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6. Ryu H, Walker JK, Kim S, Koo N, Barak LS, Noguchi T, Kang BY, Kim KM: Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. Br J Pharmacol; 2008 Jul;154(5):1035-46
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • EXPERIMENTAL APPROACH: In rat basophilic leukaemia (RBL-2H3) cells, the effects of directly inhibiting M2PK or preventing the FcvarepsilonRI-mediated inhibition of M2PK (disinhibition) on degranulation was measured by hexosaminidase release.

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  • (PMID = 18587448.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Receptors, IgE; 9006-59-1 / Ovalbumin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.40 / Pyruvate Kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.13 / Protein Kinase C; EC 3.2.1.- / Hexosaminidases; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2451040
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7. Zhou Y, Wu X, Wang T, Ming T, Wang PN, Zhou LW, Chen JY: A comparison study of detecting gold nanorods in living cells with confocal reflectance microscopy and two-photon fluorescence microscopy. J Microsc; 2010 Feb;237(2):200-7
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  • Two-photon fluorescence microscopy and confocal reflectance microscopy were compared to detect intracellular gold nanorods in rat basophilic leukaemia cells.

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  • (PMID = 20096050.001).
  • [ISSN] 1365-2818
  • [Journal-full-title] Journal of microscopy
  • [ISO-abbreviation] J Microsc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7440-57-5 / Gold
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8. Thors L, Belghiti M, Fowler CJ: Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. Br J Pharmacol; 2008 Sep;155(2):244-52
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  • All three compounds reduced the FAAH-dependent uptake of anandamide and its metabolism by intact RBL2H3 basophilic leukaemia cells.

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  • (PMID = 18552875.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Kaempferols; 0 / Polyunsaturated Alkamides; 731P2LE49E / kaempferol; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2538700
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9. Staal-Viliare A, Latger-Cannard V, Didion J, Grégoire MJ, Lecompte T, Jonveaux P, Rio Y: CD203c /CD117-, an useful phenotype profile for acute basophilic leukaemia diagnosis in cases of undifferentiated blasts. Leuk Lymphoma; 2007 Feb;48(2):439-41

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  • [Title] CD203c /CD117-, an useful phenotype profile for acute basophilic leukaemia diagnosis in cases of undifferentiated blasts.
  • [MeSH-major] Blast Crisis / diagnosis. Leukemia, Basophilic, Acute / diagnosis. Phosphoric Diester Hydrolases / blood. Proto-Oncogene Proteins c-kit / blood. Pyrophosphatases / blood

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  • (PMID = 17325915.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ENPP3 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.1.4.- / Phosphoric Diester Hydrolases; EC 3.6.1.- / Pyrophosphatases
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10. Passante E, Ehrhardt C, Sheridan H, Frankish N: In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds. Inflamm Res; 2008;57 Suppl 1:S15-6
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  • [Title] In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds.
  • [MeSH-major] Cell Degranulation / drug effects. Histamine Release / drug effects. Indenes / pharmacology. Leukemia, Basophilic, Acute / immunology. Mast Cells / drug effects

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  • (PMID = 18345510.001).
  • [ISSN] 1023-3830
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Histamine H1 Antagonists, Non-Sedating; 0 / Indenes; 7BA5G9Y06Q / Terfenadine; 9IKM0I5T1E / Quercetin; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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11. Ljubić N, Lang N, Skelin IK, Lasan R, Dominis M, Perković L, Zupanić-Krmek D, Grgurević-Batinica A: Klinefelter syndrome and acute basophilic leukaemia--case report. Coll Antropol; 2010 Jun;34(2):657-60
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  • [Title] Klinefelter syndrome and acute basophilic leukaemia--case report.
  • Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia.
  • We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells.
  • Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias.
  • Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules.
  • There is no consistent chromosomal abnormality identified in this leukaemia.
  • This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome.
  • In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
  • [MeSH-major] Klinefelter Syndrome / complications. Leukemia, Basophilic, Acute / complications

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  • (PMID = 20698148.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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12. Takahashi Y, Yoneyama S, Yamamoto S, Shibahara T, Kadota K: Acute basophilic leukaemia in a calf. Vet Rec; 2006 May 20;158(20):702-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute basophilic leukaemia in a calf.
  • [MeSH-major] Cattle Diseases / diagnosis. Leukemia, Basophilic, Acute / veterinary

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  • (PMID = 16714438.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Blanc F, Bernard H, Alessandri S, Bublin M, Paty E, Leung SA, Patient KA, Wal JM: Update on optimized purification and characterization of natural milk allergens. Mol Nutr Food Res; 2008 Nov;52 Suppl 2:S166-75
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  • The purified proteins also demonstrated the ability to provoke the degranulation of humanized rat basophilic leukaemia cells.

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  • (PMID = 18504704.001).
  • [ISSN] 1613-4133
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / Lactoglobulins; 9013-90-5 / Lactalbumin
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1
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4. Kokandakar HR, Tembhare PR, Mamoon A, Mulay VM, Bhople KS: Acute basophilic leukaemia: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):443-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute basophilic leukaemia: a case report.
  • Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease.
  • We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
  • [MeSH-major] Leukemia, Basophilic, Acute / diagnosis
  • [MeSH-minor] Adolescent. Coloring Agents. Gene Rearrangement. Histone-Lysine N-Methyltransferase. Humans. Male. Myeloid-Lymphoid Leukemia Protein / genetics. Staining and Labeling. Tolonium Chloride

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  • (PMID = 17883105.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; 15XUH0X66N / Tolonium Chloride; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
  • [Number-of-references] 11
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15. Toda M, Nakamura T, Ohbayashi M, Ikeda Y, Dawson M, Richardson RM, Alban A, Leed B, Miyazaki D, Ono SJ: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FcepsilonRI- and/or CCR1-engaged mast cells using protein chip technology. Novartis Found Symp; 2005;271:131-40; discussion 140-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We have found that costimulation with IgE/antigen and CC chemokine ligand 3 (CCL3) enhances degranulation but inhibits chemotaxis of rat basophilic leukaemia (RBL)-2H3 cells expressing human CCR1 (RBL-CCR1 cells).

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  • (PMID = 16605132.001).
  • [ISSN] 1528-2511
  • [Journal-full-title] Novartis Foundation symposium
  • [ISO-abbreviation] Novartis Found. Symp.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / CCR1 protein, human; 0 / CCR3 protein, human; 0 / Ccr1 protein, mouse; 0 / Ccr1 protein, rat; 0 / Ccr3 protein, mouse; 0 / Ccr3 protein, rat; 0 / Chemokines, CC; 0 / Receptors, CCR1; 0 / Receptors, CCR3; 0 / Receptors, Chemokine; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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16. Pathak AK, Helm BA: Proteomic identification and characterization of secreted N-glycosylated NPC2 following cross-linking of the high-affinity receptor for IgE on mast cells. Cell Biol Int; 2010 Apr;34(4):353-9
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  • A proteomic screen applied to the detection of proteins secreted by the model rat mast cell line, RBL-2H3 (rat basophilic leukaemia, subline 2H3.1), led to the identification of the cholesterol-binding glycoprotein, NPC2/RE1 (Niemann-Pick Type C2/epididymal secretory protein 1).

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  • (PMID = 20001954.001).
  • [ISSN] 1095-8355
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Antigens, Dermatophagoides; 0 / Carrier Proteins; 0 / Cd63 protein, rat; 0 / Cross-Linking Reagents; 0 / Epididymal Secretory Proteins; 0 / Erabp protein, rat; 0 / Glycoproteins; 0 / NPC2 protein, rat; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, IgE
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17. Oliver-Vila I, Saborit-Villarroya I, Engel P, Martin M: The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells. Mol Immunol; 2008 Apr;45(8):2138-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here, we show that CD84, a member of the CD150 family of leukocyte receptors, inhibits Fc epsilon RI-mediated mast cell degranulation in CD84-transfected rat basophilic leukaemia-2H3 mast cell line cells (RBL-2H3) through homophilic interaction.

