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1. Hirunpat S, Jongsatitpaiboon J, Angunsri N, Chowchuvech V: When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma? Asian Pac J Cancer Prev; 2007 Apr-Jun;8(2):310-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma?
  • BACKGROUND AND PURPOSE: According to the American Joint Committee on Cancer (AJCC) cancer staging criteria (6th edition), cross-sectional imaging for base of tongue carcinoma is recommended when the deep tissue extent of a primary tumor is in question.
  • The aim of this study was to establish which group of patients MRI might most benefit from accurate clinical staging of base of tongue carcinomas.
  • PATIENTS AND METHODS: The clinical stagings of 33 patients with pathologically proven squamous cell carcinomas of the base of tongue were performed by two otorhinolaryngologic surgeons.
  • CONCLUSION: MRI should be recommended in base of tongue carcinoma whenever clinical examination suggests overall stage groupings II, III or tumor stage T3.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Reproducibility of Results

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  • (PMID = 17696753.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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2. Díaz Molina JP, Rodrigo JP, Llorente JL, Alvarez Marcos C, Moreno C, Suárez C: [Oncologic and functional results of surgical treatment for base of tongue carcinomas]. Acta Otorrinolaringol Esp; 2010 Sep-Oct;61(5):351-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Oncologic and functional results of surgical treatment for base of tongue carcinomas].
  • [Transliterated title] Resultados oncológicos y funcionales del tratamiento quirúrgico de los carcinomas de base de lengua.
  • INTRODUCTION AND OBJECTIVES: Squamous cell carcinomas at the base of the tongue are usually diagnosed at advanced stages, and their optimal treatment has not been established.
  • The aim of this study was to describe the functional and oncological outcomes of patients with base of tongue carcinomas treated with surgery.
  • MATERIALS AND METHODS: A retrospective study on 132 patients with base of tongue carcinoma surgically treated in our hospital between 1990 and 2007 was carried out.
  • CONCLUSIONS: The prognosis of squamous cell carcinomas of the base of the tongue is poor, especially in advanced stages.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Recovery of Function. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier España, S.L. All rights reserved.
  • (PMID = 20684822.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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3. Bakshi J, Panda NK, Ghoshal S, Nehru VI: Survival patterns in patients with carcinoma base of tongue treated with external beam irradiation and salvage surgery. Indian J Otolaryngol Head Neck Surg; 2010 Jun;62(2):142-7

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  • [Title] Survival patterns in patients with carcinoma base of tongue treated with external beam irradiation and salvage surgery.
  • OBJECTIVE: The current study was designed to assess the treatment results and survival in the patients with carcinoma of base of tongue that were treated with primary radiotherapy, radiotherapy with chemotherapy and salvage surgery when indicated.
  • DESIGN: A prospective study was carried out in 78 cases of carcinoma of the base of tongue between 1995 and 1999.
  • Radiotherapy in the dose of 60 Gy was given primarily to the patients with stage III tongue base cancer.
  • CONCLUSIONS: External beam radiotherapy with salvage surgery results in satisfactory local and regional control in stage III and IV carcinoma base of tongue.

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  • (PMID = 23120701.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450302
  • [Keywords] NOTNLM ; Base of tongue / Radiation therapy / Salvage surgery / Survival
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4. Uzochukwu NO, Shrier DA, Lapoint RJ: Clear cell carcinoma of the base of the tongue: MR imaging findings. AJNR Am J Neuroradiol; 2007 Jan;28(1):127-8
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  • [Title] Clear cell carcinoma of the base of the tongue: MR imaging findings.
  • Clear cell carcinoma of the base of the tongue is a rare minor salivary gland neoplasm, and to our knowledge, the MR imaging appearance of this entity has not been described.
  • We present the MR imaging findings in such a case and review the differential diagnosis for tongue base masses in an adult.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Magnetic Resonance Imaging. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Deglutition Disorders / etiology. Diagnosis, Differential. Female. Humans. Laryngoscopy. Middle Aged. Tongue / pathology. Tongue / surgery

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  • (PMID = 17213438.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Bell D, Zhao YJ, Rao PH, Weber RS, El-Naggar AK: Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue. Head Neck Pathol; 2007 Dec;1(2):165-8
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  • [Title] Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.
  • We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY).

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  • (PMID = 20614269.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807514
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Comparative genomic hybridizations / Cytogenetic / Spectral karyotyping / Translocations
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6. Peters P, Repanos C, Earnshaw J, Stark P, Burmeister B, McGuire L, Jeavons S, Coman A M WB: Epithelial-myoepithelial carcinoma of the tongue base: a case for the case-report and review of the literature. Head Neck Oncol; 2010;2:4
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  • [Title] Epithelial-myoepithelial carcinoma of the tongue base: a case for the case-report and review of the literature.
  • A 60 year old lady was referred to the Princess Alexandra Hospital (Brisbane, Queensland, Australia) tertiary Otolaryngology, Head and Neck Unit from a peripheral hospital for investigation and management of a tumour at the base of the tongue.
  • Biopsy of the tumour revealed it to be an epithelial-myoepithelial carcinoma of the base of the tongue.
  • We present a case where such a policy would have denied patient choice and possibly led to detrimental treatment.We review the world literature of tongue base epithelial-myoepithelial carcinoma of the tongue.
  • [MeSH-major] Tongue Neoplasms / pathology
  • [MeSH-minor] Biopsy. Epithelial-Mesenchymal Transition. Female. Humans. Middle Aged. Tomography, X-Ray Computed. Tongue / pathology

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  • (PMID = 20181065.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2830934
  • [General-notes] NLM/ Original DateCompleted: 20100629
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7. Camp AA, Fundakowski C, Petruzzelli GJ, Emami B: Functional and oncologic results following transoral laser microsurgical excision of base of tongue carcinoma. Otolaryngol Head Neck Surg; 2009 Jul;141(1):66-9
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  • [Title] Functional and oncologic results following transoral laser microsurgical excision of base of tongue carcinoma.
  • OBJECTIVE: The study objective was to determine survival and functional results in patients who underwent transoral laser excision of base of tongue squamous cell carcinoma.
  • SUBJECTS AND METHODS: Patients with biopsy-proven base of tongue squamous cell carcinoma primarily treated with transoral laser excision and followed for at least 24 months were included.
  • RESULTS: Of the 71 patients treated, one (1.4%), nine (12.7%), seven (9.9%), and 54 (76.1%) were stage I, II, III, and IV, respectively, at diagnosis.
  • CONCLUSION: Transoral laser excision offers an acceptable treatment approach in terms of survival and quality of life for patients with base of tongue squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laser Therapy / methods. Tongue Neoplasms / surgery

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  • (PMID = 19559960.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Anker CJ, Wang B, Tobler M, Chapek J, Shrieve DC, Hitchcock YJ, Salter BJ: Evaluation of fluence-smoothing feature for three IMRT planning systems. J Appl Clin Med Phys; 2010 Apr 16;11(2):3035
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  • We evaluated four cases treated with IMRT in our clinic: sinonasal carcinoma (SNC), glioblastoma multiforme (GBM), base of tongue carcinoma (BOT), and prostate carcinoma (PST).

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  • (PMID = 20592692.001).
  • [ISSN] 1526-9914
  • [Journal-full-title] Journal of applied clinical medical physics
  • [ISO-abbreviation] J Appl Clin Med Phys
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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9. van Lierop AC, Basson O, Fagan JJ: Is total glossectomy for advanced carcinoma of the tongue justified? S Afr J Surg; 2008 Feb;46(1):22-5
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  • [Title] Is total glossectomy for advanced carcinoma of the tongue justified?
  • Total glossectomy (with or without total laryngectomy) followed by postoperative radiotherapy remains the principal treatment method for advanced base of tongue carcinoma.
  • METHODS: We did a retrospective chart review of all patients at Groote Schuur Hospital, Cape Town, who had undergone total glossectomy, with or without total laryngectomy, for stage IV squamous cell carcinoma (SCC) of the tongue between 1998 and 2004.
  • CONCLUSION: Advanced SCC of the tongue is a devastating disease causing severe pain and disorders of speech and swallowing.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Glossectomy. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 18468419.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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10. Kreeft A, Tan IB, van den Brekel MW, Hilgers FJ, Balm AJ: The surgical dilemma of 'functional inoperability' in oral and oropharyngeal cancer: current consensus on operability with regard to functional results. Clin Otolaryngol; 2009 Apr;34(2):140-6
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  • The current survey aims to define the borders of functional inoperability in oral and oropharyngeal carcinoma and evaluate its current use by obtaining opinions from the experts in the field.
  • DESIGN: A web base survey.
  • There is no absolute consensus about the functional outcome after certain surgical procedures, namely: bilateral maxillectomy, resection of a tonsil and resection of base of tongue carcinoma including removal of the vallecula and epiglottis, and total soft palate resection.
  • Disagreement of operability is also observed for T3 and T4 base of tongue carcinomas based on case descriptions and Magnetic Resonance Images.
  • [MeSH-minor] Data Collection. Glossectomy. Humans. Hypoglossal Nerve / surgery. Laryngectomy. Mandible / surgery. Maxilla / surgery. Medical Futility. Neoplasm Staging. Palate / surgery. Pharyngectomy. Prognosis. Surveys and Questionnaires

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  • (PMID = 19413612.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Karakoyun-Celik O, Norris CM Jr, Tishler R, Mahadevan A, Clark JR, Goldberg S, Devlin P, Busse PM: Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base. Head Neck; 2005 May;27(5):353-61
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  • [Title] Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base.
  • BACKGROUND: The purpose of this study was to examine the long-term outcome of a cohort of patients with unresected base of tongue carcinoma who received interstitial brachytherapy after comprehensive external beam radiation therapy.
  • METHODS: Between 1983 and 2000, 122 patients with primary or recurrent squamous cell carcinoma of the oropharynx or oral cavity received interstitial brachytherapy as part of their overall management.
  • Forty patients had primary, unresected carcinoma of the base of tongue and are the subjects of this analysis.
  • The oropharynx, bilateral neck, and supraclavicular fossae were comprehensively irradiated, and the tongue base received a median external beam dose of 61.2 Gy (50-72 Gy).
  • The long-term data presented here support an approach of treating advanced tongue base lesions that includes interstitial brachytherapy as part of the overall management plan.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Squamous Cell / therapy. Tongue Neoplasms / therapy

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15726587.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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12. Lin CX, Li GF: [Application of parasymphyseal mandible osteotomy combined with set-back tongue flap in treatment of tongue base carcinoma]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2008 Mar;37(2):198-202
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  • [Title] [Application of parasymphyseal mandible osteotomy combined with set-back tongue flap in treatment of tongue base carcinoma].
  • OBJECTIVE: To evaluate the efficacy of the approach of parasymphyseal mandible osteotomy combined with set-back tongue flap in treatment of tongue base carcinoma.
  • METHODS: In total 18 patients with cancer of tongue base, 13 were males and 5 females aged of 30 to 65 y (average 52.9 y).
  • Eighteen patients were treated by parasymphyseal mandible osteotomy combined with set-back tongue flap in our hospital from June 2001 to June 2006.
  • CONCLUSION: Parasymphyseal mandible osteotomy provides good exposure, and set-back tongue flap to reconstruction of the base of tongue can partially restore the function of tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mandible / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Osteotomy. Tongue / surgery

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  • (PMID = 18422283.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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13. Jones AS, Rafferty M, Fenton JE, Jones TM, Husband DJ: Treatment of squamous cell carcinoma of the tongue base: irradiation, surgery, or palliation? Ann Otol Rhinol Laryngol; 2007 Feb;116(2):92-9
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  • [Title] Treatment of squamous cell carcinoma of the tongue base: irradiation, surgery, or palliation?
  • OBJECTIVES: Squamous cell carcinoma of the tongue base has a poor prognosis, and treatment is accompanied by a number of major problems.
  • METHODS: One hundred sixty-five patients with squamous cell carcinoma of the tongue base were identified on our database.
  • CONCLUSIONS: In terms of observed survival, treating tongue base squamous cell carcinoma that is locally advanced (T3-4) at presentation offers no survival advantage over palliation alone.
  • [MeSH-major] Carcinoma, Squamous Cell. Decision Making. Palliative Care / methods. Tongue Neoplasms

