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Items 1 to 88 of about 88
1. Serdar A, Basak D, Sercan G, Ali V: Solitary amyloid tumor of the tongue base. Int J Otolaryngol; 2009;2009:515068

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary amyloid tumor of the tongue base.
  • The purpose of this article is to present a rare case of localized, solitary amyloid tumor of tongue base and emphasize some of the characteristic features of challenging clinical and histopathologic diagnosis.
  • In this paper, we focused on the clinical and pathological specifications of this rare tumor, so any unnecessary examinations or measures may be spared.
  • Negative staining of amyloid material with AAC and osseous metaplasia noted in the histopathologic examination may not be thought as definite criteria for localized amyloidosis, but a supporter of localized, solitary amyloid tumor diagnosis.

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  • [Cites] Diagn Cytopathol. 2001 Mar;24(3):181-5 [11241901.001]
  • [Cites] Oral Oncol. 2006 Apr;42(4):421-9 [16488655.001]
  • [Cites] Am J Otolaryngol. 2004 May-Jun;25(3):186-9 [15124168.001]
  • [Cites] Diagn Cytopathol. 1993 Oct;9(5):570-5 [8287770.001]
  • (PMID = 20107570.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2809435
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2. Walid MS: Lymphoma of the base of the tongue: an incidental finding on the preoperative workup for a spine surgery. J Clin Med Res; 2009 Aug;1(3):184-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphoma of the base of the tongue: an incidental finding on the preoperative workup for a spine surgery.
  • Lymphoma of the tongue is very rare and accounts for 1% of all malignant tumors of the oral cavity.
  • During the preoperative workup for cervical spine surgery a tumor at the base of the tongue was discovered which was confirmed by pathology to be a lymphoma.
  • KEYWORDS: Lymphoma; Tongue; Spine surgery; Preoperative workup.

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  • (PMID = 22493655.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3318884
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3. Díaz Molina JP, Rodrigo JP, Llorente JL, Alvarez Marcos C, Moreno C, Suárez C: [Oncologic and functional results of surgical treatment for base of tongue carcinomas]. Acta Otorrinolaringol Esp; 2010 Sep-Oct;61(5):351-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Oncologic and functional results of surgical treatment for base of tongue carcinomas].
  • [Transliterated title] Resultados oncológicos y funcionales del tratamiento quirúrgico de los carcinomas de base de lengua.
  • INTRODUCTION AND OBJECTIVES: Squamous cell carcinomas at the base of the tongue are usually diagnosed at advanced stages, and their optimal treatment has not been established.
  • The aim of this study was to describe the functional and oncological outcomes of patients with base of tongue carcinomas treated with surgery.
  • MATERIALS AND METHODS: A retrospective study on 132 patients with base of tongue carcinoma surgically treated in our hospital between 1990 and 2007 was carried out.
  • CONCLUSIONS: The prognosis of squamous cell carcinomas of the base of the tongue is poor, especially in advanced stages.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Recovery of Function. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier España, S.L. All rights reserved.
  • (PMID = 20684822.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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4. Sugi M, Yanishi M, Shimada O, Kawakita S, Murota T, Shikata N: [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report]. Hinyokika Kiyo; 2008 May;54(5):373-6
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  • [Title] [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report].
  • Prostatic neuroendocrine (NE) carcinoma is a rare disease and the NE differentiation in prostate cancer is characterized by poor prognosis, rapidly progressing tumor and an androgen-independent state, for which there is currently no successful therapy.
  • Herein, we report a case of NE differentiatiated prostatic cancer, which metastasized to the base of tongue, intraorbit and brain stem.
  • This is the first Japanese report of prostate cancer metastasis to the brain stem and base of the tongue.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Stem Neoplasms / secondary. Carcinoma, Neuroendocrine / pathology. Cell Differentiation. Orbital Neoplasms / secondary. Prostatic Neoplasms / pathology. Tongue Neoplasms / secondary
  • [MeSH-minor] Androgen Antagonists / therapeutic use. Drug Resistance, Neoplasm. Humans. Male. Middle Aged


5. Kásler M, Fodor J, Oberna F, Major T, Polgár C, Takácsi-Nagy Z: Salvage surgery for locoregional failure after definitive radiotherapy for base of tongue cancer. In Vivo; 2008 Nov-Dec;22(6):803-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage surgery for locoregional failure after definitive radiotherapy for base of tongue cancer.
  • In this study, the results of definitive radiotherapy (RT) and salvage surgery treatment of base of tongue cancer were evaluated.
  • [MeSH-major] Carcinoma / surgery. Salvage Therapy / methods. Tongue Neoplasms / surgery
  • [MeSH-minor] Biopsy. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Postoperative Complications / classification. Survival Analysis. Survivors. Treatment Failure

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  • (PMID = 19181010.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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6. Hirunpat S, Jongsatitpaiboon J, Angunsri N, Chowchuvech V: When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma? Asian Pac J Cancer Prev; 2007 Apr-Jun;8(2):310-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma?
  • BACKGROUND AND PURPOSE: According to the American Joint Committee on Cancer (AJCC) cancer staging criteria (6th edition), cross-sectional imaging for base of tongue carcinoma is recommended when the deep tissue extent of a primary tumor is in question.
  • The aim of this study was to establish which group of patients MRI might most benefit from accurate clinical staging of base of tongue carcinomas.
  • PATIENTS AND METHODS: The clinical stagings of 33 patients with pathologically proven squamous cell carcinomas of the base of tongue were performed by two otorhinolaryngologic surgeons.
  • RESULTS: The tumor stages were changed in 13 of 33 patients (39.4%, 95% CI: 23.9-57.87%) and the overall stage groupings were changed in 10 (30.3 %, 95%CI: 15.6-48.7%) after performing MRI.
  • CONCLUSION: MRI should be recommended in base of tongue carcinoma whenever clinical examination suggests overall stage groupings II, III or tumor stage T3.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Reproducibility of Results

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  • (PMID = 17696753.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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7. Uzochukwu NO, Shrier DA, Lapoint RJ: Clear cell carcinoma of the base of the tongue: MR imaging findings. AJNR Am J Neuroradiol; 2007 Jan;28(1):127-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell carcinoma of the base of the tongue: MR imaging findings.
  • Clear cell carcinoma of the base of the tongue is a rare minor salivary gland neoplasm, and to our knowledge, the MR imaging appearance of this entity has not been described.
  • We present the MR imaging findings in such a case and review the differential diagnosis for tongue base masses in an adult.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Magnetic Resonance Imaging. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Deglutition Disorders / etiology. Diagnosis, Differential. Female. Humans. Laryngoscopy. Middle Aged. Tongue / pathology. Tongue / surgery

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  • (PMID = 17213438.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Deleyiannis FW, Lee E, Gastman B, Nguyen D, Russavage J, Manders EK, Ferris RL, Myers EN, Johnson J: Prognosis as a determinant of free flap utilization for reconstruction of the lateral mandibular defect. Head Neck; 2006 Dec;28(12):1061-8
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  • RESULTS: Age >or=70 years (p = .03), moderate or severe comorbidity (p = .02), and involvement of the base of tongue by tumor (p = .04) were significantly associated with decreased utilization of a free flap (n = 36).
  • [MeSH-major] Carcinoma / diagnosis. Head and Neck Neoplasms / diagnosis. Mandible / surgery. Reconstructive Surgical Procedures / methods. Sarcoma / diagnosis. Surgical Flaps


9. Wakisaka N, Murono S, Minato H, Furukawa M, Yoshizaki T: A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base. Auris Nasus Larynx; 2006 Dec;33(4):487-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base.
  • Here, we report on a case of undifferentiated carcinoma of the tongue base.
  • A 71-year-old male, who had been treated with irradiation for primary unknown right neck metastatic EBV-positive undifferentiated carcinoma 9 years previously, was referred to our clinic with masses at the tongue base and right neck.
  • The lesion at the tongue base was revealed to be an EBV-positive undifferentiated carcinoma.
  • He was treated with resection of tongue base tumor and bilateral-neck dissection, and the defect at the tongue base was reconstructed with a free rectus abdominis myocutaneous flap.
  • Re-irradiation was added post-operatively because of a positive surgical margin at the tongue base.
  • [MeSH-major] Carcinoma / virology. Herpesviridae Infections / complications. Herpesvirus 4, Human / isolation & purification. Tongue Neoplasms / virology. Tumor Virus Infections / complications

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  • (PMID = 16934421.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Silva P, Slevin NJ, Sloan P, Valentine H, Cresswell J, Ryder D, Price P, Homer JJ, West CM: Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1551-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer.
  • Currently most management decisions are based on clinical parameters with little appreciation of patient differences in underlying tumor biology.
  • We investigated the prognostic significance of clinicopathologic features and tumor hypoxia-inducible factor-1alpha (HIF-1alpha) expression in a homogeneous series of patients who underwent radiotherapy.
  • METHODS AND MATERIALS: An audit identified 133 consecutive patients with histologically proven squamous cell carcinoma of the tonsil or tongue base.
  • Tumor HIF-1alpha expression was examined in 79 patients.
  • 3.04-176.7) than the tongue-base tumor (HR, 2.86; 95% CI, 1.14-7.19) group (p = 0.03, test for interaction).
  • High tumor HIF-1alpha expression was associated with low blood Hb levels (p = 0.03).
  • The work highlights the importance of studying homogeneous groups of patients in HNSCC, and the complex interrelationships between tumor biology and clinicopathologic factors.
  • The establishment of tumor-type specific markers would represent a major advance in this area.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / radiotherapy. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / radiotherapy. Hemoglobins / metabolism. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Tongue Neoplasms / genetics. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / genetics. Tonsillar Neoplasms / radiotherapy. Treatment Outcome. Young Adult

