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1. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Line, Tumor. Humans. Intestines / microbiology. Lactobacillus / physiology. Rats. Signal Transduction

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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2. Kato N, Nakanishi M, Hirashima N: Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J Immunol; 2006 Jul 1;177(1):147-54
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  • [Title] Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
  • Cross-linking of high-affinity IgE receptors by multivalent Ag on mast cells (rat basophilic leukemia (RBL)-2H3) induces the phosphorylation of ITAM motifs of an IgE receptor by Src family tyrosine kinase, Lyn.
  • We obtained flotillin-1 knockdown (KD)(2) rat basophilic leukemia (RBL)-2H3 cells, which express a low level of flotillin-1.
  • [MeSH-minor] Animals. Calcium / metabolism. Calcium Signaling / physiology. Cell Degranulation / physiology. Cell Line, Tumor. Enzyme Activation / physiology. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / enzymology. Membrane Microdomains / immunology. Membrane Microdomains / metabolism. Phosphorylation. Rats. Transfection. Tyrosine / metabolism. src-Family Kinases / metabolism

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  • (PMID = 16785509.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE; 0 / flotillins; 42HK56048U / Tyrosine; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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3. Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M: Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells. Biol Pharm Bull; 2007 Mar;30(3):443-6
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  • [Title] Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.
  • To trigger degranulation, rat basophilic leukemia (RBL)-2H3 cells were passively sensitized using an antiserum collected from ovalbumin (OA) immunized-Brown Norway rats, and the cells were stimulated by treatment with OA.
  • [MeSH-major] Cell Degranulation. Heme Oxygenase-1 / metabolism. Leukemia, Basophilic, Acute / metabolism

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  • (PMID = 17329835.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 2',7'-dichlorodihydrofluorescein diacetate; 0 / Azo Compounds; 0 / Enzyme Inhibitors; 0 / Fluoresceins; 0 / Free Radical Scavengers; 0 / Metalloporphyrins; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0KAE1U0G7Q / tin mesoporphyrin; 6226-79-5 / ponceau S; 9006-59-1 / Ovalbumin; EC 1.14.99.3 / Heme Oxygenase-1; WYQ7N0BPYC / Acetylcysteine
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4. Lim H, Son KH, Chang HW, Bae K, Kang SS, Kim HP: Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull; 2008 Nov;31(11):2063-7
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  • In order to identify the active anti-inflammatory ingredient(s) in Cirsium chanroenicum (Compositae), its methanol extract and several solvent fractions were prepared; the methanol extract and the ethylacetate fraction inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE2) and 5-lipoxygenase (5-LOX)-mediated leukotriene (LT) production in lipopolysaccharide-treated RAW 264.7 cells and A23187-treated rat basophilic leukemia (RBL-1) cells, respectively.

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  • (PMID = 18981574.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Chromones; 0 / Leukotrienes; 0 / NF-kappa B; 0 / pectolinarigenin; 28978-02-1 / pectolinarin; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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5. Ljubić N, Lang N, Skelin IK, Lasan R, Dominis M, Perković L, Zupanić-Krmek D, Grgurević-Batinica A: Klinefelter syndrome and acute basophilic leukaemia--case report. Coll Antropol; 2010 Jun;34(2):657-60
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  • [Title] Klinefelter syndrome and acute basophilic leukaemia--case report.
  • Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia.
  • We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells.
  • Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias.
  • Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules.
  • There is no consistent chromosomal abnormality identified in this leukaemia.
  • This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome.
  • In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
  • [MeSH-major] Klinefelter Syndrome / complications. Leukemia, Basophilic, Acute / complications

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  • (PMID = 20698148.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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6. Linhart B, Bigenzahn S, Hartl A, Lupinek C, Thalhamer J, Valenta R, Wekerle T: Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol; 2007 Mar 15;178(6):3924-31
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  • Immediate-type reactions as analyzed by a rat basophil leukemia cell mediator release assay were only suppressed by early treatment but not by a costimulation blockade after sensitization.

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  • (PMID = 17339493.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / FWF/ F 2310
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Immunoconjugates; 0 / Immunosuppressive Agents; 0 / PHLPII protein, Phleum pratense; 0 / Phl p V protein, Phleum pratense; 0 / Plant Proteins; 147205-72-9 / CD40 Ligand; 37341-29-0 / Immunoglobulin E; 7D0YB67S97 / Abatacept
  • [Other-IDs] NLM/ PMC2993922; NLM/ UKMS32950
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7. Heneberg P, Lebduska P, Dráberová L, Korb J, Dráber P: Topography of plasma membrane microdomains and its consequences for mast cell signaling. Eur J Immunol; 2006 Oct;36(10):2795-806
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  • In this study we used rat basophilic leukemia cells and their transfectants expressing both endogenous Thy-1.1 and exogenous Thy-1.2 genes and analyzed topography of the Thy-1 isoforms and Thy-1-induced signaling events.

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  • (PMID = 17013982.001).
  • [ISSN] 0014-2980
  • [Journal-full-title] European journal of immunology
  • [ISO-abbreviation] Eur. J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, Thy-1; 0 / Lat protein, mouse; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / Receptors, IgE
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8. Smrz D, Lebduska P, Dráberová L, Korb J, Dráber P: Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis. J Biol Chem; 2008 Apr 18;283(16):10904-18
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  • Using rat basophilic leukemia cells as a model, we show that nonapoptotic PS externalization induced through the high affinity IgE receptor (FcepsilonRI) or the glycosylphosphatidylinositol-anchored protein Thy-1 does not correlate with enhanced tyrosine phosphorylation of PLSCR1.

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  • (PMID = 18281686.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Detergents; 0 / Enzyme Inhibitors; 0 / Ionophores; 0 / Phosphatidylserines; 0 / Phospholipid Transfer Proteins; 0 / pervanadate; 37H9VM9WZL / Calcimycin; 3WHH0066W5 / Vanadates; 42HK56048U / Tyrosine
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9. Barth EE, Hallworth R, Nichols MG: A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells. Photochem Photobiol; 2005 May-Jun;81(3):556-62
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  • [Title] A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells.
  • Photodamage was induced in rat basophilic leukemia cells by either 254-nm UVC light exposure or rose bengal photosensitization.
  • [MeSH-major] Cell Division / radiation effects. Leukemia / pathology. Rose Bengal / toxicity. Ultraviolet Rays / adverse effects

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  • (PMID = 15773792.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Photosensitizing Agents; 1N3CZ14C5O / Rhodamine 123; 1ZPG1ELY14 / Rose Bengal; 36015-30-2 / Propidium; EC 3.1.- / Esterases; G34N38R2N1 / Bromodeoxyuridine; V0YM2B16TS / fluorexon
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10. Yamaki K, Yoshino S: Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. Environ Toxicol Pharmacol; 2010 Mar;29(2):183-9

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  • [Title] Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.
  • The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 21787600.001).
  • [ISSN] 1872-7077
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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11. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Leukemia, Basophilic, Acute / metabolism. Liver Neoplasms / metabolism. Microscopy, Confocal. NADP / metabolism

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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12. Liao BC, Hou RC, Wang JS, Jeng KC: Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells. J Biomed Sci; 2006 Sep;13(5):613-9
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  • [Title] Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells.
  • In this study, SP and dinitrophenyl-bovine serum albumin (DNP-BSA) were used to activate rat basophilic leukemia (RBL)-2H3 cells.

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  • (PMID = 16847722.001).
  • [ISSN] 1021-7770
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Ginsenosides; 0 / Inflammation Mediators; 0 / Serum Albumin, Bovine; 33507-63-0 / Substance P; 88140-34-5 / ginsenoside Rb1, malonyl
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13. Chen BH, Wu PY, Chen KM, Fu TF, Wang HM, Chen CY: Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod; 2009 May 22;72(5):950-3
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  • In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically.

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  • (PMID = 19271742.001).
  • [ISSN] 1520-6025
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Phenols
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14. Lichtman MA, Segel GB: Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review. Blood Cells Mol Dis; 2005 Nov-Dec;35(3):370-83
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  • [Title] Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.
  • The potential of the transformed (leukemic) multipotential hematopoietic cell to differentiate and mature along any myeloid lineage forms the basis for the phenotypic classification of acute and chronic myelogenous leukemia.
  • Although most cases of leukemia can be classified phenotypically by the dominant lineage expressed, the genotype within each phenotype is heterogeneous.
  • The least common AML phenotypes are a reflection of the least common blood or marrow cell lineages: acute basophilic, acute mast cell, acute eosinophilic, and acute myeloid dendritic cell leukemia.
  • [MeSH-major] Basophils / pathology. Dendritic Cells / pathology. Eosinophils / pathology. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Acute / pathology. Mast Cells / pathology. Myeloid Cells / pathology


15. Kim Y, Eom S, Kim K, Lee YS, Choe J, Hahn JH, Lee H, Kim YM, Ha KS, Ro JY, Jeoung D: Transglutaminase II interacts with rac1, regulates production of reactive oxygen species, expression of snail, secretion of Th2 cytokines and mediates in vitro and in vivo allergic inflammation. Mol Immunol; 2010 Feb;47(5):1010-22
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  • Antigen stimulation induced expression and activity of TGase II by activation of NF-kappaB in rat basophilic leukemia (RBL2H3) cells.

