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6. Wakisaka N, Murono S, Minato H, Furukawa M, Yoshizaki T: A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base. Auris Nasus Larynx; 2006 Dec;33(4):487-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base.
  • Here, we report on a case of undifferentiated carcinoma of the tongue base.
  • A 71-year-old male, who had been treated with irradiation for primary unknown right neck metastatic EBV-positive undifferentiated carcinoma 9 years previously, was referred to our clinic with masses at the tongue base and right neck.
  • The lesion at the tongue base was revealed to be an EBV-positive undifferentiated carcinoma.
  • He was treated with resection of tongue base tumor and bilateral-neck dissection, and the defect at the tongue base was reconstructed with a free rectus abdominis myocutaneous flap.
  • Re-irradiation was added post-operatively because of a positive surgical margin at the tongue base.
  • [MeSH-major] Carcinoma / virology. Herpesviridae Infections / complications. Herpesvirus 4, Human / isolation & purification. Tongue Neoplasms / virology. Tumor Virus Infections / complications

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  • (PMID = 16934421.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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7. Deleyiannis FW, Lee E, Gastman B, Nguyen D, Russavage J, Manders EK, Ferris RL, Myers EN, Johnson J: Prognosis as a determinant of free flap utilization for reconstruction of the lateral mandibular defect. Head Neck; 2006 Dec;28(12):1061-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Age >or=70 years (p = .03), moderate or severe comorbidity (p = .02), and involvement of the base of tongue by tumor (p = .04) were significantly associated with decreased utilization of a free flap (n = 36).
  • [MeSH-major] Carcinoma / diagnosis. Head and Neck Neoplasms / diagnosis. Mandible / surgery. Reconstructive Surgical Procedures / methods. Sarcoma / diagnosis. Surgical Flaps


8. Silva P, Slevin NJ, Sloan P, Valentine H, Cresswell J, Ryder D, Price P, Homer JJ, West CM: Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1551-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer.
  • Currently most management decisions are based on clinical parameters with little appreciation of patient differences in underlying tumor biology.
  • We investigated the prognostic significance of clinicopathologic features and tumor hypoxia-inducible factor-1alpha (HIF-1alpha) expression in a homogeneous series of patients who underwent radiotherapy.
  • METHODS AND MATERIALS: An audit identified 133 consecutive patients with histologically proven squamous cell carcinoma of the tonsil or tongue base.
  • Tumor HIF-1alpha expression was examined in 79 patients.
  • 3.04-176.7) than the tongue-base tumor (HR, 2.86; 95% CI, 1.14-7.19) group (p = 0.03, test for interaction).
  • High tumor HIF-1alpha expression was associated with low blood Hb levels (p = 0.03).
  • The work highlights the importance of studying homogeneous groups of patients in HNSCC, and the complex interrelationships between tumor biology and clinicopathologic factors.
  • The establishment of tumor-type specific markers would represent a major advance in this area.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / radiotherapy. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / radiotherapy. Hemoglobins / metabolism. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Tongue Neoplasms / genetics. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / genetics. Tonsillar Neoplasms / radiotherapy. Treatment Outcome. Young Adult

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  • (PMID = 19028277.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hemoglobins; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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9. Adelson RT, Ducic Y: Metastatic head and neck carcinoma to a percutaneous endoscopic gastrostomy site. Head Neck; 2005 Apr;27(4):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the case at our institution, a 63-year-old man was referred to our institution with recurrent squamous cell carcinoma of the right base of tongue; he also had a 1.5-cm left apical lung nodule.
  • Six months after the original tube placement, he had an ulcerated mass develop at the PEG site; biopsy of the mass revealed squamous cell carcinoma histologically identical to the base of tongue tumor.
  • Direct implantation with a variable-sized initial tumor burden can explain all cases of PEG site metastasis.
  • Smaller initial tumor implants present later than would larger initial tumor burdens, when the patient is more likely to have distant metastatic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Enteral Nutrition. Gastroscopy. Gastrostomy. Muscle Neoplasms / secondary. Rectus Abdominis / pathology. Stomach Neoplasms / secondary. Tongue Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 15712297.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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10. Suzuki H, Katoh A, Udaka T, Shiomori T, Fujimura T, Fujimura K, Kitamura T: Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol; 2006 Jun;126(6):653-6
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  • [Title] Hyalinizing clear cell carcinoma arising from the base of the tongue.
  • Hyalinizing clear cell carcinoma is a low-grade indolent and rare salivary gland tumor originally described by Milchgrub et al. in 1994.
  • We herein report a case of this tumor of the base of the tongue.
  • Computed tomography and magnetic resonance imaging revealed a 40x30-mm well-defined ovoid tumor arising from the base of the tongue.
  • She underwent tracheostomy followed by a resection of the tumor via the transmandibular approach combined with a right-sided supra-omohyoid neck dissection.
  • Because the tumor invasion of the surrounding tissue was limited, the surgical defect at the base of the tongue was relatively small, and no reconstructive procedure needed to be performed.
  • The tumor was histopathologically diagnosed as hyalinizing clear cell carcinoma of the minor salivary gland.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Hyalin. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laryngoscopy. Magnetic Resonance Imaging. Neck Dissection. Stromal Cells / pathology. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 16720452.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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11. El Kohen A, Essakalli L, Kzadri M, Sefiani S, Seffar Andaloussi Z: [Pleomorphic adenoma of the tongue base]. Rev Stomatol Chir Maxillofac; 2007 Jun;108(3):215-7
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  • [Title] [Pleomorphic adenoma of the tongue base].
  • [Transliterated title] Adénome pléomorphe de la base de langue.
  • INTRODUCTION: Pleomorphic adenoma is the most common lesion of minor salivary glands but is exceptional in the tongue base.
  • REPORT CASE: We report the case of a 70-year-old woman with pleomorphic adenoma of the tongue base.
  • Physical examination and computed tomography revealed a cystic tumour located in the right side of tongue base.
  • The tumor was removed by transoral resection.
  • DISCUSSION: We will discuss the diagnostic and therapeutically modalities of pleomorphic adenoma of the tongue base with a review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17459439.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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12. Tixier H, Fraisse J, Bruchon Y, Cuisenier J: [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath]. J Chir (Paris); 2009 Oct;146(5):503-5
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  • [Title] [Metastatic tumor implantation from a primary cancer of the base of the tongue at the site of placement of a central venous portacath].
  • [Transliterated title] Métastase d'une tumeur de la base de langue sur un système d'accès veineux central totalement implantable.
  • We report a case of metastatic implantation at a port site from a primary cancer of the base of the tongue.
  • Insertion of portacaths must be performed using full sterile precautions to avoid spread of tumor cells; in no case should the port site incisions be in contact with the surgical field in which the tumor resection was performed.
  • [MeSH-major] Carcinoma, Squamous Cell. Catheterization, Central Venous / adverse effects. Infusion Pumps, Implantable / adverse effects. Oropharyngeal Neoplasms. Tongue Neoplasms
  • [MeSH-minor] Aged. Biopsy. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Positron-Emission Tomography. Skin Neoplasms / secondary. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19833338.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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13. Lee N, Jensen J, Schoder H, Wang Y, Fury M, Pfister DG, Stambuk H, Humm J, Koutcher J, Shukla-Dave A: Correlation of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) with <sup>18</sup>f-fluoromisonidazole positron emission and computed tomography (<sup>18</sup>F-FMISO PET/CT) in assessing tumor hypoxia in a series of head and neck cancer (HNC) patients with nodal metastases. J Clin Oncol; 2009 May 20;27(15_suppl):6083

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) with <sup>18</sup>f-fluoromisonidazole positron emission and computed tomography (<sup>18</sup>F-FMISO PET/CT) in assessing tumor hypoxia in a series of head and neck cancer (HNC) patients with nodal metastases.
  • Hypoxia can develop within the tumor which typically corresponds to regions with poor blood perfusion.
  • DCE-MRI can yield results on tumor perfusion.
  • METHODS: 13 HNC (7 base of tongue, 5 tonsil, 1 larynx) patients with nodal metastases underwent both DCE-MRI and <sup>18</sup>F-FMISO PET/CT scans prior to chemoradiotherapy.
  • <sup>18</sup>F-FMISO PET/CT images were analyzed and the uptake by the tumor was scored as: no uptake (score 0); moderate-severe uptake (score 1).

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  • (PMID = 27961949.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Briem B, Magnúsdóttir AB: [Lingual thyroid--case report: a woman with a tumor at the base of the tongue]. Laeknabladid; 2005 Sep;91(9):661-3

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  • [Title] [Lingual thyroid--case report: a woman with a tumor at the base of the tongue].
  • Laryngostroboscopy showed a mass lesion at the base of the tongue.
  • On examination a mass is noted at the base of the tongue and the diagnosis is then confirmed with CT/MRI and thyroid scanning.

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  • (PMID = 16155337.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Iceland
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15. Konsulov SS: Carcinoma of the tongue base. Folia Med (Plovdiv); 2005;47(3-4):24-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the tongue base.
  • AIM: This study reports the results of surgical treatment of patients with carcinoma of the base of tongue-supraglottic complex.
  • The base of the tongue, the epiglottic valleculae, preepiglottic space and supraglottic part of the larynx develop from one central region.
  • The proper term to refer to these structures is tongue base-supraglottic complex.
  • METHODS: Patients with squamous-cell carcinoma of the tongue base present usually in advanced stage of the disease.
  • All patients underwent supraglottic laryngectomy through suprahyoid pharyngectomy and extended resection of the tongue base that allowed sufficient visualization of the tumor.
  • RESULTS: Twenty-eight patients with carcinoma of the tongue base-supraglottic complex were treated in the Department of Ear, Nose and Throat Diseases of the Medical University Plovdiv between 2001 and 2004.
  • CONCLUSIONS: The supraglottic laryngectomy with suprahyoid pharyngectomy provides good exposure of the tumor in the area of the tongue base-supraglottic complex allowing thorough resection of the tumor and avoiding the functional and cosmetic defects characteristic of the combined method (mandibulotomy).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16761390.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bulgaria
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16. Hsu YC, Hwang CF, Hsu RF, Kuo FY, Chien CY: Schwannoma (neurilemmoma) of the tongue. Acta Otolaryngol; 2006 Aug;126(8):861-5
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  • [Title] Schwannoma (neurilemmoma) of the tongue.
  • CONCLUSION: Schwannoma of the tongue always presents as a painless mass on the lingual surface and exhibits no gender preference.
  • A schwannoma on the base of tongue is usually larger at presentation than one on the tongue itself, since it is asymptomatic initially.
  • OBJECTIVES: To describe the patient demographics, presenting signs and symptoms, tumor location, imaging studies, management, and therapeutic outcomes of schwannoma of the tongue, an uncommon tumor of neuroectodermal origin that may arise from any myelinated nerve fiber.
  • PATIENTS AND METHODS: In this retrospective study, records of 10 patients who underwent surgical removal of schwannomas of the tongue or base of the tongue between January 1988 and June 2005 were reviewed and summarized.
  • The locations of the schwannomas were as follows: four on the lateral border of the tongue, two on the tongue tip, one on the ventral side of the tongue, and three on the base of the tongue.
  • For all patients, no tumor recurrence or complication was noted after tumor extirpation.
  • [MeSH-major] Neurilemmoma / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 16846930.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / S100 Proteins
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17. Zhao Y, Liu YH, Mei JY, Lu DH, Wu J, Ma YX, Yang KL: [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jul;45(7):582-6
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  • [Title] [Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root].
  • OBJECTIVE: To investigate the surgical technique which could preserve the swallowing and laryngeal function effectively in the malignant head and neck tumors involving the tongue root.
  • METHODS: From January 2003 to December 2008, 31 cases of malignant head and neck tumors involving the tongue base had been treated in this hospital were retrospectively analyzed.
  • There were 27 males and 4 females in which 9 cases of primary malignant tumor were from the base of tongue; 3 cases were from the tonsil, 11 cases were from supraglottic laryngeal carcinoma and 8 cases were from hypopharyngeal carcinoma.
  • Preserved the lingual artery of the reserved side and the normal tissue of the root of tongue according to the clinical anatomy of lingual artery during the operation.
  • RESULTS: In this group, residual tongue necrosis did not occurred.
  • Two with root of tongue cancer and 1 with tonsil cancer had postoperative infection and healed in 2 weeks.
  • CONCLUSIONS: In the surgical treatments of the malignant head and neck tumors involving the base of tongue, the excisions and reconstructions of the primary tumor and the involved tongue base according to the clinical anatomy of lingual artery and the protection mechanisms of laryngeal function during the operation was one of the most effective technique to preserve the swallowing and laryngeal function.
  • [MeSH-major] Glossectomy / methods. Head and Neck Neoplasms / surgery. Tongue Neoplasms / surgery