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  • (PMID = 19028277.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hemoglobins; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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11. Adelson RT, Ducic Y: Metastatic head and neck carcinoma to a percutaneous endoscopic gastrostomy site. Head Neck; 2005 Apr;27(4):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the case at our institution, a 63-year-old man was referred to our institution with recurrent squamous cell carcinoma of the right base of tongue; he also had a 1.5-cm left apical lung nodule.
  • Six months after the original tube placement, he had an ulcerated mass develop at the PEG site; biopsy of the mass revealed squamous cell carcinoma histologically identical to the base of tongue tumor.
  • Direct implantation with a variable-sized initial tumor burden can explain all cases of PEG site metastasis.
  • Smaller initial tumor implants present later than would larger initial tumor burdens, when the patient is more likely to have distant metastatic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Enteral Nutrition. Gastroscopy. Gastrostomy. Muscle Neoplasms / secondary. Rectus Abdominis / pathology. Stomach Neoplasms / secondary. Tongue Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 15712297.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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12. Tixier H, Fraisse J, Bruchon Y, Cuisenier J: [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath]. J Chir (Paris); 2009 Oct;146(5):503-5
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  • [Title] [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath].
  • [Transliterated title] Métastase d'une tumeur de la base de langue sur un système d'accès veineux central totalement implantable.
  • We report a case of metastatic implantation at a port site from a primary cancer of the base of the tongue.
  • Insertion of portacaths must be performed using full sterile precautions to avoid spread of tumor cells; in no case should the port site incisions be in contact with the surgical field in which the tumor resection was performed.
  • [MeSH-major] Carcinoma, Squamous Cell. Catheterization, Central Venous / adverse effects. Infusion Pumps, Implantable / adverse effects. Oropharyngeal Neoplasms. Tongue Neoplasms
  • [MeSH-minor] Aged. Biopsy. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Positron-Emission Tomography. Skin Neoplasms / secondary. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19833338.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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13. Han P, Hu K, Frank DK, Sessions RB, Harrison LB: Management of cancer of the base of tongue. Otolaryngol Clin North Am; 2005 Feb;38(1):75-85, viii
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  • [Title] Management of cancer of the base of tongue.
  • The management of base of tongue cancer has evolved steadily over time.
  • This article reports the results of a literature review of base of tongue cancer emphasizing a multidisciplinary approach to obtain optimal results in terms of cure and quality of life.
  • [MeSH-major] Tongue Neoplasms / pathology. Tongue Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Glossectomy. Humans. Neoplasm Staging. Quality of Life. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 15649500.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 31
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14. Hans S, Chauvet D, Sadoughi B, Brasnu DF: Cardiac metastasis after squamous cell carcinoma of the base of tongue. Am J Otolaryngol; 2009 May-Jun;30(3):206-8
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  • [Title] Cardiac metastasis after squamous cell carcinoma of the base of tongue.
  • We report a case of squamous cell carcinoma of the base of tongue secondarily complicated with cardiac metastasis 6 months after surgical treatment resulted in successful local control.
  • CONCLUSIONS: Cardiac metastasis should be suspected when new cardiovascular symptoms are observed in patients with a history of head and neck neoplasm.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Heart Neoplasms / secondary. Tongue Neoplasms / pathology

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  • (PMID = 19410127.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Briem B, Magnúsdóttir AB: [Lingual thyroid--case report: a woman with a tumor at the base of the tongue]. Laeknabladid; 2005 Sep;91(9):661-3

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  • [Title] [Lingual thyroid--case report: a woman with a tumor at the base of the tongue].
  • Laryngostroboscopy showed a mass lesion at the base of the tongue.
  • On examination a mass is noted at the base of the tongue and the diagnosis is then confirmed with CT/MRI and thyroid scanning.

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  • (PMID = 16155337.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Iceland
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16. Konsulov SS: Carcinoma of the tongue base. Folia Med (Plovdiv); 2005;47(3-4):24-7

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  • [Title] Carcinoma of the tongue base.
  • AIM: This study reports the results of surgical treatment of patients with carcinoma of the base of tongue-supraglottic complex.
  • The base of the tongue, the epiglottic valleculae, preepiglottic space and supraglottic part of the larynx develop from one central region.
  • The proper term to refer to these structures is tongue base-supraglottic complex.
  • METHODS: Patients with squamous-cell carcinoma of the tongue base present usually in advanced stage of the disease.
  • All patients underwent supraglottic laryngectomy through suprahyoid pharyngectomy and extended resection of the tongue base that allowed sufficient visualization of the tumor.
  • RESULTS: Twenty-eight patients with carcinoma of the tongue base-supraglottic complex were treated in the Department of Ear, Nose and Throat Diseases of the Medical University Plovdiv between 2001 and 2004.
  • CONCLUSIONS: The supraglottic laryngectomy with suprahyoid pharyngectomy provides good exposure of the tumor in the area of the tongue base-supraglottic complex allowing thorough resection of the tumor and avoiding the functional and cosmetic defects characteristic of the combined method (mandibulotomy).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16761390.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bulgaria
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17. Tincani AJ, Altemani A, Martins AS, Barreto G, Valério JB, Del Negro A, Araújo PP: Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location. Ear Nose Throat J; 2005 Dec;84(12):794-5, 799
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  • [Title] Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate.
  • We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck.
  • The tumor was resected through the oral cavity with wide margins and dissection.
  • [MeSH-major] Adenocarcinoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16408562.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Henstrom DK, Moore EJ, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1231-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral resection for squamous cell carcinoma of the base of the tongue.
  • OBJECTIVE: To review the oncologic and functional outcomes of patients with squamous cell carcinoma of the base of the tongue who underwent transoral tumor resection and neck dissection with or without postoperative adjuvant therapy.
  • PATIENTS: All patients undergoing transoral resection of squamous cell carcinoma on the base of the tongue as part of their primary treatment from January 1, 1996, through January 31, 2005.
  • CONCLUSIONS: Transoral resection of squamous cell carcinoma of the base of the tongue with postoperative adjuvant therapy provided excellent local and regional control and minimized morbidity.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Enteral Nutrition. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 20026821.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Pujary K, Rangarajan S, Nayak DR, Balakrishnan R, Ramakrishnan V: Hyalinizing clear cell carcinoma of the base of tongue. Int J Oral Maxillofac Surg; 2008 Jan;37(1):93-6
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  • [Title] Hyalinizing clear cell carcinoma of the base of tongue.
  • Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands.
  • There are only a few isolated cases reported in the literature involving the base of tongue.
  • A 57-year-old male patient presented with a lesion in the base of tongue, which was well enhanced on contrast computerized tomography scan.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Salivary Gland Neoplasms / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17822882.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Laccourreye O, Seccia V, Ménard M, Garcia D, Vacher C, Holsinger FC: Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base. Ann Otol Rhinol Laryngol; 2009 Jun;118(6):428-34
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  • [Title] Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base.
  • OBJECTIVES: In a retrospective review of an inception cohort of 26 patients with an isolated, previously untreated, moderately to well-differentiated invasive squamous cell carcinoma of the lateral tongue base, consecutively managed with an extended lateral pharyngotomy approach at a single tertiary referral care center, the authors review the key surgical points, highlight the potential technical pitfalls, and document the complications and long-term functional and oncological outcomes in terms of survival and local control.
  • The main causes of death were metachronous second primary tumor, intercurrent disease, and distant metastasis, resulting in 84.6%, 64%, and 46.9% 1-, 3-, and 5-year Kaplan-Meier actuarial survival estimates, respectively.
  • CONCLUSIONS: Such results suggest that extended lateral pharyngotomy should be integrated among the various conservative treatment options available to patients with selected carcinomas of the lateral tongue base.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neck Dissection / methods. Pharynx / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19663374.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Petruson K, Mercke C, Lundberg LM, Silander E, Hammerlid E: Longitudinal evaluation of patients with cancer in the oral tongue, tonsils, or base of tongue--does interstitial radiation dose affect quality of life? Brachytherapy; 2005;4(4):271-7
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  • [Title] Longitudinal evaluation of patients with cancer in the oral tongue, tonsils, or base of tongue--does interstitial radiation dose affect quality of life?
  • PURPOSE: To evaluate health-related quality of life (HRQL) in patients with oral tongue, tonsil, or base of tongue cancer in a prospective longitudinal study and explore correlations between HRQL scores and interstitial radiation dose, dose rate, and volume of implant.
  • METHODS AND MATERIALS: Ninety patients with oral tongue cancer (n=30) and tonsil or base of tongue cancer (n=60) were assessed with the European Organization of Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and the European Organization of Research and Treatment of Cancer Head and Neck module at diagnosis, and after 3, 12, and 36 months of starting treatment.
  • Most HRQL scores returned to baseline values after 3 years; however, 60% of patients with oral tongue cancer and 80% with tonsil and base of tongue cancer reported problems with dry mouth and half of the patients with tonsil and base of tongue cancer reported problems with swallowing solid food at the 3-year followup.
  • CONCLUSIONS: Patients with oral tongue, tonsil, or base of tongue cancer reported significant problems with dry mouth and swallowing solid food throughout this 3-year followup study.
  • [MeSH-major] Brachytherapy. Quality of Life. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Health Status. Humans. Male. Middle Aged. Neoplasm Staging. Patient Compliance. Prospective Studies. Radiotherapy Dosage. Surveys and Questionnaires. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16344257.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Hancock SB, Krempl GA, Canfield V, Bogardus C, Kojouri K, Kaneaster SK, Medina JE: Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. Laryngoscope; 2008 Aug;118(8):1357-61
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  • [Title] Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy.
  • OBJECTIVES/HYPOTHESIS: To assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage III and IV base of tongue cancer.
  • STUDY DESIGN: Subgroup analysis of patients with base of tongue cancer enrolled in a single-institution prospective phase II trial, evaluating an organ-preservation approach in the treatment of locally advanced head and neck cancer.
  • If the primary tumor exhibited a complete or partial response, patients were treated with radiation and weekly taxol and carboplatin for 7 weeks.
  • CONCLUSIONS: The treatment regimen studied is remarkably effective in stage III and IV base of tongue cancer with 100% of patients completing the protocol alive to date.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Disease-Free Survival. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Nervous System Diseases / chemically induced. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 18528311.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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23. Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW, Werning JW, Villaret DB: Definitive radiotherapy for squamous cell carcinoma of the base of tongue. Am J Clin Oncol; 2006 Feb;29(1):32-9
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  • [Title] Definitive radiotherapy for squamous cell carcinoma of the base of tongue.
  • OBJECTIVE: To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer.
  • METHODS: There were 333 patients with squamous cell carcinoma of the base of tongue treated with definitive RT and had follow-up from 0.2 to 26.2 years.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Retrospective Studies. Treatment Outcome