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  • (PMID = 17388231.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Grant DG, Salassa JR, Hinni ML, Pearson BW, Perry WC: Carcinoma of the tongue base treated by transoral laser microsurgery, part two: Persistent, recurrent and second primary tumors. Laryngoscope; 2006 Dec;116(12):2156-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the tongue base treated by transoral laser microsurgery, part two: Persistent, recurrent and second primary tumors.
  • OBJECTIVES: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of persistent, recurrent, and second primary squamous cell carcinoma of the tongue base.
  • METHODS: Twenty-five patients with persistent, recurrent, or second primary squamous cell carcinoma of the tongue base were treated with TLM between 1997 and 2005.
  • CONCLUSIONS: Transoral laser surgery is a rational and effective treatment in appropriately selected patients with persistent, recurrent, or second primary tongue base cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laser Therapy. Microsurgery / methods. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / surgery. Tongue Neoplasms / surgery

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  • (PMID = 17146389.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Grant DG, Salassa JR, Hinni ML, Pearson BW, Perry WC: Carcinoma of the tongue base treated by transoral laser microsurgery, part one: Untreated tumors, a prospective analysis of oncologic and functional outcomes. Laryngoscope; 2006 Dec;116(12):2150-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the tongue base treated by transoral laser microsurgery, part one: Untreated tumors, a prospective analysis of oncologic and functional outcomes.
  • OBJECTIVES: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the management of untreated primary carcinoma of the tongue base.
  • METHODS: Fifty-nine patients with pathologically confirmed squamous cell carcinoma of the tongue base were treated with TLM between 1997 and 2005.
  • CONCLUSIONS: Transoral laser surgery is a safe and effective treatment for select early and advanced previously untreated squamous cell cancer of the tongue base.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laser Therapy. Microsurgery / methods. Tongue Neoplasms / surgery

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  • (PMID = 17146388.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Murinello A, Damásio A, Figueiredo AM, Netta J, Carvalho A, Mato AA, Murillo MJ, Albuquerque A: Watermelon stomach, hemorrhagic pericarditis, small cell carcinoma of the lung and synchronous squamous cell carcinoma of the tongue base. Rev Port Pneumol; 2010 Jul-Aug;16(4):659-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Watermelon stomach, hemorrhagic pericarditis, small cell carcinoma of the lung and synchronous squamous cell carcinoma of the tongue base.
  • Based on a case of gastric antral vascular ectasia (watermelon stomach) that was associated with hemorrhagic pericarditis, small cell lung carcinoma with mediastinal lymph node metastases and a synchronous squamous cell carcinoma of the base of the tongue, the authors made a review of the clinical, endoscopic and histopathological aspects of this type of gastropathy, and its association with other diseases, and of the results of its endoscopic therapy.
  • The causes of hemorrhagic pericarditis are considered, emphasizing the necessity to know if the effusion has a malignant etiology.
  • To the best of our knowledge the association of watermelon stomach to small cell lung carcinoma and squamous cell carcinoma of the base of the tongue has not yet been described.
  • Extensive metastases to mediastal lymph nodes are common to small cell lung carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Gastric Antral Vascular Ectasia / complications. Hemorrhage / complications. Lung Neoplasms / complications. Neoplasms, Multiple Primary / complications. Pericarditis / complications. Small Cell Lung Carcinoma / complications. Tongue Neoplasms / complications


17. Konsulov SS: Carcinoma of the tongue base. Folia Med (Plovdiv); 2005;47(3-4):24-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the tongue base.
  • AIM: This study reports the results of surgical treatment of patients with carcinoma of the base of tongue-supraglottic complex.
  • The base of the tongue, the epiglottic valleculae, preepiglottic space and supraglottic part of the larynx develop from one central region.
  • The proper term to refer to these structures is tongue base-supraglottic complex.
  • Carcinoma of this complex is a challenge for the surgeons working in the field of head and neck surgery.
  • METHODS: Patients with squamous-cell carcinoma of the tongue base present usually in advanced stage of the disease.
  • All patients underwent supraglottic laryngectomy through suprahyoid pharyngectomy and extended resection of the tongue base that allowed sufficient visualization of the tumor.
  • RESULTS: Twenty-eight patients with carcinoma of the tongue base-supraglottic complex were treated in the Department of Ear, Nose and Throat Diseases of the Medical University Plovdiv between 2001 and 2004.
  • CONCLUSIONS: The supraglottic laryngectomy with suprahyoid pharyngectomy provides good exposure of the tumor in the area of the tongue base-supraglottic complex allowing thorough resection of the tumor and avoiding the functional and cosmetic defects characteristic of the combined method (mandibulotomy).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16761390.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bulgaria
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18. Hans S, Chauvet D, Sadoughi B, Brasnu DF: Cardiac metastasis after squamous cell carcinoma of the base of tongue. Am J Otolaryngol; 2009 May-Jun;30(3):206-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac metastasis after squamous cell carcinoma of the base of tongue.
  • We report a case of squamous cell carcinoma of the base of tongue secondarily complicated with cardiac metastasis 6 months after surgical treatment resulted in successful local control.
  • CONCLUSIONS: Cardiac metastasis should be suspected when new cardiovascular symptoms are observed in patients with a history of head and neck neoplasm.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Heart Neoplasms / secondary. Tongue Neoplasms / pathology

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  • (PMID = 19410127.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Mulwafu W, Fagan JJ, Lentin R: Suprahyoid approach to base-of-tongue squamous cell carcinoma. S Afr J Surg; 2006 Aug;44(3):120, 122-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suprahyoid approach to base-of-tongue squamous cell carcinoma.
  • OBJECTIVE: To evaluate the suprahyoid approach to treatment of squamous cell carcinoma of the base of the tongue at Groote Schuur Hospital between 1999 and 2004.
  • DESIGN AND METHOD: Retrospective analysis was done of patients with base-of-tongue squamous cell carcinoma treated using the suprahyoid approach.
  • RESULTS: Seventeen patients underwent treatment for base-of-tongue squamous cell carcinoma utilising the suprahyoid approach.
  • CONCLUSION: The suprahyoid approach to treatment of base-of-tongue squamous cell carcinoma provides good exposure, local tumour control and excellent functional outcome.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hyoid Bone. Tongue / surgery. Tongue Neoplasms / surgery

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  • (PMID = 16958238.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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20. Kljajić V, Jović R, Canji K, Nikolin B, Gavrilović M: [Surgical techniques and outcomes in the treatment of malignant tongue base tumors]. Med Pregl; 2007 Jan-Feb;60(1-2):49-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical techniques and outcomes in the treatment of malignant tongue base tumors].
  • INTRODUCTION: Prognosis of patients with malignant tongue base tumors is poor.
  • The aim of this investigation was to compare different treatment modalities in patients with malignant tongue base tumors.
  • Planocellular cancer was diagnosed in 79/82 patients, and the remaining (3182) had transitional cell carcinoma.
  • Tongue base resection only was performed in 12 patients, tongue base resection with epiglottectomy in 20, tongue base resection with supraglottic laryngectomy in 13 and tongue base resection with total laryngectomy in 5 patients.
  • Five-year survival after combined surgical and radiation therapy was 35% CONCLUSION: Development of tongue base carcinoma is strongly associated with alcohol and tobacco consumption.
  • However, combined therapy is the therapy of choice in cases with tongue base carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Carcinoma, Transitional Cell / surgery. Tongue Neoplasms / surgery

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  • (PMID = 17853711.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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21. Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW, Werning JW, Villaret DB: Definitive radiotherapy for squamous cell carcinoma of the base of tongue. Am J Clin Oncol; 2006 Feb;29(1):32-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive radiotherapy for squamous cell carcinoma of the base of tongue.
  • OBJECTIVE: To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer.
  • METHODS: There were 333 patients with squamous cell carcinoma of the base of tongue treated with definitive RT and had follow-up from 0.2 to 26.2 years.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Retrospective Studies. Treatment Outcome

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  • (PMID = 16462500.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Budrukkar A, Shahid T, Murthy V, Hussain T, Mulherkar R, Vundinti BR, Deshpande M, Sengar M, Laskar SG, Agarwal JP: Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature. Head Neck; 2010 Oct;32(10):1422-7
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  • [Title] Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: case report and review of literature.
  • BACKGROUND: Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies.
  • Solid tumors in the head and neck region, especially in the tongue, are rarely observed.
  • METHODS: We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Fanconi Anemia / diagnosis. Tongue Neoplasms / radiotherapy

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  • [Copyright] © 2009 Wiley Periodicals, Inc.
  • (PMID = 19672872.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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23. Henstrom DK, Moore EJ, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1231-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral resection for squamous cell carcinoma of the base of the tongue.
  • OBJECTIVE: To review the oncologic and functional outcomes of patients with squamous cell carcinoma of the base of the tongue who underwent transoral tumor resection and neck dissection with or without postoperative adjuvant therapy.
  • PATIENTS: All patients undergoing transoral resection of squamous cell carcinoma on the base of the tongue as part of their primary treatment from January 1, 1996, through January 31, 2005.
  • CONCLUSIONS: Transoral resection of squamous cell carcinoma of the base of the tongue with postoperative adjuvant therapy provided excellent local and regional control and minimized morbidity.
  • Transoral resection is a reasonable treatment option for patients with oropharyngeal squamous cell carcinoma, resulting in very low overall loss of organ function in properly selected patients.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Enteral Nutrition. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 20026821.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Wakisaka N, Murono S, Minato H, Furukawa M, Yoshizaki T: A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base. Auris Nasus Larynx; 2006 Dec;33(4):487-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base.
  • Although the association between undifferentiated nasopharyngeal carcinoma and Epstein-Barr virus (EBV) is consistent, there is conflicting evidence as to the association of EBV with undifferentiated carcinomas outside the nasopharynx.
  • Here, we report on a case of undifferentiated carcinoma of the tongue base.
  • A 71-year-old male, who had been treated with irradiation for primary unknown right neck metastatic EBV-positive undifferentiated carcinoma 9 years previously, was referred to our clinic with masses at the tongue base and right neck.
  • The lesion at the tongue base was revealed to be an EBV-positive undifferentiated carcinoma.
  • He was treated with resection of tongue base tumor and bilateral-neck dissection, and the defect at the tongue base was reconstructed with a free rectus abdominis myocutaneous flap.
  • Re-irradiation was added post-operatively because of a positive surgical margin at the tongue base.
  • Although it is unclear whether our case is recurrent or newly developed EBV-latently infected undifferentiated carcinoma, we propose that EBV-associated tumors should be carefully observed after treatment at least for more than 10 years.
  • [MeSH-major] Carcinoma / virology. Herpesviridae Infections / complications. Herpesvirus 4, Human / isolation & purification. Tongue Neoplasms / virology. Tumor Virus Infections / complications

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  • (PMID = 16934421.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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25. Pujary K, Rangarajan S, Nayak DR, Balakrishnan R, Ramakrishnan V: Hyalinizing clear cell carcinoma of the base of tongue. Int J Oral Maxillofac Surg; 2008 Jan;37(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing clear cell carcinoma of the base of tongue.
  • Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands.
  • There are only a few isolated cases reported in the literature involving the base of tongue.
  • A 57-year-old male patient presented with a lesion in the base of tongue, which was well enhanced on contrast computerized tomography scan.
  • Once confirmed by biopsy, the hyalinizing clear cell carcinoma was resected via a transcervical approach.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Salivary Gland Neoplasms / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17822882.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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26. Pederson AW, Haraf DJ, Witt ME, Stenson KM, Vokes EE, Blair EA, Salama JK: Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head Neck; 2010 Nov;32(11):1519-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.
  • BACKGROUND: Our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy.
  • METHODS: Between 1990 and 2004, 127 patients with stage III or IV base of tongue cancer were treated with chemoradiotherapy on protocol.
  • CONCLUSION: Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Tongue Neoplasms / mortality. Tongue Neoplasms / therapy

