16610578.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 173
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14. Thors L, Belghiti M, Fowler CJ: Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. Br J Pharmacol; 2008 Sep;155(2):244-52
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  • All three compounds reduced the FAAH-dependent uptake of anandamide and its metabolism by intact RBL2H3 basophilic leukaemia cells.

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  • (PMID = 18552875.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Kaempferols; 0 / Polyunsaturated Alkamides; 731P2LE49E / kaempferol; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2538700
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15. Mizuno H, Tsuyama N, Date S, Harada T, Masujima T: Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell. Anal Sci; 2008 Dec;24(12):1525-7
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  • [Title] Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell.
  • The metabolic pathways and the locations of tryptophan and histidine metabolites were traced by this method for a cultured rat basophil leukemia cell line (RBL-2H3).
  • [MeSH-major] Basophils / metabolism. Basophils / pathology. Histidine / metabolism. Leukemia / metabolism. Leukemia / pathology. Metabolomics. Tryptophan / metabolism

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  • (PMID = 19075459.001).
  • [ISSN] 1348-2246
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 4QD397987E / Histidine; 8DUH1N11BX / Tryptophan
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16. Schulmeister U, Hochwallner H, Swoboda I, Focke-Tejkl M, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Keller W, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, Valenta R, Spitzauer S: Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen. J Immunol; 2009 Jun 1;182(11):7019-29
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  • The allergenic activity of ralphaS1-casein and the alphaS1-casein-derived peptides was determined using rat basophil leukemia cells transfected with human FcepsilonRI, which had been loaded with the patients' serum IgE.
  • Our results demonstrate that ralphaS1-casein as well as alphaS1-casein-derived peptides exhibit IgE reactivity, but mainly the intact ralphaS1-casein induced strong basophil degranulation.

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  • (PMID = 19454699.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / DNA, Complementary; 0 / Epitopes; 0 / Peptide Fragments; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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17. Qian W, Zhang X, Li B, Zhang D, Tong Q, Chen L, Zheng L, Kou G, Wang H, Hou S, Guo Y: Development and characterization of a novel anti-IgE monoclonal antibody. Biochem Biophys Res Commun; 2010 May 14;395(4):547-52
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  • Importantly, 7A5 was able to inhibit IgE-induced histamine release of basophilic leukemia cells.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20394728.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Peptide Library; 0 / Peptides; 0 / Receptors, IgE; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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18. Li Y, Lee SH, Le QT, Kim MM, Kim SK: Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI. J Agric Food Chem; 2008 Dec 24;56(24):12073-80
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  • In this study, anti-allergic activities of phloroglucinol derivatives were assessed on human basophilic leukemia (KU812) and rat basophilic leukemia (RBL-2H3) cell lines using a histamine release assay.

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  • (PMID = 19053379.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Plant Extracts; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; DHD7FFG6YS / Phloroglucinol
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19. Gadermaier G, Jahn-Schmid B, Vogel L, Egger M, Himly M, Briza P, Ebner C, Vieths S, Bohle B, Ferreira F: Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol; 2010 Mar;47(6):1292-8
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  • Mediator release assays using rat basophil leukemia cells showed that these variants displayed a 1x10(5)-fold reduced allergenic potency as compared to wild-type protein.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20022115.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 20011
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies; 0 / Antigens, Plant; 0 / Art v 1 protein, mugwort; 0 / Mutant Proteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; K848JZ4886 / Cysteine
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20. Marazuela EG, Rodríguez R, Barber D, Villalba M, Batanero E: Hypoallergenic mutants of Ole e 1, the major olive pollen allergen, as candidates for allergy vaccines. Clin Exp Allergy; 2007 Feb;37(2):251-60
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  • Their allergenicity was also investigated in both a mouse model of allergic sensitization and in basophil activation assays.
  • Rat basophil leukaemia assays identified the deletion mutant 135Delta10 as the variant with the lowest beta-hexosaminidase-releasing capacity.