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  • (PMID = 16462500.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Vidiri A, Ruscito P, Pichi B, Pellini R, Covello R, Sperduti I, Di Giovanni S, Spriano G, Crecco M: Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor. J Exp Clin Cancer Res; 2007 Dec;26(4):575-82
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  • [Title] Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor.
  • The diagnosis of oral cavity and oropharyngeal tumors can be obtained through clinical examination and biopsy.
  • The aim of this study was to define the accuracy of clinical and MRI T staging of oral cavity and base of the tongue tumors and correlate the results with pathological data.
  • [MeSH-major] Magnetic Resonance Imaging. Mouth Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Male. Mouth / pathology. Neoplasm Staging

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  • (PMID = 18365555.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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25. Kumai Y, Ogata N, Yumoto E: Epithelial-myoepithelial carcinoma in the base of the tongue: a case report. Am J Otolaryngol; 2006 Jan-Feb;27(1):58-60
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  • [Title] Epithelial-myoepithelial carcinoma in the base of the tongue: a case report.
  • OBJECTIVES: To report a rare case of epithelial-myoepithelial carcinoma (EMC) of a minor salivary gland originating in the base of the tongue, which is a highly unusual location.
  • Endoscopic examination revealed a tumorous lesion 40 x 20 mm in the base of the tongue on the left side.
  • The final diagnosis based on the histological and immunohistochemical findings was EMC.
  • Because neither histological evidence of residual tumor in the surgical margin nor neck metastases were found, radiotherapy was not performed.
  • CONCLUSION: We believe this report is the first description of EMC originating in the base of the tongue.
  • [MeSH-major] Carcinoma / pathology. Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Neoplasm Staging. Oral Surgical Procedures / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 16360826.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Yoshimoto S, Kawabata K, Mitani H, Yonekawa H, Beppu T, Fukushima H, Sasaki T: Treatment results for 84 patients with base of tongue cancer. Acta Otolaryngol Suppl; 2007 Dec;(559):123-8
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  • [Title] Treatment results for 84 patients with base of tongue cancer.
  • OBJECTIVES: Because tumors originating from the base of the tongue are rare, few large-scale studies of such tumors have been performed.
  • PATIENTS AND METHODS: From 1971 to 2000, 84 patients with previously untreated and resectable squamous cell carcinoma of the base of the tongue were treated at the Head and Neck Department of the Cancer Institute Hospital, Tokyo.
  • [MeSH-major] Carcinoma, Squamous Cell. Tongue Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Hypopharyngeal Neoplasms / secondary. Laryngectomy. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Preoperative Care

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  • (PMID = 18340583.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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27. van Lierop AC, Basson O, Fagan JJ: Is total glossectomy for advanced carcinoma of the tongue justified? S Afr J Surg; 2008 Feb;46(1):22-5
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  • [Title] Is total glossectomy for advanced carcinoma of the tongue justified?
  • Total glossectomy (with or without total laryngectomy) followed by postoperative radiotherapy remains the principal treatment method for advanced base of tongue carcinoma.
  • METHODS: We did a retrospective chart review of all patients at Groote Schuur Hospital, Cape Town, who had undergone total glossectomy, with or without total laryngectomy, for stage IV squamous cell carcinoma (SCC) of the tongue between 1998 and 2004.
  • CONCLUSION: Advanced SCC of the tongue is a devastating disease causing severe pain and disorders of speech and swallowing.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Glossectomy. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 18468419.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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28. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • Immunohistochemical examination revealed that this tumor had neuroendocrine differentiation.
  • It was diagnosed as LCNEC of the tongue base.
  • Basal cells in the normal squamous epithelium around the tumor indicated positivity for neural cell adhesion molecule and N-cadherin.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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29. Jegannathen A, Swindell R, Yap B, Lee L, Sykes A, Mais K, Sanghera P, Hartley A, Glaholm J, Slevin N: Can synchronous chemotherapy be added to accelerated hypofractionated radiotherapy in patients with base of tongue cancer? Clin Oncol (R Coll Radiol); 2010 Apr;22(3):185-91
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  • [Title] Can synchronous chemotherapy be added to accelerated hypofractionated radiotherapy in patients with base of tongue cancer?
  • AIM: To evaluate the tolerability of synchronous chemotherapy and accelerated hypofractionated radiotherapy in patients with locally advanced squamous cell carcinoma of the base of the tongue.
  • MATERIALS AND METHODS: Between 1999 and 2004, 43 patients with stage II-IV squamous cell carcinoma of the base of the tongue were treated with a combined modality of radiotherapy (prescribed 55 Gy in 20 fractions), synchronous chemotherapy and in some cases surgical neck dissection.
  • Tumour control rates compare well with published outcomes.
  • However, the tumour site investigated and the choice of synchronous chemotherapy agent may also be important.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Squamous Cell / therapy. Radiotherapy / methods. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging

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  • [Copyright] Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20116980.001).
  • [ISSN] 1433-2981
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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30. Grant DG, Salassa JR, Hinni ML, Pearson BW, Perry WC: Carcinoma of the tongue base treated by transoral laser microsurgery, part two: Persistent, recurrent and second primary tumors. Laryngoscope; 2006 Dec;116(12):2156-61

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  • [Title] Carcinoma of the tongue base treated by transoral laser microsurgery, part two: Persistent, recurrent and second primary tumors.
  • OBJECTIVES: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of persistent, recurrent, and second primary squamous cell carcinoma of the tongue base.
  • METHODS: Twenty-five patients with persistent, recurrent, or second primary squamous cell carcinoma of the tongue base were treated with TLM between 1997 and 2005.
  • CONCLUSIONS: Transoral laser surgery is a rational and effective treatment in appropriately selected patients with persistent, recurrent, or second primary tongue base cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laser Therapy. Microsurgery / methods. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / surgery. Tongue Neoplasms / surgery

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  • (PMID = 17146389.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Ye H, Yu T, Temam S, Ziober BL, Wang J, Schwartz JL, Mao L, Wong DT, Zhou X: Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics; 2008;9:69
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  • [Title] Transcriptomic dissection of tongue squamous cell carcinoma.
  • The oral tongue squamous cell carcinoma (OTSCC) is one of the most common types of HNOSCC.
  • CONCLUSION: In summary, our study provided a transcriptomic signature for OTSCC that may lead to a diagnosis or screen tool and provide the foundation for further functional validation of these specific candidate genes for OTSCC.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Expression Profiling. Tongue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. Biomarkers / metabolism. Case-Control Studies. Collagen / metabolism. DNA Primers / genetics. Female. Humans. Immunohistochemistry. Interleukin-8 / genetics. Interleukin-8 / metabolism. Male. Matrix Metalloproteinase 9 / genetics. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Oligonucleotide Array Sequence Analysis. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18254958.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / K22 DE014847; United States / NCI NIH HHS / CA / P01 CA106451; United States / NIDCR NIH HHS / DE / R01 DE015970; United States / NCI NIH HHS / CA / R03 CA114688; United States / NIDCR NIH HHS / DE / R03 DE016569
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / DNA Primers; 0 / IL8 protein, human; 0 / Interleukin-8; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 9007-34-5 / Collagen; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC2262071
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32. Yang AK, Liu TR, Chen FJ, Ma XF, Guo ZM, Song M, Li QL, Zeng ZY: [Survival analysis of 229 patients with advanced squamous cell carcinoma of the oral tongue]. Ai Zheng; 2008 Dec;27(12):1315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Survival analysis of 229 patients with advanced squamous cell carcinoma of the oral tongue].
  • BACKGROUND & OBJECTIVE: Patients with advanced squamous cell carcinoma (SCC) of the oral tongue have poor prognosis.
  • This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) SCC of the oral tongue.
  • METHODS: Complete clinical and follow-up data of 229 patients with pathologically confirmed advanced SCC of the oral tongue, initially treated at Sun Yat-sen University Cancer Center were retrospectively analyzed.
  • Univariate analysis showed that age, tongue base invasion, cervical lymphatic metastasis, stage, surgical treatment, recurrence and residual tumor were risk factors affecting prognosis (P<0.05).
  • Multivariate analysis indicated that tumour invasion across the midline, cervical lymphatic metastases, surgical treatment, recurrence and residual tumor were independent factors for prognosis.
  • CONCLUSIONS: The prognosis of patients with advanced SCC of the oral tongue is poor.
  • Tumour invasion across the midline, cervical lymphatic metastasis, surgical treatment, recurrence, and residual tumor are independent factors affecting the prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell. Glossectomy / methods. Neoplasm Recurrence, Local. Tongue Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging. Neoplasm, Residual. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Factors. Survival Analysis. Survival Rate. Young Adult