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  • [Copyright] (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20004474.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Cadherins; 0 / Carcinogens; 0 / Cytokines; 0 / NF-kappa B; 0 / Neuropeptides; 0 / Rac1 protein, mouse; 0 / Reactive Oxygen Species; EC 2.3.2.- / transglutaminase 2; EC 2.3.2.13 / Transglutaminases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.5.1.98 / Histone Deacetylases; EC 3.5.1.98 / histone deacetylase 3; EC 3.6.1.- / GTP-Binding Proteins; EC 3.6.1.- / Rac1 protein, rat; EC 3.6.5.2 / rac GTP-Binding Proteins; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase; K7Q1JQR04M / Dinoprostone; NI40JAQ945 / Tetradecanoylphorbol Acetate
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16. Blanc F, Adel-Patient K, Drumare MF, Paty E, Wal JM, Bernard H: Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy; 2009 Aug;39(8):1277-85

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  • OBJECTIVES: We optimized an in vitro functional assay to assess the capacity of peanut allergens to degranulate humanized rat basophilic leukaemia cells, RBL SX-38 cells, after sensitization by serum IgE from peanut-allergic patients.
  • [MeSH-major] 2S Albumins, Plant / immunology. Allergens / immunology. Antigens, Plant / immunology. Basophil Degranulation Test. Glycoproteins / immunology. Peanut Hypersensitivity / immunology

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  • (PMID = 19538351.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / Ara h 6 allergen, Arachis hypogaea; 0 / Glycoproteins; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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17. Kato N, Motohashi S, Okada T, Ozawa T, Mashima K: PICOT, protein kinase C theta-interacting protein, is a novel regulator of FcepsilonRI-mediated mast cell activation. Cell Immunol; 2008 Jan;251(1):62-7
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  • Using PICOT overexpressing rat basophilic leukemia cells (RBL-2H3), we evaluated the effect of PICOT overexpression on the FcepsilonRI-mediated signaling.

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  • (PMID = 18479680.001).
  • [ISSN] 1090-2163
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Carrier Proteins; 0 / Cytokines; 0 / NF-kappa B; 0 / NFATC Transcription Factors; 0 / Receptors, IgE; 0 / Txnl2 protein, mouse; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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18. Suzuki R, Furuno T, Okamoto K, Teshima R, Nakanishi M: ATP plays a role in neurite stimulation with activated mast cells. J Neuroimmunol; 2007 Dec;192(1-2):49-56
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  • Addition of antigen to the cocultures of superior cervical ganglia (SCG) and rat basophilic leukemia cells (RBLs) elicited Ca(2+) response in RBLs and after a lag period induced Ca(2+) signal in SCG neurites.

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  • (PMID = 17928071.001).
  • [ISSN] 0165-5728
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dinitrophenols; 0 / Receptors, Cell Surface; 0 / Serum Albumin, Bovine; 0 / dinitrophenyl-bovine serum albumin; 333DO1RDJY / Serotonin; 820484N8I3 / Histamine; 8L70Q75FXE / Adenosine Triphosphate; SY7Q814VUP / Calcium
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19. Sagi-Eisenberg R: The mast cell: where endocytosis and regulated exocytosis meet. Immunol Rev; 2007 Jun;217:292-303
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  • Studying the function of Syt II-knocked down rat basophilic leukemia cells has shown a dual function of this homologue.

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  • (PMID = 17498067.001).
  • [ISSN] 0105-2896
  • [Journal-full-title] Immunological reviews
  • [ISO-abbreviation] Immunol. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Neuronal Calcium-Sensor Proteins; 0 / Neuropeptides; 0 / Receptors, IgE; 0 / frequenin calcium sensor proteins; 134193-27-4 / Synaptotagmins; EC 2.7.11.13 / Protein Kinase C-alpha; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Number-of-references] 138
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20. Giudice ED, Rinaldi L, Passarotto M, Facchinetti F, D'Arrigo A, Guiotto A, Carbonare MD, Battistin L, Leon A: Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells. J Leukoc Biol; 2007 Jun;81(6):1512-22
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  • By using the rat basophilic leukemia mast cell line (RBL-2H3), we demonstrate that CBD (3-10 muM) augments beta-hexosaminidase release, a marker of cell activation, from antigen-stimulated and unstimulated cells via a mechanism, which is not mediated by G(i)/G(o) protein-coupled receptors but rather is associated with a robust rise in intracellular calcium ([Ca(2+)](i)) levels sensitive to clotrimazole and nitrendipine (10-30 muM).

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  • (PMID = 17339608.001).
  • [ISSN] 0741-5400
  • [Journal-full-title] Journal of leukocyte biology
  • [ISO-abbreviation] J. Leukoc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzoxazines; 0 / Cannabinoids; 0 / Cyclohexanols; 0 / Morpholines; 0 / Naphthalenes; 0 / TRPV Cation Channels; 0 / TRPV1 receptor; 134959-51-6 / Win 55212-2; 19GBJ60SN5 / Cannabidiol; 7J8897W37S / Dronabinol; 83003-12-7 / 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; S07O44R1ZM / Capsaicin; SY7Q814VUP / Calcium
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21. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC: Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology; 2006 Jul;131(1):47-58
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  • Finally, delivery of antigen-IgE complexes across the epithelial barrier could induce the degranulation of rat basophil leukemia cells transfected with the human high-affinity IgE receptor.

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  • (PMID = 16831589.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-45343; United States / NIDDK NIH HHS / DK / DK-071576
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / RNA, Messenger; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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22. Toda M, Nakamura T, Ohbayashi M, Ikeda Y, Dawson M, Richardson RM, Alban A, Leed B, Miyazaki D, Ono SJ: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FcepsilonRI- and/or CCR1-engaged mast cells using protein chip technology. Novartis Found Symp; 2005;271:131-40; discussion 140-51
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  • We have found that costimulation with IgE/antigen and CC chemokine ligand 3 (CCL3) enhances degranulation but inhibits chemotaxis of rat basophilic leukaemia (RBL)-2H3 cells expressing human CCR1 (RBL-CCR1 cells).

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  • (PMID = 16605132.001).
  • [ISSN] 1528-2511
  • [Journal-full-title] Novartis Foundation symposium
  • [ISO-abbreviation] Novartis Found. Symp.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / CCR1 protein, human; 0 / CCR3 protein, human; 0 / Ccr1 protein, mouse; 0 / Ccr1 protein, rat; 0 / Ccr3 protein, mouse; 0 / Ccr3 protein, rat; 0 / Chemokines, CC; 0 / Receptors, CCR1; 0 / Receptors, CCR3; 0 / Receptors, Chemokine; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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23. Liu-Bryan R, Pay S, Schraufstatter IU, Rose DM: The CXCR1 tail mediates beta1 integrin-dependent cell migration via MAP kinase signaling. Biochem Biophys Res Commun; 2005 Jun 24;332(1):117-25
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  • We assessed individual contributions of signaling by IL-8 receptors by transfection of CXCR1 and CXCR2 into rat basophilic leukemia (RBL) cells and human monocytic THP-1 cells.

