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11. Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW, Werning JW, Villaret DB: Definitive radiotherapy for squamous cell carcinoma of the base of tongue. Am J Clin Oncol; 2006 Feb;29(1):32-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive radiotherapy for squamous cell carcinoma of the base of tongue.
  • OBJECTIVE: To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer.
  • METHODS: There were 333 patients with squamous cell carcinoma of the base of tongue treated with definitive RT and had follow-up from 0.2 to 26.2 years.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Retrospective Studies. Treatment Outcome

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  • (PMID = 16462500.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Munck K, Ali MJ, Murr AH, Goldberg AN: Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma. Laryngoscope; 2005 Jul;115(7):1283-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma.
  • OBJECTIVE: To examine the impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring cancers by comparing the experience of a public hospital and an academic tertiary care medical center.
  • Patients included in the study had a histologic diagnosis of Waldeyer's ring carcinoma, primary treatment with radiation, and no prior treatment of Waldeyer's ring carcinoma.
  • MAIN OUTCOME MEASURES: The time of diagnosis to start of radiation therapy, dose of radiation, number of treatment days, duration of treatment, and 1 and 3 year survival were recorded.
  • RESULTS: The time course from diagnosis of nasopharyngeal carcinoma to start of radiation therapy was 56 days at SFGH compared with 34 days at UCSFMC.
  • Difference in diagnosis to treatment intervals for base of tongue cancer was also significant at 66 days at SFGH compared with 31 days at UCSFMC (P = .0038).
  • For cancer of the tonsil, the diagnosis to treatment interval was 70 days at SFGH versus 40 days at UCSFMC (P = .0005).
  • [MeSH-major] Carcinoma / pathology. Carcinoma / radiotherapy. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / pathology. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Academic Medical Centers. Biopsy. California. Follow-Up Studies. Hospitals, Public. Humans. Neoplasm Staging. Radiotherapy / statistics & numerical data. Retrospective Studies. Socioeconomic Factors. Survival Rate. Time Factors

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  • (PMID = 15995522.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X: MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett; 2010 Sep 24;584(18):4115-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
  • Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear.

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  • [Copyright] Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 20816961.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NCI NIH HHS / CA / R01 CA139596-03; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / CA139596-03; United States / NIDCR NIH HHS / DE / K22 DE014847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Dnd1 protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / MIRN24 microRNA, human; 0 / MicroRNAs; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ NIHMS234020; NLM/ PMC2964934
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4. Han P, Hu K, Frank DK, Sessions RB, Harrison LB: Management of cancer of the base of tongue. Otolaryngol Clin North Am; 2005 Feb;38(1):75-85, viii
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  • [Title] Management of cancer of the base of tongue.
  • The management of base of tongue cancer has evolved steadily over time.
  • This article reports the results of a literature review of base of tongue cancer emphasizing a multidisciplinary approach to obtain optimal results in terms of cure and quality of life.
  • [MeSH-major] Tongue Neoplasms / pathology. Tongue Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Glossectomy. Humans. Neoplasm Staging. Quality of Life. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 15649500.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 31
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15. Yoshimoto S, Kawabata K, Mitani H, Yonekawa H, Beppu T, Fukushima H, Sasaki T: Treatment results for 84 patients with base of tongue cancer. Acta Otolaryngol Suppl; 2007 Dec;(559):123-8
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  • [Title] Treatment results for 84 patients with base of tongue cancer.
  • OBJECTIVES: Because tumors originating from the base of the tongue are rare, few large-scale studies of such tumors have been performed.
  • PATIENTS AND METHODS: From 1971 to 2000, 84 patients with previously untreated and resectable squamous cell carcinoma of the base of the tongue were treated at the Head and Neck Department of the Cancer Institute Hospital, Tokyo.
  • [MeSH-major] Carcinoma, Squamous Cell. Tongue Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Hypopharyngeal Neoplasms / secondary. Laryngectomy. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Preoperative Care