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  • (PMID = 18243321.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD84 protein, human; 0 / Cytokines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Mutant Proteins; 0 / Receptors, IgE; 0 / SH2D1A protein, human; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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18. Thors L, Alajakku K, Fowler CJ: The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. Br J Pharmacol; 2007 Apr;150(7):951-60
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  • KEY RESULTS: The FAAH inhibitor URB597 inhibited the uptake of anandamide into C6 glioma, RBL2H3 basophilic leukaemia cells and P19 embryonic carcinoma cells at incubation time 4 min.

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  • (PMID = 17325653.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Carbamates; 0 / Endocannabinoids; 0 / Polyunsaturated Alkamides; 0 / Protein Kinase Inhibitors; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 1400-61-9 / Nystatin; 4G7DS2Q64Y / Progesterone; 94421-68-8 / anandamide; DH2M523P0H / Genistein; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2013877
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19. Zhou J, Liu DF, Liu C, Kang ZM, Shen XH, Chen YZ, Xu T, Jiang CL: Glucocorticoids inhibit degranulation of mast cells in allergic asthma via nongenomic mechanism. Allergy; 2008 Sep;63(9):1177-85
Hazardous Substances Data Bank. HISTAMINE .

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  • Using whole-cell patch clamp and fluorometric assay, we examined GCs' nongenomic effect on IgE-mediated exocytosis and histamine release of rat basophilic leukaemia-2H3 mast cells.

  • MedlinePlus Health Information. consumer health - Steroids.
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  • (PMID = 18699934.001).
  • [ISSN] 1398-9995
  • [Journal-full-title] Allergy
  • [ISO-abbreviation] Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Glucocorticoids; 820484N8I3 / Histamine
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20. Fowler CJ, Ghafouri N: Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? Pharmacol Res; 2008 Jul;58(1):72-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The selective fatty acid amide hydrolase inhibitor URB597 (3'-(aminocarbamoyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate) completely blocked the hydrolysis of anandamide and reduced its uptake by about half in RBL2H3 basophilic leukaemia cells.

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  • (PMID = 18675915.001).
  • [ISSN] 1043-6618
  • [Journal-full-title] Pharmacological research
  • [ISO-abbreviation] Pharmacol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Benzamides; 0 / Biphenyl Compounds; 0 / Cannabinoid Receptor Modulators; 0 / Carbamates; 0 / Endocannabinoids; 0 / Glycerides; 0 / Polyunsaturated Alkamides; 0 / URB602; 0 / cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester; 53847-30-6 / 2-arachidonylglycerol; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
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21. Vandevoorde S, Jonsson KO, Labar G, Persson E, Lambert DM, Fowler CJ: Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. Br J Pharmacol; 2007 Jan;150(2):186-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis was also observed for intact RBL2H3 basophilic leukaemia cells.

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  • (PMID = 17143303.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Arachidonic Acids; 0 / Benzoxazines; 0 / Biphenyl Compounds; 0 / Endocannabinoids; 0 / Glycerides; 0 / Polyunsaturated Alkamides; 0 / Recombinant Proteins; 0 / URB 754; 0 / URB602; 94421-68-8 / anandamide; 9A2389K694 / 2-oleoylglycerol; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2042901
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22. Lenman A, Fowler CJ: Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. Br J Pharmacol; 2007 Aug;151(8):1343-51
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • EXPERIMENTAL APPROACH: Fatty acid amide hydrolase activity was measured in rat brain homogenates, C6 glioma and RBL2H3 basophilic leukaemia cells.
  • [MeSH-minor] Animals. Brain / enzymology. Brain Neoplasms / enzymology. Brain Neoplasms / pathology. Cell Line, Tumor. Dose-Response Relationship, Drug. Drug Design. Glioma / enzymology. Glioma / pathology. Hydrogen-Ion Concentration. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / pathology. Ligands. Male. Monoacylglycerol Lipases / drug effects. Monoacylglycerol Lipases / metabolism. Rats. Rats, Sprague-Dawley. Receptor, Cannabinoid, CB1 / drug effects. Receptor, Cannabinoid, CB1 / metabolism. Receptor, Cannabinoid, CB2 / drug effects. Receptor, Cannabinoid, CB2 / metabolism. Thiazolidinediones / administration & dosage. Thiazolidinediones / pharmacology

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  • (PMID = 17592505.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Cannabinoid Receptor Modulators; 0 / Endocannabinoids; 0 / Ligands; 0 / PPAR gamma; 0 / Receptor, Cannabinoid, CB1; 0 / Receptor, Cannabinoid, CB2; 0 / Thiazolidinediones; 74772-77-3 / ciglitazone; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ PMC2189817
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23. Vogel L, Lüttkopf D, Hatahet L, Haustein D, Vieths S: Development of a functional in vitro assay as a novel tool for the standardization of allergen extracts in the human system. Allergy; 2005 Aug;60(8):1021-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Rat basophilic leukaemia cells were transfected with cDNA coding for the human high affinity IgE receptor chains.
  • CONCLUSION: A stable 'humanized' basophil cell line was established that will be a useful tool for the standardization and batch control of allergen extracts.

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  • (PMID = 15969682.001).
  • [ISSN] 0105-4538
  • [Journal-full-title] Allergy
  • [ISO-abbreviation] Allergy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Allergens; 0 / DNA, Complementary; 0 / Protein Isoforms; 0 / Receptors, IgE
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24. Gehlhar K, Peters M, Brockmann K, van Schijndel H, Bufe A: Characterization of modified allergen extracts by in vitro beta-hexosaminidase release from rat basophils. Int Arch Allergy Immunol; 2005 Apr;136(4):311-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to test whether the rat basophilic leukaemia (RBL) cell assay (beta-hexosaminidase release by rat basophils upon allergen stimulation) can be adopted to characterize allergoids and to evaluate the assay for testing allergoids and native allergens as well.
  • Their sera were used to sensitize RBL-2H3 cells and measure basophil stimulation induced by different allergen extracts in the presence or absence of various additives.
  • Additives turned out to have diverse effects on the assay, whereas phenol had no measurable effect, alum had an inhibitory effect and glycerol elevated basophil activation.

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel
  • (PMID = 15722642.001).
  • [ISSN] 1018-2438
  • [Journal-full-title] International archives of allergy and immunology
  • [ISO-abbreviation] Int. Arch. Allergy Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Allergoid; 0 / Plant Extracts; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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25. Sordet C, Culerrier R, Granier C, Rancé F, Didier A, Barre A, Rougé P: Expression of Jug r 1, the 2S albumin allergen from walnut (Juglans regia), as a correctly folded and functional recombinant protein. Peptides; 2009 Jul;30(7):1213-21
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both native and recombinant allergens exhibit similar IgE-binding activity and similarly trigger the degranulation of a FcepsilonRI-expressing rat basophilic leukaemia cell line previously treated by IgE-containing sera.

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  • (PMID = 19540419.001).
  • [ISSN] 1873-5169
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Antigens, Plant; 0 / Epitopes; 0 / Recombinant Proteins; 37341-29-0 / Immunoglobulin E
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26. Blanc F, Adel-Patient K, Drumare MF, Paty E, Wal JM, Bernard H: Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy; 2009 Aug;39(8):1277-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: We optimized an in vitro functional assay to assess the capacity of peanut allergens to degranulate humanized rat basophilic leukaemia cells, RBL SX-38 cells, after sensitization by serum IgE from peanut-allergic patients.
  • [MeSH-major] 2S Albumins, Plant / immunology. Allergens / immunology. Antigens, Plant / immunology. Basophil Degranulation Test. Glycoproteins / immunology. Peanut Hypersensitivity / immunology

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  • (PMID = 19538351.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / Ara h 6 allergen, Arachis hypogaea; 0 / Glycoproteins; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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27. Horny HP, Sotlar K, Stellmacher F, Krokowski M, Agis H, Schwartz LB, Valent P: The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers. J Clin Pathol; 2006 Mar;59(3):298-302

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis.
  • METHODS: A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows).
  • RESULTS: In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML).
  • The basophil specific antigen 2D7 was only detected in CD34/Kit negative TROCI-BM cells in two patients with CMLba.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Basophils / chemistry. Biomarkers / analysis. Cell Lineage. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Leukemia, Mast-Cell / diagnosis. Male. Mast Cells / chemistry. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / genetics. Receptors, Interleukin-2 / analysis. Retrospective Studies. Tryptases

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  • (PMID = 16505282.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.59 / Tryptases
  • [Other-IDs] NLM/ PMC1860329
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28. Kaul S, Lüttkopf D, Kastner B, Vogel L, Höltz G, Vieths S, Hoffmann A: Mediator release assays based on human or murine immunoglobulin E in allergen standardization. Clin Exp Allergy; 2007 Jan;37(1):141-50
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

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  • Rat basophilic leukaemia (RBL) cells were passively sensitized with pooled murine allergen-specific IgE-containing sera.