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  • (PMID = 15896307.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL55657; United States / NIAMS NIH HHS / AR / P30AR47360; United States / NIAMS NIH HHS / AR / R03AR49416
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Interleukin-8; 0 / Receptors, Interleukin-8A; 0 / Receptors, Interleukin-8B; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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24. Pidala J, Pinilla-Ibarz J, Cualing HD: A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet; 2008 Apr 1;182(1):46-9
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  • [Title] A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies.
  • A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • [MeSH-major] Chromosomes, Human, Pair 7. Chromosomes, Human, Pair 8. Leukemia, Basophilic, Acute / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Translocation, Genetic

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  • (PMID = 18328951.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Kobayashi S, Tanabe S: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. Int J Mol Med; 2006 Mar;17(3):511-5
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  • [Title] Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
  • To examine this anti-allergic mechanism in detail, we next used rat basophlilic leukemia RBL-2H3 cells.
  • [MeSH-major] Anti-Allergic Agents / therapeutic use. Basophils / drug effects. Citrus. Leukemia, Basophilic, Acute / immunology. Phytotherapy. Pollen / immunology. Rhinitis, Allergic, Seasonal / drug therapy

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  • (PMID = 16465400.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Flavonoids; 0 / Plant Preparations; 37341-29-0 / Immunoglobulin E; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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26. Lippert U, Ferrari DM, Jahn R: Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells. FEBS Lett; 2007 Jul 24;581(18):3479-84
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  • [Title] Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells.
  • We used permeabilized rat basophilic leukaemia cells as model to identify R-SNAREs (soluble NSF (N-ethylmaleimide-sensitive fusion protein)) mediating exocytosis of hexosaminidase from mast cells.
  • [MeSH-major] Basophils / metabolism. Exocytosis. Hexosaminidases / metabolism. Hexosaminidases / secretion. Leukemia / metabolism. R-SNARE Proteins / metabolism

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  • (PMID = 17618625.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / R-SNARE Proteins; 0 / Streptolysins; 0 / Vamp8 protein, rat; 0 / Vesicle-Associated Membrane Protein 2; 0 / Vesicle-Associated Membrane Protein 3; 0 / streptolysin O; EC 3.2.1.- / Hexosaminidases; SY7Q814VUP / Calcium
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27. Rashid A, Iodice MW, Carroll KM, Housden JE, Hunter M, Sabban S, Artymiuk PJ, Helm BA: Assessing the role of Asp 194 in the transmembrane domains of the α-chain of the high-affinity receptor complex for immunoglobulin E in signal transduction. Mol Immunol; 2010 Nov-Dec;48(1-3):128-36
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  • Rat basophilic leukemia cells (RBL-2H3) transfected with the human IgE binding subunit (FcɛRIα) incorporating polar substitutions like asparagine (D194N) or threonine (D194T) resulted in the formation of a functional rat/human chimeric receptor complex.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • [CommentIn] Mol Immunol. 2011 Apr;48(8):979-80 [21216468.001]
  • (PMID = 20947168.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, IgE; 30KYC7MIAI / Aspartic Acid
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28. Cho YS, Kim CH, Surh JH, Kang NS, Yoo SE, Cheon HG: Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity. Pharmacology; 2010;86(2):65-72
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  • The leukotriene B(4) (LTB(4)) level was assayed in rat basophilic leukemia (RBL-1) cell line.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20639685.001).
  • [ISSN] 1423-0313
  • [Journal-full-title] Pharmacology
  • [ISO-abbreviation] Pharmacology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / 4-(4-(4-fluorophenyl)thiazol-2-ylamino)-2,6-dimethylphenol; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Isoenzymes; 0 / Lipoxygenase Inhibitors; 0 / Recombinant Proteins; 0 / Thiazoles; 0 / Xylenes; 1HGW4DR56D / Leukotriene B4; 27YG812J1I / Arachidonic Acid; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; GE3IBT7BMN / Dinitrochlorobenzene
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29. Qian W, Zhang X, Li B, Zhang D, Tong Q, Chen L, Zheng L, Kou G, Wang H, Hou S, Guo Y: Development and characterization of a novel anti-IgE monoclonal antibody. Biochem Biophys Res Commun; 2010 May 14;395(4):547-52
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  • Importantly, 7A5 was able to inhibit IgE-induced histamine release of basophilic leukemia cells.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20394728.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Peptide Library; 0 / Peptides; 0 / Receptors, IgE; 0 / anti-IgE antibodies; 37341-29-0 / Immunoglobulin E
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30. Sakai S, Sugawara T, Kishi T, Yanagimoto K, Hirata T: Effect of glucosamine and related compounds on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice. Life Sci; 2010 Feb 27;86(9-10):337-43
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  • MAIN METHODS: Dinitrophenyl (DNP)-IgE-sensitized rat basophilic leukemia RBL-2H3 cells were treated with glucosamine-HCl (GlcN-HCl), N-acetylglucosamine (GlcNAc), chitin oligomer or chitosan oligomer.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20093129.001).
  • [ISSN] 1879-0631
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] D241E059U6 / Dinitrofluorobenzene; N08U5BOQ1K / Glucosamine
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31. Hunter MJ, Iodice MW, Pathak AK, Street MA, Helm BA: Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. Mol Immunol; 2009 Mar;46(6):1260-5
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  • A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell line transfected with the alpha-chain subunit of the canine high-affinity IgE receptor using flow cytometry show that canine IgE recognizes the alpha-chain of its cognate receptor on both cell lines.

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  • (PMID = 19135724.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBSQ/Q/2005/06706
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; 37H9VM9WZL / Calcimycin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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32. Urrea Moreno R, Gil J, Rodriguez-Sainz C, Cela E, LaFay V, Oloizia B, Herr AB, Sumegi J, Jordan MB, Risma KA: Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood; 2009 Jan 8;113(2):338-46
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  • In a family affected by hemophagocytic lymphohistiocytosis, a severe inflammatory disorder caused by perforin deficiency, we identified 2 amino acid substitutions in the perforin C2 domain: T435M, a previously identified mutant with disputed pathogenicity, and Y438C, a novel substitution.
  • The capacity for cytotoxic function was tested after expression of the variant perforins in rat basophilic leukemia cells and murine cytotoxic T lymphocytes.

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  • (PMID = 18927437.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091769; United States / PHS HHS / / K12 CHILD HEALTH RESEARCH CAREER DEVELOPMENT AWARD; United States / NHLBI NIH HHS / HL / R01-HL091769
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Lipids; 126465-35-8 / Perforin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2615650
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33. Ozawa T, Nakata K, Mizuno K, Yakura H: Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells. Int Immunol; 2007 Sep;19(9):1049-61
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  • [Title] Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.
  • When phosphatase-inactive SHP-1 was over-expressed in rat basophilic leukemia (RBL)-2H3 cells, tyrosine phosphorylation of a 68-kDa protein was enhanced before and after FcepsilonRI aggregation.
  • [MeSH-major] Leukemia, Basophilic, Acute / immunology. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / immunology

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  • (PMID = 17675340.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Receptors, IgE; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Ptpn6 protein, rat
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34. Mitsutake S, Igarashi Y: Transbilayer movement of ceramide in the plasma membrane of live cells. Biochem Biophys Res Commun; 2007 Aug 3;359(3):622-7
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  • To produce Cer on the extracellular leaflet of the PM, bacterial sphingomyelinase (SMase) was added to rat basophilic leukemia cells.

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  • (PMID = 17553461.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ceramides; 0 / Membrane Transport Proteins; 0 / Phosphates; 97C5T2UQ7J / Cholesterol; EC 3.1.4.12 / Sphingomyelin Phosphodiesterase
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35. Wu J, Ji C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP: FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol; 2007 Mar 15;178(6):3973-82
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  • The two different alleles demonstrate significantly different FcalphaRI-mediated intracellular calcium mobilization and degranulation in rat basophilic leukemia cells and cytokine production (IL-6 and TNF-alpha) in murine macrophage P388D1 cells.

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  • (PMID = 17339498.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / P30 AR 48311; United States / NIAMS NIH HHS / AR / R01 AR 33062; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCRR NIH HHS / RR / M01 RR 00032; United States / NIAMS NIH HHS / AR / R01 AR033062; United States / NIAID NIH HHS / AI / N01 AI 40068; United States / NIAMS NIH HHS / AR / P01 AR 49084
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / IL6 protein, human; 0 / Immunoglobulin A; 0 / Interleukin-6; 0 / Receptors, Fc; 0 / Tumor Necrosis Factor-alpha
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36. Thors L, Alajakku K, Fowler CJ: The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. Br J Pharmacol; 2007 Apr;150(7):951-60
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  • KEY RESULTS: The FAAH inhibitor URB597 inhibited the uptake of anandamide into C6 glioma, RBL2H3 basophilic leukaemia cells and P19 embryonic carcinoma cells at incubation time 4 min.

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  • (PMID = 17325653.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 1400-61-9 / Nystatin; 4G7DS2Q64Y / Progesterone; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2013877
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37. Marazuela EG, Rodríguez R, Barber D, Villalba M, Batanero E: Hypoallergenic mutants of Ole e 1, the major olive pollen allergen, as candidates for allergy vaccines. Clin Exp Allergy; 2007 Feb;37(2):251-60
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  • Their allergenicity was also investigated in both a mouse model of allergic sensitization and in basophil activation assays.
  • Rat basophil leukaemia assays identified the deletion mutant 135Delta10 as the variant with the lowest beta-hexosaminidase-releasing capacity.