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  • (PMID = 17250698.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Ole e I protein, Olea europaea; 0 / Plant Proteins; 0 / Vaccines, Synthetic
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21. Linhart B, Hartl A, Jahn-Schmid B, Verdino P, Keller W, Krauth MT, Valent P, Horak F, Wiedermann U, Thalhamer J, Ebner C, Kraft D, Valenta R: A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol; 2005 May;115(5):1010-6
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  • Immune responses to the hybrid molecule were studied in BALB/c mice and rat basophil leukemia assays.
  • IgG antibodies induced by vaccination with the hybrid blocked immediate allergic reactions, as demonstrated by rat basophil degranulation assays in a murine model of grass pollen allergy.

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  • (PMID = 15867859.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin G; 0 / Recombinant Fusion Proteins; 0 / Vaccines; 0 / Vaccines, DNA
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22. Cho Y, Jang Y, Yang YD, Lee CH, Lee Y, Oh U: TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium; 2010 Oct;48(4):202-8
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  • Here, we report that TRPM8 is expressed in the basophilic leukemia mast cell line, RBL-2H3, and that exposure to menthol or low temperatures induced Ca(2+) influx in RBL-2H3 cells, which was reversed by a TRPM8 blocker.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20934218.001).
  • [ISSN] 1532-1991
  • [Journal-full-title] Cell calcium
  • [ISO-abbreviation] Cell Calcium
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Fluorescent Dyes; 0 / RNA, Small Interfering; 0 / TRPM Cation Channels; 0 / Xanthenes; 121714-13-4 / Fluo-3; 1490-04-6 / Menthol; SY7Q814VUP / Calcium
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23. Lessmann E, Leitges M, Huber M: A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol; 2006 May;18(5):767-73
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  • A critical role of PKC-epsilon in antigen-triggered activation of various signaling pathways was observed in basophilic leukemia cells.


24. Borges JP, Culerrier R, Aldon D, Barre A, Benoist H, Saurel O, Milon A, Didier A, Rougé P: GATEWAY technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3). Protein Expr Purif; 2010 Apr;70(2):277-82
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  • The reactivity of rMal d 3 towards IgE from apple allergic patients and in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits.

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  • [Copyright] (c) 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19778615.001).
  • [ISSN] 1096-0279
  • [Journal-full-title] Protein expression and purification
  • [ISO-abbreviation] Protein Expr. Purif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Carrier Proteins; 0 / Mal d 3 allergen; 0 / Recombinant Proteins; 0 / lipid transfer protein
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25. Nowak-Wegrzyn AH, Bencharitiwong R, Schwarz J, David G, Eggleston P, Gergen PJ, Liu AH, Pongracic JA, Sarpong S, Sampson HA: Mediator release assay for assessment of biological potency of German cockroach allergen extracts. J Allergy Clin Immunol; 2009 Apr;123(4):949-955.e1
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  • OBJECTIVE: We investigated the utility of a mediator release assay based on rat basophil leukemia (RBL) cells for comparing the potency of German cockroach extracts.

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  • (PMID = 19348929.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / K23 AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25482; United States / NIAID NIH HHS / AI / N01 AI025496; United States / NIAID NIH HHS / AI / AI 059318; United States / NIAID NIH HHS / AI / N01AI25496; United States / NIAID NIH HHS / AI / N01 AI025482; United States / NIAID NIH HHS / AI / K23 AI059318; United States / NIAID NIH HHS / AI / N01AI25482; United States / NIAID NIH HHS / AI / AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25496
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 3.2.1.- / Hexosaminidases
  • [Other-IDs] NLM/ NIHMS109184; NLM/ PMC2952833
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26. Fowler CJ, Ghafouri N: Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? Pharmacol Res; 2008 Jul;58(1):72-6
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  • The selective fatty acid amide hydrolase inhibitor URB597 (3'-(aminocarbamoyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate) completely blocked the hydrolysis of anandamide and reduced its uptake by about half in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 18675915.001).
  • [ISSN] 1043-6618
  • [Journal-full-title] Pharmacological research
  • [ISO-abbreviation] Pharmacol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Biphenyl Compounds; 0 / Cannabinoid Receptor Modulators; 0 / Carbamates; 0 / Endocannabinoids; 0 / Glycerides; 0 / Polyunsaturated Alkamides; 0 / URB602; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 53847-30-6 / 2-arachidonylglycerol; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
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27. Horny HP, Sotlar K, Stellmacher F, Krokowski M, Agis H, Schwartz LB, Valent P: The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers. J Clin Pathol; 2006 Mar;59(3):298-302
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  • AIMS: Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis.
  • METHODS: A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows).
  • RESULTS: In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML).
  • The basophil specific antigen 2D7 was only detected in CD34/Kit negative TROCI-BM cells in two patients with CMLba.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Basophils / chemistry. Biomarkers / analysis. Cell Lineage. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Leukemia, Mast-Cell / diagnosis. Male. Mast Cells / chemistry. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / genetics. Receptors, Interleukin-2 / analysis. Retrospective Studies. Tryptases