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  • (PMID = 18340583.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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41. Mackle T, O'Dwyer T: A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review. J Laryngol Otol; 2006 May;120(5):393-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review.
  • INTRODUCTION: The study sought to compare and contrast squamous cell carcinoma (SCC) of the anterior mobile tongue with SCC of the tongue base, with emphasis on clinical presentation, management and outcome.
  • METHODS: This was a retrospective, comparative analysis of patients treated for SCC of the tongue over a 10-year period.
  • Cox's regression model was used to assess the effect of tumour site on survival.
  • RESULTS: The study included 142 patients, of whom 86 were treated for SCC of the anterior tongue and 56 for tongue base lesions.
  • Patients with carcinoma of the anterior tongue tended to present with a visible lump or ulceration of the tongue, whereas the majority of patients with tongue base SCC presented with pain.
  • Sixty per cent of anterior tongue lesions were early stage (I or II) at initial presentation as compared with 21 per cent of tongue base lesions.
  • CONCLUSION: Patients with anterior tongue lesions had a better prognosis, but this was not statistically significant when adjusted for stage.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Regression Analysis. Retrospective Studies. Sex Distribution. Survival Rate

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  • (PMID = 16563198.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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42. Pabiszczak M, Wierzbicka M, Szyfter W: [Localisation and direction of spread in oral and oropharyngeal cancer in the material of Head and Neck Oncological Surgery Department, University of Medical Sciences in Poznań]. Otolaryngol Pol; 2005;59(2):201-7
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  • The directions of tumor spread are determined by the anatomy of the affected organ.
  • The vessel, nerve anatomy and presence of structures, that may potentially constitute a barrier for spread out of the tumor are of crucial importance.
  • The examination was conducted on the base of retrospective analysis of ambulatory charts and the hospital files.
  • The primary localization included in the palatine tonsil (82 patients), trunk of the tongue (48 patients) and floor of the mouth (20 patients) were predominated.
  • The spread directions included: floor of the mouth (36) soft palate (35), base of tongue (33), hypopharynx (20) and trunk of tongue (16).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Poland. Retrospective Studies

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  • (PMID = 16095088.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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43. Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A: Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys; 2009 Aug 1;74(5):1365-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND MATERIALS: Between August 2003 and June 2007, 20 patients who presented with squamous cell carcinoma of the tonsil, without involvement of the base of the tongue or midline soft palate, and with Stage N1-N2b disease were prospectively treated with radiotherapy to the primary site and ipsilateral neck.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / radiotherapy. Male. Middle Aged. Neck. Neoplasm Staging. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Survival Rate. Treatment Outcome

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  • (PMID = 19168295.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Grant DG, Hinni ML, Salassa JR, Perry WC, Hayden RE, Casler JD: Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1225-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The primary tumor sites were the tonsil (n = 28 [41%]), tongue base (n = 28 [41%]), pharyngeal wall (n = 8 [12%]), soft palate (n = 4 [6%]), and vallecula (n = 1 [1%]).
  • [MeSH-minor] Enteral Nutrition. Female. Humans. Laryngeal Neoplasms. Length of Stay. Male. Neck Dissection. Neoplasm Recurrence, Local. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Tracheostomy

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  • (PMID = 20026820.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Walid MS: Lymphoma of the base of the tongue: an incidental finding on the preoperative workup for a spine surgery. J Clin Med Res; 2009 Aug;1(3):184-5
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  • [Title] Lymphoma of the base of the tongue: an incidental finding on the preoperative workup for a spine surgery.
  • Lymphoma of the tongue is very rare and accounts for 1% of all malignant tumors of the oral cavity.
  • During the preoperative workup for cervical spine surgery a tumor at the base of the tongue was discovered which was confirmed by pathology to be a lymphoma.
  • KEYWORDS: Lymphoma; Tongue; Spine surgery; Preoperative workup.

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  • (PMID = 22493655.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3318884
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70. Perkins JA, Inglis AF, Sie KC, Manning SC: Recurrent thyroglossal duct cysts: a 23-year experience and a new method for management. Ann Otol Rhinol Laryngol; 2006 Nov;115(11):850-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Successful procedures used for secondary TGDC management included central neck dissection with directed base of tongue (BOT) excision in 6 of 9 patients (67%), secondary Sistrunk operation with limited BOT resection in 12 of 27 patients (44%), revision Sistrunk operation with BOT dissection in 7 of 11 patients (64%), and suture-guided transhyoid pharyngotomy in 8 of 8 patients (100%).
  • The factors associated with TGDC recurrence were inaccurate initial diagnosis (17 of 34 or 50%), infection (5 of 34 or 15%), unusual TGDC presentation (5 of 34 or 15%), and lack of BOT musculature removal (7 of 34 or 20%).
  • [MeSH-major] Neck Dissection / methods. Neoplasm Recurrence, Local / surgery. Pharynx / surgery. Thyroglossal Cyst / surgery