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  • (PMID = 17250698.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Ole e I protein, Olea europaea; 0 / Plant Proteins; 0 / Vaccines, Synthetic
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38. Yasui Y, Nakamura M, Onda T, Uehara T, Murata S, Matsui N, Fukuishi N, Akagi R, Suematsu M, Akagi M: Heme oxygenase-1 inhibits cytokine production by activated mast cells. Biochem Biophys Res Commun; 2007 Mar 9;354(2):485-90
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  • We examined whether rat HO-1 cDNA transfected rat basophilic leukemia (RBL)-2H3 cells have altered cytokine production in response to stimulation with anti-ovalbumin (OA) serum/OA compared to Mock transfected RBL-2H3 cells.

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  • (PMID = 17234154.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Transcription Factor AP-1; EC 1.14.99.3 / Heme Oxygenase-1
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39. Puri N, Roche PA: Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic; 2006 Nov;7(11):1482-94
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  • To investigate the role of lipid rafts in secretory granule exocytosis, we examined the raft association of SNARE proteins and SNARE complexes in rat basophilic leukemia (RBL) mast cells.

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  • (PMID = 16984405.001).
  • [ISSN] 1398-9219
  • [Journal-full-title] Traffic (Copenhagen, Denmark)
  • [ISO-abbreviation] Traffic
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dinitrophenols; 0 / Qa-SNARE Proteins; 0 / Receptors, IgE; 0 / SNARE Proteins; 0 / Serum Albumin, Bovine; 0 / Snap23 protein, rat; 0 / Snap25 protein, mouse; 0 / Synaptosomal-Associated Protein 25; 0 / Vesicle-Associated Membrane Protein 2; 0 / Vesicular Transport Proteins; 0 / dinitrophenyl-bovine serum albumin; 37341-29-0 / Immunoglobulin E; 9012-63-9 / Cholera Toxin
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40. Biedermann B, Gil D, Bowen DT, Crocker PR: Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res; 2007 Feb;31(2):211-20
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  • [Title] Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.
  • CD33 (Siglec-3) is expressed on most acute myeloid leukemia (AML) cells and is currently being exploited as a therapeutic target.
  • Using primary AML cells or transfected rat basophilic leukemia cells, Siglec-9 mediated rapid endocytosis of anti-Siglec-9 mAb.
  • [MeSH-major] Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Hematopoietic Stem Cells / immunology. Lectins / analysis. Leukemia, Myeloid / immunology

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  • (PMID = 16828866.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD33 protein, human; 0 / Lectins; 0 / SIGLEC5 protein, human; 0 / SIGLEC7 protein, human; 0 / SIGLEC9 protein, human; 0 / Sialic Acid Binding Ig-like Lectin 3; 0 / Sialic Acid Binding Immunoglobulin-like Lectins
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41. Haberman Y, Ziv I, Gorzalczany Y, Fukuda M, Sagi-Eisenberg R: Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment. J Cell Sci; 2005 Apr 15;118(Pt 8):1641-9

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  • However, in the rat basophilic leukemia (RBL-2H3) mast cell line, as well as in CHO cells, Syt IX is localized at the endocytic recycling compartment (ERC).

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  • (PMID = 15784685.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Enzyme Inhibitors; 0 / Phorbol Esters; 0 / Syt9 protein, rat; 134193-27-4 / Synaptotagmins; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C beta; EC 2.7.11.13 / Protein Kinase C-alpha
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42. Yanase Y, Hiragun T, Kaneko S, Gould HJ, Greaves MW, Hide M: Detection of refractive index changes in individual living cells by means of surface plasmon resonance imaging. Biosens Bioelectron; 2010 Oct 15;26(2):674-81

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  • The SPRI sensor could detect reactions of individual rat basophilic leukemia (RBL-2H3) cells, mouse keratinocyte (PAM212) cells, and human epidermal carcinoma (A431) cells in response to either specific or non-specific stimuli, such as antigen, phorbol ester or epidermal growth factor, with or without their inhibitors, resembling signals obtained by a conventional SPR sensor.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673712.001).
  • [ISSN] 1873-4235
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MRC/ G0501494
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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43. Ferreres F, Pereira DM, Gil-Izquierdo A, Valentão P, Botelho J, Mouga T, Andrade PB: HPLC-PAD-atmospheric pressure chemical ionization-MS metabolite profiling of cytotoxic carotenoids from the echinoderm Marthasterias glacialis (spiny sea-star). J Sep Sci; 2010 Aug;33(15):2250-7
The Lens. Cited by Patents in .

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  • The purified carotenoid fraction displayed a strong cell proliferation inhibition against rat basophilic leukemia RBL-2H3 (IC(25)=268 microg/mL) cancer cell line.

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  • (PMID = 20574958.001).
  • [ISSN] 1615-9314
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 36-88-4 / Carotenoids
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44. Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T: Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol; 2010 Jul;10(7):769-76
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  • We examined the effects of Lico A and related chalcones on degranulation in a rat basophilic leukemia cell line, RBL-2H3.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399908.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Chalcones; 42HK56048U / Tyrosine; 58749-22-7 / licochalcone A; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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45. Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H: Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Planta Med; 2010 Oct;76(14):1512-8
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  • Wight on the basophilic cell-mediated allergic reaction.
  • The effect of acteoside on β-hexosaminidase release and intracellular [Ca (2+)] I level from rat basophilic leukemia (RBL-2H3) cells was determined.
  • Also, ELISA was used to determine the level of histamine, tumor necrosis factor (TNF)- α, and interleukin (IL)-4 on human basophilic (KU812) cells.
  • The effect of acteoside on basophilic cell viability was determined using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay.
  • Our findings provide evidence that acteoside inhibits basophilic cell-derived immediate-type and delayed-type allergic reactions.
  • This is the first report describing antiallergic activity of acteoside extracted from CISTANCHE TUBULOSA on basophilic cells.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20354949.001).
  • [ISSN] 1439-0221
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Catechols; 0 / Glucosides; 0 / Glycosides; 0 / IL4 protein, human; 0 / Phenols; 0 / Tumor Necrosis Factor-alpha; 0 / cistanoside A; 207137-56-2 / Interleukin-4; 37H9VM9WZL / Calcimycin; 61276-17-3 / acteoside; 820484N8I3 / Histamine; 82854-37-3 / echinacoside; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; NI40JAQ945 / Tetradecanoylphorbol Acetate; SY7Q814VUP / Calcium
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46. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y: Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol; 2010 Sep;32(3):454-61
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  • To investigate the antiallergic effects of fermented grape marc from Negroamaro (N-FGM), we examined antigen (Ag)-induced degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Antigens / immunology. Basophil Degranulation Test. Fermentation. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein-Tyrosine Kinases / metabolism. Rats. Syk Kinase. Tumor Cells, Cultured

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  • (PMID = 20100066.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/ BB/D008123/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 37341-29-0 / Immunoglobulin E; 9IKM0I5T1E / Quercetin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Syk Kinase; EC 2.7.10.2 / Syk protein, rat
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47. Gadermaier G, Jahn-Schmid B, Vogel L, Egger M, Himly M, Briza P, Ebner C, Vieths S, Bohle B, Ferreira F: Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol; 2010 Mar;47(6):1292-8
The Lens. Cited by Patents in .

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  • Mediator release assays using rat basophil leukemia cells showed that these variants displayed a 1x10(5)-fold reduced allergenic potency as compared to wild-type protein.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20022115.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / FWF/ P 20011
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies; 0 / Antigens, Plant; 0 / Art v 1 protein, mugwort; 0 / Mutant Proteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; K848JZ4886 / Cysteine
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48. Cohen R, Torres A, Ma HT, Holowka D, Baird B: Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells. J Immunol; 2009 Nov 15;183(10):6478-88
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  • Using single cell stimulation by IgE-specific Ag and high-speed imaging of conventional or genetically encoded Ca(2+) sensors in rat basophilic leukemia and bone marrow-derived rat mast cells, we observe Ca(2+) waves that originate most frequently from the tips of extended cell protrusions, as well as Ca(2+) oscillations throughout the cell that usually follow the initiating Ca(2+) wave.
  • Initiating Ca(2+) waves are observed in most rat basophilic leukemia cells stimulated with soluble Ag and are sensitive to inhibitors of Ca(2+) release from endoplasmic reticulum stores and to extracellular Ca(2+), but they do not depend on store-operated Ca(2+) entry.

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  • (PMID = 19864608.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / R01 AI022449-23; United States / NIAID NIH HHS / AI / AI022449
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Estrenes; 0 / Phosphodiesterase Inhibitors; 0 / Pyrrolidinones; 0 / TRPC Cation Channels; 0 / TRPC3 cation channel; 0 / transient receptor potential cation channel, subfamily C, member 1; 112648-68-7 / 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 37341-29-0 / Immunoglobulin E; I9ZF7L6G2L / Nifedipine; NGZ37HRE42 / Sphingosine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS265600; NLM/ PMC3037335
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49. Schulmeister U, Hochwallner H, Swoboda I, Focke-Tejkl M, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Keller W, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, Valenta R, Spitzauer S: Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen. J Immunol; 2009 Jun 1;182(11):7019-29
The Lens. Cited by Patents in .