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  • (PMID = 16505282.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.59 / Tryptases
  • [Other-IDs] NLM/ PMC1860329
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28. Gill RM, Etzell JE: Basophilic leukemia in recurrent chronic myelogenous leukemia blast phase. Am J Hematol; 2007 Aug;82(8):736-7
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  • [Title] Basophilic leukemia in recurrent chronic myelogenous leukemia blast phase.
  • [MeSH-major] Blast Crisis / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology

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  • (PMID = 17492647.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Vandevoorde S, Jonsson KO, Labar G, Persson E, Lambert DM, Fowler CJ: Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. Br J Pharmacol; 2007 Jan;150(2):186-91
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  • The lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis was also observed for intact RBL2H3 basophilic leukaemia cells.

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  • (PMID = 17143303.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Arachidonic Acids; 0 / Benzoxazines; 0 / Biphenyl Compounds; 0 / Endocannabinoids; 0 / Glycerides; 0 / Polyunsaturated Alkamides; 0 / Recombinant Proteins; 0 / URB 754; 0 / URB602; 94421-68-8 / anandamide; 9A2389K694 / 2-oleoylglycerol; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2042901
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30. Hochwallner H, Schulmeister U, Swoboda I, Balic N, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, van Tol EA, Valenta R, Spitzauer S: Microarray and allergenic activity assessment of milk allergens. Clin Exp Allergy; 2010 Dec;40(12):1809-18
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  • The allergenic activity of the individual allergens was tested using patients' sera for loading rat basophil leukaemia cells (RBL) expressing the α-chain of the human receptor FcεRI.

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20860558.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / Milk Proteins; 0 / Receptors, Fc; 37341-29-0 / Immunoglobulin E
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31. Nowak-Lovato KL, Rector KD: Targeted surface-enhanced Raman scattering nanosensors for whole-cell pH imagery. Appl Spectrosc; 2009 Apr;63(4):387-95
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  • The sensing component of the nanosensor is calibrated with in vivo measurements of rat basophil leukemia (RBL-2H3) cells in standard buffer solutions using the ionophore nigericin, which serves to equilibrate the external [H(+)] concentration with that of the cell compartments.

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  • (PMID = 19366503.001).
  • [ISSN] 0003-7028
  • [Journal-full-title] Applied spectroscopy
  • [ISO-abbreviation] Appl Spectrosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MS4A2 protein, human; 0 / Pyridines; 0 / Receptors, IgE; 1094-76-4 / epsilon-dinitrophenyllysine; 3M4G523W1G / Silver; 4556-23-4 / 4-thiopyridine; 7440-57-5 / Gold; K3Z4F929H6 / Lysine
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32. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC: Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology; 2006 Jul;131(1):47-58
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  • Finally, delivery of antigen-IgE complexes across the epithelial barrier could induce the degranulation of rat basophil leukemia cells transfected with the human high-affinity IgE receptor.

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  • (PMID = 16831589.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-45343; United States / NIDDK NIH HHS / DK / DK-071576
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / RNA, Messenger; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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33. Thors L, Alajakku K, Fowler CJ: The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. Br J Pharmacol; 2007 Apr;150(7):951-60
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  • KEY RESULTS: The FAAH inhibitor URB597 inhibited the uptake of anandamide into C6 glioma, RBL2H3 basophilic leukaemia cells and P19 embryonic carcinoma cells at incubation time 4 min.

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  • (PMID = 17325653.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 1400-61-9 / Nystatin; 4G7DS2Q64Y / Progesterone; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2013877
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34. Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, Edwards BS: Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry A; 2009 Mar;75(3):253-63
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  • U937 cells expressing FPR and rat basophil leukemia (RBL) cells expressing FPRL1 were tested together in a "duplex" format.