33. Treaba DO, Eklund JW, Wayne J, Nelson BP, Winter JN: Classical Hodgkin's lymphoma presenting with tongue involvement: a case report and review of the literature. Clin Lymphoma Myeloma; 2006 Mar;6(5):410-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Classical Hodgkin's lymphoma presenting with tongue involvement: a case report and review of the literature.
  • We report an unusual case of mixed cellularity classical Hodgkin's lymphoma with prominent involvement of the base of the tongue at diagnosis.
  • Waldeyer's ring involvement by Hodgkin's lymphoma is uncommon with < 200 cases reported in the English literature and only 5 previous reports of Hodgkin's lymphoma involving the tongue.
  • [MeSH-major] Hodgkin Disease / drug therapy. Hodgkin Disease / pathology. Tongue Neoplasms / drug therapy. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16640820.001).
  • [ISSN] 1557-9190
  • [Journal-full-title] Clinical lymphoma & myeloma
  • [ISO-abbreviation] Clin Lymphoma Myeloma
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA60553-12
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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34. Mackle T, O'Dwyer T: A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review. J Laryngol Otol; 2006 May;120(5):393-6
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  • [Title] A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review.
  • INTRODUCTION: The study sought to compare and contrast squamous cell carcinoma (SCC) of the anterior mobile tongue with SCC of the tongue base, with emphasis on clinical presentation, management and outcome.
  • METHODS: This was a retrospective, comparative analysis of patients treated for SCC of the tongue over a 10-year period.
  • Cox's regression model was used to assess the effect of tumour site on survival.
  • RESULTS: The study included 142 patients, of whom 86 were treated for SCC of the anterior tongue and 56 for tongue base lesions.
  • Patients with carcinoma of the anterior tongue tended to present with a visible lump or ulceration of the tongue, whereas the majority of patients with tongue base SCC presented with pain.
  • Sixty per cent of anterior tongue lesions were early stage (I or II) at initial presentation as compared with 21 per cent of tongue base lesions.
  • CONCLUSION: Patients with anterior tongue lesions had a better prognosis, but this was not statistically significant when adjusted for stage.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Regression Analysis. Retrospective Studies. Sex Distribution. Survival Rate

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  • (PMID = 16563198.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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35. Hillyer S, Vicens JC, Levinson H, Bhayani R, Mesea L, Chaudhry R, Fayans E, Fogler R: Alveolar soft-part sarcoma of the tongue in a 17-month-old. Ear Nose Throat J; 2009 Oct;88(10):E4-9
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  • [Title] Alveolar soft-part sarcoma of the tongue in a 17-month-old.
  • Alveolar soft-part sarcoma (ASPS) is a rare and often fatal tumor.
  • In children, ASPS rarely occurs in the oral cavity, and to the best of our knowledge, only 12 cases of ASPS of the tongue occurring during the first decade of life have been previously reported in the literature.
  • Our patient was a 17-month-old girl whose tumor was located at the base of the tongue.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Staging. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Radionuclide Imaging. Sodium Pertechnetate Tc 99m. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 19826991.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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36. Gupta R, Gupta K, Gupta R: Polymorphous low-grade adenocarcinoma of the tongue: a case report. J Med Case Rep; 2009;3:9313

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  • [Title] Polymorphous low-grade adenocarcinoma of the tongue: a case report.
  • INTRODUCTION: Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions.
  • In rare cases, the mass can also occur in the tongue.
  • We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.
  • CASE PRESENTATION: A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa.
  • Its occurrence in the tongue is rare with very few cases reported in the literature.
  • It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.

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  • (PMID = 20062742.001).
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  • [Language] eng
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  • [Other-IDs] NLM/ PMC2803836
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37. Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X: MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett; 2010 Sep 24;584(18):4115-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
  • Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear.

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  • [Copyright] Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 20816961.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NCI NIH HHS / CA / R01 CA139596-03; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / CA139596-03; United States / NIDCR NIH HHS / DE / K22 DE014847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Dnd1 protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / MIRN24 microRNA, human; 0 / MicroRNAs; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ NIHMS234020; NLM/ PMC2964934
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38. Lam L, Logan RM, Luke C, Rees GL: Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004. Oral Oncol; 2007 Feb;43(2):150-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004.
  • This is a retrospective study of patients with oral and oropharyngeal tongue cancers who presented to the Royal Adelaide Hospital (RAH) from 1987 to 2004.
  • The aims of this study were to determine sociodemographic and tumour characteristics, treatment patterns and five-year disease-specific survival of the disease.
  • All cases of tongue cancers, including untreated and palliative cases, were identified through the Royal Adelaide Hospital Cancer Registry and were included in statistical analysis.
  • A total of 212 cases of tongue cancer were identified.
  • Almost 30% of recorded cases were oropharyngeal or base of tongue cancers.
  • Nearly half of the patients had advanced stage (III and IV) disease at presentation, which was significantly associated with rural area of residence, base of tongue sub-site and early diagnostic period.
  • Palliative treatment was more likely to be given to patient with oropharyngeal tongue cancers or advance stage disease.
  • Poorer survival was significantly associated with age 45 years or older, oropharyngeal tongue cancers and advanced stage disease.
  • Tongue cancer is an important health issue associated with poor survival.
  • Early detection and diagnosis is important in order to improve survival rate for this malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Oropharyngeal Neoplasms / therapy. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Epidemiologic Methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palliative Care / utilization. Prognosis. Treatment Outcome

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  • (PMID = 16807069.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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39. Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X: Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer; 2010 Aug 1;127(3):505-12
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
  • Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC).

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  • (PMID = 20232393.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NIDCR NIH HHS / DE / DE014847-05S1; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / R03 CA135992-01A1; United States / NCI NIH HHS / CA / CA135992-01A1; United States / NIDCR NIH HHS / DE / K22 DE014847; United States / NIDCR NIH HHS / DE / K22 DE014847-05S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RHOC protein, human; 0 / RNA, Messenger; 0 / ROCK2 protein, human; EC 2.7.11.1 / rho-Associated Kinases; EC 3.6.5.2 / rho GTP-Binding Proteins
  • [Other-IDs] NLM/ NIHMS203801; NLM/ PMC2885137
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40. Chennupati SK, Norris R, Dunham B, Kazahaya K: Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol; 2008 Jan;72(1):115-9
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  • [Title] Osteosarcoma of the skull base: case report and review of literature.
  • Osteosarcomas are an aggressive neoplasm composed of spindle cells producing osteoid.
  • A case report presentation of a skull base osteosarcoma in a teenage female.
  • There were also findings consistent with chronic denervation of her right tongue and pharynx.
  • Repeat imaging revealed progression of the skull base lesion with extension into the right sphenoid sinus.
  • The diagnosis of high-grade osteosarcoma was made by histologic morphology and immunohistochemistry.
  • Osteosarcoma of the skull base is a rare entity.
  • [MeSH-major] Osteosarcoma / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 17980919.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 9
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41. Cakli H, Altin F, Ak I, Gürbüz MK, Ozüdoğru E: [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report]. Kulak Burun Bogaz Ihtis Derg; 2005;14(1-2):39-43
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report].
  • Investigation with positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose suggested the base of the tongue as the primary site, which was then confirmed by an endoscopic biopsy from the tongue.
  • It should be borne in mind that positron emission tomography may be helpful in the diagnosis of unknown primary tumors with cervical metastasis.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Neoplasms, Unknown Primary / diagnosis. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / radiography. Neoplasms, Unknown Primary / surgery. Positron-Emission Tomography

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  • (PMID = 16227723.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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42. Vlajinac HD, Marinkovic JM, Sipetic SB, Andrejic DM, Adanja BJ, Stosic-Divjak SL: Case-control study of oropharyngeal cancer. Cancer Detect Prev; 2006;30(2):152-7
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  • BACKGROUND: In order to test some hypotheses of risk factors for oropharyngeal cancer (neoplasm of base of tongue, palate and tonsils) matched case-control study was conducted in Belgrade, Serbia and Montenegro, during the period 1998-2000.