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  • (PMID = 21055059.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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18. Takácsi-Nagy Z, Muraközy G, Pogány P, Fodor J, Orosz Z: Myofibroblastic sarcoma of the base of tongue. Case report and review of the literature. Strahlenther Onkol; 2009 Mar;185(3):198-201
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  • [Title] Myofibroblastic sarcoma of the base of tongue. Case report and review of the literature.
  • CASE REPORT: A 56-year-old woman with intermediate-grade myofibroblastic sarcoma of the base of tongue is presented.
  • She was treated with surgical excision, but computed tomography proved local residual tumor.
  • According to the review of the literature, base of tongue as the primary site of myofibroblastic sarcoma has not been published so far.
  • [MeSH-major] Myosarcoma / diagnosis. Myosarcoma / radiotherapy. Sarcoma / diagnosis. Sarcoma / radiotherapy. Tongue Neoplasms / diagnosis. Tongue Neoplasms / radiotherapy

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  • (PMID = 19330298.001).
  • [ISSN] 1439-099X
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
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19. Tezal M, Sullivan Nasca M, Stoler DL, Melendy T, Hyland A, Smaldino PJ, Rigual NR, Loree TR: Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. Arch Otolaryngol Head Neck Surg; 2009 Apr;135(4):391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic periodontitis-human papillomavirus synergy in base of tongue cancers.
  • OBJECTIVE: To assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in patients with base of tongue cancers.
  • PATIENTS: Thirty patients newly diagnosed with base of tongue squamous cell carcinoma between 1999 and 2005 for whom both tumor samples and periodontal records were available.
  • MAIN OUTCOME MEASURE: HPV-16 and HPV-18 DNA were identified on paraffin-embedded tumor samples by polymerase chain reaction.
  • After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold (odds ratio, 3.96; 95% confidence interval, 1.18-13.36) increased risk of HPV-positive tumor status.
  • Number of missing teeth was not associated with tumor HPV status (odds ratio, 0.95; 95% confidence interval, 0.74-1.21).
  • CONCLUSIONS: Chronic periodontitis may be a significant factor in the natural history of HPV infection in patients with base of tongue cancers.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Chronic Periodontitis / epidemiology. Human papillomavirus 16 / isolation & purification. Human papillomavirus 18 / isolation & purification. Tongue Neoplasms / virology

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  • (PMID = 19380363.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R03CA119262; United States / NIDCR NIH HHS / DE / T32-DE07034
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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20. Vidiri A, Ruscito P, Pichi B, Pellini R, Covello R, Sperduti I, Di Giovanni S, Spriano G, Crecco M: Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor. J Exp Clin Cancer Res; 2007 Dec;26(4):575-82
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  • [Title] Oral cavity and base of the tongue tumors. Correlation between clinical, MRI and pathological staging of primary tumor.
  • The diagnosis of oral cavity and oropharyngeal tumors can be obtained through clinical examination and biopsy.
  • The aim of this study was to define the accuracy of clinical and MRI T staging of oral cavity and base of the tongue tumors and correlate the results with pathological data.
  • [MeSH-major] Magnetic Resonance Imaging. Mouth Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Male. Mouth / pathology. Neoplasm Staging

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  • (PMID = 18365555.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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21. Pederson AW, Haraf DJ, Witt ME, Stenson KM, Vokes EE, Blair EA, Salama JK: Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head Neck; 2010 Nov;32(11):1519-27
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  • [Title] Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.
  • BACKGROUND: Our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy.
  • METHODS: Between 1990 and 2004, 127 patients with stage III or IV base of tongue cancer were treated with chemoradiotherapy on protocol.
  • The median dose to gross tumor was 72.5 Gy (range, 40-75.5 Gy).
  • CONCLUSION: Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Tongue Neoplasms / mortality. Tongue Neoplasms / therapy

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  • (PMID = 20187015.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Interferon-alpha; 0 / Recombinant Proteins; 2S9ZZM9Q9V / Bevacizumab; 7673326042 / irinotecan; 99210-65-8 / interferon alfa-2b; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; X6Q56QN5QC / Hydroxyurea; XT3Z54Z28A / Camptothecin
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22. Attner P, Du J, Näsman A, Hammarstedt L, Ramqvist T, Lindholm J, Marklund L, Dalianis T, Munck-Wikland E: The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer; 2010 Jun 15;126(12):2879-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of human papillomavirus in the increased incidence of base of tongue cancer.
  • Following our previous research on tonsillar cancer, we assessed the increase in the incidence of base of tongue cancer and the prevalence of HPV in this disease.
  • Between 1998 and 2007, 109 patients were diagnosed for base of tongue cancer in Stockholm county.
  • Ninety-five paraffin-embedded diagnostic tumor biopsies from patients were obtained and tested for HPV, both by general HPV PCR and HPV-16/HPV-33 type-specific PCR.
  • An overall increase in the incidence of base of tongue cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden.
  • The prevalence of HPV in base of tongue cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05).
  • The incidence of base of tongue cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / virology. Tongue Neoplasms / virology

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  • (PMID = 19856308.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Papillomavirus E7 Proteins; 0 / Repressor Proteins; 0 / oncogene protein E7, Human papillomavirus type 16
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23. Tincani AJ, Altemani A, Martins AS, Barreto G, Valério JB, Del Negro A, Araújo PP: Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location. Ear Nose Throat J; 2005 Dec;84(12):794-5, 799
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  • [Title] Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate.
  • We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck.
  • The tumor was resected through the oral cavity with wide margins and dissection.
  • [MeSH-major] Adenocarcinoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16408562.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Camp AA, Fundakowski C, Petruzzelli GJ, Emami B: Functional and oncologic results following transoral laser microsurgical excision of base of tongue carcinoma. Otolaryngol Head Neck Surg; 2009 Jul;141(1):66-9
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  • [Title] Functional and oncologic results following transoral laser microsurgical excision of base of tongue carcinoma.
  • OBJECTIVE: The study objective was to determine survival and functional results in patients who underwent transoral laser excision of base of tongue squamous cell carcinoma.
  • SUBJECTS AND METHODS: Patients with biopsy-proven base of tongue squamous cell carcinoma primarily treated with transoral laser excision and followed for at least 24 months were included.
  • RESULTS: Of the 71 patients treated, one (1.4%), nine (12.7%), seven (9.9%), and 54 (76.1%) were stage I, II, III, and IV, respectively, at diagnosis.
  • Given the low number of deaths, no significance was detectable between survival and gender, overall stage, tumor size, nodal status, or adjuvant therapy.
  • CONCLUSION: Transoral laser excision offers an acceptable treatment approach in terms of survival and quality of life for patients with base of tongue squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laser Therapy / methods. Tongue Neoplasms / surgery

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  • (PMID = 19559960.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Henstrom DK, Moore EJ, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1231-8
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  • [Title] Transoral resection for squamous cell carcinoma of the base of the tongue.
  • OBJECTIVE: To review the oncologic and functional outcomes of patients with squamous cell carcinoma of the base of the tongue who underwent transoral tumor resection and neck dissection with or without postoperative adjuvant therapy.
  • PATIENTS: All patients undergoing transoral resection of squamous cell carcinoma on the base of the tongue as part of their primary treatment from January 1, 1996, through January 31, 2005.
  • CONCLUSIONS: Transoral resection of squamous cell carcinoma of the base of the tongue with postoperative adjuvant therapy provided excellent local and regional control and minimized morbidity.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Enteral Nutrition. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 20026821.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Laccourreye O, Seccia V, Ménard M, Garcia D, Vacher C, Holsinger FC: Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base. Ann Otol Rhinol Laryngol; 2009 Jun;118(6):428-34
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  • [Title] Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base.
  • OBJECTIVES: In a retrospective review of an inception cohort of 26 patients with an isolated, previously untreated, moderately to well-differentiated invasive squamous cell carcinoma of the lateral tongue base, consecutively managed with an extended lateral pharyngotomy approach at a single tertiary referral care center, the authors review the key surgical points, highlight the potential technical pitfalls, and document the complications and long-term functional and oncological outcomes in terms of survival and local control.
  • The main causes of death were metachronous second primary tumor, intercurrent disease, and distant metastasis, resulting in 84.6%, 64%, and 46.9% 1-, 3-, and 5-year Kaplan-Meier actuarial survival estimates, respectively.
  • CONCLUSIONS: Such results suggest that extended lateral pharyngotomy should be integrated among the various conservative treatment options available to patients with selected carcinomas of the lateral tongue base.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neck Dissection / methods. Pharynx / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19663374.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Hirunpat S, Jongsatitpaiboon J, Angunsri N, Chowchuvech V: When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma? Asian Pac J Cancer Prev; 2007 Apr-Jun;8(2):310-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] When should MRI be recommended for the accurate clinical staging of base of tongue carcinoma?
  • BACKGROUND AND PURPOSE: According to the American Joint Committee on Cancer (AJCC) cancer staging criteria (6th edition), cross-sectional imaging for base of tongue carcinoma is recommended when the deep tissue extent of a primary tumor is in question.
  • The aim of this study was to establish which group of patients MRI might most benefit from accurate clinical staging of base of tongue carcinomas.
  • PATIENTS AND METHODS: The clinical stagings of 33 patients with pathologically proven squamous cell carcinomas of the base of tongue were performed by two otorhinolaryngologic surgeons.
  • RESULTS: The tumor stages were changed in 13 of 33 patients (39.4%, 95% CI: 23.9-57.87%) and the overall stage groupings were changed in 10 (30.3 %, 95%CI: 15.6-48.7%) after performing MRI.
  • CONCLUSION: MRI should be recommended in base of tongue carcinoma whenever clinical examination suggests overall stage groupings II, III or tumor stage T3.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Reproducibility of Results