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  • (PMID = 17165669.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Gupta R, Gupta K, Gupta R: Polymorphous low-grade adenocarcinoma of the tongue: a case report. J Med Case Rep; 2009;3:9313
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  • [Title] Polymorphous low-grade adenocarcinoma of the tongue: a case report.
  • INTRODUCTION: Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions.
  • In rare cases, the mass can also occur in the tongue.
  • We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.
  • CASE PRESENTATION: A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa.
  • Its occurrence in the tongue is rare with very few cases reported in the literature.
  • It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.

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  • (PMID = 20062742.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803836
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72. Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A: Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jun;109(6):e67-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically, the tumor shows cystic degeneration of the neoplastic epithelium, producing a prominent alveolar pattern and pseudoglandular structures with acantholytic cells.
  • This case concerns a 72-year-old woman who presented with the chief complaint of burning tongue and soreness of the lips.
  • Clinical examination revealed an ulcerated and elevated mass on the edentulous left maxillary ridge, beneath the base of a partial denture.
  • An incisional biopsy rendered the diagnosis of adenoid squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20451835.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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73. Díaz Molina JP, Rodrigo JP, Llorente JL, Alvarez Marcos C, Moreno C, Suárez C: [Oncologic and functional results of surgical treatment for base of tongue carcinomas]. Acta Otorrinolaringol Esp; 2010 Sep-Oct;61(5):351-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Oncologic and functional results of surgical treatment for base of tongue carcinomas].
  • [Transliterated title] Resultados oncológicos y funcionales del tratamiento quirúrgico de los carcinomas de base de lengua.
  • INTRODUCTION AND OBJECTIVES: Squamous cell carcinomas at the base of the tongue are usually diagnosed at advanced stages, and their optimal treatment has not been established.
  • The aim of this study was to describe the functional and oncological outcomes of patients with base of tongue carcinomas treated with surgery.
  • MATERIALS AND METHODS: A retrospective study on 132 patients with base of tongue carcinoma surgically treated in our hospital between 1990 and 2007 was carried out.
  • CONCLUSIONS: The prognosis of squamous cell carcinomas of the base of the tongue is poor, especially in advanced stages.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Recovery of Function. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier España, S.L. All rights reserved.
  • (PMID = 20684822.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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74. Lam L, Logan RM, Luke C, Rees GL: Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004. Oral Oncol; 2007 Feb;43(2):150-8
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  • [Title] Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004.
  • This is a retrospective study of patients with oral and oropharyngeal tongue cancers who presented to the Royal Adelaide Hospital (RAH) from 1987 to 2004.
  • The aims of this study were to determine sociodemographic and tumour characteristics, treatment patterns and five-year disease-specific survival of the disease.
  • All cases of tongue cancers, including untreated and palliative cases, were identified through the Royal Adelaide Hospital Cancer Registry and were included in statistical analysis.
  • A total of 212 cases of tongue cancer were identified.
  • Almost 30% of recorded cases were oropharyngeal or base of tongue cancers.
  • Nearly half of the patients had advanced stage (III and IV) disease at presentation, which was significantly associated with rural area of residence, base of tongue sub-site and early diagnostic period.
  • Palliative treatment was more likely to be given to patient with oropharyngeal tongue cancers or advance stage disease.
  • Poorer survival was significantly associated with age 45 years or older, oropharyngeal tongue cancers and advanced stage disease.
  • Tongue cancer is an important health issue associated with poor survival.
  • Early detection and diagnosis is important in order to improve survival rate for this malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Oropharyngeal Neoplasms / therapy. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Epidemiologic Methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palliative Care / utilization. Prognosis. Treatment Outcome