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  • (PMID = 16647226.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Carcinogens, Environmental; 0 / Dust
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43. Sundaram K, Schwartz J, Har-El G, Lucente F: Carcinoma of the oropharynx: factors affecting outcome. Laryngoscope; 2005 Sep;115(9):1536-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES/HYPOTHESIS: To assess the value of both patient- and tumor-related factors of oropharyngeal squamous cell carcinoma in predicting patient outcome, with respect to the three primary subsites of the disease.
  • 1) base of tongue, 2) tonsil and pillars, and 3) uvula, soft palate, and posterior pharyngeal wall.
  • Tumor-related factors included American Joint Committee on Cancer stage, T stage, N stage, and grade.
  • RESULTS: Tumor-related factors such as American Joint Committee on Cancer stage (P = .016) and T stage (P = .008) had a significant impact on treatment response.
  • Base-of-tongue lesions responded significantly worse to treatment than did tonsil and pillar or uvula, soft palate, and posterior pharyngeal wall lesions (P = .014).
  • The disease-free survival for base-of-tongue cancer was significantly worse than for tonsil and pillar or for uvula, soft palate, and posterior pharyngeal wall cancer (P = .010).
  • Important tumor-related factors were the American Joint Committee on Cancer stage and the T stage.
  • Among the oropharyngeal subsites, squamous cell carcinoma of the base of tongue was associated with the worst outcome.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palate, Soft. Sex Factors. Tongue. Tonsillar Neoplasms. Treatment Outcome. Uvula

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  • (PMID = 16148691.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Nakamura T, Kodaira T, Tachibana H, Tomita N, Yokouchi J, Fuwa N: Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy. Oral Oncol; 2009 Sep;45(9):830-4
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  • Nine patients who had a tumor in the base of the tongue were also treated with arterial infusion chemotherapy.
  • The 5-year local control rate for each subsite was: anterior wall, 90%; lateral wall, 80%; posterior wall, 67%; and superior wall, 64%.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy / methods. Disease-Free Survival. Feasibility Studies. Female. Fluorouracil / administration & dosage. Humans. Japan. Male. Middle Aged. Neoplasm Recurrence, Local. Organoplatinum Compounds / administration & dosage. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 19457713.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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45. Xie J, Dong P, Jin B, Li KY, Wang J, Tu LQ, Zhang J: [Mandibular swing procedure for surgical resection of advanced oropharyngeal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):302-4

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  • Immediate reconstruction of the surgical defect was done using tongue flap, pectoralis major myocutaneous flap, sternohyoid myofascial flap, temporalis myofascial flap and forehead flap, respectively.
  • CONCLUSION: The mandibular swing procedure and its combined approach is safe and effective in the surgical resection of the advanced oropharyngeal carcinoma, which can provide a good exposure for the oropharynx, supraglottic region, hypopharynx, the parapharyngeal space and the base of the skull.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Radiotherapy, Adjuvant. Survival Analysis

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  • (PMID = 17760261.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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46. Munck K, Ali MJ, Murr AH, Goldberg AN: Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma. Laryngoscope; 2005 Jul;115(7):1283-7

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  • [Title] Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma.
  • OBJECTIVE: To examine the impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring cancers by comparing the experience of a public hospital and an academic tertiary care medical center.
  • Patients included in the study had a histologic diagnosis of Waldeyer's ring carcinoma, primary treatment with radiation, and no prior treatment of Waldeyer's ring carcinoma.
  • MAIN OUTCOME MEASURES: The time of diagnosis to start of radiation therapy, dose of radiation, number of treatment days, duration of treatment, and 1 and 3 year survival were recorded.
  • RESULTS: The time course from diagnosis of nasopharyngeal carcinoma to start of radiation therapy was 56 days at SFGH compared with 34 days at UCSFMC.
  • Difference in diagnosis to treatment intervals for base of tongue cancer was also significant at 66 days at SFGH compared with 31 days at UCSFMC (P = .0038).
  • For cancer of the tonsil, the diagnosis to treatment interval was 70 days at SFGH versus 40 days at UCSFMC (P = .0005).
  • [MeSH-major] Carcinoma / pathology. Carcinoma / radiotherapy. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / pathology. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Academic Medical Centers. Biopsy. California. Follow-Up Studies. Hospitals, Public. Humans. Neoplasm Staging. Radiotherapy / statistics & numerical data. Retrospective Studies. Socioeconomic Factors. Survival Rate. Time Factors

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  • (PMID = 15995522.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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47. Rivera H, Nikitakis NG, Correnti M, Maissi S, Ponce JG: Oral and oropharyngeal cancer in a Venezuelan population. Acta Odontol Latinoam; 2008;21(2):175-80
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  • We clinically evaluated 130 patients with OC and OPC and a histopathologic diagnosis of squamous cell carcinoma.
  • The most common oropharyngeal anatomic location was the base of the tongue (22.3%), followed by the tonsils (13.9%), while the most frequently affected oral location was the oral tongue (19.2%) followed by the gingiva and alveolar mucosa (10.8%), and the floor of mouth (7.7%).
  • Most tumors were diagnosed at an advanced stage with a high incidence of metastatic spread to the regional lymph nodes, indicating possible delays in diagnosis.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Alcohol Drinking / epidemiology. Cell Differentiation. Female. Gingival Neoplasms / epidemiology. Humans. Lymphatic Metastasis. Male. Middle Aged. Mouth Floor / pathology. Mouth Mucosa / pathology. Neoplasm Staging. Prognosis. Sex Factors. Smoking / epidemiology. Tongue Neoplasms / epidemiology. Tonsillar Neoplasms / epidemiology. Venezuela / epidemiology

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  • (PMID = 19177856.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
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48. Törnwall J, Snäll J, Mesimäki K: A rare case of spinal cord metastases from oral SCC. Br J Oral Maxillofac Surg; 2008 Oct;46(7):594-5
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  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Spinal Cord Neoplasms / secondary. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Neoplasm Recurrence, Local / pathology. Palliative Care. Skull Base Neoplasms / secondary. Thoracic Vertebrae / pathology

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  • (PMID = 18359540.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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49. Galli J, Valenza V, Parrilla C, Galla S, Marchese MR, Castaldi P, Almadori G, Paludetti G: Pharyngocutaneous fistula onset after total laryngectomy: scintigraphic analysis. Acta Otorhinolaryngol Ital; 2009 Oct;29(5):242-4
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  • In case 1, the test showed a wide pharyngocutaneous fistula the internal orifice of which was at the level of the base of the tongue: on the scintigraphic images, the radiomarked water bolus, from the fistulous orifice, descended along the stoma walls and only a small part reached the oesophagus.
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Humans. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging

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  • [Cites] Ann Otol Rhinol Laryngol. 2000 Aug;109(8 Pt 1):787-90 [10961815.001]
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  • (PMID = 20162023.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2821128
  • [Keywords] NOTNLM ; Complications / Fistula / Scintigraphy / Total laryngectomy
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50. Firat Y, Aygenç E, Firat AK, Oto A, Selçuk A, Firat MM, Ozdem C: Computed tomography virtual laryngoscopy: comparison between radiological and otolaryngological evaluations for laryngeal carcinoma. Kulak Burun Bogaz Ihtis Derg; 2006;16(3):97-104
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  • RESULTS: Lesions localized in the base of the tongue, pyriform sinus, aryepiglottic folds, and arytenoids were well visualized by both RTV and CTVL.
  • CONCLUSION: Virtual laryngoscopy is a noninvasive and reliable technique that provides visualization of endolaryngeal surfaces and tumor extension.
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Processing, Computer-Assisted / methods. Male. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 16763426.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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51. Suzuki H, Katoh A, Udaka T, Shiomori T, Fujimura T, Fujimura K, Kitamura T: Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol; 2006 Jun;126(6):653-6
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  • [Title] Hyalinizing clear cell carcinoma arising from the base of the tongue.
  • Hyalinizing clear cell carcinoma is a low-grade indolent and rare salivary gland tumor originally described by Milchgrub et al. in 1994.
  • We herein report a case of this tumor of the base of the tongue.
  • Computed tomography and magnetic resonance imaging revealed a 40x30-mm well-defined ovoid tumor arising from the base of the tongue.
  • She underwent tracheostomy followed by a resection of the tumor via the transmandibular approach combined with a right-sided supra-omohyoid neck dissection.
  • Because the tumor invasion of the surrounding tissue was limited, the surgical defect at the base of the tongue was relatively small, and no reconstructive procedure needed to be performed.
  • The tumor was histopathologically diagnosed as hyalinizing clear cell carcinoma of the minor salivary gland.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Hyalin. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laryngoscopy. Magnetic Resonance Imaging. Neck Dissection. Stromal Cells / pathology. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 16720452.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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52. Pabiszczak M, Wierzbicka M, Szyfter W: [Localisation and direction of spread in oral and oropharyngeal cancer in the material of Head and Neck Oncological Surgery Department, University of Medical Sciences in Poznań]. Otolaryngol Pol; 2005;59(2):201-7
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  • The directions of tumor spread are determined by the anatomy of the affected organ.
  • The vessel, nerve anatomy and presence of structures, that may potentially constitute a barrier for spread out of the tumor are of crucial importance.
  • The examination was conducted on the base of retrospective analysis of ambulatory charts and the hospital files.
  • The primary localization included in the palatine tonsil (82 patients), trunk of the tongue (48 patients) and floor of the mouth (20 patients) were predominated.
  • The spread directions included: floor of the mouth (36) soft palate (35), base of tongue (33), hypopharynx (20) and trunk of tongue (16).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Poland. Retrospective Studies