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  • (PMID = 17210052.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Indicators and Reagents; 0 / Reagent Kits, Diagnostic; 37341-29-0 / Immunoglobulin E
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29. Thors L, Fowler CJ: Is there a temperature-dependent uptake of anandamide into cells? Br J Pharmacol; 2006 Sep;149(1):73-81

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  • We have therefore re-examined the temperature-sensitive uptake of anandamide in ND7/23 mouse neuroblastoma x rat dorsal root ganglion neurone hybrid cells and RBL2H3 rat basophilic leukaemia cells.

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  • (PMID = 16865094.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Polyunsaturated Alkamides; 0 / Serum Albumin, Bovine; 9006-59-1 / Ovalbumin; 94421-68-8 / anandamide
  • [Other-IDs] NLM/ PMC1629410
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30. Lehmann K, Schweimer K, Reese G, Randow S, Suhr M, Becker WM, Vieths S, Rösch P: Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions. Biochem J; 2006 May 1;395(3):463-72
The Lens. Cited by Patents in .

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  • Even though IgE antibody-binding capacity was reduced by protease treatment, the mediator release from a functional equivalent of a mast cell or basophil, the humanized RBL (rat basophilic leukaemia) cell, demonstrated that this reduction in IgE antibody-binding capacity does not necessarily translate into reduced allergenic potency.

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  • (PMID = 16372900.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 1W2Q
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 0 / Allergens; 0 / Antigens, Plant; 0 / Ara h 2 allergen, Arachis hypogaea; 0 / Ara h 6 allergen, Arachis hypogaea; 0 / Glycoproteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; EC 3.4.- / Peptide Hydrolases
  • [Other-IDs] NLM/ PMC1462689
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31. Wiche R, Gubesch M, König H, Fötisch K, Hoffmann A, Wangorsch A, Scheurer S, Vieths S: Molecular basis of pollen-related food allergy: identification of a second cross-reactive IgE epitope on Pru av 1, the major cherry (Prunus avium) allergen. Biochem J; 2005 Jan 1;385(Pt 1):319-27
The Lens. Cited by Patents in .

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  • The Pru av 1 mutants were produced as recombinant proteins and characterized for their folding, mAb- and IgE-binding capacity and allergenic potency with a cellular assay using the humanized rat basophilic leukaemia cell line RBL-25/30.

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  • (PMID = 15330760.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Antigens, Plant; 0 / Epitopes; 0 / Pru av 1 allergen, Prunus avium; 37341-29-0 / Immunoglobulin E
  • [Other-IDs] NLM/ PMC1134700
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32. Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK, Radinger M, Her E, Choi WS: Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells. Clin Exp Allergy; 2008 May;38(5):794-804
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  • LECJ reversibly inhibited degranulation in a dose-dependent manner, with IC(50) values of approximately 50 microg/mL for the mast cells, and it also suppressed the expression and secretion of TNF-alpha and IL-4 in rat basophilic leukaemia-2H3 mast cells.

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  • [CommentIn] Clin Exp Allergy. 2008 May;38(5):704-8 [18325033.001]
  • (PMID = 18261158.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Plant Extracts; 37341-29-0 / Immunoglobulin E; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / src-Family Kinases
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33. Albrecht M, Suezer Y, Staib C, Sutter G, Vieths S, Reese G: Vaccination with a Modified Vaccinia Virus Ankara-based vaccine protects mice from allergic sensitization. J Gene Med; 2008 Dec;10(12):1324-33
MedlinePlus Health Information. consumer health - Immunization.

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  • OVA-specific immunoglobulin E(IgE) activity was measured by mediator release from rat basophilic leukaemia cells, whereas specific IgG subclass titers were determined by enzyme-linked immunosorbent assay.

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  • [Copyright] Copyright (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18816482.001).
  • [ISSN] 1521-2254
  • [Journal-full-title] The journal of gene medicine
  • [ISO-abbreviation] J Gene Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Vaccines; 9006-59-1 / Ovalbumin
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34. Laengle UW, Markstein R, Pralet D, Seewald W, Roman D: Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation. Clin Exp Ophthalmol; 2007 Sep-Oct;35(7):645-50
Hazardous Substances Data Bank. TIMOLOL .

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  • METHODS: A rat basophilic leukaemia RBL-2H3 mast cell line was activated via IgE/anti-IgE.

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  • (PMID = 17894685.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Dopamine Agents; 0 / Prostaglandins F, Synthetic; 0 / Quinolines; 0 / Receptors, Dopamine D1; 0 / Receptors, Dopamine D2; 0 / SDZ GLC 756; 2CU6TT9V48 / Leukotriene C4; 37341-29-0 / Immunoglobulin E; 6Z5B6HVF6O / latanoprost; 817W3C6175 / Timolol
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35. Ligresti A, Cascio MG, Pryce G, Kulasegram S, Beletskaya I, De Petrocellis L, Saha B, Mahadevan A, Visintin C, Wiley JL, Baker D, Martin BR, Razdan RK, Di Marzo V: New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br J Pharmacol; 2006 Jan;147(1):83-91
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  • (c) [(14)C]AEA cellular uptake and hydrolysis assays in rat basophilic leukaemia (RBL-2H3) cells;.

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  • (PMID = 16284631.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / R01 DA008904; United States / NIDA NIH HHS / DA / DA-09789; United Kingdom / Multiple Sclerosis Society / / 835; United Kingdom / Multiple Sclerosis Society / / 541; United States / NIDA NIH HHS / DA / P01 DA009789; United States / NIDA NIH HHS / DA / DA-08904
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Neuromuscular Blocking Agents; 0 / Polyunsaturated Alkamides; UR5G69TJKH / anandamide
  • [Other-IDs] NLM/ PMC1615845
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36. Bøgh KL, Kroghsbo S, Dahl L, Rigby NM, Barkholt V, Mills EN, Madsen CB: Digested Ara h 1 has sensitizing capacity in Brown Norway rats. Clin Exp Allergy; 2009 Oct;39(10):1611-21
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  • The sensitizing capacity was evaluated by analyses of specific antibody (IgG1, IgG2a and IgE) responses and ability to trigger mediator release of rat basophilic leukaemia (RBL)-2H3 cells.