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  • (PMID = 17696753.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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28. Kumai Y, Ogata N, Yumoto E: Epithelial-myoepithelial carcinoma in the base of the tongue: a case report. Am J Otolaryngol; 2006 Jan-Feb;27(1):58-60
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  • [Title] Epithelial-myoepithelial carcinoma in the base of the tongue: a case report.
  • OBJECTIVES: To report a rare case of epithelial-myoepithelial carcinoma (EMC) of a minor salivary gland originating in the base of the tongue, which is a highly unusual location.
  • Endoscopic examination revealed a tumorous lesion 40 x 20 mm in the base of the tongue on the left side.
  • The final diagnosis based on the histological and immunohistochemical findings was EMC.
  • Because neither histological evidence of residual tumor in the surgical margin nor neck metastases were found, radiotherapy was not performed.
  • CONCLUSION: We believe this report is the first description of EMC originating in the base of the tongue.
  • [MeSH-major] Carcinoma / pathology. Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Neoplasm Staging. Oral Surgical Procedures / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 16360826.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Hancock SB, Krempl GA, Canfield V, Bogardus C, Kojouri K, Kaneaster SK, Medina JE: Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. Laryngoscope; 2008 Aug;118(8):1357-61
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  • [Title] Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy.
  • OBJECTIVES/HYPOTHESIS: To assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage III and IV base of tongue cancer.
  • STUDY DESIGN: Subgroup analysis of patients with base of tongue cancer enrolled in a single-institution prospective phase II trial, evaluating an organ-preservation approach in the treatment of locally advanced head and neck cancer.
  • If the primary tumor exhibited a complete or partial response, patients were treated with radiation and weekly taxol and carboplatin for 7 weeks.
  • CONCLUSIONS: The treatment regimen studied is remarkably effective in stage III and IV base of tongue cancer with 100% of patients completing the protocol alive to date.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Disease-Free Survival. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Nervous System Diseases / chemically induced. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 18528311.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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30. Karakoyun-Celik O, Norris CM Jr, Tishler R, Mahadevan A, Clark JR, Goldberg S, Devlin P, Busse PM: Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base. Head Neck; 2005 May;27(5):353-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base.
  • BACKGROUND: The purpose of this study was to examine the long-term outcome of a cohort of patients with unresected base of tongue carcinoma who received interstitial brachytherapy after comprehensive external beam radiation therapy.
  • Forty patients had primary, unresected carcinoma of the base of tongue and are the subjects of this analysis.
  • The oropharynx, bilateral neck, and supraclavicular fossae were comprehensively irradiated, and the tongue base received a median external beam dose of 61.2 Gy (50-72 Gy).
  • The median implant dose was 17.4 Gy (9.6-24 Gy) and adjusted to reach a total dose to the primary tumor of 80 Gy.
  • The long-term data presented here support an approach of treating advanced tongue base lesions that includes interstitial brachytherapy as part of the overall management plan.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Squamous Cell / therapy. Tongue Neoplasms / therapy

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15726587.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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31. Windfuhr JP, Remmert S: Infrahyoid myofascial flap for tongue reconstruction. Eur Arch Otorhinolaryngol; 2006 Nov;263(11):1013-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infrahyoid myofascial flap for tongue reconstruction.
  • For selected cases, reconstruction of the tongue may be required after tumor removal.
  • This study was undertaken to demonstrate a simplified concept of tongue reconstruction with emphasis on infrahyoid myofascial flaps (IMF).
  • The defects of the tongue were classified in 23 patients according to the extent of tumor growth, functional and surgical aspects.
  • The oral tongue (OT; n = 1), base of tongue (BT; n = 12) or both areas (OT and BT; n = 10) were involved, with (n = 14) or without (n = 9) infiltration of adjacent tissues.
  • IMF serves as a reliable tool for minor or major reconstructive procedures of the tongue.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Otorhinolaryngologic Surgical Procedures / methods. Surgical Flaps. Tongue Neoplasms / surgery

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  • (PMID = 16868774.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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32. Lüers JC, Isfort P, Bovenschulte H, Beutner D: [Unilateral tongue atrophy and articulation difficulties]. HNO; 2010 Jan;58(1):68-71
MedlinePlus Health Information. consumer health - Tongue Disorders.

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  • [Title] [Unilateral tongue atrophy and articulation difficulties].
  • She reported that her tongue felt "heavy and inert".
  • Clinically, right-sided atrophy of the tongue and deflection of the tongue to the right were observed.
  • On CT, a bone-destroying process was seen in the area of the right lateral skull base, which reached as far as the internal carotid artery.
  • MRI demonstrated atrophy of the right tongue musculature with fatty degeneration, as well as an oval, smoothly edged lesion which showed marked contrast-medium uptake with a "salt and pepper" configuration in the region of the right jugular foramen.
  • The diagnosis was hypoglossal paresis due to ipsilateral jugular paraganglioma (Fisch classification C1).
  • Following embolization of the feeding vessels of the paraganglioma, the tumor was completely resected, including the hypoglossal nerve which ran through the tumor.
  • [MeSH-major] Paraganglioma / complications. Paraganglioma / surgery. Speech Disorders / etiology. Speech Disorders / prevention & control. Tongue Diseases / etiology. Tongue Diseases / prevention & control. Vascular Neoplasms / complications. Vascular Neoplasms / surgery
  • [MeSH-minor] Adult. Atrophy / diagnosis. Atrophy / etiology. Atrophy / prevention & control. Female. Humans. Treatment Outcome

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  • [Cites] Head Neck. 2002 Apr;24(4):384-9 [11933180.001]
  • [Cites] HNO. 2004 Jul;52(7):651-60; quiz 661 [15309263.001]
  • [Cites] Curr Opin Otolaryngol Head Neck Surg. 2008 Oct;16(5):420-6 [18797283.001]
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  • [Cites] Laryngorhinootologie. 2006 Sep;85(9):649-56 [16612748.001]
  • (PMID = 19727629.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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33. Ekberg T, Nestor M, Engström M, Nordgren H, Wester K, Carlsson J, Anniko M: Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue. Int J Oncol; 2005 May;26(5):1177-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue.
  • HER2, HER3, and HER4 were evaluated by immunohistochemistry in 19 cases of metastatic squamous cell carcinoma of the oral cavity and base of tongue.
  • In order to further investigate the distribution of HER3, two HER3 expressing cell lines originating from tongue cancer were analysed in vitro, using radiolabelled anti-HER3 antibodies directed to the extracellular domains of the receptor.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Expression Profiling. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis. Receptor, ErbB-3 / biosynthesis. Tongue Neoplasms / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Ligands. Male. Middle Aged. Receptor, ErbB-4. Tumor Cells, Cultured

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  • (PMID = 15809707.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ligands; EC 2.7.10.1 / ERBB4 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-3; EC 2.7.10.1 / Receptor, ErbB-4
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34. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • Immunohistochemical examination revealed that this tumor had neuroendocrine differentiation.
  • It was diagnosed as LCNEC of the tongue base.
  • Basal cells in the normal squamous epithelium around the tumor indicated positivity for neural cell adhesion molecule and N-cadherin.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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35. Siebert FA, Born T, Häring S, Seefeld F, Kovács G: A dosimetric analysis of interstitial intensity modulated implants for pelvic recurrences, base of tongue and orbita tumors with specific references to the ICRU-58. Radiother Oncol; 2006 Jun;79(3):298-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A dosimetric analysis of interstitial intensity modulated implants for pelvic recurrences, base of tongue and orbita tumors with specific references to the ICRU-58.
  • PATIENTS AND METHODS: The evaluation included 76 patient plans: (a) 31 pelvic recurrences, (b) 30 base of tongue tumors, and (c) 15 orbita tumors were analysed retrospectively and the mean central doses (MCD) and relative reference doses were evaluated.
  • CONCLUSIONS: Reduction of the reference dose yields to higher dose inhomogeneities and affects the positive local tumor control.
  • [MeSH-major] Brachytherapy / instrumentation. Brachytherapy / standards. Colorectal Neoplasms / radiotherapy. Orbital Neoplasms / radiotherapy. Pelvic Neoplasms / radiotherapy. Tongue Neoplasms / radiotherapy

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  • (PMID = 16730084.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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41. Li XH, Sun JL, Zhang P, Hu J, Zhang CP, Ji T: [Nanomanipulation of sections of human tongue squamous cell carcinoma by atomic force microscopy]. Zhonghua Yi Xue Za Zhi; 2006 Feb 28;86(8):520-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Nanomanipulation of sections of human tongue squamous cell carcinoma by atomic force microscopy].
  • OBJECTIVE: To investigate the appropriate nanomanipulation of slides of human tongue squamous cell carcinoma tissue and cultured cells by atomic force microscopy (AFM), and develop methods to improve the resolution and contrast of AFM images.
  • METHODS: Human tongue squamous carcinoma cells of the line Tca8113 were cultured.
  • Samples of human tongue squamous carcinoma were collected from 15 cases.
  • CONCLUSION: A series of modified techniques of preparing and treating AFM samples, such as adhering the sections onto mica slide, dissolving of epoxy resin by hydrogen dioxide and removal of paraffin by dimethylbenzene, were developed, thus realizing high resolving power AFM imaging, especially for nuclear membrane, and nucleolus, and providing a base of AFM location, dissection, isolation and obtainment at nanometer scale.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Microscopy, Atomic Force / methods. Nanotechnology / methods. Tongue Neoplasms / pathology
  • [MeSH-minor] Humans. Tumor Cells, Cultured

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  • (PMID = 16681879.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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42. Sugi M, Yanishi M, Shimada O, Kawakita S, Murota T, Shikata N: [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report]. Hinyokika Kiyo; 2008 May;54(5):373-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine differentiation and metastasized to brain stem, intraorbit and base of tongue in prostate cancer during hormonal treatment: a case report].
  • Prostatic neuroendocrine (NE) carcinoma is a rare disease and the NE differentiation in prostate cancer is characterized by poor prognosis, rapidly progressing tumor and an androgen-independent state, for which there is currently no successful therapy.
  • Herein, we report a case of NE differentiatiated prostatic cancer, which metastasized to the base of tongue, intraorbit and brain stem.
  • This is the first Japanese report of prostate cancer metastasis to the brain stem and base of the tongue.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Stem Neoplasms / secondary. Carcinoma, Neuroendocrine / pathology. Cell Differentiation. Orbital Neoplasms / secondary. Prostatic Neoplasms / pathology. Tongue Neoplasms / secondary
  • [MeSH-minor] Androgen Antagonists / therapeutic use. Drug Resistance, Neoplasm. Humans. Male. Middle Aged


43. Gupta R, Gupta K, Gupta R: Polymorphous low-grade adenocarcinoma of the tongue: a case report. J Med Case Rep; 2009;3:9313

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polymorphous low-grade adenocarcinoma of the tongue: a case report.
  • INTRODUCTION: Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions.
  • In rare cases, the mass can also occur in the tongue.
  • We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.
  • CASE PRESENTATION: A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa.
  • Its occurrence in the tongue is rare with very few cases reported in the literature.
  • It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.