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  • (PMID = 20187015.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Interferon-alpha; 0 / Recombinant Proteins; 2S9ZZM9Q9V / Bevacizumab; 7673326042 / irinotecan; 99210-65-8 / interferon alfa-2b; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; X6Q56QN5QC / Hydroxyurea; XT3Z54Z28A / Camptothecin
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27. Yoshimoto S, Kawabata K, Mitani H, Yonekawa H, Beppu T, Fukushima H, Sasaki T: Treatment results for 84 patients with base of tongue cancer. Acta Otolaryngol Suppl; 2007 Dec;(559):123-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment results for 84 patients with base of tongue cancer.
  • OBJECTIVES: Because tumors originating from the base of the tongue are rare, few large-scale studies of such tumors have been performed.
  • PATIENTS AND METHODS: From 1971 to 2000, 84 patients with previously untreated and resectable squamous cell carcinoma of the base of the tongue were treated at the Head and Neck Department of the Cancer Institute Hospital, Tokyo.
  • [MeSH-major] Carcinoma, Squamous Cell. Tongue Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Hypopharyngeal Neoplasms / secondary. Laryngectomy. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Preoperative Care

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  • (PMID = 18340583.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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28. Jegannathen A, Swindell R, Yap B, Lee L, Sykes A, Mais K, Sanghera P, Hartley A, Glaholm J, Slevin N: Can synchronous chemotherapy be added to accelerated hypofractionated radiotherapy in patients with base of tongue cancer? Clin Oncol (R Coll Radiol); 2010 Apr;22(3):185-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can synchronous chemotherapy be added to accelerated hypofractionated radiotherapy in patients with base of tongue cancer?
  • AIM: To evaluate the tolerability of synchronous chemotherapy and accelerated hypofractionated radiotherapy in patients with locally advanced squamous cell carcinoma of the base of the tongue.
  • MATERIALS AND METHODS: Between 1999 and 2004, 43 patients with stage II-IV squamous cell carcinoma of the base of the tongue were treated with a combined modality of radiotherapy (prescribed 55 Gy in 20 fractions), synchronous chemotherapy and in some cases surgical neck dissection.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Squamous Cell / therapy. Radiotherapy / methods. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging

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  • [Copyright] Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20116980.001).
  • [ISSN] 1433-2981
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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29. Kumai Y, Ogata N, Yumoto E: Epithelial-myoepithelial carcinoma in the base of the tongue: a case report. Am J Otolaryngol; 2006 Jan-Feb;27(1):58-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial-myoepithelial carcinoma in the base of the tongue: a case report.
  • OBJECTIVES: To report a rare case of epithelial-myoepithelial carcinoma (EMC) of a minor salivary gland originating in the base of the tongue, which is a highly unusual location.
  • Endoscopic examination revealed a tumorous lesion 40 x 20 mm in the base of the tongue on the left side.
  • A biopsy was performed, and the lesion was histologically identified as squamous cell carcinoma.
  • The final diagnosis based on the histological and immunohistochemical findings was EMC.
  • CONCLUSION: We believe this report is the first description of EMC originating in the base of the tongue.
  • [MeSH-major] Carcinoma / pathology. Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Neoplasm Staging. Oral Surgical Procedures / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 16360826.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Cano ER, Lai SY, Caylakli F, Johnson JT, Ferris RL, Carrau RL, Snyderman CH, Gooding WE, Simenthal AA Jr, Myers EN: Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy. Head Neck; 2009 Nov;31(11):1431-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy.
  • BACKGROUND: Treatment of base of tongue (BOT) squamous cell carcinoma (SCC) has traditionally been associated with poor prognosis and significant morbidity.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Brachytherapy. Carcinoma, Squamous Cell / therapy. Radiation-Sensitizing Agents / administration & dosage. Tongue Neoplasms / therapy

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
  • (PMID = 19405086.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiation-Sensitizing Agents; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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31. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • It was diagnosed as LCNEC of the tongue base.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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32. Lawson JD, Otto K, Chen A, Shin DM, Davis L, Johnstone PA: Concurrent platinum-based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base. Head Neck; 2008 Mar;30(3):327-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent platinum-based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base.
  • BACKGROUND: Randomized data support use of chemotherapy concurrently with radiation in treatment of advanced squamous cell carcinoma (SCC) of the oropharynx.
  • Intensity modulated radiation therapy (IMRT) is increasingly being used to deliver such radiotherapy; no published reports specifically describe results of chemotherapy with IMRT for SCC of the base of tongue (BOT).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Tongue Neoplasms / mortality. Tongue Neoplasms / therapy

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc. Head Neck 2008
  • (PMID = 17657789.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NIMHD NIH HHS / MD / 5P60 MD000525; United States / NCI NIH HHS / CA / R01 CA112643; United States / NCI NIH HHS / CA / U01 CA101244
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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33. Kumar M, Bahl A, Sharma DN, Sharma R, Gupta R, Ahmed S, Julka PK, Rath GK: Cylindric cell carcinoma of the base of the tongue: a rare variant of squamous cell carcinoma. J Cancer Res Ther; 2009 Apr-Jun;5(2):124-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cylindric cell carcinoma of the base of the tongue: a rare variant of squamous cell carcinoma.
  • They have been known by myriads of nomenclature like cylindric carcinomas, nonkeratinizing sinonasal carcinoma, papillary carcinoma, cylindrical or columnar cell carcinoma, intermediate cell carcinoma, Schneiderian carcinoma, and Ringertz carcinoma.
  • They are considered a variant of nonkeratinizing squamous cell carcinoma.
  • Only passing references have been made for its presentation in oropharynx including tonsils and the base of the tongue.
  • We report here a rare case of transitional cell carcinoma presenting in the base of the tongue.
  • There are no separate treatment recommendations in the literature, and the management is on the lines of treatment of squamous cell carcinoma.
  • We report here a case of cylindric cell carcinoma presenting in the base of the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 19542670.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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34. Hitchcock YJ, Bentz BG, Sharma PK, Fang C, Tward JD, Pappas L, Chen J, Hayes JK, Shrieve DC: Planned neck dissection after definitive radiotherapy or chemoradiation for base of tongue cancers. Otolaryngol Head Neck Surg; 2007 Sep;137(3):422-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Planned neck dissection after definitive radiotherapy or chemoradiation for base of tongue cancers.
  • OBJECTIVES: The study goal was to analyze the role of planned neck dissection for squamous cell carcinoma of the base of the tongue treated with definitive radiotherapy or chemoradiation.
  • STUDY DESIGN, SETTING: We conducted a retrospective study of patients with squamous cell carcinoma of the base of the tongue undergoing planned neck dissection after definitive radiotherapy or chemoradiation.
  • SIGNIFICANCE: Planned neck dissection following definitive radiotherapy or chemoradiation is highly effective in achieving regional control of squamous cell carcinoma of the base of the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Neck Dissection. Tongue Neoplasms / therapy

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  • (PMID = 17765769.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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35. Dequanter D, Andry G, Lothaire P, Larsimont D, Deraemaecker R: Wide localized excision and reconstruction for minor salivary gland tumours. B-ENT; 2005;1(4):187-90
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Four consecutive patients suffering from minor salivary gland tumours of the upper aerodigestive tract were treated: two had adenoid cystic carcinomas (one of the lateral oropharyngeal mucosa, one of the retromolar area); one had a polymorphous low-grade carcinoma (at the base of the tongue); and one had mucoepidermoid carcinoma (on the floor of the mouth).
  • One patient is alive with a recurrent tumour of the pterygomaxillary fossa (without trismus) sixteen years after the original operation; another patient is free of recurrent disease at the base of the tongue but has recently undergone surgery, with success, for two pulmonary metastases sixty months after the initial surgery.
  • CONCLUSIONS: For minor salivary gland carcinoma of the head and neck, large resection with immediate reconstruction affords fast recovery and long-lasting locoregional control.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neck Dissection / methods. Reconstructive Surgical Procedures / methods. Salivary Gland Neoplasms / surgery

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  • (PMID = 16429751.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
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36. Subramanian B, Agrawal K, Panda K: Basaloid squamous carcinoma of mandible. J Craniofac Surg; 2009 Jan;20(1):151-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous carcinoma of mandible.
  • Basaloid squamous carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region.
  • Basaloid squamous carcinoma is more aggressive and has a poorer prognosis, although histologically, it is associated with squamous cell carcinoma and squamous atypia.
  • The usual site of occurrence for basaloid squamous carcinoma is the base of the tongue, hypopharynx (pyriform sinus), and the supraglottic larynx (Wain et al.
  • We are reporting an unusual case of basaloid squmous carcinoma of the mandible with no secondaries and features of sarcomatoid pattern histologically.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Biopsy, Fine-Needle. Bone Wires. Female. Follow-Up Studies. Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Humans. Neck Dissection. Radiography, Panoramic. Radiotherapy, Adjuvant

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  • (PMID = 19165013.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Tixier H, Fraisse J, Bruchon Y, Cuisenier J: [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath]. J Chir (Paris); 2009 Oct;146(5):503-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath].
  • [Transliterated title] Métastase d'une tumeur de la base de langue sur un système d'accès veineux central totalement implantable.
  • We report a case of metastatic implantation at a port site from a primary cancer of the base of the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell. Catheterization, Central Venous / adverse effects. Infusion Pumps, Implantable / adverse effects. Oropharyngeal Neoplasms. Tongue Neoplasms
  • [MeSH-minor] Aged. Biopsy. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Positron-Emission Tomography. Skin Neoplasms / secondary. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19833338.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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38. Marioni G, Savastano M, Mattiello L, Koussis H, Carpenè S, Marino F, Staffieri A: Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. Am J Otolaryngol; 2007 Jul-Aug;28(4):284-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
  • The endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas.
  • Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis.
  • Although the most common presenting sign of ESCC is definitely a peri- or postmenopausal vaginal bleeding, we report for the first time the occurrence of tongue base bleeding as first manifestation of disseminated neuroendocrine ESCC.
  • From a clinical viewpoint, tongue metastasis from primary endometrial carcinoma is a manifestation of widespread disease.
  • Albeit, our patient underwent complete hysterectomy and postoperative chemotherapy, she died of disseminated disease 3 months after ESCC diagnosis.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Endometrial Neoplasms / pathology. Tongue Neoplasms / secondary

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  • (PMID = 17606050.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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39. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Pardo Romero G, Trinidad Ramos G, Blasco Huelva A: [Adenoid cystic carcinoma of tongue. Report of a case and literature review]. An Otorrinolaringol Ibero Am; 2006;33(5):449-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of tongue. Report of a case and literature review].
  • [Transliterated title] Carcinoma adenoide quístico de lengua. A propósito de un caso y revisión de la literatura.
  • We report the clinical case of an adenoid cystic carcinoma on the base of the tongue, a rare malignant tumor of slow-growing but aggressive with a propepnsity for perineural invasion.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Humans. Laryngectomy. Magnetic Resonance Imaging. Male. Middle Aged. Tongue / pathology. Tongue / surgery. Treatment Outcome

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  • (PMID = 17091857.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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40. Leong SC, Pinder E, Sasae R, Mortimore S: Mucoepidermoid carcinoma of the tongue. Singapore Med J; 2007 Oct;48(10):e272-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of the tongue.
  • We report a 27-year-old Congolese man with mucoepidermoid carcinoma (MEC) of the tongue base, which presented as spontaneous intraoral bleeding.
  • Optimal treatment of tongue base MEC is unknown.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17909664.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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41. Sundaram K, Schwartz J, Har-El G, Lucente F: Carcinoma of the oropharynx: factors affecting outcome. Laryngoscope; 2005 Sep;115(9):1536-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the oropharynx: factors affecting outcome.
  • OBJECTIVES/HYPOTHESIS: To assess the value of both patient- and tumor-related factors of oropharyngeal squamous cell carcinoma in predicting patient outcome, with respect to the three primary subsites of the disease.
  • METHODS: A chart review was conducted of 126 patients diagnosed with squamous cell carcinoma of the oropharynx over a 10-year period.
  • 1) base of tongue, 2) tonsil and pillars, and 3) uvula, soft palate, and posterior pharyngeal wall.
  • Base-of-tongue lesions responded significantly worse to treatment than did tonsil and pillar or uvula, soft palate, and posterior pharyngeal wall lesions (P = .014).
  • The disease-free survival for base-of-tongue cancer was significantly worse than for tonsil and pillar or for uvula, soft palate, and posterior pharyngeal wall cancer (P = .010).
  • Among the oropharyngeal subsites, squamous cell carcinoma of the base of tongue was associated with the worst outcome.
  • [MeSH-major] Carcinoma, Squamous Cell / physiopathology. Oropharyngeal Neoplasms / physiopathology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palate, Soft. Sex Factors. Tongue. Tonsillar Neoplasms. Treatment Outcome. Uvula