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  • (PMID = 19689460.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies; 0 / Antigens, Plant; 0 / Ara h 1 protein, Arachis hypogaea; 0 / Glycoproteins; 0 / Peptides; 0 / Plant Proteins
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37. Reese G, Schicktanz S, Lauer I, Randow S, Lüttkopf D, Vogel L, Lehrer SB, Vieths S: Structural, immunological and functional properties of natural recombinant Pen a 1, the major allergen of Brown Shrimp, Penaeus aztecus. Clin Exp Allergy; 2006 Apr;36(4):517-24

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  • The mediator release experiments using both wild-type and humanized rat basophilic leukaemia 30/25 cells showed that rPen a 1 and nPen a 1 induced a similar level of mast cell activation.
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Basophils / immunology. Cells, Cultured. Circular Dichroism / methods. DNA, Circular / chemistry. Female. Humans. Hypersensitivity / immunology. Immunoglobulin E / immunology. Leukemia / immunology. Mice. Mice, Inbred C3H. Models, Biological. Protein Conformation. Radioallergosorbent Test / methods. Rats. Transfection / methods. Tropomyosin / immunology

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  • (PMID = 16630158.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / DNA, Circular; 0 / Pen a 1 allergen, Penaeus aztecus; 0 / Recombinant Proteins; 0 / Tropomyosin; 37341-29-0 / Immunoglobulin E
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38. Lichtman MA, Segel GB: Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review. Blood Cells Mol Dis; 2005 Nov-Dec;35(3):370-83
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  • [Title] Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.
  • The potential of the transformed (leukemic) multipotential hematopoietic cell to differentiate and mature along any myeloid lineage forms the basis for the phenotypic classification of acute and chronic myelogenous leukemia.
  • Although most cases of leukemia can be classified phenotypically by the dominant lineage expressed, the genotype within each phenotype is heterogeneous.
  • The least common AML phenotypes are a reflection of the least common blood or marrow cell lineages: acute basophilic, acute mast cell, acute eosinophilic, and acute myeloid dendritic cell leukemia.
  • [MeSH-major] Basophils / pathology. Dendritic Cells / pathology. Eosinophils / pathology. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Acute / pathology. Mast Cells / pathology. Myeloid Cells / pathology


39. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y: Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Bioorg Med Chem; 2008 Aug 15;16(16):7592-8
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  • [Title] Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
  • It has been reported that flavonoids isolated from several Citrus have been shown to suppress the degranulation as inferred by histamine release in rat basophilic leukemia RBL-2H3 cells.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Calcium / metabolism. Cell Line, Tumor. Enzyme Activation / drug effects. Histamine Release / drug effects. Immunoblotting. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / metabolism. Leukemia, Basophilic, Acute. Phospholipase C gamma / antagonists & inhibitors. Phospholipase C gamma / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / metabolism. Rats. Reactive Oxygen Species / metabolism. Receptors, IgG / metabolism. Signal Transduction / drug effects. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 18656366.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Flavones; 0 / Intracellular Signaling Peptides and Proteins; 0 / Reactive Oxygen Species; 0 / Receptors, IgG; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Syk kinase; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.1.4.3 / Phospholipase C gamma; SY7Q814VUP / Calcium
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40. Itoh T, Ninomiya M, Nozawa Y, Koketsu M: Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem; 2010 Oct 1;18(19):7052-7
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  • [Title] Chalcone glycosides isolated from aerial parts of Brassica rapa L. 'hidabeni' suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
  • We isolated three chalcone glycosides along with other glycoside constituents from the aerial parts of Brassica rapa L. 'hidabeni' and examined the effects of these compounds on the antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20801664.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens; 0 / Biphenyl Compounds; 0 / Chalcones; 0 / Free Radical Scavengers; 0 / Glycosides; 0 / Picrates; 0 / Plant Extracts; 0 / Reactive Oxygen Species; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl; EC 1.6.3.1 / NADPH Oxidase
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41. Mizuno H, Tsuyama N, Date S, Harada T, Masujima T: Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell. Anal Sci; 2008 Dec;24(12):1525-7
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  • [Title] Live single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leukemia cell.
  • The metabolic pathways and the locations of tryptophan and histidine metabolites were traced by this method for a cultured rat basophil leukemia cell line (RBL-2H3).
  • [MeSH-major] Basophils / metabolism. Basophils / pathology. Histidine / metabolism. Leukemia / metabolism. Leukemia / pathology. Metabolomics. Tryptophan / metabolism

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  • (PMID = 19075459.001).
  • [ISSN] 1348-2246
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 4QD397987E / Histidine; 8DUH1N11BX / Tryptophan
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42. Maruo T, Namikawa K, Kunihiro A, Lynch J, Shida T, Kishikawa S: Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog. J S Afr Vet Assoc; 2009 Dec;80(4):261-3

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  • [Title] Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog.
  • Seventy-two per cent (81360/ml) of the lymphocytes were found to be 12-17 microm in diameter, containing nuclei with mature clumped chromatin and abundant lightly basophilic cytoplasm with a variable number of fine azurophilic granules.
  • Based on these findings this case was diagnosed as LGL leukaemia.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Histiocytic Sarcoma / veterinary. Leukemia, Large Granular Lymphocytic / veterinary

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  • (PMID = 20458870.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] South Africa
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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43. Harata G, He F, Takahashi K, Hosono A, Kawase M, Kubota A, Hiramatsu M, Kaminogawa S: Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Microbiol Immunol; 2010;54(1):54-7

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  • [Title] Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • Sixteen heat-killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells in vitro.
  • [MeSH-major] Basophils / immunology. Bifidobacterium / physiology. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute / immunology
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Line, Tumor. Humans. Intestines / microbiology. Lactobacillus / physiology. Rats. Signal Transduction

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  • (PMID = 20055943.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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44. Kato N, Nakanishi M, Hirashima N: Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J Immunol; 2006 Jul 1;177(1):147-54
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  • [Title] Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
  • Cross-linking of high-affinity IgE receptors by multivalent Ag on mast cells (rat basophilic leukemia (RBL)-2H3) induces the phosphorylation of ITAM motifs of an IgE receptor by Src family tyrosine kinase, Lyn.
  • We obtained flotillin-1 knockdown (KD)(2) rat basophilic leukemia (RBL)-2H3 cells, which express a low level of flotillin-1.
  • [MeSH-minor] Animals. Calcium / metabolism. Calcium Signaling / physiology. Cell Degranulation / physiology. Cell Line, Tumor. Enzyme Activation / physiology. Extracellular Signal-Regulated MAP Kinases / metabolism. Leukemia, Basophilic, Acute / enzymology. Leukemia, Basophilic, Acute / immunology. Leukemia, Basophilic, Acute / metabolism. Membrane Microdomains / enzymology. Membrane Microdomains / immunology. Membrane Microdomains / metabolism. Phosphorylation. Rats. Transfection. Tyrosine / metabolism. src-Family Kinases / metabolism

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  • (PMID = 16785509.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, IgE; 0 / flotillins; 42HK56048U / Tyrosine; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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45. Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M: Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells. Biol Pharm Bull; 2007 Mar;30(3):443-6
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  • [Title] Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.
  • To trigger degranulation, rat basophilic leukemia (RBL)-2H3 cells were passively sensitized using an antiserum collected from ovalbumin (OA) immunized-Brown Norway rats, and the cells were stimulated by treatment with OA.
  • [MeSH-major] Cell Degranulation. Heme Oxygenase-1 / metabolism. Leukemia, Basophilic, Acute / metabolism

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  • (PMID = 17329835.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / 2',7'-dichlorodihydrofluorescein diacetate; 0 / Azo Compounds; 0 / Enzyme Inhibitors; 0 / Fluoresceins; 0 / Free Radical Scavengers; 0 / Metalloporphyrins; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0KAE1U0G7Q / tin mesoporphyrin; 6226-79-5 / ponceau S; 9006-59-1 / Ovalbumin; EC 1.14.99.3 / Heme Oxygenase-1; WYQ7N0BPYC / Acetylcysteine
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46. Pidala J, Pinilla-Ibarz J, Cualing HD: A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Cancer Genet Cytogenet; 2008 Apr 1;182(1):46-9
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  • [Title] A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies.
  • A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13).
  • [MeSH-major] Chromosomes, Human, Pair 7. Chromosomes, Human, Pair 8. Leukemia, Basophilic, Acute / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Translocation, Genetic


47. Barth EE, Hallworth R, Nichols MG: A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells. Photochem Photobiol; 2005 May-Jun;81(3):556-62
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  • [Title] A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells.
  • Photodamage was induced in rat basophilic leukemia cells by either 254-nm UVC light exposure or rose bengal photosensitization.
  • [MeSH-major] Cell Division / radiation effects. Leukemia / pathology. Rose Bengal / toxicity. Ultraviolet Rays / adverse effects