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  • (PMID = 16095088.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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53. Shiley SG, Hargunani CA, Skoner JM, Holland JM, Wax MK: Swallowing function after chemoradiation for advanced stage oropharyngeal cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):455-9
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  • Most patients had base of tongue lesions (67%) and Stage IV disease (93%).
  • A higher rate of G-tube dependence was observed in patients treated for base of tongue lesions vs tonsil lesions (67% vs 25%, P = 0.049, chi(2) analysis).
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Enteral Nutrition. Female. Follow-Up Studies. Gastrostomy. Humans. Male. Middle Aged. Neoplasm Staging. Parenteral Nutrition. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 16500444.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Kutter J, Ozsahin M, Monnier P, Stupp R: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):1-7
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  • The primary tumor involved the hypopharynx (n=7), base of the tongue (n=10), nasopharynx (n=2) or upper esophagus (n=1) or its location was unknown (n=3).
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / drug therapy. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Amifostine / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage

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  • (PMID = 15004704.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] M487QF2F4V / Amifostine; Q20Q21Q62J / Cisplatin
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55. Kreeft A, Tan IB, van den Brekel MW, Hilgers FJ, Balm AJ: The surgical dilemma of 'functional inoperability' in oral and oropharyngeal cancer: current consensus on operability with regard to functional results. Clin Otolaryngol; 2009 Apr;34(2):140-6
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  • OBJECTIVES: If surgical resection of a tumour results in an unacceptable loss of function, this is defined as 'functional inoperability'.
  • DESIGN: A web base survey.
  • MAIN OUTCOME MEASURES: Assessment of functional results after tumour resection in twenty-two statements and five cases.
  • There is no absolute consensus about the functional outcome after certain surgical procedures, namely: bilateral maxillectomy, resection of a tonsil and resection of base of tongue carcinoma including removal of the vallecula and epiglottis, and total soft palate resection.
  • Disagreement of operability is also observed for T3 and T4 base of tongue carcinomas based on case descriptions and Magnetic Resonance Images.
  • [MeSH-minor] Data Collection. Glossectomy. Humans. Hypoglossal Nerve / surgery. Laryngectomy. Mandible / surgery. Maxilla / surgery. Medical Futility. Neoplasm Staging. Palate / surgery. Pharyngectomy. Prognosis. Surveys and Questionnaires

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  • (PMID = 19413612.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope; 2006 Jul;116(7):1148-52
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  • All patients had curative surgery as their initial treatment for the primary tumor and neck.
  • The incidence rate of level IV metastasis in patients with ipsilateral nodal metastasis was significantly higher in base of tongue cancer (86% [6 of 7]) compared with tonsillar cancer (34% [20 of 59]) (P=.013).
  • CONCLUSION: These results suggest that elective N0 neck treatment in patients with oropharyngeal SCC, especially base of tongue cancer, should include neck levels II, III, and IV instead of levels I, II, and III.
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Neck Dissection. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 16826050.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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57. Hu YH, Li J: [Clear cell carcinoma of salivary gland: a clinicopathologic study of 10 cases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):54-7
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  • RESULTS: Seven tumors were from palate, one was from base of tongue, one in retromolar region, and one in floor of mouth.
  • Microscopically, the tumors were predominantly composed of trabeculae, cords, nests, solid sheets of clear cells and a few eosinophilic cells, and the two kinds of tumor cells were surrounded by hyalinized stroma.
  • CONCLUSIONS: CCC is a distinctive low grade malignant salivary gland neoplasm, arising mainly in the minor salivary glands, and it may originate from intercalated-duct reserve cells.

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  • (PMID = 15774154.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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58. Sato K, Shimizu S, Oka H, Nakahara K, Utsuki S, Fujii K: Usefulness of transcervical approach for surgical treatment of hypoglossal schwannoma with paraspinal extension: case report. Surg Neurol; 2006 Apr;65(4):397-401, discussion 401
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  • The findings were of a tumor lying in the left hypoglossal canal and paraspinal region and were consistent with hypoglossal schwannoma.
  • Subtotal intracapsular removal of the tumor was performed via transcervical approach.
  • CONCLUSION: The transcervical approach and intracapsular removal of the tumor under electrophysiological monitoring provided for successful minimally invasive surgery in this case of hypoglossal schwannoma.
  • [MeSH-minor] Cervical Vertebrae / anatomy & histology. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Decompression, Surgical / methods. Electric Stimulation. Electromyography. Fasciculation / etiology. Fasciculation / pathology. Fasciculation / physiopathology. Female. Humans. Middle Aged. Monitoring, Physiologic. Neoplasm Recurrence, Local / prevention & control. Skull Base / pathology. Skull Base / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / physiopathology. Skull Base Neoplasms / surgery. Tongue / innervation. Tongue / physiopathology. Treatment Outcome

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  • (PMID = 16531208.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Song M, Chen WK, Guo ZM, Li QL: [Reconstruction with pectoralis major myocutaneous flap for surgical defect in advanced head and neck cancer patients]. Ai Zheng; 2008 Jan;27(1):58-61
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  • Of the 22 patients, 8 had cervical skin defect, 5 had tongue defect, 4 had oropharynx defect, 3 had base of tongue defect, and 2 had hypopharynx defect; 13 had the flap passed through the subclavicular tunnel to the head and neck area, and 9 had the flap transposed over clavicle to the neck.
  • Postoperative complications occurred in 2 (9.1%) patients: 1 had wound hematocele, and 1 had fistula at the base of the tongue.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Oroantral Fistula / etiology. Treatment Outcome

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  • (PMID = 18184465.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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60. Schwartz DL, Hutcheson K, Barringer D, Tucker SL, Kies M, Holsinger FC, Ang KK, Morrison WH, Rosenthal DI, Garden AS, Dong L, Lewin JS: Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Dec 1;78(5):1356-65
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  • Twenty-one (68%) cases were base of tongue and 10 (32%) were tonsil.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20646872.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R21 CA132281; United States / NCI NIH HHS / CA / CA132281
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS575664; NLM/ PMC4034521
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61. Breda E, Fernandes J, Monteiro E: [Transhyoid bucopharyngectomy: a new surgical approach to oropharyngeal tumours]. Rev Laryngol Otol Rhinol (Bord); 2008;129(3):197-200

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  • Infrahyoide muscles dissection from the posterior-inferior surface of the hyoid bone body.
  • Incision of the mouth floor Push down of the tongue to the cervical region.
  • Tumour bloc resection with optimal exposure.
  • MAIN INDICATIONS: T2-3 of tongue base and vallecula, T2-3 of tonsil.
  • CONCLUSION: Transhyoid bucopharyngectomy is an easy and safe procedure for head and neck surgeons, offers an acceptable level of postoperative swallowing and speech function, without the morbidity associated with transmandibular approaches, besides providing a good and wide exposure of the tumour to be removed.
  • [MeSH-minor] Humans. Mouth Floor / surgery. Neck Dissection / methods. Neoplasm Staging. Postoperative Complications / etiology. Tongue Neoplasms / pathology. Tongue Neoplasms / surgery. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / surgery

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  • (PMID = 19694163.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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62. Iyer NG, Kim L, Nixon IJ, Palmer F, Kraus D, Shaha AR, Shah JP, Patel SG, Ganly I: Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx. Arch Otolaryngol Head Neck Surg; 2010 Dec;136(12):1240-7
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  • RESULTS: the most common histologic types were mucoepidermoid carcinoma in 26 patients (39%), adenoid cystic carcinoma in 16 (24%), adenocarcinoma in 16 (24%), and malignant mixed tumor in 7 (10%).
  • The tumors were located in the base of the tongue in 41 patients (61%), soft palate in 20 (30%), and tonsil in 6 (9%).
  • Tumor recurred in 20 patients (34%); 12 of these patients had locoregional failure and 15 developed distant metastases.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasm Recurrence, Local / epidemiology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Salivary Glands, Minor. Survival Rate / trends. Time Factors. United States / epidemiology. Young Adult