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  • (PMID = 16148691.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Suzuki H, Katoh A, Udaka T, Shiomori T, Fujimura T, Fujimura K, Kitamura T: Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol; 2006 Jun;126(6):653-6
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing clear cell carcinoma arising from the base of the tongue.
  • Hyalinizing clear cell carcinoma is a low-grade indolent and rare salivary gland tumor originally described by Milchgrub et al. in 1994.
  • We herein report a case of this tumor of the base of the tongue.
  • Computed tomography and magnetic resonance imaging revealed a 40x30-mm well-defined ovoid tumor arising from the base of the tongue.
  • Because the tumor invasion of the surrounding tissue was limited, the surgical defect at the base of the tongue was relatively small, and no reconstructive procedure needed to be performed.
  • The tumor was histopathologically diagnosed as hyalinizing clear cell carcinoma of the minor salivary gland.
  • The pathology, clinical characteristics, and treatment of hyalinizing clear cell carcinoma are bibliographically reviewed.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Hyalin. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laryngoscopy. Magnetic Resonance Imaging. Neck Dissection. Stromal Cells / pathology. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 16720452.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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43. Tezal M, Sullivan Nasca M, Stoler DL, Melendy T, Hyland A, Smaldino PJ, Rigual NR, Loree TR: Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. Arch Otolaryngol Head Neck Surg; 2009 Apr;135(4):391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic periodontitis-human papillomavirus synergy in base of tongue cancers.
  • OBJECTIVE: To assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in patients with base of tongue cancers.
  • PATIENTS: Thirty patients newly diagnosed with base of tongue squamous cell carcinoma between 1999 and 2005 for whom both tumor samples and periodontal records were available.
  • After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold (odds ratio, 3.96; 95% confidence interval, 1.18-13.36) increased risk of HPV-positive tumor status.
  • CONCLUSIONS: Chronic periodontitis may be a significant factor in the natural history of HPV infection in patients with base of tongue cancers.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Chronic Periodontitis / epidemiology. Human papillomavirus 16 / isolation & purification. Human papillomavirus 18 / isolation & purification. Tongue Neoplasms / virology

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  • (PMID = 19380363.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R03CA119262; United States / NIDCR NIH HHS / DE / T32-DE07034
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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44. Chien CY, Su CY, Hwang CF, Chuang HC, Jeng SF, Chen YC: Ablation of advanced tongue or base of tongue cancer and reconstruction with free flap: functional outcomes. Eur J Surg Oncol; 2006 Apr;32(3):353-7
Genetic Alliance. consumer health - Tongue cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ablation of advanced tongue or base of tongue cancer and reconstruction with free flap: functional outcomes.
  • AIM: To evaluate the functional outcomes of patients who underwent total or nearly total glossectomy for advanced tongue or base of tongue cancer.
  • The cumulative 4-year survival rates were 63.8% for tongue cancer and 42.9% for base of tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Catheter Ablation. Glossectomy / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 16455224.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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45. Attner P, Du J, Näsman A, Hammarstedt L, Ramqvist T, Lindholm J, Marklund L, Dalianis T, Munck-Wikland E: The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer; 2010 Jun 15;126(12):2879-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of human papillomavirus in the increased incidence of base of tongue cancer.
  • Following our previous research on tonsillar cancer, we assessed the increase in the incidence of base of tongue cancer and the prevalence of HPV in this disease.
  • Between 1998 and 2007, 109 patients were diagnosed for base of tongue cancer in Stockholm county.
  • An overall increase in the incidence of base of tongue cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden.
  • The prevalence of HPV in base of tongue cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05).
  • The incidence of base of tongue cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / virology. Tongue Neoplasms / virology

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  • (PMID = 19856308.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Papillomavirus E7 Proteins; 0 / Repressor Proteins; 0 / oncogene protein E7, Human papillomavirus type 16
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46. Rieger JM, Zalmanowitz JG, Li SY, Sytsanko A, Harris J, Williams D, Seikaly H: Functional outcomes after surgical reconstruction of the base of tongue using the radial forearm free flap in patients with oropharyngeal carcinoma. Head Neck; 2007 Nov;29(11):1024-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcomes after surgical reconstruction of the base of tongue using the radial forearm free flap in patients with oropharyngeal carcinoma.
  • BACKGROUND: Historically, the prevention of functional morbidity after multimodal treatment for squamous cell carcinoma in patients with large base of tongue lesions has been challenging.
  • The purpose of the present research is to report prospectively collected speech and swallowing outcomes for patients with disease that encompassed half or more of the base of tongue.
  • In the early postoperative period, patients with 100% of their base of tongue resected experienced decreased intelligibility, which improved by the half-way mark of the evaluations.
  • CONCLUSIONS: The results of this study suggest that surgical reconstruction of the base of tongue using the radial forearm free flap in patients with large base of tongue lesions can lead to functional speech and swallowing results.
  • [MeSH-major] Carcinoma / surgery. Glossectomy. Oropharyngeal Neoplasms / surgery. Surgical Flaps

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  • (PMID = 17405174.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Laccourreye O, Seccia V, Ménard M, Garcia D, Vacher C, Holsinger FC: Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base. Ann Otol Rhinol Laryngol; 2009 Jun;118(6):428-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base.
  • OBJECTIVES: In a retrospective review of an inception cohort of 26 patients with an isolated, previously untreated, moderately to well-differentiated invasive squamous cell carcinoma of the lateral tongue base, consecutively managed with an extended lateral pharyngotomy approach at a single tertiary referral care center, the authors review the key surgical points, highlight the potential technical pitfalls, and document the complications and long-term functional and oncological outcomes in terms of survival and local control.
  • CONCLUSIONS: Such results suggest that extended lateral pharyngotomy should be integrated among the various conservative treatment options available to patients with selected carcinomas of the lateral tongue base.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neck Dissection / methods. Pharynx / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19663374.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Li XH, Sun JL, Zhang P, Hu J, Zhang CP, Ji T: [Nanomanipulation of sections of human tongue squamous cell carcinoma by atomic force microscopy]. Zhonghua Yi Xue Za Zhi; 2006 Feb 28;86(8):520-5
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  • [Title] [Nanomanipulation of sections of human tongue squamous cell carcinoma by atomic force microscopy].
  • OBJECTIVE: To investigate the appropriate nanomanipulation of slides of human tongue squamous cell carcinoma tissue and cultured cells by atomic force microscopy (AFM), and develop methods to improve the resolution and contrast of AFM images.
  • METHODS: Human tongue squamous carcinoma cells of the line Tca8113 were cultured.
  • Samples of human tongue squamous carcinoma were collected from 15 cases.
  • CONCLUSION: A series of modified techniques of preparing and treating AFM samples, such as adhering the sections onto mica slide, dissolving of epoxy resin by hydrogen dioxide and removal of paraffin by dimethylbenzene, were developed, thus realizing high resolving power AFM imaging, especially for nuclear membrane, and nucleolus, and providing a base of AFM location, dissection, isolation and obtainment at nanometer scale.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Microscopy, Atomic Force / methods. Nanotechnology / methods. Tongue Neoplasms / pathology

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  • (PMID = 16681879.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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49. Esposito E, Cassiano B, Cinquegrani F: Salivary glands: report of a rare case of myoepithelial carcinoma involving tongue base treated by CO2 Laser. Acta Otorhinolaryngol Ital; 2009 Jun;29(3):156-9
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  • [Title] Salivary glands: report of a rare case of myoepithelial carcinoma involving tongue base treated by CO2 Laser.
  • Epithelial-myoepithelial carcinoma is a rare malignant tumour of the salivary glands.
  • Herewith, the clinical evolution, anatomo-pathological characteristics and treatment adopted are described in a case occurring in the minor salivary glands of the tongue base.
  • In fact, due to the rarity of the epithelial-myoepithelial carcinoma, there is no uniformity of data in the literature and very different therapeutic strategies have been suggested.
  • Results obtained in the case described confirm that conservative surgery is feasible in this type of neoplastic lesion of the tongue.
  • [MeSH-major] Carcinoma / surgery. Lasers, Gas / therapeutic use. Sublingual Gland Neoplasms / surgery. Tongue Neoplasms / surgery

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  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1993;422(5):389-96 [8322454.001]
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  • (PMID = 20140162.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2815361
  • [Keywords] NOTNLM ; CO2 Laser / Myoepithelial carcinoma
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50. Liu B, Pan Z, Ji W, Wang J: [Study of reserving unilateral arytenoid cartilage to improve voice quality in supracricoid partial laryngectomy with anastomosis of cricoid cartilage, base of tongue and epiglottis]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Nov;19(21):961-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study of reserving unilateral arytenoid cartilage to improve voice quality in supracricoid partial laryngectomy with anastomosis of cricoid cartilage, base of tongue and epiglottis].
  • OBJECTIVE: To study the surgical technique of reserving unilateral arytenoid cartilage and the effects on improving voice quality in supracricoid partial laryngectomy with anastomosis of cricoid cartilage,base of tongue and epiglottis.
  • Anastomosis of cricoid cartilage,base of tonge and epiglottis was used to reconstruct laryngeal function.
  • [MeSH-major] Arytenoid Cartilage / surgery. Carcinoma, Squamous Cell / surgery. Laryngeal Neoplasms / surgery. Laryngectomy / methods

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  • (PMID = 16494035.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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51. Seikaly H, Rieger J, O'Connell D, Ansari K, Alqahtani K, Harris J: Beavertail modification of the radial forearm free flap in base of tongue reconstruction: technique and functional outcomes. Head Neck; 2009 Feb;31(2):213-9
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  • [Title] Beavertail modification of the radial forearm free flap in base of tongue reconstruction: technique and functional outcomes.
  • This task is especially difficult in cancer of the base of tongue.
  • The purpose of this manuscript is to describe the beavertail modification of the radial forearm-free flap in base of tongue reconstruction.
  • METHODS: Thirty-one consecutive patients treated for base of tongue cancer with primary surgery were followed prospectively.
  • CONCLUSIONS: The beavertail modification of the radial forearm arm flap seems to provide the reconstructive elements that allow patients with large base of tongue extirpations to develop functional swallowing and speech production postoperatively.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 19073000.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Vidiri A, Ruscito P, Pichi B, Pellini R, Covello R, Sperduti I, Di Giovanni S, Spriano G, Crecco M: Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor. J Exp Clin Cancer Res; 2007 Dec;26(4):575-82
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  • [Title] Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor.
  • The diagnosis of oral cavity and oropharyngeal tumors can be obtained through clinical examination and biopsy.
  • The aim of this study was to define the accuracy of clinical and MRI T staging of oral cavity and base of the tongue tumors and correlate the results with pathological data.
  • Fifty-nine patients affected by squamous cell carcinoma and 1 case of adenoido-cystic carcinoma were examined by means of a superconductive MR unit, using SE T1, and fat-suppressed T2 weighted sequences before contrast medium infusion.
  • [MeSH-major] Magnetic Resonance Imaging. Mouth Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Male. Mouth / pathology. Neoplasm Staging

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  • (PMID = 18365555.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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53. Kásler M, Fodor J, Oberna F, Major T, Polgár C, Takácsi-Nagy Z: Salvage surgery for locoregional failure after definitive radiotherapy for base of tongue cancer. In Vivo; 2008 Nov-Dec;22(6):803-6
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  • [Title] Salvage surgery for locoregional failure after definitive radiotherapy for base of tongue cancer.
  • In this study, the results of definitive radiotherapy (RT) and salvage surgery treatment of base of tongue cancer were evaluated.
  • [MeSH-major] Carcinoma / surgery. Salvage Therapy / methods. Tongue Neoplasms / surgery
  • [MeSH-minor] Biopsy. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Postoperative Complications / classification. Survival Analysis. Survivors. Treatment Failure