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  • (PMID = 15773792.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Photosensitizing Agents; 1N3CZ14C5O / Rhodamine 123; 1ZPG1ELY14 / Rose Bengal; 36015-30-2 / Propidium; EC 3.1.- / Esterases; G34N38R2N1 / Bromodeoxyuridine; V0YM2B16TS / fluorexon
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48. Okoshi Y, Tahara-Hanaoka S, Nakahashi C, Honda S, Miyamoto A, Kojima H, Nagasawa T, Shibuya K, Shibuya A: Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol; 2005 Jan;17(1):65-72
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  • [Title] Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
  • Here, we demonstrate that the transfectant of rat basophil leukemia RBL-2H3 expressing wild-type MAIR-I is tyrosine phosphorylated and recruits SHP-1 and SHIP upon cross-linking of MAIR-I.
  • [MeSH-minor] Amino Acid Substitution. Animals. Antibodies, Monoclonal / pharmacology. Cell Line, Tumor. Immunoglobulin E / immunology. Leukemia, Basophilic, Acute. Mutation / genetics. Phosphorylation. Protein Tyrosine Phosphatases / metabolism. Rats

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  • (PMID = 15569773.001).
  • [ISSN] 0953-8178
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / MAIR-I, rat; 0 / Receptors, IgE; 0 / Receptors, Polymeric Immunoglobulin; 37341-29-0 / Immunoglobulin E; 42HK56048U / Tyrosine; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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49. Xu F, Matsuda H, Hata H, Sugawara K, Nakamura S, Yoshikawa M: Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chem Pharm Bull (Tokyo); 2009 Oct;57(10):1089-95
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  • [Title] Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides.
  • The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined.
  • [MeSH-major] Benzofurans / chemistry. Cell Degranulation / drug effects. Cissus / chemistry. Flavonoids / chemistry. Leukemia / metabolism. Stilbenes / chemistry

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  • (PMID = 19801863.001).
  • [ISSN] 1347-5223
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Flavonoids; 0 / Stilbenes; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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50. Nakamura R, Nakamura R, Watanabe K, Oka K, Ohta S, Mishima S, Teshima R: Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis. Int Immunopharmacol; 2010 Sep;10(9):1107-12
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  • The amount of released beta-hexosaminidase via high-affinity IgE receptor I (Fc epsilon RI) from rat basophilic leukemia (RBL-2H3) cells was used as an index of degranulation.

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  • [Copyright] (c) 2010 Elsevier B.V. All rights reserved.
  • [CommentIn] Int Immunopharmacol. 2011 Sep;11(9):1386-7 [21481329.001]
  • (PMID = 20601180.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Chemokine CCL2; 0 / Cytokines; 0 / Flavonoids; 0 / Kaempferols; 0 / Plant Extracts; 0 / Receptors, IgE; 207137-56-2 / Interleukin-4; 3CN01F5ZJ5 / chrysin; 731P2LE49E / kaempferol; 9009-62-5 / Propolis; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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51. Huelsenbeck SC, Klose I, Reichenbach M, Huelsenbeck J, Genth H: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. FEBS Lett; 2009 Oct 6;583(19):3133-9
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  • Alternative Ras antibodies including the K-Ras(Mab F234) antibody or the v-H-Ras(Mab Y13-159) antibody recognize Ras proteins regardless of glucosylation. (H/K)Ras are further shown to be more efficaciously glucosylated by TcsL than Rac1 in rat basophilic leukemia cells as well as in a cell-free system.

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  • (PMID = 19744486.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 0 / Bacterial Toxins; 0 / lethal toxin LT, Clostridium sordellii; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / ras Proteins
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52. Sakai S, Sugawara T, Matsubara K, Hirata T: Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors. J Biol Chem; 2009 Oct 9;284(41):28172-9
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  • Fucoxanthin, astaxanthin, zeaxanthin, and beta-carotene significantly inhibited the antigen-induced release of beta-hexosaminidase in rat basophilic leukemia 2H3 cells and mouse bone marrow-derived mast cells.

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  • (PMID = 19700409.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Monoterpenes; 0 / Receptors, IgE; 36-88-4 / Carotenoids; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
  • [Other-IDs] NLM/ PMC2788868
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53. Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T: Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res; 2009 Oct;58(10):705-15
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  • OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells.
  • [MeSH-minor] Animals. Bilirubin / pharmacology. Carbon Monoxide / pharmacology. Cells, Cultured. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Heme Oxygenase (Decyclizing) / metabolism. Leukemia, Basophilic, Acute / metabolism. Leukemia, Basophilic, Acute / pathology. Metalloporphyrins / pharmacology. Mice. Mice, Inbred BALB C. NF-E2-Related Factor 2 / metabolism. Protoporphyrins / pharmacology. Rats. Rats, Wistar

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  • (PMID = 19390785.001).
  • [ISSN] 1420-908X
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Metalloporphyrins; 0 / NF-E2-Related Factor 2; 0 / Protoporphyrins; 14325-05-4 / tin protoporphyrin IX; 7U1EE4V452 / Carbon Monoxide; 9IKM0I5T1E / Quercetin; EC 1.14.14.18 / Heme Oxygenase (Decyclizing); EC 1.14.14.18 / Heme Oxygenase-1; EC 1.14.14.18 / heme oxygenase-2; RFM9X3LJ49 / Bilirubin
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54. Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H: Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med; 2007 Jun;73(7):662-5
MedlinePlus Health Information. consumer health - Herbal Medicine.

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  • Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187.

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  • (PMID = 17538871.001).
  • [ISSN] 0032-0943
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Plant Extracts
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55. Chikamatsu S, Furuno T, Kinoshita Y, Inoh Y, Hirashima N, Teshima R, Nakanishi M: Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Mol Immunol; 2007 Mar;44(7):1490-7
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  • Here we have shown that Cot kinase activity is intimately involved in the high affinity receptor for IgE (FcvarepsilonRI)-mediated nuclear translocation of NF-kappaB1 independent of NF-kappaB-inducing kinase (NIK) in rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17049604.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Luminescent Proteins; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins; 0 / Receptors, IgE; 0 / red fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.11.25 / MAP Kinase Kinase Kinases; EC 2.7.11.25 / Map3k8 protein, rat
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56. Yamaki K, Yoshino S: Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate. Environ Toxicol Pharmacol; 2010 Mar;29(2):183-9

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  • [Title] Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.
  • The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 21787600.001).
  • [ISSN] 1872-7077
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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57. Yang W, Chen J, Zhou L: Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol; 2009;28(3):223-30
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  • [Title] Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells.
  • In the present work, a mast cell line (rat basophilic leukemia cells, RBL-2H3) was used in vitro to study cellular responses to the stimulus of shear stress generated by a rotating rotor in a cell dish.
  • [MeSH-minor] Animals. Calcium Channels / drug effects. Calcium Channels / physiology. Calcium Signaling / drug effects. Calcium Signaling / physiology. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / metabolism. Indicators and Reagents / pharmacology. Leukemia, Basophilic, Acute. Microcirculation. Rats. Ruthenium Red / pharmacology. Stress, Mechanical. TRPV Cation Channels / antagonists & inhibitors. TRPV Cation Channels / metabolism

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  • (PMID = 19888909.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Indicators and Reagents; 0 / TRPV Cation Channels; 0 / Trpv4 protein, rat; 11103-72-3 / Ruthenium Red; 820484N8I3 / Histamine; SY7Q814VUP / Calcium
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58. Källquist L, Rosén H, Nordenfelt P, Calafat J, Janssen H, Persson AM, Hansson M, Olsson I: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. Exp Cell Res; 2010 Nov 15;316(19):3182-96
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  • The NE aminoacid residue Y199 of a proposed NE sorting motif that interacts with AP-3 [2] was not required for proNE processing, sorting or endocytosis in rat basophilic leukemia (RBL) cells expressing heterologous Y199-deleted proNE; this suggests operation of another AP-3-link for proNE targeting.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20828556.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Protein Complex 3; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / CD63 protein, human; 0 / Cd63 protein, rat; 0 / Enzyme Precursors; 0 / Platelet Membrane Glycoproteins; 42HK56048U / Tyrosine; EC 3.4.21.37 / Leukocyte Elastase; EC 3.4.21.76 / Myeloblastin; EC 5.2.1.- / Tacrolimus Binding Proteins
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59. Shaik GM, Dráberová L, Heneberg P, Dráber P: Vacuolin-1-modulated exocytosis and cell resealing in mast cells. Cell Signal; 2009 Aug;21(8):1337-45
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  • Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis.