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  • [Cites] Mod Pathol. 1990 Jan;3(1):76-82 [2308924.001]
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  • (PMID = 20062742.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803836
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44. Hillyer S, Vicens JC, Levinson H, Bhayani R, Mesea L, Chaudhry R, Fayans E, Fogler R: Alveolar soft-part sarcoma of the tongue in a 17-month-old. Ear Nose Throat J; 2009 Oct;88(10):E4-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the tongue in a 17-month-old.
  • Alveolar soft-part sarcoma (ASPS) is a rare and often fatal tumor.
  • In children, ASPS rarely occurs in the oral cavity, and to the best of our knowledge, only 12 cases of ASPS of the tongue occurring during the first decade of life have been previously reported in the literature.
  • Our patient was a 17-month-old girl whose tumor was located at the base of the tongue.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Staging. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Radionuclide Imaging. Sodium Pertechnetate Tc 99m. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 19826991.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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45. Elakkumanan LB, Chhabra A, Bose S, Sharma K: Granular cell myoblastoma of tongue: a rare cause of unanticipated difficult intubation. Middle East J Anaesthesiol; 2010 Feb;20(4):573-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell myoblastoma of tongue: a rare cause of unanticipated difficult intubation.
  • We report a case of granular cell myoblastoma of the tongue, as a cause of an unanticipated impossible intubation.
  • There was a mass arising from the base of the tongue because of which no recognizable epiglottis or glottic structure could be identified.
  • [MeSH-major] Granular Cell Tumor / pathology. Intubation, Intratracheal / methods. Neoplasms, Muscle Tissue / pathology. Tongue Neoplasms / pathology

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  • (PMID = 20394257.001).
  • [ISSN] 0544-0440
  • [Journal-full-title] Middle East journal of anaesthesiology
  • [ISO-abbreviation] Middle East J Anaesthesiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lebanon
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46. Soderberg C, Perez DS, Ukpo OC, Liang X, O'Reilly AG, Moore EJ, Kademani D, Smith DI: Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas. Cytogenet Genome Res; 2008;121(3-4):201-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential loss of expression of common fragile site genes between oral tongue and oropharyngeal squamous cell carcinomas.
  • The expression of these genes is frequently abrogated in a number of different cancers and several of them have already been shown to function as tumor suppressor genes, both in vitro and in vivo.
  • The first were oral tongue squamous cell carcinomas (SCCs) and the second were base of tongue/tonsillar (oropharyngeal) SCCs.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Chromosome Fragile Sites. Gene Expression Profiling. Oropharyngeal Neoplasms / genetics. Tongue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Primers. Female. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18758160.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA Primers
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47. Bennett BR, Lamba MA, Elson HR: Analysis of peripheral doses for base of tongue treatment by linear accelerator and helical TomoTherapy IMRT. J Appl Clin Med Phys; 2010 Jun 21;11(3):3136

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of peripheral doses for base of tongue treatment by linear accelerator and helical TomoTherapy IMRT.
  • Following the RTOG IMRT Protocol 0522, treatment of the primary tumor and involved nodes (PTV70) and subclinical disease sites (PTV56) was planned utilizing IMRT to 70Gy and 56 Gy.

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  • (PMID = 20717081.001).
  • [ISSN] 1526-9914
  • [Journal-full-title] Journal of applied clinical medical physics
  • [ISO-abbreviation] J Appl Clin Med Phys
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Diapera MJ, Lozon CL, Thompson LD: Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases. Am J Otolaryngol; 2009 Mar-Apr;30(2):101-5
MedlinePlus Health Information. consumer health - Tongue Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases.
  • BACKGROUND: Extra-urogenital tract malacoplakia is uncommon, with tongue malacoplakia being exceptionally rare.
  • MATERIALS AND METHODS: Five case reports of tongue malacoplakia were compiled from the literature (MedLine 1960-2008) and integrated with this case report.
  • The base of the tongue was the most frequent site, although midline tongue and half of the tongue were also affected.
  • These findings support a diagnosis of malacoplakia.
  • The differential diagnosis includes granular cell tumor, poorly differentiated carcinoma, and Langerhans histiocytosis.
  • CONCLUSIONS: Tongue malacoplakia is rare, often presenting as a mass lesion.
  • Histologic recognition of this abnormal phagocytic disorder will prevent potentially disfiguring surgery.
  • [MeSH-major] Malacoplakia / pathology. Tongue Diseases / pathology

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  • (PMID = 19239951.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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49. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Pardo Romero G, Trinidad Ramos G, Blasco Huelva A: [Adenoid cystic carcinoma of tongue. Report of a case and literature review]. An Otorrinolaringol Ibero Am; 2006;33(5):449-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of tongue. Report of a case and literature review].
  • [Transliterated title] Carcinoma adenoide quístico de lengua. A propósito de un caso y revisión de la literatura.
  • We report the clinical case of an adenoid cystic carcinoma on the base of the tongue, a rare malignant tumor of slow-growing but aggressive with a propepnsity for perineural invasion.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Humans. Laryngectomy. Magnetic Resonance Imaging. Male. Middle Aged. Tongue / pathology. Tongue / surgery. Treatment Outcome

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  • (PMID = 17091857.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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50. Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X: Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer; 2010 Aug 1;127(3):505-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
  • Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC).

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  • (PMID = 20232393.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NIDCR NIH HHS / DE / DE014847-05S1; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / R03 CA135992-01A1; United States / NCI NIH HHS / CA / CA135992-01A1; United States / NIDCR NIH HHS / DE / K22 DE014847; United States / NIDCR NIH HHS / DE / K22 DE014847-05S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RHOC protein, human; 0 / RNA, Messenger; 0 / ROCK2 protein, human; EC 2.7.11.1 / rho-Associated Kinases; EC 3.6.5.2 / rho GTP-Binding Proteins
  • [Other-IDs] NLM/ NIHMS203801; NLM/ PMC2885137
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51. Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X: MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochem J; 2010 Nov 15;432(1):199-205
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  • [Title] MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells.
  • miR-7 (microRNA-7) has been characterized as a tumour suppressor in several human cancers.
  • However, the mechanism(s) by which miR-7 suppresses tumorigenesis in TSCC (tongue squamous cell carcinoma) is unknown.

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  • (PMID = 20819078.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA135992-02; United States / NCI NIH HHS / CA / R03CA135992; United States / NCI NIH HHS / CA / R01 CA139596-03; United States / NIDCR NIH HHS / DE / K22DE014847; United States / NCI NIH HHS / CA / R01CA139596; United States / NCI NIH HHS / CA / R01 CA139596; United States / NCI NIH HHS / CA / R03 CA135992; United States / NIDCR NIH HHS / DE / K22 DE014847-05; United States / NCI NIH HHS / CA / CA139596-03; United States / NIDCR NIH HHS / DE / K22 DE014847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / MIRN7 microRNA, human; 0 / MicroRNAs; 0 / RNA, Messenger; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.13.12.- / Luciferases; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Other-IDs] NLM/ NIHMS302690; NLM/ PMC3130335
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52. Ukpo OC, Pritchett CV, Lewis JE, Weaver AL, Smith DI, Moore EJ: Human papillomavirus-associated oropharyngeal squamous cell carcinomas: primary tumor burden and survival in surgical patients. Ann Otol Rhinol Laryngol; 2009 May;118(5):368-73

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  • [Title] Human papillomavirus-associated oropharyngeal squamous cell carcinomas: primary tumor burden and survival in surgical patients.
  • OBJECTIVES: We sought to determine whether the primary tumor burden in oropharyngeal squamous cell carcinoma is lower in tumors positive for human papillomavirus (HPV) or in tumors with a smoking- or alcohol-related cause.
  • METHODS: We retrospectively reviewed medical records of patients at our institution who had squamous cell carcinoma of the palatine tonsils, base of tongue, soft palate, or pharynx from 1995 through 2006.
  • Primary tumor size was not significantly different between HPV-positive and HPV-negative tumors (median, 2.5 versus 2.0 cm; p = 0.43).
  • CONCLUSIONS: Primary tumor burden was not associated with HPV status.
  • [MeSH-major] Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / virology. Papillomavirus Infections / complications. Tongue Neoplasms / pathology. Tongue Neoplasms / virology
  • [MeSH-minor] Aged. Alcohol Drinking / epidemiology. Carcinoma, Squamous Cell. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Factors. Smoking / epidemiology. Tonsillar Neoplasms / surgery. Tonsillar Neoplasms / virology. Tumor Burden

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  • (PMID = 19548387.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Zhang WC, Zhang L, Wang XD, Wu YS: [Clinical and pathological analysis of malignant carotid body tumor]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;43(8):591-5
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  • [Title] [Clinical and pathological analysis of malignant carotid body tumor].
  • OBJECTIVE: To summarize the clinical, pathological and prognosis character of malignant carotid body tumor and explore its methods of diagnosis and treatment.
  • METHODS: The data of clinic, pathology, treatment and follow-up of nine patients with malignant carotid body tumor in Tianjin Cancer Hospital from February 1982 to June 2006 were analyzed retrospectively.
  • Seven cases were diagnosed as carotid body tumor.
  • All the patients were performed wide excision of tumor and surrounding tissue.
  • Before operation, one case had atrophy of left side of tongue and fixed left vocal card; two cases had Horner syndrome.
  • Pathologic diagnosis included nine malignant carotid body tumors, two with capsule, seven without capsule, one cervical and one lung metastasis.
  • CONCLUSIONS: Malignant carotid body tumor is rare in clinic, and often invade the carotid and cranial nerve, the diagnosis of malignant tumor should base on occurring extensive invasion of adjacent organs and metastasis; Wide surgical excision should be selected early, radiotherapy is effective, the effect of chemotherapy is uncertainty.
  • [MeSH-major] Carotid Body Tumor / pathology. Carotid Body Tumor / surgery. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery