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  • (PMID = 16807069.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, Hartig GK: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope; 2008 Aug;118(8):1377-82
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  • [Title] Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy.
  • OBJECTIVES/HYPOTHESIS: Tumor volume has been demonstrated to play a prognostic role in many head and neck cancers.
  • The purpose of this study was to conduct an institutional review analyzing the correlation between tumor volume and locoregional control of oropharyngeal squamous cell cancer treated with primary radiotherapy.
  • METHODS: Seventy-nine patients from 1991 to 2005 with primary T1 to T4 oropharyngeal squamous cell carcinoma (base of tongue, n = 31; soft palate, n = 1; tonsils, n = 47) were treated with primary radiotherapy.
  • Tumor volumes were measured from pretreatment computerized tomography scans by two observers.
  • Three-dimensional tumor volumes were calculated using a computer digitizer for each computed tomography slice showing the primary lesion.
  • Survival analysis, using the methods of Kaplan and Meier, was performed to assess whether tumor volume, Tumor, Node, Metastasis classification, tumor stage, or location were associated with locoregional failure.
  • RESULTS: Tumor volume did not significantly correlate with locoregional failure (observer 1, P = .6244; observer 2, P = .5612).
  • Nodal status, tumor stage, and location did not significantly correlate with locoregional failure rate.
  • CONCLUSIONS: Tumor volume does not appear to play a significant role in predicting locoregional recurrence for patients with primary squamous cell cancer of the oropharynx treated with primary radiotherapy.
  • [MeSH-minor] Female. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Observer Variation. Prognosis. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18418275.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Zacharia TT, Som PM: Multiple adult rhabdomyomas of the oropharynx, base of the tongue, and floor of the mouth: magnetic resonance findings. Arch Otolaryngol Head Neck Surg; 2008 Aug;134(8):892-4
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  • [Title] Multiple adult rhabdomyomas of the oropharynx, base of the tongue, and floor of the mouth: magnetic resonance findings.
  • [MeSH-major] Magnetic Resonance Imaging. Mouth Floor. Mouth Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Oropharyngeal Neoplasms / diagnosis. Rhabdomyosarcoma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Humans. Male. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18711066.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Chennupati SK, Norris R, Dunham B, Kazahaya K: Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol; 2008 Jan;72(1):115-9
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  • [Title] Osteosarcoma of the skull base: case report and review of literature.
  • Osteosarcomas are an aggressive neoplasm composed of spindle cells producing osteoid.
  • A case report presentation of a skull base osteosarcoma in a teenage female.
  • There were also findings consistent with chronic denervation of her right tongue and pharynx.
  • Repeat imaging revealed progression of the skull base lesion with extension into the right sphenoid sinus.
  • The diagnosis of high-grade osteosarcoma was made by histologic morphology and immunohistochemistry.
  • Osteosarcoma of the skull base is a rare entity.
  • [MeSH-major] Osteosarcoma / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 17980919.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 9
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78. Milano MT, Vokes EE, Kao J, Jackson W, List MA, Stenson KM, Witt ME, Dekker A, MacCracken E, Garofalo MC, Chmura SJ, Weichselbaum RR, Haraf DJ: Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol; 2006 May;28(5):1141-51
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  • Sixty-nine patients with Stage IV head and neck cancer (and stage III base of tongue and hypopharynx) enrolled in a Phase II study of definitive chemoradiation; 20 received all or part of their radiation with IMRT.
  • [MeSH-minor] Adult. Aged. Biopsy. Carboplatin / administration & dosage. Humans. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Radiotherapy / adverse effects. Radiotherapy Dosage. Survival Analysis