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  • (PMID = 19376224.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Heterocyclic Compounds with 4 or More Rings; 0 / Receptors, IgE; 0 / vacuolin-1; SY7Q814VUP / Calcium
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60. Nowak-Wegrzyn AH, Bencharitiwong R, Schwarz J, David G, Eggleston P, Gergen PJ, Liu AH, Pongracic JA, Sarpong S, Sampson HA: Mediator release assay for assessment of biological potency of German cockroach allergen extracts. J Allergy Clin Immunol; 2009 Apr;123(4):949-955.e1
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  • OBJECTIVE: We investigated the utility of a mediator release assay based on rat basophil leukemia (RBL) cells for comparing the potency of German cockroach extracts.

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  • (PMID = 19348929.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / K23 AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25482; United States / NIAID NIH HHS / AI / N01 AI025496; United States / NIAID NIH HHS / AI / AI 059318; United States / NIAID NIH HHS / AI / N01AI25496; United States / NIAID NIH HHS / AI / N01 AI025482; United States / NIAID NIH HHS / AI / K23 AI059318; United States / NIAID NIH HHS / AI / N01AI25482; United States / NIAID NIH HHS / AI / AI059318-01A1; United States / NIAID NIH HHS / AI / N01-AI-25496
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E; EC 3.2.1.- / Hexosaminidases
  • [Other-IDs] NLM/ NIHMS109184; NLM/ PMC2952833
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61. Sun J, Wu Y, Wang J, Ma F, Liu X, Li Q: Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica. Biochimie; 2008 Nov-Dec;90(11-12):1760-8

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  • It mediated histamine release from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 18822340.001).
  • [ISSN] 1638-6183
  • [Journal-full-title] Biochimie
  • [ISO-abbreviation] Biochimie
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Recombinant Proteins; 0 / tumor protein, translationally-controlled 1
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62. Wagner S, Radauer C, Bublin M, Hoffmann-Sommergruber K, Kopp T, Greisenegger EK, Vogel L, Vieths S, Scheiner O, Breiteneder H: Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol; 2008 Jan;121(1):246-52

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  • Isoform structures were compared and related to IgE-binding inhibitory capacities and induction of mediator release in human Fcvarepsilon receptor transformed rat basophilic leukemia cells.

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  • (PMID = 17889932.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Blocking; 0 / Antigens, Plant; 0 / Immunoglobulin G; 0 / Plant Proteins; 0 / Protein Isoforms; 126161-14-6 / Bet v 1 allergen, Betula; 37341-29-0 / Immunoglobulin E
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63. Teshima R, Amano F, Nakamura R, Tanaka Y, Sawada J: Effects of polyunsaturated fatty acids on calcium response and degranulation from RBL-2H3 cells. Int Immunopharmacol; 2007 Feb;7(2):205-10
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  • To investigate the biological activity of various polyunsaturated fatty acids (PUFAs) on the allergic reaction, we examined the effects of six PUFAs and two saturated fatty acids on calcium response and degranulation from rat basophilic leukemia (RBL-2H3) cells.

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  • (PMID = 17178388.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Fatty Acids, Unsaturated; 85166-31-0 / Inositol 1,4,5-Trisphosphate; SY7Q814VUP / Calcium
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64. Buku A, Condie BA, Price JA, Mezei M: [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors. J Pept Res; 2005 Sep;66(3):132-7
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  • In contrast to MCD peptide, [Ala12]MCD showed a 50% inhibition of IgE binding to the Fc epsilon RI alpha mast cell receptor by using rat basophilic leukemia (RBL-2H3) mast cells and fluorescence polarization.

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  • (PMID = 16083440.001).
  • [ISSN] 1397-002X
  • [Journal-full-title] The journal of peptide research : official journal of the American Peptide Society
  • [ISO-abbreviation] J. Pept. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Peptides; 0 / Receptors, Cell Surface; 32908-73-9 / mast cell degranulating peptide; 37341-29-0 / Immunoglobulin E; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; OF5P57N2ZX / Alanine
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65. Avril T, Freeman SD, Attrill H, Clarke RG, Crocker PR: Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem; 2005 May 20;280(20):19843-51
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  • To investigate the role of these motifs in Siglec-5-dependent signaling, we used transfected rat basophil leukemia cells as a model system.

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  • (PMID = 15769739.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Intracellular Signaling Peptides and Proteins; 0 / Lectins; 0 / Recombinant Fusion Proteins; 0 / SIGLEC5 protein, human; 42HK56048U / Tyrosine; 9007-49-2 / DNA; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / PTPN6 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Ptpn11 protein, rat; EC 3.1.3.48 / Ptpn6 protein, rat
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71. Torres AJ, Vasudevan L, Holowka D, Baird BA: Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays. Proc Natl Acad Sci U S A; 2008 Nov 11;105(45):17238-44
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  • Patterned surfaces that present specific ligands in spatially defined arrays are used to examine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.
  • Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the patterned regions occupied by the ligands and associates preferentially with exposed regions of the silicon substrate.

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  • (PMID = 19004813.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI018306; United States / NIAID NIH HHS / AI / AI18306
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Ligands; 0 / Paxillin; 0 / RNA, Small Interfering; 0 / Receptors, IgE; 0 / Talin; 125361-02-6 / Vinculin; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2582307
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72. Hochwallner H, Schulmeister U, Swoboda I, Balic N, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, van Tol EA, Valenta R, Spitzauer S: Microarray and allergenic activity assessment of milk allergens. Clin Exp Allergy; 2010 Dec;40(12):1809-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The allergenic activity of the individual allergens was tested using patients' sera for loading rat basophil leukaemia cells (RBL) expressing the α-chain of the human receptor FcεRI.

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20860558.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, CD; 0 / Fc(alpha) receptor; 0 / Milk Proteins; 0 / Receptors, Fc; 37341-29-0 / Immunoglobulin E
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73. Chandrasekaran CV, Gupta A, Agarwal A: Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol; 2010 May 27;129(2):203-7
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  • MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20307638.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Plant Extracts; 1HGW4DR56D / Leukotriene B4; 37H9VM9WZL / Calcimycin
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74. Motojima H, Yamada P, Han J, Ozaki M, Shigemori H, Isoda H: Properties of fulvic acid extracted from excess sludge and its inhibiting effect on beta-hexosaminidase release. Biosci Biotechnol Biochem; 2009 Oct;73(10):2210-6

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  • The biological properties of fulvic acid from excess sludge and solubilized excess sludge showed an inhibitory effect on beta-hexosaminidase release at the antigen-antibody binding stage and antigen-receptor binding stage by using rat basophilic leukemia cells.

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  • (PMID = 19809201.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies; 0 / Benzopyrans; 0 / Sewage; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; XII14C5FXV / fulvic acid
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75. Borges JP, Culerrier R, Aldon D, Barre A, Benoist H, Saurel O, Milon A, Didier A, Rougé P: GATEWAY technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3). Protein Expr Purif; 2010 Apr;70(2):277-82

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  • The reactivity of rMal d 3 towards IgE from apple allergic patients and in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits.