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  • (PMID = 18959263.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Mühlmeier G, Reske SN, Blumstein NM, Völker HU, Maier H: [The importance of PET in searching the primary tumor site in CUP patients -- a case report]. Laryngorhinootologie; 2005 Jul;84(7):516-9

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  • [Title] [The importance of PET in searching the primary tumor site in CUP patients -- a case report].
  • Clinical examination, MRT scans and panendoscopy did not detect the primary tumour site.
  • The positron emission tomography localized an uptake of FDG in the left sided base of the tongue.
  • In the left tongue base an induration was palpable which was resected with security distance.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / secondary. Lymphatic Metastasis / radionuclide imaging. Neoplasms, Unknown Primary / radionuclide imaging. Positron-Emission Tomography. Tongue Neoplasms / radionuclide imaging
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Sensitivity and Specificity. Tongue / pathology. Tongue / radionuclide imaging

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  • (PMID = 16010634.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, Hartig GK: Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope; 2008 Aug;118(8):1377-82
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  • [Title] Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy.
  • OBJECTIVES/HYPOTHESIS: Tumor volume has been demonstrated to play a prognostic role in many head and neck cancers.
  • The purpose of this study was to conduct an institutional review analyzing the correlation between tumor volume and locoregional control of oropharyngeal squamous cell cancer treated with primary radiotherapy.
  • METHODS: Seventy-nine patients from 1991 to 2005 with primary T1 to T4 oropharyngeal squamous cell carcinoma (base of tongue, n = 31; soft palate, n = 1; tonsils, n = 47) were treated with primary radiotherapy.
  • Tumor volumes were measured from pretreatment computerized tomography scans by two observers.
  • Three-dimensional tumor volumes were calculated using a computer digitizer for each computed tomography slice showing the primary lesion.
  • Survival analysis, using the methods of Kaplan and Meier, was performed to assess whether tumor volume, Tumor, Node, Metastasis classification, tumor stage, or location were associated with locoregional failure.
  • RESULTS: Tumor volume did not significantly correlate with locoregional failure (observer 1, P = .6244; observer 2, P = .5612).
  • Nodal status, tumor stage, and location did not significantly correlate with locoregional failure rate.
  • CONCLUSIONS: Tumor volume does not appear to play a significant role in predicting locoregional recurrence for patients with primary squamous cell cancer of the oropharynx treated with primary radiotherapy.
  • [MeSH-minor] Female. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Observer Variation. Prognosis. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18418275.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Dong MJ, Zhao K, Lin XT, Zhao J, Ruan LX, Liu ZF: Role of fluorodeoxyglucose-PET versus fluorodeoxyglucose-PET/computed tomography in detection of unknown primary tumor: a meta-analysis of the literature. Nucl Med Commun; 2008 Sep;29(9):791-802
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  • [Title] Role of fluorodeoxyglucose-PET versus fluorodeoxyglucose-PET/computed tomography in detection of unknown primary tumor: a meta-analysis of the literature.
  • These studies evaluated the role of FDG-PET and FDG-PET/CT in the detection of unknown primary tumors after physical examination and conventional workup failed to detect a primary tumor.
  • Systematic methods were used to identify, select, and evaluate the methodological quality of the studies as well as to summarize the overall findings of sensitivity, specificity, and detection capacity of the primary tumor.
  • Tumors from the base of the tongue accounted for 20.7% (six of 29) of all false-positive FDG-PET scans, corresponding to a false-positive rate of 28.6% (six of 29), much higher than tumors from the others.
  • FDG-PET exhibited a lower sensitivity with respect to the tumors at the base of the tongue and tonsils, which was 68.2 and 76.7%, respectively.
  • FDG-PET exhibited lower sensitivity with respect to the tumors at the base of the tongue and the tonsils.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacology. Neoplasms / diagnosis. Positron-Emission Tomography / methods. Radiopharmaceuticals / pharmacology. Tomography, X-Ray Computed / methods

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  • (PMID = 18677207.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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57. Simon C, Goepfert H, Rosenthal DI, Roberts D, El-Naggar A, Old M, Diaz EM Jr, Myers JN: Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival. Eur Arch Otorhinolaryngol; 2006 Apr;263(4):313-8
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  • [Title] Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival.
  • It is reported that nearly 50% of the neck dissection specimens contain residual viable tumor cells that may indicate partial radiation failure and as a consequence poor survival.
  • In order to address the significance of this finding, we conducted a nonrandomized retrospective study, including 35 patients who underwent definitive radiation therapy followed by either a radical or modified radical (RND/MRND) or a selective neck dissection (SND) for clinically persistent neck disease 6 weeks after completing therapy for stage III/IV SCC of the oropharynx (base of the tongue =15, tonsil =12, soft palate =7 and pharyngeal wall =1).
  • All neck dissection specimens were reviewed according to histological criteria indicating viable residual tumor.
  • The presence of malignant tumor cells in residual disease in the neck correlated with poor disease-specific and overall survival (P =0.03 and P =0.01, respectively).
  • [MeSH-minor] Adult. Aged. Cell Survival. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm, Residual. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16328403.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Cakli H, Altin F, Ak I, Gürbüz MK, Ozüdoğru E: [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report]. Kulak Burun Bogaz Ihtis Derg; 2005;14(1-2):39-43
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  • [Title] [Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report].
  • Investigation with positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose suggested the base of the tongue as the primary site, which was then confirmed by an endoscopic biopsy from the tongue.
  • It should be borne in mind that positron emission tomography may be helpful in the diagnosis of unknown primary tumors with cervical metastasis.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Neoplasms, Unknown Primary / diagnosis. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / radiography. Neoplasms, Unknown Primary / surgery. Positron-Emission Tomography

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  • (PMID = 16227723.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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59. Sundaram K, Schwartz J, Har-El G, Lucente F: Carcinoma of the oropharynx: factors affecting outcome. Laryngoscope; 2005 Sep;115(9):1536-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES/HYPOTHESIS: To assess the value of both patient- and tumor-related factors of oropharyngeal squamous cell carcinoma in predicting patient outcome, with respect to the three primary subsites of the disease.
  • 1) base of tongue, 2) tonsil and pillars, and 3) uvula, soft palate, and posterior pharyngeal wall.
  • Tumor-related factors included American Joint Committee on Cancer stage, T stage, N stage, and grade.
  • RESULTS: Tumor-related factors such as American Joint Committee on Cancer stage (P = .016) and T stage (P = .008) had a significant impact on treatment response.
  • Base-of-tongue lesions responded significantly worse to treatment than did tonsil and pillar or uvula, soft palate, and posterior pharyngeal wall lesions (P = .014).
  • The disease-free survival for base-of-tongue cancer was significantly worse than for tonsil and pillar or for uvula, soft palate, and posterior pharyngeal wall cancer (P = .010).
  • Important tumor-related factors were the American Joint Committee on Cancer stage and the T stage.
  • Among the oropharyngeal subsites, squamous cell carcinoma of the base of tongue was associated with the worst outcome.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palate, Soft. Sex Factors. Tongue. Tonsillar Neoplasms. Treatment Outcome. Uvula

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  • (PMID = 16148691.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Seshadri M, Merzianu M, Tang H, Rigual NR, Sullivan M, Loree TR, Popat SR, Repasky EA, Hylander BL: Establishment and characterization of patient tumor-derived head and neck squamous cell carcinoma xenografts. Cancer Biol Ther; 2009 Dec;8(23):2275-83
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  • [Title] Establishment and characterization of patient tumor-derived head and neck squamous cell carcinoma xenografts.
  • The overall purpose of this study was to establish human head and neck squamous cell carcinoma (HNSCC) xenografts in mice by transplantation of surgical tumor tissue and to characterize the growth, histologic and vascular properties of these xenografts.
  • Histologic features of primary HNSCC specimens, initial and established xenografts were compared for tumors established from three different head and neck subsites, namely, oral cavity, larynx and base of tongue (one tumor per site).
  • Growth rates of xenografts were compared along with magnetic resonance imaging (MRI) measures of tumor vascularity and correlative CD31-immunostaining.
  • Initial and established xenografts from all three sites demonstrated a squamous phenotype similar to the original patient tumor histology.
  • Established xenografts of oral cavity and larynx exhibited increased keratinization (H&E) compared to initial xenografts and the primary tumor.
  • No differences in tumor growth rates were observed between established xenografts from the different subsites.
  • Xenografts established from SCC of the larynx exhibited increased microvessel density and lumen area (CD31 staining) along with enhanced permeability to the MR contrast agent compared to oral cavity and base of tongue tumors.
  • Our results show that the combination of non-invasive imaging along with histologic evaluation of patient tumor xenografts offers a valuable platform for preclinical investigations in head and neck cancer.
  • However, it is important to recognize the influence of tumor-host interactions on the histologic phenotype of transplanted tumors.

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  • [CommentIn] Cancer Biol Ther. 2009 Dec;8(23):2284-5 [20009578.001]
  • (PMID = 19829072.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016056; None / None / / P30 CA016056-33; United States / NCI NIH HHS / CA / P30 CA016056-33; United States / NCI NIH HHS / CA / P30CA16056
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31
  • [Other-IDs] NLM/ NIHMS212969; NLM/ PMC2906774
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61. Kojima M, Sugihara S, Iijima M, Ono T, Yoshizumi T, Masawa N: Marginal zone B-cell lymphoma of minor salivary gland representing tumor-forming amyloidosis of the oral cavity. A case report. J Oral Pathol Med; 2006 May;35(5):314-6
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  • [Title] Marginal zone B-cell lymphoma of minor salivary gland representing tumor-forming amyloidosis of the oral cavity. A case report.
  • We report here a case of mucosa-associated lymphoid tissue (MALT)-type lymphoma arising from the minor salivary gland of the oral cavity exhibiting tumor-forming amyloidosis.
  • Despite multiple and multifocal recurrences including the lip, soft palate, tongue, oral base and vocal code and soft palate, the tumor remained localized in the upper aerodigestive tract, and the patient did not develop multiple myeloma during the course of disease.
  • The present case indicates that primary minor salivary gland MALT-type lymphoma appears to be the cause of tumor-forming amyloidosis of the upper aerodigestive tract including the larynx.