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  • [Copyright] 2008 International Society for Advancement of Cytometry.
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  • (PMID = 18785269.001).
  • [ISSN] 1552-4930
  • [Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology
  • [ISO-abbreviation] Cytometry A
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / U54 MH074425; United States / NIMH NIH HHS / MH / R03 MH076381-01; United States / NIMH NIH HHS / MH / MH076381-01; United States / NIMH NIH HHS / MH / R03 MH076381; United States / NIMH NIH HHS / MH / U54 MH074425-01
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemotactic Factors; 0 / FPR2 protein, human; 0 / Fluorescent Dyes; 0 / Ligands; 0 / Molecular Probes; 0 / Receptors, Formyl Peptide; 0 / Receptors, Lipoxin
  • [Other-IDs] NLM/ NIHMS76367; NLM/ PMC2645486
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35. Wanich N, Bencharitiwong R, Tsai T, Nowak-Wegrzyn A: In vitro assessment of the allergenicity of a novel influenza vaccine produced in dog kidney cells in individuals with dog allergy. Ann Allergy Asthma Immunol; 2010 May;104(5):426-33
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  • METHODS: Rat basophil leukemia (RBL) cells transfected with human IgE receptor-1 were sensitized with sera from dog-allergic adults with positive skin prick test reactions to dog extract and detectable dog dander IgE and were stimulated with serial dilutions of vaccine and dog dander extract.

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  • (PMID = 20486334.001).
  • [ISSN] 1081-1206
  • [Journal-full-title] Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • [ISO-abbreviation] Ann. Allergy Asthma Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 059318.R
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Anti-Idiotypic; 0 / Influenza Vaccines; 0 / Vaccines, Inactivated; 0 / anti-IgE antibodies
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36. Avril T, Freeman SD, Attrill H, Clarke RG, Crocker PR: Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem; 2005 May 20;280(20):19843-51
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  • To investigate the role of these motifs in Siglec-5-dependent signaling, we used transfected rat basophil leukemia cells as a model system.

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  • (PMID = 15769739.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Intracellular Signaling Peptides and Proteins; 0 / Lectins; 0 / Recombinant Fusion Proteins; 0 / SIGLEC5 protein, human; 42HK56048U / Tyrosine; 9007-49-2 / DNA; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / PTPN6 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Ptpn11 protein, rat; EC 3.1.3.48 / Ptpn6 protein, rat
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37. Bandbon Balenga NA, Thalhamer J, Weiss R: Bicistronic expression plasmid encoding allergen and anti-IgE single chain variable fragment antibody as a novel DNA vaccine for allergy therapy and prevention. Med Hypotheses; 2006;67(1):71-4
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  • Also, rat basophil leukemia cell assay (using RBL-2H3 cells) can show the amount of functional IgE in sera as basophil mediator release is regarded as an indicator of the allergic hypersensitive reactions.

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  • (PMID = 16513289.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Immunoglobulin Variable Region; 0 / Vaccines, DNA; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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38. Walgraffe D, Mattéotti C, El Bakkoury M, Garcia L, Marchand C, Bullens D, Vandenbranden M, Jacquet A: A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines. J Allergy Clin Immunol; 2009 May;123(5):1150-6
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  • Both ProDer p 1 forms were able to retain the Der p 1-specific T-cell reactivity but direct ELISA, competitive inhibition, and rat basophil leukemia assays clearly showed that ProDer p 1 coli displays a very weak IgE reactivity.