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  • (PMID = 19181010.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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54. Hancock SB, Krempl GA, Canfield V, Bogardus C, Kojouri K, Kaneaster SK, Medina JE: Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. Laryngoscope; 2008 Aug;118(8):1357-61
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  • [Title] Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy.
  • OBJECTIVES/HYPOTHESIS: To assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage III and IV base of tongue cancer.
  • STUDY DESIGN: Subgroup analysis of patients with base of tongue cancer enrolled in a single-institution prospective phase II trial, evaluating an organ-preservation approach in the treatment of locally advanced head and neck cancer.
  • CONCLUSIONS: The treatment regimen studied is remarkably effective in stage III and IV base of tongue cancer with 100% of patients completing the protocol alive to date.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Disease-Free Survival. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Nervous System Diseases / chemically induced. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 18528311.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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55. Ye H, Yu T, Temam S, Ziober BL, Wang J, Schwartz JL, Mao L, Wong DT, Zhou X: Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics; 2008;9:69
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  • [Title] Transcriptomic dissection of tongue squamous cell carcinoma.
  • BACKGROUND: The head and neck/oral squamous cell carcinoma (HNOSCC) is a diverse group of cancers, which develop from many different anatomic sites and are associated with different risk factors and genetic characteristics.
  • The oral tongue squamous cell carcinoma (OTSCC) is one of the most common types of HNOSCC.
  • CONCLUSION: In summary, our study provided a transcriptomic signature for OTSCC that may lead to a diagnosis or screen tool and provide the foundation for further functional validation of these specific candidate genes for OTSCC.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Expression Profiling. Tongue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. Biomarkers / metabolism. Case-Control Studies. Collagen / metabolism. DNA Primers / genetics. Female. Humans. Immunohistochemistry. Interleukin-8 / genetics. Interleukin-8 / metabolism. Male. Matrix Metalloproteinase 9 / genetics. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Oligonucleotide Array Sequence Analysis. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18254958.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / K22 DE014847; United States / NCI NIH HHS / CA / P01 CA106451; United States / NIDCR NIH HHS / DE / R01 DE015970; United States / NCI NIH HHS / CA / R03 CA114688; United States / NIDCR NIH HHS / DE / R03 DE016569
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / DNA Primers; 0 / IL8 protein, human; 0 / Interleukin-8; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 9007-34-5 / Collagen; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC2262071
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56. Yang AK, Liu TR, Chen FJ, Ma XF, Guo ZM, Song M, Li QL, Zeng ZY: [Survival analysis of 229 patients with advanced squamous cell carcinoma of the oral tongue]. Ai Zheng; 2008 Dec;27(12):1315-20
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  • [Title] [Survival analysis of 229 patients with advanced squamous cell carcinoma of the oral tongue].
  • BACKGROUND & OBJECTIVE: Patients with advanced squamous cell carcinoma (SCC) of the oral tongue have poor prognosis.
  • This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) SCC of the oral tongue.
  • METHODS: Complete clinical and follow-up data of 229 patients with pathologically confirmed advanced SCC of the oral tongue, initially treated at Sun Yat-sen University Cancer Center were retrospectively analyzed.
  • Univariate analysis showed that age, tongue base invasion, cervical lymphatic metastasis, stage, surgical treatment, recurrence and residual tumor were risk factors affecting prognosis (P<0.05).
  • CONCLUSIONS: The prognosis of patients with advanced SCC of the oral tongue is poor.
  • [MeSH-major] Carcinoma, Squamous Cell. Glossectomy / methods. Neoplasm Recurrence, Local. Tongue Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging. Neoplasm, Residual. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Factors. Survival Analysis. Survival Rate. Young Adult


57. Shiboski CH, Schmidt BL, Jordan RC: Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer; 2005 May 1;103(9):1843-9
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  • [Title] Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years.
  • BACKGROUND: An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe.
  • Although the association between human papillomavirus infection and tonsillar carcinoma is now well established, to the authors' knowledge little is known about incidence trends in tonsillar carcinoma among younger adults.
  • The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.
  • METHODS: Using the 1973-2001 Surveillance, Epidemiology and End Results (SEER) database, we computed age, race, and site-specific trends of oral and pharyngeal (excluding nasopharynx) carcinoma incidence rates.
  • There was a statistically significant increase in the incidence of oral tongue SCC (APC = +2.1; P < 0.001), base of tongue SCC (APC = +1.7; P = 0.04), and palatine tonsil SCC (APC = +3.9; P < 0.001) among younger white individuals, whereas the incidence of SCC in all other oral and pharyngeal sites decreased or remained constant.
  • CONCLUSIONS: The increase in tonsil SCC incidence from 1973 to 2001 paralleled the increase in tongue SCC, whereas SCC in all other oral and pharyngeal sites remained constant or decreased.
  • This may suggest similar etiologic factors for SCC affecting the palatine tonsils and tongue in younger populations.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Tongue Neoplasms / epidemiology. Tonsillar Neoplasms / epidemiology

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 15772957.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA095231; United States / NIDCR NIH HHS / DE / DE14609; United States / NIDCR NIH HHS / DE / K23 DE00443; United States / NIDCR NIH HHS / DE / P01DE13904
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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58. Windfuhr JP, Remmert S: Infrahyoid myofascial flap for tongue reconstruction. Eur Arch Otorhinolaryngol; 2006 Nov;263(11):1013-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infrahyoid myofascial flap for tongue reconstruction.
  • For selected cases, reconstruction of the tongue may be required after tumor removal.
  • This study was undertaken to demonstrate a simplified concept of tongue reconstruction with emphasis on infrahyoid myofascial flaps (IMF).
  • The defects of the tongue were classified in 23 patients according to the extent of tumor growth, functional and surgical aspects.
  • The oral tongue (OT; n = 1), base of tongue (BT; n = 12) or both areas (OT and BT; n = 10) were involved, with (n = 14) or without (n = 9) infiltration of adjacent tissues.
  • IMF serves as a reliable tool for minor or major reconstructive procedures of the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Otorhinolaryngologic Surgical Procedures / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 16868774.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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59. Ekberg T, Nestor M, Engström M, Nordgren H, Wester K, Carlsson J, Anniko M: Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue. Int J Oncol; 2005 May;26(5):1177-85
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  • [Title] Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue.
  • HER2, HER3, and HER4 were evaluated by immunohistochemistry in 19 cases of metastatic squamous cell carcinoma of the oral cavity and base of tongue.
  • In order to further investigate the distribution of HER3, two HER3 expressing cell lines originating from tongue cancer were analysed in vitro, using radiolabelled anti-HER3 antibodies directed to the extracellular domains of the receptor.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Expression Profiling. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis. Receptor, ErbB-3 / biosynthesis. Tongue Neoplasms / genetics

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  • (PMID = 15809707.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ligands; EC 2.7.10.1 / ERBB4 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-3; EC 2.7.10.1 / Receptor, ErbB-4
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60. Diaz R, Blakey MD, Murphy PB, Cryar AK, Cmelak AJ: Thyroid storm after intensity-modulated radiation therapy: a case report and discussion. Oncologist; 2009 Mar;14(3):233-9
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  • A 43-year-old man with locally advanced squamous cell carcinoma of the base of tongue was treated with induction chemotherapy followed by intensity-modulated radiation therapy (IMRT).
  • Diagnosis of the patient's hyperthyroidism and probable thyroid storm was difficult to recognize because of the significant overlap between the signs and symptoms of severe thyrotoxicosis and the expected toxicities of his cancer therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Radiation Injuries / etiology. Thyroid Crisis / etiology. Tongue Neoplasms / radiotherapy

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  • (PMID = 19286762.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thyroid Hormones
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61. Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, Hartig GK: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope; 2008 Aug;118(8):1377-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy.
  • METHODS: Seventy-nine patients from 1991 to 2005 with primary T1 to T4 oropharyngeal squamous cell carcinoma (base of tongue, n = 31; soft palate, n = 1; tonsils, n = 47) were treated with primary radiotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Female. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Observer Variation. Prognosis. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18418275.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X: MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett; 2010 Sep 24;584(18):4115-20
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  • [Title] MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
  • Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear.

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  • [Copyright] Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 20816961.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NCI NIH HHS / CA / R01 CA139596-03; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / CA139596-03; United States / NIDCR NIH HHS / DE / K22 DE014847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Dnd1 protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / MIRN24 microRNA, human; 0 / MicroRNAs; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ NIHMS234020; NLM/ PMC2964934
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63. Hartl DM, Dauchy S, Escande C, Bretagne E, Janot F, Kolb F: Quality of life after free-flap tongue reconstruction. J Laryngol Otol; 2009 May;123(5):550-4
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  • [Title] Quality of life after free-flap tongue reconstruction.
  • OBJECTIVE: To analyse correlations between quality of life measures, aspiration and extent of surgical resection in patients who have undergone free-flap tongue reconstruction.
  • PATIENTS AND METHODS: Nine consecutive patients (seven men and two women; average age 51 years) who had been diagnosed with T4a carcinoma of the mobile tongue and/or tongue base and treated by glossectomy, free-flap reconstruction, and either radiation therapy or chemoradiation responded to the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire, the performance status scale questionnaire and the hospital anxiety-depression scale questionnaire, an average of 43 months after treatment (range 18-83 months).
  • RESULTS: Scores for the swallowing and aspiration domains of the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire were significantly correlated with the extent of tongue base resection (Spearman's correlation, p = 0.037 and 0.042, respectively).
  • Despite a strong correlation between the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire results and the performance status scale global scores (correlation coefficient = 0.89, p = 0.048), the performance status scale domain scores were not correlated with the extent of tongue resection.
  • Clinically apparent aspiration was not correlated with the extent of tongue resection, nor were the anxiety or depression scores.
  • CONCLUSIONS: Our results imply that the volume of tongue base resection is a major factor in swallowing- and aspiration-related quality of life following tongue resection and free-flap reconstruction.
  • Free-flap reconstruction does not seem to palliate the effect of the loss of functional tongue base volume, as regards swallowing-related quality of life.
  • [MeSH-major] Carcinoma / surgery. Reconstructive Surgical Procedures / methods. Tongue / surgery. Tongue Neoplasms / surgery

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  • (PMID = 18796181.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Mackle T, O'Dwyer T: A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review. J Laryngol Otol; 2006 May;120(5):393-6
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  • [Title] A comparative analysis of anterior versus posterior squamous cell carcinoma of the tongue: a 10-year review.
  • INTRODUCTION: The study sought to compare and contrast squamous cell carcinoma (SCC) of the anterior mobile tongue with SCC of the tongue base, with emphasis on clinical presentation, management and outcome.
  • METHODS: This was a retrospective, comparative analysis of patients treated for SCC of the tongue over a 10-year period.
  • RESULTS: The study included 142 patients, of whom 86 were treated for SCC of the anterior tongue and 56 for tongue base lesions.
  • Patients with carcinoma of the anterior tongue tended to present with a visible lump or ulceration of the tongue, whereas the majority of patients with tongue base SCC presented with pain.
  • Sixty per cent of anterior tongue lesions were early stage (I or II) at initial presentation as compared with 21 per cent of tongue base lesions.
  • CONCLUSION: Patients with anterior tongue lesions had a better prognosis, but this was not statistically significant when adjusted for stage.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Regression Analysis. Retrospective Studies. Sex Distribution. Survival Rate