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  • (PMID = 16630297.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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62. Nakamura T, Kodaira T, Tachibana H, Tomita N, Yokouchi J, Fuwa N: Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy. Oral Oncol; 2009 Sep;45(9):830-4
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  • Nine patients who had a tumor in the base of the tongue were also treated with arterial infusion chemotherapy.
  • The 5-year local control rate for each subsite was: anterior wall, 90%; lateral wall, 80%; posterior wall, 67%; and superior wall, 64%.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy / methods. Disease-Free Survival. Feasibility Studies. Female. Fluorouracil / administration & dosage. Humans. Japan. Male. Middle Aged. Neoplasm Recurrence, Local. Organoplatinum Compounds / administration & dosage. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 19457713.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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63. El-Mofty SK, Patil S: Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):339-45
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  • A total of 235 carcinomas were reviewed; 141 of the tonsils and 94 in the base of tongue.
  • Ninety (36%) of the tonsillar and 30 (32%) of the base of tongue carcinomas were nonkeratinizing (NKCa) with basal cell features; the rest were classical keratinizing squamous cell carcinomas (KSCC).
  • It is concluded that NKCa of the tonsils and base of tongue is a distinct subtype of squamous cell carcinoma of the head and neck with high prevalence of HPV DNA and a characteristic immunophenotype.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Oropharyngeal Neoplasms / virology. Papillomavirus Infections / pathology. Tongue Neoplasms / virology
  • [MeSH-minor] Case-Control Studies. DNA, Viral / analysis. Female. Histocytochemistry. Humans. Immunophenotyping. Keratins / analysis. Ki-67 Antigen / analysis. Male. Middle Aged. Palatine Tonsil / pathology. Papillomaviridae / genetics. Phenotype. Polymerase Chain Reaction. Sequence Analysis, DNA. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16504868.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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64. El-Mofty SK: Human papillomavirus (HPV) related carcinomas of the upper aerodigestive tract. Head Neck Pathol; 2007 Dec;1(2):181-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Epidemiologic, clinical, morphologic and molecular evidence show that high risk HPV, particularly type 16, is a prerequisite for some carcinomas of the upper aerodigestive tract (UADT), particularly tonsil and base of tongue.
  • They usually present as a small or occult primary tumor with advanced neck disease.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Palatine Tonsil / pathology. Papillomavirus Infections / pathology. Tongue Neoplasms / pathology. Tonsillar Neoplasms / pathology. Tumor Virus Infections / pathology
  • [MeSH-minor] Alphapapillomavirus / genetics. Alphapapillomavirus / immunology. Alphapapillomavirus / isolation & purification. Biomarkers, Tumor / metabolism. DNA, Viral / analysis. Female. Humans. Male. Viral Vaccines

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  • (PMID = 20614273.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Viral Vaccines
  • [Other-IDs] NLM/ PMC2807527
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65. Alharbi FA, Lenarz T, Stoever T: A case of unilateral hypoglossus nerve palsy associated with chordoma in the region of clivus. Eur Arch Otorhinolaryngol; 2009 Dec;266(12):2001-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A computed tomography (CT) scan of the skull base showed bone destruction at the anterior part of the foramen magnum and CT scan of the neck reveals asymmetrical area at the base of the tongue.
  • Magnetic resonance imaging showed a mass at the skull base in the region of the clivus with bone destruction in the middle and right side of the clivus.
  • The tumor was biopsied through transnasal biopsy from the region of the clivus using a navigation system and microscopical surgical technique.
  • A carbon ion radiotherapy is an effective treatment for chordomas of the skull base with minimal side effects.
  • [MeSH-major] Chondroma / complications. Cranial Fossa, Posterior. Hypoglossal Nerve Diseases / etiology. Skull Base Neoplasms / complications
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures / methods. Tomography, X-Ray Computed

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  • (PMID = 19590882.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Enoz M, Suoglu Y, Ilhan R: Lingual schwannoma. J Cancer Res Ther; 2006 Apr-Jun;2(2):76-8
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  • Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath.
  • Intraoral schwannoma accounts for 1% of head and neck region and are commonly seen at the base region of tongue.
  • Most of the few such reports in the literature, have described schwannomas that occurred in the tongue.
  • In this article, we report a rare case of lingual schwannoma involving the anterior of tongue, in a young individual, in whom the lesion was completely excised via an intra oral approach.
  • [MeSH-major] Neurilemmoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17998681.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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67. Lai G, Nemolato S, Lecca S, Parodo G, Medda C, Faa G: The role of immunohistochemistry in the diagnosis of hyalinizing clear cell carcinoma of the minor salivary gland: a case report. Eur J Histochem; 2008 Oct-Dec;52(4):251-4
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in the diagnosis of hyalinizing clear cell carcinoma of the minor salivary gland: a case report.
  • A 52- year-old woman presented with a growing mass at the base of the tongue.
  • The patient underwent complete resection of the tumour.
  • Tumour cells were immunoreactive for Cytokeratins 5, 6, 7, 8, 14, 17 and 18.
  • These findings confirmed the diagnosis of HCCC of minor salivary glands of the oral cavity.
  • The clinical presentation, the immunohistochemical pattern and the role of cytokeratins in the differential diagnosis of HCCC are discussed with a review of the literature.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Immunohistochemistry / methods. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Female. Humans. Hyalin / metabolism. Keratins / analysis. Melanoma / diagnosis. Melanoma / secondary. Middle Aged. Myoepithelioma / diagnosis

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  • (PMID = 19109100.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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68. Strek P, Hydzik-Sobocińtska K, Składzień J, Modrzejewski M, Zagólski O, Blaschke J, Najdzionek D, Kurzyński M, Muszyński P, Gawlik J, Dutsch-Wicherek M: [Self-assessment of the effect of dysphagia on the quality of life in patients after partial laryngectomy for cancer initially located in the supraglottic area]. Pol Merkur Lekarski; 2005 Sep;19(111):362-4
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  • The subjective evaluation by the patient of dysphagia is directly related to the size of the tumor and the extent of the partial laryngectomy treatment.
  • Patients, whose tumor was located in supraglottic-glottic area, had subtotal laryngectomy m. Miodoński.
  • Reconstruction of the base of a tongue by a graft of angiopedunculated submandibular gland diminished the difficulties in swallowing.

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  • (PMID = 16358871.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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69. Liu W, Gnepp DR, de Vries E, Bibawy H, Solomon M, Gloster ES: Mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum: a case report. Head Neck Pathol; 2009 Mar;3(1):59-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialadenoma papilliferum is a rare tumor, primarily of minor salivary gland origin, first described by Abrams and Finck (Cancer 24:1057-63, 1969).
  • The tumor is considered benign although rare recurrent cases have been reported.
  • We report a high grade mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum, at the base of the tongue, an unusual location for minor salivary gland neoplasms.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 20596992.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807533
  • [Keywords] NOTNLM ; Mucoepidermoid carcinoma / Salivary gland / Sialadenoma papilliferum
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70. Guclu E, Tokmak A, Oghan F, Ozturk O, Egeli E: Hemimacroglossia caused by isolated plexiform neurofibroma: a case report. Laryngoscope; 2006 Jan;116(1):151-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The present case is a diffuse isolated plexiform neurofibroma of the tongue that was not associated with neurofibromatosis that we treated with intraoral surgery.
  • METHODS: We present a 5-year-old girl with isolated plexiform neurofibroma of the tongue with infiltration of the tongue base and review treatment approaches for this very rare tumor.
  • CONCLUSIONS: Isolated plexiform neurofibroma of the tongue is very rare.
  • It causes a massive macroglossia that is progressive with advance of years and disturbs the patient's speech, occlusion, and tongue movements.
  • Involvement of the tongue may be associated with infiltration into the deep structures of the neck by the tumor, thereby presenting considerable operative difficulties.
  • [MeSH-major] Macroglossia / etiology. Macroglossia / pathology. Neurofibroma, Plexiform / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 16481830.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Iyer NG, Kim L, Nixon IJ, Palmer F, Kraus D, Shaha AR, Shah JP, Patel SG, Ganly I: Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx. Arch Otolaryngol Head Neck Surg; 2010 Dec;136(12):1240-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: the most common histologic types were mucoepidermoid carcinoma in 26 patients (39%), adenoid cystic carcinoma in 16 (24%), adenocarcinoma in 16 (24%), and malignant mixed tumor in 7 (10%).
  • The tumors were located in the base of the tongue in 41 patients (61%), soft palate in 20 (30%), and tonsil in 6 (9%).
  • Tumor recurred in 20 patients (34%); 12 of these patients had locoregional failure and 15 developed distant metastases.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasm Recurrence, Local / epidemiology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Salivary Glands, Minor. Survival Rate / trends. Time Factors. United States / epidemiology. Young Adult

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  • (PMID = 21173374.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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72. Deleyiannis FW, Rogers C, Lee E, Russavage J, Gastman B, Dunklebarger J, Lai S, Ferris R, Myers EN, Johnson J: Reconstruction of the lateral mandibulectomy defect: management based on prognosis and location and volume of soft tissue resection. Laryngoscope; 2006 Nov;116(11):2071-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Patient and tumor variables were extracted from the medical records.
  • RESULTS: Age greater than 70 years (P = .03), moderate or severe comorbidity (P = .01), and tumor involvement of the base of tongue (P = .03) were significantly associated with decreased use of a free flap and with decreased 3-year survival rates.

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  • (PMID = 17075408.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Sanchez Morillo J, Solaz Roldan C, Aznar MR, Mompó Romero L, Barber Ballester G, Santamaría Vázquez J: [Use of a rigid laryngoscope and a flexible nasal fiberoptic scope to assess the difficult airway: description of 3 cases]. Rev Esp Anestesiol Reanim; 2010 Feb;57(2):91-4
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  • [Transliterated title] Utilización del laringoscopio rígido y el nasofibroscopio flexible en la valoración de la vía aérea difícil: descripción de 3 casos.
  • In the first case, the epiglottis was absent, as it had been removed with a surrounding tumor; in the second and third cases, an epiglottic deformity and hypertrophy of the base of the tongue were found.
  • [MeSH-major] Airway Obstruction / diagnosis. Fiber Optic Technology / instrumentation. Laryngoscopes. Otolaryngology / instrumentation. Preoperative Care / methods
  • [MeSH-minor] Aged. Biopsy. Epiglottis / pathology. Epiglottis / surgery. Female. Humans. Hypertrophy. Intubation, Intratracheal. Male. Middle Aged. Overweight / complications. Pharyngeal Neoplasms / surgery. Postoperative Complications / pathology. Pyriform Sinus / pathology. Spinal Cord Compression / surgery. Tongue / pathology. Tongue / surgery. Vitrectomy

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  • (PMID = 20337000.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
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74. Fidan V, Sütbeyaz Y: Lingual cystic lymphangioma in an elderly patient. Kulak Burun Bogaz Ihtis Derg; 2008 Jul-Aug;18(4):260-2
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  • A 67-year-old man presented with a multilobulated, soft lesion at the tip of the tongue, causing articulation problem.
  • Oral examination showed a multilobular mass with a large base, 15 x 15 x 10 mm in size.
  • Magnetic resonance imaging showed a multilocular cystic tumor.
  • After surgery, tongue movement and sensation were normal.
  • Histopathologic diagnosis was cystic lymphangioma.
  • [MeSH-major] Lymphangioma, Cystic / diagnosis. Tongue / surgery. Tongue Neoplasms / diagnosis