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  • The allergenic activity of ralphaS1-casein and the alphaS1-casein-derived peptides was determined using rat basophil leukemia cells transfected with human FcepsilonRI, which had been loaded with the patients' serum IgE.
  • Our results demonstrate that ralphaS1-casein as well as alphaS1-casein-derived peptides exhibit IgE reactivity, but mainly the intact ralphaS1-casein induced strong basophil degranulation.

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  • (PMID = 19454699.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / DNA, Complementary; 0 / Epitopes; 0 / Peptide Fragments; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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50. Lim H, Son KH, Bae KH, Hung TM, Kim YS, Kim HP: 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. Phytother Res; 2009 Oct;23(10):1489-92
Hazardous Substances Data Bank. NITRIC OXIDE .

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  • The compounds including schizandrins, schisandrols, gomisins, fargesin, eudesmin and lirioresinol B dimethyl ether, inhibited 5-LOX-catalysed leukotriene production from A23187-treated rat basophilic leukemia (RBL-1) cells at concentrations of 1-100 microm.

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  • [Copyright] (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19277963.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Cyclooctanes; 0 / Leukotrienes; 0 / Lignans; 0 / Lipoxygenase Inhibitors; 0 / Plant Extracts; 0 / schisandrol A; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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51. Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C: A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem; 2009 Mar 27;284(13):8421-6
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  • Expressing OASF in rat basophilic leukemia (RBL) mast cells demonstrated its enhanced plasma membrane targeting associated with 2.5-fold larger CRAC currents in comparison with the complete STIM1 C terminus.

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  • (PMID = 19189966.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ P18169/ P18280/ P21118
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / Orai1 protein, rat; 0 / STIM1 protein, human; 0 / Stim1 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2659200
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52. Torres AJ, Vasudevan L, Holowka D, Baird BA: Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays. Proc Natl Acad Sci U S A; 2008 Nov 11;105(45):17238-44
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  • Patterned surfaces that present specific ligands in spatially defined arrays are used to examine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.
  • Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the patterned regions occupied by the ligands and associates preferentially with exposed regions of the silicon substrate.

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  • (PMID = 19004813.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI018306; United States / NIAID NIH HHS / AI / AI18306
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Ligands; 0 / Paxillin; 0 / RNA, Small Interfering; 0 / Receptors, IgE; 0 / Talin; 125361-02-6 / Vinculin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2582307
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53. Jensen BM, Swindle EJ, Iwaki S, Gilfillan AM: Generation, isolation, and maintenance of rodent mast cells and mast cell lines. Curr Protoc Immunol; 2006 Sep;Chapter 3:Unit 3.23
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  • In addition to human mast cells, the major cell culture systems employed to investigate these responses are rat and mouse peritoneal mast cells, mouse bone-marrow-derived mast cells, the rat basophilic leukemia cell line RBL-2H3, and the mouse MC/9 mast cell line.

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  • (PMID = 18432974.001).
  • [ISSN] 1934-368X
  • [Journal-full-title] Current protocols in immunology
  • [ISO-abbreviation] Curr Protoc Immunol
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / ZIA AI000965-04; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
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54. Leung WH, Bolland S: The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol; 2007 Jul 1;179(1):95-102
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  • Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 interacts with the FcepsilonRI beta-chain, Gab2 and Lyn and that unlike SHIP-1, it does not associate with SHC in mast cells.


55. Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD: Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. J Pharmacol Exp Ther; 2007 Jul;322(1):332-40
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  • Using rat basophilic leukemia 2H3 cell line (RBL-2H3), we previously established that activation of A(3) adenosine receptors (A(3)AR) stimulates SERT activity via both PKG and p38 MAPK (Zhu et al., 2004a).

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  • (PMID = 17460150.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA07390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Adenosine A3; 0 / Serotonin Plasma Membrane Transport Proteins; 152918-18-8 / N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; 20125-40-0 / N-(1-methyl-2-phenylethyl)adenosine; 333DO1RDJY / Serotonin; 35920-39-9 / Adenosine-5'-(N-ethylcarboxamide); EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; K72T3FS567 / Adenosine
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56. Lessmann E, Leitges M, Huber M: A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol; 2006 May;18(5):767-73
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  • A critical role of PKC-epsilon in antigen-triggered activation of various signaling pathways was observed in basophilic leukemia cells.


57. Rettig JR, Folch A: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem; 2005 Sep 1;77(17):5628-34
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  • We have characterized microwell occupancy by cells for a range of microwell dimensions and seeding parameters and optimized it for fibroblasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cell).

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  • (PMID = 16131075.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R21DC006465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats

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  • (PMID = 15569773.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / MAIR-I, rat; 0 / Receptors, IgE; 0 / Receptors, Polymeric Immunoglobulin; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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59. Qu X, Li Y, Liu J, Xu L, Zhang Y, Hu X, Hou K, Liu Y: Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Mol Cell Biochem; 2010 Jul;340(1-2):107-14
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  • [Title] Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents, Phytogenic / pharmacology. Apoptosis / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Mitogen-Activated Protein Kinase Kinases / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-cbl / metabolism

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  • (PMID = 20177738.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Enzyme Inhibitors; 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 6.3.2.- / Proto-Oncogene Proteins c-cbl; EC 6.3.2.19 / Cblb protein, rat
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60. Yang W, Chen J, Zhou L: Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol; 2009;28(3):223-30
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  • [Title] Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells.
  • In the present work, a mast cell line (rat basophilic leukemia cells, RBL-2H3) was used in vitro to study cellular responses to the stimulus of shear stress generated by a rotating rotor in a cell dish.
  • [MeSH-minor] Animals. Calcium Channels / drug effects. Calcium Channels / physiology. Calcium Signaling / drug effects. Calcium Signaling / physiology. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Indicators and Reagents / pharmacology. Leukemia, Basophilic, Acute. Microcirculation. Rats. Ruthenium Red / pharmacology. Stress, Mechanical. TRPV Cation Channels / antagonists & inhibitors. TRPV Cation Channels / metabolism

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  • (PMID = 19888909.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Indicators and Reagents; 0 / TRPV Cation Channels; 0 / Trpv4 protein, rat; 11103-72-3 / Ruthenium Red; 820484N8I3 / Histamine; SY7Q814VUP / Calcium
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61. Xu F, Matsuda H, Hata H, Sugawara K, Nakamura S, Yoshikawa M: Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chem Pharm Bull (Tokyo); 2009 Oct;57(10):1089-95
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  • [Title] Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides.
  • The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined.
  • [MeSH-major] Benzofurans / chemistry. Cell Degranulation / drug effects. Cissus / chemistry. Flavonoids / chemistry. Leukemia / metabolism. Stilbenes / chemistry

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  • (PMID = 19801863.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Flavonoids; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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62. Kokandakar HR, Tembhare PR, Mamoon A, Mulay VM, Bhople KS: Acute basophilic leukaemia: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):443-6

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  • [Title] Acute basophilic leukaemia: a case report.
  • Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease.
  • We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
  • [MeSH-major] Leukemia, Basophilic, Acute / diagnosis
  • [MeSH-minor] Adolescent. Coloring Agents. Gene Rearrangement. Histone-Lysine N-Methyltransferase. Humans. Male. Myeloid-Lymphoid Leukemia Protein / genetics. Staining and Labeling. Tolonium Chloride

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  • (PMID = 17883105.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; 15XUH0X66N / Tolonium Chloride; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
  • [Number-of-references] 11
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63. Hochwallner H, Schulmeister U, Swoboda I, Balic N, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, van Tol EA, Valenta R, Spitzauer S: Microarray and allergenic activity assessment of milk allergens. Clin Exp Allergy; 2010 Dec;40(12):1809-18

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  • The allergenic activity of the individual allergens was tested using patients' sera for loading rat basophil leukaemia cells (RBL) expressing the α-chain of the human receptor FcεRI.

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20860558.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / Milk Proteins; 0 / Receptors, Fc; 37341-29-0 / Immunoglobulin E
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64. Chandrasekaran CV, Gupta A, Agarwal A: Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol; 2010 May 27;129(2):203-7
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  • MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20307638.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Plant Extracts; 1HGW4DR56D / Leukotriene B4; 37H9VM9WZL / Calcimycin
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65. Motojima H, Yamada P, Han J, Ozaki M, Shigemori H, Isoda H: Properties of fulvic acid extracted from excess sludge and its inhibiting effect on beta-hexosaminidase release. Biosci Biotechnol Biochem; 2009 Oct;73(10):2210-6

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  • The biological properties of fulvic acid from excess sludge and solubilized excess sludge showed an inhibitory effect on beta-hexosaminidase release at the antigen-antibody binding stage and antigen-receptor binding stage by using rat basophilic leukemia cells.