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  • (PMID = 16563198.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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65. Ahmed M, Schmidt M, Sohaib A, Kong C, Burke K, Richardson C, Usher M, Brennan S, Riddell A, Davies M, Newbold K, Harrington KJ, Nutting CM: The value of magnetic resonance imaging in target volume delineation of base of tongue tumours--a study using flexible surface coils. Radiother Oncol; 2010 Feb;94(2):161-7
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  • [Title] The value of magnetic resonance imaging in target volume delineation of base of tongue tumours--a study using flexible surface coils.
  • We studied the feasibility of using flexible surface (flex-L) coils to obtain MR images for MR-CT fusion to assess the benefit of MRI over CT alone in planning base of tongue tumours.
  • CONCLUSION: MRI improves the definition of tongue base tumours and neurological structures.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Magnetic Resonance Imaging / instrumentation. Radiotherapy Planning, Computer-Assisted / instrumentation. Tongue Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20096947.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 0 / gadoterate meglumine; 6HG8UB2MUY / Meglumine; K2I13DR72L / Gadolinium DTPA
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66. O'Connell DA, Rieger J, Harris JR, Dziegielewski P, Zalmanowitz J, Sytsanko A, Li S, Wolfaardt J, Hart RD, Seikaly H: Swallowing function in patients with base of tongue cancers treated with primary surgery and reconstructed with a modified radial forearm free flap. Arch Otolaryngol Head Neck Surg; 2008 Aug;134(8):857-64
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  • [Title] Swallowing function in patients with base of tongue cancers treated with primary surgery and reconstructed with a modified radial forearm free flap.
  • OBJECTIVE: To report swallowing outcomes and biomechanical properties of the base of the tongue (BOT) and the posterior pharyngeal wall (PPW) in patients who undergo surgical reconstruction with the beavertail modification of radial forearm free flap after primary resection of BOT cancer.
  • PATIENTS: Patients diagnosed as having primary carcinoma of the BOT were treated with primary surgical resection and reconstruction followed by radiotherapy.
  • [MeSH-major] Deglutition Disorders / physiopathology. Glossectomy. Postoperative Complications / physiopathology. Surgical Flaps. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biomechanical Phenomena. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pharynx / physiopathology. Prospective Studies. Radiotherapy, Adjuvant. Respiratory Aspiration / physiopathology. Tongue / physiopathology

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  • (PMID = 18711061.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Falvo L, Berni A, Catania A, D'Andrea V, Palermo S, Giustiniani C, De Antoni E: Sclerosing papillary carcinoma arising in a lingual thyroid: report of a case. Surg Today; 2005;35(4):304-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing papillary carcinoma arising in a lingual thyroid: report of a case.
  • Tumors with identical pathological characteristics to those arising in thyroid tissue may be present in ectopic locations, but there are very few cases of malignant ectopic thyroid tumors reported in the literature.
  • We present a review of this phenomenon and report a case of papillary carcinoma of the base of the tongue, located in ectopic lingual thyroid tissue, in a 30-year-old woman.
  • The patient's presenting symptoms were dysphagia and oral bleeding, and we performed radical resection of the neoformation at the base of the tongue with part of the muscles of the floor of the mouth and the body of the hyoid bone, as well as total thyroidectomy.
  • Histological examination revealed a "sclerosing" papillary carcinoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Papillary / therapy. Choristoma / pathology. Thyroid Gland. Tongue Neoplasms / pathology. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Sclerosis / therapy

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  • (PMID = 15815847.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Sugi M, Yanishi M, Shimada O, Kawakita S, Murota T, Shikata N: [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report]. Hinyokika Kiyo; 2008 May;54(5):373-6
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  • [Title] [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report].
  • Prostatic neuroendocrine (NE) carcinoma is a rare disease and the NE differentiation in prostate cancer is characterized by poor prognosis, rapidly progressing tumor and an androgen-independent state, for which there is currently no successful therapy.
  • Herein, we report a case of NE differentiatiated prostatic cancer, which metastasized to the base of tongue, intraorbit and brain stem.
  • This is the first Japanese report of prostate cancer metastasis to the brain stem and base of the tongue.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Stem Neoplasms / secondary. Carcinoma, Neuroendocrine / pathology. Cell Differentiation. Orbital Neoplasms / secondary. Prostatic Neoplasms / pathology. Tongue Neoplasms / secondary
  • [MeSH-minor] Androgen Antagonists / therapeutic use. Drug Resistance, Neoplasm. Humans. Male. Middle Aged


69. Hartl DM, Kolb F, Bretagne E, Bidault F, Sigal R: Cine-MRI swallowing evaluation after tongue reconstruction. Eur J Radiol; 2010 Jan;73(1):108-13
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  • [Title] Cine-MRI swallowing evaluation after tongue reconstruction.
  • OBJECTIVE: To determine the feasibility of cine-MRI for non-invasive swallowing evaluation after surgery for lingual carcinoma with reconstruction using microvascular free flaps.
  • METHODS: Ten patients with stage IV carcinoma of the mobile tongue and/or tongue base treated by surgical resection and reconstruction with a free flap were evaluated after an average of 4.3 years (range: 1.5-11 years), using cine-MRI in "single-shot fast spin echo" (SSFSE) mode.
  • Tongue base-pharyngeal wall contact was observed in 5 cases.
  • An increased anterior tongue recoil, increased mandibular recoil, increased posterior oropharyngeal wall advancement and an increased laryngeal elevation were observed in 4 cases.
  • CONCLUSIONS: Cine-MRI is a safe, non-invasive technique for the evaluation of the mobility of oral and oropharyngeal structures after free-flap reconstruction of the tongue.
  • [MeSH-major] Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Magnetic Resonance Imaging, Cine / methods. Reconstructive Surgical Procedures / adverse effects. Tongue Neoplasms / surgery

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19091505.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
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70. Gupta R, Gupta K, Gupta R: Polymorphous low-grade adenocarcinoma of the tongue: a case report. J Med Case Rep; 2009;3:9313

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polymorphous low-grade adenocarcinoma of the tongue: a case report.
  • INTRODUCTION: Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions.
  • Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of 'terminal duct carcinoma'.
  • In rare cases, the mass can also occur in the tongue.
  • We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.
  • CASE PRESENTATION: A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa.
  • Its occurrence in the tongue is rare with very few cases reported in the literature.
  • It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.

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  • (PMID = 20062742.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803836
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71. Yagi S, Kamei Y, Nakayama B, Toriyama K, Torii S: A new design for free flap reconstruction of the tongue and oropharynx. J Reconstr Microsurg; 2008 Apr;24(3):211-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new design for free flap reconstruction of the tongue and oropharynx.
  • Radical resection of tongue and oropharyngeal carcinomas often results in complex defects that are challenging to reconstruct.
  • The first reconstructs the tongue, the second the tongue base, the third the oral floor, and the fourth the lateral wall.
  • Twenty-three patients (17 men and 6 women) with an average age of 60 years underwent immediate reconstruction using a free flap after radical resection of a malignant carcinoma of tongue or oropharynx using a free flap.
  • Moreover, the functional outcome in patients with and without a tongue base defect was compared.
  • Swallowing in patients with and without a tongue base defect was similar, but speech was more impaired in patients who had a tongue base defect.
  • [MeSH-major] Oropharynx / surgery. Surgical Flaps. Tongue / surgery
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / surgery. Deglutition. Female. Humans. Male. Microsurgery / methods. Middle Aged. Oropharyngeal Neoplasms / surgery. Patient Satisfaction. Speech Intelligibility. Tongue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18491260.001).
  • [ISSN] 0743-684X
  • [Journal-full-title] Journal of reconstructive microsurgery
  • [ISO-abbreviation] J Reconstr Microsurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X: Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer; 2010 Aug 1;127(3):505-12
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
  • Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC).

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  • (PMID = 20232393.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NIDCR NIH HHS / DE / DE014847-05S1; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / R03 CA135992-01A1; United States / NCI NIH HHS / CA / CA135992-01A1; United States / NIDCR NIH HHS / DE / K22 DE014847; United States / NIDCR NIH HHS / DE / K22 DE014847-05S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RHOC protein, human; 0 / RNA, Messenger; 0 / ROCK2 protein, human; EC 2.7.11.1 / rho-Associated Kinases; EC 3.6.5.2 / rho GTP-Binding Proteins
  • [Other-IDs] NLM/ NIHMS203801; NLM/ PMC2885137
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73. Soderberg C, Perez DS, Ukpo OC, Liang X, O'Reilly AG, Moore EJ, Kademani D, Smith DI: Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas. Cytogenet Genome Res; 2008;121(3-4):201-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas.
  • The first were oral tongue squamous cell carcinomas (SCCs) and the second were base of tongue/tonsillar (oropharyngeal) SCCs.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Chromosome Fragile Sites. Gene Expression Profiling. Oropharyngeal Neoplasms / genetics. Tongue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Primers. Female. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18758160.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA Primers
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74. Lam L, Logan RM, Luke C: Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001. Aust Dent J; 2006 Mar;51(1):16-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001.
  • BACKGROUND: Tongue cancer (141 ICD-9) is the most common intra-oral malignancy in Western countries.
  • In recent decades, reported tongue cancer incidence and mortality rates have increased both in Europe and in the United States, whilst survival has not improved.
  • This study aimed to determine the epidemiology and survival trends of tongue cancer in South Australia over the 24-year period from 1977 to 2001.
  • METHODS: Population-based data for tongue cancer were provided by the Central Cancer Registry Unit of the Epidemiology Branch of the South Australian Department of Health.
  • Kaplan-Meier survival analysis was conducted according to time periods, age, sex and tongue sub-sites.
  • RESULTS: During this 24-year period, 611 cases of tongue cancer (398 males, 213 females) were reported, the majority of which were squamous cell carcinomas.
  • The most common age of diagnosis was 65-69 years in males and 60-64 years in females.
  • Fifty cases (8.18 per cent of all tongue cancer cases) occurred in patients 40 years or younger.
  • The most common cancer sub-sites reported were 'unspecified site' (48.45 per cent), lateral border (25.53 per cent) and base (18.49 per cent) of the tongue.
  • The age-standardized incidence and mortality rates for males and females in South Australia were relatively low and stable, and there was no significant improvement in survival of tongue cancer over this period.
  • Significant predictors for survival were sex, age and tongue sub-sites, with male, advanced age and base of tongue associated with poorer survival.
  • CONCLUSIONS: Tongue cancer is an important health issue associated with poor survival.
  • Early detection and diagnosis is important in order to improve survival rate for this malignancy.
  • [MeSH-major] Tongue Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Factors. Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / mortality. Epidemiologic Studies. Female. Forecasting. Humans. Incidence. Male. Middle Aged. Population Surveillance. Prognosis. Proportional Hazards Models. Sex Factors. South Australia / epidemiology. Survival Rate

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  • (PMID = 16669472.001).
  • [ISSN] 0045-0421
  • [Journal-full-title] Australian dental journal
  • [ISO-abbreviation] Aust Dent J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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75. Diapera MJ, Lozon CL, Thompson LD: Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases. Am J Otolaryngol; 2009 Mar-Apr;30(2):101-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases.
  • BACKGROUND: Extra-urogenital tract malacoplakia is uncommon, with tongue malacoplakia being exceptionally rare.
  • MATERIALS AND METHODS: Five case reports of tongue malacoplakia were compiled from the literature (MedLine 1960-2008) and integrated with this case report.
  • The base of the tongue was the most frequent site, although midline tongue and half of the tongue were also affected.
  • These findings support a diagnosis of malacoplakia.
  • The differential diagnosis includes granular cell tumor, poorly differentiated carcinoma, and Langerhans histiocytosis.
  • CONCLUSIONS: Tongue malacoplakia is rare, often presenting as a mass lesion.
  • Histologic recognition of this abnormal phagocytic disorder will prevent potentially disfiguring surgery.
  • [MeSH-major] Malacoplakia / pathology. Tongue Diseases / pathology

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  • (PMID = 19239951.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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76. Minicucci EM, da Silva GN, Ribeiro DA, Favero Salvadori DM: No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. J Mol Histol; 2009 Feb;40(1):71-6
Hazardous Substances Data Bank. 4-NITROQUINOLINE-N-OXIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
  • The medium-term tongue carcinogenesis assay is a useful model for studying oral squamous cell carcinomas phase by phase.
  • The present study aimed to investigate mutations in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO) using direct DNA-sequencing method.
  • No histopathological changes in tongue epithelia were observed among controls or in the group treated for 4 weeks with 4NQO.
  • At 20 weeks, the tongue presented moderate and/or severe oral dysplasia and squamous cell carcinoma, with squamous cell carcinoma in the majority of animals.
  • Taken together, our results suggest that p16CDKN2A mutations in exon 2 are not involved in the multistep tongue carcinogenesis of Wistar rats induced by 4NQO.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Exons / genetics. Mutation. Tongue Neoplasms / genetics
  • [MeSH-minor] 4-Nitroquinoline-1-oxide. Animals. Base Sequence. DNA Mutational Analysis. Male. Molecular Sequence Data. Rats. Rats, Wistar