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  • (PMID = 19052498.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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75. Pabiszczak M, Wierzbicka M, Szyfter W: [Localisation and direction of spread in oral and oropharyngeal cancer in the material of Head and Neck Oncological Surgery Department, University of Medical Sciences in Poznań]. Otolaryngol Pol; 2005;59(2):201-7
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  • The directions of tumor spread are determined by the anatomy of the affected organ.
  • The vessel, nerve anatomy and presence of structures, that may potentially constitute a barrier for spread out of the tumor are of crucial importance.
  • The examination was conducted on the base of retrospective analysis of ambulatory charts and the hospital files.
  • The primary localization included in the palatine tonsil (82 patients), trunk of the tongue (48 patients) and floor of the mouth (20 patients) were predominated.
  • The spread directions included: floor of the mouth (36) soft palate (35), base of tongue (33), hypopharynx (20) and trunk of tongue (16).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Poland. Retrospective Studies

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  • (PMID = 16095088.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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76. Ben-Izhak O, Kablan F, Laster Z, Nagler RM: Oropharyngeal cancer pathogenesis: ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert--first report. Oral Oncol; 2005 Sep;41(8):851-60
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  • The current study was carried out to examine the clinical characteristics and survival-probability rates of 51 patients treated for oral (tongue) cancer and to correlate it with various tumor markers.
  • The 5-year survival-probability correlated with staging, grading and base of tongue location.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Tongue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. S-Phase Kinase-Associated Proteins / metabolism. Survival Analysis. Tumor Suppressor Protein p53 / metabolism. Ubiquitin / metabolism

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  • (PMID = 16043384.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S-Phase Kinase-Associated Proteins; 0 / Tumor Suppressor Protein p53; 0 / Ubiquitin; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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77. Papacharalampous GX, Korres S, Tzagaroulakis M, Segas I, Ferekidis E: Paraganglioma of the larynx: a case report. Med Sci Monit; 2007 Dec;13(12):CS145-8

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  • The subglottic area of the larynx was normal as were the base of the tongue and pharynx.
  • The tumor was entirely removed along with the left aryepiglottic fold with respect to the surrounding tissues.
  • The differential diagnosis of laryngeal paraganglioma includes typical carcinoid, atypical carcinoid, small-cell neuroendocrine carcinoma, malignant melanoma, and medullary carcinoma of the thyroid gland.

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  • (PMID = 18049441.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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78. Miller FR, Karnad AB, Eng T, Hussey DH, Stan McGuff H, Otto RA: Management of the unknown primary carcinoma: long-term follow-up on a negative PET scan and negative panendoscopy. Head Neck; 2008 Jan;30(1):28-34
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  • In an attempt to identify the occult primary tumor the evaluation of this patient population has included a complete head and neck examination, flexible fiberoptic endoscopy, and imaging with CT/MRI.
  • METHODS: A cohort of 31 patients with fine-needle aspiration biopsy-confirmed squamous cell carcinoma were prospectively entered into a diagnostic protocol to identify the occult primary tumor.
  • If the initial diagnostic evaluation failed to identify a primary tumor, the patients then underwent whole body PET imaging followed by staging endoscopy with biopsy of the at-risk occult tumor sites.
  • The outcome measures included the accuracy of the PET to predict the presence of occult tumor at staging endoscopy and the accuracy of the negative PET and negative panendoscopy in predicting the subsequent development of a primary tumor in the upper aerodigestive tract during follow-up.
  • Five occult primary tumors (2 base of tongue and 3 palatine tonsil) were detected during panendoscopy despite a negative PET.
  • Seventeen patients (N1, n = 7; N2a, n = 4; N2b, n = 2; N3, n = 4) had no primary tumor detected and were treated as an unknown primary carcinoma with primary neck dissection +/- radiation therapy +/- chemotherapy.
  • In addition, only 1 patient (5.8%) developed a primary tumor of the upper aerodigestive tract with a mean follow-up of 31.1 months (range, 21-60 months).
  • CONCLUSION: A negative PET study in patients with an occult primary head and neck carcinoma does not preclude the need for panendoscopy with biopsy to detect the occult primary tumor.
  • The risk of subsequent primary tumor appears to be low in the patients with a negative PET and a negative panendoscopy (<6%).
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Endoscopy. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary / diagnosis. Positron-Emission Tomography

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  • [Copyright] Copyright (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17657782.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope; 2006 Jul;116(7):1148-52
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  • All patients had curative surgery as their initial treatment for the primary tumor and neck.
  • The incidence rate of level IV metastasis in patients with ipsilateral nodal metastasis was significantly higher in base of tongue cancer (86% [6 of 7]) compared with tonsillar cancer (34% [20 of 59]) (P=.013).
  • CONCLUSION: These results suggest that elective N0 neck treatment in patients with oropharyngeal SCC, especially base of tongue cancer, should include neck levels II, III, and IV instead of levels I, II, and III.
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Neck Dissection. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 16826050.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Dabaja B, Salehpour MR, Rosen I, Tung S, Morrison WH, Ang KK, Garden AS: Intensity-modulated radiation therapy (IMRT) of cancers of the head and neck: comparison of split-field and whole-field techniques. Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1000-5
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  • IMRT is delivered to the primary tumor and upper neck alone, while the lower neck is treated with a matching anterior beam.
  • WF-IMRT has an advantage if uncertainty at the match line is a concern, whereas HB-IMRT, particularly in cases not involving the base of tongue, can achieve much lower doses to the larynx.

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  • (PMID = 15978743.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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81. Kennedy TL, Riefkohl WL: Lingual thyroid carcinoma with nodal metastasis. Laryngoscope; 2007 Nov;117(11):1969-73
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  • Further workup revealed the patient's only thyroid tissue was located at the tongue base and was the site of the primary tumor.
  • Review of the computed tomography scan of the neck revealed a tongue base mass, absence of an othotopic thyroid gland and bilateral cervical lymphandenopathy.
  • Bilateral selective neck dissections with removal of the tongue base lesion confirmed the diagnosis of lingual thyroid carcinoma with multiple left cervical nodal metastases.
  • Surgical approaches to the tongue base need to be considered based on the size of the lingual primary tumor and the need to address lymph node metastases gland.
  • [MeSH-major] Carcinoma, Papillary / surgery. Lymph Nodes / pathology. Thyroid Neoplasms / surgery. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis

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  • (PMID = 17828053.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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82. Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Gaziano J, Stachowiak L, Newman L, MacCracken E, Santa D, Mittal B: Swallowing disorders in the first year after radiation and chemoradiation. Head Neck; 2008 Feb;30(2):148-58
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  • RESULTS: At baseline, patients had some swallow disorders, probably related to presence of their tumor.
  • At 3 months posttreatment, frequency of reduced tongue base retraction, slow or delayed laryngeal vestibule closure, and reduced laryngeal elevation increased from baseline.

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  • (PMID = 17786992.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE011921-05S2; United States / NCI NIH HHS / CA / P01 CA40007; United States / NCI NIH HHS / CA / P01 CA040007-15; United States / NCI NIH HHS / CA / CA040007-15; United States / NCI NIH HHS / CA / P50DE/CA11921; United States / NCI NIH HHS / CA / P01 CA040007; United States / NIDCR NIH HHS / DE / P50 DE011921-05S2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
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83. Schwartz DL, Hutcheson K, Barringer D, Tucker SL, Kies M, Holsinger FC, Ang KK, Morrison WH, Rosenthal DI, Garden AS, Dong L, Lewin JS: Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Dec 1;78(5):1356-65
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  • Twenty-one (68%) cases were base of tongue and 10 (32%) were tonsil.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20646872.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R21 CA132281; United States / NCI NIH HHS / CA / CA132281
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS575664; NLM/ PMC4034521
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84. Kutter J, Ozsahin M, Monnier P, Stupp R: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):1-7
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  • The primary tumor involved the hypopharynx (n=7), base of the tongue (n=10), nasopharynx (n=2) or upper esophagus (n=1) or its location was unknown (n=3).
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / drug therapy. Nasopharyngeal Neoplasms / radiotherapy. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Amifostine / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage

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  • (PMID = 15004704.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] M487QF2F4V / Amifostine; Q20Q21Q62J / Cisplatin
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85. Eun YG, Kim MG, Kwon KH, Shin SY, Cho JS, Kim SW: Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea. Acta Otolaryngol; 2010 Dec;130(12):1394-8
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  • METHODS: Fifty-one patients with OSA underwent uvulopalatopharyngoplasty and radiofrequency tongue base reduction.
  • Adiponectin, leptin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were measured with a LINCOplex Human Immunoassay at baseline and 4 weeks after surgical treatment.
  • [MeSH-minor] Adiponectin / blood. Adult. Aged. Electrosurgery. Female. Humans. Interleukin-6 / blood. Leptin / blood. Male. Middle Aged. Palate, Soft / surgery. Patient Satisfaction. Pharynx / surgery. Polysomnography. Reference Values. Tongue / surgery. Tumor Necrosis Factor-alpha / blood. Uvula / surgery

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  • (PMID = 20632906.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adipokines; 0 / Adiponectin; 0 / Cytokines; 0 / Inflammation Mediators; 0 / Interleukin-6; 0 / Leptin; 0 / Tumor Necrosis Factor-alpha
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86. Fuwa N, Kodaira T, Furutani K, Tachibana H, Nakamura T: A new method of selective intra-arterial infusion therapy via the superficial temporal artery for head and neck cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):783-9
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  • Primary tumor sites included the tongue in 73 patients, base of the tongue in 6 patients, floor of mouth in 4 patients, buccal mucosa in 4 patients, and other sites in 5 patients.
  • CONCLUSION: This selective intra-arterial method will be an important modality for advanced tongue cancer.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carboplatin / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Radiography, Interventional / methods. Tongue Neoplasms / drug therapy

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  • (PMID = 18206406.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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87. Knipe TA, Chandra RK, Bugg MF: Sclerosing rhabdomyosarcoma: a rare variant with predilection for the head and neck. Laryngoscope; 2005 Jan;115(1):48-50

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  • METHODS: The authors have reported the case of a 66-year-old woman with a 35-year history of heavy cigarette smoking and daily alcohol consumption and a 2-month history of progressive dysphagia and dysarthria secondary to an enlarging tongue mass.
  • Direct laryngoscopy revealed a bulky, exophytic mass involving the base of tongue.
  • The diagnosis of sclerosing rhabdomyosarcoma was based on microscopic appearance and patterns of gene expression, including the expression of desmin and myogenin.
  • With the inclusion of the oropharyngeal tumor in the present report, three of the five confirmed cases have occurred in the head and neck.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Sclerosis

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  • (PMID = 15630365.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Fournier HD, Hue AS, Laccourreye L: [Extensive lower clivus chordomas. Removal using the unilateral transmandibular approach]. Neurochirurgie; 2008 Apr;54(2):63-71
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  • BACKGROUND AND PURPOSE: Clival chordomas are rare skull-base tumors with local malignant behavior.
  • If the tumor remains extradural for a while, it finally progresses through the dura backwards to reach and displace the brain stem and upper cervical cord.
  • Tracheostomy is needed because of a transient tongue oedema.
  • RESULTS: The unilateral transmandibular approach enabled to anatomical and physiological nasal preservation, large operative field facilitating dural closure and tumor removal, with acceptable cosmetic results and sequellae considering the natural course and prognosis of the tumor.
  • [MeSH-major] Chordoma / surgery. Mandible / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery

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  • (PMID = 18359050.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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89. Alkan S, Coskun BU, Ugur S, Başak T, Dadas B: Basaloid squamous cell carcinoma of the larynx. Auris Nasus Larynx; 2006 Mar;33(1):71-4
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  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor with distinct morphological and biological features that differentiate it from the common form of squamous cell carcinoma (SCC) in the head and neck region.
  • It is mostly seen in the supraglottic larynx, hypopharynx and a base of the tongue.