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  • (PMID = 19152967.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Dermatophagoides; 0 / Arthropod Proteins; 0 / Bronchoconstrictor Agents; 0 / Interleukin-5; 0 / Recombinant Proteins; 0 / Vaccines; 0W5ETF9M2K / Methacholine Chloride; 37341-29-0 / Immunoglobulin E; 82115-62-6 / Interferon-gamma; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.- / Dermatophagoides pteronyssinus antigen p 1
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39. Lenman A, Fowler CJ: Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. Br J Pharmacol; 2007 Aug;151(8):1343-51
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  • EXPERIMENTAL APPROACH: Fatty acid amide hydrolase activity was measured in rat brain homogenates, C6 glioma and RBL2H3 basophilic leukaemia cells.
  • [MeSH-minor] Animals. Brain / enzymology. Brain Neoplasms / enzymology. Brain Neoplasms / pathology. Cell Line, Tumor. Dose-Response Relationship, Drug. Drug Design. Glioma / enzymology. Glioma / pathology. Hydrogen-Ion Concentration. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / pathology. Ligands. Male. Monoacylglycerol Lipases / drug effects. Monoacylglycerol Lipases / metabolism. Rats. Rats, Sprague-Dawley. Receptor, Cannabinoid, CB1 / drug effects. Receptor, Cannabinoid, CB1 / metabolism. Receptor, Cannabinoid, CB2 / drug effects. Receptor, Cannabinoid, CB2 / metabolism. Thiazolidinediones / administration & dosage. Thiazolidinediones / pharmacology

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  • (PMID = 17592505.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Cannabinoid Receptor Modulators; 0 / Endocannabinoids; 0 / Ligands; 0 / PPAR gamma; 0 / Receptor, Cannabinoid, CB1; 0 / Receptor, Cannabinoid, CB2; 0 / Thiazolidinediones; 74772-77-3 / ciglitazone; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2189817
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40. Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL: Targeting of histamine producing cells by EGCG: a green dart against inflammation? J Physiol Biochem; 2010 Sep;66(3):265-70
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  • Their deregulation is related with many highly prevalent, as well as emergent and rare diseases, mainly those described as inflammation-dependent pathologies, including mastocytosis, basophilic leukemia, gastric ulcer, Crohn disease, and other inflammatory bowel diseases.

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  • (PMID = 20652470.001).
  • [ISSN] 1138-7548
  • [Journal-full-title] Journal of physiology and biochemistry
  • [ISO-abbreviation] J. Physiol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Tea; 820484N8I3 / Histamine; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate
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41. Gieras A, Focke-Tejkl M, Ball T, Verdino P, Hartl A, Thalhamer J, Valenta R: Molecular determinants of allergen-induced effector cell degranulation. J Allergy Clin Immunol; 2007 Feb;119(2):384-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A hybridoma cell line producing a monoclonal IgE antibody against a Phl p 1-derived peptide, P1, was established by means of immunization of mice and used to sensitize rat basophil leukemia cells, which were exposed to P1 monomer, P1 dimer, and P1 polymer.
  • [MeSH-minor] Amino Acid Sequence. Animals. Antibodies, Monoclonal / immunology. Cell Line, Tumor. Epitopes. Leukemia, Basophilic, Acute / immunology. Molecular Sequence Data. Rats

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  • (PMID = 17291855.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Epitopes; 0 / Plant Proteins; 160227-82-7 / PHLPI protein, Phleum pratense; 37341-29-0 / Immunoglobulin E
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42. Lahortiga I, Akin C, Cools J, Wilson TM, Mentens N, Arthur DC, Maric I, Noel P, Kocabas C, Marynen P, Lessin LS, Wlodarska I, Robyn J, Metcalfe DD: Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion. Haematologica; 2008 Jan;93(1):49-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion.
  • [MeSH-major] Gene Expression Regulation, Leukemic. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Mastocytosis, Systemic / drug therapy. Mastocytosis, Systemic / genetics. Oncogene Proteins, Fusion / genetics. Piperazines / pharmacology. Pyrimidines / pharmacology. Receptor, Platelet-Derived Growth Factor beta / chemistry

  • Genetic Alliance. consumer health - Mast cell disease.
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  • (PMID = 18166785.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Benzamides; 0 / Oncogene Proteins, Fusion; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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43. Tang G, Woods LJ, Wang SA, Brettler D, Andersen M, Miron PM, Pechet L, Woda BA, Hao S: Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm. Hum Pathol; 2009 Aug;40(8):1194-9
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  • [Title] Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm.
  • Chronic basophilic leukemia is a rare and poorly characterized entity.
  • [MeSH-major] Basophils / pathology. Leukemia, Myeloid, Chronic-Phase / pathology

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  • (PMID = 19427022.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ETS translocation variant 6 protein; 0 / Proto-Oncogene Proteins c-ets; 0 / Repressor Proteins
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44. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats






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