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  • (PMID = 19255859.001).
  • [ISSN] 1567-2387
  • [Journal-full-title] Journal of molecular histology
  • [ISO-abbreviation] J. Mol. Histol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 56-57-5 / 4-Nitroquinoline-1-oxide
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77. Hong Y, Yang L, Li C, Xia H, Rhodus NL, Cheng B: Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. Mol Carcinog; 2007 Feb;46(2):85-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
  • In this study we explored the mutation types of p16(CDKN2A) exon 1 and the corresponding frequencies in experimental rat tongue carcinogenesis.
  • Two samples of normal, three samples of moderate/severe dysplasia and four samples of invasive squamous cell carcinoma lesions were selected following strict histopathological examination in double-blind manner.
  • These preliminary results suggested that mutation of p16(CDKN2A) exon 1 might be an early molecular event of rat tongue carcinogenesis induced by 4NQO and G was the mutation hotspot.
  • [MeSH-major] 4-Nitroquinoline-1-oxide / toxicity. Carcinogens / toxicity. Cell Transformation, Neoplastic / genetics. Exons. Genes, p16. Mutation. Tongue Neoplasms / chemically induced
  • [MeSH-minor] Animals. Base Sequence. DNA. Male. Molecular Sequence Data. Polymerase Chain Reaction. Rats. Rats, Sprague-Dawley

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 17091472.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 56-57-5 / 4-Nitroquinoline-1-oxide; 9007-49-2 / DNA
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78. Lam L, Logan RM, Luke C, Rees GL: Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004. Oral Oncol; 2007 Feb;43(2):150-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004.
  • This is a retrospective study of patients with oral and oropharyngeal tongue cancers who presented to the Royal Adelaide Hospital (RAH) from 1987 to 2004.
  • All cases of tongue cancers, including untreated and palliative cases, were identified through the Royal Adelaide Hospital Cancer Registry and were included in statistical analysis.
  • A total of 212 cases of tongue cancer were identified.
  • Squamous cell carcinoma was the most common histological type.
  • Almost 30% of recorded cases were oropharyngeal or base of tongue cancers.
  • Nearly half of the patients had advanced stage (III and IV) disease at presentation, which was significantly associated with rural area of residence, base of tongue sub-site and early diagnostic period.
  • Palliative treatment was more likely to be given to patient with oropharyngeal tongue cancers or advance stage disease.
  • Poorer survival was significantly associated with age 45 years or older, oropharyngeal tongue cancers and advanced stage disease.
  • Tongue cancer is an important health issue associated with poor survival.
  • Early detection and diagnosis is important in order to improve survival rate for this malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Oropharyngeal Neoplasms / therapy. Tongue Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Epidemiologic Methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palliative Care / utilization. Prognosis. Treatment Outcome

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  • (PMID = 16807069.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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79. Zhao Y, Liu YH, Mei JY, Lu DH, Wu J, Ma YX, Yang KL: [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jul;45(7):582-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root].
  • OBJECTIVE: To investigate the surgical technique which could preserve the swallowing and laryngeal function effectively in the malignant head and neck tumors involving the tongue root.
  • METHODS: From January 2003 to December 2008, 31 cases of malignant head and neck tumors involving the tongue base had been treated in this hospital were retrospectively analyzed.
  • There were 27 males and 4 females in which 9 cases of primary malignant tumor were from the base of tongue; 3 cases were from the tonsil, 11 cases were from supraglottic laryngeal carcinoma and 8 cases were from hypopharyngeal carcinoma.
  • Preserved the lingual artery of the reserved side and the normal tissue of the root of tongue according to the clinical anatomy of lingual artery during the operation.
  • RESULTS: In this group, residual tongue necrosis did not occurred.
  • Two cases with hypopharyngeal carcinoma developed fistula, which were cured by dressing change.
  • Two with root of tongue cancer and 1 with tonsil cancer had postoperative infection and healed in 2 weeks.
  • CONCLUSIONS: In the surgical treatments of the malignant head and neck tumors involving the base of tongue, the excisions and reconstructions of the primary tumor and the involved tongue base according to the clinical anatomy of lingual artery and the protection mechanisms of laryngeal function during the operation was one of the most effective technique to preserve the swallowing and laryngeal function.
  • [MeSH-major] Glossectomy / methods. Head and Neck Neoplasms / surgery. Tongue Neoplasms / surgery

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  • (PMID = 21055059.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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80. Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X: MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochem J; 2010 Nov 15;432(1):199-205
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells.
  • However, the mechanism(s) by which miR-7 suppresses tumorigenesis in TSCC (tongue squamous cell carcinoma) is unknown.

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  • (PMID = 20819078.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NCI NIH HHS / CA / R01 CA139596-03; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / CA139596-03; United States / NIDCR NIH HHS / DE / K22 DE014847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / MIRN7 microRNA, human; 0 / MicroRNAs; 0 / RNA, Messenger; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.13.12.- / Luciferases; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Other-IDs] NLM/ NIHMS302690; NLM/ PMC3130335
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81. Kennedy TL, Riefkohl WL: Lingual thyroid carcinoma with nodal metastasis. Laryngoscope; 2007 Nov;117(11):1969-73
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  • [Title] Lingual thyroid carcinoma with nodal metastasis.
  • OBJECTIVES: To discuss treatment options and surgical management of lingual thyroid carcinoma with cervical metastasis.
  • STUDY DESIGN: Lingual thyroid is relatively uncommon, and carcinoma of the lingual thyroid is extremely rare, with only 40 cases reported.
  • We report a new case of a young female who presented with a cervical neck mass found to represent metastatic papillary thyroid carcinoma.
  • Further workup revealed the patient's only thyroid tissue was located at the tongue base and was the site of the primary tumor.
  • Management of lingual thyroid carcinoma and review of the literature is discussed.
  • METHODS: A case report and review of the literature of lingual thyroid carcinoma.
  • RESULTS: A young female presented with a left neck mass diagnosed as metastatic papillary thyroid carcinoma.
  • Review of the computed tomography scan of the neck revealed a tongue base mass, absence of an othotopic thyroid gland and bilateral cervical lymphandenopathy.
  • Bilateral selective neck dissections with removal of the tongue base lesion confirmed the diagnosis of lingual thyroid carcinoma with multiple left cervical nodal metastases.
  • CONCLUSIONS: A case of lingual papillary thyroid carcinoma with cervical metastasis is reported.
  • Surgical approaches to the tongue base need to be considered based on the size of the lingual primary tumor and the need to address lymph node metastases gland.
  • This is the first reported case in the literature of lingual papillary thyroid carcinoma presenting with cervical nodal metastasis in a female with absence of an orthotopic thyroid gland.
  • This is also the first report to show that papillary and not follicular cell carcinoma is the predominating histopathology in lingual thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary / surgery. Lymph Nodes / pathology. Thyroid Neoplasms / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis

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  • (PMID = 17828053.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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82. Millwaters M, Khan N, Halfpenny W: Simultaneous lymphoma and squamous cell carcinoma presenting as a neck lump. Br J Oral Maxillofac Surg; 2008 Mar;46(2):144-5
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  • [Title] Simultaneous lymphoma and squamous cell carcinoma presenting as a neck lump.
  • We describe the unusual presentation of a patient with simultaneous follicular lymphoma and metastatic head and neck squamous cell carcinoma.
  • This revealed squamous cell carcinoma arising from the left tongue base with metastatic disease in the left neck.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Lymphoma, Follicular / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lymphatic Metastasis. Male. Positron-Emission Tomography. Tomography, X-Ray Computed. Tongue Neoplasms / pathology. Ultrasonography

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  • (PMID = 17321646.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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83. Liu W, Gnepp DR, de Vries E, Bibawy H, Solomon M, Gloster ES: Mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum: a case report. Head Neck Pathol; 2009 Mar;3(1):59-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum: a case report.
  • Three cases of malignant transformation of sialadenoma papilliferum have been described in the literature.
  • We report a high grade mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum, at the base of the tongue, an unusual location for minor salivary gland neoplasms.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 20596992.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807533
  • [Keywords] NOTNLM ; Mucoepidermoid carcinoma / Salivary gland / Sialadenoma papilliferum
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84. Yaday S, Singh I, Singh J, Aggarwal N: Medullary carcinoma in a lingual thyroid. Singapore Med J; 2008 Mar;49(3):251-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medullary carcinoma in a lingual thyroid.
  • Total ectopia of thyroid is a rare phenomenon and malignant change in an ectopic thyroid is even rarer.
  • We report a case of medullary carcinoma in a total ectopic lingual thyroid occurring in a 45-year-old woman who presented with dysphagia, plummy voice and a round sessile mass at the base of the tongue.
  • Upon examination, it was found to be medullary carcinoma in an ectopic thyroid.
  • There is a need to investigate for an ectopic thyroid, or even total ectopia, in the case of any smooth mass found at the base of the tongue.
  • [MeSH-major] Carcinoma, Medullary / diagnosis. Lingual Thyroid / diagnosis. Thyroid Gland / abnormalities. Thyroid Neoplasms / diagnosis. Tongue / abnormalities

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  • (PMID = 18363009.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 9007-12-9 / Calcitonin
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85. El-Mofty SK, Patil S: Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):339-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype.
  • We have recently shown that HPV-positive tonsillar carcinoma in young patients exhibits nonkeratinizing basaloid morphology and a characteristic immunophenotype.
  • A total of 235 carcinomas were reviewed; 141 of the tonsils and 94 in the base of tongue.
  • Ninety (36%) of the tonsillar and 30 (32%) of the base of tongue carcinomas were nonkeratinizing (NKCa) with basal cell features; the rest were classical keratinizing squamous cell carcinomas (KSCC).
  • It is concluded that NKCa of the tonsils and base of tongue is a distinct subtype of squamous cell carcinoma of the head and neck with high prevalence of HPV DNA and a characteristic immunophenotype.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Oropharyngeal Neoplasms / virology. Papillomavirus Infections / pathology. Tongue Neoplasms / virology

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  • (PMID = 16504868.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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86. Xie J, Dong P, Jin B, Li KY, Wang J, Tu LQ, Zhang J: [Mandibular swing procedure for surgical resection of advanced oropharyngeal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):302-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mandibular swing procedure for surgical resection of advanced oropharyngeal carcinoma].
  • OBJECTIVE: To explore a better approach to resect the advanced oropharyngeal carcinoma.
  • METHODS: From 1995 to 2005, 17 patients underwent mandibular swing procedure for excision of advanced oropharyngeal carcinoma including: 13 tonsillar cancers, 2 soft palate carcinomas and 2 lingual root cancers.
  • Immediate reconstruction of the surgical defect was done using tongue flap, pectoralis major myocutaneous flap, sternohyoid myofascial flap, temporalis myofascial flap and forehead flap, respectively.
  • RESULTS: All patients' advanced oropharyngeal carcinoma were successfully resected as planned through the mandibular swing procedure or its combined procedures without severe complications.
  • CONCLUSION: The mandibular swing procedure and its combined approach is safe and effective in the surgical resection of the advanced oropharyngeal carcinoma, which can provide a good exposure for the oropharynx, supraglottic region, hypopharynx, the parapharyngeal space and the base of the skull.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mandible / surgery. Oropharyngeal Neoplasms / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Radiotherapy, Adjuvant. Survival Analysis