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  • (PMID = 16596230.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA14599; United States / NIDCR NIH HHS / DE / P50 DE11921-04
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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79. Hancock SB, Krempl GA, Canfield V, Bogardus C, Kojouri K, Kaneaster SK, Medina JE: Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. Laryngoscope; 2008 Aug;118(8):1357-61
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  • [Title] Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy.
  • OBJECTIVES/HYPOTHESIS: To assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage III and IV base of tongue cancer.
  • STUDY DESIGN: Subgroup analysis of patients with base of tongue cancer enrolled in a single-institution prospective phase II trial, evaluating an organ-preservation approach in the treatment of locally advanced head and neck cancer.
  • If the primary tumor exhibited a complete or partial response, patients were treated with radiation and weekly taxol and carboplatin for 7 weeks.
  • CONCLUSIONS: The treatment regimen studied is remarkably effective in stage III and IV base of tongue cancer with 100% of patients completing the protocol alive to date.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Disease-Free Survival. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Nervous System Diseases / chemically induced. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 18528311.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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80. Weinstein GS, Quon H, O'Malley BW Jr, Kim GG, Cohen MA: Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial. Laryngoscope; 2010 Sep;120(9):1749-55
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  • There were 29 males and two females, with ages ranging from 36 to 76 years (median = 55 years) with one palate, one lateral wall, 17 tonsil, 11 base of tongue, and one vallecula primary tumor classified as follows: T1 (n = 9, 29%), T2 (n = 15, 48.4%), T3 (n = 7, 22.6%), N0 (n = 6, 19.4%), N1 (n = 15, 48.4%), N2b (n = 10, 32.3%), and N2c (n = 1, 3.2%).
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant

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  • (PMID = 20717944.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Tincani AJ, Altemani A, Martins AS, Barreto G, Valério JB, Del Negro A, Araújo PP: Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location. Ear Nose Throat J; 2005 Dec;84(12):794-5, 799
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  • [Title] Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate.
  • We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck.
  • The tumor was resected through the oral cavity with wide margins and dissection.
  • [MeSH-major] Adenocarcinoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16408562.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Hans S, Chauvet D, Sadoughi B, Brasnu DF: Cardiac metastasis after squamous cell carcinoma of the base of tongue. Am J Otolaryngol; 2009 May-Jun;30(3):206-8
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  • [Title] Cardiac metastasis after squamous cell carcinoma of the base of tongue.
  • We report a case of squamous cell carcinoma of the base of tongue secondarily complicated with cardiac metastasis 6 months after surgical treatment resulted in successful local control.
  • CONCLUSIONS: Cardiac metastasis should be suspected when new cardiovascular symptoms are observed in patients with a history of head and neck neoplasm.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Heart Neoplasms / secondary. Tongue Neoplasms / pathology

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  • (PMID = 19410127.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Silva P, Slevin NJ, Sloan P, Valentine H, Cresswell J, Ryder D, Price P, Homer JJ, West CM: Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1551-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer.
  • Currently most management decisions are based on clinical parameters with little appreciation of patient differences in underlying tumor biology.
  • We investigated the prognostic significance of clinicopathologic features and tumor hypoxia-inducible factor-1alpha (HIF-1alpha) expression in a homogeneous series of patients who underwent radiotherapy.
  • METHODS AND MATERIALS: An audit identified 133 consecutive patients with histologically proven squamous cell carcinoma of the tonsil or tongue base.
  • Tumor HIF-1alpha expression was examined in 79 patients.
  • 3.04-176.7) than the tongue-base tumor (HR, 2.86; 95% CI, 1.14-7.19) group (p = 0.03, test for interaction).
  • High tumor HIF-1alpha expression was associated with low blood Hb levels (p = 0.03).
  • The work highlights the importance of studying homogeneous groups of patients in HNSCC, and the complex interrelationships between tumor biology and clinicopathologic factors.
  • The establishment of tumor-type specific markers would represent a major advance in this area.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / radiotherapy. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / radiotherapy. Hemoglobins / metabolism. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Tongue Neoplasms / genetics. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / genetics. Tonsillar Neoplasms / radiotherapy. Treatment Outcome. Young Adult

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  • (PMID = 19028277.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hemoglobins; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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84. Xie J, Dong P, Jin B, Li KY, Wang J, Tu LQ, Zhang J: [Mandibular swing procedure for surgical resection of advanced oropharyngeal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):302-4
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  • Immediate reconstruction of the surgical defect was done using tongue flap, pectoralis major myocutaneous flap, sternohyoid myofascial flap, temporalis myofascial flap and forehead flap, respectively.
  • CONCLUSION: The mandibular swing procedure and its combined approach is safe and effective in the surgical resection of the advanced oropharyngeal carcinoma, which can provide a good exposure for the oropharynx, supraglottic region, hypopharynx, the parapharyngeal space and the base of the skull.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Radiotherapy, Adjuvant. Survival Analysis