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  • [Copyright] (c) 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19778615.001).
  • [ISSN] 1096-0279
  • [Journal-full-title] Protein expression and purification
  • [ISO-abbreviation] Protein Expr. Purif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Plant; 0 / Carrier Proteins; 0 / Mal d 3 allergen; 0 / Recombinant Proteins; 0 / lipid transfer protein
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76. Alvarez-Errico D, Sayós J, López-Botet M: The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. J Immunol; 2007 Jan 15;178(2):808-16
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  • In the present study, immunoprecipitation analysis revealed that both the p85alpha subunit of PI3K and Src homology region 2 domain-containing phosphatase-1 could be recruited by IREM-1 in transfected cells as well as in the U937 monocytic leukemia cells, which constitutively express the receptor.
  • By assaying the ability of different IREM-1 mutants to regulate the secretion of beta-hexosaminidase induced via FcRepsilonI in rat basophilic leukemia cells, both Y205 and Y249 appeared crucial for IREM-1-mediated inhibition.
  • Remarkably, engagement of an IREM-1 mutant (Y(205,249,284)F), which did not recruit Src homology region 2 domain-containing phosphatase-1 and lost its inhibitory function, induced rat basophilic leukemia cell degranulation.

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  • (PMID = 17202342.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / CD300C protein, human; 0 / GRB2 Adaptor Protein; 0 / Membrane Glycoproteins; 0 / Protein Subunits; 0 / Receptors, IgE; 42HK56048U / Tyrosine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.16 / Protein Phosphatase 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6
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77. Edel JB, Wu M, Baird B, Craighead HG: High spatial resolution observation of single-molecule dynamics in living cell membranes. Biophys J; 2005 Jun;88(6):L43-5
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  • In this letter we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled cell membrane component on a surface containing zero-mode waveguides (ZMWs).

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  • (PMID = 15821167.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbocyanines; 0 / Fluorescent Dyes; 40957-95-7 / 3,3'-dioctadecylindocarbocyanine
  • [Other-IDs] NLM/ PMC1305672
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78. Yanase Y, Hiragun T, Kaneko S, Gould HJ, Greaves MW, Hide M: Detection of refractive index changes in individual living cells by means of surface plasmon resonance imaging. Biosens Bioelectron; 2010 Oct 15;26(2):674-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The SPRI sensor could detect reactions of individual rat basophilic leukemia (RBL-2H3) cells, mouse keratinocyte (PAM212) cells, and human epidermal carcinoma (A431) cells in response to either specific or non-specific stimuli, such as antigen, phorbol ester or epidermal growth factor, with or without their inhibitors, resembling signals obtained by a conventional SPR sensor.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20673712.001).
  • [ISSN] 1873-4235
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0501494
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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79. Ferreres F, Pereira DM, Gil-Izquierdo A, Valentão P, Botelho J, Mouga T, Andrade PB: HPLC-PAD-atmospheric pressure chemical ionization-MS metabolite profiling of cytotoxic carotenoids from the echinoderm Marthasterias glacialis (spiny sea-star). J Sep Sci; 2010 Aug;33(15):2250-7
The Lens. Cited by Patents in .

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  • The purified carotenoid fraction displayed a strong cell proliferation inhibition against rat basophilic leukemia RBL-2H3 (IC(25)=268 microg/mL) cancer cell line.

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  • (PMID = 20574958.001).
  • [ISSN] 1615-9314
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 36-88-4 / Carotenoids
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80. Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T: Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol; 2010 Jul;10(7):769-76
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  • We examined the effects of Lico A and related chalcones on degranulation in a rat basophilic leukemia cell line, RBL-2H3.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399908.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Chalcones; 42HK56048U / Tyrosine; 58749-22-7 / licochalcone A; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SY7Q814VUP / Calcium
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81. Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H: Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Planta Med; 2010 Oct;76(14):1512-8
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

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  • Wight on the basophilic cell-mediated allergic reaction.
  • The effect of acteoside on β-hexosaminidase release and intracellular [Ca (2+)] I level from rat basophilic leukemia (RBL-2H3) cells was determined.
  • Also, ELISA was used to determine the level of histamine, tumor necrosis factor (TNF)- α, and interleukin (IL)-4 on human basophilic (KU812) cells.
  • The effect of acteoside on basophilic cell viability was determined using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay.
  • Our findings provide evidence that acteoside inhibits basophilic cell-derived immediate-type and delayed-type allergic reactions.
  • This is the first report describing antiallergic activity of acteoside extracted from CISTANCHE TUBULOSA on basophilic cells.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20354949.001).
  • [ISSN] 1439-0221
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Catechols; 0 / Glucosides; 0 / Glycosides; 0 / IL4 protein, human; 0 / Phenols; 0 / Tumor Necrosis Factor-alpha; 0 / cistanoside A; 207137-56-2 / Interleukin-4; 37H9VM9WZL / Calcimycin; 61276-17-3 / acteoside; 820484N8I3 / Histamine; 82854-37-3 / echinacoside; EC 3.2.1.52 / beta-N-Acetylhexosaminidases; NI40JAQ945 / Tetradecanoylphorbol Acetate; SY7Q814VUP / Calcium
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82. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y: Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol; 2010 Sep;32(3):454-61
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  • To investigate the antiallergic effects of fermented grape marc from Negroamaro (N-FGM), we examined antigen (Ag)-induced degranulation of rat basophilic leukemia (RBL-2H3) cells.
  • [MeSH-minor] Animals. Antigens / immunology. Basophil Degranulation Test. Fermentation. Immunoglobulin E / immunology. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein-Tyrosine Kinases / metabolism. Rats. Syk Kinase. Tumor Cells, Cultured

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  • (PMID = 20100066.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D008123/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Antigens; 0 / Intracellular Signaling Peptides and Proteins; 37341-29-0 / Immunoglobulin E; 9IKM0I5T1E / Quercetin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Syk Kinase; EC 2.7.10.2 / Syk protein, rat
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83. Gadermaier G, Jahn-Schmid B, Vogel L, Egger M, Himly M, Briza P, Ebner C, Vieths S, Bohle B, Ferreira F: Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol; 2010 Mar;47(6):1292-8
The Lens. Cited by Patents in .

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  • Mediator release assays using rat basophil leukemia cells showed that these variants displayed a 1x10(5)-fold reduced allergenic potency as compared to wild-type protein.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20022115.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 20011
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies; 0 / Antigens, Plant; 0 / Art v 1 protein, mugwort; 0 / Mutant Proteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E; K848JZ4886 / Cysteine
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84. Schulmeister U, Hochwallner H, Swoboda I, Focke-Tejkl M, Geller B, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Keller W, Niggemann B, Quirce S, Ebner C, Mari A, Pauli G, Herz U, Valenta R, Spitzauer S: Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen. J Immunol; 2009 Jun 1;182(11):7019-29
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  • The allergenic activity of ralphaS1-casein and the alphaS1-casein-derived peptides was determined using rat basophil leukemia cells transfected with human FcepsilonRI, which had been loaded with the patients' serum IgE.
  • Our results demonstrate that ralphaS1-casein as well as alphaS1-casein-derived peptides exhibit IgE reactivity, but mainly the intact ralphaS1-casein induced strong basophil degranulation.

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  • (PMID = 19454699.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Caseins; 0 / DNA, Complementary; 0 / Epitopes; 0 / Peptide Fragments; 0 / Receptors, IgE; 37341-29-0 / Immunoglobulin E
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85. Lim H, Son KH, Bae KH, Hung TM, Kim YS, Kim HP: 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. Phytother Res; 2009 Oct;23(10):1489-92
Hazardous Substances Data Bank. NITRIC OXIDE .

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  • The compounds including schizandrins, schisandrols, gomisins, fargesin, eudesmin and lirioresinol B dimethyl ether, inhibited 5-LOX-catalysed leukotriene production from A23187-treated rat basophilic leukemia (RBL-1) cells at concentrations of 1-100 microm.

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  • [Copyright] (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19277963.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Cyclooctanes; 0 / Leukotrienes; 0 / Lignans; 0 / Lipoxygenase Inhibitors; 0 / Plant Extracts; 0 / schisandrol A; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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86. Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C: A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem; 2009 Mar 27;284(13):8421-6
The Lens. Cited by Patents in .