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  • (PMID = 21173374.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Nguyen NP, Vos P, Smith HJ, Nguyen PD, Alfieri A, Karlsson U, Dutta S, Lemanski C, Nguyen LM, Sallah S: Concurrent chemoradiation for locally advanced oropharyngeal cancer. Am J Otolaryngol; 2007 Jan-Feb;28(1):3-8
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  • No difference was observed in survival between base of tongue and tonsillar carcinoma (P = .32).
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / therapeutic use. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17162122.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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64. Simon C, Goepfert H, Rosenthal DI, Roberts D, El-Naggar A, Old M, Diaz EM Jr, Myers JN: Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival. Eur Arch Otorhinolaryngol; 2006 Apr;263(4):313-8
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  • [Title] Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival.
  • It is reported that nearly 50% of the neck dissection specimens contain residual viable tumor cells that may indicate partial radiation failure and as a consequence poor survival.
  • In order to address the significance of this finding, we conducted a nonrandomized retrospective study, including 35 patients who underwent definitive radiation therapy followed by either a radical or modified radical (RND/MRND) or a selective neck dissection (SND) for clinically persistent neck disease 6 weeks after completing therapy for stage III/IV SCC of the oropharynx (base of the tongue =15, tonsil =12, soft palate =7 and pharyngeal wall =1).
  • All neck dissection specimens were reviewed according to histological criteria indicating viable residual tumor.
  • The presence of malignant tumor cells in residual disease in the neck correlated with poor disease-specific and overall survival (P =0.03 and P =0.01, respectively).
  • [MeSH-minor] Adult. Aged. Cell Survival. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm, Residual. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16328403.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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65. Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, Hartig GK: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope; 2008 Aug;118(8):1377-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy.
  • OBJECTIVES/HYPOTHESIS: Tumor volume has been demonstrated to play a prognostic role in many head and neck cancers.
  • The purpose of this study was to conduct an institutional review analyzing the correlation between tumor volume and locoregional control of oropharyngeal squamous cell cancer treated with primary radiotherapy.
  • METHODS: Seventy-nine patients from 1991 to 2005 with primary T1 to T4 oropharyngeal squamous cell carcinoma (base of tongue, n = 31; soft palate, n = 1; tonsils, n = 47) were treated with primary radiotherapy.
  • Tumor volumes were measured from pretreatment computerized tomography scans by two observers.
  • Three-dimensional tumor volumes were calculated using a computer digitizer for each computed tomography slice showing the primary lesion.
  • Survival analysis, using the methods of Kaplan and Meier, was performed to assess whether tumor volume, Tumor, Node, Metastasis classification, tumor stage, or location were associated with locoregional failure.
  • RESULTS: Tumor volume did not significantly correlate with locoregional failure (observer 1, P = .6244; observer 2, P = .5612).
  • Nodal status, tumor stage, and location did not significantly correlate with locoregional failure rate.
  • CONCLUSIONS: Tumor volume does not appear to play a significant role in predicting locoregional recurrence for patients with primary squamous cell cancer of the oropharynx treated with primary radiotherapy.
  • [MeSH-minor] Female. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Observer Variation. Prognosis. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18418275.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Zou H, Zhang WF, Han QB, Zhao YF: Salvage reconstruction of extensive recurrent oral cancer defects with the pectoralis major myocutaneous flap. J Oral Maxillofac Surg; 2007 Oct;65(10):1935-9
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  • The reconstruction of the base of the tongue, the floor of the mouth, and the oropharynx emerged as a significant risk factor for flap necrosis on binary logistic regression analysis (P < .05).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 17884518.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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67. Shoushtari AN, Meeneghan M, Treharne GC, Reibel JF, Levine PA, Moskaluk CA, Jameson MJ, Read PW: Clinical nodal staging of T1-2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation. Cancer J; 2010 May-Jun;16(3):284-7
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  • Patients with a history of prior head and neck cancer, synchronous cancers, base of tongue or soft palate invasion, or distant metastases at diagnosis were excluded.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Lymphatic Metastasis / radiotherapy. Neoplasm Proteins / metabolism. Tonsillar Neoplasms / pathology

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  • (PMID = 20526108.001).
  • [ISSN] 1540-336X
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK067629
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / P16 protein, human
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68. Patterson JM, Hildreth A, Wilson JA: Measuring edema in irradiated head and neck cancer patients. Ann Otol Rhinol Laryngol; 2007 Aug;116(8):559-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lower levels of agreement were found for the tongue base, valleculae, pharyngeal walls, and anterior commissure.
  • [MeSH-major] Edema / diagnosis. Laryngeal Edema / diagnosis. Otorhinolaryngologic Neoplasms / radiotherapy. Pharyngeal Diseases / diagnosis. Radiation Injuries / diagnosis
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Follow-Up Studies. Humans. Laryngoscopy. Larynx / radiation effects. Male. Middle Aged. Neoplasm Staging. Observer Variation. Pharynx / radiation effects. Prospective Studies. Radioisotope Teletherapy. Reference Values. Video Recording

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  • (PMID = 17847721.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Lim YC, Hong HJ, Baek SJ, Park JH, Kim GE, Lee CG, Lew DH, Lee WJ, Choi EC: Combined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases. Int J Oral Maxillofac Surg; 2008 Dec;37(12):1099-105
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  • The DSSR of the soft palate or posterior pharyngeal wall, tonsillar area, and base of tongue were 80%, 62%, and 51%, respectively (P<0.05).
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Korea. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck / pathology. Neck Dissection. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Palate, Soft / radiation effects. Palate, Soft / surgery. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy. Survival Rate. Tongue Neoplasms / radiotherapy. Tongue Neoplasms / surgery. Tonsillar Neoplasms / radiotherapy. Tonsillar Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18722091.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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70. Milano MT, Vokes EE, Kao J, Jackson W, List MA, Stenson KM, Witt ME, Dekker A, MacCracken E, Garofalo MC, Chmura SJ, Weichselbaum RR, Haraf DJ: Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol; 2006 May;28(5):1141-51
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  • Sixty-nine patients with Stage IV head and neck cancer (and stage III base of tongue and hypopharynx) enrolled in a Phase II study of definitive chemoradiation; 20 received all or part of their radiation with IMRT.
  • [MeSH-minor] Adult. Aged. Biopsy. Carboplatin / administration & dosage. Humans. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Radiotherapy / adverse effects. Radiotherapy Dosage. Survival Analysis

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  • (PMID = 16596230.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA14599; United States / NIDCR NIH HHS / DE / P50 DE11921-04
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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71. Seethala RR, Johnson JT, Barnes EL, Myers EN: Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience. Arch Otolaryngol Head Neck Surg; 2010 Apr;136(4):385-92
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  • Four of 24 patients (17%) had regional lymph node metastases, 3 with carcinomas of the base of the tongue.
  • CONCLUSIONS: Diagnosis of PLGA remains a challenge.
  • Extrapalatal carcinomas appear to behave in a more aggressive fashion than those of the palate, and cancer arising from the base of the tongue frequently metastasizes to the cervical lymph nodes, suggesting a role for neck dissection in these patients.
  • [MeSH-major] Adenocarcinoma / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 20403856.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Rapidis AD, Trichas M, Stavrinidis E, Roupakia A, Ioannidou G, Kritselis G, Liossi P, Giannakouras G, Douzinas EE, Katsilieris I: Induction chemotherapy followed by concurrent chemoradiation in advanced squamous cell carcinoma of the head and neck: final results from a phase II study with docetaxel, cisplatin and 5-fluorouracil with a four-year follow-up. Oral Oncol; 2006 Aug;42(7):675-84
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  • The site of the primary tumors was the anterior mouth in 9 pts, base of tongue and oropharynx in 12, middle third of the face in 8 and larynx in 13.
  • [MeSH-minor] Adult. Age Distribution. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Male. Middle Aged. Neoplasm Staging. Radiation Injuries / etiology. Radiotherapy / adverse effects. Remission Induction. Sex Distribution. Survival Analysis. Taxoids / administration & dosage. Taxoids / adverse effects. Treatment Outcome

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  • (PMID = 16731029.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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73. Yang S, Zhang J, Chen X, Wang L, Xie F: Clear cell carcinoma, not otherwise specified, of salivary glands: a clinicopathologic study of 4 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):712-20
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  • Clear cell carcinoma, not otherwise specified (CCC-NOS), is a recently described rare malignant salivary neoplasm.
  • The results were then analyzed collectively with the approximate 60 cases of CCC-NOS reported in the English-language literature to define the characteristics of this unusual neoplasm.
  • Combining our cases with those in the literature, a total of 66 cases, confirms that CCC-NOS is a low-grade malignant neoplasm with distinctive clinical and pathologic features.
  • It arises primarily in the minor salivary glands (91% of cases), particularly in the palate or base of tongue, and usually occurs in patients >30 years of age (mean 54.2 years) with a female-to-male ratio of 1.4:1; 12.3% of patients experience local recurrences, 19.3% develop positive regional lymph nodes, 8.8% have distant metastases, and 3.5% die of the disease.
  • Immunohistochemical study focusing on tumor differentiation was performed for our cases, and the findings support the concept that CCC-NOS is of ductal epithelial origin without myoepithelial cell participation.

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  • (PMID = 18602286.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 43
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74. Perkins JA, Inglis AF, Sie KC, Manning SC: Recurrent thyroglossal duct cysts: a 23-year experience and a new method for management. Ann Otol Rhinol Laryngol; 2006 Nov;115(11):850-6
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  • Successful procedures used for secondary TGDC management included central neck dissection with directed base of tongue (BOT) excision in 6 of 9 patients (67%), secondary Sistrunk operation with limited BOT resection in 12 of 27 patients (44%), revision Sistrunk operation with BOT dissection in 7 of 11 patients (64%), and suture-guided transhyoid pharyngotomy in 8 of 8 patients (100%).
  • The factors associated with TGDC recurrence were inaccurate initial diagnosis (17 of 34 or 50%), infection (5 of 34 or 15%), unusual TGDC presentation (5 of 34 or 15%), and lack of BOT musculature removal (7 of 34 or 20%).
  • [MeSH-major] Neck Dissection / methods. Neoplasm Recurrence, Local / surgery. Pharynx / surgery. Thyroglossal Cyst / surgery