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  • (PMID = 16188414.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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90. Jia SS, Xiang C, Liu WS, He HJ: [Supraglottic horizontal partial laryngectomies in 163 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Oct;41(10):763-6
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  • The surgical techniques were improved: The hyoid was removed conventionally; The outer perichondrium of thyroid cartilage was turned into the laryngeal cavity and sutured with the mucosa of laryngeal ventricle and the base of tongue was sutured to the reserved thyroid cartilage.

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  • (PMID = 17190425.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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91. Chao KS, Bhide S, Chen H, Asper J, Bush S, Franklin G, Kavadi V, Liengswangwong V, Gordon W, Raben A, Strasser J, Koprowski C, Frank S, Chronowski G, Ahamad A, Malyapa R, Zhang L, Dong L: Reduce in variation and improve efficiency of target volume delineation by a computer-assisted system using a deformable image registration approach. Int J Radiat Oncol Biol Phys; 2007 Aug 1;68(5):1512-21
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  • MATERIALS AND METHODS: We developed a deformable image registration method for mapping contours from a template case to a patient case with a similar tumor manifestation but different body configuration.
  • Eight radiation oncologists with varying levels of clinical experience in HN IMRT performed target delineation on two HN cases, one with base-of-tongue (BOT) cancer and another with nasopharyngeal cancer (NPC), by first contouring from scratch and then by modifying the contours deformed by the CAT system.
  • [MeSH-major] Medical Oncology / standards. Nasopharyngeal Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted. Tongue Neoplasms / radiotherapy
  • [MeSH-minor] Efficiency. Humans. Tumor Burden

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  • (PMID = 17674982.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Miller FR, Hussey D, Beeram M, Eng T, McGuff HS, Otto RA: Positron emission tomography in the management of unknown primary head and neck carcinoma. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):626-9
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  • PATIENTS: Twenty-six patients with an open excisional biopsy or a fine-needle aspiration biopsy finding that confirmed squamous cell carcinoma of the cervical lymph nodes and no visible primary tumor (as determined by results of a comprehensive physical examination and computed tomography and/or magnetic resonance imaging) underwent PET.
  • MAIN OUTCOME MEASURES: Sensitivity, specificity, and positive and negative predictive values of PET to detect an occult primary tumor.
  • Four occult primary tumors (2 at the base of the tongue and 2 in the tonsil) were detected during routine panendoscopy with negative PET findings.
  • CONCLUSIONS: Positron emission tomography can be a valuable tool to identify a subset of patients with an occult primary tumor in the head and neck region.
  • Early identification of the primary tumor may allow for more accurate tumor staging and targeted radiotherapy to minimize adverse effects and complications.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity. Tongue Neoplasms / radionuclide imaging. Tonsillar Neoplasms / radionuclide imaging

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  • (PMID = 16027287.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Tucker A, Miyake H, Tsuji M, Ukita T, Nishihara K, Ohmura T: Intradural microsurgery and extradural gamma knife surgery for hypoglossal schwannoma: case report and review of the literature. Minim Invasive Neurosurg; 2007 Dec;50(6):374-8
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  • Her neurological exam was significant for nystagmus and left tongue deviation with marked atrophy.
  • A left lateral suboccipital craniotomy was performed for subtotal microsurgical resection of the intradural posterior fossa mass.
  • A schwannoma was diagnosed after resection and gamma knife surgery (GKS) was performed three months later for the extradural residual tumor without further deficits.
  • [MeSH-minor] Adult. Female. Headache / etiology. Humans. Hypoglossal Nerve / pathology. Hypoglossal Nerve / surgery. Magnetic Resonance Imaging. Medulla Oblongata / anatomy & histology. Medulla Oblongata / radiography. Muscular Atrophy / etiology. Muscular Atrophy / pathology. Muscular Atrophy / physiopathology. Nausea / etiology. Occipital Bone / pathology. Occipital Bone / radiography. Occipital Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Skull Base Neoplasms / pathology. Skull Base Neoplasms / radiography. Skull Base Neoplasms / surgery. Tomography, X-Ray Computed. Tongue / innervation. Tongue / pathology. Tongue / physiopathology. Treatment Outcome. Vertigo / etiology

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  • (PMID = 18210363.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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94. Borggreven PA, Verdonck-de Leeuw I, Rinkel RN, Langendijk JA, Roos JC, David EF, de Bree R, Leemans CR: Swallowing after major surgery of the oral cavity or oropharynx: a prospective and longitudinal assessment of patients treated by microvascular soft tissue reconstruction. Head Neck; 2007 Jul;29(7):638-47
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  • Patient, tumor, and treatment factors were assessed.
  • Comorbid condition, larger tumors (T3-T4 vs T2), and resections of the base of tongue and soft palate combined (vs defects of other dynamic structures) were associated with most profound swallowing problems (p < .05).
  • [MeSH-minor] Adult. Aged. Comorbidity. Female. Fluoroscopy. Humans. Longitudinal Studies. Male. Middle Aged. Palate, Soft / surgery. Prospective Studies. Radiotherapy, Adjuvant. Tongue / surgery. Video Recording

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  • (PMID = 17274054.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Donta TS, Smoker WR: Head and neck cancer: carcinoma of unknown primary. Top Magn Reson Imaging; 2007 Aug;18(4):281-92
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  • Squamous cell carcinoma accounts for 70% to 90% of these lesions, most commonly from sites in the upper aerodigestive tract, including tonsils, base of tongue, nasopharynx, and piriform sinus.
  • The location of a metastatic lymph node may give an indication of the primary tumor site, and knowledge of lymph node drainage patterns is important for anyone evaluating these patients.
  • Magnetic resonance and CT are both used for evaluation for extracapsular nodal disease, perineural tumor spread, osseous skull base or perivertebral space involvement, and vascular invasion, findings that seriously impact treatment and prognosis.
  • Positron emission tomography/CT also plays a significant role in detecting primary tumor sites and identifying distant metastatic disease.
  • [MeSH-major] Carcinoma / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 17893593.001).
  • [ISSN] 0899-3459
  • [Journal-full-title] Topics in magnetic resonance imaging : TMRI
  • [ISO-abbreviation] Top Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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96. Hu YH, Li J: [Clear cell carcinoma of salivary gland: a clinicopathologic study of 10 cases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):54-7
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  • RESULTS: Seven tumors were from palate, one was from base of tongue, one in retromolar region, and one in floor of mouth.
  • Microscopically, the tumors were predominantly composed of trabeculae, cords, nests, solid sheets of clear cells and a few eosinophilic cells, and the two kinds of tumor cells were surrounded by hyalinized stroma.
  • CONCLUSIONS: CCC is a distinctive low grade malignant salivary gland neoplasm, arising mainly in the minor salivary glands, and it may originate from intercalated-duct reserve cells.

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  • (PMID = 15774154.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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97. Sato K, Shimizu S, Oka H, Nakahara K, Utsuki S, Fujii K: Usefulness of transcervical approach for surgical treatment of hypoglossal schwannoma with paraspinal extension: case report. Surg Neurol; 2006 Apr;65(4):397-401, discussion 401
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  • The findings were of a tumor lying in the left hypoglossal canal and paraspinal region and were consistent with hypoglossal schwannoma.
  • Subtotal intracapsular removal of the tumor was performed via transcervical approach.
  • CONCLUSION: The transcervical approach and intracapsular removal of the tumor under electrophysiological monitoring provided for successful minimally invasive surgery in this case of hypoglossal schwannoma.
  • [MeSH-minor] Cervical Vertebrae / anatomy & histology. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Decompression, Surgical / methods. Electric Stimulation. Electromyography. Fasciculation / etiology. Fasciculation / pathology. Fasciculation / physiopathology. Female. Humans. Middle Aged. Monitoring, Physiologic. Neoplasm Recurrence, Local / prevention & control. Skull Base / pathology. Skull Base / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / physiopathology. Skull Base Neoplasms / surgery. Tongue / innervation. Tongue / physiopathology. Treatment Outcome

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  • (PMID = 16531208.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Mukhija V, Gupta S, Jacobson AS, Eloy JA, Genden EM: Selective neck dissection following adjuvant therapy for advanced head and neck cancer. Head Neck; 2009 Feb;31(2):183-8
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  • The primary sites included base of tongue (n = 15), hypopharynx (n = 12), tonsil (n = 16), larynx (n = 11), and unknown primary (n = 4).
  • Pathologically, 22.4% (13/58) of the patients had viable tumor cells identified in the neck dissection specimen.
  • Of patients who died from distant disease, 11% had pathological evidence of residual tumor cells identified in the neck dissection specimen.
  • Of patients who died from local or regional disease, 50% had pathological evidence of residual tumor cells identified in the neck dissection specimen.


99. Aubry K, Shao Z, Monteil J, Paraf F, Bessède JP, Rigaud M: FDG-PET/CT of head and neck squamous cell carcinoma in a rat model. Mol Imaging Biol; 2009 Mar-Apr;11(2):88-93
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  • RESULTS: All rats had head and neck tumor at various locations at 34 weeks.
  • FDG-PET/CT confirmed the presence of those tumors and detected ones located on the base of tongue for three of them.
  • Tumor extensions were characterized and tumor metabolic volumes were measured.
  • It is useful to follow tumor progression and evaluate therapeutics efficacy.

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  • (PMID = 19034583.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18; 56-57-5 / 4-Nitroquinoline-1-oxide
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100. Watanabe A, Taniguchi M: [A case of oropharyngeal cancer with multiple bone metastases from prostate cancer that responded to docetaxel, ifosfamide and cisplatin combination therapy]. Gan To Kagaku Ryoho; 2005 Jan;32(1):65-7
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  • After chemotherapy, computed tomography revealed no residual tumor at the oropharyngeal region, but a small ulcer was seen at the base of the tongue by laryngopharyngoscopy.






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