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  • Expressing OASF in rat basophilic leukemia (RBL) mast cells demonstrated its enhanced plasma membrane targeting associated with 2.5-fold larger CRAC currents in comparison with the complete STIM1 C terminus.

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  • (PMID = 19189966.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ P18169/ P18280/ P21118
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / ORAI1 protein, human; 0 / Orai1 protein, rat; 0 / STIM1 protein, human; 0 / Stim1 protein, rat; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2659200
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87. Jensen BM, Swindle EJ, Iwaki S, Gilfillan AM: Generation, isolation, and maintenance of rodent mast cells and mast cell lines. Curr Protoc Immunol; 2006 Sep;Chapter 3:Unit 3.23
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  • In addition to human mast cells, the major cell culture systems employed to investigate these responses are rat and mouse peritoneal mast cells, mouse bone-marrow-derived mast cells, the rat basophilic leukemia cell line RBL-2H3, and the mouse MC/9 mast cell line.

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  • (PMID = 18432974.001).
  • [ISSN] 1934-368X
  • [Journal-full-title] Current protocols in immunology
  • [ISO-abbreviation] Curr Protoc Immunol
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / ZIA AI000965-04; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
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88. Leung WH, Bolland S: The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol; 2007 Jul 1;179(1):95-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 interacts with the FcepsilonRI beta-chain, Gab2 and Lyn and that unlike SHIP-1, it does not associate with SHC in mast cells.


89. Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD: Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. J Pharmacol Exp Ther; 2007 Jul;322(1):332-40
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  • Using rat basophilic leukemia 2H3 cell line (RBL-2H3), we previously established that activation of A(3) adenosine receptors (A(3)AR) stimulates SERT activity via both PKG and p38 MAPK (Zhu et al., 2004a).

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  • (PMID = 17460150.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA07390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Adenosine A3; 0 / Serotonin Plasma Membrane Transport Proteins; 152918-18-8 / N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; 20125-40-0 / N-(1-methyl-2-phenylethyl)adenosine; 333DO1RDJY / Serotonin; 35920-39-9 / Adenosine-5'-(N-ethylcarboxamide); EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; K72T3FS567 / Adenosine
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90. Lessmann E, Leitges M, Huber M: A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol; 2006 May;18(5):767-73
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  • A critical role of PKC-epsilon in antigen-triggered activation of various signaling pathways was observed in basophilic leukemia cells.


91. Rettig JR, Folch A: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem; 2005 Sep 1;77(17):5628-34
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  • We have characterized microwell occupancy by cells for a range of microwell dimensions and seeding parameters and optimized it for fibroblasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cell).

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  • (PMID = 16131075.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R21DC006465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Chen BH, Wu PY, Chen KM, Fu TF, Wang HM, Chen CY: Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod; 2009 May 22;72(5):950-3
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  • In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically.

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  • (PMID = 19271742.001).
  • [ISSN] 1520-6025
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Phenols
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93. Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Koshimizu S, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y: Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. J Agric Food Chem; 2010 Jun 23;58(12):7149-57
MedlinePlus Health Information. consumer health - Allergy.

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  • [Title] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
  • [MeSH-minor] Animals. Basophil Degranulation Test. Cell Degranulation / drug effects. Cell Line, Tumor. Disease Models, Animal. Histamine Release / drug effects. Humans. Male. Mice. Mice, Inbred ICR. Quercus / chemistry. Quercus / immunology. Rats. Skin / immunology

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  • (PMID = 20507065.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts; 37341-29-0 / Immunoglobulin E
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94. Ayuso R, Grishina G, Ibáñez MD, Blanco C, Carrillo T, Bencharitiwong R, Sánchez S, Nowak-Wegrzyn A, Sampson HA: Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. J Allergy Clin Immunol; 2009 Jul;124(1):114-20
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  • BACKGROUND: Shellfish allergy is a long-lasting disorder usually persisting throughout life.
  • A functional assay with a rat basophilic leukemia cell line was used to determine the capacity for mediator release induced by SCP.

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  • (PMID = 19523674.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 05931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Calcium-Binding Proteins; 0 / Recombinant Proteins; 37341-29-0 / Immunoglobulin E; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases
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95. Curtis T, Naal RM, Batt C, Tabb J, Holowka D: Development of a mast cell-based biosensor. Biosens Bioelectron; 2008 Feb 28;23(7):1024-31
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  • Rat basophilic leukemia (RBL) mast cells offer excellent potential for biosensor applications because they are robust and undergo a dramatic exocytotic response within minutes of antigen addition.

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  • (PMID = 18055192.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI022449-13; United States / NIAID NIH HHS / AI / R01 AI022449; United States / NIAID NIH HHS / AI / AI 22449; United States / NIAID NIH HHS / AI / R01 AI022449-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS40874; NLM/ PMC2269709
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96. Chen HH, Purtteman JJ, Heimfeld S, Folch A, Gao D: Development of a microfluidic device for determination of cell osmotic behavior and membrane transport properties. Cryobiology; 2007 Dec;55(3):200-9
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  • During experiments, rat basophilic leukemia (RBL-1 line) cells were injected into the inlet of the device, allowed to flow downstream, and were trapped within a perfusion chamber.

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  • (PMID = 17889847.001).
  • [ISSN] 1090-2392
  • [Journal-full-title] Cryobiology
  • [ISO-abbreviation] Cryobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dimethylpolysiloxanes; 0 / Silicones; 059QF0KO0R / Water; 63148-62-9 / baysilon
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97. Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, Wang MW: The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol; 2006 Nov 15;177(10):7050-8
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  • More recent studies have shown that CsA also inhibits fMLF-induced degranulation in differentiated HL-60 promyelocytic leukemia cells.
  • In this study we used human neutrophils, differentiated HL-60 cells, and rat basophilic leukemia (RBL)-2H3 cells expressing human FPR (RBL-FPR) to identify the action site of CsA.


98. Brown SL, Jala VR, Raghuwanshi SK, Nasser MW, Haribabu B, Richardson RM: Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. J Immunol; 2006 Sep 1;177(5):3242-9
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  • Rat basophilic leukemia cell line (RBL-2H3) stably expressing wild-type PAFR, PAFR-G alpha(i3), or PAFR-G alpha(q) was generated and characterized.

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  • (PMID = 16920964.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-38910; United States / NIAID NIH HHS / AI / AI-52381
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Activating Factor; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Interleukin-8A; 0 / platelet activating factor receptor; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; SY7Q814VUP / Calcium
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99. Parusel I, Kahl S, Braasch F, Glowacki G, Halverson GR, Reid ME, Schawalder A, Ortolan E, Funaro A, Malavasi F, Hardie D, Halder S, Buckley CD, Haag F, Koch-Nolte F: A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cell Immunol; 2005 Jul-Aug;236(1-2):59-65
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  • The mAbs reacted weakly also with human umbilical vein endothelial cells and the basophilic leukemia KU-812.

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  • (PMID = 16168396.001).
  • [ISSN] 0008-8749
  • [Journal-full-title] Cellular immunology
  • [ISO-abbreviation] Cell. Immunol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL54459
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cell Cycle Proteins; 0 / GML protein, human; 0 / GPI-Linked Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / ART4 protein, human
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100. Linhart B, Hartl A, Jahn-Schmid B, Verdino P, Keller W, Krauth MT, Valent P, Horak F, Wiedermann U, Thalhamer J, Ebner C, Kraft D, Valenta R: A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol; 2005 May;115(5):1010-6
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  • Immune responses to the hybrid molecule were studied in BALB/c mice and rat basophil leukemia assays.
  • IgG antibodies induced by vaccination with the hybrid blocked immediate allergic reactions, as demonstrated by rat basophil degranulation assays in a murine model of grass pollen allergy.

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  • (PMID = 15867859.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Epitopes, B-Lymphocyte; 0 / Immunoglobulin G; 0 / Recombinant Fusion Proteins; 0 / Vaccines; 0 / Vaccines, DNA
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