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  • (PMID = 17165669.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Jo VY, Mills SE, Stoler MH, Stelow EB: Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol; 2009 Nov;33(11):1720-4
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  • As with other HPV-associated SCCs of the upper aerodigestive tract, the majority of HPV-associated papillary SCCs are oropharyngeal (base of tongue and palatine tonsils), although both sinonasal and laryngeal tumors were also associated with infection (67% and 33% of cases, respectively).
  • [MeSH-minor] Adult. Aged. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. DNA, Viral / analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 19745700.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
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76. Weinstein GS, Quon H, O'Malley BW Jr, Kim GG, Cohen MA: Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial. Laryngoscope; 2010 Sep;120(9):1749-55
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  • There were 29 males and two females, with ages ranging from 36 to 76 years (median = 55 years) with one palate, one lateral wall, 17 tonsil, 11 base of tongue, and one vallecula primary tumor classified as follows: T1 (n = 9, 29%), T2 (n = 15, 48.4%), T3 (n = 7, 22.6%), N0 (n = 6, 19.4%), N1 (n = 15, 48.4%), N2b (n = 10, 32.3%), and N2c (n = 1, 3.2%).
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant

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  • (PMID = 20717944.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Pedruzzi PA, Kowalski LP, Nishimoto IN, Oliveira BV, Tironi F, Ramos GH: Analysis of prognostic factors in patients with oropharyngeal squamous cell carcinoma treated with radiotherapy alone or in combination with systemic chemotherapy. Arch Otolaryngol Head Neck Surg; 2008 Nov;134(11):1196-204
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  • RESULTS: Most tumors were located at the tonsil (46.8%) or base of the tongue (28.0%) and were at clinical stage III or IV (92.8%).
  • Treatment response was associated with Zubrod scale score, weight loss, number of comorbidities, symptom-severity and Piccirillo stages, hemoglobin level, tumor site, macroscopic appearance of the tumor, and clinical stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Tongue Neoplasms / drug therapy. Tongue Neoplasms / mortality. Tongue Neoplasms / pathology. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / radiotherapy

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  • (PMID = 19015451.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Smith JE, Suh JD, Erman A, Nabili V, Chhetri DK, Blackwell KE: Risk factors predicting aspiration after free flap reconstruction of oral cavity and oropharyngeal defects. Arch Otolaryngol Head Neck Surg; 2008 Nov;134(11):1205-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aspiration risk factors analyzed included age; sex; tumor T and N stage; comorbidity level (American Society of Anesthesiologists classification); preoperative swallowing function; history of tobacco use; surgical approach used for tumor resection; defect classification; type of free flap; history of radiation therapy, surgery, and/or chemotherapy; and surgical defect classification.
  • RESULTS: The following risk factors were significant predictors of postoperative aspiration on univariate analysis: prior radiation therapy (P < .001), tongue base resection classification (P = .001), tumor N stage (P < .001), hypoglossal nerve sacrifice (P = .004), and presence of a mandibular osteotomy (P = .01).
  • On multivariate analysis, only a history of radiation therapy (P = .002) and tongue base resection (P = .008) remained statistically significant predictors of aspiration.
  • CONCLUSION: Patients with resection of more than half of the tongue base and patients with a history of radiation therapy are at high risk of having early postoperative aspiration after free flap reconstruction.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Deglutition Disorders / etiology. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 19015452.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Badakhshi H, Marnitz S, Scherer H, Budach V, Haisch A: [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences]. HNO; 2008 Mar;56(3):328-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIAL AND METHODS: A 44 year old woman with the diagnosis of adenoid cystic carcinoma of the oropharynx and simultaneous pulmonary metastases received a mixed beam photon radiotherapy and a neutron boost.
  • A local recurrence in the base of tongue and floor of mouth was histologically confirmed.
  • Under general anaesthesia, eight needles were implanted into the palpable tumour.
  • On the basis of a pretreatment MRI, a single dose of 5 Gy encompassing the palpable tumour was given to a total dose of 15 Gy.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Adenoid Cystic / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Oropharyngeal Neoplasms / radiotherapy

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  • (PMID = 18288466.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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80. Walvekar RR, Li RJ, Gooding WE, Gibson MK, Heron D, Johnson JT, Ferris RL: Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx. Laryngoscope; 2008 Dec;118(12):2129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Forty-nine limited oropharyngeal squamous cell cancers of the tonsil, tongue base, or posterior pharyngeal wall-treated surgically were identified.
  • CONCLUSIONS: Surgical staging identifies patients in whom intensification of treatment with chemotherapy can be most appropriately applied, and enables de-intensification of therapy in pathology confirmed stage I/II disease.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant

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  • (PMID = 18948826.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Zhao Y, Liu YH, Mei JY, Lu DH, Wu J, Ma YX, Yang KL: [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jul;45(7):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root].
  • OBJECTIVE: To investigate the surgical technique which could preserve the swallowing and laryngeal function effectively in the malignant head and neck tumors involving the tongue root.
  • METHODS: From January 2003 to December 2008, 31 cases of malignant head and neck tumors involving the tongue base had been treated in this hospital were retrospectively analyzed.
  • There were 27 males and 4 females in which 9 cases of primary malignant tumor were from the base of tongue; 3 cases were from the tonsil, 11 cases were from supraglottic laryngeal carcinoma and 8 cases were from hypopharyngeal carcinoma.
  • Preserved the lingual artery of the reserved side and the normal tissue of the root of tongue according to the clinical anatomy of lingual artery during the operation.
  • RESULTS: In this group, residual tongue necrosis did not occurred.
  • Two with root of tongue cancer and 1 with tonsil cancer had postoperative infection and healed in 2 weeks.
  • CONCLUSIONS: In the surgical treatments of the malignant head and neck tumors involving the base of tongue, the excisions and reconstructions of the primary tumor and the involved tongue base according to the clinical anatomy of lingual artery and the protection mechanisms of laryngeal function during the operation was one of the most effective technique to preserve the swallowing and laryngeal function.
  • [MeSH-major] Glossectomy / methods. Head and Neck Neoplasms / surgery. Tongue Neoplasms / surgery

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  • (PMID = 21055059.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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82. Grant DG, Hinni ML, Salassa JR, Perry WC, Hayden RE, Casler JD: Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1225-30

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  • The primary tumor sites were the tonsil (n = 28 [41%]), tongue base (n = 28 [41%]), pharyngeal wall (n = 8 [12%]), soft palate (n = 4 [6%]), and vallecula (n = 1 [1%]).
  • [MeSH-minor] Enteral Nutrition. Female. Humans. Laryngeal Neoplasms. Length of Stay. Male. Neck Dissection. Neoplasm Recurrence, Local. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Tracheostomy

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  • (PMID = 20026820.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A: Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jun;109(6):e67-71
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  • Microscopically, the tumor shows cystic degeneration of the neoplastic epithelium, producing a prominent alveolar pattern and pseudoglandular structures with acantholytic cells.
  • This case concerns a 72-year-old woman who presented with the chief complaint of burning tongue and soreness of the lips.
  • Clinical examination revealed an ulcerated and elevated mass on the edentulous left maxillary ridge, beneath the base of a partial denture.
  • An incisional biopsy rendered the diagnosis of adenoid squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20451835.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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84. Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A: Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys; 2009 Aug 1;74(5):1365-70

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  • METHODS AND MATERIALS: Between August 2003 and June 2007, 20 patients who presented with squamous cell carcinoma of the tonsil, without involvement of the base of the tongue or midline soft palate, and with Stage N1-N2b disease were prospectively treated with radiotherapy to the primary site and ipsilateral neck.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / radiotherapy. Male. Middle Aged. Neck. Neoplasm Staging. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Survival Rate. Treatment Outcome

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  • (PMID = 19168295.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Ming W, Hua Q, Zhan H: [Pharyngocutaneous fistula following total laryngectomy in patients with advanced stage hypopharyngeal or laryngeal carcinomas]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jun;22(12):542-3
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  • CONCLUSION: PCF is often situated in tongue base and post-superior of trachea stoma.
  • Tumor locations and postoperative fever are important predisposition.
  • [MeSH-minor] Adult. Aged. Female. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Incidence. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18800680.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Jäckel MC, Heyny-von Haussen R: [Dysphagia and dysarthria due to the long-term growth of a tongue base tumor]. HNO; 2006 May;54(5):382-4
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  • [Title] [Dysphagia and dysarthria due to the long-term growth of a tongue base tumor].
  • [MeSH-major] Adenocarcinoma / pathology. Deglutition Disorders / etiology. Dysarthria / etiology. Tongue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cell Division / physiology. Chronic Disease. Female. Humans. Lymphatic Metastasis / pathology. Microsurgery. Middle Aged. Neck Dissection. Neoplasm Staging. Surgical Flaps. Tomography, X-Ray Computed. Tongue / pathology

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  • (PMID = 16477463.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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87. Patel NN, Upile T: Re: A technique for trans-lingual biopsy of the tongue base. Clin Otolaryngol; 2008 Aug;33(4):375-6
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  • [Title] Re: A technique for trans-lingual biopsy of the tongue base.
  • [MeSH-major] Biopsy / methods. Tongue / pathology
  • [MeSH-minor] Humans. Neoplasm Seeding

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  • [CommentOn] Clin Otolaryngol. 2007 Dec;32(6):504 [18076454.001]
  • (PMID = 18983358.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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88. Zacharia TT, Som PM: Multiple adult rhabdomyomas of the oropharynx, base of the tongue, and floor of the mouth: magnetic resonance findings. Arch Otolaryngol Head Neck Surg; 2008 Aug;134(8):892-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple adult rhabdomyomas of the oropharynx, base of the tongue, and floor of the mouth: magnetic resonance findings.
  • [MeSH-major] Magnetic Resonance Imaging. Mouth Floor. Mouth Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Oropharyngeal Neoplasms / diagnosis. Rhabdomyosarcoma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Humans. Male. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18711066.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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