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  • (PMID = 19809201.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies; 0 / Benzopyrans; 0 / Sewage; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; XII14C5FXV / fulvic acid
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66. Borges JP, Culerrier R, Aldon D, Barre A, Benoist H, Saurel O, Milon A, Didier A, Rougé P: GATEWAY technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3). Protein Expr Purif; 2010 Apr;70(2):277-82

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  • The reactivity of rMal d 3 towards IgE from apple allergic patients and in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits.

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  • [Copyright] (c) 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19778615.001).
  • [ISSN] 1096-0279
  • [Journal-full-title] Protein expression and purification
  • [ISO-abbreviation] Protein Expr. Purif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Carrier Proteins; 0 / Mal d 3 allergen; 0 / Recombinant Proteins; 0 / lipid transfer protein
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67. Ayuso R, Grishina G, Ibáñez MD, Blanco C, Carrillo T, Bencharitiwong R, Sánchez S, Nowak-Wegrzyn A, Sampson HA: Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. J Allergy Clin Immunol; 2009 Jul;124(1):114-20
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  • BACKGROUND: Shellfish allergy is a long-lasting disorder usually persisting throughout life.
  • A functional assay with a rat basophilic leukemia cell line was used to determine the capacity for mediator release induced by SCP.

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  • (PMID = 19523674.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 05931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Calcium-Binding Proteins; 0 / Recombinant Proteins; 37341-29-0 / Immunoglobulin E; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases
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68. Blanc F, Bernard H, Alessandri S, Bublin M, Paty E, Leung SA, Patient KA, Wal JM: Update on optimized purification and characterization of natural milk allergens. Mol Nutr Food Res; 2008 Nov;52 Suppl 2:S166-75
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  • The purified proteins also demonstrated the ability to provoke the degranulation of humanized rat basophilic leukaemia cells.

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  • (PMID = 18504704.001).
  • [ISSN] 1613-4133
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / Lactoglobulins; 9013-90-5 / Lactalbumin
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69. Curtis T, Naal RM, Batt C, Tabb J, Holowka D: Development of a mast cell-based biosensor. Biosens Bioelectron; 2008 Feb 28;23(7):1024-31
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  • Rat basophilic leukemia (RBL) mast cells offer excellent potential for biosensor applications because they are robust and undergo a dramatic exocytotic response within minutes of antigen addition.

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  • (PMID = 18055192.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI022449-13; United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / AI 22449; United States / NIAID NIH HHS / AI / R01 AI022449-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS40874; NLM/ PMC2269709
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70. Chen HH, Purtteman JJ, Heimfeld S, Folch A, Gao D: Development of a microfluidic device for determination of cell osmotic behavior and membrane transport properties. Cryobiology; 2007 Dec;55(3):200-9
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  • During experiments, rat basophilic leukemia (RBL-1 line) cells were injected into the inlet of the device, allowed to flow downstream, and were trapped within a perfusion chamber.

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  • (PMID = 17889847.001).
  • [ISSN] 1090-2392
  • [Journal-full-title] Cryobiology
  • [ISO-abbreviation] Cryobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dimethylpolysiloxanes; 0 / Silicones; 059QF0KO0R / Water; 63148-62-9 / baysilon
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71. Alvarez-Errico D, Sayós J, López-Botet M: The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. J Immunol; 2007 Jan 15;178(2):808-16
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  • In the present study, immunoprecipitation analysis revealed that both the p85alpha subunit of PI3K and Src homology region 2 domain-containing phosphatase-1 could be recruited by IREM-1 in transfected cells as well as in the U937 monocytic leukemia cells, which constitutively express the receptor.
  • By assaying the ability of different IREM-1 mutants to regulate the secretion of beta-hexosaminidase induced via FcRepsilonI in rat basophilic leukemia cells, both Y205 and Y249 appeared crucial for IREM-1-mediated inhibition.
  • Remarkably, engagement of an IREM-1 mutant (Y(205,249,284)F), which did not recruit Src homology region 2 domain-containing phosphatase-1 and lost its inhibitory function, induced rat basophilic leukemia cell degranulation.

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  • (PMID = 17202342.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / CD300C protein, human; 0 / GRB2 Adaptor Protein; 0 / Membrane Glycoproteins; 0 / Protein Subunits; 0 / Receptors, IgE; 42HK56048U / Tyrosine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.16 / Protein Phosphatase 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6
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72. Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, Wang MW: The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol; 2006 Nov 15;177(10):7050-8
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  • More recent studies have shown that CsA also inhibits fMLF-induced degranulation in differentiated HL-60 promyelocytic leukemia cells.
  • In this study we used human neutrophils, differentiated HL-60 cells, and rat basophilic leukemia (RBL)-2H3 cells expressing human FPR (RBL-FPR) to identify the action site of CsA.


73. Brown SL, Jala VR, Raghuwanshi SK, Nasser MW, Haribabu B, Richardson RM: Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. J Immunol; 2006 Sep 1;177(5):3242-9
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  • Rat basophilic leukemia cell line (RBL-2H3) stably expressing wild-type PAFR, PAFR-G alpha(i3), or PAFR-G alpha(q) was generated and characterized.

  • Guide to Pharmacology. gene/protein/disease-specific - PAF receptor - data and references .
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  • (PMID = 16920964.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-38910; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Activating Factor; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Interleukin-8A; 0 / platelet activating factor receptor; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; SY7Q814VUP / Calcium
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74. Parusel I, Kahl S, Braasch F, Glowacki G, Halverson GR, Reid ME, Schawalder A, Ortolan E, Funaro A, Malavasi F, Hardie D, Halder S, Buckley CD, Haag F, Koch-Nolte F: A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cell Immunol; 2005 Jul-Aug;236(1-2):59-65
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  • The mAbs reacted weakly also with human umbilical vein endothelial cells and the basophilic leukemia KU-812.

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  • (PMID = 16168396.001).
  • [ISSN] 0008-8749
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL54459
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cell Cycle Proteins; 0 / GML protein, human; 0 / GPI-Linked Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / ART4 protein, human
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75. Linhart B, Hartl A, Jahn-Schmid B, Verdino P, Keller W, Krauth MT, Valent P, Horak F, Wiedermann U, Thalhamer J, Ebner C, Kraft D, Valenta R: A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol; 2005 May;115(5):1010-6
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  • Immune responses to the hybrid molecule were studied in BALB/c mice and rat basophil leukemia assays.
  • IgG antibodies induced by vaccination with the hybrid blocked immediate allergic reactions, as demonstrated by rat basophil degranulation assays in a murine model of grass pollen allergy.

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  • (PMID = 15867859.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin G; 0 / Recombinant Fusion Proteins; 0 / Vaccines; 0 / Vaccines, DNA
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76. Edel JB, Wu M, Baird B, Craighead HG: High spatial resolution observation of single-molecule dynamics in living cell membranes. Biophys J; 2005 Jun;88(6):L43-5
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  • In this letter we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled cell membrane component on a surface containing zero-mode waveguides (ZMWs).

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  • (PMID = 15821167.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbocyanines; 0 / Fluorescent Dyes; 40957-95-7 / 3,3'-dioctadecylindocarbocyanine
  • [Other-IDs] NLM/ PMC1305672
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77. Aneiros E, Philipp S, Lis A, Freichel M, Cavalié A: Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells. J Immunol; 2005 Jan 1;174(1):119-30
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  • Using rat basophilic leukemia (RBL) mast cells and murine bone marrow-derived mast cells, we examine the role of Na(+)/Ca(2+) exchangers.

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  • (PMID = 15611234.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sodium-Calcium Exchanger
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78. Jala VR, Shao WH, Haribabu B: Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. J Biol Chem; 2005 Feb 11;280(6):4880-7
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  • These mutants expressed in rat basophilic leukemia RBL-2H3 cells bound LTB4 with similar affinity and activated all of the known functional activities of BLT1, albeit at different levels.