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  • (PMID = 17760261.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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85. Ming W, Hua Q, Zhan H: [Pharyngocutaneous fistula following total laryngectomy in patients with advanced stage hypopharyngeal or laryngeal carcinomas]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jun;22(12):542-3
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  • CONCLUSION: PCF is often situated in tongue base and post-superior of trachea stoma.
  • Tumor locations and postoperative fever are important predisposition.
  • [MeSH-minor] Adult. Aged. Female. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Incidence. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18800680.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Rapidis AD, Trichas M, Stavrinidis E, Roupakia A, Ioannidou G, Kritselis G, Liossi P, Giannakouras G, Douzinas EE, Katsilieris I: Induction chemotherapy followed by concurrent chemoradiation in advanced squamous cell carcinoma of the head and neck: final results from a phase II study with docetaxel, cisplatin and 5-fluorouracil with a four-year follow-up. Oral Oncol; 2006 Aug;42(7):675-84
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  • The site of the primary tumors was the anterior mouth in 9 pts, base of tongue and oropharynx in 12, middle third of the face in 8 and larynx in 13.
  • [MeSH-minor] Adult. Age Distribution. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Male. Middle Aged. Neoplasm Staging. Radiation Injuries / etiology. Radiotherapy / adverse effects. Remission Induction. Sex Distribution. Survival Analysis. Taxoids / administration & dosage. Taxoids / adverse effects. Treatment Outcome

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  • (PMID = 16731029.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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87. Sato K, Shimizu S, Oka H, Nakahara K, Utsuki S, Fujii K: Usefulness of transcervical approach for surgical treatment of hypoglossal schwannoma with paraspinal extension: case report. Surg Neurol; 2006 Apr;65(4):397-401, discussion 401
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  • The findings were of a tumor lying in the left hypoglossal canal and paraspinal region and were consistent with hypoglossal schwannoma.
  • Subtotal intracapsular removal of the tumor was performed via transcervical approach.
  • CONCLUSION: The transcervical approach and intracapsular removal of the tumor under electrophysiological monitoring provided for successful minimally invasive surgery in this case of hypoglossal schwannoma.
  • [MeSH-minor] Cervical Vertebrae / anatomy & histology. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Decompression, Surgical / methods. Electric Stimulation. Electromyography. Fasciculation / etiology. Fasciculation / pathology. Fasciculation / physiopathology. Female. Humans. Middle Aged. Monitoring, Physiologic. Neoplasm Recurrence, Local / prevention & control. Skull Base / pathology. Skull Base / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / physiopathology. Skull Base Neoplasms / surgery. Tongue / innervation. Tongue / physiopathology. Treatment Outcome

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  • (PMID = 16531208.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Konsulov SS: Carcinoma of the tongue base. Folia Med (Plovdiv); 2005;47(3-4):24-7
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  • [Title] Carcinoma of the tongue base.
  • AIM: This study reports the results of surgical treatment of patients with carcinoma of the base of tongue-supraglottic complex.
  • The base of the tongue, the epiglottic valleculae, preepiglottic space and supraglottic part of the larynx develop from one central region.
  • The proper term to refer to these structures is tongue base-supraglottic complex.
  • METHODS: Patients with squamous-cell carcinoma of the tongue base present usually in advanced stage of the disease.
  • All patients underwent supraglottic laryngectomy through suprahyoid pharyngectomy and extended resection of the tongue base that allowed sufficient visualization of the tumor.
  • RESULTS: Twenty-eight patients with carcinoma of the tongue base-supraglottic complex were treated in the Department of Ear, Nose and Throat Diseases of the Medical University Plovdiv between 2001 and 2004.
  • CONCLUSIONS: The supraglottic laryngectomy with suprahyoid pharyngectomy provides good exposure of the tumor in the area of the tongue base-supraglottic complex allowing thorough resection of the tumor and avoiding the functional and cosmetic defects characteristic of the combined method (mandibulotomy).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16761390.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bulgaria
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89. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • Immunohistochemical examination revealed that this tumor had neuroendocrine differentiation.
  • It was diagnosed as LCNEC of the tongue base.
  • Basal cells in the normal squamous epithelium around the tumor indicated positivity for neural cell adhesion molecule and N-cadherin.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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