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  • (PMID = 17760261.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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87. Firat Y, Aygenç E, Firat AK, Oto A, Selçuk A, Firat MM, Ozdem C: Computed tomography virtual laryngoscopy: comparison between radiological and otolaryngological evaluations for laryngeal carcinoma. Kulak Burun Bogaz Ihtis Derg; 2006;16(3):97-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Computed tomography virtual laryngoscopy: comparison between radiological and otolaryngological evaluations for laryngeal carcinoma.
  • PATIENTS AND METHODS: Virtual laryngoscopic images were obtained from axial CT scans of 21 patients with known laryngeal carcinoma.
  • RESULTS: Lesions localized in the base of the tongue, pyriform sinus, aryepiglottic folds, and arytenoids were well visualized by both RTV and CTVL.
  • It may be beneficial in staging larynx carcinoma and planning the most appropriate surgical procedure.
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Processing, Computer-Assisted / methods. Male. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 16763426.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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88. Alkan S, Coskun BU, Ugur S, Başak T, Dadas B: Basaloid squamous cell carcinoma of the larynx. Auris Nasus Larynx; 2006 Mar;33(1):71-4
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  • [Title] Basaloid squamous cell carcinoma of the larynx.
  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor with distinct morphological and biological features that differentiate it from the common form of squamous cell carcinoma (SCC) in the head and neck region.
  • It is mostly seen in the supraglottic larynx, hypopharynx and a base of the tongue.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16188414.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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89. Liu B, Pan Z, Ji W: [Remaining laryngeal flap reconstruction of the hypopharynx in pyriform sinus carcinoma resection]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Mar;20(6):241-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Remaining laryngeal flap reconstruction of the hypopharynx in pyriform sinus carcinoma resection].
  • OBJECTIVE: To discuss the feasibility of using remaining laryngeal flap to reconstruct the hypopharyngeal defect in pyriform sinus carcinoma resection.
  • METHOD: Seven patients with pyriform sinus carcinoma to reconstruct hypopharyngeal defect with remaining laryngeal flap were summarized.
  • A 4.0 cm x 2.0 cm laryngeal flap was made with a broad base on the base of tongue.
  • The food canal was reconstructed with the pulled-down mucosa of the base of the tongue, the unaffected half of the larynx and the remnant hypopharyngeal mucosa.
  • CONCLUSION: To the selected cases with pyriform sinus carcinoma, reconstruction of hypopharyngeal defect with laryngeal flap is simple and safe.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Hypopharynx / surgery. Larynx / surgery

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  • (PMID = 16739372.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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90. Munck K, Ali MJ, Murr AH, Goldberg AN: Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma. Laryngoscope; 2005 Jul;115(7):1283-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma.
  • OBJECTIVE: To examine the impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring cancers by comparing the experience of a public hospital and an academic tertiary care medical center.
  • PATIENTS: One hundred seven patients with Waldeyer's ring carcinoma who were diagnosed and treated at San Francisco General Hospital (SFGH) or at the University of California, San Francisco Medical Center (UCSFMC) from January 1995 through December 2000 were included in the study.
  • Patients included in the study had a histologic diagnosis of Waldeyer's ring carcinoma, primary treatment with radiation, and no prior treatment of Waldeyer's ring carcinoma.
  • MAIN OUTCOME MEASURES: The time of diagnosis to start of radiation therapy, dose of radiation, number of treatment days, duration of treatment, and 1 and 3 year survival were recorded.
  • RESULTS: The time course from diagnosis of nasopharyngeal carcinoma to start of radiation therapy was 56 days at SFGH compared with 34 days at UCSFMC.
  • Difference in diagnosis to treatment intervals for base of tongue cancer was also significant at 66 days at SFGH compared with 31 days at UCSFMC (P = .0038).
  • For cancer of the tonsil, the diagnosis to treatment interval was 70 days at SFGH versus 40 days at UCSFMC (P = .0005).
  • [MeSH-major] Carcinoma / pathology. Carcinoma / radiotherapy. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / pathology. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Academic Medical Centers. Biopsy. California. Follow-Up Studies. Hospitals, Public. Humans. Neoplasm Staging. Radiotherapy / statistics & numerical data. Retrospective Studies. Socioeconomic Factors. Survival Rate. Time Factors

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  • (PMID = 15995522.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Adelson RT, Ducic Y: Metastatic head and neck carcinoma to a percutaneous endoscopic gastrostomy site. Head Neck; 2005 Apr;27(4):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic head and neck carcinoma to a percutaneous endoscopic gastrostomy site.
  • In the case at our institution, a 63-year-old man was referred to our institution with recurrent squamous cell carcinoma of the right base of tongue; he also had a 1.5-cm left apical lung nodule.
  • Six months after the original tube placement, he had an ulcerated mass develop at the PEG site; biopsy of the mass revealed squamous cell carcinoma histologically identical to the base of tongue tumor.
  • CONCLUSIONS: PEG site metastases are iatrogenic complications of PEG tube placement in patients with squamous cell carcinoma of the upper aerodigestive tract.
  • The use of laparoscopic, open, or the "push" technique of PEG tube placement in patients with head and neck cancer may prevent direct implantation of malignant cells into an enteral access site.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Enteral Nutrition. Gastroscopy. Gastrostomy. Muscle Neoplasms / secondary. Rectus Abdominis / pathology. Stomach Neoplasms / secondary. Tongue Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 15712297.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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92. Jo VY, Mills SE, Stoler MH, Stelow EB: Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol; 2009 Nov;33(11):1720-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma.
  • Papillary squamous cell carcinoma (SCC) is an uncommon variant of SCC in the upper aerodigestive tract.
  • As with other HPV-associated SCCs of the upper aerodigestive tract, the majority of HPV-associated papillary SCCs are oropharyngeal (base of tongue and palatine tonsils), although both sinonasal and laryngeal tumors were also associated with infection (67% and 33% of cases, respectively).
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma, Papillary / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Papillomavirus Infections / pathology
  • [MeSH-minor] Adult. Aged. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. DNA, Viral / analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 19745700.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
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93. Kutter J, Ozsahin M, Monnier P, Stupp R: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):1-7
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  • [Title] Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma.
  • Twenty-three patients (median age: 54 years, range: 35-70) with locally advanced squamous cell carcinoma of the head and neck (SCCHN) were included.
  • The primary tumor involved the hypopharynx (n=7), base of the tongue (n=10), nasopharynx (n=2) or upper esophagus (n=1) or its location was unknown (n=3).
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / drug therapy. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Amifostine / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage

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  • (PMID = 15004704.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] M487QF2F4V / Amifostine; Q20Q21Q62J / Cisplatin
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94. Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope; 2006 Jul;116(7):1148-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck.
  • OBJECTIVES: This study sought to investigate the patterns and distributions of lymph node metastases in oropharyngeal squamous cell carcinoma (SCC) and improve the rationale for elective treatment of N0 neck.
  • The incidence rate of level IV metastasis in patients with ipsilateral nodal metastasis was significantly higher in base of tongue cancer (86% [6 of 7]) compared with tonsillar cancer (34% [20 of 59]) (P=.013).
  • CONCLUSION: These results suggest that elective N0 neck treatment in patients with oropharyngeal SCC, especially base of tongue cancer, should include neck levels II, III, and IV instead of levels I, II, and III.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Oropharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Neck Dissection. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 16826050.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Cakli H, Altin F, Ak I, Gürbüz MK, Ozüdoğru E: [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report]. Kulak Burun Bogaz Ihtis Derg; 2005;14(1-2):39-43
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  • [Title] [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report].
  • He had previously undergone a neck biopsy, the result of which had been reported as metastatic carcinoma.
  • Investigation with positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose suggested the base of the tongue as the primary site, which was then confirmed by an endoscopic biopsy from the tongue.
  • It should be borne in mind that positron emission tomography may be helpful in the diagnosis of unknown primary tumors with cervical metastasis.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Neoplasms, Unknown Primary / diagnosis. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / radiography. Neoplasms, Unknown Primary / surgery. Positron-Emission Tomography

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  • (PMID = 16227723.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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96. Donta TS, Smoker WR: Head and neck cancer: carcinoma of unknown primary. Top Magn Reson Imaging; 2007 Aug;18(4):281-92
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head and neck cancer: carcinoma of unknown primary.
  • Carcinoma of unknown primary is uncommon, estimated to represent only 3% to 5% of all head and neck cancers.
  • Squamous cell carcinoma accounts for 70% to 90% of these lesions, most commonly from sites in the upper aerodigestive tract, including tonsils, base of tongue, nasopharynx, and piriform sinus.
  • Magnetic resonance and CT are both used for evaluation for extracapsular nodal disease, perineural tumor spread, osseous skull base or perivertebral space involvement, and vascular invasion, findings that seriously impact treatment and prognosis.
  • [MeSH-major] Carcinoma / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 17893593.001).
  • [ISSN] 0899-3459
  • [Journal-full-title] Topics in magnetic resonance imaging : TMRI
  • [ISO-abbreviation] Top Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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97. Badakhshi H, Marnitz S, Scherer H, Budach V, Haisch A: [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences]. HNO; 2008 Mar;56(3):328-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences].
  • We report on a safe and effective salvage option in the treatment of adenoid cystic carcinoma.
  • MATERIAL AND METHODS: A 44 year old woman with the diagnosis of adenoid cystic carcinoma of the oropharynx and simultaneous pulmonary metastases received a mixed beam photon radiotherapy and a neutron boost.
  • A local recurrence in the base of tongue and floor of mouth was histologically confirmed.
  • CONCLUSION: HDR-Ir brachytherapy is an effective method for the treatment of local recurrences of an adenoid cystic carcinoma, even after preradiotherapy.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Adenoid Cystic / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Oropharyngeal Neoplasms / radiotherapy

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  • (PMID = 18288466.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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98. Nakamura T, Kodaira T, Tachibana H, Tomita N, Yokouchi J, Fuwa N: Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy. Oral Oncol; 2009 Sep;45(9):830-4
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  • [Title] Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy.
  • To determine the efficacy, feasibility, and toxicity of treated with platinum-based chemoradiotherapy for oropharyngeal carcinoma.
  • Nine patients who had a tumor in the base of the tongue were also treated with arterial infusion chemotherapy.
  • The 5-year local control rate for each subsite was: anterior wall, 90%; lateral wall, 80%; posterior wall, 67%; and superior wall, 64%.
  • In this study, platinum-based chemoradiotherapy provided good local control for oropharyngeal carcinoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy / methods. Disease-Free Survival. Feasibility Studies. Female. Fluorouracil / administration & dosage. Humans. Japan. Male. Middle Aged. Neoplasm Recurrence, Local. Organoplatinum Compounds / administration & dosage. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 19457713.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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99. Lim YC, Hong HJ, Baek SJ, Park JH, Kim GE, Lee CG, Lew DH, Lee WJ, Choi EC: Combined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases. Int J Oral Maxillofac Surg; 2008 Dec;37(12):1099-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases.
  • The treatment of oropharyngeal squamous cell carcinoma (OSCC) remains controversial.
  • The DSSR of the soft palate or posterior pharyngeal wall, tonsillar area, and base of tongue were 80%, 62%, and 51%, respectively (P<0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neoadjuvant Therapy. Oropharyngeal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Korea. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck / pathology. Neck Dissection. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Palate, Soft / radiation effects. Palate, Soft / surgery. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy. Survival Rate. Tongue Neoplasms / radiotherapy. Tongue Neoplasms / surgery. Tonsillar Neoplasms / radiotherapy. Tonsillar Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18722091.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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100. Shin HA, Lim YC, Jeong HM, Choi EC: Role of primary surgery for early-stage (T1-2N0) squamous cell carcinoma of the oropharynx. Oral Oncol; 2009 Dec;45(12):1063-6
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  • [Title] Role of primary surgery for early-stage (T1-2N0) squamous cell carcinoma of the oropharynx.
  • To evaluate treatment outcomes and the role of primary definitive surgery for T(1-2), clinically N(0) oropharyngeal squamous cell carcinoma (OPSCC) patients, we performed a retrospective analysis of 46 consecutive cases treated primarily by surgery and/or postoperative radiotherapy at Yonsei University between May 1992 and December 2006.
  • The most common location was the tonsil (54%), followed by the soft palate (19%), the base of the tongue (BOT) (15%) and the posterior wall (12%).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Oropharyngeal Neoplasms / surgery

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  • (PMID = 19717331.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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