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  • (PMID = 15561704.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-43184; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arrestins; 0 / Epitopes; 0 / Ligands; 0 / Receptors, Leukotriene B4; 0 / beta-arrestin; 147336-22-9 / Green Fluorescent Proteins; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; OF5P57N2ZX / Alanine; SY7Q814VUP / Calcium
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79. Evans NE, Forth MK, Simpson AK, Mason MJ: Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity. Biochim Biophys Acta; 2005 Dec 10;1718(1-2):32-43
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  • [Title] Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity.
  • Using a combination of fluorescence measurements of intracellular Ca(2+) ion concentration ([Ca(2+)](i)) and membrane potential we have investigated the sensitivity to serine/threonine phosphatase inhibition of Ca(2+) entry stimulated by activation of the Ca(2+) release-activated Ca(2+) (CRAC) entry pathway in rat basophilic leukemia cells.
  • [MeSH-minor] Animals. Boron Compounds / pharmacology. Cations, Divalent / metabolism. Cells, Cultured. Ion Transport / drug effects. Leukemia, Basophilic, Acute. Manganese / metabolism. Membrane Potentials / drug effects. Protein Phosphatase 1. Rats. Thapsigargin / pharmacology

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  • (PMID = 16297373.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-aminoethoxydiphenyl borate; 0 / Boron Compounds; 0 / Cations, Divalent; 0 / Enzyme Inhibitors; 0 / Oxazoles; 101932-71-2 / calyculin A; 1W21G5Q4N2 / Okadaic Acid; 42Z2K6ZL8P / Manganese; 67526-95-8 / Thapsigargin; EC 3.1.3.16 / Phosphoprotein Phosphatases; EC 3.1.3.16 / Protein Phosphatase 1; SY7Q814VUP / Calcium
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80. Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Koshimizu S, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y: Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. J Agric Food Chem; 2010 Jun 23;58(12):7149-57
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  • [Title] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Degranulation / drug effects. Cell Line, Tumor. Disease Models, Animal. Histamine Release / drug effects. Humans. Male. Mice. Mice, Inbred ICR. Quercus / chemistry. Quercus / immunology. Rats. Skin / immunology

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  • (PMID = 20507065.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts; 37341-29-0 / Immunoglobulin E
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81. Horny HP, Sotlar K, Stellmacher F, Krokowski M, Agis H, Schwartz LB, Valent P: The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers. J Clin Pathol; 2006 Mar;59(3):298-302

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  • AIMS: Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis.
  • METHODS: A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows).
  • RESULTS: In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML).
  • The basophil specific antigen 2D7 was only detected in CD34/Kit negative TROCI-BM cells in two patients with CMLba.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Basophils / chemistry. Biomarkers / analysis. Cell Lineage. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Leukemia, Mast-Cell / diagnosis. Male. Mast Cells / chemistry. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / genetics. Receptors, Interleukin-2 / analysis. Retrospective Studies. Tryptases

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  • (PMID = 16505282.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.59 / Tryptases
  • [Other-IDs] NLM/ PMC1860329
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82. Cho Y, Jang Y, Yang YD, Lee CH, Lee Y, Oh U: TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium; 2010 Oct;48(4):202-8
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  • Here, we report that TRPM8 is expressed in the basophilic leukemia mast cell line, RBL-2H3, and that exposure to menthol or low temperatures induced Ca(2+) influx in RBL-2H3 cells, which was reversed by a TRPM8 blocker.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20934218.001).
  • [ISSN] 1532-1991
  • [Journal-full-title] Cell calcium
  • [ISO-abbreviation] Cell Calcium
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Fluorescent Dyes; 0 / RNA, Small Interfering; 0 / TRPM Cation Channels; 0 / Xanthenes; 121714-13-4 / Fluo-3; 1490-04-6 / Menthol; SY7Q814VUP / Calcium
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83. Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K: Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. Peptides; 2010 Nov;31(11):2109-13

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  • Rat peritoneal mast cells and rat basophilic leukemia (RBL-2H3) cells did not express the ghrelin receptor GHSR1a, suggesting that histamine release induced by ghrelin occurs via a receptor-independent mechanism.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20691233.001).
  • [ISSN] 1873-5169
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones; 0 / Receptors, Ghrelin; 0 / obestatin, rat; EC 2.4.2.31 / Pertussis Toxin
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84. Cui Y, Hou X, Chen J, Xie L, Yang L, Le Y: Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in THP-1 human monocytes. J Nutr; 2010 Feb;140(2):377-81
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  • Similarly, sesamin inhibited FPR-transfected rat basophilic leukemia cell [epitope-tagged human FPR (ETFR) cell] migration toward fMLF (P < 0.01).
  • [MeSH-minor] Animals. Bacteria / metabolism. Basophils / drug effects. Bucladesine. Calcium / metabolism. Cell Line. Cell Line, Tumor. Dose-Response Relationship, Drug. Humans. Inflammation / chemically induced. Inflammation / drug therapy. Inflammation / metabolism. Leukemia / drug therapy. Mice. Mice, Inbred C57BL. Mitogen-Activated Protein Kinase 1 / metabolism. Models, Animal. N-Formylmethionine Leucyl-Phenylalanine. NF-kappa B / antagonists & inhibitors. Phosphorylation. Phytotherapy. Rats. Receptors, Formyl Peptide / metabolism. Signal Transduction / drug effects

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  • (PMID = 20032476.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Dioxoles; 0 / Lignans; 0 / NF-kappa B; 0 / Plant Extracts; 0 / Receptors, Formyl Peptide; 59880-97-6 / N-Formylmethionine Leucyl-Phenylalanine; 63X7MBT2LQ / Bucladesine; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; S7946O4P76 / sesamin; SY7Q814VUP / Calcium
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85. Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, Edwards BS: Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry A; 2009 Mar;75(3):253-63
The Lens. Cited by Patents in .

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  • U937 cells expressing FPR and rat basophil leukemia (RBL) cells expressing FPRL1 were tested together in a "duplex" format.

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  • [Copyright] 2008 International Society for Advancement of Cytometry.
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  • (PMID = 18785269.001).
  • [ISSN] 1552-4930
  • [Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology
  • [ISO-abbreviation] Cytometry A
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / U54 MH074425; United States / NIMH NIH HHS / MH / R03 MH076381-01; United States / NIMH NIH HHS / MH / MH076381-01; United States / NIMH NIH HHS / MH / R03 MH076381; United States / NIMH NIH HHS / MH / U54 MH074425-01
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemotactic Factors; 0 / FPR2 protein, human; 0 / Fluorescent Dyes; 0 / Ligands; 0 / Molecular Probes; 0 / Receptors, Formyl Peptide; 0 / Receptors, Lipoxin
  • [Other-IDs] NLM/ NIHMS76367; NLM/ PMC2645486
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86. Fowler CJ, Ghafouri N: Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? Pharmacol Res; 2008 Jul;58(1):72-6
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  • The selective fatty acid amide hydrolase inhibitor URB597 (3'-(aminocarbamoyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate) completely blocked the hydrolysis of anandamide and reduced its uptake by about half in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 18675915.001).
  • [ISSN] 1043-6618
  • [Journal-full-title] Pharmacological research
  • [ISO-abbreviation] Pharmacol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Biphenyl Compounds; 0 / Cannabinoid Receptor Modulators; 0 / Carbamates; 0 / Endocannabinoids; 0 / Glycerides; 0 / Polyunsaturated Alkamides; 0 / URB602; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 53847-30-6 / 2-arachidonylglycerol; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
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87. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS: Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem; 2007 Mar 23;282(12):9105-16
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

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  • Store-operated calcium entry (SOCE) is a ubiquitous mechanism that is mediated by distinct SOC channels, ranging from the highly selective calcium release-activated Ca2+ (CRAC) channel in rat basophilic leukemia and other hematopoietic cells to relatively Ca2+-selective or non-selective SOC channels in other cells.

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  • (PMID = 17224452.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE017102-06A1; United States / NIDCR NIH HHS / DE / R01 DE017102; United States / NIDCR NIH HHS / DE / R01 DE017102-03; United States / NCRR NIH HHS / RR / RR017699-077011; United States / NIDCR NIH HHS / DE / R01 DE017102-01A1; United States / NIDCR NIH HHS / DE / R01 DE017102-02; United States / NIDCR NIH HHS / DE / DE017102; United States / NCRR NIH HHS / RR / P20 RR017699; United States / NIGMS NIH HHS / GM / GM07525; United States / NCRR NIH HHS / RR / P20 RR017699-077011; United States / NIDCR NIH HHS / DE / R01 DE017102-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / STIM1 protein, human; 0 / Stim1 protein, mouse; 67526-95-8 / Thapsigargin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS112595; NLM/ PMC3309402
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88. Lehmann K, Schweimer K, Reese G, Randow S, Suhr M, Becker WM, Vieths S, Rösch P: Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions. Biochem J; 2006 May 1;395(3):463-72
The Lens. Cited by Patents in .

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  • Even though IgE antibody-binding capacity was reduced by protease treatment, the mediator release from a functional equivalent of a mast cell or basophil, the humanized RBL (rat basophilic leukaemia) cell, demonstrated that this reduction in IgE antibody-binding capacity does not necessarily translate into reduced allergenic potency.

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  • (PMID = 16372900.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 1W2Q
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / Ara h 6 allergen, Arachis hypogaea; 0 / Glycoproteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; EC 3.4.- / Peptide Hydrolases
  • [Other-IDs] NLM/ PMC1462689
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89. Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM: Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. J Natl Cancer Inst; 2005 Jun 1;97(11):823-35
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  • Endogenous FPR agonist activity released by necrotic tumor cells was assessed by measuring FPR activation in an FPR-transfected basophil leukemia cell line and live U-87 cells.

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  • (PMID = 15928303.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 0 / Receptors, Formyl Peptide; 0 / Vascular Endothelial Growth Factor A
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90. Ueda N, Tsuboi K, Lambert DM: A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology; 2005 Jun;48(8):1079-85
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  • The inhibitor was a useful tool to distinguish the acid amidase from FAAH with rat basophilic leukemia (RBL-1) cells that express both the enzymes.

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  • (PMID = 15910884.001).
  • [ISSN] 1873-7064
  • [Journal-full-title] Neuropharmacology
  • [ISO-abbreviation] Neuropharmacology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Ethanolamines; 0 / Organophosphonates; 0 / Palmitic Acids; 0 / methyl arachidonylfluorophosphonate; 57KD15003I / Phenylmethylsulfonyl Fluoride; 6R8T1UDM3V / palmidrol; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / N-acylethanolamine amidohydrolase; EC 3.5.1.- / fatty-acid amide hydrolase; T8ID5YZU6Y / Dithiothreitol
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91. Hashimoto Y, Arai I, Tanaka M, Nakaike S: Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. J Pharmacol Sci; 2005 May;98(1):90-3
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  • Effects of prostaglandin (PG) D(2), PGE(2), and PGI(2) on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined.

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  • (PMID = 15879676.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E; RXY07S6CZ2 / Prostaglandin D2
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92. Jolly PS, Bektas M, Watterson KR, Sankala H, Payne SG, Milstien S, Spiegel S: Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood; 2005 Jun 15;105(12):4736-42
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  • Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degranulation as well as migration toward antigen.

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  • (PMID = 15741218.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AIS0094; United States / NCI NIH HHS / CA / P30 CA16059
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Culture Media, Serum-Free; 0 / Ligands; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / Receptors, Lysosphingolipid; 37341-29-0 / Immunoglobulin E; 37589-80-3 / Guanosine 5'-O-(3-Thiotriphosphate); EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunit, Gi2; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; EC 3.6.5.1 / Gnai2 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC1894993
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93. Castellani ML, Petrarca C, Frydas S, Conti CM, Salini V, Conti P, Shanmugham LN: Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers; 2006 Oct-Dec;21(4):211-7
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  • [Title] Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation.
  • [MeSH-major] Chemokine CCL5 / pharmacology. Leukemia, Basophilic, Acute / metabolism. Prostaglandin D2 / biosynthesis

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  • (PMID = 17177158.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Chemokine CCL5; RXY07S6CZ2 / Prostaglandin D2; XXE1CET956 / Indomethacin
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94. Tang G, Woods LJ, Wang SA, Brettler D, Andersen M, Miron PM, Pechet L, Woda BA, Hao S: Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm. Hum Pathol; 2009 Aug;40(8):1194-9
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  • [Title] Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm.
  • Chronic basophilic leukemia is a rare and poorly characterized entity.
  • [MeSH-major] Basophils / pathology. Leukemia, Myeloid, Chronic-Phase / pathology

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  • (PMID = 19427022.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ETS translocation variant 6 protein; 0 / Proto-Oncogene Proteins c-ets; 0 / Repressor Proteins
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95. Pathak AK, Helm BA: Proteomic identification and characterization of secreted N-glycosylated NPC2 following cross-linking of the high-affinity receptor for IgE on mast cells. Cell Biol Int; 2010 Apr;34(4):353-9
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  • A proteomic screen applied to the detection of proteins secreted by the model rat mast cell line, RBL-2H3 (rat basophilic leukaemia, subline 2H3.1), led to the identification of the cholesterol-binding glycoprotein, NPC2/RE1 (Niemann-Pick Type C2/epididymal secretory protein 1).

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  • (PMID = 20001954.001).
  • [ISSN] 1095-8355
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Antigens, Dermatophagoides; 0 / Carrier Proteins; 0 / Cd63 protein, rat; 0 / Cross-Linking Reagents; 0 / Epididymal Secretory Proteins; 0 / Erabp protein, rat; 0 / Glycoproteins; 0 / NPC2 protein, rat; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, IgE
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96. Huang YF, Liu H, Xiong X, Chen Y, Tan W: Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells. J Am Chem Soc; 2009 Dec 2;131(47):17328-34

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  • We found that both nanoparticle size and surface ligand density play key regulatory roles in the process of membrane antibody-receptor (IgE-Fc epsilonRI) binding and cross-linking, which, in turn, leads to degranulation and consequent release of chemical mediators on rat basophilic leukemia cells.

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  • (PMID = 19929020.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM079359; United States / NIGMS NIH HHS / GM / R01 GM079359-01; None / None / / R01 GM079359-01; United States / NIGMS NIH HHS / GM / R01 GM079359-02; United States / NIGMS NIH HHS / GM / R01 GM079359-03; None / None / / R01 GM079359-02; None / None / / R01 GM079359-01S1; United States / NIGMS NIH HHS / GM / R01 GM079359-01S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
  • [Other-IDs] NLM/ NIHMS158340; NLM/ PMC2786779
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97. Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NA, Wilde JI, Scott L, Corazza GR, Lee K, Sengupta N, Knowles CH, Gunthorpe MJ, McLean PG, MacDonald TT, Kruidenier L: Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol; 2009 Sep 1;183(5):3454-62
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  • The inhibitory activity of the CRAC blocker was investigated through patch-clamp experiments on rat basophilic leukemia cells and fluorometric imaging plate reader intracellular Ca(2+) assays using thapsigargin-stimulated Jurkat T cells and its detailed selectivity profile defined using a range of in vitro radioligand binding and functional assays.
  • We found that the CRAC blocker concentration-dependently inhibited CRAC current in rat basophilic leukemia cells and thapsigargin-induced Ca(2+) influx in Jurkat T cells.


98. Ohga K, Takezawa R, Yoshino T, Yamada T, Shimizu Y, Ishikawa J: The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo. Pulm Pharmacol Ther; 2008;21(2):360-9
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  • YM-58483 inhibited DNP antigen-induced histamine release from and leukotrienes (LTs) production in IgE-primed RBL-2H3 cells, a rat basophilic leukemia cell line, with IC50 values of 460 and 310 nM, respectively.

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  • (PMID = 17977764.001).
  • [ISSN] 1094-5539
  • [Journal-full-title] Pulmonary pharmacology & therapeutics
  • [ISO-abbreviation] Pulm Pharmacol Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide; 0 / Anilides; 0 / Anti-Inflammatory Agents; 0 / Calcium Channel Blockers; 0 / Dinitrophenols; 0 / Leukotrienes; 0 / Phytohemagglutinins; 0 / Serum Albumin, Bovine; 0 / Thiadiazoles; 0 / dinitrophenyl-bovine serum albumin; 0 / phytohemagglutinin-P; 9006-59-1 / Ovalbumin; 9PHQ9Y1OLM / Prednisolone; SY7Q814VUP / Calcium
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99. Ishihara Y, Furuno T, Nakanishi M: The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells. Inflamm Res; 2006 Nov;55(11):465-8
Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .

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  • OBJECTIVE AND DESIGN: We have studied the role of phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) in activation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-major] Calcium Signaling / physiology. Cell Degranulation / physiology. Leukemia, Basophilic, Acute / pathology. Leukemia, Basophilic, Acute / physiopathology. Phosphotransferases (Alcohol Group Acceptor) / physiology

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  • (PMID = 17122963.001).
  • [ISSN] 1023-3830
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens; 0 / RNA, Messenger; 0 / Receptors, IgE; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.67 / phosphatidylinositol phosphate 4-kinase
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100. Tapper H, Källquist L, Johnsson E, Persson AM, Hansson M, Olsson I: Neutrophil elastase sorting involves plasma membrane trafficking requiring the C-terminal propeptide. Exp Cell Res; 2006 Nov 1;312(18):3471-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we investigated the role of the C-terminal pro-peptide in trafficking of NE by expressing, in rat basophilic leukemia (RBL) cells, both wild-type NE and the mutant NE/Delta248-267, which lacks the C-terminal pro-peptide.

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  • (PMID = 16950244.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Peptides; 0 / Protein Precursors; EC 3.4.21.37 / Leukocyte Elastase
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